17 hydroxysteroid dehydrogenases

Summary

Summary: A class of enzymes that catalyzes the oxidation of 17-hydroxysteroids to 17-ketosteroids. EC 1.1.-.

Top Publications

  1. ncbi Expression of 3beta-hydroxysteroid dehydrogenase type 1, P450 aromatase, and 17beta-hydroxysteroid dehydrogenase types 1, 2, 5 and 7 mRNAs in human early and mid-gestation placentas
    Y Li
    Biocenter Oulu and Research Center for Molecular Endocrinology, WHO Collaborating Centre for Research on Reproductive Health, University of Oulu, FIN 90014 Oulu, Finland
    Placenta 26:387-92. 2005
  2. ncbi The role of 17 beta-hydroxysteroid dehydrogenases
    R Mindnich
    GSF National Research Center for Environment and Health, Institute of Experimental Genetics, Ingolstadter Landstr 1, 85764 Neuherberg, Germany
    Mol Cell Endocrinol 218:7-20. 2004
  3. ncbi Male pseudohermaphroditism caused by mutations of testicular 17 beta-hydroxysteroid dehydrogenase 3
    W M Geissler
    Department of Biochemistry, Merck Research Laboratories, Rahway, New Jersey 07065
    Nat Genet 7:34-9. 1994
  4. ncbi Expression cloning and characterization of human 17 beta-hydroxysteroid dehydrogenase type 2, a microsomal enzyme possessing 20 alpha-hydroxysteroid dehydrogenase activity
    L Wu
    Departments of Biochemistry, Merck Research Laboratories, Rahway, New Jersey 07065
    J Biol Chem 268:12964-9. 1993
  5. ncbi Differential expression of 17beta-hydroxysteroid dehydrogenase isozyme genes in prostate cancer and noncancer tissues
    Eitetsu Koh
    Department of Urology, School of Medicine, Kanazawa University, Ishikawa, Japan
    Prostate 53:154-9. 2002
  6. ncbi Cofactor hydrogen bonding onto the protein main chain is conserved in the short chain dehydrogenase/reductase family and contributes to nicotinamide orientation
    Rong Shi
    Oncology and Molecular Endocrinology Research Center, Laval University Medical Center CHUQ and Laval University, Quebec G1V 4G2, Canada
    J Biol Chem 279:16778-85. 2004
  7. ncbi 17Beta-hydroxysteroid dehydrogenase types 1 and 2 in human placenta: an immunohistochemical study with correlation to placental development
    J Takeyama
    Department of Pathology, Tohoku University School of Medicine, Sendai, Japan
    J Clin Endocrinol Metab 83:3710-5. 1998
  8. ncbi Binary and ternary crystal structure analyses of a novel inhibitor with 17beta-HSD type 1: a lead compound for breast cancer therapy
    Mausumi Mazumdar
    Laboratory of Molecular Endocrinology and Oncology, CHUL Research Center Centre Hospitalier de Université Laval, CHUQ and Laval University, Quebec, Canada, G1V 4G2
    Biochem J 424:357-66. 2009
  9. ncbi Oxidative 3alpha-hydroxysteroid dehydrogenase activity of human type 10 17beta-hydroxysteroid dehydrogenase
    Xue Ying He
    Department of Pharmacology, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA
    J Steroid Biochem Mol Biol 87:191-8. 2003
  10. ncbi Compartmentalization of type I 17 beta-hydroxysteroid oxidoreductase in the human ovary
    C Sawetawan
    Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center at Dallas 75235 9032
    Mol Cell Endocrinol 99:161-8. 1994

Detail Information

Publications194 found, 100 shown here

  1. ncbi Expression of 3beta-hydroxysteroid dehydrogenase type 1, P450 aromatase, and 17beta-hydroxysteroid dehydrogenase types 1, 2, 5 and 7 mRNAs in human early and mid-gestation placentas
    Y Li
    Biocenter Oulu and Research Center for Molecular Endocrinology, WHO Collaborating Centre for Research on Reproductive Health, University of Oulu, FIN 90014 Oulu, Finland
    Placenta 26:387-92. 2005
    ..Therefore, the action of 3beta-HSD1 and 17HSD2 on P biosynthesis in the placenta is countered by 17HSD5 and 17HSD7, which may provide an optimal level of P for the maintenance and progression of pregnancy...
  2. ncbi The role of 17 beta-hydroxysteroid dehydrogenases
    R Mindnich
    GSF National Research Center for Environment and Health, Institute of Experimental Genetics, Ingolstadter Landstr 1, 85764 Neuherberg, Germany
    Mol Cell Endocrinol 218:7-20. 2004
    ..Current knowledge on genetics, biochemistry and medical implications is presented in this review...
  3. ncbi Male pseudohermaphroditism caused by mutations of testicular 17 beta-hydroxysteroid dehydrogenase 3
    W M Geissler
    Department of Biochemistry, Merck Research Laboratories, Rahway, New Jersey 07065
    Nat Genet 7:34-9. 1994
    ..Four substitution and two splice junction mutations were identified in the 17 beta HSD3 genes of five unrelated male pseudohermaphrodites. The substitution mutations severely compromised the activity of the 17 beta-HSD type 3 isozyme...
  4. ncbi Expression cloning and characterization of human 17 beta-hydroxysteroid dehydrogenase type 2, a microsomal enzyme possessing 20 alpha-hydroxysteroid dehydrogenase activity
    L Wu
    Departments of Biochemistry, Merck Research Laboratories, Rahway, New Jersey 07065
    J Biol Chem 268:12964-9. 1993
    ..The amount of 17 beta-HSD type 2 mRNA in placenta was found to be high. The data suggest that the 17 beta-HSD type 2 cDNA encodes the microsomal 17 beta-HSD of human placenta, described by several laboratories...
  5. ncbi Differential expression of 17beta-hydroxysteroid dehydrogenase isozyme genes in prostate cancer and noncancer tissues
    Eitetsu Koh
    Department of Urology, School of Medicine, Kanazawa University, Ishikawa, Japan
    Prostate 53:154-9. 2002
    ..This study presents the differential expression of 17betaHSD isozyme genes in cancerous and noncancerous prostate tissues of in vivo samples...
  6. ncbi Cofactor hydrogen bonding onto the protein main chain is conserved in the short chain dehydrogenase/reductase family and contributes to nicotinamide orientation
    Rong Shi
    Oncology and Molecular Endocrinology Research Center, Laval University Medical Center CHUQ and Laval University, Quebec G1V 4G2, Canada
    J Biol Chem 279:16778-85. 2004
    ..This common feature reveals a general mechanism among the SDR family, providing a rational basis for inhibitor design against biologically relevant SDR targets...
