oxidoreductases

Summary

Summary: The class of all enzymes catalyzing oxidoreduction reactions. The substrate that is oxidized is regarded as a hydrogen donor. The systematic name is based on donor:acceptor oxidoreductase. The recommended name will be dehydrogenase, wherever this is possible; as an alternative, reductase can be used. Oxidase is only used in cases where O2 is the acceptor. (Enzyme Nomenclature, 1992, p9)

Top Publications

  1. doi Ero1α regulates Ca(2+) fluxes at the endoplasmic reticulum-mitochondria interface (MAM)
    Tiziana Anelli
    Universita Vita Salute San Raffaele, Milano, Italy
    Antioxid Redox Signal 16:1077-87. 2012
  2. doi The influence of soil pH on the diversity, abundance and transcriptional activity of ammonia oxidizing archaea and bacteria
    Graeme W Nicol
    Institute of Biological and Environmental Science, University of Aberdeen, Cruickshank Building, Aberdeen, UK
    Environ Microbiol 10:2966-78. 2008
  3. ncbi Novel genes for nitrite reductase and Amo-related proteins indicate a role of uncultivated mesophilic crenarchaeota in nitrogen cycling
    Alexander H Treusch
    University of Bergen, Department of Biology, Jahnebakken 5, N 5020 Bergen, Norway
    Environ Microbiol 7:1985-95. 2005
  4. pmc Cytokinin-deficient transgenic Arabidopsis plants show multiple developmental alterations indicating opposite functions of cytokinins in the regulation of shoot and root meristem activity
    Tomáš Werner
    Institute of Biology Applied Genetics, Freie Universitat Berlin, 14195 Berlin, Germany
    Plant Cell 15:2532-50. 2003
  5. doi The emerging role for bacteria in lignin degradation and bio-product formation
    Timothy D H Bugg
    Department of Chemistry, University of Warwick, Coventry CV4 7AL, UK
    Curr Opin Biotechnol 22:394-400. 2011
  6. pmc Oxidative protein folding in eukaryotes: mechanisms and consequences
    Benjamin P Tu
    Howard Hughes Medical Institute, Department of Cellular and Molecular Pharmacology, University of California, San Francisco, 94143, USA
    J Cell Biol 164:341-6. 2004
  7. doi Mechanisms and implications of reactive oxygen species generation during the unfolded protein response: roles of endoplasmic reticulum oxidoreductases, mitochondrial electron transport, and NADPH oxidase
    Celio X C Santos
    Vascular Biology Laboratory, Heart Institute InCor, University of Sao Paulo School of Medicine, CEP 05403 000, Sao Paulo, Brazil
    Antioxid Redox Signal 11:2409-27. 2009
  8. doi Growth, activity and temperature responses of ammonia-oxidizing archaea and bacteria in soil microcosms
    Maria Tourna
    School of Biological Sciences, University of Aberdeen, Cruickshank Building, St Machar Drive, Aberdeen AB24 3UU, UK
    Environ Microbiol 10:1357-64. 2008
  9. pmc Arabidopsis mutants define a central role for the xanthophyll cycle in the regulation of photosynthetic energy conversion
    K K Niyogi
    Carnegie Institution of Washington, Department of Plant Biology, 260 Panama Street, Stanford, California 94305, USA
    Plant Cell 10:1121-34. 1998
  10. ncbi Ceramide synthases: roles in cell physiology and signaling
    Johnny Stiban
    Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel
    Adv Exp Med Biol 688:60-71. 2010

Research Grants

