l lactate dehydrogenase

Summary

Summary: A tetrameric enzyme that, along with the coenzyme NAD+, catalyzes the interconversion of LACTATE and PYRUVATE. In vertebrates, genes for three different subunits (LDH-A, LDH-B and LDH-C) exist.

Top Publications

  1. ncbi Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance
    Valeria R Fantin
    Department of Genetics, Harvard Medical School and Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA
    Cancer Cell 9:425-34. 2006
  2. pmc Persistent histidine-rich protein 2, parasite lactate dehydrogenase, and panmalarial antigen reactivity after clearance of Plasmodium falciparum monoinfection
    Jamshaid Iqbal
    Department of Microbiology, Faculty of Medicine, Kuwait University, P O Box 24923, Safat 13110, Kuwait
    J Clin Microbiol 42:4237-41. 2004
  3. pmc Mitochondrial lactate dehydrogenase is involved in oxidative-energy metabolism in human astrocytoma cells (CCF-STTG1)
    Joseph Lemire
    Department of Chemistry and Biochemistry, Laurentian University, Sudbury, Ontario, Canada
    PLoS ONE 3:e1550. 2008
  4. ncbi Upregulation of lactate dehydrogenase A by ErbB2 through heat shock factor 1 promotes breast cancer cell glycolysis and growth
    Y H Zhao
    Mitchell Cancer Institute, University of South Alabama, Mobile, AL 36604, USA
    Oncogene 28:3689-701. 2009
  5. ncbi Potential toxicity of nonregulated asbestiform minerals: balangeroite from the western Alps. Part 1: Identification and characterization
    Chiara Groppo
    Interdepartmental Center G Scansetti for Studies on Asbestos and Other Toxic Particulates, Department of Mineralogical and Petrological Sciences, Via Pietro Giuria, University of Torino, Torino, Italy
    J Toxicol Environ Health A 68:1-19. 2005
  6. ncbi Cytotoxic effects of the lipopolysaccharide from Pseudomonas fluorescens on neurons and glial cells
    Laurent Picot
    Laboratory of Cold Microbiology, University of Rouen, UPRES 2123, 55 rue Saint Germain, 27000 Evreux, France
    Microb Pathog 35:95-106. 2003
  7. pmc Plasmodium falciparum histidine-rich protein 2-based immunocapture diagnostic assay for malaria: cross-reactivity with rheumatoid factors
    J Iqbal
    Department of Microbiology, Faculty of Medicine, Kuwait University, Safat 13110, Kuwait
    J Clin Microbiol 38:1184-6. 2000
  8. pmc Assessment of the drug susceptibility of Plasmodium falciparum clinical isolates from africa by using a Plasmodium lactate dehydrogenase immunodetection assay and an inhibitory maximum effect model for precise measurement of the 50-percent inhibitory conc
    Halima Kaddouri
    Centre National de Référence du Paludisme, Laboratoire de Parasitologie, Hôpital Bichat Claude Bernard and Université René Descartes, Paris, France
    Antimicrob Agents Chemother 50:3343-9. 2006
  9. ncbi Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1
    G L Semenza
    Center for Medical Genetics, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 3914, USA
    J Biol Chem 271:32529-37. 1996
  10. ncbi Evidence supporting the existence of an activity-dependent astrocyte-neuron lactate shuttle
    L Pellerin
    Institut de Physiologie, Universite de Lausanne, Switzerland
    Dev Neurosci 20:291-9. 1998

Research Grants

  1. ACUTE RENAL FAILURE--IMPACT OF FLUORINATED ANESTHETICS
    RICHARD ZAGER; Fiscal Year: 2001
  2. Iron Therapy in Renal Disease: Potential Toxicities
    RICHARD ZAGER; Fiscal Year: 2008
  3. Diesel Exhaust Particle Modulation of Inflammation
    Jeanclare Seagrave; Fiscal Year: 2005
  4. Role of inflammation in manganese-induced neurotoxicity
    NIKOLAY FILIPOV; Fiscal Year: 2004
  5. Utility of rapid diagnostic tests for malaria
    Heidi Hopkins; Fiscal Year: 2007
  6. Lactate Transport as a Therapeutic Target in Glioma
    SAROJ PRIYANTHA MATHUPALA; Fiscal Year: 2010
  7. REGULATION OF THE ERYTHROPOIETIN GENE
    H Bunn; Fiscal Year: 2003
  8. Rapid ischemic tolerance: Ubiquitin-mediated structural reorganization
    Robert Meller; Fiscal Year: 2007
  9. The role of ADMA in the pathology of asthma
    Sandra Wells; Fiscal Year: 2007
  10. The role of cardiolipin apoptosis
    DIANE HICKSON BICK; Fiscal Year: 2007

Detail Information

Publications225 found, 100 shown here

  1. ncbi Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance
    Valeria R Fantin
    Department of Genetics, Harvard Medical School and Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA
    Cancer Cell 9:425-34. 2006
    ..These results demonstrate that LDH-A plays a key role in tumor maintenance...
  2. pmc Persistent histidine-rich protein 2, parasite lactate dehydrogenase, and panmalarial antigen reactivity after clearance of Plasmodium falciparum monoinfection
    Jamshaid Iqbal
    Department of Microbiology, Faculty of Medicine, Kuwait University, P O Box 24923, Safat 13110, Kuwait
    J Clin Microbiol 42:4237-41. 2004
    ..In conclusion, the OptiMAL-IT assay is more sensitive than the ICT Malaria Pf/Pv test for monitoring therapeutic responses after antimalarial therapy since the LDH activity ceases when the malarial parasite dies...
  3. pmc Mitochondrial lactate dehydrogenase is involved in oxidative-energy metabolism in human astrocytoma cells (CCF-STTG1)
    Joseph Lemire
    Department of Chemistry and Biochemistry, Laurentian University, Sudbury, Ontario, Canada
    PLoS ONE 3:e1550. 2008
    ..Taken together, this study implicates lactate as an important contributor to ATP metabolism in the brain, a finding that may significantly change our notion of how this important organ manipulates its energy budget...
  4. ncbi Upregulation of lactate dehydrogenase A by ErbB2 through heat shock factor 1 promotes breast cancer cell glycolysis and growth
    Y H Zhao
    Mitchell Cancer Institute, University of South Alabama, Mobile, AL 36604, USA
    Oncogene 28:3689-701. 2009
    ..This pathway may have a major role in regulating glucose metabolism in breast cancer cells. These novel findings have important implications for the design of new approaches to target ErbB2-overexpressing breast cancers...
  5. ncbi Potential toxicity of nonregulated asbestiform minerals: balangeroite from the western Alps. Part 1: Identification and characterization
    Chiara Groppo
    Interdepartmental Center G Scansetti for Studies on Asbestos and Other Toxic Particulates, Department of Mineralogical and Petrological Sciences, Via Pietro Giuria, University of Torino, Torino, Italy
    J Toxicol Environ Health A 68:1-19. 2005
    ..Data show that chemical composition, form, durability, and cell toxicity indicate balangeroite as a potentially harmful fibrous mineral that needs to be examined by further chemical and cellular tests...
  6. ncbi Cytotoxic effects of the lipopolysaccharide from Pseudomonas fluorescens on neurons and glial cells
    Laurent Picot
    Laboratory of Cold Microbiology, University of Rouen, UPRES 2123, 55 rue Saint Germain, 27000 Evreux, France
    Microb Pathog 35:95-106. 2003
    ..fluorescens induces apoptosis and a concomitant and limited necrosis, reveal the unexpected cytotoxicity of this endotoxin and provide the first demonstration of the apoptotic effect of a non-aeruginosa Pseudomonas on nerve cells...
  7. pmc Plasmodium falciparum histidine-rich protein 2-based immunocapture diagnostic assay for malaria: cross-reactivity with rheumatoid factors
    J Iqbal
    Department of Microbiology, Faculty of Medicine, Kuwait University, Safat 13110, Kuwait
    J Clin Microbiol 38:1184-6. 2000
    ..Our study shows that the PfHRP-2-based ICT assay gave a false-positive reaction in 26% of the patients who had rheumatoid factors, but were negative for malaria by microscopy...