  7. ncbi 17Beta-hydroxysteroid dehydrogenase types 1 and 2 in human placenta: an immunohistochemical study with correlation to placental development
    J Takeyama
    Department of Pathology, Tohoku University School of Medicine, Sendai, Japan
    J Clin Endocrinol Metab 83:3710-5. 1998
    ..17BetaHSD type 2, therefore, is considered to prevent the passage of excessive estrogens into the fetal circulation at endothelial cells of the intravillous fetal capillaries by catalyzing the inactivation ofE2 to E1...
  8. ncbi Binary and ternary crystal structure analyses of a novel inhibitor with 17beta-HSD type 1: a lead compound for breast cancer therapy
    Mausumi Mazumdar
    Laboratory of Molecular Endocrinology and Oncology, CHUL Research Center Centre Hospitalier de Université Laval, CHUQ and Laval University, Quebec, Canada, G1V 4G2
    Biochem J 424:357-66. 2009
    ..Such inhibitors that block oestrogen synthesis to suppress the sulfatase pathway producing oestradiol can be used in adjuvant therapies with oestrogen receptor blockade, opening a new orientation of breast cancer treatment...
  9. ncbi Oxidative 3alpha-hydroxysteroid dehydrogenase activity of human type 10 17beta-hydroxysteroid dehydrogenase
    Xue Ying He
    Department of Pharmacology, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA
    J Steroid Biochem Mol Biol 87:191-8. 2003
    ..The experimental results lead to the conclusion that mitochondrial 17beta-HSD10 plays a significant part in a non-classical androgen synthesis pathway along with microsomal retinol dehydrogenases...
  10. ncbi Compartmentalization of type I 17 beta-hydroxysteroid oxidoreductase in the human ovary
    C Sawetawan
    Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center at Dallas 75235 9032
    Mol Cell Endocrinol 99:161-8. 1994
    ..Both theca interna and granulosa cells of preantral and antral follicles exhibited 3 beta-HSD staining. Primary follicles did not exhibit detectable 3 beta-HSD in either granulosa or theca cells.(ABSTRACT TRUNCATED AT 250 WORDS)..
  11. pmc Expanded substrate screenings of human and Drosophila type 10 17beta-hydroxysteroid dehydrogenases (HSDs) reveal multiple specificities in bile acid and steroid hormone metabolism: characterization of multifunctional 3alpha/7alpha/7beta/17beta/20beta/21-H
    Naeem Shafqat
    Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Biochem J 376:49-60. 2003
    ....
  12. ncbi Multiple functions of type 10 17beta-hydroxysteroid dehydrogenase
    Song Yu Yang
    Department of Pharmacology, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA
    Trends Endocrinol Metab 16:167-75. 2005
    ..This versatile enzyme might provide a new drug target for neuronal excitability control and for intervention in Alzheimer's disease and certain cancers...
  13. ncbi High expression of steroid sulfatase mRNA predicts poor prognosis in patients with estrogen receptor-positive breast cancer
    Yasuo Miyoshi
    Department of Surgical Oncology, Osaka University Graduate School of Medicine, Osaka 565 0871, Japan
    Clin Cancer Res 9:2288-93. 2003
    ..e., aromatase, sulfatase, and 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1), was evaluated in patients with invasive breast cancer...
  14. pmc Human oestrogenic 17beta-hydroxysteroid dehydrogenase specificity: enzyme regulation through an NADPH-dependent substrate inhibition towards the highly specific oestrone reduction
    A Gangloff
    Oncology and Molecular Endocrinology Research Center, Laval University Medical Center (CHUL, 2705 Boulevard Laurier, , G1V 4G2, Canada
    Biochem J 356:269-76. 2001
    ....
  15. ncbi Abnormal expression of 17beta-hydroxysteroid dehydrogenases in breast cancer predicts late recurrence
    C Gunnarsson
    Department of Biomedicine and Surgery, Division of Oncology, Faculty of Health Sciences, , Sweden
    Cancer Res 61:8448-51. 2001
    ..71). These findings suggest that abnormal expression of 17beta-HSD isoforms has prognostic significance in breast cancer and that altered expression of these enzymes may have importance in breast cancer progression...
  16. ncbi Design and validation of specific inhibitors of 17beta-hydroxysteroid dehydrogenases for therapeutic application in breast and prostate cancer, and in endometriosis
    Joanna M Day
    Department of Endocrinology and Metabolic Medicine, Imperial College, London, London W2 1NY, UK
    Endocr Relat Cancer 15:665-92. 2008
    ....
  17. ncbi Building a multigenic model of breast cancer susceptibility: CYP17 and HSD17B1 are two important candidates
    H S Feigelson
    American Cancer Society, National Home Office, Atlanta, Georgia 30329 4251, USA
    Cancer Res 61:785-9. 2001
    ..05; 95% CI, 1.29-7.25). These findings suggest that breast cancer risk has a strong genetic component and supports the theory that the underlying mechanism of "complex traits" can be understood using a multigenic model of candidate genes...
  18. ncbi Human brain short chain L-3-hydroxyacyl coenzyme A dehydrogenase is a single-domain multifunctional enzyme. Characterization of a novel 17beta-hydroxysteroid dehydrogenase
    X Y He
    Departments of Pharmacology, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York 10314, USA
    J Biol Chem 274:15014-9. 1999
    ....
  19. ncbi Design, synthesis, and biological evaluation of (hydroxyphenyl)naphthalene and -quinoline derivatives: potent and selective nonsteroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) for the treatment of estrogen-dependent disease
    Martin Frotscher
    8 2 Pharmaceutical and Medicinal Chemistry, Saarland University, Saarbrucken, Germany
    J Med Chem 51:2158-69. 2008
    ....
  20. ncbi Characteristics of a highly labile human type 5 17beta-hydroxysteroid dehydrogenase
    I Dufort
    Medical Research Council Group in Molecular Endocrinology, CHUL Research Center and Laval University, Quebec, Quebec, Canada
    Endocrinology 140:568-74. 1999
    ....
  21. ncbi A 3D QSAR model of 17beta-HSD1 inhibitors based on a thieno[2,3-d]pyrimidin-4(3H)-one core applying molecular dynamics simulations and ligand-protein docking
    Sampo Karkola
    Laboratory of Organic Chemistry, Department of Chemistry, University of Helsinki, PO Box 55, 00014 Helsinki, Finland
    ChemMedChem 3:461-72. 2008
    ..The model will be used to guide structural modifications of 17beta-HSD1 inhibitors based on a thieno[2,3-d]pyrimidin-4(3H)-one core in order to improve the biological activity as well as in the design of novel 17beta-HSD1 inhibitors...
  22. ncbi Substituted 6-phenyl-2-naphthols. Potent and selective nonsteroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1): design, synthesis, biological evaluation, and pharmacokinetics
    Sandrine Marchais-Oberwinkler
    8 2 Pharmaceutical and Medicinal Chemistry, Saarland University, PO Box 15 11 50, D 66041 Saarbrucken, Germany
    J Med Chem 51:4685-98. 2008
    ..The 1-phenyl compound 32 showed a very high inhibitory activity for 17beta-HSD1 (IC50 = 20 nM) and good selectivity (17beta-HSD2 and ERs) and pharmacokinetic properties after peroral application...
