- Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the sla mouse
C D Vulpe
Howard Hughes Medical Institute and the Department of Medicine, University of California at San Francisco, 94143, USA
Nat Genet 21:195-9. 1999
..We describe here a novel gene, Heph, encoding a transmembrane-bound ceruloplasmin homologue that is mutant in the sla mouse and highly expressed in intestine...
- Ceruloplasmin is a NO oxidase and nitrite synthase that determines endocrine NO homeostasis
Vascular Medicine Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Nat Chem Biol 2:486-93. 2006
..We therefore hypothesized that the multicopper oxidase, ceruloplasmin, could oxidize NO to NO+, with subsequent hydration to nitrite...
- Clinical utility of copper, ceruloplasmin, and metallothionein plasma determinations in human neurodegenerative patients and their first-degree relatives
INIBIOLP Instituto de Investigac iones Bioquímicas de La Plata, CCT La Plata, CONICET UNLP, Catedra de Bioquimica y Biologia Molecular, Facultad de Ciencias Medicas, Universidad Nacional de La Plata, 60 y 120 1900 La Plata, Argentina
Brain Res 1319:118-30. 2010
The concentration of plasma copper, ceruloplasmin (CRP), non-ceruloplasmin-bound Cu (NCBC), and metallothioneins (MTs) were studied as putative biomarkers for neurodegenerative diseases in patients and in their first-degree relatives...
- Reactive oxygen species regulate ceruloplasmin by a novel mRNA decay mechanism involving its 3'-untranslated region: implications in neurodegenerative diseases
Special Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi 110 067, India
J Biol Chem 284:1873-83. 2009
b>Ceruloplasmin (Cp), a copper-containing protein, plays a significant role in body iron homeostasis as aceruloplasminemia patients and Cp knock-out mice exhibit iron overload in several tissues including liver and brain...
- Unexpected role of ceruloplasmin in intestinal iron absorption
Department of Cell Biology, The Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Cell Metab 2:309-19. 2005
..Ferroxidases are essential for normal iron homeostasis in most organisms. The paralogous vertebrate ferroxidases ceruloplasmin (Cp) and hephaestin (Heph) are considered to have nonidentical functions in iron transport: plasma Cp drives ..
- Copper and ceruloplasmin abnormalities in Alzheimer's disease
George J Brewer
Department of Human Genetics, University of Michigan, Ann Arbor, 48103, USA
Am J Alzheimers Dis Other Demen 25:490-7. 2010
..Serum copper and ceruloplasmin were measured by both enzymatic (eCp) and immunologic (iCp) methods in 28 patients with Alzheimer's disease ..
- Clinical and genetic association of serum ceruloplasmin with cardiovascular risk
W H Wilson Tang
Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, 9500 Euclid Ave, Desk J3 4, Cleveland, OH 44195, USA
Arterioscler Thromb Vasc Biol 32:516-22. 2012
b>Ceruloplasmin (Cp) is an acute-phase reactant that is increased in inflammatory diseases and in acute coronary syndromes...
- Role of ceruloplasmin in macrophage iron efflux during hypoxia
Department of Cell Biology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
J Biol Chem 278:44018-24. 2003
..We have investigated the mechanism of macrophage iron efflux, focusing on the role of ceruloplasmin (Cp), a copper protein with a potent ferroxidase activity that converts Fe2+ to Fe3+ in the presence of ..
- Excess of serum copper not related to ceruloplasmin in Alzheimer disease
Department of Neuroscience, AFaR Osp Fatebenefratelli, 00186, Rome, Italy
Neurology 64:1040-6. 2005
To assess the role of serum copper in relation to ceruloplasmin and other peripheral markers of inflammation in Alzheimer disease (AD).
- Ferroxidase activity is required for the stability of cell surface ferroportin in cells expressing GPI-ceruloplasmin
Ivana De Domenico
Department of Pathology, School of Medicine, University of Utah, 50 North Medical Drive, Salt Lake City, UT 84132, USA
EMBO J 26:2823-31. 2007
..in mice and humans with aceruloplasminemia, an iron overload disease due to mutations in the ferroxidase ceruloplasmin (Cp). In the absence of Cp Fpn is rapidly internalized and degraded...
- Ceruloplasmin metabolism and function
Nathan E Hellman
Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
Annu Rev Nutr 22:439-58. 2002
b>Ceruloplasmin is a serum ferroxidase that contains greater than 95% of the copper found in plasma...
- Oxidative stress in autism: increased lipid peroxidation and reduced serum levels of ceruloplasmin and transferrin--the antioxidant proteins
NYS Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, New York 10314, USA
Life Sci 75:2539-49. 2004
..Levels of major antioxidant proteins namely, transferrin (iron-binding protein) and ceruloplasmin (copper-binding protein) in the serum, were significantly reduced in autistic children as compared to their ..
- Ceruloplasmin regulates iron levels in the CNS and prevents free radical injury
Bharatkumar N Patel
Centre for Research in Neuroscience, The Montreal General Hospital Research Institute and McGill University, Montreal, Quebec, Canada, H3G 1A4
J Neurosci 22:6578-86. 2002
b>Ceruloplasmin is a ferroxidase that oxidizes toxic ferrous iron to its nontoxic ferric form. We have previously reported that a glycosylphosphatidylinositol-anchored form of ceruloplasmin is expressed in the mammalian CNS...