  8. pmc Assessment of the drug susceptibility of Plasmodium falciparum clinical isolates from africa by using a Plasmodium lactate dehydrogenase immunodetection assay and an inhibitory maximum effect model for precise measurement of the 50-percent inhibitory conc
    Halima Kaddouri
    Centre National de Référence du Paludisme, Laboratoire de Parasitologie, Hôpital Bichat Claude Bernard and Université René Descartes, Paris, France
    Antimicrob Agents Chemother 50:3343-9. 2006
    ..The availability of this simple and highly sensitive pLDH immunodetection assay will provide an easier method for drug susceptibility testing of malaria parasites...
  9. ncbi Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1
    G L Semenza
    Center for Medical Genetics, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 3914, USA
    J Biol Chem 271:32529-37. 1996
    ..These results provide further evidence that the coordinate transcriptional activation of genes encoding glycolytic enzymes which occurs in hypoxic cells is mediated by HIF-1...
  10. ncbi Evidence supporting the existence of an activity-dependent astrocyte-neuron lactate shuttle
    L Pellerin
    Institut de Physiologie, Universite de Lausanne, Switzerland
    Dev Neurosci 20:291-9. 1998
    ..This set of data is consistent with the existence of an activity-dependent astrocyte-neuron lactate shuttle for the supply of energy substrates to neurons...
  11. ncbi Comparative structural analysis and kinetic properties of lactate dehydrogenases from the four species of human malarial parasites
    W Michael Brown
    Department of Biochemistry and Molecular Biology, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131, USA
    Biochemistry 43:6219-29. 2004
    ..pH studies indicate that inhibitor binding is independent of pH in the pH 6-8 range, suggesting that differences in dissociation constants for a specific inhibitor are not due to altered active site pK values among the four pLDH...
  12. ncbi Seasonal acclimatisation of muscle metabolic enzymes in a reptile (Alligator mississippiensis)
    Frank Seebacher
    School of Biological Sciences A08, University of Sydney, New South Wales 2006, Australia
    J Exp Biol 206:1193-200. 2003
    ..Our data indicate that biochemical acclimatisation is important in thermoregulation of reptiles and that it is not sufficient to base conclusions about their thermoregulatory ability entirely on behavioural patterns...
  13. ncbi Protection from oxidative stress-induced apoptosis in cortical neuronal cultures by iron chelators is associated with enhanced DNA binding of hypoxia-inducible factor-1 and ATF-1/CREB and increased expression of glycolytic enzymes, p21(waf1/cip1), and ery
    K Zaman
    Department of Neurology, Harvard Medical School and the Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
    J Neurosci 19:9821-30. 1999
    ..Altogether, these results suggest that iron chelators exert their neuroprotective effects, in part, by activating a signal transduction pathway leading to increased expression of genes known to compensate for hypoxic or oxidative stress...
  14. pmc The sensitivity of the OptiMAL rapid diagnostic test to the presence of Plasmodium falciparum gametocytes compromises its ability to monitor treatment outcomes in an area of Papua New Guinea in which malaria is endemic
    Ivo Mueller
    PNG Institute of Medical Research, P O Box 378, Madang 511, Papua New Guinea
    J Clin Microbiol 45:627-30. 2007
    ..falciparum gametocytes. This high sensitivity limits the use of pLDH-based tests in the monitoring of treatment outcomes in circumstances where gametocytemia is common...
  15. ncbi Evolutionary convergence in adaptation of proteins to temperature: A4-lactate dehydrogenases of Pacific damselfishes (Chromis spp.)
    Glenn C Johns
    Hopkins Marine Station, Stanford University, Pacific Grove, California1, USA
    Mol Biol Evol 21:314-20. 2004
    ....
  16. ncbi Pulmonary hypertension in patients with sickle cell disease: a longitudinal study
    Kenneth I Ataga
    Division of Hematology Oncology and Comprehensive Sickle Cell Program, University of North Carolina, Chapel Hill, NC, USA
    Br J Haematol 134:109-15. 2006
    ..Higher levels of fetal haemoglobin and treatment with hydroxycarbamide were observed more frequently in patients without PHT. Thirteen per cent of patients with no previous evidence of PHT developed PHT following 3 years of observation...
  17. ncbi Intercellular calcium signaling in astrocytes via ATP release through connexin hemichannels
    Charles E Stout
    Loma Linda University School of Medicine, Loma Linda, California 92350, USA
    J Biol Chem 277:10482-8. 2002
    ..Release of ATP through connexin hemichannels represents a novel signaling pathway for intercellular communication in astrocytes and other non-excitable cells...
  18. ncbi Hypoxia-inducible factors HIF-1alpha and HIF-2alpha in head and neck cancer: relationship to tumor biology and treatment outcome in surgically resected patients
    Nigel J P Beasley
    Oxford Centre for Head and Neck Oncology, Radcliffe Infirmary, Oxford OX2 6HE, United Kingdom
    Cancer Res 62:2493-7. 2002
    ..Expression of HIF-1alpha in surgically treated patients with HNSCC (n = 79) was associated with improved disease-free survival (P = 0.016) and overall survival (P = 0.027)...
  19. pmc LDH-A inhibition, a therapeutic strategy for treatment of hereditary leiomyomatosis and renal cell cancer
    Han Xie
    Department of Medicine, Division of Interdisciplinary Medicine and Biotechnology, Beth Israel Deaconess Medical Center, Harvard Medical School, and Department of Pathology, Brigham and Women s Hospital, Boston, MA 02215, USA
    Mol Cancer Ther 8:626-35. 2009
    ....
  20. pmc Evaluation of three parasite lactate dehydrogenase-based rapid diagnostic tests for the diagnosis of falciparum and vivax malaria
    Elizabeth A Ashley
    Epicentre, Paris, France
    Malar J 8:241. 2009
    ..In areas where non-falciparum malaria is common rapid diagnostic tests (RDTs) capable of distinguishing malaria species reliably are needed. Such tests are often based on the detection of parasite lactate dehydrogenase (pLDH)...
  21. pmc The contribution of lactic acid to acidification of tumours: studies of variant cells lacking lactate dehydrogenase
    M Yamagata
    Department of Medicine and Medical Biophysics, Ontario Cancer Institute Princess Margaret Hospital, Toronto, Canada
    Br J Cancer 77:1726-31. 1998
    ....
  22. pmc Lactate dehydrogenase as a biomarker of hemolysis-associated nitric oxide resistance, priapism, leg ulceration, pulmonary hypertension, and death in patients with sickle cell disease
    Gregory J Kato
    Vascular Medicine Branch, National Heart, Lung and Blood Institute, National Institutes of Health, 10 Center Dr, MSC 1476, Bldg 10CRC, Rm 5 5140, Bethesda, MD 20892, USA
    Blood 107:2279-85. 2006
    ..We propose that LDH elevation identifies patients with a syndrome of hemolysis-associated NO resistance, endothelial dysfunction, and end-organ vasculopathy...
  23. ncbi Cellular and molecular actions of dinitroaniline and phosphorothioamidate herbicides on Plasmodium falciparum: tubulin as a specific antimalarial target
    Brian J Fennell
    Department of Microbiology, Moyne Institute of Preventive Medicine, The University of Dublin Trinity College, Dublin, Ireland
    Mol Biochem Parasitol 145:226-38. 2006
    ..These data suggest that P. falciparum tubulin contains a dinitroaniline/phosphorothioamidate-binding site that is not conserved in humans and might be a target for new antimalarial drugs...
  24. pmc Assessment of the prozone effect in malaria rapid diagnostic tests
    Philippe Gillet
    Department of Clinical Sciences, Institute of Tropical Medicine ITM, Nationalestraat 155, B 2000 Antwerp, Belgium
    Malar J 8:271. 2009
    ..In this study, a panel of malaria RDTs was challenged with clinical samples with P. falciparum hyperparasitaemia (> 5% infected red blood cells)...
  25. ncbi Serum S100B is suitable for prediction and monitoring of response to chemoimmunotherapy in metastatic malignant melanoma
    A P Hamberg
    The Netherlands Cancer Institute Antoni van Leeuwenhoek Huis, Amsterdam, The Netherlands
    Melanoma Res 13:45-9. 2003
    ..16 microg/l, but nine showed a transient rise during immunotherapy. In conclusion, S100B levels are of value for predicting the response to and for monitoring patients during chemoimmunotherapy...