  23. ncbi Advances in development of inhibitors of 17beta hydroxysteroid dehydrogenases
    Donald Poirier
    Laboratory of Medicinal Chemistry, CHUQ CHUL Research Center and Laval University, 2705 Laurier Boulevard, Québec Québec G1V4G2, Canada
    Anticancer Agents Med Chem 9:642-60. 2009
    ..The present review article gives a description of novel inhibitors of 17beta-HSDs that were published in 2003-2006...
  24. pmc Sexual differentiation of the zebra finch song system: potential roles for sex chromosome genes
    Michelle L Tomaszycki
    Department of Psychology and Program in Neuroscience, Michigan State University, East Lansing, MI, USA
    BMC Neurosci 10:24. 2009
    ..The present study examined the potential role for sex-biased gene expression during development of sexually dimorphic singing behavior and associated song nuclei in juvenile zebra finches...
  25. ncbi HSD17B1 and CYP17 polymorphisms and breast cancer risk among Chinese women in Singapore
    Anna H Wu
    Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA, USA
    Int J Cancer 104:450-7. 2003
    ..41, 95% CI=1.56-3.72; RR=4.39, 95% CI=1.71-11.30, respectively). The latter gene-parity effects were especially pronounced in postmenopausal women...
  26. ncbi Design, synthesis, biological evaluation and pharmacokinetics of bis(hydroxyphenyl) substituted azoles, thiophenes, benzenes, and aza-benzenes as potent and selective nonsteroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1)
    Emmanuel Bey
    Pharmaceutical and Medicinal Chemistry, Saarland University, PO Box 15 11 50, D 66041, Saarbrucken, Germany
    J Med Chem 51:6725-39. 2008
    ..Calculation of the molecular electrostatic potentials revealed a correlation between 17beta-HSD1 inhibition and the electron density distribution...
  27. pmc 17Beta-hydroxysteroid dehydrogenase type 1 and type 2 in human breast carcinoma: a correlation to clinicopathological parameters
    T Suzuki
    Department of Pathology, Tohoku University School of Medicine, Sendai, Japan
    Br J Cancer 82:518-23. 2000
    ..This study suggests that 17beta-HSD type 1 plays an important role in the regulation of in situ oestradiol production in hormone-dependent breast carcinomas...
  28. ncbi Characterization and localization of human type10 17beta-hydroxysteroid dehydrogenase
    X Y He
    Department of Pharmacology, New York State Institute for Basic Research in Developmental Disabilities, New York 10314, USA
    Eur J Biochem 268:4899-907. 2001
    ..This feature distinguishes it from all known 17beta-hydroxysteroid dehydrogenases, and endows mitochondria with the capability of modulating intracellular levels of the active forms of sex steroids...
  29. ncbi Complete amino acid sequence of human placental 17 beta-hydroxysteroid dehydrogenase deduced from cDNA
    H Peltoketo
    Department of Clinical Chemistry, University of Oulu, Finland
    FEBS Lett 239:73-7. 1988
    ..The deduced amino acid sequence also contained two peptides previously characterized from the proposed catalytic area of placental 17-HSD...
  30. ncbi Molecular epidemiology of sporadic breast cancer. The role of polymorphic genes involved in oestrogen biosynthesis and metabolism
    Katja Mitrunen
    Department of Industrial Hygiene and Toxicology, Finnish Institute of Occupational Health, Topeliuksenkatu 41 a A, FIN 00250, Helsinki, Finland
    Mutat Res 544:9-41. 2003
    ....
  31. ncbi Intratumoral concentration of sex steroids and expression of sex steroid-producing enzymes in ductal carcinoma in situ of human breast
    Rie Shibuya
    Department of Pathology, Tohoku University School of Medicine, Sendai, Japan
    Endocr Relat Cancer 15:113-24. 2008
    ..Therefore, estradiol and DHT may play important roles in the development of DCIS of the human breast...
  32. ncbi Characterization of Ke 6, a new 17beta-hydroxysteroid dehydrogenase, and its expression in gonadal tissues
    J Fomitcheva
    Nephrology Division, Department of Medicine, Children s Hospital, Boston, Massachusetts 02115, USA
    J Biol Chem 273:22664-71. 1998
    ....
  33. ncbi Differentiation-dependent expression of 17beta-hydroxysteroid dehydrogenase, type 10, in the rodent testis: effect of aging in Leydig cells
    Richard Ivell
    Institute for Hormone and Fertility Research, University of Hamburg, Falkenreid 88, 20251 Hamburg, Germany
    Endocrinology 144:3130-7. 2003
    ..Thus, perinatal expression of this enzyme in fetal Leydig cells may contribute to protecting these cells from estrogens and encourage androgen formation...
  34. ncbi New insights into the SAR and binding modes of bis(hydroxyphenyl)thiophenes and -benzenes: influence of additional substituents on 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) inhibitory activity and selectivity
    Emmanuel Bey
    Pharmaceutical and Medicinal Chemistry, Saarland University, P O Box 15 11 50, D 66041 Saarbrucken, Germany
    J Med Chem 52:6724-43. 2009
    ..It also shows a high selectivity (17beta-HSD2, ERalpha) and excellent pharmacokinetic properties after peroral application to rats...
  35. ncbi Inhibitors of 17beta-hydroxysteroid dehydrogenase type 1
    P Brozic
    Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia
    Curr Med Chem 15:137-50. 2008
    ..Their estrogenic/ proliferative activities and selectivities over other 17beta-hydroxysteroid dehydrogenases that are involved in local regulation of estrogen action (types 2, 7 and 12) are also presented...
  36. ncbi Amplification of HSD17B1 and ERBB2 in primary breast cancer
    Cecilia Gunnarsson
    Department of Biomedicine and Surgery, Faculty of Health Sciences, Linkoping University, Sweden
    Oncogene 22:34-40. 2003
    ..017), whereas amplification of ERRB2 was not. Amplification of HSD17B1 might be an indicator of adverse prognosis among ER-positive patients, and possibly a mechanism for decreased benefit from tamoxifen treatment...
  37. pmc Genetic determinants of mammographic density
    Christopher A Haiman
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA
    Breast Cancer Res 4:R5. 2002
    ..Changes in breast density are highly correlated with steroid hormone exposure...
  38. ncbi Two 17beta-hydroxysteroid dehydrogenases (17HSDs) of estradiol biosynthesis: 17HSD type 1 and type 7
    H Peltoketo
    Biocenter Oulu and WHO Collaborating Centre for Research on Reproductive Health, University of Oulu, Finland
    J Steroid Biochem Mol Biol 69:431-9. 1999
    ..The enhancer consists of several subunits, including a retinoic acid response element, the silencer has a binding motif for GATA factors, and the proximal promoter contains adjacent and competing AP-2 and Sp binding sites...