- Decreased serum ceruloplasmin levels characteristically aggravate nigral iron deposition in Parkinson's disease
Department of Neurology, Zhongshan Hospital and Shanghai Medical College, Fudan University, Shanghai, China
Brain 134:50-8. 2011
..red nucleus and frontal white matter of 45 patients with Parkinson's disease with decreased or normal serum ceruloplasmin levels, together with age- and gender-matched control subjects...
- A prognostic role for ceruloplasmin in the diagnosis of indolent and recurrent inflammation
R K Natesha
Department of Surgery, Meharry Medical College, Nashville, Tennessee
J Natl Med Assoc 84:781-4. 1992
b>Ceruloplasmin is increased in infections, inflammatory diseases, and neoplastic diseases and may be scarcely visible to the naked eye because it imparts a faint green color to the serum...
- Hepcidin treatment modulates the expression of divalent metal transporter-1, ceruloplasmin, and ferroportin-1 in the rat cerebral cortex and hippocampus
Key Laboratory of Cellular Physiology, Ministry of Education, Shanxi Medical University, Taiyuan, 030001, People s Republic of China
Biol Trace Elem Res 143:1581-93. 2011
..The linkage between hepcidin (Hepc) and ferroportin-1 (FPN1), the divalent metal transporter 1 (DMT1), and ceruloplasmin (CP) in the brain is unknown...
- The structure of the small laccase from Streptomyces coelicolor reveals a link between laccases and nitrite reductases
Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, v v i, Heyrovskeho nam 2, 162 06 Praha 6, Czech Republic
J Mol Biol 385:1165-78. 2009
..Three copper ions of type 1 lie close to one another near the surface of the central part of the trimer, and, effectively, a trimeric substrate binding site is formed in their vicinity...
- Endoplasmic reticulum quality control of unassembled iron transporter depends on Rer1p-mediated retrieval from the golgi
Molecular Membrane Biology Laboratory, RIKEN Discovery Research Institute, Saitama 351 0198, Japan
Mol Biol Cell 15:1417-24. 2004
..These findings provide clear evidence that the ER quality control of unassembled membrane proteins can be achieved by retrieval from the Golgi and that Rer1p serves as a specific sorting receptor in this process...
- Ceruloplasmin dysfunction and therapeutic potential for Parkinson disease
Oxidation Biology Laboratory, Florey Institute for Neuroscience and Mental Health, Parkville, Victoria, Australia
Ann Neurol 73:554-9. 2013
b>Ceruloplasmin is an iron-export ferroxidase that is abundant in plasma and also expressed in glia...
- Copper and ceruloplasmin status in serum of prostate and colon cancer patients
Shivananda B Nayak
Department of Biochemistry, Kasturba Medical College, Manipal 576 119
Indian J Physiol Pharmacol 47:108-10. 2003
Serum copper and ceruloplasmin levels were estimated in 20 patients each of prostate and colon cancer...
- Targeted gene disruption reveals an essential role for ceruloplasmin in cellular iron efflux
Z L Harris
Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
Proc Natl Acad Sci U S A 96:10812-7. 1999
..Affected individuals evidence iron accumulation in tissue parenchyma in association with absent serum ceruloplasmin. Genetic studies of such patients reveal inherited mutations in the ceruloplasmin gene...
- Phase II trial of copper depletion with tetrathiomolybdate as an antiangiogenesis strategy in patients with hormone-refractory prostate cancer
N Lynn Henry
Department of Internal Medicine, Division of Hematology, University of Michigan School of Medicine, Ann Arbor, Mich, USA
Oncology 71:168-75. 2006
..In tumor models, the copper-chelating agent tetrathiomolybdate (TM) has been shown to be antiangiogenic. We evaluated the antitumor activity of TM in patients with hormone-refractory prostate cancer (HRPC)...
- Biological effects of mutant ceruloplasmin on hepcidin-mediated internalization of ferroportin
First Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
Biochim Biophys Acta 1802:968-75. 2010
b>Ceruloplasmin plays an essential role in cellular iron efflux by oxidizing ferrous iron exported from ferroportin. Ferroportin is posttranslationally regulated through internalization triggered by hepcidin binding...
- Effects of cholesterol and inflammation-sensitive plasma proteins on incidence of myocardial infarction and stroke in men
Department of Community Medicine, Malmo University Hospital, Malmo, Sweden
Circulation 105:2632-7. 2002
..This study explored whether the cholesterol-related incidence of stroke and myocardial infarction is modified by plasma markers of inflammation in a large, population-based cohort with a long follow-up...
- Ceruloplasmin and superoxide dismutase (SOD1) in Parkinson's disease: a follow-up study
Institute of Pharmacy, Pharmacology and Toxicology, Department of Pharmacology and Toxicology, University of Iceland, Hofsvallagata 53, 107 Reykjavik, Iceland
J Neurol Sci 241:53-8. 2006
In this follow-up study concentration, oxidative activity and specific oxidative activity of ceruloplasmin (CP) in serum and the activity of superoxide dismutase (SOD1) in erythrocytes were reexamined in 28 of originally 40 patients with ..
