ferredoxin nadp reductase

Summary

Summary: An enzyme that catalyzes the oxidation and reduction of FERREDOXIN or ADRENODOXIN in the presence of NADP. EC 1.18.1.2 was formerly listed as EC 1.6.7.1 and EC 1.6.99.4.

Top Publications

  1. ncbi Predictive reconstruction of the mitochondrial iron-sulfur cluster assembly metabolism: I. The role of the protein pair ferredoxin-ferredoxin reductase (Yah1-Arh1)
    Rui Alves
    Departament de Ciencies Mediques Basiques, Universidad de Lleida, Lleida, Spain
    Proteins 56:354-66. 2004
  2. ncbi The role of chloroplastic NAD(P)H dehydrogenase in photoprotection
    T Endo
    Division of Integrated Life Sciences, Graduate School of Biostudies, Kyoto University, Japan
    FEBS Lett 457:5-8. 1999
  3. ncbi Structural and functional characterization of ferredoxin-NADP+-oxidoreductase using knock-out mutants of Arabidopsis
    Minna Lintala
    Laboratory Plant Physiology and Molecular Biology, Department of Biology, University of Turku, FIN 20014 Turku, Finland
    Plant J 49:1041-52. 2007
  4. ncbi The methionine synthase reductase (MTRR) A66G polymorphism is a novel genetic determinant of plasma homocysteine concentrations
    D J Gaughan
    Department of Pharmacology and Center for Pharmacogenetics, University of Pennsylvania School of Medicine, 153 Johnson Pavilion, 3620 Hamilton Walk, Philadelphia, PA 19104 6084, USA
    Atherosclerosis 157:451-6. 2001
  5. pmc X-ray crystallographic and solution state nuclear magnetic resonance spectroscopic investigations of NADP+ binding to ferredoxin NADP reductase from Pseudomonas aeruginosa
    An Wang
    Ralph N Adams Institute for Bioanalytical Chemistry and Department of Chemistry, University of Kansas, Multidisciplinary Research Building, 2030 Becker Drive, Room 220 E, Lawrence, Kansas 66047, USA
    Biochemistry 47:8080-93. 2008
  6. ncbi Involvement of the pyrophosphate and the 2'-phosphate binding regions of ferredoxin-NADP+ reductase in coenzyme specificity
    Jesús Tejero
    Departamento de Bioquimica y Biologia Molecular y Celular, Facultad de Ciencias, Universidad de Zaragoza, 50009 Zaragoza, Madrid, Spain
    J Biol Chem 278:49203-14. 2003
  7. ncbi Comparative analysis of leaf-type ferredoxin-NADP oxidoreductase isoforms in Arabidopsis thaliana
    Minna Lintala
    Laboratory of Plant Physiology and Molecular Biology, Department of Biology, University of Turku, Turku, Finland
    Plant J 57:1103-15. 2009
  8. ncbi Association study of four polymorphisms in three folate-related enzyme genes with non-obstructive male infertility
    Han Chul Lee
    Functional Genomics Lab, CHA Research Institute, Bundang Campus, College of Medicine, Pochon CHA University, Kyunggi Do, Republic of Korea
    Hum Reprod 21:3162-70. 2006
  9. ncbi Expression of multiple forms of ferredoxin NADP+ oxidoreductase in wheat leaves
    J O Gummadova
    Faculty of Life Sciences, The University of Manchester, 3 614 Stopford Building, Oxford Road, Manchester M13 9PT, UK
    J Exp Bot 58:3971-85. 2007
  10. ncbi cblE type of homocystinuria due to methionine synthase reductase deficiency: functional correction by minigene expression
    Petra Zavadakova
    Institute of Inherited Metabolic Diseases, 1st Faculty of Medicine, Charles University, Prague, Czech Republic
    Hum Mutat 25:239-47. 2005

Research Grants

  1. 7 FE FDI AS A MODEL FE-S AND REGULATORY PROTEIN
    Thomas Poulos; Fiscal Year: 2002
  2. Thermodynamic Properties of NADH:Nitrate Reductase
    Michael Barber; Fiscal Year: 2005
  3. FLAVIN-PROTEIN INTERACTIONS IN FLAVOENZYME CATALYSIS
    Gordon Tollin; Fiscal Year: 2001
  4. IODINE METABOLISM OF THE THYROID GLAND
    ISADORE ROSENBERG; Fiscal Year: 1990
  5. Epidemiologic Study of Placental Abruption
    Cande Ananth; Fiscal Year: 2006
  6. ANDROGEN PRODUCTION IN ADRENARCHE AND PCOS
    WALTER MILLER; Fiscal Year: 2006
  7. Structure/Function Studies on Flavoproteins
    Irina Sevrioukova; Fiscal Year: 2007
  8. Gene-Nutrient Interactions and Breast Cancer
    SUSAN STECK; Fiscal Year: 2007
  9. Role of CRH in skin physiology and pathology
    Andrzej Slominski; Fiscal Year: 2004

Detail Information

Publications211 found, 100 shown here

  1. ncbi Predictive reconstruction of the mitochondrial iron-sulfur cluster assembly metabolism: I. The role of the protein pair ferredoxin-ferredoxin reductase (Yah1-Arh1)
    Rui Alves
    Departament de Ciencies Mediques Basiques, Universidad de Lleida, Lleida, Spain
    Proteins 56:354-66. 2004
    ..Only when this mode of action of either of the two proteins in FeSC synthesis is considered can previously reported results be reproduced...
  2. ncbi The role of chloroplastic NAD(P)H dehydrogenase in photoprotection
    T Endo
    Division of Integrated Life Sciences, Graduate School of Biostudies, Kyoto University, Japan
    FEBS Lett 457:5-8. 1999
    ..The mechanism of the phenomena is discussed with respect to the potential role of NDH in photosynthesis...
  3. ncbi Structural and functional characterization of ferredoxin-NADP+-oxidoreductase using knock-out mutants of Arabidopsis
    Minna Lintala
    Laboratory Plant Physiology and Molecular Biology, Department of Biology, University of Turku, FIN 20014 Turku, Finland
    Plant J 49:1041-52. 2007
    ..Dimer formation, in turn, might regulate the distribution of electrons between the cyclic and linear electron transfer pathways according to environmental cues...
  4. ncbi The methionine synthase reductase (MTRR) A66G polymorphism is a novel genetic determinant of plasma homocysteine concentrations
    D J Gaughan
    Department of Pharmacology and Center for Pharmacogenetics, University of Pennsylvania School of Medicine, 153 Johnson Pavilion, 3620 Hamilton Walk, Philadelphia, PA 19104 6084, USA
    Atherosclerosis 157:451-6. 2001
    ..This study provides the first evidence that the MTRR A66G polymorphism significantly influences the circulating tHcy concentration...