  1. Pyruvate Dehydrogenase kinase as Therapeutic Target for Hepatic Steatosis, Obesit
    Robert A Harris; Fiscal Year: 2012
  2. Anti-tumor properties of curcumin in oral cancers: role of thioredoxin reductase
    STEPHEN WILLIAM TUTTLE; Fiscal Year: 2010
  3. Paolo Fanti; Fiscal Year: 2014
  4. Iron-mediated vascular disease in sickle cell disease.
    John C Wood; Fiscal Year: 2010
  5. Angiotensin Adrenergic Interactions in the Kidney
    Roland C Blantz; Fiscal Year: 2013
  6. Qinghua Sun; Fiscal Year: 2015
  7. ANTHONY JOHN KANAI; Fiscal Year: 2016
  8. Pathogenesis and Treatment of Liver Disease in Transaldolase Deficiency
    Andras Perl; Fiscal Year: 2013
  9. ENEIQUE A MESRI; Fiscal Year: 2016
  10. Inhibition of human neutrophil function by Francisella tularensis
    Lee Ann H Allen; Fiscal Year: 2012

Detail Information

Publications437 found, 100 shown here

  1. doi Ero1α regulates Ca(2+) fluxes at the endoplasmic reticulum-mitochondria interface (MAM)
    Tiziana Anelli
    Universita Vita Salute San Raffaele, Milano, Italy
    Antioxid Redox Signal 16:1077-87. 2012
    ..How these multiple functions are integrated with one another in living cells remains unclear...
  2. doi The influence of soil pH on the diversity, abundance and transcriptional activity of ammonia oxidizing archaea and bacteria
    Graeme W Nicol
    Institute of Biological and Environmental Science, University of Aberdeen, Cruickshank Building, Aberdeen, UK
    Environ Microbiol 10:2966-78. 2008
    ..They also suggest that both groups of ammonia oxidizers have distinct physiological characteristics and ecological niches, with consequences for nitrification in acid soils...
  3. ncbi Novel genes for nitrite reductase and Amo-related proteins indicate a role of uncultivated mesophilic crenarchaeota in nitrogen cycling
    Alexander H Treusch
    University of Bergen, Department of Biology, Jahnebakken 5, N 5020 Bergen, Norway
    Environ Microbiol 7:1985-95. 2005
    ..Taken together, our findings suggest that mesophilic terrestrial and marine crenarchaeota might be capable of ammonia oxidation under aerobic and potentially also under anaerobic conditions...
  4. pmc Cytokinin-deficient transgenic Arabidopsis plants show multiple developmental alterations indicating opposite functions of cytokinins in the regulation of shoot and root meristem activity
    Tomáš Werner
    Institute of Biology Applied Genetics, Freie Universitat Berlin, 14195 Berlin, Germany
    Plant Cell 15:2532-50. 2003
    ....
  5. doi The emerging role for bacteria in lignin degradation and bio-product formation
    Timothy D H Bugg
    Department of Chemistry, University of Warwick, Coventry CV4 7AL, UK
    Curr Opin Biotechnol 22:394-400. 2011
    ..If biocatalytic routes for lignin breakdown could be developed, then lignin represents a potentially rich source of renewable aromatic chemicals...
  6. pmc Oxidative protein folding in eukaryotes: mechanisms and consequences
    Benjamin P Tu
    Howard Hughes Medical Institute, Department of Cellular and Molecular Pharmacology, University of California, San Francisco, 94143, USA
    J Cell Biol 164:341-6. 2004
    ..How Ero1p distinguishes between the many different PDI-related proteins and how the cell minimizes the effects of oxidative damage from Ero1 remain important open questions...
  7. doi Mechanisms and implications of reactive oxygen species generation during the unfolded protein response: roles of endoplasmic reticulum oxidoreductases, mitochondrial electron transport, and NADPH oxidase
    Celio X C Santos
    Vascular Biology Laboratory, Heart Institute InCor, University of Sao Paulo School of Medicine, CEP 05403 000, Sao Paulo, Brazil
    Antioxid Redox Signal 11:2409-27. 2009
    ..mechanisms of ROS generation during UPR include: (a) Multiple thiol-disulfide exchanges involving ER oxidoreductases including flavooxidase Ero1 and protein disulfide isomerase (PDI); (b) Mitochondrial electron transport; (c) ..
  8. doi Growth, activity and temperature responses of ammonia-oxidizing archaea and bacteria in soil microcosms
    Maria Tourna
    School of Biological Sciences, University of Aberdeen, Cruickshank Building, St Machar Drive, Aberdeen AB24 3UU, UK
    Environ Microbiol 10:1357-64. 2008
    ..The findings suggest a role for crenarchaea in soil nitrification and that further information is required on their biogeography...
  9. pmc Arabidopsis mutants define a central role for the xanthophyll cycle in the regulation of photosynthetic energy conversion
    K K Niyogi
    Carnegie Institution of Washington, Department of Plant Biology, 260 Panama Street, Stanford, California 94305, USA
    Plant Cell 10:1121-34. 1998
    ....
