amino acid oxidoreductases

Summary

Summary: A class of enzymes that catalyze oxidation-reduction reactions of amino acids. EC 1.4.-.

Top Publications

  1. ncbi Ethylene biosynthesis and action in tomato: a model for climacteric fruit ripening
    Lucille Alexander
    Plant Science Division, School of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough LE12 5RD, UK
    J Exp Bot 53:2039-55. 2002
  2. pmc Role of Lysyl oxidase-like 1 gene polymorphisms in Pakistani patients with pseudoexfoliative glaucoma
    Shazia Micheal
    Department of Biosciences, Faculty of Science, COMSATS Institute of Information Technology, Islamabad, Pakistan
    Mol Vis 18:1040-4. 2012
  3. ncbi An investigation into LOXL1 variants in black South African individuals with exfoliation syndrome
    Robyn M Rautenbach
    Ophthalmology Department, Stellenbosch University and Tygerberg Academic Hospital, Tygerberg 7505, South Africa
    Arch Ophthalmol 129:206-10. 2011
  4. pmc Major LOXL1 risk allele is reversed in exfoliation glaucoma in a black South African population
    Susan E I Williams
    Division of Ophthalmology, Department of Neurosciences, University of the Witwatersrand, Johannesburg, South Africa
    Mol Vis 16:705-12. 2010
  5. ncbi Allosteric inhibition of lysyl oxidase-like-2 impedes the development of a pathologic microenvironment
    Vivian Barry-Hamilton
    Arresto BioSciences, Palo Alto, California, USA
    Nat Med 16:1009-17. 2010
  6. ncbi Analysis of LOXL1 single nucleotide polymorphisms in Polish population with pseudoexfoliation syndrome
    Grazyna Malukiewicz
    Department of Ophthalmology, the Nicolaus Copernicus University, Ludwik Rydygier s Collegium Medicum, Bydgoszcz, Poland
    Acta Ophthalmol 89:e64-6. 2011
  7. ncbi Snake venom L-amino acid oxidases
    Xiao Yan Du
    Theodor Kocher Institute, University of Berne, Freiestrasse 1, CH 3012 Berne, Switzerland
    Toxicon 40:659-65. 2002
  8. pmc Association of lysyl oxidase-like 1 gene polymorphisms with exfoliation syndrome in Koreans
    Min Sagong
    Department of Ophthalmology, Yeungnam University College of Medicine, Daegu, Korea
    Mol Vis 17:2808-17. 2011
  9. ncbi Prevalence of high-risk alleles in the LOXL1 gene and its association with pseudoexfoliation syndrome and exfoliation glaucoma in a Latin American population
    Martha Jaimes
    Department of Genetics Research Unit, Institute of Ophthalmology Conde de Valenciana Mexico City, Mexico
    Ophthalmic Genet 33:12-7. 2012
  10. ncbi Secreted LOXL2 is a novel therapeutic target that promotes gastric cancer metastasis via the Src/FAK pathway
    Liang Peng
    State Key Laboratory of Molecular Oncology, Cancer Institute Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People s Republic of China
    Carcinogenesis 30:1660-9. 2009

Research Grants

Detail Information

Publications225 found, 100 shown here

  1. ncbi Ethylene biosynthesis and action in tomato: a model for climacteric fruit ripening
    Lucille Alexander
    Plant Science Division, School of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough LE12 5RD, UK
    J Exp Bot 53:2039-55. 2002
    ....
  2. pmc Role of Lysyl oxidase-like 1 gene polymorphisms in Pakistani patients with pseudoexfoliative glaucoma
    Shazia Micheal
    Department of Biosciences, Faculty of Science, COMSATS Institute of Information Technology, Islamabad, Pakistan
    Mol Vis 18:1040-4. 2012
    ..Therefore the aim of the present study was to investigate the association of these two coding LOXL1 SNPs in Pakistani PEXG patients...
  3. ncbi An investigation into LOXL1 variants in black South African individuals with exfoliation syndrome
    Robyn M Rautenbach
    Ophthalmology Department, Stellenbosch University and Tygerberg Academic Hospital, Tygerberg 7505, South Africa
    Arch Ophthalmol 129:206-10. 2011
    ..To investigate the association between 2 lysyl oxidase-like 1 (LOXL1) polymorphisms, rs1048661 (R141L) and rs3825942 (G153D), and exfoliation syndrome (XFS) in black South African individuals...
  4. pmc Major LOXL1 risk allele is reversed in exfoliation glaucoma in a black South African population
    Susan E I Williams
    Division of Ophthalmology, Department of Neurosciences, University of the Witwatersrand, Johannesburg, South Africa
    Mol Vis 16:705-12. 2010
    ..To investigate whether variants in the lysyl oxidase-like 1 (LOXL1) gene are associated with exfoliation glaucoma (XFG) and primary open-angle glaucoma (POAG) in an ancestral population from South Africa...
  5. ncbi Allosteric inhibition of lysyl oxidase-like-2 impedes the development of a pathologic microenvironment
    Vivian Barry-Hamilton
    Arresto BioSciences, Palo Alto, California, USA
    Nat Med 16:1009-17. 2010
    ..AB0023 outperformed the small-molecule lysyl oxidase inhibitor beta-aminoproprionitrile. The efficacy and safety of LOXL2-specific AB0023 represents a new therapeutic approach with broad applicability in oncologic and fibrotic diseases...
  6. ncbi Analysis of LOXL1 single nucleotide polymorphisms in Polish population with pseudoexfoliation syndrome
    Grazyna Malukiewicz
    Department of Ophthalmology, the Nicolaus Copernicus University, Ludwik Rydygier s Collegium Medicum, Bydgoszcz, Poland
    Acta Ophthalmol 89:e64-6. 2011
    ..To assess the possible association of lysyl oxidase-like 1 (LOXL1) gene variants with pseudoexfoliation syndrome (PEX) in Polish population...
  7. ncbi Snake venom L-amino acid oxidases
    Xiao Yan Du
    Theodor Kocher Institute, University of Berne, Freiestrasse 1, CH 3012 Berne, Switzerland
    Toxicon 40:659-65. 2002
    ..In addition, the putative mechanisms of SV-LAAO-induced platelet aggregation and apoptosis of cells are discussed in more detail...
  8. pmc Association of lysyl oxidase-like 1 gene polymorphisms with exfoliation syndrome in Koreans
    Min Sagong
    Department of Ophthalmology, Yeungnam University College of Medicine, Daegu, Korea
    Mol Vis 17:2808-17. 2011
    ..To evaluate the association of the lysyl oxidase-like 1 (LOXL1) single nucleotide polymorphisms (SNPs) in the Korean population with exfoliation syndrome (XFS) and to investigate the association between the SNPs and phenotypes of XFS...