  5. pmc X-ray crystallographic and solution state nuclear magnetic resonance spectroscopic investigations of NADP+ binding to ferredoxin NADP reductase from Pseudomonas aeruginosa
    An Wang
    Ralph N Adams Institute for Bioanalytical Chemistry and Department of Chemistry, University of Kansas, Multidisciplinary Research Building, 2030 Becker Drive, Room 220 E, Lawrence, Kansas 66047, USA
    Biochemistry 47:8080-93. 2008
    ..These findings are discussed in the context of a possible stepwise electron-proton-electron transfer of hydride in the oxidation of NADPH by FPR enzymes...
  6. ncbi Involvement of the pyrophosphate and the 2'-phosphate binding regions of ferredoxin-NADP+ reductase in coenzyme specificity
    Jesús Tejero
    Departamento de Bioquimica y Biologia Molecular y Celular, Facultad de Ciencias, Universidad de Zaragoza, 50009 Zaragoza, Madrid, Spain
    J Biol Chem 278:49203-14. 2003
    ..Such observations also suggest that other regions of the protein, yet to be identified, might also be involved in this process...
  7. ncbi Comparative analysis of leaf-type ferredoxin-NADP oxidoreductase isoforms in Arabidopsis thaliana
    Minna Lintala
    Laboratory of Plant Physiology and Molecular Biology, Department of Biology, University of Turku, Turku, Finland
    Plant J 57:1103-15. 2009
    ..These results emphasize a critical role for FNR2 in the redistribution of electrons to various reducing pathways, upon conditions that modify the photosynthetic capacity of the plant...
  8. ncbi Association study of four polymorphisms in three folate-related enzyme genes with non-obstructive male infertility
    Han Chul Lee
    Functional Genomics Lab, CHA Research Institute, Bundang Campus, College of Medicine, Pochon CHA University, Kyunggi Do, Republic of Korea
    Hum Reprod 21:3162-70. 2006
    ..We evaluated whether polymorphisms of these three enzymes are associated with non-obstructive male infertility...
  9. ncbi Expression of multiple forms of ferredoxin NADP+ oxidoreductase in wheat leaves
    J O Gummadova
    Faculty of Life Sciences, The University of Manchester, 3 614 Stopford Building, Oxford Road, Manchester M13 9PT, UK
    J Exp Bot 58:3971-85. 2007
    ....
  10. ncbi cblE type of homocystinuria due to methionine synthase reductase deficiency: functional correction by minigene expression
    Petra Zavadakova
    Institute of Inherited Metabolic Diseases, 1st Faculty of Medicine, Charles University, Prague, Czech Republic
    Hum Mutat 25:239-47. 2005
    ..The identification of mutations in the MTRR gene, together with restoration of methionine synthesis following MTRR minigene expression in cblE cells confirms that this disease is caused by defects in the MTRR gene...
  11. ncbi Molecular basis for methionine synthase reductase deficiency in patients belonging to the cblE complementation group of disorders in folate/cobalamin metabolism
    A Wilson
    MRC Group in Medical Genetics, Montreal Children s Hospital, Canada
    Hum Mol Genet 8:2009-16. 1999
    ..These data demonstrate a unique requirement for MSR in the reductive activation of MS...
  12. ncbi Ferredoxin-NADP+ reductase from Plasmodium falciparum undergoes NADP+-dependent dimerization and inactivation: functional and crystallographic analysis
    Mario Milani
    CNR INFM, Department of Biomolecular Sciences and Biotechnology, University of Milano, Via Celoria 26, 20133 Milano, Italy
    J Mol Biol 367:501-13. 2007
    ..falciparum ferredoxin-NADP(+) reductase as particularly suited for the rational development of antimalarial compounds...
  13. pmc Cloning and mapping of a cDNA for methionine synthase reductase, a flavoprotein defective in patients with homocystinuria
    D Leclerc
    Medical Research Council Group in Medical Genetics, The Montreal Children s Hospital, McGill University Health Centre, Montreal, PQ, Canada H3Z 2Z3
    Proc Natl Acad Sci U S A 95:3059-64. 1998
    ..The cloning of the cDNA will permit the diagnostic characterization of cblE patients and investigation of the potential role of polymorphisms of this enzyme as a risk factor in hyperhomocysteinemia-linked vascular disease...
  14. ncbi Analysis of methionine synthase reductase polymorphisms for neural tube defects risk association
    Valerie B O'Leary
    Department of Biochemistry, Trinity College Dublin, Dublin, Ireland
    Mol Genet Metab 85:220-7. 2005
    ..The frequencies of I22M and K350R differed significantly between the two groups (p = 0.0005 and p = 0.0001, respectively). Our findings do not support an important role for these MTRR variants in NTDs...
  15. ncbi Structure of the electron transfer complex between ferredoxin and ferredoxin-NADP(+) reductase
    G Kurisu
    Research Center for Structural Biology, Institute for Protein Research, Osaka University, Suita, Osaka 565 0871, Japan
    Nat Struct Biol 8:117-21. 2001
    ..We propose that this type of molecular communication not only determines the optimal orientation of the two proteins for electron transfer, but also contributes to the modulation of the enzymatic properties of FNR...
  16. pmc Three maize leaf ferredoxin:NADPH oxidoreductases vary in subchloroplast location, expression, and interaction with ferredoxin
    Satoshi Okutani
    Institute for Protein Research, Osaka University, Suita, Osaka 565 0871, Japan
    Plant Physiol 139:1451-9. 2005
    ..These results are discussed in terms of the functional differentiation of maize LFNR isoenzymes...
  17. ncbi Functional plasticity and catalytic efficiency in plant and bacterial ferredoxin-NADP(H) reductases
    Eduardo A Ceccarelli
    Facultad de Ciencias Bioquimicas y Farmaceuticas, Molecular Biology Division, Instituto de Biologia Molecular y Celular de Rosario IBR, Universidad Nacional de Rosario, Suipacha 531, S2002LRK Rosario, Argentina
    Biochim Biophys Acta 1698:155-65. 2004
    ..Sequence alignments supported this classification, providing a criterion to predict the structural and biochemical properties of newly identified members of the family...
  18. ncbi Reduction of the pea ferredoxin-NADP(H) reductase catalytic efficiency by the structuring of a carboxyl-terminal artificial metal binding site
    Daniela L Catalano-Dupuy
    Molecular Biology Division, Instituto de Biologia Molecular y Celular de Rosario, Facultad de Ciencias Bioquimicas y Farmaceuticas, Universidad Nacional de Rosario, Suipacha 531, S2002LRK Rosario, Argentina
    Biochemistry 45:13899-909. 2006
    ..Our results provide experimental evidence which indicates that mobility of the carboxyl-terminal backbone region of the FNR, mainly Tyr308, is essential for obtaining an FNR enzyme with high catalytic efficiency...
