ceruloplasmin

Summary

Top Publications

  1. ncbi Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the sla mouse
    C D Vulpe
    Howard Hughes Medical Institute and the Department of Medicine, University of California at San Francisco, 94143, USA
    Nat Genet 21:195-9. 1999
  2. ncbi Ceruloplasmin is a NO oxidase and nitrite synthase that determines endocrine NO homeostasis
    Sruti Shiva
    Vascular Medicine Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Chem Biol 2:486-93. 2006
  3. ncbi Clinical utility of copper, ceruloplasmin, and metallothionein plasma determinations in human neurodegenerative patients and their first-degree relatives
    Nathalie Arnal
    INIBIOLP Instituto de Investigac iones Bioquímicas de La Plata, CCT La Plata, CONICET UNLP, Catedra de Bioquimica y Biologia Molecular, Facultad de Ciencias Medicas, Universidad Nacional de La Plata, 60 y 120 1900 La Plata, Argentina
    Brain Res 1319:118-30. 2010
  4. ncbi Reactive oxygen species regulate ceruloplasmin by a novel mRNA decay mechanism involving its 3'-untranslated region: implications in neurodegenerative diseases
    Nisha Tapryal
    Special Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi 110 067, India
    J Biol Chem 284:1873-83. 2009
  5. ncbi Unexpected role of ceruloplasmin in intestinal iron absorption
    Srujana Cherukuri
    Department of Cell Biology, The Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Cell Metab 2:309-19. 2005
  6. ncbi Copper and ceruloplasmin abnormalities in Alzheimer's disease
    George J Brewer
    Department of Human Genetics, University of Michigan, Ann Arbor, 48103, USA
    Am J Alzheimers Dis Other Demen 25:490-7. 2010
  7. pmc Clinical and genetic association of serum ceruloplasmin with cardiovascular risk
    W H Wilson Tang
    Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, 9500 Euclid Ave, Desk J3 4, Cleveland, OH 44195, USA
    Arterioscler Thromb Vasc Biol 32:516-22. 2012
  8. ncbi Role of ceruloplasmin in macrophage iron efflux during hypoxia
    Joydeep Sarkar
    Department of Cell Biology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Biol Chem 278:44018-24. 2003
  9. ncbi Excess of serum copper not related to ceruloplasmin in Alzheimer disease
    R Squitti
    Department of Neuroscience, AFaR Osp Fatebenefratelli, 00186, Rome, Italy
    Neurology 64:1040-6. 2005
  10. pmc Ferroxidase activity is required for the stability of cell surface ferroportin in cells expressing GPI-ceruloplasmin
    Ivana De Domenico
    Department of Pathology, School of Medicine, University of Utah, 50 North Medical Drive, Salt Lake City, UT 84132, USA
    EMBO J 26:2823-31. 2007

Detail Information

Publications319 found, 100 shown here

  1. ncbi Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the sla mouse
    C D Vulpe
    Howard Hughes Medical Institute and the Department of Medicine, University of California at San Francisco, 94143, USA
    Nat Genet 21:195-9. 1999
    ..We describe here a novel gene, Heph, encoding a transmembrane-bound ceruloplasmin homologue that is mutant in the sla mouse and highly expressed in intestine...
  2. ncbi Ceruloplasmin is a NO oxidase and nitrite synthase that determines endocrine NO homeostasis
    Sruti Shiva
    Vascular Medicine Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Chem Biol 2:486-93. 2006
    ..We therefore hypothesized that the multicopper oxidase, ceruloplasmin, could oxidize NO to NO+, with subsequent hydration to nitrite...
  3. ncbi Clinical utility of copper, ceruloplasmin, and metallothionein plasma determinations in human neurodegenerative patients and their first-degree relatives
    Nathalie Arnal
    INIBIOLP Instituto de Investigac iones Bioquímicas de La Plata, CCT La Plata, CONICET UNLP, Catedra de Bioquimica y Biologia Molecular, Facultad de Ciencias Medicas, Universidad Nacional de La Plata, 60 y 120 1900 La Plata, Argentina
    Brain Res 1319:118-30. 2010
    The concentration of plasma copper, ceruloplasmin (CRP), non-ceruloplasmin-bound Cu (NCBC), and metallothioneins (MTs) were studied as putative biomarkers for neurodegenerative diseases in patients and in their first-degree relatives...
  4. ncbi Reactive oxygen species regulate ceruloplasmin by a novel mRNA decay mechanism involving its 3'-untranslated region: implications in neurodegenerative diseases
    Nisha Tapryal
    Special Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi 110 067, India
    J Biol Chem 284:1873-83. 2009
    b>Ceruloplasmin (Cp), a copper-containing protein, plays a significant role in body iron homeostasis as aceruloplasminemia patients and Cp knock-out mice exhibit iron overload in several tissues including liver and brain...
  5. ncbi Unexpected role of ceruloplasmin in intestinal iron absorption
    Srujana Cherukuri
    Department of Cell Biology, The Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Cell Metab 2:309-19. 2005
    ..Ferroxidases are essential for normal iron homeostasis in most organisms. The paralogous vertebrate ferroxidases ceruloplasmin (Cp) and hephaestin (Heph) are considered to have nonidentical functions in iron transport: plasma Cp drives ..
  6. ncbi Copper and ceruloplasmin abnormalities in Alzheimer's disease
    George J Brewer
    Department of Human Genetics, University of Michigan, Ann Arbor, 48103, USA
    Am J Alzheimers Dis Other Demen 25:490-7. 2010
    ..Serum copper and ceruloplasmin were measured by both enzymatic (eCp) and immunologic (iCp) methods in 28 patients with Alzheimer's disease ..
  7. pmc Clinical and genetic association of serum ceruloplasmin with cardiovascular risk
    W H Wilson Tang
    Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, 9500 Euclid Ave, Desk J3 4, Cleveland, OH 44195, USA
    Arterioscler Thromb Vasc Biol 32:516-22. 2012
    b>Ceruloplasmin (Cp) is an acute-phase reactant that is increased in inflammatory diseases and in acute coronary syndromes...
  8. ncbi Role of ceruloplasmin in macrophage iron efflux during hypoxia
    Joydeep Sarkar
    Department of Cell Biology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Biol Chem 278:44018-24. 2003
    ..We have investigated the mechanism of macrophage iron efflux, focusing on the role of ceruloplasmin (Cp), a copper protein with a potent ferroxidase activity that converts Fe2+ to Fe3+ in the presence of ..
  9. ncbi Excess of serum copper not related to ceruloplasmin in Alzheimer disease
    R Squitti
    Department of Neuroscience, AFaR Osp Fatebenefratelli, 00186, Rome, Italy
    Neurology 64:1040-6. 2005
    To assess the role of serum copper in relation to ceruloplasmin and other peripheral markers of inflammation in Alzheimer disease (AD).
  10. pmc Ferroxidase activity is required for the stability of cell surface ferroportin in cells expressing GPI-ceruloplasmin
    Ivana De Domenico
    Department of Pathology, School of Medicine, University of Utah, 50 North Medical Drive, Salt Lake City, UT 84132, USA
    EMBO J 26:2823-31. 2007
    ..in mice and humans with aceruloplasminemia, an iron overload disease due to mutations in the ferroxidase ceruloplasmin (Cp). In the absence of Cp Fpn is rapidly internalized and degraded...
  11. ncbi Ceruloplasmin metabolism and function
    Nathan E Hellman
    Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Annu Rev Nutr 22:439-58. 2002
    b>Ceruloplasmin is a serum ferroxidase that contains greater than 95% of the copper found in plasma...
  12. ncbi Oxidative stress in autism: increased lipid peroxidation and reduced serum levels of ceruloplasmin and transferrin--the antioxidant proteins
    Abha Chauhan
    NYS Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, New York 10314, USA
    Life Sci 75:2539-49. 2004
    ..Levels of major antioxidant proteins namely, transferrin (iron-binding protein) and ceruloplasmin (copper-binding protein) in the serum, were significantly reduced in autistic children as compared to their ..