  39. ncbi Pseudo-symmetry of C19 steroids, alternative binding orientations, and multispecificity in human estrogenic 17beta-hydroxysteroid dehydrogenase
    Anne Gangloff
    Oncology and Molecular Endocrinology Research Center, CHUL Research Center and Laval University, Quebec, Canada, G1V 4G2
    FASEB J 17:274-6. 2003
    ....
  40. ncbi Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone
    Fernand Labrie
    Molecular Endocrinology and Oncology Research Center, Laval University Medical Center Centre Hospitalier de l Université Laval and Laval University, Quebec City, Quebec G1V 4G2, Canada
    Endocr Rev 24:152-82. 2003
    ....
  41. ncbi Involvement of up-regulation of 17beta-hydroxysteroid dehydrogenase type 1 in maintenance of intratumoral high estradiol levels in postmenopausal breast cancers
    Y Miyoshi
    Department of Surgical Oncology, Osaka University Medical School, Osaka, Japan
    Int J Cancer 94:685-9. 2001
    ..01). These results demonstrate that the increased conversion from E1 to E2 catalyzed by 17beta-HSD1 may play an important role in the maintenance of the intratumoral high E2 levels in postmenopausal patients...
  42. ncbi Expression of aromatase and 17beta-hydroxysteroid dehydrogenase types 1, 7 and 12 in breast cancer. An immunocytochemical study
    D Song
    First Teaching Hospital of Jilin University, Changchun, China
    J Steroid Biochem Mol Biol 101:136-44. 2006
    ..Moreover, the high expression of both 17beta-HSD type 12 and ERbeta in breast carcinoma cells may play a role in the development and/or progression of breast cancer...
  43. ncbi Analysis and characteristics of multiple types of human 17beta-hydroxysteroid dehydrogenase
    V Luu-The
    Medical Research Council Group in Molecular Endocrinology, Oncology and Molecular Endocrinology Research Center, Laval University Hospital Center CHUL and Laval University, Quebec, G1V 4G2, Sainte Foy, Canada
    J Steroid Biochem Mol Biol 76:143-51. 2001
    ..It is noteworthy that rat type 6 17beta-HSD also catalyzes the reaction in the oxidative direction. In this report, we analyze the different characteristics of the multiple types of human 17beta-HSD...
  44. ncbi Regulation of the gene for estrogenic 17-ketosteroid reductase lying on chromosome 17cen----q25
    Y Tremblay
    Department of Pediatrics, University of California, San Francisco 94143
    J Biol Chem 264:20458-62. 1989
    ..By contrast, cAMP decreases estrogenic 17KSR mRNA in primary cultures of human cytotrophoblasts and human granulosa cells, a pattern of tropic regulation that differs from other steroidogenic enzyme mRNAs...
  45. ncbi Characterization of cDNAs for human estradiol 17 beta-dehydrogenase and assignment of the gene to chromosome 17: evidence of two mRNA species with distinct 5'-termini in human placenta
    V Luu The
    Department of Molecular Endocrinology, Laval University Medical Centre, Quebec, Canada
    Mol Endocrinol 3:1301-9. 1989
    ....
  46. ncbi Estradiol-adenosine hybrid compounds designed to inhibit type 1 17beta-hydroxysteroid dehydrogenase
    Donald Poirier
    Oncology and Molecular Endocrinology Research Center, CHUQ Pavillon CHUL and Université Laval, Quebec G1V 4G2, Canada
    J Med Chem 48:8134-47. 2005
    ..Moreover, the 3D-structure analysis of EM-1,745 complexed with type 1 17beta-HSD showed key interactions with both substrate- and cofactor-binding sites...
  47. ncbi Localization of type 8 17beta-hydroxysteroid dehydrogenase mRNA in mouse tissues as studied by in situ hybridization
    Georges Pelletier
    Oncology and Molecular Endocrinology Research Center, Laval University Hospital CHUL, Quebec, Canada
    J Histochem Cytochem 53:1257-71. 2005
    ..In the lung, type 8 17beta-HSD mRNA was detected in bronchial epithelial cells and walls of pulmonary arteries. The present data suggest that type 8 17beta-HSD can exert its action to downregulate E2 levels in a large variety of tissues...
  48. pmc Biochemical factors governing the steady-state estrone/estradiol ratios catalyzed by human 17beta-hydroxysteroid dehydrogenases types 1 and 2 in HEK-293 cells
    Daniel P Sherbet
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8857, USA
    Endocrinology 150:4154-62. 2009
    ..These findings suggest that additional structural features, beyond the lack of a specific arginine residue, disfavor NADPH binding and thus support E2 oxidation by 17betaHSD2 in intact cells...
  49. ncbi Multifunctionality of human 17beta-hydroxysteroid dehydrogenases
    Gabriele Moeller
    GSF National Research Center of Environment and Health, Institute of Experimental Genetics, Genome Analysis Center, Neuherberg, Germany
    Mol Cell Endocrinol 248:47-55. 2006
    ..The issue of such multifunctionality is the topic of this review...
  50. ncbi Unusual charge stabilization of NADP+ in 17beta-hydroxysteroid dehydrogenase
    C Mazza
    Laboratoire de Cristallographie et Cristallogenese des Proteines, Institut de Biologie Structurale J P Ebel, CEA CNRS, 41, avenue des Martyrs, F 38027 Grenoble cedex, France
    J Biol Chem 273:8145-52. 1998
    ..Analysis of the catalytic properties of, and estradiol binding to, the two mutants suggests that the His221-steroid O3 hydrogen bond plays an important role in substrate specificity...
  51. ncbi Recent advances in 17beta-hydroxysteroid dehydrogenases
    Cornelia Prehn
    Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Institute of Experimental Genetics, Genome Analysis Center, Neuherberg, Germany
    J Steroid Biochem Mol Biol 114:72-7. 2009
    ..This review will focus on identities of 17beta-HSDs and recent advances in analyses of their physiological roles in steroid and lipid metabolism. It will also address the potential of metabolomics in drug development...
  52. pmc A novel 17beta-hydroxysteroid dehydrogenase in the fungus Cochliobolus lunatus: new insights into the evolution of steroid-hormone signalling
    T Lanisnik Rizner
    Institute of Biochemistry, Medical Faculty, Vrazov trg 2, 1000 Ljubljana, Slovenia
    Biochem J 337:425-31. 1999
    ..17beta-HSDcl is the first discovered fungal 17beta-hydroxysteroid dehydrogenase belonging to this family. The primary structure of this enzyme may therefore help to elucidate the evolutionary history of steroid dehydrogenases...