  26. ncbi Serum S100beta protein as a marker of disease activity in patients with malignant melanoma
    M Q Mohammed
    Melanoma Unit, Charing Cross Hospital, London, UK
    Med Oncol 18:109-20. 2001
    ..0156) and multivariate (p = 0.038; hazard ratio = 1.0108) analyses. Serum S100beta protein is a better indicator of disease activity in MM than LDH or ALP and is an independent predictor of survival in stage IV disease...
  27. ncbi The lactate/pyruvate shuttle in spermatozoa: operation in vitro
    F G Gallina
    Catedra de Quimica Biologica, Facultad de Ciencias Medicas, Universidad Nacional de Cordoba, Argentina
    Arch Biochem Biophys 308:515-9. 1994
    ..The operation of the shuttle would oxidize cytosolic NADH produced during aerobic glycolysis (or fructolysis) in spermatozoa of those species having an efficient lactate carrier in mitochondria...
  28. ncbi Prognostic factors and long-term survival in 585 patients with metastatic breast cancer treated with epirubicin-based chemotherapy
    M Ryberg
    Department of Oncology, Herlev Hospital, University of Copenhagen, Denmark
    Ann Oncol 12:81-7. 2001
    ..Analysis of prognostic factors in patients with metastatic breast cancer treated with epirubicin-based chemotherapy...
  29. ncbi Escherichia coli lipopolysaccharide potentiation and inhibition of rat neonatal microglia superoxide anion generation: correlation with prior lactic dehydrogenase, nitric oxide, tumor necrosis factor-alpha, thromboxane B2, and metalloprotease release
    A M Mayer
    Midwestern University, Chicago College of Osteopathic Medicine, Department of Pharmacology, Downers Grove, Illinois 60515, USA
    Shock 11:180-6. 1999
    ..Potential clinical implications of our findings are suggested by the fact that LPS levels similar to the ones used in this study have been observed in cerebrospinal fluid both in Gram-negative meningitis and sepsis...
  30. ncbi Tumor necrosis factor alpha is toxic to embryonic mesencephalic dopamine neurons
    S O McGuire
    Department of Pharmacology, Rush Presbyterian St. Luke's Medical Center, Chicago, IL 60612, USA
    Exp Neurol 169:219-30. 2001
    ..These data strongly suggest that TNFalpha mediates cell death in a sensitive population of DA neurons and support the potential involvement of proinflammatory cytokines in the degeneration of DA neurons in PD...
  31. pmc Use of malaria rapid diagnostic test to identify Plasmodium knowlesi infection
    Thomas F McCutchan
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 12735 Twinbrook Pkwy, Rockville, MD 20892, USA
    Emerg Infect Dis 14:1750-2. 2008
    ..We report the use of a rapid test to supplement microscopic analysis in distinguishing the 5 malaria species that infect humans...
  32. ncbi Comparative study of 7 fluorescent pseudomonad clinical isolates
    A Chapalain
    Laboratoire de Microbiologie du Froid, UPRES 2123, Universite de Rouen, 55 rue Saint Germain, Evreux 27000, France
    Can J Microbiol 54:19-27. 2008
    ..mosselii or even Pseudomonas aeruginosa...
  33. ncbi Staging and clinical prognostic factors for small-cell lung cancer
    A Argiris
    Northwestern University Medical School and Robert H. Lurie Comprehensive Cancer Center, Chicago, Illinois 60611, USA
    Cancer J 7:437-47. 2001
    ..Identification of risk factors for treatment-related mortality is important for the management of patients with SCLC...
  34. ncbi Serum lactate dehydrogenase levels at presentation predict outcome of patients with limited-stage small-cell lung cancer
    F Tas
    Institute of Oncology, University of Istanbul, Istanbul, Turkey
    Am J Clin Oncol 24:376-8. 2001
    ..Also, the prognostic value of LDH on overall survival was shown in multivariate analysis (p = 0.05). At the time of diagnosis, serum levels of LDH appear to have a significant relation to outcome in patients with limited-stage SCLC...
  35. ncbi Serum lactate dehydrogenase isoenzyme 1 and relapse in patients with nonseminomatous testicular germ cell tumors clinical stage I
    F E von Eyben
    Department of Clinical Chemistry, Odense University Hospital, Denmark
    Acta Oncol 40:536-40. 2001
    ..80%, p = 0.003, log-rank test). The role of S-LD-1 in the staging, prognostication and monitoring of patients with NSGCT clinical stage I should be further explored in a large, prospective study...
  36. ncbi Are responses to therapy of metastasized malignant melanoma reflected by decreasing serum values of S100beta or melanoma inhibitory activity (MIA)?
    M Deichmann
    Department of Dermatology, University of Heidelberg, Vossstrasse 2, 69115 Heidelberg, Germany
    Melanoma Res 11:291-6. 2001
    ..Applying classification and regression trees (CARTs), one-point measurements of CRP was shown to be the most relevant overall parameter...
  37. ncbi A comparison of two rapid field immunochromatographic tests to expert microscopy in the diagnosis of malaria
    Daniel Philippe Mason
    University of California School of Medicine, San Francisco, CA, USA
    Acta Trop 82:51-9. 2002
    ..falciparum and non-falciparum parasites increased with parasite density. Several explanations for these results are explored. Our results raise particular concern over batch quality variations of malaria rapid diagnostic devices (MRDDs)...
  38. pmc Lactobacillus plantarum ldhL gene: overexpression and deletion
    T Ferain
    Laboratoire de Genetique Moleculaire, Universite Catholique de Louvain, Louvain la Neuve, Belgium
    J Bacteriol 176:596-601. 1994
    ..Inactivation of the gene resulted in the absence of L-LDH activity and in exclusive production of the D isomer of lactate. However, the global concentration of lactate in the culture supernatant remained unchanged...
  39. ncbi Kinetic parameters and lactate dehydrogenase isozyme activities support possible lactate utilization by neurons
    Koffi M Kla
    Department of Pediatrics, University of Maryland School of Medicine, 655 W Baltimore Street, Baltimore, MD 21201 1559, USA
    Neurochem Res 32:597-607. 2007
    ..However, the kinetics of LDH in brain are consistent with the possible release of lactate by astrocytes and oxidative use of lactate for energy in synaptic terminals...
  40. ncbi Assessment of three new parasite lactate dehydrogenase (pan-pLDH) tests for diagnosis of uncomplicated malaria
    Carole Fogg
    Epicentre, 8 rue Saint Sabin, 75011, Paris, France
    Trans R Soc Trop Med Hyg 102:25-31. 2008
    ..falciparum malaria, and all pLDH tests became negative after treatment more quickly than the HRP2. Therefore the rapid test of choice for use with artemisinin-combination therapies in this area would be one of these new pLDH tests...
  41. pmc Evaluation of the Palutop+4 malaria rapid diagnostic test in a non-endemic setting
    David P J van Dijk
    Faculty of Health, Medicine and Life Sciences FHML, Maastricht, The Netherlands
    Malar J 8:293. 2009
    ....
  42. pmc Prognostic significance of serum S100B protein in high-risk surgically resected melanoma patients participating in Intergroup Trial ECOG 1694
    Ahmad A Tarhini
    University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA
    J Clin Oncol 27:38-44. 2009
    ..We evaluated adjuvant trial E1694 to more precisely define the prognostic significance of serum S100B in patients with high-risk resected melanoma...
  43. ncbi Lactate, not pyruvate, is neuronal aerobic glycolysis end product: an in vitro electrophysiological study
    A Schurr
    Department of Anesthesiology and Perioperative Medicine, University of Louisville, School of Medicine, Louisville, KY 40202, USA
    Neuroscience 147:613-9. 2007
    ....
  44. pmc Targeting aspartate aminotransferase in breast cancer
    Joshua Marshall Thornburg
    Department of Medicine, J G Brown Cancer Center, University of Louisville, KY 40202, USA
    Breast Cancer Res 10:R84. 2008
    ..Oxamate is an inhibitor of both LDH and AAT, and we hypothesised that oxamate may disrupt the metabolism and growth of breast adenocarcinoma cells...