  19. ncbi Folic acid
    J G Donnelly
    Department of Pathology, the Ottawa Hospital and the University of Ottawa, Ontario, Canada
    Crit Rev Clin Lab Sci 38:183-223. 2001
    ..Recently, common polymorphisms have been discovered in several genes associated with folate pathways that may play a role in diseases associated with folate deficiency, particularly mild folate deficiency...
  20. ncbi Open questions in ferredoxin-NADP+ reductase catalytic mechanism
    Nestor Carrillo
    Molecular Biology Division, Instituto de Biologia Molecular y Celular de Rosario IBR, Facultad de Ciencias Bioquimicas y Farmaceuticas, Universidad Nacional de Rosario, Argentina
    Eur J Biochem 270:1900-15. 2003
    ..Flavoenzymes with FNR activity catalyse a number of reactions with potential importance for biotechnological processes, so that modification of their catalytic competence is relevant on both scientific and technical grounds...
  21. ncbi MTRR and MTHFR polymorphism: link to Down syndrome?
    Valerie B O'Leary
    Department of Biochemistry, Trinity College, Dublin, Ireland
    Am J Med Genet 107:151-5. 2002
    ..Women who have both the MTRR and MTHFR variant genotypes are also at increased risk of producing offspring with Down syndrome...
  22. ncbi Mechanism of coenzyme recognition and binding revealed by crystal structure analysis of ferredoxin-NADP+ reductase complexed with NADP+
    Juan A Hermoso
    Grupo de Cristalografia Macromolecular y Biologia Estructural, Instituto Quimica Fisica Rocasolano, C S I C, Serrano 119, 28006 Madrid, Spain
    J Mol Biol 319:1133-42. 2002
    ..Finally, structural comparison with the members of the broad FNR structural family also provides an explanation for the high specificity exhibited by FNR for NADP+/H versus NAD+/H...
  23. ncbi Tethering of ferredoxin:NADP+ oxidoreductase to thylakoid membranes is mediated by novel chloroplast protein TROL
    Snjezana Jurić
    Department of Molecular Biology, Ruder Boskovic Institute, Bijenicka cesta 54, HR 10000 Zagreb, Croatia
    Plant J 60:783-94. 2009
    ..Thus, TROL might represent a missing thylakoid membrane docking site for a complex between FNR, ferredoxin and NADP(+). Such association might be necessary for maintaining photosynthetic redox poise and enhancement of the NPQ...
  24. ncbi X-ray structure of the ferredoxin:NADP+ reductase from the cyanobacterium Anabaena PCC 7119 at 1.8 A resolution, and crystallographic studies of NADP+ binding at 2.25 A resolution
    L Serre
    IBS LCCP, Grenoble, France
    J Mol Biol 263:20-39. 1996
    ....
  25. ncbi Identification of the N- and C-terminal substrate binding segments of ferredoxin-NADP+ reductase by NMR
    Masahiro Maeda
    Institute for Protein Research, Osaka University, Yamadaoka 3 2, Suita, Osaka 565 0871, Japan
    Biochemistry 44:10644-53. 2005
    ..Since the ends of the polypeptide chain act as flexible regions of proteins, they may contribute to the search of a larger space for a binding partner and to the opening of active sites...
  26. ncbi Partially folded structure of flavin adenine dinucleotide-depleted ferredoxin-NADP+ reductase with residual NADP+ binding domain
    Masahiro Maeda
    Institute for Protein Research, Osaka University, 3 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Biol Chem 277:17101-7. 2002
    ..These results suggested that FAD-depleted FNR assumes a partially folded structure with a residual NADP(+) binding domain but a disordered FAD binding domain...
  27. ncbi The ferredoxin-NADP(H) reductase from Rhodobacter capsulatus: molecular structure and catalytic mechanism
    Isabel Nogues
    Departamento de Bioquimica y Biologia Molecular y Celular, Facultad de Ciencias, and Institute of Biocomputation and Physics of Complex Systems BIFI, Universidad de Zaragoza, Zaragoza, Spain
    Biochemistry 44:11730-40. 2005
    ..The results indicate that one-electron reduction of oxidized flavodoxin limits the enzyme activity in vitro, and support the notion that flavodoxin oscillates between the semiquinone and fully reduced states when FPR operates in vivo...
  28. ncbi The three-dimensional structure of flavodoxin reductase from Escherichia coli at 1.7 A resolution
    M Ingelman
    Department of Molecular Biology, Swedish University of Agricultural Sciences, Uppsala Biomedical Center
    J Mol Biol 268:147-57. 1997
    ..There is a pronounced cleft close to the isoalloxazine that appears to be well suited for binding of flavodoxin/ferredoxin. Two extra short strands of the NADP-binding domain probably act as an anchor point for the binding of flavodoxin...
  29. ncbi Biochemical and crystallographic characterization of ferredoxin-NADP(+) reductase from nonphotosynthetic tissues
    A Aliverti
    Dipartimento di Fisiologia e Biochimica Generali, , Via Celoria 26, 20133 Milano, Italy
    Biochemistry 40:14501-8. 2001
    ....
  30. ncbi Homologous protein import machineries in chloroplasts and cyanelles
    Jürgen M Steiner
    Max F Perutz Laboratories, University Departments at the Vienna Biocenter, Department of Biochemistry and Ludwig Boltzmann Research Unit for Biochemistry, Dr Bohrgasse 9, 1030 Vienna, Austria
    Plant J 44:646-52. 2005
    ..In chloroplasts, multiple receptors with overlapping and less stringent specificities have evolved, explaining the efficient heterologous import of native precursors from C. paradoxa...
  31. ncbi Stripping down the mitochondrial cholesterol hydroxylase system, a kinetics study
    Burkhard Schiffler
    Naturwissenschaftlich Technische Fakultät III, FR 8 8 Biochemie, Universitat des Saarlandes, P O Box 151150, D 66041 Saarbrucken, Germany
    J Biol Chem 279:34269-76. 2004
    ....
  32. ncbi Molecular mechanism of the redox-dependent interaction between NADH-dependent ferredoxin reductase and Rieske-type [2Fe-2S] ferredoxin
    Miki Senda
    Japan Biological Information Research Center, Japan Biological Informatics Consortium, 2 42 Aomi, Koto ku, Tokyo 135 0064, Japan
    J Mol Biol 373:382-400. 2007
    ..The interplay of electron transfer and induced conformational changes seems to be critical to the sequential electron-transfer reaction from NADH to BphA3...
  33. ncbi One-carbon metabolism-related gene polymorphisms and risk of breast cancer
    Takeshi Suzuki
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Carcinogenesis 29:356-62. 2008
    ..008). Our findings indicated that the MTHFR and MTRR polymorphisms were associated with individual susceptibility to breast cancer among postmenopausal women...