  53. ncbi New development in intracrinology of breast carcinoma
    Hironobu Sasano
    Department of Pathology, Tohoku University School of Medicine, Sendai, Japan
    Breast Cancer 13:129-36. 2006
    ..Therefore, it will become very important to examine the intratumoral levels of 17beta-HSD type 1 and STS in the resected specimens of human breast carcinoma as potential targets of novel endocrine therapy in the near future...
  54. ncbi Dehydroepiandrosterone and dihydrotestosterone recognition by human estrogenic 17beta-hydroxysteroid dehydrogenase. C-18/c-19 steroid discrimination and enzyme-induced strain
    Q Han
    Medical Research Council Group in Molecular Endocrinology, CHUL Research Center and Laval University, Ste Foy, Quebec G1V 4G2, Canada
    J Biol Chem 275:1105-11. 2000
    ..The electron density of DHEA also revealed a distortion of its 17-ketone toward a beta-oriented form, which approaches the transition-state conformation for DHEA reduction...
  55. ncbi A link between lung androgen metabolism and the emergence of mature epithelial type II cells
    Pierre R Provost
    Laboratory of Ontogeny and Reproduction, Department of Obstetrics and Gynecology, and Centre de Recherche en Biologie de la Reproduction, Faculty of Medicine, Laval University, Quebec, Quebec, Canada
    Am J Respir Crit Care Med 170:296-305. 2004
    ..The production of androgens after the emergence of mature PTII cells should negatively regulate PTII cell maturation and, thus, a role for androgens in cell reprogramming is suggested...
  56. ncbi Crystal structures of the multispecific 17beta-hydroxysteroid dehydrogenase type 5: critical androgen regulation in human peripheral tissues
    Wei Qiu
    Oncology and Molecular Endocrinology Research Center, Centre Hospitalier de l Université Laval Medical Center CHUL and Laval University, Sainte Foy, Quebec, Canada G1V 4G2
    Mol Endocrinol 18:1798-807. 2004
    ..These structures have provided a dynamic view of the enzyme reaction converting androstenedione to testosterone as well as valuable information for the development of potent enzyme inhibitors...
  57. ncbi 17 beta-hydroxysteroid dehydrogenases--their role in pathophysiology
    P Vihko
    Biocenter Oulu and Research Center for Molecular Endocrinology, University of Oulu, P O Box 5000, FIN 90014, Oulu, Finland
    Mol Cell Endocrinol 215:83-8. 2004
    ....
  58. ncbi Selective inhibition of 17beta-hydroxysteroid dehydrogenase type 1 (17betaHSD1) reduces estrogen responsive cell growth of T47-D breast cancer cells
    Patricia Kruchten
    8 2 Pharmaceutical and Medicinal Chemistry, Saarland University, Saarbrucken, Germany
    J Steroid Biochem Mol Biol 114:200-6. 2009
    ..In conclusion, our findings strongly support suitability of non-steroidal 17betaHSD1-inhibitors for the treatment of estrogen dependent diseases...
  59. ncbi Coenzyme specificity in fungal 17beta-hydroxysteroid dehydrogenase
    Katja Kristan
    Institute of Biochemistry, Medical Faculty, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia
    Mol Cell Endocrinol 241:80-7. 2005
    ....
  60. ncbi 17Beta-hydroxysteroid dehydrogenase type 2: independent prognostic significance and evidence of estrogen protection in female patients with colon cancer
    Olayiwola O Oduwole
    Biocenter Oulu, Research Center for Molecular Endocrinology, WHO Collaborating Centre for Research on Reproductive Health, P O Box 5000, University of Oulu, FIN 90014 Oulu, Finland
    J Steroid Biochem Mol Biol 87:133-40. 2003
    ....
  61. ncbi A concerted, rational design of type 1 17beta-hydroxysteroid dehydrogenase inhibitors: estradiol-adenosine hybrids with high affinity
    Wei Qiu
    Oncology and Molecular Endocrinology Research Center, Laval University Medical Center CHUL and Laval University, Quebec, G1V 4G2, Canada
    FASEB J 16:1829-31. 2002
    ..These results confirm our initial strategy of combining studies of structural biology and enzyme mechanism in the inhibitor design, which may be applied to other steroidogenic enzymes involved in human diseases...
  62. ncbi Unique multifunctional HSD17B4 gene product: 17beta-hydroxysteroid dehydrogenase 4 and D-3-hydroxyacyl-coenzyme A dehydrogenase/hydratase involved in Zellweger syndrome
    Y de Launoit
    Virology Unit, Faculty of Medicine, CP 614, Free University Brussels, 808 Route de Lennik, 1070 Brussels, Belgium
    J Mol Endocrinol 22:227-40. 1999
    ..Mutations in the HSD17B4 lead to a fatal form of Zellweger syndrome...
  63. ncbi Structure of the gene for the human 17beta-hydroxysteroid dehydrogenase type IV
    F Leenders
    UMR 319, CNRS Institut Pasteur de Lille, Institut de Biologie de Lille, 1 rue Calmette, BP 447, 59021 Lille Cedex, France
    Mamm Genome 9:1036-41. 1998
    ..The data presented here will permit sequence analysis of patients with peroxisomal disorders...
  64. ncbi Changes in Leydig cell gene expression during development in the mouse
    P J O'Shaughnessy
    Division of Veterinary Physiology and Pharmacology, Department of Veterinary Preclinical Studies, University of Glasgow Veterinary School, Bearsden Road, Glasgow G61 1QH, United Kingdom
    Biol Reprod 66:966-75. 2002
    ..The developmental pattern of gene expression suggests that three distinct phases of adult Leydig cell differentiation occur...
  65. ncbi Characterization of type 12 17beta-hydroxysteroid dehydrogenase, an isoform of type 3 17beta-hydroxysteroid dehydrogenase responsible for estradiol formation in women
    Van Luu-The
    Oncology and Molecular Endocrinology Research Center, Laval University Medical Center, Quebec, Canada G1V 4G2
    Mol Endocrinol 20:437-43. 2006
    ..Overall, our results strongly suggest that 17beta-HSD12 is the major estrogenic 17beta-HSD responsible for the conversion of E1 to E2 in women, especially in the ovary, the predominant source of estrogens before menopause...
  66. ncbi Localization of type 1 17beta-hydroxysteroid dehydrogenase mRNA and protein in syncytiotrophoblasts and invasive cytotrophoblasts in the human term villi
    M Bonenfant
    Laboratory of Ontogeny and Reproduction, Centre Hospitalier Universitaire de Quebec, Pavillon CHUL, Canada G1V 4G2
    J Endocrinol 165:217-22. 2000
    ..In addition, our results indicate for the first time that CTBs differentiating along the invasive pathway contain type 1 17beta-HSD mRNA...