  9. ncbi Prevalence of high-risk alleles in the LOXL1 gene and its association with pseudoexfoliation syndrome and exfoliation glaucoma in a Latin American population
    Martha Jaimes
    Department of Genetics Research Unit, Institute of Ophthalmology Conde de Valenciana Mexico City, Mexico
    Ophthalmic Genet 33:12-7. 2012
    ..The purpose of this study was to report the results of the first association study between LOXL1 polymorphisms and XFS and/or XFG in a Latin American population...
  10. ncbi Secreted LOXL2 is a novel therapeutic target that promotes gastric cancer metastasis via the Src/FAK pathway
    Liang Peng
    State Key Laboratory of Molecular Oncology, Cancer Institute Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People s Republic of China
    Carcinogenesis 30:1660-9. 2009
    ..Overall, our data revealed that LOXL2 overexpression, a frequent event in gastric carcinoma progression, contributes to tumor cell invasion and metastasis, and LOXL2 may be a therapeutic target for preventing and treating metastases...
  11. pmc Analysis of LOXL1 polymorphisms in a Saudi Arabian population with pseudoexfoliation glaucoma
    Khaled K Abu-Amero
    Ophthalmic Genetics Laboratory, College of Medicine, King Saud University, Riyadh, Saudi Arabia
    Mol Vis 16:2805-10. 2010
    ..To investigate whether single nucleotide polymorphisms (SNPs) in the lysyl oxidase-like 1 (LOXL1) gene are associated with pseudoexfoliation glaucoma (PEG) in the Saudi Arabian population...
  12. ncbi Vaccination strategy to target lysyl oxidase-like 4 in dendritic cell based immunotherapy for head and neck cancer
    Jan Bernd Weise
    Department of Otorhinolaryngology, Head and Neck Surgery, University of Kiel, Arnold Heller Strasse 14, Kiel, Germany
    Int J Oncol 32:317-22. 2008
    ....
  13. ncbi LOXL4 as a selective molecular marker in primary and metastatic head/neck carcinoma
    Nina Scola
    Department of Dermatology and Allergology, Ruhr University Bochum, Gudrunstr 56, 44791 Bochum, Germany
    Anticancer Res 30:4567-71. 2010
    ..The overexpression of EGFR has been well examined and already serves as a therapeutic target. The expression of both genes was compared in head and neck squamous cell carcinomas and their diagnostic and prognostic value was evaluated...
  14. pmc The antimicrobial activity of marinocine, synthesized by Marinomonas mediterranea, is due to hydrogen peroxide generated by its lysine oxidase activity
    Patricia Lucas-Elio
    Department of Genetics and Microbiology, Faculty of Biology, University of Murcia, 30100 Murcia, Spain
    J Bacteriol 188:2493-501. 2006
    ..This is the first report on a bacterial lysine oxidase activity and the first time that a gene encoding this activity has been cloned...
  15. pmc Association of LOXL1 gene polymorphisms with exfoliation syndrome/glaucoma and primary open angle glaucoma in a Turkish population
    Burcu Kasım
    Department of Ophthalmology, Hacettepe University School of Medicine, Ankara, Turkey
    Mol Vis 19:114-20. 2013
    ..To investigate the association of lysyl oxidase like 1 (LOXL1) variants with exfoliation syndrome (XFS), exfoliation glaucoma (XFG), and primary open angle glaucoma (POAG) in a Turkish population...
  16. ncbi Cloning and sequence analysis of a cDNA for barley ferredoxin-dependent glutamate synthase and molecular analysis of photorespiratory mutants deficient in the enzyme
    C Avila
    Biochemistry and Physiology Department, Rothamsted Experimental Station, AFRC Institute of Arable Crops Research, Harpenden, Herts, UK
    Planta 189:475-83. 1993
    ..7 kb, the other smaller. Using a set of wheat-barley telosomic addition lines we have assigned the Fd-GOGAT structural locus to the short arm of chromosome 2...
  17. pmc Evaluation of lysyl oxidase-like 1 gene polymorphisms in pseudoexfoliation syndrome in a Korean population
    Do Young Park
    Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Mol Vis 19:448-53. 2013
    ..The purpose of this study was to evaluate association profiles of lysyl oxidase-like 1 (LOXL1) gene polymorphisms with pseudoexfoliation syndrome (XFS) in a Korean population...
  18. ncbi Partial sequences of nitrogen metabolism genes in hexaploid wheat
    M Boisson
    INRA URGAP, Domaine de Brunehaut, Peronne, BP 136, 80200, Estrées Mons, France
    Theor Appl Genet 110:932-40. 2005
    ..We demonstrate that polymorphism detection enables heterologous, homeologous and even paralogous copies to be assigned, even if the elaboration of specific primer pairs is time-consuming and expensive because of the sequencing...
  19. ncbi Polymorphisms in ARMS2 (LOC387715) and LOXL1 genes in the Japanese with age-related macular degeneration
    Nobuo Fuse
    Department of Ophthalmology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan
    Am J Ophthalmol 151:550-6.e1. 2011
    ..To determine whether polymorphisms in the ARMS2 (LOC387715) gene and the lysyl oxidase-like 1 (LOXL1) gene are associated with age-related macular degeneration (AMD) in Japanese patients...
  20. pmc Arabidopsis gls mutants and distinct Fd-GOGAT genes. Implications for photorespiration and primary nitrogen assimilation
    K T Coschigano
    Department of Biology, 1009 Main Building, New York University, 100 Washington Square East, New York, New York 10003, USA
    Plant Cell 10:741-52. 1998
    ....
  21. ncbi Purification and characterization of a novel glycine oxidase from Bacillus subtilis
    Y Nishiya
    Tsuruga Institute of Biotechnology, Toyobo Co, Ltd, Fukui, Japan
    FEBS Lett 438:263-6. 1998
    ..Several enzymatic properties of the B. subtilis glycine oxidase were also investigated...
  22. ncbi Structural and functional diversity of lysyl oxidase and the LOX-like proteins
    J Molnar
    Department of Allied Medical Sciences, John A Burns School of Medicine, University of Hawaii, 1993 East West Road, Biomed T415, Honolulu, HI 96822, USA
    Biochim Biophys Acta 1647:220-4. 2003
    ..Comparative expression analysis of each LOX protein is presented to help determine their functional significance...