  34. ncbi Differences in the efficiency of reductive activation of methionine synthase and exogenous electron acceptors between the common polymorphic variants of human methionine synthase reductase
    Horatiu Olteanu
    Biochemistry Department, University of Nebraska, Lincoln, Nebraska 68588 0664, USA
    Biochemistry 41:13378-85. 2002
    ..These results reveal differences in the interactions between the natural and artificial electron acceptors and MSR variants in vitro, which are predicted to result in less efficient reductive repair of methionine synthase in vivo...
  35. ncbi Probing the role of glutamic acid 139 of Anabaena ferredoxin-NADP+ reductase in the interaction with substrates
    Merche Faro
    Departamento de Bioquimica y Biologia Molecular y Celular, Facultad de Ciencias, Universidad de Zaragoza, Spain
    Eur J Biochem 269:4938-47. 2002
    ..Our observations further confirm the contribution of both attractive and repulsive interactions in achieving the optimal orientation for efficient ET between FNR and its protein carriers...
  36. ncbi RbrA, a cyanobacterial rubrerythrin, functions as a FNR-dependent peroxidase in heterocysts in protection of nitrogenase from damage by hydrogen peroxide in Anabaena sp. PCC 7120
    Weixing Zhao
    State Key Laboratory of Protein and Plant Genetic Engineering, College of Life Sciences, Peking University, Beijing, 100871, China
    Mol Microbiol 66:1219-30. 2007
    ..Our results demonstrate that RbrA is a critical enzyme for H(2)O(2) decomposition and provide evidence that nitrogenase autoprotection is important in heterocysts...
  37. ncbi Are genetic variants of the methyl group metabolism enzymes risk factors predisposing to obesity?
    I Terruzzi
    Division of Internal Medicine, Section of Nutrition Metabolism, San Raffaele Scientific Institute, 20132 Milano, Italy
    J Endocrinol Invest 30:747-53. 2007
    ....
  38. ncbi Genetic determinants of methotrexate toxicity in rheumatoid arthritis patients: a study of polymorphisms affecting methotrexate transport and folate metabolism
    Petra Bohanec Grabar
    Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia
    Eur J Clin Pharmacol 64:1057-68. 2008
    ....
  39. ncbi Association between polymorphisms of folate-metabolizing enzymes and risk of prostate cancer
    C Marchal
    Urology Department, Hospital Clinico Universitario, Virgen de la Victoria, Campus de Teatinos s n, Malaga 29010, Spain
    Eur J Surg Oncol 34:805-10. 2008
    ....
  40. ncbi Effects of folic acid fortification and multivitamin therapy on homocysteine and vitamin B(12) status in cardiac transplant recipients
    Santiago G Miriuka
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    J Heart Lung Transplant 23:405-12. 2004
    ..In 1998, food in Canada was fortified nationwide with folic acid. We assessed the impact of routine folate fortification on homocysteine concentrations in our cardiac transplant population...
  41. ncbi Mycobacterium tuberculosis FprA, a novel bacterial NADPH-ferredoxin reductase
    Federico Fischer
    Dipartimento di Fisiologia e Biochimica Generali, Universita degli Studi di Milano, Milano, Italy
    Eur J Biochem 269:3005-13. 2002
    ..A Km value of 30 nm and a specificity constant of 110 microM(-1) x s(-1) (10 times greater than that for the 2Fe ferredoxin) were determined for this ferredoxin. The systematic name for FprA is therefore NADPH-ferredoxin oxidoreductase...
  42. ncbi Polymorphisms in genes involved in folate metabolism and colorectal neoplasia: a HuGE review
    Linda Sharp
    Epidemiology Group, Department of Medicine and Therapeutics, University of Aberdeen, Scotland, UK
    Am J Epidemiol 159:423-43. 2004
    ..Overall, the roles of folate-pathway genes, folate, and related dietary factors in colorectal neoplasia are complex. Research priorities are suggested...
  43. ncbi Optical biosensor and scanning probe microscopy studies of cytochrome P450 interactions with redox partners and phospholipid layers
    Alexander I Archakov
    Institute of Biomedical Chemistry, Russian Academy of Medical Sciences, Moscow 119992, Russia
    Methods Enzymol 357:94-103. 2002
  44. ncbi Methionine synthase (MTR) 2756 (A --> G) polymorphism, double heterozygosity methionine synthase 2756 AG/methionine synthase reductase (MTRR) 66 AG, and elevated homocysteinemia are three risk factors for having a child with Down syndrome
    Paolo Bosco
    IRCCS, Oasi Maria S S Institute for Research on Mental Retardation and Brain Aging, Troina EN, Italy
    Am J Med Genet A 121:219-24. 2003
    ..0 (95% CI: 1.1-24.1), after adjustment for t-Hcys. In conclusion, our results provide evidences that homocysteine and MTR genetic polymorphism are two potent risk factors for mothers to have a DS child in Sicily...
  45. ncbi Polymorphisms in genes related to folate and cobalamin metabolism and the associations with complex birth defects
    R Brouns
    Department of Clinical Chemistry, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    Prenat Diagn 28:485-93. 2008
    ..To investigate the associations between biomarkers and genetic variants involved in homocysteine metabolism and the risk of complex birth defects...
  46. ncbi Role of the C-terminal tyrosine of ferredoxin-nicotinamide adenine dinucleotide phosphate reductase in the electron transfer processes with its protein partners ferredoxin and flavodoxin
    Isabel Nogues
    Departamento de Bioquímica y Biología Molecular y Celular and Biocomputation and Complex Systems Physics Institute, Facultad de Ciencias, Universidad de Zaragoza, 50009 Zaragoza, Spain
    Biochemistry 43:6127-37. 2004
    ....
  47. ncbi One-carbon metabolism-related gene polymorphisms and risk of head and neck squamous cell carcinoma: case-control study
    Takeshi Suzuki
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Cancer Sci 98:1439-46. 2007
    ..04), MTR A2756G (P = 0.04) and MTRR A66G (P = 0.03) polymorphisms. The results suggest that there may be interactions between one-carbon metabolism-related polymorphisms and alcohol drinking for HNSCC risk...
  48. ncbi Nutritional and genetic determinants of vitamin B and homocysteine metabolisms in neural tube defects: a multicenter case-control study
    Mirande Candito
    INSERM U 145, Department of Biochemistry, CHU Nice Hôpital Pasteur, Nice, France
    Am J Med Genet A 146:1128-33. 2008
    ..Genetic polymorphisms played only a small role. Until folic acid fortification becomes mandatory, all women of reproductive age should consume folic acid in a multivitamin that also contains B12 and B6...