  10. ncbi Ceramide synthases: roles in cell physiology and signaling
    Johnny Stiban
    Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel
    Adv Exp Med Biol 688:60-71. 2010
    ..Finally, we discuss the putative roles of CerS and the ceramide derived from the CerS, in signaling pathways and in development of disease...
  11. doi Relative abundance and diversity of ammonia-oxidizing archaea and bacteria in the San Francisco Bay estuary
    Annika C Mosier
    Department of Environmental Earth System Science, Stanford University, Stanford, CA 94305, USA
    Environ Microbiol 10:3002-16. 2008
    ..Overall, this study significantly enhances our understanding of estuarine ammonia-oxidizing microbial communities and highlights the environmental conditions and niches under which different AOA and beta-AOB phylotypes may thrive...
  12. pmc Coordinating assembly and export of complex bacterial proteins
    Rachael L Jack
    School of Biological Sciences, University of East Anglia, Norwich, UK
    EMBO J 23:3962-72. 2004
    ..It is proposed that some Tat signal peptides operate in tandem with cognate binding chaperones to orchestrate the assembly and transport of complex enzymes...
  13. pmc Medium- and short-chain dehydrogenase/reductase gene and protein families : the SDR superfamily: functional and structural diversity within a family of metabolic and regulatory enzymes
    K L Kavanagh
    Structural Genomics Consortium, University of Oxford, United Kingdom
    Cell Mol Life Sci 65:3895-906. 2008
    Short-chain dehydrogenases/reductases (SDRs) constitute a large family of NAD(P)(H)-dependent oxidoreductases, sharing sequence motifs and displaying similar mechanisms...
  14. doi Activity, abundance and diversity of nitrifying archaea and bacteria in the central California Current
    Alyson E Santoro
    Department of Marine Chemistry and Geochemistry, Woods Hole Oceanographic Institution, Woods Hole, MA 02543, USA
    Environ Microbiol 12:1989-2006. 2010
    ..Using an isotope mass balance model, we calculate that nitrification could produce between 0.45 and 2.93 micromol m(-2) day(-1) N(2)O in the central California Current, or approximately 1.5-4 times the local N(2)O flux from deep water...
  15. pmc Proanthocyanidin synthesis and expression of genes encoding leucoanthocyanidin reductase and anthocyanidin reductase in developing grape berries and grapevine leaves
    Jochen Bogs
    Commonwealth Scientific and Industrial Research Organization, Plant Industry, Horticulture Unit, Glen Osmond, South Australia
    Plant Physiol 139:652-63. 2005
    ..Both ANR and LAR contribute to PA synthesis in fruit, and the tissue and temporal-specific regulation of the genes encoding ANR and LAR determines PA accumulation and composition during grape berry development...
  16. pmc Evolutionary origins and functions of the carotenoid biosynthetic pathway in marine diatoms
    Sacha Coesel
    Cell Signalling Laboratory, Stazione Zoologica Anton Dohrn, Villa Comunale, Naples, Italy
    PLoS ONE 3:e2896. 2008
    ....
  17. doi Ammonia-oxidizing archaea: important players in paddy rhizosphere soil?
    Xue Ping Chen
    Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China
    Environ Microbiol 10:1978-87. 2008
    ..These results show that AOA is dominant in the rhizosphere paddy soil in this study, and we assume that AOA were influenced more by exudation from rice root (e.g. oxygen, carbon dioxide) than AOB...
  18. ncbi Improvement in the RFLP procedure for studying the diversity of nifH genes in communities of nitrogen fixers in soil
    F Poly
    Laboratoire d Ecologie Microbienne, UMR CNRS 5557, UCB Lyon 1, Villeurbanne, France
    Res Microbiol 152:95-103. 2001
    ..Pure strain profiles could not be recognized in the nifH soil patterns. Using the simple procedure described, it was shown that the structure of nitrogen fixers in soil was influenced by soil functioning...
  19. pmc Functional in vitro analysis of the ERO1 protein and protein-disulfide isomerase pathway
    Kazutaka Araki
    Department of Molecular and Cellular Biology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606 8507, Japan
    J Biol Chem 286:32705-12. 2011
    ..the ERO1-PDI pathway was demonstrated by functional in vitro complementation assays using yeast and mammalian oxidoreductases. Finally, the results provide experimental evidence for the intramolecular electron transfer from the a ..