  13. ncbi Ceruloplasmin regulates iron levels in the CNS and prevents free radical injury
    Bharatkumar N Patel
    Centre for Research in Neuroscience, The Montreal General Hospital Research Institute and McGill University, Montreal, Quebec, Canada, H3G 1A4
    J Neurosci 22:6578-86. 2002
    b>Ceruloplasmin is a ferroxidase that oxidizes toxic ferrous iron to its nontoxic ferric form. We have previously reported that a glycosylphosphatidylinositol-anchored form of ceruloplasmin is expressed in the mammalian CNS...
  14. ncbi Decreased serum ceruloplasmin levels characteristically aggravate nigral iron deposition in Parkinson's disease
    Lirong Jin
    Department of Neurology, Zhongshan Hospital and Shanghai Medical College, Fudan University, Shanghai, China
    Brain 134:50-8. 2011
    ..red nucleus and frontal white matter of 45 patients with Parkinson's disease with decreased or normal serum ceruloplasmin levels, together with age- and gender-matched control subjects...
  15. pmc A prognostic role for ceruloplasmin in the diagnosis of indolent and recurrent inflammation
    R K Natesha
    Department of Surgery, Meharry Medical College, Nashville, Tennessee
    J Natl Med Assoc 84:781-4. 1992
    b>Ceruloplasmin is increased in infections, inflammatory diseases, and neoplastic diseases and may be scarcely visible to the naked eye because it imparts a faint green color to the serum...
  16. ncbi Hepcidin treatment modulates the expression of divalent metal transporter-1, ceruloplasmin, and ferroportin-1 in the rat cerebral cortex and hippocampus
    Lin Li
    Key Laboratory of Cellular Physiology, Ministry of Education, Shanxi Medical University, Taiyuan, 030001, People s Republic of China
    Biol Trace Elem Res 143:1581-93. 2011
    ..The linkage between hepcidin (Hepc) and ferroportin-1 (FPN1), the divalent metal transporter 1 (DMT1), and ceruloplasmin (CP) in the brain is unknown...
  17. ncbi The structure of the small laccase from Streptomyces coelicolor reveals a link between laccases and nitrite reductases
    Tereza Skalova
    Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, v v i, Heyrovskeho nam 2, 162 06 Praha 6, Czech Republic
    J Mol Biol 385:1165-78. 2009
    ..Three copper ions of type 1 lie close to one another near the surface of the central part of the trimer, and, effectively, a trimeric substrate binding site is formed in their vicinity...
  18. pmc Endoplasmic reticulum quality control of unassembled iron transporter depends on Rer1p-mediated retrieval from the golgi
    Miyuki Sato
    Molecular Membrane Biology Laboratory, RIKEN Discovery Research Institute, Saitama 351 0198, Japan
    Mol Biol Cell 15:1417-24. 2004
    ..These findings provide clear evidence that the ER quality control of unassembled membrane proteins can be achieved by retrieval from the Golgi and that Rer1p serves as a specific sorting receptor in this process...
  19. ncbi Ceruloplasmin dysfunction and therapeutic potential for Parkinson disease
    Scott Ayton
    Oxidation Biology Laboratory, Florey Institute for Neuroscience and Mental Health, Parkville, Victoria, Australia
    Ann Neurol 73:554-9. 2013
    b>Ceruloplasmin is an iron-export ferroxidase that is abundant in plasma and also expressed in glia...
  20. ncbi Copper and ceruloplasmin status in serum of prostate and colon cancer patients
    Shivananda B Nayak
    Department of Biochemistry, Kasturba Medical College, Manipal 576 119
    Indian J Physiol Pharmacol 47:108-10. 2003
    Serum copper and ceruloplasmin levels were estimated in 20 patients each of prostate and colon cancer...
  21. pmc Targeted gene disruption reveals an essential role for ceruloplasmin in cellular iron efflux
    Z L Harris
    Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 96:10812-7. 1999
    ..Affected individuals evidence iron accumulation in tissue parenchyma in association with absent serum ceruloplasmin. Genetic studies of such patients reveal inherited mutations in the ceruloplasmin gene...
  22. ncbi Phase II trial of copper depletion with tetrathiomolybdate as an antiangiogenesis strategy in patients with hormone-refractory prostate cancer
    N Lynn Henry
    Department of Internal Medicine, Division of Hematology, University of Michigan School of Medicine, Ann Arbor, Mich, USA
    Oncology 71:168-75. 2006
    ..In tumor models, the copper-chelating agent tetrathiomolybdate (TM) has been shown to be antiangiogenic. We evaluated the antitumor activity of TM in patients with hormone-refractory prostate cancer (HRPC)...
  23. ncbi Biological effects of mutant ceruloplasmin on hepcidin-mediated internalization of ferroportin
    Satoshi Kono
    First Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Biochim Biophys Acta 1802:968-75. 2010
    b>Ceruloplasmin plays an essential role in cellular iron efflux by oxidizing ferrous iron exported from ferroportin. Ferroportin is posttranslationally regulated through internalization triggered by hepcidin binding...
  24. ncbi Effects of cholesterol and inflammation-sensitive plasma proteins on incidence of myocardial infarction and stroke in men
    G Engstrom
    Department of Community Medicine, Malmo University Hospital, Malmo, Sweden
    Circulation 105:2632-7. 2002
    ..This study explored whether the cholesterol-related incidence of stroke and myocardial infarction is modified by plasma markers of inflammation in a large, population-based cohort with a long follow-up...
  25. ncbi Ceruloplasmin and superoxide dismutase (SOD1) in Parkinson's disease: a follow-up study
    Gudlaug Torsdottir
    Institute of Pharmacy, Pharmacology and Toxicology, Department of Pharmacology and Toxicology, University of Iceland, Hofsvallagata 53, 107 Reykjavik, Iceland
    J Neurol Sci 241:53-8. 2006
    In this follow-up study concentration, oxidative activity and specific oxidative activity of ceruloplasmin (CP) in serum and the activity of superoxide dismutase (SOD1) in erythrocytes were reexamined in 28 of originally 40 patients with ..
  26. ncbi Screening disease-associated proteins from sera of patients with rheumatoid arthritis: a comparative proteomic study
    Tian wang Li
    Department of Rheumatology, Third Affiliated Hospital of Sun Yat Sen University, Guangzhou, Guangdong 510630, China
    Chin Med J (Engl) 123:537-43. 2010
    ..This study was performed to screen candidate RA-associated serum proteins by comparative proteomics to provide research clues to early diagnosis and treatment of RA...
  27. ncbi Case-control studies on ceruloplasmin and superoxide dismutase (SOD1) in neurodegenerative diseases: a short review
    Gudlaug Torsdottir
    Department of Pharmacology and Toxicology, University of Iceland, Iceland
    J Neurol Sci 299:51-4. 2010
    This short review describes a series of case-control studies on the concentration and oxidative activity of ceruloplasmin (CP) in serum and the activity of superoxide dismutase (SOD1) in erythrocytes in patients with Alzheimer's disease (..
  28. ncbi Role of ceruloplasmin in cellular iron uptake
    C K Mukhopadhyay
    Department of Cell Biology, The Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Science 279:714-7. 1998
    Individuals with hereditary ceruloplasmin (Cp) deficiency have profound iron accumulation in most tissues, which suggests that Cp is important for normal release of cellular iron...
  29. ncbi A multicopper ferroxidase involved in iron binding to transferrins in Dunaliella salina plasma membranes
    Yakov Paz
    Department of Biological Chemistry, The Weizmann Institute of Science, Rehovot 76100, Israel
    J Biol Chem 282:8658-66. 2007
    ..We propose that the function of D-Fox in D. salina has been modified during evolution from redox-mediated to transferrin-mediated iron uptake, following a gene transfer event of transferrins from an ancestral animal cell...
  30. ncbi Expression of ferroportin1, hephaestin and ceruloplasmin in rat heart
    Zhong Ming Qian
    Laboratory of Iron Metabolism, Department of Applied Biology and Chemical Technology and National Key Laboratory of Chinese Medicine and Molecular Pharmacology Shenzhen, Hong Kong, PR China
    Biochim Biophys Acta 1772:527-32. 2007
    ..Here, we investigated expression of iron exporters including ferroportin 1 (Fpn1), ceruloplasmin (CP) and hephaestin (Heph) and provided evidence for their existence in the heart...