- Screening disease-associated proteins from sera of patients with rheumatoid arthritis: a comparative proteomic study
Tian wang Li
Department of Rheumatology, Third Affiliated Hospital of Sun Yat Sen University, Guangzhou, Guangdong 510630, China
Chin Med J (Engl) 123:537-43. 2010
..This study was performed to screen candidate RA-associated serum proteins by comparative proteomics to provide research clues to early diagnosis and treatment of RA...
- Case-control studies on ceruloplasmin and superoxide dismutase (SOD1) in neurodegenerative diseases: a short review
Department of Pharmacology and Toxicology, University of Iceland, Iceland
J Neurol Sci 299:51-4. 2010
This short review describes a series of case-control studies on the concentration and oxidative activity of ceruloplasmin (CP) in serum and the activity of superoxide dismutase (SOD1) in erythrocytes in patients with Alzheimer's disease (..
- Role of ceruloplasmin in cellular iron uptake
C K Mukhopadhyay
Department of Cell Biology, The Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
Science 279:714-7. 1998
Individuals with hereditary ceruloplasmin (Cp) deficiency have profound iron accumulation in most tissues, which suggests that Cp is important for normal release of cellular iron...
- A multicopper ferroxidase involved in iron binding to transferrins in Dunaliella salina plasma membranes
Department of Biological Chemistry, The Weizmann Institute of Science, Rehovot 76100, Israel
J Biol Chem 282:8658-66. 2007
..We propose that the function of D-Fox in D. salina has been modified during evolution from redox-mediated to transferrin-mediated iron uptake, following a gene transfer event of transferrins from an ancestral animal cell...
- Expression of ferroportin1, hephaestin and ceruloplasmin in rat heart
Zhong Ming Qian
Laboratory of Iron Metabolism, Department of Applied Biology and Chemical Technology and National Key Laboratory of Chinese Medicine and Molecular Pharmacology Shenzhen, Hong Kong, PR China
Biochim Biophys Acta 1772:527-32. 2007
..Here, we investigated expression of iron exporters including ferroportin 1 (Fpn1), ceruloplasmin (CP) and hephaestin (Heph) and provided evidence for their existence in the heart...
- Ceruloplasmin fragmentation is implicated in 'free' copper deregulation of Alzheimer's disease
AFaR, Department of Neuroscience, Fatebenefratelli Hospital, Isola Tiberina, Rome, Italy
Prion 2:23-7. 2008
..We recently demonstrated that an excess of non-ceruloplasmin-copper (i.e...
- Features of ceruloplasmin in the cerebrospinal fluid of Alzheimer's disease patients
Concetta R Capo
Department of Biology, Tor Vergata University of Rome, Via della Ricerca Scientifica, 00133 Rome, Italy
Biometals 21:367-72. 2008
The level of the apo-form of the copper enzyme ceruloplasmin (CP) is an established peripheral marker in diseases associated with copper imbalance...
- Ceruloplasmin oxidation, a feature of Parkinson's disease CSF, inhibits ferroxidase activity and promotes cellular iron retention
Proteome Biochemistry, San Raffaele Scientific Institute, I 20132 Milan, Italy
J Neurosci 31:18568-77. 2011
Parkinson's disease is a neurodegenerative disorder characterized by oxidative stress and CNS iron deposition. Ceruloplasmin is an extracellular ferroxidase that regulates cellular iron loading and export, and hence protects tissues from ..
- Cerebrospinal fluid diagnostic markers correlate with lower plasma copper and ceruloplasmin in patients with Alzheimer's disease
Department of Psychiatry and Psychotherapy, Saarland University, Homburg Saar, Germany
J Neural Transm 113:1763-9. 2006
..of these cerebrospinal fluid (CSF) diagnostic markers with primary dependent variables blood Cu, Zn and ceruloplasmin (CB) and secondary with CSF profiles of Cu, Zn and neurotransmitters was determined...
- Frameshift and nonsense mutations in the gene for ATPase7B are associated with severe impairment of copper metabolism and with an early clinical manifestation of Wilson's disease
Institute of Psychiatry and Neurology, Second Department of Neurology, Warsaw, Poland
Clin Genet 68:524-32. 2005
..Patients with one or two SMs on their alleles had lower serum copper and ceruloplasmin and were younger when the first symptoms of the disease appeared, compared with individuals with two MMs...
- Disruption of ceruloplasmin and hephaestin in mice causes retinal iron overload and retinal degeneration with features of age-related macular degeneration
The F M Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
Proc Natl Acad Sci U S A 101:13850-5. 2004
..To determine whether the ferroxidase ceruloplasmin (Cp) and its homolog hephaestin (Heph) are important for retinal iron homeostasis, we studied retinas from ..
- Ceruloplasmin gene variations and substantia nigra hyperechogenicity in Parkinson disease
Institute for Medical Genetics, University of Tuebingen, Germany
Neurology 63:1912-7. 2004
..However, sequence variations in genes involved in iron metabolism have been linked to basal ganglia disorders. One of these is ceruloplasmin (Cp), which is vitally involved in iron transport across the cell membrane.
- Copper-dependent activation of hypoxia-inducible factor (HIF)-1: implications for ceruloplasmin regulation
Carl Ludwig Institute of Physiology, University of Leipzig, Germany
Blood 105:4613-9. 2005
..b>Ceruloplasmin, the main copper transport protein in the plasma and a known HIF-1 target in vitro, was also induced in vivo ..