  20. pmc The role of glutathione in disulphide bond formation and endoplasmic-reticulum-generated oxidative stress
    Seema Chakravarthi
    The Faculty of Life Sciences, University of Manchester, The Michael Smith Building, Oxford Road, Manchester M13 9PT, UK
    EMBO Rep 7:271-5. 2006
    ..In this review, we discuss the arguments for and against a role for glutathione in facilitating disulphide-bond formation and consider its role in protecting the cell from endoplasmic-reticulum-generated oxidative stress...
  21. pmc Seasonal changes of freshwater ammonia-oxidizing archaeal assemblages and nitrogen species in oligotrophic alpine lakes
    Jean Christophe Auguet
    Centro de Estudios Avanzados de Blanes, CEAB CSIC, Accés Cala Sant Francesc 14, E 17300, Blanes, Spain
    Appl Environ Microbiol 77:1937-45. 2011
    ..This suggests that different AOA ecotypes are adapted to different temporal ecological niches in these lakes...
  22. doi ArxA, a new clade of arsenite oxidase within the DMSO reductase family of molybdenum oxidoreductases
    Kamrun Zargar
    Departments of Microbiology and Environmental Toxicology Biomolecular Engineering, University of California Santa Cruz, CA 95064, USA
    Environ Microbiol 14:1635-45. 2012
    ..for arsenotrophy belong to distinct clades within the DMSO reductase family of molybdenum-containing oxidoreductases: specifically arsenate respiratory reductase, ArrA, and arsenite oxidase, AioA (formerly referred to as AroA ..
  23. pmc Ceramide biogenesis is required for radiation-induced apoptosis in the germ line of C. elegans
    Xinzhu Deng
    Laboratory of Signal Transduction, Memorial Sloan Kettering Cancer Center MSKCC, New York, NY 10021, USA
    Science 322:110-5. 2008
    ....
  24. doi FOLy: an integrated database for the classification and functional annotation of fungal oxidoreductases potentially involved in the degradation of lignin and related aromatic compounds
    Anthony Levasseur
    UMR 1163 INRA de Biotechnologie des Champignons Filamenteux, IFR86 BAIM, Universités de Provence et de la Méditerranée, ESIL, 163 Avenue de Luminy, Case Postale 925, 13288 Marseille Cedex 09, France
    Fungal Genet Biol 45:638-45. 2008
    ..Genomic comparison of the oxidoreductases of these fungi revealed significant differences in the putative enzyme arsenals...
  25. ncbi Nitrogenase gene diversity and microbial community structure: a cross-system comparison
    Jonathan P Zehr
    Department of Ocean Sciences, University of California, Santa Cruz, Santa Cruz, CA 95064, USA
    Environ Microbiol 5:539-54. 2003
    ..The broad analysis of nitrogenase genes provides a basis for developing molecular assays and bioinformatics approaches for the study of nitrogen fixation in the environment...
  26. ncbi Archaea predominate among ammonia-oxidizing prokaryotes in soils
    S Leininger
    Department of Biology, University of Bergen, Jahnebakken 5, N 5020 Bergen, Norway
    Nature 442:806-9. 2006
    ..Our results indicate that crenarchaeota may be the most abundant ammonia-oxidizing organisms in soil ecosystems on Earth...
  27. ncbi GMC oxidoreductases. A newly defined family of homologous proteins with diverse catalytic activities
    D R Cavener
    Department of Molecular Biology, Vanderbilt University, Nashville, TN 37235
    J Mol Biol 223:811-4. 1992
    ..that these four diverse flavoproteins are homologous, defining a new family of proteins named the GMC oxidoreductases. These enzymes contain a canonical ADP-binding beta alpha beta-fold close to their amino termini as found in ..
  28. doi Diversity of ammonium-oxidizing bacteria in a granular sludge anaerobic ammonium-oxidizing (anammox) reactor
    Zhe Xue Quan
    Department of Microbiology and Microbial Engineering, School of Life Sciences, Fudan University, Shanghai, China
    Environ Microbiol 10:3130-9. 2008
    ..The partial sequence of hydrazine-oxidizing enzyme (hzo) of dominant AnAOB was also identified using new designed primers. Based on this analysis, we propose to tentatively name this new AnAOB Candidatus'Jettenia asiatica'...