  31. pmc Ceruloplasmin fragmentation is implicated in 'free' copper deregulation of Alzheimer's disease
    Rosanna Squitti
    AFaR, Department of Neuroscience, Fatebenefratelli Hospital, Isola Tiberina, Rome, Italy
    Prion 2:23-7. 2008
    ..We recently demonstrated that an excess of non-ceruloplasmin-copper (i.e...
  32. ncbi Features of ceruloplasmin in the cerebrospinal fluid of Alzheimer's disease patients
    Concetta R Capo
    Department of Biology, Tor Vergata University of Rome, Via della Ricerca Scientifica, 00133 Rome, Italy
    Biometals 21:367-72. 2008
    The level of the apo-form of the copper enzyme ceruloplasmin (CP) is an established peripheral marker in diseases associated with copper imbalance...
  33. ncbi Ceruloplasmin oxidation, a feature of Parkinson's disease CSF, inhibits ferroxidase activity and promotes cellular iron retention
    Stefano Olivieri
    Proteome Biochemistry, San Raffaele Scientific Institute, I 20132 Milan, Italy
    J Neurosci 31:18568-77. 2011
    Parkinson's disease is a neurodegenerative disorder characterized by oxidative stress and CNS iron deposition. Ceruloplasmin is an extracellular ferroxidase that regulates cellular iron loading and export, and hence protects tissues from ..
  34. ncbi Cerebrospinal fluid diagnostic markers correlate with lower plasma copper and ceruloplasmin in patients with Alzheimer's disease
    H Kessler
    Department of Psychiatry and Psychotherapy, Saarland University, Homburg Saar, Germany
    J Neural Transm 113:1763-9. 2006
    ..of these cerebrospinal fluid (CSF) diagnostic markers with primary dependent variables blood Cu, Zn and ceruloplasmin (CB) and secondary with CSF profiles of Cu, Zn and neurotransmitters was determined...
  35. ncbi Frameshift and nonsense mutations in the gene for ATPase7B are associated with severe impairment of copper metabolism and with an early clinical manifestation of Wilson's disease
    G Gromadzka
    Institute of Psychiatry and Neurology, Second Department of Neurology, Warsaw, Poland
    Clin Genet 68:524-32. 2005
    ..Patients with one or two SMs on their alleles had lower serum copper and ceruloplasmin and were younger when the first symptoms of the disease appeared, compared with individuals with two MMs...
  36. pmc Disruption of ceruloplasmin and hephaestin in mice causes retinal iron overload and retinal degeneration with features of age-related macular degeneration
    Paul Hahn
    The F M Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 101:13850-5. 2004
    ..To determine whether the ferroxidase ceruloplasmin (Cp) and its homolog hephaestin (Heph) are important for retinal iron homeostasis, we studied retinas from ..
  37. ncbi Ceruloplasmin gene variations and substantia nigra hyperechogenicity in Parkinson disease
    H Hochstrasser
    Institute for Medical Genetics, University of Tuebingen, Germany
    Neurology 63:1912-7. 2004
    ..However, sequence variations in genes involved in iron metabolism have been linked to basal ganglia disorders. One of these is ceruloplasmin (Cp), which is vitally involved in iron transport across the cell membrane.
  38. ncbi Copper-dependent activation of hypoxia-inducible factor (HIF)-1: implications for ceruloplasmin regulation
    Falk Martin
    Carl Ludwig Institute of Physiology, University of Leipzig, Germany
    Blood 105:4613-9. 2005
    ..b>Ceruloplasmin, the main copper transport protein in the plasma and a known HIF-1 target in vitro, was also induced in vivo ..
  39. ncbi Role of hypoxia-inducible factor-1 in transcriptional activation of ceruloplasmin by iron deficiency
    C K Mukhopadhyay
    Department of Cell Biology, The Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Biol Chem 275:21048-54. 2000
    A role of the copper protein ceruloplasmin (Cp) in iron metabolism is suggested by its ferroxidase activity and by the tissue iron overload in hereditary Cp deficiency patients...
  40. ncbi Lipid peroxidation, some extracellular antioxidants, and antioxidant enzymes in serum of patients with rheumatoid arthritis
    S Taysi
    Department of Biochemistry, Faculty of Medicine, Ataturk University, Erzurum, Turkey
    Rheumatol Int 21:200-4. 2002
    ..Serum malondialdehyde and ceruloplasmin levels and the activity of CuZn superoxide dismutase were higher, while transferrin levels and the activities ..
  41. ncbi Ceruloplasmin and what it might do
    J Healy
    Department of Biochemistry, School of Biochemistry and Immunology, Trinity College, Dublin, Ireland
    J Neural Transm 114:777-81. 2007
    The blue coloured plasma protein ceruloplasmin binds up to 95% of circulating copper, and has several possible functions...
  42. ncbi Lower serum ceruloplasmin levels correlate with younger age of onset in Parkinson's disease
    Kersi J Bharucha
    Department of Neurology, University of Oklahoma Health Sciences, Center and Veterans Administration, Medical Center, 711 Stanton L Young Blvd, Oklahoma City, OK 73104, USA
    J Neurol 255:1957-62. 2008
    b>Ceruloplasmin functions as a ferroxidase in iron metabolism. Parkinson's disease (PD) is characterized by an increase in brain iron...
  43. ncbi The regulation of cellular iron metabolism
    Anita C G Chua
    School of Medicine and Pharmacology, University of Western Australia, Fremantle, Western Australia, Australia
    Crit Rev Clin Lab Sci 44:413-59. 2007
    ..Current knowledge on their roles in maintaining iron homeostasis and how their dysregulation leads to the pathogenesis of HH are discussed...
  44. ncbi Levels of ceruloplasmin, transferrin, and lipid peroxidation in the serum of patients with Type 2 diabetes mellitus
    Ramazan Memisogullari
    Department of Biochemistry, Medical School, Ataturk University, Erzurum 25240, Turkey
    J Diabetes Complications 18:193-7. 2004
    ..Increased oxidant stress has been implicated in the pathogenesis of DM. An increase in serum ceruloplasmin (Cp) levels has also been reported in Type 2 DM. Cp permits the incorporation of iron into transferrin (Trf)...
  45. ncbi Analysis of the human hephaestin gene and protein: comparative modelling of the N-terminus ecto-domain based upon ceruloplasmin
    Basharut A Syed
    Department of Biochemistry and Molecular Biology, Royal Free and University College Medical School, London NW3 2PF, UK
    Protein Eng 15:205-14. 2002
    ..It is a member of the family of copper oxidases that includes mammalian ceruloplasmin, factors V and VIII, yeast fet3 and fet5 and bacterial ascorbate oxidase...
  46. ncbi Parallel increase in urinary excretion rates of immunoglobulin G, ceruloplasmin, transferrin, and orosomucoid in normoalbuminuric type 2 diabetic patients
    Takuma Narita
    Department of Endocrinology, Diabetes and Geriatric Medicine, Akita University School of Medicine, Akita, Japan
    Diabetes Care 27:1176-81. 2004
    ..plasma proteins with different molecular radii <55 A and different isoelectric points (pI), such as IgG, ceruloplasmin, transferrin, and orosomucoid, have been independently reported to precede the development of microalbuminuria ..
  47. pmc The Menkes/Wilson disease gene homologue in yeast provides copper to a ceruloplasmin-like oxidase required for iron uptake
    D S Yuan
    Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 92:2632-6. 1995
    ..A biochemical hallmark of these diseases is a deficiency of copper in ceruloplasmin and other copper proteins found in extracytosolic compartments...
  48. ncbi Congestive heart failure in copper-deficient mice
    Laila Elsherif
    Department of Pharmacology and Toxicology, University of Louisville, Louisville, Kentucky 40202, USA
    Exp Biol Med (Maywood) 228:811-7. 2003
    ..This study shows that CuD leads to systolic and diastolic dysfunction in association with histopathological changes, which are indices commonly used to diagnose congestive heart failure...