  49. pmc Kinetic, spectroscopic and thermodynamic characterization of the Mycobacterium tuberculosis adrenodoxin reductase homologue FprA
    Kirsty J McLean
    Department of Biochemistry, University of Leicester, The Adrian Building, University Road, UK
    Biochem J 372:317-27. 2003
    ..J. Biochem. 269, 3005-3013]...
  50. ncbi Role of hydrophobic interactions in the flavodoxin mediated electron transfer from photosystem I to ferredoxin-NADP+ reductase in Anabaena PCC 7119
    Isabel Nogues
    Departamento de Bioquimica y Biologia Molecular y Celular, Facultad de Ciencias, Universidad de Zaragoza, 50009 Zaragoza, Spain
    Biochemistry 42:2036-45. 2003
    ..From these data, significant effects are evident, especially for the I92 position of Fld, both in the association constant for complex formation and in the electron-transfer rate constant in the PSI/Fld system...
  51. ncbi Homocysteine concentrations in adults with trisomy 21: effect of B vitamins and genetic polymorphisms
    Nathalie Fillon-Emery
    Faculte de Medecine, Laboratory of Medical Biochemistry, Vandoeuvre les Nancy, France
    Am J Clin Nutr 80:1551-7. 2004
    ..The effects of supplementation with B vitamins and of common polymorphisms in genes involved in homocysteine metabolism on plasma total homocysteine (tHcy) concentrations in trisomy 21 are unknown...
  52. ncbi Insights into the design of a hybrid system between Anabaena ferredoxin-NADP+ reductase and bovine adrenodoxin
    Merche Faro
    Departamento de Bioquimica y Biologia Molecular y Celular, Facultad de Ciencias, Universidad de Zaragoza, Spain
    Eur J Biochem 270:726-35. 2003
    ....
  53. ncbi Expression and characterization of ferredoxin and flavin adenine dinucleotide binding domains of the reductase component of soluble methane monooxygenase from Methylococcus capsulatus (Bath)
    Jessica L Blazyk
    Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Biochemistry 41:15780-94. 2002
    ....
  54. ncbi Effects of polymorphisms of methionine synthase and methionine synthase reductase on total plasma homocysteine in the NHLBI Family Heart Study
    Paul F Jacques
    Jean Mayer USDA, Human Nutrition Research Center on Aging at Tufts University, 711 Wasington Street, Boston, MA 02111, USA
    Atherosclerosis 166:49-55. 2003
    ..This study provides no evidence that these common MTR and MTRR mutations are associated with alterations in plasma homocysteine...
  55. ncbi Structural and functional diversity of ferredoxin-NADP(+) reductases
    Alessandro Aliverti
    Dipartimento di Scienze Biomolecolari e Biotecnologie, Universita degli Studi di Milano, Via Celoria 26, 20133 Milano, Italy
    Arch Biochem Biophys 474:283-91. 2008
    ..Plant-type FNRs from bacteria and Apicomplexan parasites provide examples of novel ways of FAD- and NADP(H)-binding. The recent characterization of an FNR from Plasmodium falciparum brings these enzymes into the field of drug design...
  56. ncbi Essential hypertension in adolescents: association with insulin resistance and with metabolism of homocysteine and vitamins
    Regina Kahleová
    Institute of Inherited Metabolic Disease, Charles University, 1st Faculty of Medicine, Prague, Czech Republic
    Am J Hypertens 15:857-64. 2002
    ..We examined whether insulin resistance and disturbed homocysteine metabolism are present in young adults at the early stages of essential hypertension...
  57. ncbi An approach based on quantum chemistry calculations and structural analysis of a [2Fe-2S] ferredoxin that reveal a redox-linked switch in the electron-transfer process to the Fd-NADP+ reductase
    Renaud Morales
    Service de Chimie Inorganique et Biologique, UMR 5046, DRFMC CEA Grenoble, 17 rue des Martyrs, 38041 Grenoble, France
    J Am Chem Soc 124:6714-22. 2002
    ..e., Ser or Thr) at location 47. We propose that the Phe65 ring acts as an intermediary carrier receiving the reducing electron prior to its transfer from the reduced Fd to FNR, in view of its central role in the Fd-FNR interaction...
  58. ncbi Genetic polymorphisms predisposing to hyperhomocysteinemia in cardiac transplant patients
    Santiago G Miriuka
    Department of Medicine, Toronto General Hospital and University of Toronto, Toronto, Ontario, Canada
    Transpl Int 18:29-35. 2005
    ..Thus, SNP in Hcy-regulating genes may be important determinants of vitamin metabolism in CTX, raising the question of increased vitamin requirements to minimize increased plasma Hcy in this high-risk group...
  59. ncbi No association between common polymorphisms in genes of folate and homocysteine metabolism and the risk of Down's syndrome among French mothers
    Abalo Chango
    INSERM U 724, Laboratory of Nutritional Genomics, ISAB Agrohealth, 60026 Beauvais, France
    Br J Nutr 94:166-9. 2005
    ..The risk of having a child with trisomy 21 did not appear to be linked to polymorphisms in genes associated with folate and homocysteine metabolism...
  60. ncbi Abnormal folate metabolism in mothers with Down syndrome offspring: review of the literature
    T K A B Eskes
    University Medical Center St Radboud, 6500 HB Nijmegen NL, Netherlands
    Eur J Obstet Gynecol Reprod Biol 124:130-3. 2006
    ..This finding, in addition to the prevention of neural tube defects, strengthens the recommendation to use folic acid around conception...
  61. ncbi New aspects of electron transfer revealed by the crystal structure of a truncated bovine adrenodoxin, Adx(4-108)
    A Muller
    Forschungsgruppe Kristallographie, Max Delbruck Centrum fur Molekulare Medizin, Berlin, Germany
    Structure 6:269-80. 1998
    ..A crystallographic study of Adx is expected to reveal the structural basis for an important electron transfer reaction mediated by a vertebrate [2Fe-2S] ferredoxin...
  62. pmc Crystallization and preliminary X-ray diffraction studies of ferredoxin reductase from Leptospira interrogans
    Alessandro S Nascimento
    Instituto de Fisica de Sao Carlos, Universidade de Sao Paulo, Av Trabalhador Saocarlense 400, Sao Carlos, SP, 13560 970, Brazil
    Acta Crystallogr Sect F Struct Biol Cryst Commun 62:662-4. 2006
    ..The L. interrogans FNR crystals belong to a primitive monoclinic space group and diffract to 2.4 angstroms resolution at a synchrotron source...
  63. ncbi Iron-sulfur cluster cysteine-to-serine mutants of Anabaena -2Fe-2S- ferredoxin exhibit unexpected redox properties and are competent in electron transfer to ferredoxin:NADP+ reductase
    J K Hurley
    Department of Biochemistry, University of Arizona, Tucson, Arizona 85721, USA
    Biochemistry 36:15109-17. 1997
    ....