  67. ncbi Purification, cloning, complementary DNA structure, and predicted amino acid sequence of human estradiol 17 beta-dehydrogenase
    V Luu-The
    MRC Group in Molecular Endocrinology, Research Centre, Laval University Medical Centre, Quebec, Canada
    Ann N Y Acad Sci 595:40-52. 1990
  68. ncbi Molecular characterization of mouse 17 beta-hydroxysteroid dehydrogenase IV
    T Normand
    Unité d Oncologie Moléculaire, CNRS URA 1160, Institut Pasteur de Lille, France
    J Steroid Biochem Mol Biol 55:541-8. 1995
    ..The multitude of enzymes acting at C17 might be necessary for a precise control of hormone levels...
  69. ncbi Localization of 17beta-hydroxysteroid dehydrogenase/17-ketosteroid reductase isoform expression in the developing mouse testis--androstenedione is the major androgen secreted by fetal/neonatal leydig cells
    P J O'Shaughnessy
    Department of Veterinary Preclinical Studies, University of Glasgow Veterinary School, United Kingdom
    Endocrinology 141:2631-7. 2000
    ..Expression of the 17betaHSD/17KSR type 3 isoform (the main reductive isoform in the testis) declines in the seminiferous tubules before puberty but then reappears in the developing adult Leydig cell population...
  70. ncbi Structure and function of 17beta-hydroxysteroid dehydrogenase type 1 and type 2
    P Vihko
    Biocentre Oulu and WHO Collaborating Centre for Research on Reproductive Health, University of Oulu, P O Box 5000, FIN 90014, Oulu, Finland
    Mol Cell Endocrinol 171:71-6. 2001
    ..Deprivation of an estrogen response by using specific 17HSD1 inhibitors is a tempting approach to treat estrogen-dependent breast cancer...
  71. ncbi 17beta-hydroxysteroid dehydrogenase type 1 and 2 expression in the human fetus
    J Takeyama
    Department of Pathology, Tohoku University School of Medicine, Sendai, Miyagi, Japan
    J Clin Endocrinol Metab 85:410-6. 2000
    ..17betaHSD2 in these tissues may be functioning in the prevention of in utero exposure of the fetus to excessive estradiol from the maternal circulation and amniotic fluids...
  72. pmc In vivo and in vitro expression of steroid-converting enzymes in human breast tumours: associations with interleukin-6
    V Speirs
    Department of Medicine, University of Hull, UK
    Br J Cancer 81:690-5. 1999
    ..In conclusion, we propose that these enzymes work in tandem with cytokines thereby providing sufficient quantities of bioactive oestrogen from less active precursors which stimulates tumour growth...
  73. ncbi Cell type-specific expression of 17 beta-hydroxysteroid dehydrogenase type 2 in human placenta and fetal liver
    N Moghrabi
    Cecil H and Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center, Dallas 75235, USA
    J Clin Endocrinol Metab 82:3872-8. 1997
    ..We conclude that the cell type-specific localization of 17 beta HSD type 2 is in accord with the proposed physiological role of the enzyme, namely to protect tissues, in this case the fetus, from bioactive estrogen and androgen...
  74. ncbi Dual regulation of luteal progesterone production by androstenedione during spontaneous and RU486-induced luteolysis in pregnant rats
    C M Telleria
    Laboratorio de Reproduccion y Lactancia, CRICYT CONICET, Mendoza, Argentina
    J Steroid Biochem Mol Biol 55:385-93. 1995
    ....
  75. ncbi Searching for the physiological function of 17beta-hydroxysteroid dehydrogenase from the fungus Cochliobolus lunatus: studies of substrate specificity and expression analysis
    T Lanisnik Rizner
    Institute of Biochemistry, Medical Faculty, University of Ljubljana, Vrazov trg 2, 1000, Ljubljana, Slovenia
    Mol Cell Endocrinol 171:193-8. 2001
    ..Among these two quercetin was more efficient. Expression studies revealed that 17beta-HSDcl is mainly expressed in the stationary phase of growth indicating its possible involvement in secondary metabolism...
  76. ncbi Changes in mRNAs encoding steroidogenic acute regulatory protein, steroidogenic enzymes and receptors for gonadotropins during spermatogenesis in rainbow trout testes
    M Kusakabe
    School of Aquatic and Fishery Sciences, University of Washington, 1140 Boat Street NE, Seattle, Washington 98195 5020, USA
    J Endocrinol 189:541-54. 2006
    ....
  77. ncbi Estrogen inhibits cell proliferation through in situ production in human thymoma
    Hironori Ishibashi
    Department of Pathology, Tohoku University School of Medicine, Japan
    Clin Cancer Res 11:6495-504. 2005
    ..Estrogen sulfotransferase (EST), steroid sulfatase (STS), 17beta-hydroxysteroid dehydrogenase (17beta-HSD), and aromatase are considered to play important roles in hormone metabolism of estrogen-dependent tumors...
  78. ncbi Metabolism of estrogens and androgens by scleractinian corals
    Ann M Tarrant
    Department of Oceanography, University of Hawaii at Manoa, Honolulu, USA
    Comp Biochem Physiol B Biochem Mol Biol 136:473-85. 2003
    ..Considered in total, these observations suggest corals could alter the concentration or form of steroids available to reef organisms...
  79. ncbi Reduction of spermatogenesis and steroidogenesis in mice after fentin and fenbutatin administration
    P Sreedhar Reddy
    Department of Biotechnology, S V University, Tirupati 517502, India
    Toxicol Lett 166:53-9. 2006
    ..The results suggest that fentin and fenbutatin cause impairment of spermatogenesis through the inhibition of testosterone production...
  80. ncbi AKR1C1 and AKR1C3 may determine progesterone and estrogen ratios in endometrial cancer
    Tea Lanisnik Rizner
    Institute of Biochemistry, Medical Faculty, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia
    Mol Cell Endocrinol 248:126-35. 2006
    ..It is suggested that the expression of AKR1C1 and AKR1C3 in endometrial cancer will govern the ratio of P:E2...
  81. pmc Effects of chronic exposure to sodium arsenite on hypothalamo-pituitary-testicular activities in adult rats: possible an estrogenic mode of action
    Kuladip Jana
    Department of Veterinary Surgery and Radiology, West Bengal University of Animal and Fishery Sciences, 37 and 68, K B Sarani, Calcutta 700 037, West Bengal, India
    Reprod Biol Endocrinol 4:9. 2006
    ..In this context, we evaluated the mode of action of chronic oral exposure of sodium arsenite on hypothalamo-pituitary- testicular activities in mature male albino rats...
  82. ncbi Expression of functional aromatase in the epididymis: role of androgens and LH in modulation of expression and activity
    D Shayu
    Department of Biochemistry, Indian Institute of Science, Bangalore 560012, India
    Mol Cell Endocrinol 249:40-50. 2006
    ..Together our results highlight the presence of a functional aromatase in the epididymis that is subject to regulation by LH and androgens...