  49. pmc Serum ceruloplasmin levels correlate negatively with liver fibrosis in males with chronic hepatitis B: a new noninvasive model for predicting liver fibrosis in HBV-related liver disease
    Da Wu Zeng
    Liver Center, First Affiliated Hospital, Fujian Medical University, Taijiang District, Fuzhou, Fujian Province, China
    PLoS ONE 8:e77942. 2013
    This study aimed to investigate associations between ceruloplasmin (CP) levels, inflammation grade and fibrosis stages in patients with chronic hepatitis B (CHB) and to establish a noninvasive model to predict cirrhosis.
  50. ncbi Sustained increases of plasma homocysteine, copper, and serum ceruloplasmin after coronary artery bypass grafting
    Jamie Y Jeremy
    Bristol Heart Institute, Bristol Royal Infirmary, United Kingdom
    Ann Thorac Surg 74:1553-7. 2002
    ..The aim of this study was to assess the perioperative levels of Hcy, copper, ceruloplasmin (CP), folate, and vitamin B12 in patients undergoing myocardial revascularization surgery.
  51. ncbi Genotype-phenotype correlation in Italian children with Wilson's disease
    Emanuele Nicastro
    Department of Pediatrics, University of Naples Federico II, Naples, Italy
    J Hepatol 50:555-61. 2009
    ..Wilson's disease phenotype is very variable for clinical and laboratory features. Our aim was to assess the role of the type of ATP7B disease causing mutations on Wilson's disease phenotype...
  52. ncbi Plasma ceruloplasmin ferroxidase activity correlates with the nigral sonographic area in Parkinson's disease patients: a pilot study
    Rubén Martínez-Hernández
    Department of Neurology, National Institute of Neurology and Neurosurgery, Mexico City, Mexico
    Neurochem Res 36:2111-5. 2011
    ..001). Interestingly, plasma ferroxidase activity was inversely correlated with the SN size by TCS (R² = 0.31), suggesting a relationship between the two markers...
  53. ncbi Antioxidant potential, paraoxonase 1, ceruloplasmin activity and C-reactive protein concentration in diabetic retinopathy
    Mariusz Nowak
    Department of Pathophysiology and Endocrinology, Medical University of Silesia, Poland
    Clin Exp Med 10:185-92. 2010
    The aim of this study was to evaluate the ferric-reducing ability of serum (FRAS), paraoxonase 1 (PON1), ceruloplasmin serum oxidase activity and hsCRP level in patients with type1 diabetes mellitus without and with diabetic retinopathy...
  54. ncbi Ceruloplasmin and cardiovascular disease
    P L Fox
    Department of Cell Biology, The Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Free Radic Biol Med 28:1735-44. 2000
    ..We and others have investigated the role of human ceruloplasmin (Cp) in oxidative processes because it the principal copper-containing protein in serum...
  55. ncbi Ceruloplasmin and myeloperoxidase in complex affect the enzymatic properties of each other
    Alexej V Sokolov
    Department of Molecular Genetics of the Institute for Experimental Medicine of the Russian Academy of Medical Sciences, Saint Petersburg, Russia
    Free Radic Res 42:989-98. 2008
    b>Ceruloplasmin (CP), the multicopper oxidase of plasma, interacts with myeloperoxidase (MPO), an enzyme of leukocytes, and inhibits its peroxidase and chlorinating activity...
  56. ncbi Ceruloplasmin is a better predictor of the long-term prognosis compared with fibrinogen, CRP, and IL-6 in patients with severe unstable angina
    Antonios Ziakas
    1st Cardiology Department, AHEPA, University Hospital, Thessaloniki, Greece
    Angiology 60:50-9. 2009
    We investigated the time course and prognostic value of fibrinogen (Fib), C-reactive protein (CRP), interleukin-6 (IL-6), and ceruloplasmin (CP) in patients with severe unstable angina.
  57. ncbi Lactoferrin and ceruloplasmin derivatized superparamagnetic iron oxide nanoparticles for targeting cell surface receptors
    Ajay Kumar Gupta
    Centre for Cell Engineering, Institute of Biomedical and Life Sciences, Joseph Black Building, University of Glasgow, Glasgow G12 8QQ, Scotland, United Kingdom
    Biomaterials 25:3029-40. 2004
    ..In contradiction, lactoferrin or ceruloplasmin coated nanoparticles attached to the cell membrane, most likely to the cell expressed receptors and were not ..
  58. ncbi Placental ceruloplasmin homolog is regulated by iron and copper and is implicated in iron metabolism
    Ruth Danzeisen
    The Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, United Kingdom
    Am J Physiol Cell Physiol 282:C472-8. 2002
    We previously reported an endogenous, membrane-bound Cu oxidase with homology to ceruloplasmin in BeWo cells, a placental choriocarcinoma cell line...
  59. ncbi Evidence for a critical role of ceruloplasmin oxidase activity in iron metabolism of Wilson disease gene knockout mice
    Uta Merle
    Department of Gastroenterology, University Hospital, Heidelberg, Germany
    J Gastroenterol Hepatol 25:1144-50. 2010
    ..Therefore, the present study was carried out to elucidate iron metabolism in Atp7b(-/-) mice, an animal model of Wilson disease...
  60. ncbi In vitro interaction between ceruloplasmin and human serum transferrin
    Nguyêt Thanh Ha-Duong
    Laboratoire ITODYS Interfaces, Traitements et Organisation des Systèmes, Université Paris Diderot, CNRS UMR 7086, Bâtiment Lavoisier, 15 rue Jean Antoine de Baïf, Paris Cedex 13, France
    Biochemistry 49:10261-3. 2010
    The thermodynamics of the interactions of serum apotransferrin (T) and holotransferrin (TFe(2)) with ceruloplasmin (Cp), as well as those of human lactoferrin (Lf), were assessed by fluorescence emission spectroscopy...
  61. ncbi Systemic levels of ceruloplasmin oxidase activity in allergic asthma and allergic rhinitis
    Arzu Didem Yalcin
    Internal Medicine, Allergy and Clinical Immunology Unit, Antalya Education and Research Hospital, Antalya, Turkey
    Immunopharmacol Immunotoxicol 34:1047-53. 2012
    The role of ceruloplasmin oxidase activity (COA) involving the interaction of oxidant and antioxidant balance in allergic diseases is still unknown.
  62. pmc A new role for heme, facilitating release of iron from the bacterioferritin iron biomineral
    Samina Yasmin
    Centre for Molecular and Structural Biochemistry, School of Chemistry, University of East Anglia, Norwich NR4 7TJ, United Kingdom
    J Biol Chem 286:3473-83. 2011
    ..Finally, we show that the catalytic ferroxidase center, which is central to the mechanism of mineralization, is not involved in iron release; thus, core mineralization and release processes utilize distinct pathways...
  63. pmc Serum ceruloplasmin protein expression and activity increases in iron-deficient rats and is further enhanced by higher dietary copper intake
    Perungavur N Ranganathan
    Department of Food Science and Human Nutrition, University of Florida, Gainesville, FL, USA
    Blood 118:3146-53. 2011
    ..One point of intersection between the 2 metals is the liver-derived, multicopper ferroxidase ceruloplasmin (Cp) that is important for iron release from certain tissues...
  64. pmc Multicopper oxidase-1 is a ferroxidase essential for iron homeostasis in Drosophila melanogaster
    Minglin Lang
    Department of Biochemistry, Kansas State University, Manhattan, KS 66506, USA
    Proc Natl Acad Sci U S A 109:13337-42. 2012
    ..Given that MCO1 orthologues are present in all insect genomes analyzed to date, this discovery is an important step toward understanding iron metabolism in insects...
  65. ncbi The ceruloplasmin homolog hephaestin and the control of intestinal iron absorption
    Gregory J Anderson
    Iron Metabolism Laboratory, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane, Queensland 4029, Australia
    Blood Cells Mol Dis 29:367-75. 2002
    ..Hephaestin is homologous to the plasma copper-containing protein ceruloplasmin, and all residues involved in copper binding and disulfide bond formation in ceruloplasmin are conserved in ..