- Role of hypoxia-inducible factor-1 in transcriptional activation of ceruloplasmin by iron deficiency
C K Mukhopadhyay
Department of Cell Biology, The Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
J Biol Chem 275:21048-54. 2000
A role of the copper protein ceruloplasmin (Cp) in iron metabolism is suggested by its ferroxidase activity and by the tissue iron overload in hereditary Cp deficiency patients...
- Lipid peroxidation, some extracellular antioxidants, and antioxidant enzymes in serum of patients with rheumatoid arthritis
Department of Biochemistry, Faculty of Medicine, Ataturk University, Erzurum, Turkey
Rheumatol Int 21:200-4. 2002
..Serum malondialdehyde and ceruloplasmin levels and the activity of CuZn superoxide dismutase were higher, while transferrin levels and the activities ..
- Ceruloplasmin and what it might do
Department of Biochemistry, School of Biochemistry and Immunology, Trinity College, Dublin, Ireland
J Neural Transm 114:777-81. 2007
The blue coloured plasma protein ceruloplasmin binds up to 95% of circulating copper, and has several possible functions...
- Lower serum ceruloplasmin levels correlate with younger age of onset in Parkinson's disease
Kersi J Bharucha
Department of Neurology, University of Oklahoma Health Sciences, Center and Veterans Administration, Medical Center, 711 Stanton L Young Blvd, Oklahoma City, OK 73104, USA
J Neurol 255:1957-62. 2008
b>Ceruloplasmin functions as a ferroxidase in iron metabolism. Parkinson's disease (PD) is characterized by an increase in brain iron...
- The regulation of cellular iron metabolism
Anita C G Chua
School of Medicine and Pharmacology, University of Western Australia, Fremantle, Western Australia, Australia
Crit Rev Clin Lab Sci 44:413-59. 2007
..Current knowledge on their roles in maintaining iron homeostasis and how their dysregulation leads to the pathogenesis of HH are discussed...
- Levels of ceruloplasmin, transferrin, and lipid peroxidation in the serum of patients with Type 2 diabetes mellitus
Department of Biochemistry, Medical School, Ataturk University, Erzurum 25240, Turkey
J Diabetes Complications 18:193-7. 2004
..Increased oxidant stress has been implicated in the pathogenesis of DM. An increase in serum ceruloplasmin (Cp) levels has also been reported in Type 2 DM. Cp permits the incorporation of iron into transferrin (Trf)...
- Analysis of the human hephaestin gene and protein: comparative modelling of the N-terminus ecto-domain based upon ceruloplasmin
Basharut A Syed
Department of Biochemistry and Molecular Biology, Royal Free and University College Medical School, London NW3 2PF, UK
Protein Eng 15:205-14. 2002
..It is a member of the family of copper oxidases that includes mammalian ceruloplasmin, factors V and VIII, yeast fet3 and fet5 and bacterial ascorbate oxidase...
- Parallel increase in urinary excretion rates of immunoglobulin G, ceruloplasmin, transferrin, and orosomucoid in normoalbuminuric type 2 diabetic patients
Department of Endocrinology, Diabetes and Geriatric Medicine, Akita University School of Medicine, Akita, Japan
Diabetes Care 27:1176-81. 2004
..plasma proteins with different molecular radii <55 A and different isoelectric points (pI), such as IgG, ceruloplasmin, transferrin, and orosomucoid, have been independently reported to precede the development of microalbuminuria ..
- The Menkes/Wilson disease gene homologue in yeast provides copper to a ceruloplasmin-like oxidase required for iron uptake
D S Yuan
Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 92:2632-6. 1995
..A biochemical hallmark of these diseases is a deficiency of copper in ceruloplasmin and other copper proteins found in extracytosolic compartments...
- Congestive heart failure in copper-deficient mice
Department of Pharmacology and Toxicology, University of Louisville, Louisville, Kentucky 40202, USA
Exp Biol Med (Maywood) 228:811-7. 2003
..This study shows that CuD leads to systolic and diastolic dysfunction in association with histopathological changes, which are indices commonly used to diagnose congestive heart failure...
- Serum ceruloplasmin levels correlate negatively with liver fibrosis in males with chronic hepatitis B: a new noninvasive model for predicting liver fibrosis in HBV-related liver disease
Da Wu Zeng
Liver Center, First Affiliated Hospital, Fujian Medical University, Taijiang District, Fuzhou, Fujian Province, China
PLoS ONE 8:e77942. 2013
This study aimed to investigate associations between ceruloplasmin (CP) levels, inflammation grade and fibrosis stages in patients with chronic hepatitis B (CHB) and to establish a noninvasive model to predict cirrhosis.
- Sustained increases of plasma homocysteine, copper, and serum ceruloplasmin after coronary artery bypass grafting
Jamie Y Jeremy
Bristol Heart Institute, Bristol Royal Infirmary, United Kingdom
Ann Thorac Surg 74:1553-7. 2002
..The aim of this study was to assess the perioperative levels of Hcy, copper, ceruloplasmin (CP), folate, and vitamin B12 in patients undergoing myocardial revascularization surgery.
- Genotype-phenotype correlation in Italian children with Wilson's disease
Department of Pediatrics, University of Naples Federico II, Naples, Italy
J Hepatol 50:555-61. 2009
..Wilson's disease phenotype is very variable for clinical and laboratory features. Our aim was to assess the role of the type of ATP7B disease causing mutations on Wilson's disease phenotype...