  83. ncbi Sex steroid concentrations and localization of steroidogenic enzyme expression in free-ranging female northern fur seals (Callorhinus ursinus)
    Patience Browne
    Population, Health and Reproduction, University of California, Davis, 1114 Tupper Hall, 95616, USA
    Gen Comp Endocrinol 147:175-83. 2006
    ..These data suggest androgens may play a substantial regulatory role in the embryonic delay of northern fur seals...
  84. ncbi Steroid metabolism in breast cancer
    P A Foster
    Endocrinology and Metabolic Medicine and Sterix Ltd, Faculty of Medicine, Imperial College London, St Mary s Hospital, London, W2 1NY, UK
    Minerva Endocrinol 33:27-37. 2008
    ..However, such endocrine therapy that is currently being explored has shown promising results for patients with hormone-dependent breast cancer...
  85. ncbi Radiation exposure impairs luteinizing hormone signal transduction and steroidogenesis in cultured human leydig cells
    Ramadoss Sivakumar
    Department of Endocrinology, Dr ALM PG Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai 600 113, Tamil Nadu, India
    Toxicol Sci 91:550-6. 2006
    ..Decreased level of LH receptors following higher doses of radiation exposure is not coupled with impaired expression of its mRNA...
  86. ncbi Expression of steroidogenic enzymes and synthesis of sex steroid hormones from DHEA in skeletal muscle of rats
    Katsuji Aizawa
    Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tennodai 1 1 1, Tsukuba, Ibaraki 305 8577, Japan
    Am J Physiol Endocrinol Metab 292:E577-84. 2007
    ..These findings are novel and important in that they provide the first evidence showing that skeletal muscles are capable of locally synthesizing sex steroid hormones from circulating DHEA or testosterone...
  87. ncbi Variants in estrogen biosynthesis genes, sex steroid hormone levels, and endometrial cancer: a HuGE review
    Sara H Olson
    Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Am J Epidemiol 165:235-45. 2007
    ..Larger studies or combined studies that allow for investigation of gene-gene and gene-environment interactions are warranted...
  88. ncbi Protective effect of selenium on nicotine-induced testicular toxicity in rats
    P Seema
    Department of Biochemistry, University of Kerala, Kariavattom, Trivandrum 695581, India
    Biol Trace Elem Res 120:212-8. 2007
    ..Nondetectable levels of nicotine were present in the co-administered group. This indicates altered metabolism of nicotine when administered along with selenium...
  89. ncbi An investigation of the effects of methylmercury in rats fed different dietary fats and proteins: testicular steroidogenic enzymes and serum testosterone levels
    Mark J McVey
    Toxicology Research Division, Health Products and Foods Branch, Food Directorate, Health Canada, Sir Fredrick G Banting Research Centre, 2202D1 Tunney s Pasture, Ottawa, ON, Canada K1A 0L2
    Food Chem Toxicol 46:270-9. 2008
    ..In conclusion, these studies show that different lipid diets can alter the toxic effects of MeHg on male rat steroidogenesis in terms of serum testosterone and steroidogenic enzyme activities...
  90. ncbi Sex differences in steroidogenesis in skeletal muscle following a single bout of exercise in rats
    Katsuji Aizawa
    Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
    J Appl Physiol (1985) 104:67-74. 2008
    ..The acute exercise-induced alteration of steroidogenic enzymes may enhance the local steroidogenesis in the skeletal muscle in both sexes...
  91. ncbi Effects of a 3beta-hydroxysteroid dehydrogenase inhibitor, trilostane, on the fathead minnow reproductive axis
    Daniel L Villeneuve
    Mid Continent Ecology Division, National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Office of Research and Development, 6201 Congdon Boulevard, Duluth, Minnesota 55804, USA
    Toxicol Sci 104:113-23. 2008
    ....
  92. ncbi Inhibitory effect of tributyltin on expression of steroidogenic enzymes in mouse testis
    Suel Kee Kim
    Division of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, Republic of Korea
    Int J Toxicol 27:175-82. 2008
    ..These adverse effects of TBT would cause serious defects in testicular development and function...
  93. ncbi Gene expression of 3beta-hydroxysteroid dehydrogenase and 17beta-hydroxysteroid dehydrogenase in relation to androstenone, testosterone, and estrone sulphate in gonadally intact male and castrated pigs
    G Chen
    Department of Food Science, Swedish University of Agricultural Sciences, PO Box 7051, SE 750 07 Uppsala, Sweden
    J Anim Sci 85:2457-63. 2007
    ..Another strong correlation was found between 3betaHSD and 17betaHSD gene expression in liver of the gonadally intact male pigs (r = 0.86; P < 0.01), possibly reflecting similar regulation mechanisms of these genes...
  94. ncbi Modulation of antioxidant defense system by the environmental fungicide carbendazim in Leydig cells of rats
    Sivasankaran Rajeswary
    Department of Zoology, Kanchi Mamunivar Centre for Post Graduate Studies, Tagore Arts College Campus, Lawspet, Pondicherry, India
    Reprod Toxicol 24:371-80. 2007
    ..Thus, the present study suggests that chronic low dose treatment of MBC is capable of inducing reproductive toxicity through increased oxidative stress, but is transient and reversible upon withdrawal of treatment...
  95. ncbi 17beta-estradiol synthesis in the adult male rat retina
    C Cascio
    Istituto di Biomedicina e Immunologia Molecolare, IBIM CNR, Via Ugo La Malfa, 153, 90146 Palermo, Italy
    Exp Eye Res 85:166-72. 2007
    ....
  96. ncbi Presence of sex steroids and cytochrome P450 genes in amphioxus
    Takanobu Mizuta
    Center for Advanced Marine Research, Ocean Research Institute, University of Tokyo, Nakano, Tokyo 164 8639, Japan
    Endocrinology 148:3554-65. 2007
    ..This study is the first evidence to suggest the presence of CYP enzymes in sex steroid production in invertebrates...
  97. ncbi Dietary lipids modify redox homeostasis and steroidogenic status in rat testis
    Graciela E Hurtado de Catalfo
    Instituto de Investigaciones Bioquimicas de La Plata, CONICET UNLP, Catedra de Bioquimica, Facultad de Ciencias Medicas, Universidad Nacional de La Plata, La Plata, Argentina
    Nutrition 24:717-26. 2008
    ..The present study explored the effect of dietary oils on lipid composition, antioxidant status, and the activity of the main steroidogenic enzymes in the testis...
  98. ncbi Sterilization of male stray dogs with a single intratesticular injection of calcium chloride: a dose-dependent study
    Kuladip Jana
    Department of Veterinary Surgery and Radiology, West Bengal University of Animal and Fishery Sciences, Kolkata, West Bengal 700 078, India
    Contraception 75:390-400. 2007
    ..To study a method of chemical sterilization and its efficacy in adult male stray dogs...