  29. pmc Low reduction potential of Ero1alpha regulatory disulphides ensures tight control of substrate oxidation
    Karl M Baker
    Faculty of Life Sciences, University of Manchester, Manchester, UK
    EMBO J 27:2988-97. 2008
    ....
  30. doi Environmental detection of octahaem cytochrome c hydroxylamine/hydrazine oxidoreductase genes of aerobic and anaerobic ammonium-oxidizing bacteria
    Markus C Schmid
    Department of Microbiology, IWWR, Radboud University Nijmegen, Nijmegen, The Netherlands
    Environ Microbiol 10:3140-9. 2008
    ..We propose that OCC protein-encoding genes are suitable targets for molecular ecological studies on both aerobic and anaerobic ammonium-oxidizing bacteria...
  31. pmc Crystal structures of human Ero1α reveal the mechanisms of regulated and targeted oxidation of PDI
    Kenji Inaba
    Division of Protein Chemistry, Post Genome Science Center, Medical Institute of Bioregulation, Kyushu University, Maidashi, Higashi ku, Fukuoka, Japan
    EMBO J 29:3330-43. 2010
    ..Ero1α activity ensure that not all PDIs are oxidized, its specificity towards PDI could allow other resident oxidoreductases to remain reduced and competent to carry out isomerization and reduction of protein substrates...
  32. ncbi Dual oxidases represent novel hydrogen peroxide sources supporting mucosal surface host defense
    Miklos Geiszt
    Department of Physiology, Semmelweis University, Faculty of Medicine, Bethesda, Maryland, USA
    FASEB J 17:1502-4. 2003
    ..Our observations suggest that Duox1 and Duox2 are novel H2O2 sources that can support LPO-mediated antimicrobial defense mechanisms on mucosal surfaces...
  33. ncbi Identification of a protein required for disulfide bond formation in vivo
    J C Bardwell
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115
    Cell 67:581-9. 1991
    ..protein containing the sequence cys-pro-his-cys, which resembles the active sites of certain disulfide oxidoreductases. The purified DsbA protein is capable of reducing the disulfide bonds of insulin, an activity that it shares ..
  34. ncbi Short-chain dehydrogenases/reductases (SDR)
    H Jornvall
    Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
    Biochemistry 34:6003-13. 1995
    ..Short-chain dehydrogenases illustrate the value of comparisons and diversified research in generating unexpected discoveries...
  35. ncbi Proanthocyanidin biosynthesis in plants. Purification of legume leucoanthocyanidin reductase and molecular cloning of its cDNA
    Gregory J Tanner
    CSIRO Plant Industry, GPO Box 1600, Canberra, Australian Capital Territory 2601, Australia
    J Biol Chem 278:31647-56. 2003
    ..This may be because Arabidopsis seems to produce only an epicatechin, rather than a dual catechin/epicatechin-based PA similar to many other plants...
  36. pmc Pathways of carbon assimilation and ammonia oxidation suggested by environmental genomic analyses of marine Crenarchaeota
    Steven J Hallam
    Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
    PLoS Biol 4:e95. 2006
    ..These findings further substantiate the likely global metabolic importance of Crenarchaeota with respect to key steps in the biogeochemical transformation of carbon and nitrogen in marine ecosystems...
  37. ncbi Arsenic and selenium in microbial metabolism
    John F Stolz
    Department of Biological Sciences, Duquesne University, Pittsburgh, Pennsylvania 15282, USA
    Annu Rev Microbiol 60:107-30. 2006
    ..This review highlights recent advances in ecology, biochemistry, and molecular biology and provides a prelude to the impact of genomics studies...
  38. ncbi When do Lasses (longevity assurance genes) become CerS (ceramide synthases)?: Insights into the regulation of ceramide synthesis
    Yael Pewzner-Jung
    Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel
    J Biol Chem 281:25001-5. 2006
  39. pmc GILT is a critical host factor for Listeria monocytogenes infection
    Reshma Singh
    Department of Immunobiology, Yale University School of Medicine, 300 Cedar Street, New Haven, Connecticut 06250 8011, USA
    Nature 455:1244-7. 2008
    ..In addition, purified GILT activates recombinant LLO, facilitating membrane permeabilization and red blood cell lysis. The data show that GILT is a critical host factor that facilitates L. monocytogenes infection...