- Plasma ceruloplasmin ferroxidase activity correlates with the nigral sonographic area in Parkinson's disease patients: a pilot study
Department of Neurology, National Institute of Neurology and Neurosurgery, Mexico City, Mexico
Neurochem Res 36:2111-5. 2011
..001). Interestingly, plasma ferroxidase activity was inversely correlated with the SN size by TCS (R² = 0.31), suggesting a relationship between the two markers...
- Antioxidant potential, paraoxonase 1, ceruloplasmin activity and C-reactive protein concentration in diabetic retinopathy
Department of Pathophysiology and Endocrinology, Medical University of Silesia, Poland
Clin Exp Med 10:185-92. 2010
The aim of this study was to evaluate the ferric-reducing ability of serum (FRAS), paraoxonase 1 (PON1), ceruloplasmin serum oxidase activity and hsCRP level in patients with type1 diabetes mellitus without and with diabetic retinopathy...
- Ceruloplasmin and cardiovascular disease
P L Fox
Department of Cell Biology, The Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
Free Radic Biol Med 28:1735-44. 2000
..We and others have investigated the role of human ceruloplasmin (Cp) in oxidative processes because it the principal copper-containing protein in serum...
- Ceruloplasmin and myeloperoxidase in complex affect the enzymatic properties of each other
Alexej V Sokolov
Department of Molecular Genetics of the Institute for Experimental Medicine of the Russian Academy of Medical Sciences, Saint Petersburg, Russia
Free Radic Res 42:989-98. 2008
b>Ceruloplasmin (CP), the multicopper oxidase of plasma, interacts with myeloperoxidase (MPO), an enzyme of leukocytes, and inhibits its peroxidase and chlorinating activity...
- Ceruloplasmin is a better predictor of the long-term prognosis compared with fibrinogen, CRP, and IL-6 in patients with severe unstable angina
1st Cardiology Department, AHEPA, University Hospital, Thessaloniki, Greece
Angiology 60:50-9. 2009
We investigated the time course and prognostic value of fibrinogen (Fib), C-reactive protein (CRP), interleukin-6 (IL-6), and ceruloplasmin (CP) in patients with severe unstable angina.
- Lactoferrin and ceruloplasmin derivatized superparamagnetic iron oxide nanoparticles for targeting cell surface receptors
Ajay Kumar Gupta
Centre for Cell Engineering, Institute of Biomedical and Life Sciences, Joseph Black Building, University of Glasgow, Glasgow G12 8QQ, Scotland, United Kingdom
Biomaterials 25:3029-40. 2004
..In contradiction, lactoferrin or ceruloplasmin coated nanoparticles attached to the cell membrane, most likely to the cell expressed receptors and were not ..
- Placental ceruloplasmin homolog is regulated by iron and copper and is implicated in iron metabolism
The Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, United Kingdom
Am J Physiol Cell Physiol 282:C472-8. 2002
We previously reported an endogenous, membrane-bound Cu oxidase with homology to ceruloplasmin in BeWo cells, a placental choriocarcinoma cell line...
- Evidence for a critical role of ceruloplasmin oxidase activity in iron metabolism of Wilson disease gene knockout mice
Department of Gastroenterology, University Hospital, Heidelberg, Germany
J Gastroenterol Hepatol 25:1144-50. 2010
..Therefore, the present study was carried out to elucidate iron metabolism in Atp7b(-/-) mice, an animal model of Wilson disease...
- In vitro interaction between ceruloplasmin and human serum transferrin
Nguyêt Thanh Ha-Duong
Laboratoire ITODYS Interfaces, Traitements et Organisation des Systèmes, Université Paris Diderot, CNRS UMR 7086, Bâtiment Lavoisier, 15 rue Jean Antoine de Baïf, Paris Cedex 13, France
Biochemistry 49:10261-3. 2010
The thermodynamics of the interactions of serum apotransferrin (T) and holotransferrin (TFe(2)) with ceruloplasmin (Cp), as well as those of human lactoferrin (Lf), were assessed by fluorescence emission spectroscopy...
- Systemic levels of ceruloplasmin oxidase activity in allergic asthma and allergic rhinitis
Arzu Didem Yalcin
Internal Medicine, Allergy and Clinical Immunology Unit, Antalya Education and Research Hospital, Antalya, Turkey
Immunopharmacol Immunotoxicol 34:1047-53. 2012
The role of ceruloplasmin oxidase activity (COA) involving the interaction of oxidant and antioxidant balance in allergic diseases is still unknown.
- A new role for heme, facilitating release of iron from the bacterioferritin iron biomineral
Centre for Molecular and Structural Biochemistry, School of Chemistry, University of East Anglia, Norwich NR4 7TJ, United Kingdom
J Biol Chem 286:3473-83. 2011
..Finally, we show that the catalytic ferroxidase center, which is central to the mechanism of mineralization, is not involved in iron release; thus, core mineralization and release processes utilize distinct pathways...
- Serum ceruloplasmin protein expression and activity increases in iron-deficient rats and is further enhanced by higher dietary copper intake
Perungavur N Ranganathan
Department of Food Science and Human Nutrition, University of Florida, Gainesville, FL, USA
Blood 118:3146-53. 2011
..One point of intersection between the 2 metals is the liver-derived, multicopper ferroxidase ceruloplasmin (Cp) that is important for iron release from certain tissues...