  45. ncbi Membrane-bound L- and D-lactate dehydrogenase activities of a newly isolated Pseudomonas stutzeri strain
    Cuiqing Ma
    State Key Laboratory of Microbial Technology, Shandong University, Jinan, People s Republic of China
    Appl Microbiol Biotechnol 77:91-8. 2007
    ..Combining activity staining and previous proteomic analysis, the results suggest that there are two separate enzymes in P. stutzeri SDM, which play an important role in converting lactate to pyruvate...
  46. ncbi Prevention of neurotoxicity in hypoxic cortical neurons by the noble gas xenon
    Christian Petzelt
    University Hospital Charite, Clinic for Anesthesiology and Intensive Care, Experimental Anesthesiology, FH 31, Spandauer Damm 130, 14050 Berlin, Germany
    Life Sci 72:1909-18. 2003
    ....
  47. ncbi Plasmodium falciparum: development and validation of a measure of intraerythrocytic growth using SYBR Green I in a flow cytometer
    Shinji Izumiyama
    Department of Parasitology, National Institute of Infectious Diseases, Shinjuku ku, Tokyo, Japan
    Exp Parasitol 121:144-50. 2009
    ..The protocol was extended to merozoite counting as a sensitive assay of growth inhibition of the parasite...
  48. pmc Apoptosis of airway epithelial cells: human serum sensitive induction by the cathelicidin LL-37
    Y Elaine Lau
    Centre for Microbial Diseases and Immunity Research, Room 232, 2259 Lower Mall Research Station, University of British Columbia, Vancouver, BC V6T 1Z4 Canada
    Am J Respir Cell Mol Biol 34:399-409. 2006
    ..We propose that LL-37-induced apoptosis of epithelial cells at low serum tissue sites may have a protective role against bacterial infection...
  49. ncbi The protective effect of cardiac gene transfer of CuZn-sod in comparison with the cardioprotector monohydroxyethylrutoside against doxorubicin-induced cardiotoxicity in cultured cells
    M A I Abou El Hassan
    Department of Medical Oncology, Free University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Cancer Gene Ther 10:270-7. 2003
    ..Thus, a gene-therapy strategy involving overexpression of CuZn-sod to protect against doxorubicin-induced cardiotoxicity is not feasible with the currently available adenovirus vectors...
  50. ncbi Prognostic factors for survival in previously treated patients with metastatic renal cell carcinoma
    Robert J Motzer
    Geritourinary Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    J Clin Oncol 22:454-63. 2004
    ..To describe survival in previously treated patients with metastatic renal cell carcinoma (RCC) who are candidates for clinical trials of new agents as second-line therapy...
  51. ncbi LDH correlation with survival in advanced melanoma from two large, randomised trials (Oblimersen GM301 and EORTC 18951)
    Sanjiv S Agarwala
    St Luke s Cancer Center, Bethlehem, PA 18015, USA
    Eur J Cancer 45:1807-14. 2009
    ..1xupper limit of normal (ULN)]. Each stratification factor was assessed for an interaction with treatment on survival and an interaction was detected only for LDH...
  52. ncbi Mitochondrial lactate oxidation complex and an adaptive role for lactate production
    Takeshi Hashimoto
    Department of Integrative Biology, University of California, Berkeley, CA 94720 3140, USA
    Med Sci Sports Exerc 40:486-94. 2008
    ....
  53. ncbi Regular transfusion lowers plasma free hemoglobin in children with sickle-cell disease at risk for stroke
    Nelson E Lezcano
    Department of Neurology, School of Medicine, Medical College of Georgia, Augusta, GA 30912, USA
    Stroke 37:1424-6. 2006
    ..PFH has been associated with harmful endothelial actions including scavenging nitric oxide (NO). Whether PFH plays a role in stroke in SCD has not been examined...
  54. pmc Evaluation of the intra- and inter-specific genetic variability of Plasmodium lactate dehydrogenase
    Arthur M Talman
    Unité d Epidémiologie Moléculaire, Institut Pasteur in Cambodia 5 Boulevard Monivong BP983, Phnom Penh, Kingdom of Cambodia
    Malar J 6:140. 2007
    ..However a characterization of the efficiency of these tests and the proteins they detect is needed to maximize RDT sensitivity...
  55. pmc Evaluation of the SD FK70 malaria Ag Plasmodium vivax rapid diagnostic test in a non-endemic setting
    Philippe Gillet
    Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium
    Malar J 8:129. 2009
    ....
  56. pmc Test characteristics of the SD FK80 Plasmodium falciparum/Plasmodium vivax malaria rapid diagnostic test in a non-endemic setting
    Philippe Gillet
    Department of Clinical Medicine, Institute of Tropical Medicine, Nationalestraat 155, B 2000 Antwerp, Belgium
    Malar J 8:262. 2009
    ..The present study assessed its performance in a non-endemic setting...
  57. ncbi Elevated lactate dehydrogenase is an adverse predictor of outcome in HLA-matched sibling bone marrow transplant for acute myelogenous leukemia
    M Kalaycio
    Department of Hematologic Oncology and Blood Disorders, The Cleveland Clinic, Taussig Cancer Center, Cleveland, OH 44195, USA
    Bone Marrow Transplant 40:753-8. 2007
    ..70, 95% confidence interval 1.41-5.16, P=0.003). We conclude that LDH is an important adverse risk factor for survival and should be included in future studies of risk performed on larger patient cohorts...
  58. ncbi A major outbreak of severe acute respiratory syndrome in Hong Kong
    Nelson Lee
    Department of Medicine, Chinese University of Hong Kong, Hong Kong, China
    N Engl J Med 348:1986-94. 2003
    ..There has been an outbreak of the severe acute respiratory syndrome (SARS) worldwide. We report the clinical, laboratory, and radiologic features of 138 cases of suspected SARS during a hospital outbreak in Hong Kong...
  59. ncbi Thoracic neuroblastoma: outcome of incomplete resection
    Atsushi Horiuchi
    2nd Department of Surgery, Ehime University School of Medicine, 791 0295 Shitsukawa, Shigenobu cho, Ehime, Japan
    Pediatr Surg Int 20:714-8. 2004
    ..There was a stronger tendency for the maturation of neuroblastoma into ganglioneuroma in the thoracic group. Complete resection is not required for thoracic neuroblastoma regardless of the patient's age...
  60. ncbi Melanoma inhibiting activity protein (MIA), beta-2 microglobulin and lactate dehydrogenase (LDH) in metastatic melanoma
    M González Cao
    Medical Oncology Department, Institut Clinic de Malaties Hematologiques i Oncològiques ICMHO
    Anticancer Res 27:595-9. 2007
    ..Serum levels of melanoma markers may have a role in monitoring disease evolution in metastatic melanoma...
  61. ncbi Performance of the OptiMAL test for malaria diagnosis among suspected malaria patients at the rural health centers
    Jamshaid Iqbal
    Department of Microbiology, Faculty of Medicine, Kuwait University, Safat, Kuwait
    Am J Trop Med Hyg 68:624-8. 2003
    ....
  62. ncbi Electron acquisition system constructed from an NAD-independent D-lactate dehydrogenase and cytochrome c2 in Rhodopseudomonas palustris No. 7
    Shunsuke Horikiri
    Department of Bioresources Science, Graduate School of Science and Technology, Matsudo shi, Chiba University, Japan
    Biosci Biotechnol Biochem 68:516-22. 2004
    ..12 mM). The enzyme contained a FAD cofactor. Cytochrome c(2) was purified from strain No. 7 as an electrophoretically homogeneous protein. Its pI was 9.4. Cytochrome c(2) was reduced by incubating with D-LDH and D-lactate...
  63. ncbi D-lactate dehydrogenase is a member of the D-isomer-specific 2-hydroxyacid dehydrogenase family. Cloning, sequencing, and expression in Escherichia coli of the D-lactate dehydrogenase gene of Lactobacillus plantarum
    H Taguchi
    Department of Agricultural Chemistry, University of Tokyo, Japan
    J Biol Chem 266:12588-94. 1991
    ..The conserved residues in this family appear to be the residues involved in the substrate binding and the catalytic reaction, and thus to be targets for site-directed mutagenesis...