  23. pmc Transcriptional profiling of an Fd-GOGAT1/GLU1 mutant in Arabidopsis thaliana reveals a multiple stress response and extensive reprogramming of the transcriptome
    Ralph Kissen
    Department of Biology, Norwegian University of Science and Technology NTNU, NO 7491 Trondheim, Norway
    BMC Genomics 11:190. 2010
    ..thaliana mutant glu1-2 knocked-down in the expression of Fd-GOGAT1 (GLU1; At5g04140), one of the two genes of A. thaliana encoding ferredoxin-dependent glutamate synthase...
  24. ncbi Association of LOXL1 common sequence variants in German and Italian patients with pseudoexfoliation syndrome and pseudoexfoliation glaucoma
    Francesca Pasutto
    Institute of Human Genetics, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
    Invest Ophthalmol Vis Sci 49:1459-63. 2008
    ..In this study, the genetic association of these variants was investigated in patients with PEX or PEXG of German and Italian descent...
  25. ncbi Lysyl oxidase-like 2 expression is increased in colon and esophageal tumors and associated with less differentiated colon tumors
    Sheri F T Fong
    Cardiovascular Research Center, John A Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI 96822, USA
    Genes Chromosomes Cancer 46:644-55. 2007
    ..These results suggest that increased LOXL2 expression in colon and esophageal cancer may contribute to tumor progression...
  26. pmc 1-aminocyclopropane-1-carboxylate oxidase activity limits ethylene biosynthesis in Rumex palustris during submergence
    W H Vriezen
    Departments of Experimental Botany and Ecology, University of Nijmegen, Toernooiveld 1, 6525 ED, Nijmegen, The Netherlands
    Plant Physiol 121:189-96. 1999
    ..Therefore, ethylene biosynthesis seems to be limited at the level of ACC oxidase activity rather than by ACC synthase in R. palustris during submergence...
  27. pmc Variations in LOXL1 associated with exfoliation glaucoma do not affect amine oxidase activity
    Seonkwan Kim
    Department of Biochemistry, School of Medicine, Wonkwang University, Sinyong Dong 344 2, Iksan City, Jeollabuk Do 570 749, South Korea
    Mol Vis 18:265-70. 2012
    ..To evaluate the impact of the R141L and G153D variations on the amine oxidase activity of LOXL1, we generated four different haplotypes of LOXL1 with R141L and G153D and assessed the amine oxidase activity of the LOXL1 variant proteins...
  28. pmc A genomics approach reveals that aroma production in apple is controlled by ethylene predominantly at the final step in each biosynthetic pathway
    Robert J Schaffer
    Horticulture and Food Research Institute of New Zealand, Mt Albert, Auckland, New Zealand
    Plant Physiol 144:1899-912. 2007
    ..This analysis suggests that the initial and final enzymatic steps with the biosynthetic pathways are important transcriptional regulation points for aroma production in apple...
  29. ncbi Lysyl oxidase-like protein-2 regulates sprouting angiogenesis and type IV collagen assembly in the endothelial basement membrane
    Marine Bignon
    College de France, Center for Interdisciplinary Research in Biology, Paris, France
    Blood 118:3979-89. 2011
    ..Altogether, our study provides the first evidence for the role of LOXL2 in regulating angiogenesis through collagen IV scaffolding...
  30. ncbi Different effects on ACC oxidase gene silencing triggered by RNA interference in transgenic tomato
    Ai Sheng Xiong
    Shanghai Key Laboratory of Agricultural Genetics and Breeding, Agro Biotechnology Research Center, Shanghai Academy of Agricultural Sciences, 2901 Beidi Road, 201106, Shanghai, People s Republic of China
    Plant Cell Rep 23:639-46. 2005
    ..The RNA and protein analyses indicated that there was non-RNA interference, semi-RNA interference and full-RNA interference of ACC oxidase in the transgenic tomato plants...
  31. ncbi Down-regulation of lysyl oxydase-like in aging and venous insufficiency
    G Pascual
    Department of Medical Specialities, Networking Research Center on Biomaterials and Nanomedicine CIBER BBN, Alcala de Henares, Madrid, Spain
    Histol Histopathol 23:179-86. 2008
    ..The effects of age on these expression patterns were also evaluated...
  32. pmc Analysis of proline reduction in the nosocomial pathogen Clostridium difficile
    Sarah Jackson
    Department of Molecular Biology and Microbiology, Burnett College of Biomedical Science, University of Central Florida, Orlando, FL 32816 2364, USA
    J Bacteriol 188:8487-95. 2006
    ..These results show that Stickland reactions are key to the growth of C. difficile and that the mechanism of PR may differ significantly from that of previously studied PR from nonpathogenic species...
  33. pmc Streamlined protein expression and purification using cleavable self-aggregating tags
    Lei Xing
    Department of Chemical Engineering, Tsinghua University, One Tsinghua Garden Road, Beijing 100084, China
    Microb Cell Fact 10:42. 2011
    ..coli), in which the target proteins retain high enzymatic activities. Here we further explore this finding to develop a novel, facile, matrix-free protein expression and purification approach...
  34. pmc Expression of ethylene biosynthetic and receptor genes in rose floral tissues during ethylene-enhanced flower opening
    Jingqi Xue
    Department of Ornamental Horticulture, China Agricultural University, Beijing 100094, China
    J Exp Bot 59:2161-9. 2008
    ..The response of rose flowers to ethylene occurs initially in gynoecia, and ethylene may regulate flower opening mainly through the Rh-ETR3 gene in gynoecia...
  35. ncbi Exogenous ethylene influences flower opening of cut roses (Rosa hybrida) by regulating the genes encoding ethylene biosynthesis enzymes
    Nan Ma
    Department of Ornamental Horticulture and Landscape Architecture, China Agricultural University, Beijing 100094, China
    Sci China C Life Sci 48:434-44. 2005
    ..Additional results indicated that three Rh-ACSs genes were differentially associated with flower opening and senescence as well as wounding..
  36. pmc Analysis of LOXL1 polymorphisms in a United States population with pseudoexfoliation glaucoma
    Pratap Challa
    Department of Ophthalmology, Duke University Eye Center, Durham, NC 27710, USA
    Mol Vis 14:146-9. 2008
    ..To identify if recently described LOXL1 (lysyl oxidase-like 1) polymorphisms are associated with pseudoexfoliation glaucoma (XFG) in a United States (U.S.) Caucasian patient population...
  37. ncbi LOXL1 and LOXL4 are epigenetically silenced and can inhibit ras/extracellular signal-regulated kinase signaling pathway in human bladder cancer
    Guojun Wu
    Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Cancer Res 67:4123-9. 2007
    ..Thus, our current study suggests for the first time that lysyl oxidase-like genes can act as tumor suppressor genes and exert their functions through the inhibition of the Ras/ERK signaling pathway in human bladder cancer...