  66. ncbi The activity of cholesterol esterase and ceruloplasmin are inversely related in the serum of men with atherosclerosis obliterans
    M Piorunska-Stolzmann
    Department of General Chemistry, Chair and Department of Clinical Biochemistry, Medical University, Poznan, Poland
    Med Sci Monit 7:940-5. 2001
    b>Ceruloplasmin is a copper-containing (2-glycoprotein and a member of the acute phase reactant family...
  67. ncbi The effects of nitric oxide-oxidase and putative glutathione-peroxidase activities of ceruloplasmin on the viability of cardiomyocytes exposed to hydrogen peroxide
    Mylène Paradis
    Département de Chimie et de biochimie and Centre Biomed, Universite du Quebec a Montreal, Montreal, QC, Canada
    Free Radic Biol Med 49:2019-27. 2010
    b>Ceruloplasmin (CP), a ferroxidase (EC 1.16.3.1) and a scavenger of reactive oxygen species, is an important extracellular antioxidant. Bovine CP indeed protects the isolated heart under ischemia-reperfusion conditions...
  68. ncbi Comparison of the three-dimensional structures of recombinant human H and horse L ferritins at high resolution
    P D Hempstead
    Krebs Institute for Biomolecular Research, Department of Molecular Biology and Biotechnology, University of Sheffield, England
    J Mol Biol 268:424-48. 1997
    ..L chains contain a group of glutamates associated with mineralisation within the iron storage cavity of the protein...
  69. ncbi Quantitative evaluation of expression of iron-metabolism genes in ceruloplasmin-deficient mice
    Kanji Yamamoto
    The Third Department of Medicine, Shinshu University School of Medicine, Matsumoto 390 8621, Japan
    Biochim Biophys Acta 1588:195-202. 2002
    Aceruloplasminemia is an autosomal recessive disorder caused by mutations in the ceruloplasmin (CP) gene, and is characterized by a unique combination of neurovisceral iron overload and iron deficiency anemia...
  70. pmc Crystal structure of Bfr A from Mycobacterium tuberculosis: incorporation of selenomethionine results in cleavage and demetallation of haem
    Vibha Gupta
    Department of Biochemistry, University of Delhi South Campus, New Delhi, India
    PLoS ONE 4:e8028. 2009
    ..In addition, this study provides evidence against the general belief that a selenium derivative of a protein represents its true physiological native structure...
  71. pmc Isolation and partial nucleotide sequence of the laccase gene from Neurospora crassa: amino acid sequence homology of the protein to human ceruloplasmin
    U A Germann
    Proc Natl Acad Sci U S A 83:8854-8. 1986
    ..striking sequence homology to the carboxyl-terminal part of the third homology unit of the multicopper oxidase ceruloplasmin and to a smaller extent, to the low molecular weight blue copper proteins plastocyanin and azurin...
  72. ncbi A critical overview of the chemistry of copper-dependent low density lipoprotein oxidation: roles of lipid hydroperoxides, alpha-tocopherol, thiols, and ceruloplasmin
    M J Burkitt
    Gray Cancer Institute, Mount Vernon Hospital, Northwood, Middlesex, HA6 2JR, United Kingdom
    Arch Biochem Biophys 394:117-35. 2001
    ..Finally, the mechanisms by which ceruloplasmin, a copper-containing plasma protein, can bring about LDL modification are discussed...
  73. ncbi Increased vulnerability to rotenone-induced neurotoxicity in ceruloplasmin-deficient mice
    Kazuma Kaneko
    Department of Neurology and Rheumatology, Shinshu University School of Medicine, 3 1 1 Asahi, 390 8621 Matsumoto, Japan
    Neurosci Lett 446:56-8. 2008
    b>Ceruloplasmin (Cp) is the strongest ferroxidase in human plasma...
  74. ncbi Proteomic analysis of amniotic fluid in pregnancies with Klinefelter syndrome foetuses
    Athanasios K Anagnostopoulos
    Medical Genetics, Athens University School of Medicine, Athens, Greece
    J Proteomics 73:943-50. 2010
    ..Samples were analysed by 2-DE, coupled with MALDI-TOF-MS analysis. Three proteins (Ceruloplasmin, Alpha-1-antitrypsin and Zinc-alpha-2-glycoprotein) were found to be up-regulated in samples obtained from ..
  75. ncbi Glycosylphosphatidylinositol-anchored ceruloplasmin is required for iron efflux from cells in the central nervous system
    Suh Young Jeong
    Centre for Research in Neuroscience, McGill University Health Centre, Montreal General Hospital Research Institute, Montreal, Quebec H3G 1A4, Canada
    J Biol Chem 278:27144-8. 2003
    b>Ceruloplasmin (Cp) is a ferroxidase that converts highly toxic ferrous iron to its non-toxic ferric form...
  76. ncbi The neurological presentation of ceruloplasmin gene mutations
    Alisdair McNeill
    Department of Clinical Genetics, NIHR, Birmingham Women s Hospital, Birmingham, UK
    Eur Neurol 60:200-5. 2008
    Aceruloplasminemia is an autosomal recessive disorder of iron metabolism resulting from mutations of the ceruloplasmin gene...
  77. ncbi A mutation in the ceruloplasmin gene is associated with systemic hemosiderosis in humans
    K Yoshida
    Department of Medicine Neurology, Shinshu University School of Medicine, Matsumoto, Japan
    Nat Genet 9:267-72. 1995
    We identified a mutation in the ceruloplasmin (Cp) gene in a Japanese family with aceruloplasminemia, some of whose members showed extrapyramidal disorders, cerebellar ataxia, and diabetes mellitus...
  78. pmc Binding and inhibition of myeloperoxidase (MPO): a major function of ceruloplasmin?
    M Segelmark
    Department of Nephrology, Lund University, University Hospital, Sweden
    Clin Exp Immunol 108:167-74. 1997
    ..wt of 130 kD showed affinity for MPO. The protein was identified as ceruloplasmin by N-terminal amino acid sequencing and immunochemistry...
  79. ncbi Patterns of correlation of plasma ceruloplasmin in sepsis
    Carlo Chiarla
    IASI CNR Center for Pathophysiology of Shock, Catholic University School of Medicine, Rome, Italy
    J Surg Res 144:107-10. 2008
    In sepsis, plasma ceruloplasmin (Cp, mg/L) is known to increase as part of the acute phase response...
  80. ncbi Interleukin-1β induces ceruloplasmin and ferroportin-1 gene expression via MAP kinases and C/EBPβ, AP-1, and NF-κB activation
    Tiziana Persichini
    Department Biology, Universita Roma Tre, 00146 Rome, Italy
    Neurosci Lett 484:133-8. 2010
    ..able to increase iron efflux from glial cells through a coordinate induction of both ferroportin-1 (Fpn) and ceruloplasmin (Cp) synthesis...
  81. pmc Aceruloplasminemia: molecular characterization of this disorder of iron metabolism
    Z L Harris
    Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 92:2539-43. 1995
    b>Ceruloplasmin is an abundant alpha 2-serum glycoprotein that contains 95% of the copper found in the plasma of vertebrate species...
  82. ncbi Novel types of two-domain multi-copper oxidases: possible missing links in the evolution
    Kensuke Nakamura
    Graduate School of Information Science, Nara Institute of Science and Technology, 8916 5 Takayama cho, Ikoma, 630 0101 Nara, Japan
    FEBS Lett 553:239-44. 2003
    ..conspicuous combination of blue-copper and inter-domain trinuclear copper binding residues, which is common in ceruloplasmin and ascorbate oxidase but not in nitrite reductase, and therefore are considered to retain the characteristics ..
  83. pmc The copper-iron connection in biology: structure of the metallo-oxidase Fet3p
    Alexander B Taylor
    Department of Biochemistry and the X ray Crystallography Core Laboratory, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Proc Natl Acad Sci U S A 102:15459-64. 2005
    ..The mammalian ferroxidases ceruloplasmin and hephaestin are homologs of Fet3p...