  64. ncbi Structure-function relationships in Anabaena ferredoxin: correlations between X-ray crystal structures, reduction potentials, and rate constants of electron transfer to ferredoxin:NADP+ reductase for site-specific ferredoxin mutants
    J K Hurley
    Department of Biochemistry, University of Arizona, Tucson, Arizona 85721, USA
    Biochemistry 36:11100-17. 1997
    ..Rather, the kinetic properties are most likely controlled by the specific orientations of the proteins within the transient electron-transfer complex...
  65. ncbi Genetic and nutritional factors contributing to hyperhomocysteinemia in young adults
    Leo A J Kluijtmans
    Department of Pharmacology and Center for Pharmacogenetics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Blood 101:2483-8. 2003
    ..These data underscore the potential benefits that may be gained by improving the dietary status of young adults, and provide support for the implementation of folate/B-vitamin food fortification programs...
  66. ncbi Cloning and characterization of ferredoxin and ferredoxin-NADP+ reductase from human malaria parasite
    Yoko Kimata-Ariga
    Institute for Protein Research, Osaka University, 3 2 Yamadaoka, Suita, Japan
    J Biochem 141:421-8. 2007
    ..falciparum Fd in a reconstituted system of NADPH-dependent cytochrome c reduction. These results indicate that an NADPH-FNR-Fd cascade is operative in the apicoplast of human malaria parasites...
  67. ncbi Reconstitution of an apicoplast-localised electron transfer pathway involved in the isoprenoid biosynthesis of Plasmodium falciparum
    René C Röhrich
    Biochemisches Institut, Justus Liebig Universitat Giessen, Friedrichstrasse 24, 35392 Giessen, Germany
    FEBS Lett 579:6433-8. 2005
    ..LytB and ferredoxin were found to form a stable protein complex. These data suggest that the ferredoxin/ferredoxin-NADP(+) reductase redox system serves as the physiological electron donor for LytB in the apicoplast of P. falciparum...
  68. ncbi Polymorphisms in folate metabolizing genes and risk for spontaneous preterm and small-for-gestational age birth
    Stephanie M Engel
    Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, NY, USA
    Am J Obstet Gynecol 195:1231.e1-11. 2006
    ..Variants in the folate metabolism pathway affect the accumulation of homocysteine are modified by nutrient levels and have been linked to adverse birth outcomes...
  69. ncbi Study of four genes belonging to the folate pathway: transcobalamin 2 is involved in the onset of non-syndromic cleft lip with or without cleft palate
    Marcella Martinelli
    Department of Morphology and Embryology, University of Ferrara, Ferrara, Italy
    Hum Mutat 27:294. 2006
    ....
  70. ncbi Influence of methionine synthase (A2756G) and methionine synthase reductase (A66G) polymorphisms on plasma homocysteine levels and relation to risk of coronary artery disease
    Abdelilah Laraqui
    Ligue nationale de lutte contre les maladies cardiovasculaires, Laboratoire de Biochimie et de Biologie Moleculaire, CHU Avicenne, Rabat, Morocco
    Acta Cardiol 61:51-61. 2006
    ..We also determined the genotype frequencies distribution of the A2756G transition of the B12-dependent methionine synthase (MTR) gene and the A66G mutation of the methionine synthase reductase (MTRR) gene...
  71. ncbi Interaction between mitochondrial CYP27B1 and adrenodoxin: role of arginine 458 of mouse CYP27B1
    Naoko Urushino
    Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    Biochemistry 45:4405-12. 2006
    ..These results suggest that ADX functions as an effector for the oxygen transfer reaction in addition to being an electron donor for CYP27B1...
  72. ncbi Role of Arg100 and Arg264 from Anabaena PCC 7119 ferredoxin-NADP+ reductase for optimal NADP+ binding and electron transfer
    M Martinez-Julvez
    Departamento de Bioquimica y Biologia Molecular y Celular, Facultad de Ciencias, Universidad de Zaragoza, Spain
    Biochemistry 37:17680-91. 1998
    ..However, this mutant showed altered behavior in its interaction and electron transfer with its protein partners, ferredoxin and flavodoxin...
  73. ncbi Role of positively charged residues lys267, lys270, and arg411 of cytochrome p450scc (CYP11A1) in interaction with adrenodoxin
    N V Strushkevich
    Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus, ul Kuprevicha5, 220141 Minsk, Belarus
    Biochemistry (Mosc) 70:664-71. 2005
    ....
  74. ncbi Anabaena flavodoxin as an electron carrier from photosystem I to ferredoxin-NADP+ reductase. Role of flavodoxin residues in protein-protein interaction and electron transfer
    Isabel Nogues
    Departamento de Bioquimica y Biologia Molecular y Celular, Facultad de Ciencias, and Institute of Biocomputation and Physics of Complex Systems BIFI, Facultad de Ciencias, Universidad de Zaragoza, 50009 Zaragoza, Spain
    Biochemistry 44:97-104. 2005
    ..Mutants at these Fld positions indicate that residues in the close environment of the isoalloxazine ring modulate the ability of Fld to bind to and to exchange electrons with its physiological counterparts...
  75. ncbi Amino acid residues in Anabaena ferredoxin crucial to interaction with ferredoxin-NADP+ reductase: site-directed mutagenesis and laser flash photolysis
    J K Hurley
    Department of Biochemistry, University of Arizona, Tucson 85721
    Biochemistry 32:9346-54. 1993
    ..Several mutations at other sites in the vicinity of E94 and F65 (R42, T48, D68, and D69) resulted in little or no perturbation of the Fd/FNR interaction.(ABSTRACT TRUNCATED AT 250 WORDS)..
  76. ncbi Role of a cluster of hydrophobic residues near the FAD cofactor in Anabaena PCC 7119 ferredoxin-NADP+ reductase for optimal complex formation and electron transfer to ferredoxin
    M Martinez-Julvez
    Departamento de Bioquimica y Biologia Molecular y Celular, Facultad de Ciencias, Universidad de Zaragoza, 50009 Zaragoza, Spain
    J Biol Chem 276:27498-510. 2001
    ..These results are consistent with the structure reported for the Anabaena FNR.Fd complex...
  77. ncbi Towards a new interaction enzyme:coenzyme
    Marta Martinez-Julvez
    Departamento de Bioquímica y Biología Molecular y Celular and Institute of Biocomputation and Physics of Complex Systems BiFi, Facultad de Ciencias, Universidad de Zaragoza, 50009 Zaragoza, Spain
    Biophys Chem 115:219-24. 2005
    ..Additionally, giving the role stated for the C-terminal Tyr in FNR, its role in the energetics of the FAD binding has been analysed...
  78. ncbi Polymorphisms of genes involved in homocysteine metabolism in preeclampsia and in uncomplicated pregnancies
    Eva Also-Rallo
    Department of Genetics of the University of Barcelona, Spain
    Eur J Obstet Gynecol Reprod Biol 120:45-52. 2005
    ..To evaluate the possible relationship between preeclampsia and polymorphisms in the main genes involved in folate-homocysteine metabolism...