- Multicopper oxidase-1 is a ferroxidase essential for iron homeostasis in Drosophila melanogaster
Department of Biochemistry, Kansas State University, Manhattan, KS 66506, USA
Proc Natl Acad Sci U S A 109:13337-42. 2012
..Given that MCO1 orthologues are present in all insect genomes analyzed to date, this discovery is an important step toward understanding iron metabolism in insects...
- The ceruloplasmin homolog hephaestin and the control of intestinal iron absorption
Gregory J Anderson
Iron Metabolism Laboratory, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane, Queensland 4029, Australia
Blood Cells Mol Dis 29:367-75. 2002
..Hephaestin is homologous to the plasma copper-containing protein ceruloplasmin, and all residues involved in copper binding and disulfide bond formation in ceruloplasmin are conserved in ..
- The activity of cholesterol esterase and ceruloplasmin are inversely related in the serum of men with atherosclerosis obliterans
Department of General Chemistry, Chair and Department of Clinical Biochemistry, Medical University, Poznan, Poland
Med Sci Monit 7:940-5. 2001
b>Ceruloplasmin is a copper-containing (2-glycoprotein and a member of the acute phase reactant family...
- The effects of nitric oxide-oxidase and putative glutathione-peroxidase activities of ceruloplasmin on the viability of cardiomyocytes exposed to hydrogen peroxide
Département de Chimie et de biochimie and Centre Biomed, Universite du Quebec a Montreal, Montreal, QC, Canada
Free Radic Biol Med 49:2019-27. 2010
b>Ceruloplasmin (CP), a ferroxidase (EC 188.8.131.52) and a scavenger of reactive oxygen species, is an important extracellular antioxidant. Bovine CP indeed protects the isolated heart under ischemia-reperfusion conditions...
- Comparison of the three-dimensional structures of recombinant human H and horse L ferritins at high resolution
P D Hempstead
Krebs Institute for Biomolecular Research, Department of Molecular Biology and Biotechnology, University of Sheffield, England
J Mol Biol 268:424-48. 1997
..L chains contain a group of glutamates associated with mineralisation within the iron storage cavity of the protein...
- Quantitative evaluation of expression of iron-metabolism genes in ceruloplasmin-deficient mice
The Third Department of Medicine, Shinshu University School of Medicine, Matsumoto 390 8621, Japan
Biochim Biophys Acta 1588:195-202. 2002
Aceruloplasminemia is an autosomal recessive disorder caused by mutations in the ceruloplasmin (CP) gene, and is characterized by a unique combination of neurovisceral iron overload and iron deficiency anemia...
- Crystal structure of Bfr A from Mycobacterium tuberculosis: incorporation of selenomethionine results in cleavage and demetallation of haem
Department of Biochemistry, University of Delhi South Campus, New Delhi, India
PLoS ONE 4:e8028. 2009
..In addition, this study provides evidence against the general belief that a selenium derivative of a protein represents its true physiological native structure...
- Isolation and partial nucleotide sequence of the laccase gene from Neurospora crassa: amino acid sequence homology of the protein to human ceruloplasmin
U A Germann
Proc Natl Acad Sci U S A 83:8854-8. 1986
..striking sequence homology to the carboxyl-terminal part of the third homology unit of the multicopper oxidase ceruloplasmin and to a smaller extent, to the low molecular weight blue copper proteins plastocyanin and azurin...
- A critical overview of the chemistry of copper-dependent low density lipoprotein oxidation: roles of lipid hydroperoxides, alpha-tocopherol, thiols, and ceruloplasmin
M J Burkitt
Gray Cancer Institute, Mount Vernon Hospital, Northwood, Middlesex, HA6 2JR, United Kingdom
Arch Biochem Biophys 394:117-35. 2001
..Finally, the mechanisms by which ceruloplasmin, a copper-containing plasma protein, can bring about LDL modification are discussed...
- Increased vulnerability to rotenone-induced neurotoxicity in ceruloplasmin-deficient mice
Department of Neurology and Rheumatology, Shinshu University School of Medicine, 3 1 1 Asahi, 390 8621 Matsumoto, Japan
Neurosci Lett 446:56-8. 2008
b>Ceruloplasmin (Cp) is the strongest ferroxidase in human plasma...
- Proteomic analysis of amniotic fluid in pregnancies with Klinefelter syndrome foetuses
Athanasios K Anagnostopoulos
Medical Genetics, Athens University School of Medicine, Athens, Greece
J Proteomics 73:943-50. 2010
..Samples were analysed by 2-DE, coupled with MALDI-TOF-MS analysis. Three proteins (Ceruloplasmin, Alpha-1-antitrypsin and Zinc-alpha-2-glycoprotein) were found to be up-regulated in samples obtained from ..
- Glycosylphosphatidylinositol-anchored ceruloplasmin is required for iron efflux from cells in the central nervous system
Suh Young Jeong
Centre for Research in Neuroscience, McGill University Health Centre, Montreal General Hospital Research Institute, Montreal, Quebec H3G 1A4, Canada
J Biol Chem 278:27144-8. 2003
b>Ceruloplasmin (Cp) is a ferroxidase that converts highly toxic ferrous iron to its non-toxic ferric form...