  40. doi Environmental factors shaping the ecological niches of ammonia-oxidizing archaea
    Tuba H Erguder
    Laboratory of Microbial Ecology and Technology LabMET, Gent University, Gent, Belgium
    FEMS Microbiol Rev 33:855-69. 2009
    ..It is proposed that the AOA might be important actors within the nitrogen cycle in low-nutrient, low-pH, and sulfide-containing environments...
  41. doi A comparison of primer sets for detecting 16S rRNA and hydrazine oxidoreductase genes of anaerobic ammonium-oxidizing bacteria in marine sediments
    Meng Li
    Division of Microbiology, School of Biological Sciences, The University of Hong Kong, Pokfulam Road, Hong Kong, SAR, People s Republic of China
    Appl Microbiol Biotechnol 86:781-90. 2010
    ..Results indicated a broad distribution of anammox bacteria with high niche-specific community structure within each marine ecosystem...
  42. ncbi Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance
    William L Holland
    Division of Endocrinology, Metabolism, and Diabetes, Department of Internal Medicine, University of Utah, Salt Lake City, UT 84132, USA
    Cell Metab 5:167-79. 2007
    ..Second, they identify enzymes required for ceramide synthesis as therapeutic targets for combating insulin resistance caused by nutrient excess or glucocorticoid therapy...
  43. doi Major gradients in putatively nitrifying and non-nitrifying Archaea in the deep North Atlantic
    Hélène Agogué
    Department of Biological Oceanography, Royal Netherlands Institute for Sea Research Royal NIOZ, PO Box 59, 1790 AB Den Burg, Texel, The Netherlands
    Nature 456:788-91. 2008
    ....
  44. ncbi Thioredoxin and glutaredoxin systems
    A Holmgren
    Department of Physiological Chemistry, Karolinska Institute, Stockholm, Sweden
    J Biol Chem 264:13963-6. 1989
  45. ncbi Divergent evolution of enzymatic function: mechanistically diverse superfamilies and functionally distinct suprafamilies
    J A Gerlt
    Departments of Biochemistry and Chemistry, University of Illinois, Urbana, Illinois 61801, USA
    Annu Rev Biochem 70:209-46. 2001
    ....
  46. ncbi The mcrA gene as an alternative to 16S rRNA in the phylogenetic analysis of methanogen populations in landfill
    Philip E Luton
    Centre for Applied Microbiology and Research, Porton Down, Salisbury, Wiltshire SP4 0JG, UK
    Microbiology 148:3521-30. 2002
    ..Analysis revealed a far greater diversity in the methanogen population within landfill material than has been seen previously...
  47. ncbi Biodegradation of lignocellulosics: microbial, chemical, and enzymatic aspects of the fungal attack of lignin
    Angel T Martinez
    Biological Research Center, CSIC, Madrid, Spain
    Int Microbiol 8:195-204. 2005
    ..degradation and modification of the lignin polymer are reviewed, as are the different oxidative enzymes (oxidoreductases) involved in lignin degradation...
  48. pmc Understanding how the distal environment directs reactivity in chlorite dismutase: spectroscopy and reactivity of Arg183 mutants
    Béatrice Blanc
    Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, United States
    Biochemistry 51:1895-910. 2012
    ..Current evidence is most consistent with a conformational adjustment of Arg183. A properly oriented Arg183 is critical for the stabilization of anions in the distal pocket and for efficient catalysis...
  49. ncbi Screening of basidiomycete fungi for the quinone-dependent sugar C-2/C-3 oxidoreductase, pyranose dehydrogenase, and properties of the enzyme from Macrolepiota rhacodes
    J Volc
    Institute of Microbiology, Academy of Sciences of the Czech Republic, Videnska 1083, 142 20 Prague 4, Czech Republic
    Arch Microbiol 176:178-86. 2001
    ..The N-terminal sequence, AVVYRHPDEL, showed significant similarity with that reported for A. bisporus...