  38. ncbi Abnormal deposition of collagen around hepatocytes in Wilson's disease is associated with hepatocyte specific expression of lysyl oxidase and lysyl oxidase like protein-2
    Zehava Vadasz
    The Bruce Rappaport Faculty of Medicine, Cancer and Vascular Biology Research Center, Rappaport Family Institute for Research in the Medical Sciences, Technion, Israel Institute of Technology, P O Box 9697, 1 Efron St, 31096 Haifa, Israel
    J Hepatol 43:499-507. 2005
    ..Lysyl-oxidases catalyze the oxidation of lysine residues in collagen and elastin thereby promoting their polymerization. We have studied here the expression of four lysyl-oxidases in normal and diseased human liver...
  39. ncbi Kinetic mechanisms of glycine oxidase from Bacillus subtilis
    Gianluca Molla
    Department of Structural and Functional Biology, University of Insubria, Varese, Italy
    Eur J Biochem 270:1474-82. 2003
    ....
  40. pmc LOXL1 expression in lens capsule tissue specimens from individuals with pseudoexfoliation syndrome and glaucoma
    Tanya T Khan
    Department of Ophthalmology, Duke University Eye Center, Durham, NC 27710, USA
    Mol Vis 16:2236-41. 2010
    ..We also investigated the effects of four glaucoma drug medications on LOXL1 expression in primary human lens epithelial cell cultures to see if they could affect LOXL1 expression...
  41. pmc Clostridium sticklandii, a specialist in amino acid degradation:revisiting its metabolism through its genome sequence
    Nuria Fonknechten
    Institut de Génomique, Genoscope, 2 rue Gaston Cremieux, F 91057 Evry, France
    BMC Genomics 11:555. 2010
    ..With the goal of revisiting its carbon, nitrogen, and energy metabolism, and comparing studies with other clostridia, its genome has been sequenced and analyzed...
  42. pmc LOXL1 promoter haplotypes are associated with exfoliation syndrome in a U.S. Caucasian population
    Bao Jian Fan
    Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    Invest Ophthalmol Vis Sci 52:2372-8. 2011
    ..The purpose of this study was to investigate the disease association of LOXL1 variants spanning the gene region, including the 5' and 3' regulatory regions, in a U.S. Caucasian case-control sample...
  43. pmc Evaluation of LOXL1 polymorphisms in exfoliation syndrome in the Uygur population
    - Mayinu
    Department of Ophthalmology, the First Affiliated Hospital of Xinjiang Medical University, Urumchi, Xinjiang Uygur Autonomous Region, China
    Mol Vis 17:1734-44. 2011
    ..In this study, we evaluate the association profiles of the lysyl oxidase-like 1 (LOXL1) gene polymorphisms with XFS in the Uygur population...
  44. ncbi Glutamate synthase: structural, mechanistic and regulatory properties, and role in the amino acid metabolism
    Akira Suzuki
    Unité de Nutrition Azotée des Plantes, Institut National de la Recherche Agronomique, Route de Saint Cyr, 78026 Versailles Cedex, France
    Photosynth Res 83:191-217. 2005
    ..Fd-glutamate synthase also plays a role that is redundant, in several important aspects, to that played by NADH-glutamate synthase in ammonium assimilation and nitrogen transport...
  45. ncbi Functional analysis of LOXL2 in pancreatic carcinoma
    Felix Ruckert
    Department of Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Technical University Dresden, Fetscherstr 74, 01307, Dresden, Germany
    Int J Colorectal Dis 25:303-11. 2010
    ..To get more insight into the aggressive growth and infiltrating nature of pancreatic cancer, we evaluated the functional role of LOXL2 in pancreatic cancer cells...
  46. ncbi Bladder and urethral function in pelvic organ prolapsed lysyl oxidase like-1 knockout mice
    Guiming Liu
    Glickman Urological Institute and Department of Biomedical Engineering, Cleveland Clinic, Cleveland, OH 44195, USA
    BJU Int 100:414-8. 2007
    ..To examine bladder and urethral function in pelvic organ prolapsed lysyl oxidase like-1 (LOXL1) knockout mice...
  47. ncbi LOXL1 deficiency in the lamina cribrosa as candidate susceptibility factor for a pseudoexfoliation-specific risk of glaucoma
    Ursula Schlötzer-Schrehardt
    Department of Ophthalmology, University of Erlangen Nurnberg, Erlangen, Germany
    Ophthalmology 119:1832-43. 2012
    ....
  48. pmc Lack of association between LOXL1 gene polymorphisms and primary open angle glaucoma in the Saudi Arabian population
    Khaled K Abu-Amero
    Ophthalmic Genetics Laboratory, Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia
    Ophthalmic Genet 33:130-3. 2012
    ..To investigate whether major single nucleotide polymorphisms (SNPs) in the LOXL1 gene associated with pseudoexfoliation glaucoma are associated with primary open angle glaucoma (POAG) in the Saudi Arabian population...
  49. ncbi Atomic force microscopy-based antibody recognition imaging of proteins in the pathological deposits in pseudoexfoliation syndrome
    Rhiannon Creasey
    School of Chemical and Physical Sciences, Flinders University of SA, GPO Box 2100, Adelaide, SA 5001, Australia
    Ultramicroscopy 111:1055-61. 2011
    ..Our evaluation shows that TREC imaging is best suited for human tissue imaging and holds significant potential for imaging of human disease tissues in their native state...
  50. ncbi The human lysyl oxidase-like 2 protein functions as an amine oxidase toward collagen and elastin
    Young Mi Kim
    Department of Biochemistry, School of Medicine, Wonkwang University, Iksan, Jeonbuk, 570 749, Korea
    Mol Biol Rep 38:145-9. 2011
    ..Further, amine oxidase activity of LOXL2 was not susceptible to inhibition by β-aminopropionitrile, an irreversible inhibitor of LOX, suggesting a different enzymatic mechanism between these two paralogues...
  51. pmc The role of lysyl oxidase-like 1 DNA copy number variants in exfoliation glaucoma
    Yutao Liu
    Center for Human Genetics, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Mol Vis 18:2976-81. 2012
    ..To investigate whether DNA copy number variants (CNVs) in the lysyl oxidase-like 1 (LOXL1) gene are associated with exfoliation glaucoma (XFG) in black South Africans...
  52. pmc Increased choroidal neovascularization following laser induction in mice lacking lysyl oxidase-like 1
    Hyeong Gon Yu
    Angiogenesis Laboratory and Laser Laboratory, Retina Research Institute, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    Invest Ophthalmol Vis Sci 49:2599-605. 2008
    ..This study investigated the influence of defective elastic fiber maintenance in the development of laser-induced CNV...