  64. pmc Partial reconstruction of in vitro gluconeogenesis arising from mitochondrial l-lactate uptake/metabolism and oxaloacetate export via novel L-lactate translocators
    Lidia de Bari
    Istituto di Biomembrane e Bioenergetica, CNR, Via G Amendola, 165 A 70126 Bari, Italy
    Biochem J 380:231-42. 2004
    ..The role of lactate/mitochondria interactions in gluconeogenesis is discussed...
  65. ncbi Partial and delayed release of troponin-I compared with the release of lactate dehydrogenase from necrotic cardiomyocytes
    Lijuan Li
    Department of Cardiology, C5 P, Leiden University Medical Centre, P O Box 9600, 2300 RC, Leiden, The Netherlands
    Pflugers Arch 448:146-52. 2004
    ..The delay of TnI release relative to LDH release may be explained by slow dissociation of TnI molecules from myofilaments and/or formation of TnI degradation products that are undetected by the currently used ELISA assay...
  66. ncbi Regulation of the cytotoxic effects of Pseudomonas fluorescens by growth temperature
    Laurent Picot
    Laboratory of Cold Microbiology, UPRES2123, University of Rouen, 55, rue Saint Germain, 27000 Evreux, France
    Res Microbiol 155:39-46. 2004
    ....
  67. ncbi Comparison of HRP2- and pLDH-based rapid diagnostic tests for malaria with longitudinal follow-up in Kampala, Uganda
    Heidi Hopkins
    University of California, San Francisco, San Francisco, California 94143, USA
    Am J Trop Med Hyg 76:1092-7. 2007
    ..RDTs may provide an effective strategy for improving rational delivery of antimalarial therapy; in Kampala, either test could dramatically decrease inappropriate presumptive treatments...
  68. ncbi Effects of temperature acclimation on lactate dehydrogenase of cod (Gadus morhua): genetic, kinetic and thermodynamic aspects
    Maxim Zakhartsev
    Department of Biology, University of Antwerp, Groenenborgerlaan 171, B 2020 Antwerp, Belgium
    J Exp Biol 207:95-112. 2004
    ....
  69. ncbi Meta-analysis: accuracy of rapid tests for malaria in travelers returning from endemic areas
    Arthur Marx
    University of Berne and MediX General Practice Network, Berne, Switzerland
    Ann Intern Med 142:836-46. 2005
    ..Microscopic diagnosis of malaria is unreliable outside specialized centers. Rapid tests have become available in recent years, but their accuracy has not been assessed systematically...
  70. ncbi Evaluation of a rapid diagnostic test specific for Plasmodium vivax
    Sun Hyung Kim
    Department of Laboratory Medicine, College of Medicine, Korea University, Seoul, Korea
    Trop Med Int Health 13:1495-500. 2008
    ..vivax-specific rapid diagnostic test may be useful for screening suspected malaria patients when sufficient material and human resources (e.g. trained microscopists) are unavailable for malaria diagnosis...
  71. ncbi Evolutionary implications of lactate dehydrogenases (LDHs) of hagfishes compared to lampreys: LDH cDNA sequences from Eptatretus burgeri, Paramyxine atami and Eptatretus okinoseanus
    Yoshikazu Nishiguchi
    Department of Pharmaceutical Practice, Faculty of Pharmaceutical Science, Toho University, Chiba, Japan
    Zoolog Sci 25:475-9. 2008
    ..There were differences in six amino acid residues (6, 10, 20, 156, 269, and 341) in LDHs of hagfishes. These differences might reflect the tolerance to high pressure and low temperature of LDHs from hagfishes at different habitat depths...
  72. ncbi Serum lactate dehydrogenase activity as a biomarker in children with sickle cell disease
    Sandra O'Driscoll
    Department of Paediatric Haematology, King s College School of Medicine, King s College Hospital, Denmark Hill, London, UK
    Br J Haematol 140:206-9. 2008
    ..LDH also correlated positively and significantly with TCD measurements in the middle and anterior cerebral artery circulations in the children with HbSS...
  73. ncbi Amyloid precursor protein cross-linking stimulates beta amyloid production and pro-inflammatory cytokine release in monocytic lineage cells
    C M Sondag
    Department Pharmacology, Physiology and Therapeutics, University of North Dakota School of Medicine and Health Sciences, Grand Forks, 58202, USA
    J Neurochem 97:449-61. 2006
    ..These data provide much needed insight into the function of amyloid precursor protein and provide potential therapeutic targets to limit inflammatory changes associated with the progression of Alzheimer's disease...
  74. ncbi Tyrosinase messenger RNA in peripheral blood is related to poor survival in patients with metastatic melanoma following interleukin-2-based immunotherapy
    Henrik Schmidt
    Department of Oncology bClinical Biochemistry, NBG, Aarhus University Hospital, Aarhus, Denmark
    Melanoma Res 15:409-16. 2005
    ..Additional studies are needed before the prognostic value of tyrosinase mRNA in metastatic melanoma can be firmly established. Further evaluation of the combined measurement of tyrosinase mRNA and LDH is warranted...
  75. ncbi Evaluation of a new Plasmodium lactate dehydrogenase assay (OptiMAL-IT) for the detection of malaria
    S Pattanasin
    Shoklo Malaria Research Unit, PO Box 46, Mae Sod 63110, Thailand
    Trans R Soc Trop Med Hyg 97:672-4. 2003
    ..For species other than P. falciparum, the sensitivity was 65% and specificity was 99%. The performance of the new test decreased markedly at low levels of parasitaemia...
  76. ncbi Colocalization of MCT1, CD147, and LDH in mitochondrial inner membrane of L6 muscle cells: evidence of a mitochondrial lactate oxidation complex
    Takeshi Hashimoto
    Exercise Physiology Laboratory, Dept of Integrative Biology, 5101 Valley Life Sciences Bldg, Univ of California, Berkeley, CA 94720 3140, USA
    Am J Physiol Endocrinol Metab 290:E1237-44. 2006
    ....
  77. ncbi The heat stability of Plasmodium lactate dehydrogenase-based and histidine-rich protein 2-based malaria rapid diagnostic tests
    Peter L Chiodini
    Department of Clinical Parasitology, Hospital for Tropical Diseases, London, UK
    Trans R Soc Trop Med Hyg 101:331-7. 2007
    ..The performance of malaria RDTs can be adversely affected at the temperatures to which they will be exposed when transported to, and used in, the rural tropics...
  78. pmc Rapid diagnosis of vivax malaria by the SD Bioline Malaria Antigen test when thrombocytopenia is present
    Sei Won Lee
    Department of Internal Medicine, Armed Forces Yangju Hospital, Gyeonggi do 463 040, Republic of Korea
    J Clin Microbiol 46:939-42. 2008
    ..In conclusion, the SD Bioline Malaria Antigen test is a rapid and accurate diagnostic method for vivax malaria, and a platelet count can facilitate a rapid diagnosis of malaria...
  79. ncbi Pleiotropic effects of lactate dehydrogenase inactivation in Lactobacillus casei
    Rosa Viana
    Biotechnology Department, Instituto de Agroquimica y Tecnologia de Alimentos, IATA CSIC, P O Box 73, 46100 Burjassot, Valencia, Spain
    Res Microbiol 156:641-9. 2005
    ..This second effect could be partly avoided by growing the cells under aeration, since NADH oxidases could account for NAD+ regeneration...
  80. ncbi Transport and metabolism of L-lactate occur in mitochondria from cerebellar granule cells and are modified in cells undergoing low potassium dependent apoptosis
    Anna Atlante
    Istituto di Biomembrane e Bioenergetica, Consiglio Nazionale delle Ricerche, Via G Amendola, 165 A 70126, Bari, Italy
    Biochim Biophys Acta 1767:1285-99. 2007
    ..In contrast, the putative L-lactate/pyruvate antiport decreased en route to apoptosis with characteristics of a competitive like inhibition in early apoptosis, and a mixed non-competitive like inhibition in late apoptosis...
  81. pmc Cerebrovascular disease associated with sickle cell pulmonary hypertension
    Gregory J Kato
    Vascular Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892 1476, USA
    Am J Hematol 81:503-10. 2006
    ..Clinicians should suspect occult cerebrovascular disease in sickle cell patients with pulmonary hypertension...