- The neurological presentation of ceruloplasmin gene mutations
Department of Clinical Genetics, NIHR, Birmingham Women s Hospital, Birmingham, UK
Eur Neurol 60:200-5. 2008
Aceruloplasminemia is an autosomal recessive disorder of iron metabolism resulting from mutations of the ceruloplasmin gene...
- A mutation in the ceruloplasmin gene is associated with systemic hemosiderosis in humans
Department of Medicine Neurology, Shinshu University School of Medicine, Matsumoto, Japan
Nat Genet 9:267-72. 1995
We identified a mutation in the ceruloplasmin (Cp) gene in a Japanese family with aceruloplasminemia, some of whose members showed extrapyramidal disorders, cerebellar ataxia, and diabetes mellitus...
- Binding and inhibition of myeloperoxidase (MPO): a major function of ceruloplasmin?
Department of Nephrology, Lund University, University Hospital, Sweden
Clin Exp Immunol 108:167-74. 1997
..wt of 130 kD showed affinity for MPO. The protein was identified as ceruloplasmin by N-terminal amino acid sequencing and immunochemistry...
- Patterns of correlation of plasma ceruloplasmin in sepsis
IASI CNR Center for Pathophysiology of Shock, Catholic University School of Medicine, Rome, Italy
J Surg Res 144:107-10. 2008
In sepsis, plasma ceruloplasmin (Cp, mg/L) is known to increase as part of the acute phase response...
- Interleukin-1β induces ceruloplasmin and ferroportin-1 gene expression via MAP kinases and C/EBPβ, AP-1, and NF-κB activation
Department Biology, Universita Roma Tre, 00146 Rome, Italy
Neurosci Lett 484:133-8. 2010
..able to increase iron efflux from glial cells through a coordinate induction of both ferroportin-1 (Fpn) and ceruloplasmin (Cp) synthesis...
- Aceruloplasminemia: molecular characterization of this disorder of iron metabolism
Z L Harris
Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
Proc Natl Acad Sci U S A 92:2539-43. 1995
b>Ceruloplasmin is an abundant alpha 2-serum glycoprotein that contains 95% of the copper found in the plasma of vertebrate species...
- Novel types of two-domain multi-copper oxidases: possible missing links in the evolution
Graduate School of Information Science, Nara Institute of Science and Technology, 8916 5 Takayama cho, Ikoma, 630 0101 Nara, Japan
FEBS Lett 553:239-44. 2003
..conspicuous combination of blue-copper and inter-domain trinuclear copper binding residues, which is common in ceruloplasmin and ascorbate oxidase but not in nitrite reductase, and therefore are considered to retain the characteristics ..
- The copper-iron connection in biology: structure of the metallo-oxidase Fet3p
Alexander B Taylor
Department of Biochemistry and the X ray Crystallography Core Laboratory, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
Proc Natl Acad Sci U S A 102:15459-64. 2005
..The mammalian ferroxidases ceruloplasmin and hephaestin are homologs of Fet3p...
- Oxidase activity of ceruloplasmin and concentrations of copper and zinc in serum of cancer patients
Karol Marcinkowski University of Medical Sciences, Poznan, Poland
J Trace Elem Med Biol 15:193-6. 2001
..b>Ceruloplasmin (Cp) carries up to 90% of Cu in plasma and performs ferroxidase, antioxidant and amine oxidase activity...
- Iron overload and antioxidative role of perivascular astrocytes in aceruloplasminemia
Department of Laboratory Medicine, Musashi Hospital, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan
Neuropathol Appl Neurobiol 32:170-6. 2006
Aceruloplasminemia (ACP) is an inherited disorder of iron metabolism caused by the lack of ceruloplasmin activity; the neuropathological hallmarks are excessive iron deposition, neuronal loss, bizarrely deformed astrocytes, and numerous '..
- Ceruloplasmin in neurodegenerative diseases
Institute for Experimental Medicine, St Petersburg, Russia
Brain Res Brain Res Rev 49:633-40. 2005
For decades, abnormalities in ceruloplasmin (Cp) synthesis have been associated with neurodegenerative disease...
- Diagnosis of Wilson's disease: a comprehensive review
Chloe M Mak
Department of Chemical Pathology, The Chinese University of Hong Kong, Hong Kong SAR, China
Crit Rev Clin Lab Sci 45:263-90. 2008
..high clinical suspicion, typical neurological symptoms, presence of Kayser-Fleischer rings, and reduced serum ceruloplasmin concentration. The conventional value of < 0.20 g/l is not a universal diagnostic value...
- Plasma peptidylglycine alpha-amidating monooxygenase (PAM) and ceruloplasmin are affected by age and copper status in rats and mice
Joseph R Prohaska
Department of Biochemistry and Molecular Biology, University of Minnesota Medical School Duluth, 1035 University Drive, 55812, USA
Comp Biochem Physiol B Biochem Mol Biol 143:360-6. 2006
..alpha-amidating monooxygenase (PAM ), an enzyme involved in peptide posttranslational activation, to ceruloplasmin (Cp), a ferroxidase involved in iron mobilization...