  53. ncbi The management of exfoliative glaucoma
    Robert Ritch
    New York Eye and Ear Infirmary, New York, New York 10003, USA
    Prog Brain Res 173:211-24. 2008
    ..This discovery should open the way to new approaches and directions of therapy for this protein disorder...
  54. ncbi Purification of enzymatically active human lysyl oxidase and lysyl oxidase-like protein from Escherichia coli inclusion bodies
    Sang Taek Jung
    Laboratory of Functional Proteomics, Samyang Genex Biotechnology Research Institute, 63 2, Hwaam Dong, Yusung Gu, Daejeon City, Republic of Korea
    Protein Expr Purif 31:240-6. 2003
    ..Availability of these pure and active forms of LOX and LOXLs will be significantly helpful in functional studies related to substrate specificity and crystal structures of this family of amine oxidases...
  55. ncbi Molecular biology of pyridine nucleotide biosynthesis in Escherichia coli. Cloning and characterization of quinolinate synthesis genes nadA and nadB
    R Flachmann
    Institut fur Biochemie, Technische Hochschule Darmstadt, Federal Republic of Germany
    Eur J Biochem 175:221-8. 1988
    ..High-copy-number vectors, carrying either gene nadA, nadB or nadA + nadB, increased quinolinate production 1.5-fold, 2.0-fold and 15-fold respectively. Both gene products seem to be equally rate-limiting in quinolinate synthesis...
  56. ncbi Systematic screening of lysyl oxidase-like (LOXL) family genes demonstrates that LOXL2 is a susceptibility gene to intracranial aneurysms
    Hiroyuki Akagawa
    Division of Genetic Diagnosis, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Hum Genet 121:377-87. 2007
    ..In conclusion, one SNP of LOXL2 showed a significant association with IA individually, and we also detected a gene-gene interaction of LOXL2 with ELN/LIMK1, which may play an important role in susceptibility to IA...
  57. ncbi Association of LOXL1 gene polymorphisms with pseudoexfoliation in the Japanese
    Mineo Ozaki
    Ozaki Eye Hospital and Dept of Ophthalmology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan
    Invest Ophthalmol Vis Sci 49:3976-80. 2008
    ..The purpose of this study was to test this association in Japanese subjects with XFS/XFG...
  58. ncbi Molecular pathology of pseudoexfoliation syndrome/glaucoma--new insights from LOXL1 gene associations
    Ursula Schlötzer-Schrehardt
    Department of Ophthalmology, University of Erlangen Nurnberg, Erlangen, Germany
    Exp Eye Res 88:776-85. 2009
    ....
  59. pmc Ethnicity-based subgroup meta-analysis of the association of LOXL1 polymorphisms with glaucoma
    Haoyu Chen
    Joint Shantou International Eye Center, Shantou University and The Chinese University of Hong Kong, Shantou, China
    Mol Vis 16:167-77. 2010
    ..To investigate the association and ethnic heterogeneity of lysyl oxidase-like 1 (LOXL1) single nucleotide polymorphisms (SNPs) with exfoliation syndrome (XFS)/exfoliation glaucoma (XFG) and other types of glaucoma...
  60. ncbi Effect of down-regulation of ethylene biosynthesis on fruit flavor complex in apple fruit
    Abhaya M Dandekari
    Department of Pomology, University of California, I Shields Ave, Davis, CA 95616, USA
    Transgenic Res 13:373-84. 2004
    ....
  61. pmc Differential expression and internal feedback regulation of 1-aminocyclopropane-1-carboxylate synthase, 1-aminocyclopropane-1-carboxylate oxidase, and ethylene receptor genes in tomato fruit during development and ripening
    A Nakatsuka
    Laboratory of Postharvest Agriculture, Faculty of Agriculture, Okayama University, Tsushima, Okayama, 700 8530 Japan
    Plant Physiol 118:1295-305. 1998
    ..This transition from system 1 to system 2 ethylene production might be related to the accumulated level of NR mRNA...
  62. pmc Evaluation of LOXL1 polymorphisms in exfoliation syndrome in a Chinese population
    Ling Chen
    Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Science Key Lab, Beijing, China
    Mol Vis 15:2349-57. 2009
    ..To evaluate the association profiles of the lysyl oxidase-like 1 (LOXL1) gene polymorphisms with exfoliation syndrome in a Chinese population...
  63. ncbi Local DNA features affect RNA-directed transcriptional gene silencing and DNA methylation
    Ute Fischer
    Leibniz Institute of Plant Genetics and Crop Plant Research IPK, Corrensstrasse 3, 06466 Gatersleben, Germany
    Plant J 53:1-10. 2008
    ..Apparently, close-by repeats promoted, whereas close-by functional genes diminished, the response to the silencing signal...
  64. pmc Transforming growth factor-beta induces extracellular matrix protein cross-linking lysyl oxidase (LOX) genes in human trabecular meshwork cells
    Anirudh Sethi
    Department of Cell Biology and Anatomy, North Texas Eye Research Institute, University of North Texas Health Science Center, Fort Worth, Texas 76107, USA
    Invest Ophthalmol Vis Sci 52:5240-50. 2011
    ..The purpose of this study was to determine whether expression of ECM cross-linking LOX genes is regulated by TGFβ in TM cells...
  65. ncbi The glycine decarboxylase system: a fascinating complex
    R Douce
    Departement de Biologie Moleculaire et Structurale, Physiologie Cellulaire Vegetale, CEA Grenoble, CNRS et Université Joseph Fourier, 17 rue des Martyrs, F 38054 Grenoble, Cedex 9, France
    Trends Plant Sci 6:167-76. 2001
    ..Plant mitochondria possess all the necessary enzymatic equipment for de novo synthesis of tetrahydrofolate and lipoic acid, serving as cofactors for glycine decarboxylase and serine hydroxymethyltransferase functioning...
  66. ncbi Peroxidase activity of selenoprotein GrdB of glycine reductase and stabilisation of its integrity by components of proprotein GrdE from Eubacterium acidaminophilum
    Tina Gröbe
    Institute of Chemistry Biochemistry, FU Berlin, Thielallee 63, 14195 Berlin, Germany
    Arch Microbiol 187:29-43. 2007
    ..The GrdB-GrdE interaction was confirmed by copurification of GrdE with Strep-tagged GrdB. The data suggest that GrdE domains serve to stabilise GrdB...