  82. ncbi [Serum markers for melanoma]
    S Ugurel
    Klinische Kooperationseinheit Dermato Onkologie, Deutsches Krebsforschungszentrum Heidelberg Universitätshautklinik Mannheim
    Hautarzt 56:173-84; 185-6. 2005
    ..Serum markers are also not suitable for screening or for the diagnosis of primary melanomas...
  83. pmc Sensitivity and specificity of dipstick tests for rapid diagnosis of malaria in nonimmune travelers
    T Jelinek
    Department of Infectious Diseases and Tropical Medicine, University of Munich, Munich, Germany
    J Clin Microbiol 37:721-3. 1999
    ..5% and a specificity of 99.4%. Dipstick tests have the potential of enhancing speed and accuracy of the diagnosis of P. falciparum malaria, especially if nonspecialized laboratories are involved...
  84. ncbi Comparison of prognostic significance of serum 5-S-Cysteinyldopa, LDH and S-100B protein in Stage III-IV malignant melanoma
    Teodóra Bánfalvi
    Department of Dermatology, National Institute of Oncology, Budapest, Hungary
    Pathol Oncol Res 8:183-7. 2002
    ..Among the studied serum markers S-100B protein and LDH proved to be similarly reliable in respect to the clinical outcome...
  85. pmc Evaluation of the ICT malaria P.f/P.v and the OptiMal rapid diagnostic tests for malaria in febrile returned travellers
    E Geoffrey Playford
    Centre for Infectious Diseases and Microbiology Laboratory Services, Institute of Clinical Pathology and Medical Research, Westmead Hospital, Westmead NSW 2145, Australia
    J Clin Microbiol 40:4166-71. 2002
    ..Despite the high sensitivity of the ICT P.f/P.v assay for P. falciparum malaria, caution is warranted before RDTs are widely adopted for the diagnosis of malaria in nonimmune patients or in countries where malaria is not endemic...
  86. pmc Comparison of two commercial assays with expert microscopy for confirmation of symptomatically diagnosed malaria
    Jamshaid Iqbal
    Department of Microbiology, Faculty of Medicine, Kuwait University, Kuwait
    J Clin Microbiol 40:4675-8. 2002
    ..However, our results raise particular concern over the sensitivity of the ICT Malaria Pf/Pv test for detection of P. vivax infection. Further developments appear necessary to improve the performance of the ICT Malaria Pf/Pv test...
  87. ncbi Outcomes and prognostic factors in 267 patients with severe acute respiratory syndrome in Hong Kong
    Kin Wing Choi
    Princess Margaret Hospital, Kowloon, Hong Kong, China
    Ann Intern Med 139:715-23. 2003
    ..Severe acute respiratory syndrome (SARS) has become a global public health emergency...
  88. pmc Evaluation of the OptiMAL rapid antigen test and species-specific PCR to detect placental Plasmodium falciparum infection at delivery
    Limangeni Mankhambo
    College of Medicine, University of Malawi, Blantyre, Malawi
    J Clin Microbiol 40:155-8. 2002
    ..Neither OptiMAL nor PCR testing of peripheral blood is adequately sensitive to detect all placental malaria infection, but a positive result by OptiMAL testing identifies women with a high proportion of low-birth-weight babies...
  89. ncbi Ultraviolet light-induced changes in the glucose-6-phosphate dehydrogenase activity of porcine corneas
    Toshio Tsubai
    Department of Biology, Faculty of Science and High Technology Research Center, Konan University, 8 9 1 Okamoto, Higashinadaku, Kobe, Hyogo 658 8501, Japan
    Cornea 21:495-500. 2002
    ....
  90. pmc Early death during chemotherapy in patients with small-cell lung cancer: derivation of a prognostic index for toxic death and progression
    U N Lassen
    Finsen Center, Department of Oncology, Rigshospitalet, National University Hospital, Copenhagen, Denmark
    Br J Cancer 79:515-9. 1999
    ..We suggest that other groups evaluate our algorithm and exclude poor prognosis patients from trials of dose intensification...
  91. ncbi Kinetic mechanism of the endogenous lactate dehydrogenase activity of duck epsilon-crystallin
    G G Chang
    Department of Biochemistry, National Defense Medical Center, Taipei, Taiwan, Republic of China
    Arch Biochem Biophys 284:285-91. 1991
    ....
  92. ncbi Inhibition of tert-butyl hydroperoxide-induced cell membrane bleb formation by alpha-tocopherol and glutathione
    H W Chen
    Department of Nutrition, Chung Shan Medical College, 40203, Taichung, Taiwan
    Food Chem Toxicol 38:1089-96. 2000
    ..These results indicated that intracellular GSH and alpha-tocopherol status are important to the TBH-induced cell membrane abnormality. Furthermore, TS plays a defensive role against blebbing when GSH is exhausted by TBH...
  93. ncbi Cloning of the D-lactate dehydrogenase gene from Lactobacillus delbrueckii subsp. bulgaricus by complementation in Escherichia coli
    N Bernard
    Laboratoire de Genetique Moleculaire, Universite Catholique de Louvain, Louvain la Neuve, Belgium
    FEBS Lett 290:61-4. 1991
    ..The open reading frame encoded a 333-amino acid protein, showing no similarity with known L-LDH sequences but closely related to L. casei D-hydroxyisocaproate dehydrogenase (D-HicDH)...
  94. ncbi Serum lactate dehydrogenase isoenzyme 1 and prediction of death in patients with metastatic testicular germ cell tumors
    F E von Eyben
    The Department of Clinical Chemistry, Odense University Hospital, Denmark
    Clin Chem Lab Med 39:38-44. 2001
    ..The findings have implications for the staging and treatment of patients with metastatic testicular germ cell tumors...
  95. ncbi Diphenyl diselenide reduces temporarily hyperglycemia: possible relationship with oxidative stress
    N B V Barbosa
    Departamento de Quimica, Centro de Ciencias Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, RS, CEP 97105 900, Brazil
    Chem Biol Interact 163:230-8. 2006
    ..Our findings suggest that diphenyl diselenide can be considered an anti-diabetogenic agent by exhibiting anti-hyperglycemic and antioxidant properties...
  96. pmc In vitro study of lovastatin interactions with amiodarone and with carbon tetrachloride in isolated rat hepatocytes
    A Z Krasteva
    Department of Pharmacology and Toxicology, Faculty of Pharmacy, Medical University, 2 Dunav Str, Sofia 1000, Bulgaria
    World J Gastroenterol 13:2198-204. 2007
    ..To investigate the interactions at a metabolic level between lovastatin, amiodarone and carbon tetrachloride in isolated rat hepatocytes...
  97. ncbi Fluvastatin ameliorates endotoxin induced multiple organ failure in conscious rats
    Chung Hua Chen
    Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan
    Resuscitation 74:166-74. 2007
    ..In this present study, we used fluvastatin, a HMG-CoA reductase inhibitor, to study its effects upon LPS-induced endotoxic shock in conscious rats...
  98. ncbi Protective effect of n-3 polyunsaturated fatty acids concentrate on isoproterenol-induced myocardial infarction in rats
    R Anandan
    Biochemistry and Nutrition Division, Central Institute of Fisheries Technology, Matsyapuri PO, Cochin, India
    Prostaglandins Leukot Essent Fatty Acids 76:153-8. 2007
    ..39+/-0.18 microg/g). The results of the present study indicate that the overall cardioprotective effect of PUFA concentrate is probably related to its ability to inhibit lipid accumulation by its hypolipidaemic property...
  99. ncbi Alpha-lipoic acid protects against hepatic ischemia-reperfusion injury in rats
    Ender Dulundu
    Department of 5th Surgery, Haydarpasa Numune Educational and Research Hospital, Istanbul, Turkey
    Pharmacology 79:163-70. 2007
    ..To evaluate the protective effect of alpha-lipoic acid in reducing oxidative damage after severe hepatic ischemia/reperfusion (IR) injury...
  100. ncbi Enzymic activities in two populations of purified rat islet beta-cells
    A Sener
    Laboratory of Experimental Medicine, Brussels Free University, B-1070 Brussels, Belgium
    Int J Mol Med 8:285-9. 2001
    ..These findings thus argue against a low expression of either low-Km hexokinase(s) or lactate dehydrogenase as major determinants of the glucose-sensing device in beta-cells...