  99. ncbi Alterations in gene expression and testosterone synthesis in the testes of male rats exposed to perfluorododecanoic acid
    Zhimin Shi
    Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100080, China
    Toxicol Sci 98:206-15. 2007
    ..Our results demonstrate that PFDoA affects the reproduction function of male rats via alterations in steroidogenesis genes, testosterone levels, and testes ultrastructure...
  100. ncbi Protection of testicular dysfunctions by MTEC, a formulated herbal drug, in streptozotocin induced diabetic rat
    Chhanda Mallick
    Reproductive Endocrinology and Family Welfare Research Unit, Department of Human Physiology with Community Health, Vidyasagar University, Midnapore, West Bengal, India
    Biol Pharm Bull 30:84-90. 2007
    ..The results support the validity of this herbal drug for the management of testicular disorders noted in diabetic state...
  101. ncbi Caenorhabditis elegans LET-767 is able to metabolize androgens and estrogens and likely shares common ancestor with human types 3 and 12 17beta-hydroxysteroid dehydrogenases
    Serge Desnoyers
    Pediatrics Research Unit, Laval University Medical Center CHUL and Laval University, 2705 Laurier Boulevard, Quebec, G1V 4G2 Canada
    J Endocrinol 195:271-9. 2007
    ..The high conservation of the active site and amino acids responsible for enzymatic activity and substrate selectivity strongly suggests that LET-767 shares a common ancestor with human 17beta-HSD3 and 12...

Research Grants23

  1. ESTROGEN BIOSYNTHESIS AND UTERINE LEIOMYOMATA
    Serdar Bulun; Fiscal Year: 2007
    ..We predict that these studies will establish the critical role of P450arom in uterine leiomyomata and lead to identification of novel therapeutic targets. ..
  2. SWAN Sleep Study II - Chicago (Rush) Site
    Howard Kravitz; Fiscal Year: 2008
    ..The results can inform primary prevention of adverse health outcomes due to the menopause-related sleep disturbances. ..
  3. Breast Cancer-Proximal Stroma Interaction & Aromatase
    Serdar E Bulun; Fiscal Year: 2010
    ..noncarrier controls. Proposed studies may lead to new pilot trials of treatment and prevention using p38/JNK inhibitors in BRCA1 mutation carriers. ..
  4. MECHANISMS OF ESTROGEN BIOSYNTHESIS IN ENDOMETRIOSIS
    Serdar Bulun; Fiscal Year: 2008
    ..Investigation of local feedback mechanisms responsible for interactions between estrogen biosynthesis, tissue growth, and inflammation will lead to the rational design of novel drug treatments. ..
  5. A Comprehensive Analysis of Genetic Variation in DNA Repair Genes in Relation to
    Christopher Haiman; Fiscal Year: 2007
    ..The ability to accurately identify high-risk sub-groups may have profound implications on endometrial cancer prevention as well as advance research aimed at targeted drug development. [unreadable] [unreadable] [unreadable]..
  6. Molecular Mechanisms of Multistage Carcinogenesis
    TREVOR PENNING; Fiscal Year: 2006
    ..By studying the discrete molecular events responsible for the causation of cancer this Program may lead to the early prevention and intervention of this disease. ..
  7. DIETARY AND GENETIC DETERMINANTS OF MAMMOGRAPHIC DENSITY
    Anna Wu; Fiscal Year: 2008
    ..abstract_text> ..
  8. Structure of Microsomal Enzymes in Estrogen Biosynthesis
    Debashis Ghosh; Fiscal Year: 2005
    ....
  9. Fine-mapping of 8q24 and Loci Identified in Genome-Wide Studies for Breast & Colo
    CHRISTOPHER ALAN HAIMAN; Fiscal Year: 2010
    ..We expect findings from this work to guide the development of future preventive, early detection and prognostic strategies ..
  10. Functional Status and the Menopause Transition
    MaryFran R Sowers; Fiscal Year: 2010
    ..Among the elderly, older women live longer, develop more chronic disease and experience more prolonged and severe disability than older men. ..
  11. Symposium on Aldo-Keto Reductases & Toxicant Metabolism
    TREVOR PENNING; Fiscal Year: 2002
    ..abstract_text> ..
  12. Sertoli Cell Mediated Engulfment of Apoptotic Germ Cells
    Kodi S Ravichandran; Fiscal Year: 2010
    ..abstract_text> ..
  13. STRUCTURE/FUNCTION OF C1 CHANNEL GENES IN CILIARY BODIES
    Miguel Coca Prados; Fiscal Year: 2001
    ..4) To determine the organization of the human pICln and ClC-3 genes at their 5' flanking region. The goal in these studies will be to obtain information from genomic clones of the putative regulatory elements present in these genes. ..
  14. Estrogen Receptor-related Receptor Action in Zebrafish
    Ann Tarrant; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  15. REGULATION OF PRIMATE ENDOMETRIAL RESPONSE
    William Okulicz; Fiscal Year: 2003
    ..The studies designed herein can potentially provide important insights into the genes that are involved in disorders of female fertility, endometrial hyperplasia, and reproductive tract cancer. ..
  16. SWAN Sleep Study II - Michigan Center
    MaryFran Sowers; Fiscal Year: 2008
    ..The results can inform primary prevention of adverse health outcomes due to the menopause-related sleep disturbances. [unreadable] [unreadable] [unreadable]..
  17. Estrogen, Metabolism, Menopause, and Health Outcomes
    MaryFran Sowers; Fiscal Year: 2006
    ..This is a unique opportunity to prospectively integrate lifestyle elements with measures of hormone metabolism pathways into a comprehensive examination of multiple human health effects. ..
  18. Impact of Endocrine Disrupter on Primate Spermatogenesis
    Suresh Ramaswamy; Fiscal Year: 2003
    ..Moreover, this study will also establish the prepubertal primate testicular clamp preparation as a superior model for the general examination of the effects of EDs in man. ..
  19. DIFFERENTIAL GENE EXPRESSION IN CILIARY EPITHELIUM
    Miguel Coca Prados; Fiscal Year: 2005
    ..To determine any light-sensing responses in intact and cultured ciliary epithelial cells, by studying the cGMP-gated channel under light and dark conditions. ..
  20. Change in Bone, Arthritis, Function: Hormones & Obesity
    MaryFran Sowers; Fiscal Year: 2009
    ....
  21. ESTROGEN, DIET, GENETICS AND ENDOMETRIAL CANCER
    Sara Olson; Fiscal Year: 2005
    ..This study will provide data on genetic susceptibility in endometrial cancer in conjunction with established risk factors, as well as the first epidemiologic data on the more lethal serous and clear cell tumors. ..
  22. Regulation of Testosterone Synthesis in TheCA cells
    Kenan Qin; Fiscal Year: 2007
    ..This award will dedicate these five years to rigorous scientific, technical, and intellectual training such that Dr. Qin can ultimately develop into an independently productive physician-scientist. ..