  84. ncbi Oxidase activity of ceruloplasmin and concentrations of copper and zinc in serum of cancer patients
    M Zowczak
    Karol Marcinkowski University of Medical Sciences, Poznan, Poland
    J Trace Elem Med Biol 15:193-6. 2001
    ..b>Ceruloplasmin (Cp) carries up to 90% of Cu in plasma and performs ferroxidase, antioxidant and amine oxidase activity...
  85. ncbi Iron overload and antioxidative role of perivascular astrocytes in aceruloplasminemia
    T Oide
    Department of Laboratory Medicine, Musashi Hospital, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan
    Neuropathol Appl Neurobiol 32:170-6. 2006
    Aceruloplasminemia (ACP) is an inherited disorder of iron metabolism caused by the lack of ceruloplasmin activity; the neuropathological hallmarks are excessive iron deposition, neuronal loss, bizarrely deformed astrocytes, and numerous '..
  86. ncbi Ceruloplasmin in neurodegenerative diseases
    Vadim Vassiliev
    Institute for Experimental Medicine, St Petersburg, Russia
    Brain Res Brain Res Rev 49:633-40. 2005
    For decades, abnormalities in ceruloplasmin (Cp) synthesis have been associated with neurodegenerative disease...
  87. ncbi Diagnosis of Wilson's disease: a comprehensive review
    Chloe M Mak
    Department of Chemical Pathology, The Chinese University of Hong Kong, Hong Kong SAR, China
    Crit Rev Clin Lab Sci 45:263-90. 2008
    ..high clinical suspicion, typical neurological symptoms, presence of Kayser-Fleischer rings, and reduced serum ceruloplasmin concentration. The conventional value of < 0.20 g/l is not a universal diagnostic value...
  88. pmc Plasma peptidylglycine alpha-amidating monooxygenase (PAM) and ceruloplasmin are affected by age and copper status in rats and mice
    Joseph R Prohaska
    Department of Biochemistry and Molecular Biology, University of Minnesota Medical School Duluth, 1035 University Drive, 55812, USA
    Comp Biochem Physiol B Biochem Mol Biol 143:360-6. 2006
    ..alpha-amidating monooxygenase (PAM ), an enzyme involved in peptide posttranslational activation, to ceruloplasmin (Cp), a ferroxidase involved in iron mobilization...
  89. ncbi Copper, ceruloplasmin and superoxide dismutase (SOD1) in patients with Down's syndrome
    G Torsdottir
    Department of Pharmacology and Toxicology, The Institute of Pharmacy, Pharmacology and Toxicology, University of Iceland, P O Box 8216, 128 Reykjavik, Iceland
    Pharmacol Toxicol 89:320-5. 2001
    ..Copper was accordingly determined in plasma, ceruloplasmin concentration in serum, ceruloplasmin oxidative activity and ceruloplasmin specific oxidative activity (..
  90. ncbi Structural characterization of the ceruloplasmin: lactoferrin complex in solution
    Annalaura Sabatucci
    Department of Biomedical Sciences, University of Teramo, Teramo, Italy
    J Mol Biol 371:1038-46. 2007
    b>Ceruloplasmin is a copper protein found in vertebrate plasma, which belongs to the family of multicopper oxidases...
  91. pmc Structural studies of bacterioferritin B from Pseudomonas aeruginosa suggest a gating mechanism for iron uptake via the ferroxidase center
    Saroja K Weeratunga
    Ralph N Adams Institute for Bioanalytical Chemistry and Department of Chemistry, University of Kansas, Multidisciplinary Research Building, 2030 Becker Drive, Room 220 E, Lawrence, Kansas 66047, USA
    Biochemistry 49:1160-75. 2010
    ..C., Lawson, T. L., Lewin, A., Moore, G. R., and Le Brun, N. E. (2009) J. Am. Chem. Soc. 131, 6808-6813], indicate that not all bacterioferritins operate in the same manner...
  92. ncbi Increased urinary excretions of immunoglobulin g, ceruloplasmin, and transferrin predict development of microalbuminuria in patients with type 2 diabetes
    Takuma Narita
    The Department of Endocrinology, Diabetes, and Geriatric Medicine, Akita University School of Medicine, Hondo, Akita 010 8543, Japan
    Diabetes Care 29:142-4. 2006
  93. ncbi Serum level and antioxidant activity of ceruloplasmin in preeclampsia
    L Shakour-Shahabi
    Obstetrics and Gynecology Ward, Tabriz University of Medical Sciences, Tabriz, Iran
    Pak J Biol Sci 13:621-7. 2010
    ..This study was aimed to determine the serum level and antioxidant activity of ceruloplasmin in preeclamptic women with gestational age over than 28 weeks...
  94. ncbi Effects of development and iron status on ceruloplasmin expression in rat brain
    Yan Zhong Chang
    Laboratory of Brain Iron Metabolism, Department of Applied Biology and Chemical Technology, Hong Kong Polytechnic University, Kowloon, Hong Kong
    J Cell Physiol 204:623-31. 2005
    The increased iron content in the brain of subjects with aceruloplasminemia has implicated ceruloplasmin (CP) as a major factor in the regulation of regional brain iron content...
  95. pmc Ceruloplasmin gene expression in the murine central nervous system
    L W Klomp
    Edward Mallinckrodt Department off Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 98:207-15. 1996
    ..of central nervous system iron accumulation and neuronal loss in this disease, cDNA clones encoding murine ceruloplasmin were isolated and characterized. RNA blot analysis using these clones detected a 3...
  96. pmc Crystal structure of the ferritin from the hyperthermophilic archaeal anaerobe Pyrococcus furiosus
    Jana Tatur
    Department of Biotechnology, Delft University of Technology, Julianalaan 67, 2628 BC Delft, The Netherlands
    J Biol Inorg Chem 12:615-30. 2007
    ..A preservation of the monomer fold, rather than the 24-mer assembly, appears to be the most important factor that protects the ferritin from inactivation by heat...
  97. ncbi Copper regulated synthesis, secretion and degradation of ceruloplasmin in a mouse immortalized hepatocytic cell line
    P Pisu
    Istituto Nazionale di Ricerca per gli Alimenti e la Nutrizione INRAN, Via Ardeatina 546, 00178 Rome, Italy
    Cell Mol Biol (Noisy-le-grand) . 2005
    b>Ceruloplasmin, a blue copper oxidase circulating in serum of all vertebrates, is a glycoprotein synthesized mainly in hepatocytes and secreted into plasma with six tightly bound atoms of copper per molecule...
  98. pmc Ceruloplasmin and the extent of heart failure in ischemic and nonischemic cardiomyopathy patients
    Yifei Xu
    Department of Cardiology, Second Affiliated Hospital, Zhejiang University, College of Medicine, Hangzhou, Zhejiang 310009, China
    Mediators Inflamm 2013:348145. 2013
    b>Ceruloplasmin was elevated in patients with coronary heart disease, but the relationship between ceruloplasmin and heart failure was still unknown...
  99. pmc Ceruloplasmin protects against rotenone-induced oxidative stress and neurotoxicity
    Akiyo Hineno
    Department of Medicine Neurology and Rheumatology, Shinshu University School of Medicine, Matsumoto 390 8621, Japan
    Neurochem Res 36:2127-35. 2011
    To clarify the neuroprotective property of ceruloplasmin and the pathogenesis of aceruloplasminemia, we generated ceruloplasmin-deficient (CP⁻/⁻) mice on the C57BL/10 genetic background and further treated them with a mitochondrial ..
  100. ncbi Ferrous binding to the multicopper oxidases Saccharomyces cerevisiae Fet3p and human ceruloplasmin: contributions to ferroxidase activity
    Liliana Quintanar
    Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
    J Am Chem Soc 126:6579-89. 2004
    ..Saccharomyces cerevisiae Fet3p and human ceruloplasmin (hCp) are members of this family that exhibit ferroxidase activity...
  101. ncbi Hepatic iron overload associated with a decreased serum ceruloplasmin level in a novel clinical type of aceruloplasminemia
    Satoshi Kono
    The First Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Gastroenterology 131:240-5. 2006
    Aceruloplasminemia is a novel hereditary iron overload disease caused by a mutation in the ceruloplasmin gene and characterized by a complete deficiency of serum ceruloplasmin and iron accumulation in the liver and brain.