  67. ncbi No association of LOXL1 gene polymorphisms with Alzheimer's disease
    Alexandra Abramsson
    Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
    Neuromolecular Med 13:160-6. 2011
    ..No evidence for associations of these polymorphisms with risk for AD or any of the studied CSF biomarkers measured was found. These results do not support LOXL1 as being a major risk gene for AD...
  68. ncbi Identification of LOXL1 protein and Apolipoprotein E as components of surgically isolated pseudoexfoliation material by direct mass spectrometry
    Shiwani Sharma
    Department of Ophthalmology, Flinders University, Bedford Park, South Australia 5042, Australia
    Exp Eye Res 89:479-85. 2009
    ..In conclusion, additional as yet unknown components are present in pathological PEX deposits and mass spectrometry of "isolated" PEX material is an effective strategy for their identification...
  69. pmc Genetics of pseudoexfoliation syndrome
    Pratap Challa
    Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Curr Opin Ophthalmol 20:88-91. 2009
    ..The purpose of this review is to discuss the inheritance patterns and recent genetic advances in the study of this disorder...
  70. pmc Genotype-correlated expression of lysyl oxidase-like 1 in ocular tissues of patients with pseudoexfoliation syndrome/glaucoma and normal patients
    Ursula Schlötzer-Schrehardt
    Department of Ophthalmology, University of Erlangen Nurnberg, Erlangen, Germany
    Am J Pathol 173:1724-35. 2008
    ..Alterations of LOXL1 activation, processing, and/or substrate specificity may contribute to the abnormal aggregation of elastic fiber components into characteristic PEX fibrils...
  71. ncbi Reduction of LOX- and LOXL2-mRNA expression in head and neck squamous cell carcinomas
    T Rost
    Department of Otolaryngology, University of Marburg, Deutschhausstr 3, 35037 Marburg, Germany
    Anticancer Res 23:1565-73. 2003
    ..The cancer-related functions of both LOX and LOXL2 have not yet been investigated in squamous cell carcinoma of the head and neck (HNSCC)...
  72. ncbi Isolation, purification, and characterization of amadoriase isoenzymes (fructosyl amine-oxygen oxidoreductase EC 1.5.3) from Aspergillus sp
    M Takahashi
    Institute of Pathology, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biol Chem 272:3437-43. 1997
    ..soil strain selected on fructosyl adamantanamine and induced by fructosyl propylamine. In contrast to previous described enzymes, these novel amadoriase enzymes can deglycate both glycated amines and amino acids...
  73. ncbi Receptor activity modifying protein-3 mediates the protumorigenic activity of lysyl oxidase-like protein-2
    Vera Brekhman
    Cancer Research and Vascular Biology Center, The Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, 31096, Israel
    FASEB J 25:55-65. 2011
    ..Our experiments suggest that the protumorigenic effects of LOXL2 are partially mediated by RAMP3 and that RAMP3 inhibitors may function as antitumorigenic agents. -..
  74. pmc Molecular and genetic characterization of a non-climacteric phenotype in melon reveals two loci conferring altered ethylene response in fruit
    Christophe Perin
    Institut National de la Recherche Agronomique, Station de Génétique et d Amélioration des Fruits et Légumes, Domaine St Maurice, Boîte Postale 94, 84143 Montfavet cedex, France
    Plant Physiol 129:300-9. 2002
    ..Five candidate genes (two ACO, two ACS, and ERS) that were localized on the melon genetic map did not exhibit colocalization with Al-3 or Al-4...
  75. pmc Lysyl oxidase-like-2 (LOXL2) is a major isoform in chondrocytes and is critically required for differentiation
    Mussadiq Iftikhar
    Department of Periodontology and Oral Biology, Henry M Goldman School of Dental Medicine, Boston University, Boston, Massachusetts 02118, USA
    J Biol Chem 286:909-18. 2011
    ..LOXL2 promotes chondrocyte differentiation by mechanisms that are likely to include roles as both a regulator and an effector of chondrocyte differentiation...
  76. ncbi Engineered amadoriase II exhibiting expanded substrate range
    Jing Zheng
    Department of Chemical Engineering, Tsinghua University, One Tsinghua Garden Road, Beijing, 100084, China
    Appl Microbiol Biotechnol 86:607-13. 2010
    ..This study suggests that it is possible to manipulate fructosyl amine oxidases to accommodate larger substrates, and that mutant SII-82 might serve as a template for further engineering...
  77. ncbi From epidemiology to lysyl oxidase like one (LOXL1) polymorphisms discovery: phenotyping and genotyping exfoliation syndrome and exfoliation glaucoma in Iceland
    Fridbert Jonasson
    University of Iceland, Landspitali, Reykjavik, Iceland
    Acta Ophthalmol 87:478-87. 2009
    ..These results have now largely been replicated world-wide...
  78. ncbi ACO1, a gene for aminocyclopropane-1-carboxylate oxidase: effects on internode elongation at the heading stage in rice
    M Iwamoto
    Photobiology and Photosynthesis Research Unit, Division of Plant Sciences, National Institute of Agrobiological Sciences, Tsukuba, Ibaraki 305 8602, Japan
    Plant Cell Environ 33:805-15. 2010
    ..This study suggests that the ACO1 has a little effect on internode elongation at the heading stage, and that up-regulation of the ACS1 and OsEIN2 expression may attenuate inhibition of internode elongation...
  79. ncbi Lysyl oxidase-like 2 as a new poor prognosis marker of squamous cell carcinomas
    Hector Peinado
    Departamento de Bioquimica, Instituto de Investigaciones Biomédicas Alberto Sols Consejo Superior de Investigaciones Científicas Universidad Autónoma de Madrid, Universidad Autonoma de Madrid, Madrid, Spain
    Cancer Res 68:4541-50. 2008
    ..Altogether, our results show that LOXL2 can be used as a new poor prognosis indicator in human squamous cell carcinomas promoting malignant transformation by both SNAI1-dependent and SNAI1-independent pathways...
  80. ncbi Lysyl oxidases in mammalian development and certain pathological conditions
    Joni M Maki
    Oulu Centre for Cell Matrix Research, Biocenter Oulu, University of Oulu, Oulu, Finland
    Histol Histopathol 24:651-60. 2009
    ..Modification of the extracellular matrix by lysyl oxidases has been shown to be a critical contributor to the development of various organs and certain pathological conditions...
  81. pmc Aminocyclopropane carboxylic acid synthase is a regulated step in ethylene-dependent induced conifer defense. Full-length cDNA cloning of a multigene family, differential constitutive, and wound- and insect-induced expression, and cellular and subcellular
    Steven G Ralph
    Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z4
    Plant Physiol 143:410-24. 2007
    ..These results suggest that ACS, but not ACO, is a regulated step in ethylene-induced conifer defense...