  79. ncbi Relationship between polymorphisms in genes involved in homocysteine metabolism and maternal risk for Down syndrome in Brazil
    Luciana Rodrigues Jacy da Silva
    Centro de Genetica Medica, Departamentos de Morfologia e Pediatria, UNIFESP EPM, Sao Paulo, Brazil
    Am J Med Genet A 135:263-7. 2005
    ..05). However, when the presence of 677T, 1298C, 2756G, 66G, and 844ins68 alleles were evaluated together, the mothers of children with DS tend to have a higher number of uncommon alleles than the mothers with no previous affected child...
  80. ncbi Adrenodoxin: structure, stability, and electron transfer properties
    A V Grinberg
    Naturwissenschaftlich Technische Fakultät III, Fachrichtung 8 8 Biochemie, Universitat des Saarlandes, Saarbrucken, Germany
    Proteins 40:590-612. 2000
    ..The discussion will be largely centered on the protein-protein recognition and kinetics of adrenodoxin dependent reactions...
  81. ncbi Cyclic electron flow in C3 plants
    Pierre Joliot
    CNRS UMR 7141, Institut de Biologie Physico Chimique, 13, rue Pierre et Marie Curie, 75005 Paris, France
    Biochim Biophys Acta 1757:362-8. 2006
    ..Lack of CO2 is associated with an increase in the efficiency of the cyclic flow. ATP concentration could be one of the parameters that control the transition between linear and cyclic modes...
  82. ncbi Refined X-ray structures of the oxidized, at 1.3 A, and reduced, at 1.17 A, [2Fe-2S] ferredoxin from the cyanobacterium Anabaena PCC7119 show redox-linked conformational changes
    R Morales
    Laboratoire de Cristallographie et de Cristallogenese des Proteines, Laboratoire d Enzymologie Moleculaire, and Laboratoire de Spectrométrie de Masse, Institut de Biologie Structurale J P Ebel, CEA CNRS, 41 rue Jules Horowitz, France
    Biochemistry 38:15764-73. 1999
    ..Superposition of the three crystallographically independent molecules shows that the putative recognition site with the physiological partner (FNR) involves charged, hydrophobic residues and invariant water molecules...
  83. ncbi Polymorphisms of genes controlling homocysteine levels and IQ score following the treatment for childhood ALL
    Maja Krajinovic
    Hopital Sainte Justine, Service d hématologie oncologie, Centre de Recherche, 3175 Cote Sainte Catherine, Montreal, Quebec H3T 1C5, Canada
    Pharmacogenomics 6:293-302. 2005
    ..Several enzymes are essential to maintain the homocysteine levels. Their different functional forms, associated with common genetic polymorphisms, may modulate homocysteine levels and thereby influence MTX-associated neurotoxicity...
  84. ncbi Ferredoxin-NADP+ reductase. Kinetics of electron transfer, transient intermediates, and catalytic activities studied by flash-absorption spectroscopy with isolated photosystem I and ferredoxin
    Nicolas Cassan
    Service de Bioénergétique and CNRS URA 2096, Departement de Biologie Joliot Curie, CEA Saclay, 91191 Gif sur Yvette, France
    J Biol Chem 280:25960-72. 2005
    ..Identical rates were found with photosystem I lacking the PsaE subunit and wild type photosystem I. This suggests that, in contrast with previous proposals, the PsaE subunit is not involved in NADP+ photoreduction...
  85. ncbi Association and redox properties of the putidaredoxin reductase-nicotinamide adenine dinucleotide complex
    Vytas Reipa
    National Institute of Standards and Technology, 100 Bureau Drive, Gaithersburg, Maryland, USA
    Biochemistry 46:13235-44. 2007
    ..These results are integrated with known structural and kinetic information for PdR, as well as for AdR and FNR, in support of a compulsory ordered pathway to describe the electron-transfer processes catalyzed by all three reductases...
  86. ncbi Changes in the mode of electron flow to photosystem I following chilling-induced photoinhibition in a C3 plant, Cucumis sativus L
    Sridharan Govindachary
    Groupe de Recherche en Biologie Végétale, Universite du Quebec a Trois Rivieres, C P 500, Trois Rivieres, QC, Canada, G9A 5H7
    Photosynth Res 94:333-45. 2007
    ....
  87. ncbi The sequence of squash NADH:nitrate reductase and its relationship to the sequences of other flavoprotein oxidoreductases. A family of flavoprotein pyridine nucleotide cytochrome reductases
    G E Hyde
    Phytotechnology Research Center, Michigan Technological University, Houghton 49931
    J Biol Chem 266:23542-7. 1991
    ..We suggest that this family of flavoenzymes, nearly all of which reduce a hemoprotein, be called "flavoprotein pyridine nucleotide cytochrome reductases."..
  88. ncbi Analysis of donors of electrons to photosystem I and cyclic electron flow by redox kinetics of P700 in chloroplasts of isolated bundle sheath strands of maize
    Boris Ivanov
    Institute of Basic Biological Problems, Russian Academy of Sciences, Pushchino, 142290, Russia
    Photosynth Res 92:65-74. 2007
    ..NDH may contribute to redox poising of CEF1, or function to generate ATP in linear electron flow to O2 via PSI, utilizing NADPH generated from malate by chloroplastic NADP-ME...
  89. ncbi Mutagenesis of Glycine 179 modulates both catalytic efficiency and reduced pyridine nucleotide specificity in cytochrome b5 reductase
    Glenn W Roma
    Department of Biochemistry and Molecular Biology, College of Medicine and the H Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, Florida 33612, USA
    Biochemistry 44:13467-76. 2005
    ....
  90. ncbi Roles of divalent metal ions in oxidations catalyzed by recombinant cytochrome P450 3A4 and replacement of NADPH--cytochrome P450 reductase with other flavoproteins, ferredoxin, and oxygen surrogates
    H Yamazaki
    Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146, USA
    Biochemistry 34:8380-9. 1995
    ..The reactions could be supported by E. coli cytosol or by purified E. coli flavodoxin and NADPH-flavodoxin reductase. Spinach ferredoxin and NADPH-ferredoxin reductase also supported catalytic activities.(ABSTRACT TRUNCATED AT 250 WORDS)..
  91. ncbi Structural and chemical properties of a flavodoxin from Anabaena PCC 7119
    M F Fillat
    Departamento de Bioquimica y Biologia Molecular y Celular, Facultad de Ciencias, Universidad de Zaragoza, Spain
    Biochim Biophys Acta 1040:301-7. 1990
    ..5-5) x 10(3) min-1); a values similar to that determined for Anabaena ferredoxin. The flavodoxin binds tightly to the reductase with Kd values of 6.4 and 8.5 microM at pH values of 7.0 and 8.0, respectively...