Research Grants62

  1. Molecular Mechanisms of Intestinal Metal Ion Transport During Iron Deficiency
    James F Collins; Fiscal Year: 2013
    ..Another, circulating FOX, ceruloplasmin (Cp), may also participate in Fe export from IECs...
  2. Cisplatin Resistance mediated by copper export pathways
    Stephen B Howell; Fiscal Year: 2013
    ..chloride channel ClC-4 that binds to ATP7B and is known to regulate vesicle pH and the loading of Cu onto ceruloplasmin by ATP7B, and dynactin that links vesicles to the motor protein dynein and microtubules and whose p62 subunit ..
  3. Towards Measures of Lupus Nephritis Activity &Damage for Children
    Hermine I Brunner; Fiscal Year: 2012
    ..e. neutrophil gelatinase associated lipocalin, transferrin, ceruloplasmin, al-acid glycoprotein, chemokine ligand 2, adiponectin, hepcidin, liver-type fatty acid binding protein, and ..
  4. Copper Uptake from Plasma Ceruloplasmin
    Maria C Linder; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Ceruloplasmin (Cp) is the main Cu-containing protein in the blood plasma and some other body fluids. A GPI- linked form is tethered to the surface of some cells...
  5. Spectroscopic Studies of Active Sites in Copper Proteins
    Edward I Solomon; Fiscal Year: 2011
    ..intramolecular electron transfer and its interaction with metal ion substrates relevant to iron metabolism in ceruloplasmin and its genetic disorder aceruloplasminemia, Fe uptake in yeast (Fet3p) and microbial Mn and Cu oxidation;3) ..
  6. Removing copper for pennies: an affordable strategy for Alzheimer's
    Joseph F Quinn; Fiscal Year: 2011
    ..Copper removal will be titrated by monitoring of plasma ceruloplasmin. At the end of the treatment period, spatial memory will be assessed by Morris Water Maze and brains then ..
  7. Retinal iron transport in health and disease
    Joshua L Dunaief; Fiscal Year: 2013
    ..3) Consistent with this hypothesis, in the inherited disease aceruloplasminemia, loss of the ferroxidase ceruloplasmin (Cp) results in retinal iron accumulation and early onset macular degeneration...
  8. Hephaestin's role in retinal iron homeostasis and retinal health
    Natalie Wolkow; Fiscal Year: 2012
    ..Light microscope autoradiography will be used. Systemic mutation of Hp and its homologue, Ceruloplasmin in Cp/sla mice, causes retinal iron accumulation and retinal degeneration in mice...
  9. Translational Silencing in Monocytes: Role of L13a
    Barsanjit Mazumder; Fiscal Year: 2013
    ..We have demonstrated that IFN-3 induced synthesis of Ceruloplasmin (Cp) and a group of other inflammatory proteins in monocytic cells is under translational control...
  10. Study of copper oxidoreductases through metalloprotein engineering
    Steven M Berry; Fiscal Year: 2012
    ..Common roles of copper in these proteins are electron transfer, such as in ceruloplasmin (CP) or cytochrome c oxidase (CcO), and reactivity with O2, such as in peptidyl ?-hydroxylating monooxygenase (..
  11. Role of Brain Ferroxidases in AD and sCJD Pathogenesis
    Neena Singh; Fiscal Year: 2013
    ..In an independent set of studies, the Mukhopadhayay laboratory reported that ceruloplasmin (Cp), a major ferroxidase in the brain, is down regulated by reactive oxygen species (ROS)...
  12. BIOLOGICAL METAL CLUSTERS--BIOPHYSICAL AND MODEL STUDIES
    Michael Maroney; Fiscal Year: 1999
    ..g. hemocyanin, tyrosinase, ceruloplasmin, CuA in cytochrome oxidase), Mn atoms (e.g...
  13. Hypoxia and PMN Function in Periodontitis
    IBRAHIM ALPDOGAN KANTARCI; Fiscal Year: 2012
    ..Iron is essential for regulation of O2- generation and iron metabolism is regulated by ceruloplasmin (CP), which is one of the target genes for hypoxia inducible factor-1a (HIF-1a)...
  14. METALS/NUCLEOSIDE HYDROPEROXIDE MEDIATED GENETIC DAMAGE
    Krystyna Frenkel; Fiscal Year: 1992
    ..The effects of copper and iron ions (either free or in ferritin, transferrin and ceruloplasmin) and of horseradish and glutathione peroxidases on 5-hydroperoxymethyl-2"-deoxyuridine (HPMdU)-induced ..
  15. BIOSYNTHETIC ACTIVITY OF THE CHOROID PLEXUS
    Joseph Herbert; Fiscal Year: 1993
    ..The presence of mRNA for transferrin, ceruloplasmin and the beta-preamylod protein have been reported, and we have shown, by immunohistochemistry, the presence of ..
  16. Membrane Rafts and Sertoli-Germ Cell Interactions
    SALLY NYQUIST; Fiscal Year: 2002
    ..propose to re-examine iron transport, both influx and efflux, in the presence and absence of the GPI-anchored ceruloplasmin that has been demonstrated to be a major protein in Sertoli cell DIG fractions...
  17. HEPATIC BIOSYNTHESIS OF CERULOPLASMIN
    Michael Schilsky; Fiscal Year: 1993
    ..processes involved in the biosynthetic incorporation of copper by hepatocytes into the secretory glycoprotein, ceruloplasmin. The intracellular site of copper incorporation will be determined by identification of the earliest stage of ..
  18. ORAL CONTRACEPTIVES: EFFECT ON VITAMIN C METABOLISM
    K Lei; Fiscal Year: 1980
    ..In vitro studies will be performed to measure the degradation rate of ascorbic acid by plasma ceruloplasmin ascorbic acid oxidase and by plasma copper...
  19. Intestinal Iron Transport in Iron Deficiency/Anemia
    James Collins; Fiscal Year: 2005
    ..of the basolateral membrane-specific copper ATPase (Atp7a), and 2-5-fold increases in a membrane bound form of ceruloplasmin, a multi-copper ferroxidase, which was seen in adult rats...
  20. Serum Proteins Influencing Helicobacter pylori Growth
    TRACI TESTERMAN; Fiscal Year: 2007
    ..pylori growth. Our preliminary data indicate that ceruloplasmin (cp) from human or bovine serum and at least one other unidentified serum protein are responsible for ..
  21. ASCORBATE COPPER LINK IN NUTRITION
    Edward Harris; Fiscal Year: 1991
    ..L-dihydroascobate, the vitamin, is capable under conditions permitted by host cells to mobilize cooper from ceruloplasmin, the major serum copper protein...
  22. IRON LOADING INTO FERRITIN
    STEVEN AUST; Fiscal Year: 1999
    ..Our hypothesis is that loading is accomplished by ceruloplasmin in a process that protects ferritin from oxidation by iron...
  23. NET SYNTHESIS OF PLASMA PROTEINS BY PERFUSED LIVER
    LEON MILLER; Fiscal Year: 1980
    ..Kawasaki), alpha2 (Acute phase) globulin, haptoglobin, C3 component of complement, hemopexin, and ceruloplasmin. In addition, synthesis of albumin, alpha2 U-globulin, alpha1-macroglobulin will be measured in the same ..
  24. EPR STUDIES ON DETECTION AND TREATMENT OF CANCER
    JOHN ZIMBRICK; Fiscal Year: 1980
    ..A double-blind study will be continued on the EPR signal intensity of Cu plus 2 bound to ceruloplasmin (Cu plus 2-CP) and on the ration Cu plus 2/total Cu in serum samples from female volunteers who are ..
  25. DEVELOPMENTAL REGULATION OF FETAL ANTIOXIDANT EXPRESSION
    Jonathan Gitlin; Fiscal Year: 2001
    ..The specific aims of this proposal are to define the cellular and molecular determinants of pulmonary ceruloplasmin gene expression...
  26. Targeting FKBP52 and Copper in Alzheimer's Disease
    Raymond Birge; Fiscal Year: 2007
    ..by extracellular copper, and increases in the concentration of copper and the copper transport protein ceruloplasmin are found in the CSF of AD patients...