  101. ncbi Hepatoprotection of Phyllanthus maderaspatensis against experimentally induced liver injury in rats
    V V Asha
    Molecular Ethnopharmacology Lab, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, Kerala 695014, India
    Fitoterapia 78:134-41. 2007
    ..The activity of hexane extracts of P. maderaspatensis was comparable to that of silymarin, the reference hepatoprotective drug...

Research Grants72

  1. ACUTE RENAL FAILURE--IMPACT OF FLUORINATED ANESTHETICS
    RICHARD ZAGER; Fiscal Year: 2001
    ....
  2. Iron Therapy in Renal Disease: Potential Toxicities
    RICHARD ZAGER; Fiscal Year: 2008
    ..Potential reasons for these differences will be assessed, with the ultimate goal of defining the safest way of administering parenteral irons to renal disease patients. ..
  3. Diesel Exhaust Particle Modulation of Inflammation
    Jeanclare Seagrave; Fiscal Year: 2005
    ....
  4. Role of inflammation in manganese-induced neurotoxicity
    NIKOLAY FILIPOV; Fiscal Year: 2004
    ..The long-term goal of the proposed studies is to understand the role of microglia and environmental contaminants in neurodegenerative diseases. ..
  5. Utility of rapid diagnostic tests for malaria
    Heidi Hopkins; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  6. Lactate Transport as a Therapeutic Target in Glioma
    SAROJ PRIYANTHA MATHUPALA; Fiscal Year: 2010
    ..Thus, we need new ways to target this deadly cancer. We plan to test a novel method to "pickle-the-tumor-to-death," while leaving healthy brain cells intact. ..
  7. REGULATION OF THE ERYTHROPOIETIN GENE
    H Bunn; Fiscal Year: 2003
    ..These studies should provide unique and highly relevant information about common mechanisms of oxygen sensing, signal transduction and gene regulation that enable organisms to adapt to hypoxia. ..
  8. Rapid ischemic tolerance: Ubiquitin-mediated structural reorganization
    Robert Meller; Fiscal Year: 2007
    ..Indeed, the long-term aim of these studies is to discover endogenous protective mechanisms that can be translated into effective rapid acting neuroprotective agents for stroke. [unreadable] [unreadable] [unreadable]..
  9. The role of ADMA in the pathology of asthma
    Sandra Wells; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  10. The role of cardiolipin apoptosis
    DIANE HICKSON BICK; Fiscal Year: 2007
    ..The role of these modified phospholipids in cyt c release will be determined. We will answer the question "is the loss of cyt c preceded by deacylation of CL?" [unreadable] [unreadable]..
  11. Treatment of ADHD in Pediatric Patients with Epilepsy
    Joseph Gonzalez Heydrich; Fiscal Year: 2007
    ..abstract_text> ..
  12. Perfusion preservation solution for recovery of Donation by Cardiac Death livers
    Charles Lee; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  13. DISORDERED BLOOD COAGULATION IN SICKLE CELL DISEASE
    Kenneth Ataga; Fiscal Year: 2006
    ..e., is the "hypercoagulability" observed in patients with SCD a primary cause of the vasoocclusion or is it simply a secondary event that is observed in this clinical setting. ..
  14. A Novel Neuroprotective Approach for Ischemia
    Zhi Gang Jiang; Fiscal Year: 2004
    ..Here we propose to develop PAN-811 as a neuroprotectant for global and focal ischemia. ..
  15. Novel therapeutics for chronic pain
    Paul Wood; Fiscal Year: 2005
    ....
  16. CLINICAL TRIALS AND MENTORING IN ONCOLOGY RESEARCH
    Robert Motzer; Fiscal Year: 2003
    ..One recently joined staff at MSKCC in the Genito-urinary Section. Mentoring of clinical trials is extended beyond fellowship to junior faculty members. ..
  17. Identification of the 1-methyladenine receptor
    SEAN PLACE; Fiscal Year: 2008
    ..Eventually, studies will be conducted that are designed to elucidate the details of the molecular mechanism of signal transduction during oocyte maturation. ..
  18. OTK18 Regulation in HIV-1 associated dementia
    Tsuneya Ikezu; Fiscal Year: 2009
    ..abstract_text> ..
  19. Single Cell Analysis of Cross Talk Among Kinase Pathways
    Stefan Kaluz; Fiscal Year: 2008
    ..These studies will provide additional information relating to our understanding of the consequencesof activationof kinase signaling pathwayswith respect to malignant transformation, aggressive tumor growth and survival. ..
  20. PEDIATRIC ONCOLOGY GROUP
    Susan Cohn; Fiscal Year: 2002
    ....
  21. The Role of SPARC in Neuroblastoma Angiogenesis
    Susan Cohn; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  22. Anti-Inflammatory and Anti-Oxidative Nutrition in Dialysis Patients
    Kamyar Kalantar Zadeh; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  23. Growth factor effects on dental pulp cells
    DOUGLAS LOBNER; Fiscal Year: 2008
    ..As a method of maintaining the viability of these cells we are proposing studying the effects of naturally occurring substances called growth factors on dental pulp cells. [unreadable] [unreadable] [unreadable]..
  24. Role of ubiquitin in quality control of lens proteins
    Fu Shang; Fiscal Year: 2010
    ..The proposed work will increase our knowledge of how the lens maintains its transparent function and will potentially identify targets of pharmaceutical interventions for prevention or treatment of age-related cataract. ..
  25. Protein ubiquitination based neuroprotection for stroke
    Robert Meller; Fiscal Year: 2006
    ....
  26. Glucose Signaling: Regulation of Enzyme Activity
    DONALD PETTIGREW; Fiscal Year: 2006
    ..coli. ..
  27. Legionella pneumophila developmental cycle & virulence
    PAUL STOKES HOFFMAN; Fiscal Year: 2011
    ..These studies should also provide insights relevant to other opportunistic environmental pathogens including oxiella, Burkholderia and species of Mycobacterium. ..
  28. Optimizing Heme Oxygenase Activity after CNS Hemorrhage
    Raymond Regan; Fiscal Year: 2009
    ..The ultimate goal is to reduce brain injury in tissue surrounding a blood clot, and to thereby improve the likelihood of survival and return to an independent, productive life. ..
  29. CANNABINOIDS AND NEUROPROTECTION IN CEREBRAL ISCHEMIA
    David Greenberg; Fiscal Year: 2008
    ....
  30. Central Adaptations to Creatine Supplementation in Older Men and Women
    ERIC RAWSON; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  31. New Topical Therapies for Psoriasis
    Mitchell Avery; Fiscal Year: 2007
    ..The goal of this project is to develop a safe and effective new drug for topical treatment of psoriasis. [unreadable] [unreadable] [unreadable]..
  32. GLUTATHIONE AND MITOCHONDRIA IN TOXIC RENAL INJURY
    Lawrence Lash; Fiscal Year: 2003
    ..This information may have therapeutic applications for prevention of renal cellular injury or for understanding mitochondrial diseases or age-related decreases that occur in mitochondrial function. ..
  33. FATTY ACID METABOLISM IN CARDIAC ISCHEMIA
    DIANE HICKSON BICK; Fiscal Year: 2002
    ..Location of a malonyl-CoA compartment that is inaccessible to CPT-I will shed light on the inconsistency between the high malonyl CoA content in heart and reliance on beta-oxidation. ..
  34. Toll-Like Receptors in Bacterial Antigen Induced HIV-LTR
    Ozlem Equils; Fiscal Year: 2004
    ..abstract_text> ..
  35. First Int'l Symposium on Childhood and Adolescent NHL
    Mitchell Cairo; Fiscal Year: 2003
    ..abstract_text> ..
  36. BIOLOGY OF HUMAN INTRAEPITHELIAL LYMPHOCYTES
    Ellen Ebert; Fiscal Year: 2002
    ..These studies will determine the mechanism of IEL chemotaxis toward secreted products of ECs, why IL-15 is more potent than IL-2 in inducing LAK activity by IELs, and how IL-10 and IL-12 augment this activity. ..