  82. ncbi Ancestral LOXL1 variants are associated with pseudoexfoliation in Caucasian Australians but with markedly lower penetrance than in Nordic people
    Alex W Hewitt
    Flinders Medical Centre, Department of Ophthalmology, Flinders University, Adelaide, Australia
    Hum Mol Genet 17:710-6. 2008
    ..This strongly suggests that as yet unidentified genetic or environmental factors independent of LOXL1 strongly influence the phenotypic expression of the syndrome...
  83. ncbi Glutamine and alpha-ketoglutarate are metabolite signals involved in nitrate reductase gene transcription in untransformed and transformed tobacco plants deficient in ferredoxin-glutamine-alpha-ketoglutarate aminotransferase
    S Ferrario-Mery
    Unité de Nutrition Azotée des Plantes, INRA de Versailles, France
    Planta 213:265-71. 2001
    ....
  84. ncbi The LOXL1 gene variations are not associated with primary open-angle and primary angle-closure glaucomas
    Subhabrata Chakrabarti
    Kallam Anji Reddy Molecular Genetics Laboratory, LV Prasad Eye Institute, Hyderabad, India
    Invest Ophthalmol Vis Sci 49:2343-7. 2008
    ..This study was conducted to determine the possible involvement of these SNPs in cases of primary open-angle glaucoma (POAG) and primary angle-closure glaucoma (PACG)...
  85. pmc DNA sequence variants in the LOXL1 gene are associated with pseudoexfoliation glaucoma in a U.S. clinic-based population with broad ethnic diversity
    Bao Jian Fan
    Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA
    BMC Med Genet 9:5. 2008
    ....
  86. doi The use of microarray technology in deciphering the cause of genetic eye diseases: LOXL1 and exfoliation syndrome
    Elias I Traboulsi
    Am J Ophthalmol 145:391-3. 2008
  87. ncbi Putative reaction mechanism of heterologously expressed octopine dehydrogenase from the great scallop, Pecten maximus (L)
    Andre Muller
    Institut fur Zoophysiologie, Heinrich Heine Universitat, Dusseldorf, Germany
    FEBS J 274:6329-39. 2007
    ..In addition to orienting the substrate, His212 will act as an acid-base catalyst by donating a proton to the carbonyl group of pyruvate. The acidity of this histidine is further increased by the proximity of Asp329...
  88. pmc Bioinformatic evaluation of L-arginine catabolic pathways in 24 cyanobacteria and transcriptional analysis of genes encoding enzymes of L-arginine catabolism in the cyanobacterium Synechocystis sp. PCC 6803
    Sarah Schriek
    Lehrstuhl für Molekulare Zellphysiologie, Universitat Bielefeld, Universitatsstr, 25, D 33615 Bielefeld, Germany
    BMC Genomics 8:437. 2007
    ..Further, we chose Synechocystis sp. PCC 6803 for a more detailed bioinformatic analysis and for validation of the bioinformatic predictions on L-arginine catabolism with a transcript analysis...
  89. ncbi Solving the enigma of exfoliation glaucoma: a breakthrough in glaucoma research
    Fridbert Jonasson
    Acta Ophthalmol Scand 85:808-9. 2007
  90. ncbi Common sequence variants in the LOXL1 gene confer susceptibility to exfoliation glaucoma
    Gudmar Thorleifsson
    deCODE Genetics Inc, 101 Reykjavik, Iceland
    Science 317:1397-400. 2007
    ..The population-attributable risk is more than 99%. The product of LOXL1 catalyzes the formation of elastin fibers found to be a major component of the lesions in XFG...
  91. pmc Fibulin-5/DANCE has an elastogenic organizer activity that is abrogated by proteolytic cleavage in vivo
    Maretoshi Hirai
    Horizontal Medical Research Organization, Graduate School of Medicine, Kyoto University, Kyoto 606 8501, Japan
    J Cell Biol 176:1061-71. 2007
    ..These data suggest that fibulin-5 could be a novel therapeutic target for elastic fiber regeneration...
  92. ncbi Genetics. High-risk glaucoma gene found in Nordic studies
    Jean Marx
    Science 317:735. 2007
  93. ncbi Progress in understanding pseudoexfoliation syndrome and pseudoexfoliation-associated glaucoma
    Karim F Damji
    Can J Ophthalmol 42:657-8. 2007
  94. ncbi Identification of the last unknown genes in the fermentation pathway of lysine
    Annett Kreimeyer
    CNRS UMR 8030, Genoscope, 91057 Evry Cedex, France
    J Biol Chem 282:7191-7. 2007
    ..We identified twelve bacteria that possess these genes and thus are expected to ferment lysine, and their gene organization is discussed...
  95. ncbi Differential expression of the 1-aminocyclopropane-1-carboxylate oxidase gene family of tomato
    C S Barry
    Department of Physiology and Environmental Science, University of Nottingham, Loughborough, UK
    Plant J 9:525-35. 1996
    ..The physiological role of the differential expression of the ACC oxidase gene family, in relation to the regulation of ethylene synthesis, during these various developmental processes is discussed...
  96. ncbi Identification of D-proline reductase from Clostridium sticklandii as a selenoenzyme and indications for a catalytically active pyruvoyl group derived from a cysteine residue by cleavage of a proprotein
    U C Kabisch
    Institut fur Mikrobiologie, Martin Luther Universitat Halle Wittenberg, Kurt Mothes Strasse 3, D 6099 Halle, Germany
    J Biol Chem 274:8445-54. 1999
    ..prdA and prdB were transcribed together on a transcript of 4.5 kb; prdB was additionally transcribed as indicated by a 0.8-kb mRNA species...
  97. ncbi In vitro processing of the proproteins GrdE of protein B of glycine reductase and PrdA of D-proline reductase from Clostridium sticklandii: formation of a pyruvoyl group from a cysteine residue
    B Bednarski
    , , Halle, Germany
    Eur J Biochem 268:3538-44. 2001
    ..However, the Cys242-->Ala mutant protein was not cleaved indicating a pivotal role of the thiol group of cysteine or hydroxyl group of serine and threonine during the processing of pyruvoyl group-dependent reductases...
  98. ncbi Genetic association of LOXL1 gene variants and exfoliation glaucoma in a Utah cohort
    Xian Yang
    Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA
    Cell Cycle 7:521-4. 2008
    ..This information will potentially guide glaucoma monitoring efforts by targeting individuals whose genetic profiles put them at higher risk for XFG...