  92. ncbi Purification and crystallization of the cyanobacterial cytochrome b6f complex
    Danas Baniulis
    Department of Biological Sciences, Lilly Hall of Life Sciences, Purdue University, West Lafayette, IN, USA
    Methods Mol Biol 684:65-77. 2011
    ..Well diffracting crystals have been obtained from the green alga, Chlamydomonas reinhardtii (ref. 10)...
  93. pmc Binding of Pseudomonas aeruginosa apobacterioferritin-associated ferredoxin to bacterioferritin B promotes heme mediation of electron delivery and mobilization of core mineral iron
    Saroja K Weeratunga
    Ralph N Adams Institute for Bioanalytical Chemistry, Department of Chemistry, University of Kansas, Lawrence, Kansas 66047, USA
    Biochemistry 48:7420-31. 2009
    ..In the presence of sodium dithionite or in the presence of P. aeruginosa ferredoxin NADP reductase (FPR) and NADPH, the heme in BfrB remains oxidized, and the core iron mineral is mobilized sluggishly...
  94. ncbi Photoinduced hydrogen production by direct electron transfer from photosystem I cross-linked with cytochrome c3 to [NiFe]-hydrogenase
    Masaki Ihara
    Bioengineering, RIKEN, 2 1 Hirosawa, Wako 351 0198, Japan
    Photochem Photobiol 82:1677-85. 2006
    ..30 pmol Hz/mg chlorophyll/h). These results suggest that the cytc3/PSI complex may produce H2 in vivo...
  95. ncbi The reaction center of green sulfur bacteria(1)
    G Hauska
    Lehstuhl für Zellbiologie und Pflanzenphysiologie, Universitat Regensburg, Germany
    Biochim Biophys Acta 1507:260-77. 2001
    ..Furthermore, it is still unclear which cytochrome c is the physiological electron donor to P840(+). Also the way of NAD(+)-reduction is unknown, since a gene equivalent to ferredoxin-NADP(+) reductase is not present in the genome...
  96. ncbi Four crystal structures of the 60 kDa flavoprotein monomer of the sulfite reductase indicate a disordered flavodoxin-like module
    A Gruez
    Laboratoire de Cristallographie et Cristallogenèse des Protéines Institut de Biologie Structurale J P Ebel, CEA CNRS, Grenoble, France
    J Mol Biol 299:199-212. 2000
    ..Thus, a movement of the FMN-binding domain relative to the rest of the enzyme may be a requirement for its optimal positioning relative to both the FNR-like module and the beta-subunit...
  97. ncbi Structural and mechanistic aspects of flavoproteins: photosynthetic electron transfer from photosystem I to NADP+
    Milagros Medina
    Departamento de Bioquímica y Biología Molecular y Celular and BFIF, Universidad de Zaragoza, Spain
    FEBS J 276:3942-58. 2009
    ..Better knowledge of these systems and their particular properties may allow us to envisage several interesting applications of these proteins beyond their physiological functions...
  98. ncbi Reaction of the NAD(P)H:flavin oxidoreductase from Escherichia coli with NADPH and riboflavin: identification of intermediates
    V Niviere
    Laboratoire de Chimie et Biochimie des Centres Redox Biologiques, DBMS CEA, CNRS, Grenoble, France
    Biochemistry 37:11879-87. 1998
    ..These results support the initial hypothesis of a structural similarity between flavin reductase and the enzymes of the ferredoxin-NADP+ reductase family and extend it at a functional level...
  99. ncbi Antiplasmodial activity of quinones: roles of aziridinyl substituents and the inhibition of Plasmodium falciparum glutathione reductase
    Philippe Grellier
    Museum national d histoire naturelle, FRE 3206 CNRS, 61 rue Buffon, Paris Cedex 05, France
    Arch Biochem Biophys 494:32-9. 2010
    ..falciparum GR inhibitors, which was revealed using multiparameter regression analysis. To our knowledge, this is the first quantitative demonstration of a link between the antiplasmodial activity of compounds and GR inhibition...
  100. ncbi Nitroreductase reactions of Arabidopsis thaliana thioredoxin reductase
    V Miskiniene
    Institute of Biochemistry, Mokslininku 12, Vilnius, Lithuania
    Biochim Biophys Acta 1366:275-83. 1998
    ..Our data indicate that certain nitroaromatic herbicides, explosives and other classes of xenobiotics may interfere with the reduction of thioredoxin by plant TR, and confer prooxidant properties to this antioxidant enzyme...
  101. ncbi Acclimation of photosynthesis to nitrogen deficiency in Phaseolus vulgaris
    Taras Antal
    Molecular Plant Biology, Department of Biochemistry and Food Chemistry, University of Turku, Turku, Finland
    Planta 232:887-98. 2010
    ..As a fourth response, the proportion of non-Q(B)-reducing photosystem II reaction centers increased and the redox potential of the Q(B)/Q(B)(-) pair decreased by 25 mV in a fraction of photosystem II centers of nitrogen starved plants...

Research Grants9

  1. 7 FE FDI AS A MODEL FE-S AND REGULATORY PROTEIN
    Thomas Poulos; Fiscal Year: 2002
    ..g. superoxide, NO). ..
  2. Thermodynamic Properties of NADH:Nitrate Reductase
    Michael Barber; Fiscal Year: 2005
    ..These studies will enhance our understanding of important structure-function relationships in NR and other related metalloflavoproteins. ..
  3. FLAVIN-PROTEIN INTERACTIONS IN FLAVOENZYME CATALYSIS
    Gordon Tollin; Fiscal Year: 2001
    ..These studies, along with x-ray structure determinations of mutant proteins, should provide information on et pathways and distance and orientation effects on flavin-heme electron transfer. ..
  4. IODINE METABOLISM OF THE THYROID GLAND
    ISADORE ROSENBERG; Fiscal Year: 1990
    ....
  5. Epidemiologic Study of Placental Abruption
    Cande Ananth; Fiscal Year: 2006
    ..It will also add substantial new evidence for associations of several genetic thrombophilias and abruption risk. ..
  6. ANDROGEN PRODUCTION IN ADRENARCHE AND PCOS
    WALTER MILLER; Fiscal Year: 2006
    ..abstract_text> ..
  7. Structure/Function Studies on Flavoproteins
    Irina Sevrioukova; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  8. Gene-Nutrient Interactions and Breast Cancer
    SUSAN STECK; Fiscal Year: 2007
    ..abstract_text> ..
  9. Role of CRH in skin physiology and pathology
    Andrzej Slominski; Fiscal Year: 2004
    ..g., melanocytes and keratinocytes, and test the role of CRH/CRH-R1 axis in the regulation of human hair growth. ..