  37. BACTERIAL MODULATION OF LUNG INFLAMMATORY RESPONSE
    Thomas Russo; Fiscal Year: 2004
    ..g. hemolysin) and bacterially induced host response elements in directly mediating the pathogenesis of lung injury. ..
  38. CHEMICAL INDUCED NEPHROTOXICITY--SUCCINIMIDES
    GARY RANKIN; Fiscal Year: 2001
    ..Collectively, the results of these studies should add important, new knowledge about the nephrotoxic and urotoxic species of succinimides, cellular targets of the toxicant species and potential mechanisms of nephrotoxicity. ..
  39. MECHANISMS OF INJURY POTENTIATION BY GROWTH FACTORS
    DOUGLAS LOBNER; Fiscal Year: 2004
    ..It is believed that these studies will aid in determining under what conditions growth factor induced potentiation of cell death may be of concern regarding their therapeutic use, and how those concerns may be addressed. ..
  40. WILD DERIVED MOUSE STOCKS--NEW MODELS FOR AGING RESEARCH
    Richard Miller; Fiscal Year: 2004
    ....
  41. TISSUE-CRYSTAL INTERACTION CA OXALATE NEPHROLITHIASIS
    Saeed Khan; Fiscal Year: 2003
    ..We can follow various events of nephrolithiasis in the animal model and cats explore the outcome of renal epithelial cell exposure to oxalate and calcium oxalate crystals in the cell cultures. ..
  42. Nonablative AlloSCT in Refractory Autoimmune Disease
    Mitchell Cairo; Fiscal Year: 2003
    ....
  43. DEVELOPMENT OF NOVEL ANTIFUNGAL ANTIPC NATURAL PRODUCTS
    Mitchell Avery; Fiscal Year: 2001
    ....
  44. Effect of Age on Exercise-Induced Cardioprotection
    JOSEPH STARNES; Fiscal Year: 2003
    ..The results of this Aim will provide key direction for the effective design of further comprehensive studies using inhibitors and/or activators of specific proteins or signaling pathways. ..
  45. Endothelial Transduction of Shear Stress
    TIMOTHY NURKIEWICZ; Fiscal Year: 2003
    ..abstract_text> ..
  46. The role of ADMA in the pathology of asthma
    Sandra Wells; Fiscal Year: 2008
    ..To ensure that the candidate accomplishes her research and training goals, she will have an excellent mentor and advisors, rich academic surroundings, and strong institutional commitment. [unreadable] [unreadable] [unreadable]..
  47. CaP, crystal responsible for idiopathic nephrolithasis
    Saeed Khan; Fiscal Year: 2008
    ..Type density and size must conform to limits and specifications provided in the PHS 398Instructions. RESEARCH GRANT TABLE OF CONTENTS Page Numbers Face Page 1 Description, ..
  48. Effect of Inducible Antioxidants on Hemoglobin Toxicity
    Raymond F Regan; Fiscal Year: 2010
    ..The ultimate goal is to reduce brain injury in tissue surrounding a blood clot, and to thereby improve the likelihood of survival and return to an independent, productive life. ..
  49. AntiRetroviral Activities of NEBRI
    Tsuneya Ikezu; Fiscal Year: 2003
    ..The potential of NEBR1 to effect viral-host cell interactions is realistic, novel and contains therapeutic implications. ..
  50. 2007 Cellular Osmoregulation: Sensors, Tranducers & Regulators Gordon Research Co
    PAUL YANCEY; Fiscal Year: 2007
    ..In all aspects of the conference, the organizers are working to promote the involvement of women, minorities and people with disabilities. [unreadable] [unreadable] [unreadable]..
  51. AMINO ACID TRANSPORT IN HYPOXIC-ISCHEMIC ENCEPHALOPATHY
    Michael Weiss; Fiscal Year: 2003
    ..abstract_text> ..
  52. Mineral and Mechanical Properties of Bone
    Sarandeep Huja; Fiscal Year: 2005
    ..Future interventional studies will examine the mechanisms for the initial and the long-term adaptive response in material properties of bone. ..
  53. Dev & Testing of New Medications for Treatment of Emerging Infectious Diseases
    Mitchell Avery; Fiscal Year: 2006
    ..This allows LADDS infrastructure to inch forward now to the last stages of drug development that are achievable with academic economics. [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  54. A Novel Neuroprotective Approach for Ischemia
    Zhi Gang Jiang; Fiscal Year: 2007
    ..At the end of the phase II period, we expect to submit an IND application to the FDA to use PAN-811 for the treatment of transient ischemic stroke and initiate phase Ib clinical trials. [unreadable] [unreadable]..
  55. LIVER/LUNG INTERACTIONS DURING GRAM NEGATIVE ENDOTOXEMIA
    George Matuschak; Fiscal Year: 2003
    ....
  56. Reproductive Biochemistry of Testis Specific LDH-X
    Erwin Goldberg; Fiscal Year: 2008
    ..Completion of these specific aims will further our understanding of LDH-C4 function, of testis specific gene regulation and of macromolecular interactions necessary for normal spermatogenesis and sperm function. [unreadable] [unreadable]..
  57. OXYGEN SENSING AND SIGNAL TRANSDUCTION
    H Bunn; Fiscal Year: 2003
    ..abstract_text> ..
  58. MECHANISMS OF CADMIUM TOXICITY IN EPITHELIAL CELLS
    WALTER PROZIALECK; Fiscal Year: 2007
    ..Furthermore, the results of these studies could have more general implications regarding the mechanisms by which toxic substances affect living organisms. ..
  59. Identification of Novel Genes Expressed in Bowel Cancer Using Change Mediated Ant
    Jeffrey Hillman; Fiscal Year: 2007
    ..Such proteins are likely to be useful in monitoring treatment, diagnosing this disease, and in preventing it. [unreadable] [unreadable] [unreadable]..
  60. Sun Valley Workshop on Skeletal Biology
    David Burr; Fiscal Year: 2004
    ..An Advisory Panel is formed of session chairs. There are plans to advertise and distribute a summary of the workshop, partly using Web-based resources. ..
  61. SMALL BIOEFFECTOR MOLECULES OF STREPTOCOCCUS MUTANS
    Jeffrey Hillman; Fiscal Year: 2001
    ..In specific aim 5, a reporter gene-labeled construct of JH1140 will be mutagenized with Tn917 and mutants lacking positive regulators for mutacin 1140 expression will be isolated and analyzed. ..
  62. Sun Valley Workshop on Skeletal Biology
    David Burr; Fiscal Year: 2006
    ..There are plans to advertise and distribute a summary of the workshop, partly using Web-based resources. [unreadable] [unreadable] [unreadable] [unreadable]..
  63. SIGNAL TRANSDUCTION IN MYOCARDIAL ISCHEMIC INJURY
    Richard Vander Heide; Fiscal Year: 2001
    ..Experimental design will include morphologic, biochemical, and pharmacologic assessment of isolated myocytes subjected to myocardial ischemia. ..
  64. Genes of M. tuberculosis Induced During Human Infection
    Jeffrey Hillman; Fiscal Year: 2004
    ..abstract_text> ..
  65. Sun Valley Workshop on Skeletal Biology
    David Burr; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  66. Sun Valley Workshop on Skeletal Biology
    David Burr; Fiscal Year: 2007
    ..There are plans to advertise and distribute a summary of the workshop, partly using Web-based resources. [unreadable] [unreadable] [unreadable] [unreadable]..
  67. MODELS FOR TESTING CANDIDATE TOPICAL MICROBICIDES FOR CYTOTOXICITY AND ACTIVITY A
    Mary Lampe; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  68. MECHANOTRANSDUCTION IN BONE
    David Burr; Fiscal Year: 2003
    ..Data generated by this Program are intended to define some mechanisms by which fluid forces can regulate gene expression, and will attempt to validate these mechanisms by in vivo studies. ..
  69. MUSCULOSKELETAL TRAINING GRANT
    David Burr; Fiscal Year: 2006
    ..Two presentations were nominated for Young Investigator Awards by the ASBMR and the ORS. ..
  70. Sun Valley Workshop on Skeletal Biology
    David Burr; Fiscal Year: 2005
    ..An Advisory Panel is formed of session chairs. There are plans to advertise and distribute a summary of the workshop, partly using Web-based resources. ..