  99. ncbi IAA and N(6)-benzyladenine inhibit ethylene-regulated expression of ACC oxidase and ACC synthase genes in mungbean hypocotyls
    J H Kim
    Department of Biology, Yonsei University, Seoul 120 749, The Republic of Korea
    Plant Cell Physiol 42:1056-61. 2001
    ..Based on these results, we suggest that IAA and BA inhibit ethylene action, resulting in suppression of VR-ACO1 expression and induction of VR-ACS1 expression...
  100. pmc Lysyl oxidase-like 1 gene polymorphisms in Japanese patients with primary open angle glaucoma and exfoliation syndrome
    Fumihiko Mabuchi
    Department of Ophthalmology, University of Yamanashi, Yamanashi, Japan
    Mol Vis 14:1303-8. 2008
    ..To assess whether lysyl oxidase-like 1 (LOXL1) polymorphisms are associated with primary open-angle glaucoma (POAG) and exfoliation syndrome (XFS)...
  101. pmc Evaluation of LOXL1 polymorphisms in eyes with exfoliation glaucoma in Japanese
    Nobuo Fuse
    Department of Ophthalmology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Mol Vis 14:1338-43. 2008
    ....

Research Grants22

  1. A New Transient Kinetic Solvent Isotope Effect Approach
    HARVEY FISHER; Fiscal Year: 2006
    ..The validity of our interpretations will in turn be tested by application of our transient-state solvent KIE approach to a number of relevant non-enzymatic reactions whose detailed mechanisms are well established. ..
  2. The Molecular Basis of Pseudoexfoliation Syndrome
    Pratap Challa; Fiscal Year: 2007
    ..The Ophthalmology department at Duke University is an ideal setting for training physician-scientists and has an established track record of strong support for promising clinician-scientists. ..
  3. 9th International Symposium on the Maillard Reaction
    Vincent Monnier; Fiscal Year: 2007
    ..The Proceedings of these symposia are always published: the Proceedings of the 8th International Maillard symposium appearing as Vol. 1043 of the Annals of the New York Academy of Sciences. [unreadable] [unreadable] [unreadable]..
  4. COLLAGEN CROSSLINKING BY THE MAILLARD REACTIOIN IN AGING
    Vincent Monnier; Fiscal Year: 2004
    ..Our approach, we expect, will result in the first comprehensive, hierarchical map of collagen crosslinks that for, during aging. ..
  5. The Functional Analysis of the Coactivator CARM1
    Mark Bedford; Fiscal Year: 2007
    ..abstract_text> ..
  6. KALLIKREINS AS DIAGNOSTIC MARKERS OF OVARIAN CARCINOMA
    Eleftherios Diamandis; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  7. Neuropathology of a Mouse Model for Phenylketonuria
    Jennifer Embury; Fiscal Year: 2008
    ..In addition, she will have continued exposure to and participation in the molecular biological methods of biomedical research through her involvement in the Laipis laboratory. ..
  8. Identifying and Characterizing Readers of the Neural Histone Code
    Mark Bedford; Fiscal Year: 2008
    ..In this study we plan to investigate how this memory code is read. This basic scientific study will clearly impact the fields of drug addiction, mental retardation and aging diseases of the brain. [unreadable] [unreadable] [unreadable]..
  9. Energy metabolism and virulence of Bordetella species
    Imke Schroeder; Fiscal Year: 2008
    ..The relative contributions of cytochrome oxidase to the infectious cycle will be analyzed in Aim 3 using high-resolution animal models of respiratory tract infection. ..
  10. LINKAGE STUDY OF JUVENILE GLAUCOMA
    Janey Wiggs; Fiscal Year: 2008
    ..3) Screen candidate genes located in the RIEG2 region on chromosome 13q14. 4) Correlate mutations in genes known to cause glaucoma with clinical phenotypes. ..
  11. Human Kallikrein 4 (hK4): A New Prostatic Biomarker?
    Eleftherios Diamandis; Fiscal Year: 2003
    ..If successful, our research will contribute to the development of new prostatic biomarkers and possibly, to better diagnosis which may lead to better clinical outcomes and reduced healthcare costs. ..
  12. A New Biomarker for Ovarian Cancer Detection
    Eleftherios Diamandis; Fiscal Year: 2003
    ..In this grant proposal, we describe further studies, which will examine in greater detail, the ability of a test for the amount of this protein in blood to correctly diagnose the presence of ovarian cancer. ..
  13. Role of cytochrome oxidases in Bordetella pathogenesis
    Imke Schroeder; Fiscal Year: 2007
    ..Jeffrey F. Miller as co-investigator. Although this study is exploratory in nature Dr. Miller brings extensive expertise on Bordetella genetics and pathogen-animal host interaction to the project. [unreadable] [unreadable]..
  14. MECHANISMS OF INCONTINENCE FOLLOWING VAGINAL DISTENSION
    Margot S Damaser; Fiscal Year: 2010
    ....
  15. Protein Array Technology for Protein Interaction
    Mark Bedford; Fiscal Year: 2003
    ..In addition, this type of protein-domain array will facilitate the identification of risk factors and chemoprevention targets at the protein level. ..
  16. Studies on p-Cresol Methylhydroxylase
    William McIntire; Fiscal Year: 2004
    ..This information may lead to the development of better treatments for some human afflictions, such as Parkinsonisn, depression, stress, mitochondrial myopathies, and aging. ..
  17. Genetic Studies of Pseudoexfoliation Glaucoma
    Janey Wiggs; Fiscal Year: 2004
    ....
  18. Small Molecule Regulators of Arginine Methyltransferases
    Mark Bedford; Fiscal Year: 2007
    ..Most importantly, the PRMTs are a newly identified family of enzymes that have not yet been tapped as "drugable" targets. ..
  19. Genetic Etiologies of Primary Open Angle Glaucoma
    Janey Wiggs; Fiscal Year: 2009
    ..Specific genetic defects will be correlated with clinical phenotype by investigating familial aggregation of clinical parameters and looking for evidence of gene/gene interactions and how these interactions may influence phenotype. ..
  20. Mechanisms of Female Urinary Incontinence in Diabetes
    Margot Damaser; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  21. FAMILIAL PRIMARY OPEN ANGLE GLAUCOMA
    Janey Wiggs; Fiscal Year: 2004
    ..Initial genome screens to identify genes responsible for two POAG risk factors, ocular hypertension (OHT) and pseudoexfoliation (PEX), will be performed. ..
  22. Regulation of Transcriptional Coactivators by Environmental Estrogens (R21)
    Mark Bedford; Fiscal Year: 2007
    ..The specific aims are to characterize: 1) Biochemically xenoestrogens as co-activator inhibitors; and 2) In vitro xenoestrogens as co-activator inhibitors. [unreadable] [unreadable] [unreadable] [unreadable]..