  27. Analysis of ATP7B in Screening for Wilson Disease
    Steven Dobrowolski; Fiscal Year: 2004
    ..A recently developed ELISA assay using specific monoclonal antibody to ceruloplasmin has generated evidence that it provides the basis of a population screening assay for WD...
  28. GENETIC CONTROL OF THE STRUCTURE OF HUMAN PROTEINS
    Barbara Bowman; Fiscal Year: 1980
    ..Biochemical characterization of other serum proteins is also proposed namely, Gc, ceruloplasmin, alpha-antitrypsin, and retinal-transporting protein...
  29. DELIVERY OF COPPER TO CELLS BY SERUM PROTEINS
    Maria Linder; Fiscal Year: 1990
    ..of mammalian copper transport, namely the mechanisms by which cells take up copper from the plasma protein, ceruloplasmin. a major focus of the project is to examine the possibility that ceruloplasmin Cu is delivered by a mechanism ..
  30. IRON AND COPPER IN HEALTH AND DISEASE
    Christopher Vulpe; Fiscal Year: 2001
    ..Candidate genes will be identified by standard means and evaluated for a role in sla. 2) Characterize a novel ceruloplasmin homologue expressed in the brain and determine its role in iron and copper metabolism...
  31. BIOLOGICAL ROLES OF IRON IN HUMAN NUTRITION
    ZENA HARRIS; Fiscal Year: 2000
    ..In this autosomal recessive disorder, patients present in adulthood with evidence of ceruloplasmin deficiency and a marked parenchymal iron accumulation resulting in progressive organ damage and morbidity...
  32. Phase II Trial of Tetrathiomolybdate in Prostate Cancer
    David Smith; Fiscal Year: 2002
    ..and progression on computed tomography and bone scan and with the degree of copper depletion measured by serum ceruloplasmin level...
  33. MECHANISM OF ACTION OF NEUROCYTOTOXINS
    RONALD BORCHARDT; Fiscal Year: 1992
    ..and characterization of the products of oxidation of 5-HT by hydroxyl radical, generated in situ, and by human ceruloplasmin, a copper containing protein with oxidase activity, under both aerobic and anaerobic conditions...
  34. Ceruloplasmin Mediated Penile Endothelial Dysfunction in Type 1 Diabetes
    Kanchan Chitaley; Fiscal Year: 2008
    ..To test our general hypothesis that increased tissue specific penile expression of ceruloplasmin in diabetes results in impaired cavernosal vasodilation and penile endothelial dysfunction, we will complete ..
  35. MECHANISMS OF HYPOALBUMINEMIA IN ENDSTAGE RENAL DISEASE
    George Kaysen; Fiscal Year: 2001
    ..We will further establish the effect of KT/V, dialyzer permeability and reuse on changes in albumin, nutritional status and acute phase response. ..
  36. PHASE III TRIAL OF TETRATHIOMOLYBDATE IN PRIMARY BILIAR*
    George Brewer; Fiscal Year: 2007
    ..Abstract Not Provided ..
  37. NUTRITIONAL COPPER STATUS AND THE NERVOUS SYSTEM
    JOSEPH ROBERT PROHASKA; Fiscal Year: 2010
    ..AIM 4: We will test the hypothesis that limitation in Cu-dependent ferroxidases lead to lower brain iron and are responsible by comparing rats reared on an iron-fortified diet to restore brain iron. ..
  38. Managing Ionic Iron: Molecular Architecture and Mechanism of Cell Iron Metabolism
    Daniel J Kosman; Fiscal Year: 2010
    ..An understanding of how cells suppress this chemistry would make a significant contribution to our eventual elucidation of the molecular basis for the multitude of human pathologies often attributed in part to mismanaged ionic iron. ..
  39. Copper Transport in Lactation
    Maria Linder; Fiscal Year: 2009
    ..most of it from the liver and kidney to the mammary gland, where it rapidly appears in the milk and in milk ceruloplasmin. Cu in milk ceruloplasmin may be more bio-available to the infant than the other forms of Cu in the milk, ..
  40. COPPER METALLOBIOCHEMISTRY IN SACCHAROMYCES CEREVISAE
    DANIEL KOSMAN; Fiscal Year: 2002
    ..Thus, elucidation of the function and modulation of Mac1p in yeast will be broadly relevant to eukaryotic copper and iron metabolism in general. ..
  41. Iron Trafficking to Ribonucleotide Reductases
    DANIEL KOSMAN; Fiscal Year: 2006
    ..This work should provide new insight into the assembly of a critical iron prosthetic group in vivo and evidence that this process can be a target for intervention in a viral infection. ..
  42. ROLE OF CERULOPLASMIN IN IRON METABOLISM AND OVERLOAD
    Paul Fox; Fiscal Year: 2003
    ..A role for copper in iron metabolism has been known for about 70 years. The important role for ceruloplasmin (Cp) in iron metabolism in vivo has been reinforced by the identification of "aceruloplasminemia" patients ..
  43. Membrane Polarization and Endothelial Cell Motility
    Paul Fox; Fiscal Year: 2007
    ..Pharmacological agents based on these results may be useful for inhibition of tumor angiogenesis or to enhance collateral blood vessel formation and the healing of synthetic vascular grafts. [unreadable] [unreadable]..
  44. INFLAMMATATION, IRON AND FERRITINS IN IRON ABSORPTION
    Maria Linder; Fiscal Year: 2001
    ..This is important since very little is currently known about these process at the molecular level and aberrations result in chronic over-absorption and iron overload. This is an adaptive response which is poorly understood. ..
  45. The Aging Glomerulus
    Jocelyn Wiggins; Fiscal Year: 2008
    ..abstract_text> ..
  46. TRANSLATIONAL CONTROL MEDIATED BY MRNA STRUCTURE
    Marilyn Kozak; Fiscal Year: 2002
    ..The reason why 40S ribosome/factor complexes protect "extra" sequences, which are accessible to RNase in 80S initiation complexes, will be studied. ..
  47. Production of Recombinant Eukaryotic Ferroxidases as Protein Therapeutics
    DANIEL KOSMAN; Fiscal Year: 2008
    ..have been well characterized: the Fet3 protein from the yeast Saccharomyces cerevisiae, yFet3p, and human ceruloplasmin, hCp...
  48. Translational Control of Inflammatory Gene Expression
    Paul Fox; Fiscal Year: 2009
    ....
  49. BIOLOGICAL ROLES OF IRON IN HUMAN NUTRITION
    ZENA HARRIS; Fiscal Year: 2004
    ..In this autosomal recessive disorder, patients present in adulthood with evidence of ceruloplasmin deficiency and a marked parenchymal iron accumulation resulting in progressive organ damage and mortality...
  50. Workshop on Biolron in Thalassemia & Sickle Cell Disease
    Elizabeth Theil; Fiscal Year: 2002
    ..abstract_text> ..
  51. METALLOTHIONEIN AND ADRIAMYCIN CARDIOTOXICITY
    Y Kang; Fiscal Year: 2006
    ..abstract_text> ..
  52. IRON & OXYGEN BIOLOGY IN SCD, HH & BETA-THAL MICE
    Elizabeth Theil; Fiscal Year: 2002
    ..The resulting information will be used to help probe the efficiency of presently available and experimental chelators, not only in promoting iron excretion but also in the prevention of defined types of cellular damage. ..
  53. Copper Complexing with Tetrathiomolybdate in a Murine Model of Alzheimers Disease
    Joseph Quinn; Fiscal Year: 2007
    ..The efficacy and safety of the dose will be monitored during the treatment period by plasma ceruloplasmin levels, with the TM dose adjusted if necessary to optimize the degree of copper complexing...
  54. Oxidative Stress and Heart Failure by Copper Restriction
    Y James Kang; Fiscal Year: 2010
    ..Therefore, Cu supplementation is not an appropriate approach to rescue diabetic cardiomyopathy. ..
  55. Prefrontal cortex and memory storage
    Pramod K Dash; Fiscal Year: 2010
    ....