- Copper, ceruloplasmin and superoxide dismutase (SOD1) in patients with Down's syndrome
Department of Pharmacology and Toxicology, The Institute of Pharmacy, Pharmacology and Toxicology, University of Iceland, P O Box 8216, 128 Reykjavik, Iceland
Pharmacol Toxicol 89:320-5. 2001
..Copper was accordingly determined in plasma, ceruloplasmin concentration in serum, ceruloplasmin oxidative activity and ceruloplasmin specific oxidative activity (..
- Structural characterization of the ceruloplasmin: lactoferrin complex in solution
Department of Biomedical Sciences, University of Teramo, Teramo, Italy
J Mol Biol 371:1038-46. 2007
b>Ceruloplasmin is a copper protein found in vertebrate plasma, which belongs to the family of multicopper oxidases...
- Structural studies of bacterioferritin B from Pseudomonas aeruginosa suggest a gating mechanism for iron uptake via the ferroxidase center
Saroja K Weeratunga
Ralph N Adams Institute for Bioanalytical Chemistry and Department of Chemistry, University of Kansas, Multidisciplinary Research Building, 2030 Becker Drive, Room 220 E, Lawrence, Kansas 66047, USA
Biochemistry 49:1160-75. 2010
..C., Lawson, T. L., Lewin, A., Moore, G. R., and Le Brun, N. E. (2009) J. Am. Chem. Soc. 131, 6808-6813], indicate that not all bacterioferritins operate in the same manner...
- Increased urinary excretions of immunoglobulin g, ceruloplasmin, and transferrin predict development of microalbuminuria in patients with type 2 diabetes
The Department of Endocrinology, Diabetes, and Geriatric Medicine, Akita University School of Medicine, Hondo, Akita 010 8543, Japan
Diabetes Care 29:142-4. 2006
- Serum level and antioxidant activity of ceruloplasmin in preeclampsia
Obstetrics and Gynecology Ward, Tabriz University of Medical Sciences, Tabriz, Iran
Pak J Biol Sci 13:621-7. 2010
..This study was aimed to determine the serum level and antioxidant activity of ceruloplasmin in preeclamptic women with gestational age over than 28 weeks...
- Effects of development and iron status on ceruloplasmin expression in rat brain
Yan Zhong Chang
Laboratory of Brain Iron Metabolism, Department of Applied Biology and Chemical Technology, Hong Kong Polytechnic University, Kowloon, Hong Kong
J Cell Physiol 204:623-31. 2005
The increased iron content in the brain of subjects with aceruloplasminemia has implicated ceruloplasmin (CP) as a major factor in the regulation of regional brain iron content...
- Ceruloplasmin gene expression in the murine central nervous system
L W Klomp
Edward Mallinckrodt Department off Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Clin Invest 98:207-15. 1996
..of central nervous system iron accumulation and neuronal loss in this disease, cDNA clones encoding murine ceruloplasmin were isolated and characterized. RNA blot analysis using these clones detected a 3...
- Crystal structure of the ferritin from the hyperthermophilic archaeal anaerobe Pyrococcus furiosus
Department of Biotechnology, Delft University of Technology, Julianalaan 67, 2628 BC Delft, The Netherlands
J Biol Inorg Chem 12:615-30. 2007
..A preservation of the monomer fold, rather than the 24-mer assembly, appears to be the most important factor that protects the ferritin from inactivation by heat...
- Copper regulated synthesis, secretion and degradation of ceruloplasmin in a mouse immortalized hepatocytic cell line
Istituto Nazionale di Ricerca per gli Alimenti e la Nutrizione INRAN, Via Ardeatina 546, 00178 Rome, Italy
Cell Mol Biol (Noisy-le-grand) . 2005
b>Ceruloplasmin, a blue copper oxidase circulating in serum of all vertebrates, is a glycoprotein synthesized mainly in hepatocytes and secreted into plasma with six tightly bound atoms of copper per molecule...
- Ceruloplasmin and the extent of heart failure in ischemic and nonischemic cardiomyopathy patients
Department of Cardiology, Second Affiliated Hospital, Zhejiang University, College of Medicine, Hangzhou, Zhejiang 310009, China
Mediators Inflamm 2013:348145. 2013
b>Ceruloplasmin was elevated in patients with coronary heart disease, but the relationship between ceruloplasmin and heart failure was still unknown...
- Ceruloplasmin protects against rotenone-induced oxidative stress and neurotoxicity
Department of Medicine Neurology and Rheumatology, Shinshu University School of Medicine, Matsumoto 390 8621, Japan
Neurochem Res 36:2127-35. 2011
To clarify the neuroprotective property of ceruloplasmin and the pathogenesis of aceruloplasminemia, we generated ceruloplasmin-deficient (CP⁻/⁻) mice on the C57BL/10 genetic background and further treated them with a mitochondrial ..
- Ferrous binding to the multicopper oxidases Saccharomyces cerevisiae Fet3p and human ceruloplasmin: contributions to ferroxidase activity
Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
J Am Chem Soc 126:6579-89. 2004
..Saccharomyces cerevisiae Fet3p and human ceruloplasmin (hCp) are members of this family that exhibit ferroxidase activity...
- Hepatic iron overload associated with a decreased serum ceruloplasmin level in a novel clinical type of aceruloplasminemia
The First Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
Gastroenterology 131:240-5. 2006
Aceruloplasminemia is a novel hereditary iron overload disease caused by a mutation in the ceruloplasmin gene and characterized by a complete deficiency of serum ceruloplasmin and iron accumulation in the liver and brain.