  50. ncbi N-Acylhomoserine lactone quorum-sensing molecules are modified and degraded by Rhodococcus erythropolis W2 by both amidolytic and novel oxidoreductase activities
    Stephane Uroz
    Interactions Plantes et Micro organismes de la Rhizosphère, Institut des Sciences du Vegetal, CNRS, Batiment 23, 91198 Gif sur Yvette Cedex, France
    Microbiology 151:3313-22. 2005
    ..R. erythropolis is therefore capable of modifying and degrading AHL signal molecules through both oxidoreductase and amidolytic activities...
  51. doi Role of the WWOX gene, encompassing fragile region FRA16D, in suppression of pancreatic carcinoma cells
    Shunji Nakayama
    Division of Pathology, Department of Pathology, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    Cancer Sci 99:1370-6. 2008
    ..These findings suggest that down-modulation of Wwox expression is an early event and may be associated with the down-regulation of Smad4 protein levels during pancreatic duct carcinogenesis...
  52. doi Reconstitution of human Ero1-Lalpha/protein-disulfide isomerase oxidative folding pathway in vitro. Position-dependent differences in role between the a and a' domains of protein-disulfide isomerase
    Lei Wang
    National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
    J Biol Chem 284:199-206. 2009
    ..These data, combined with a pull-down assay and isothermal titration calorimetry measurements, enabled the minimal element for binding with Ero1-Lalpha to be mapped to the b'xa' fragment of hPDI...
  53. pmc Contribution of crenarchaeal autotrophic ammonia oxidizers to the dark primary production in Tyrrhenian deep waters (Central Mediterranean Sea)
    Michail M Yakimov
    Laboratory of Marine Molecular Microbiology, Institute for Coastal Marine Environment, CNR, Messina, Italy
    ISME J 5:945-61. 2011
    ....
  54. pmc Redox thermodynamics of high-spin and low-spin forms of chlorite dismutases with diverse subunit and oligomeric structures
    Stefan Hofbauer
    Department of Chemistry, Division of Biochemistry, VIBT Vienna Institute of BioTechnology, BOKU University of Natural Resources and Life Sciences, A 1190 Vienna, Austria
    Biochemistry 51:9501-12. 2012
    Chlorite dismutases (Clds) are heme b-containing oxidoreductases that convert chlorite to chloride and dioxygen...
  55. ncbi Methionine sulfoxide reductases in prokaryotes
    Benjamin Ezraty
    Laboratoire de Chimie Bacterienne, Institut Fédératif de Recherche Biologie Structurale et Microbiologie, Centre National de la Recherche Scientifique, 31 Chemin Joseph Aiguier, 13402 Marseille Cedex 20, France
    Biochim Biophys Acta 1703:221-9. 2005
    ....
  56. doi Nodulation of Sesbania species by Rhizobium (Agrobacterium) strain IRBG74 and other rhizobia
    Stephen P Cummings
    School of Applied Sciences, Ellison Building, University of Northumbria, Newcastle upon Tyne, UK
    Environ Microbiol 11:2510-25. 2009
    ..These data are discussed in terms of the molecular phylogeny of Sesbania and its symbionts...
  57. doi Was nitric oxide the first deep electron sink?
    Anne Lise Ducluzeau
    Laboratoire de Bioenergetique et Ingenierie des Proteines, Centre National de la Recherche Scientifique UPR9036, IFR77, Marseille Cedex 20, France
    Trends Biochem Sci 34:9-15. 2009
    ..Aerobic respiration emerged later from within this ancestral pathway via adaptation of the enzyme NO reductase to its new substrate, dioxygen...
  58. ncbi Molecular cloning and characterization of STAMP2, an androgen-regulated six transmembrane protein that is overexpressed in prostate cancer
    Ceren G Korkmaz
    Department of Molecular Biosciences, University of Oslo, Postboks 1050 Blindern, 0316 Oslo, Norway
    Oncogene 24:4934-45. 2005
    ..Taken together, these data suggest that STAMP2 may contribute to the normal biology of the prostate cell, as well as prostate cancer progression...
  59. ncbi Cytokinin oxidase regulates rice grain production
    Motoyuki Ashikari
    Bioscience and Biotechnology Center, Nagoya University, Nagoya 464 8601, Japan
    Science 309:741-5. 2005
    ..QTL pyramiding to combine loci for grain number and plant height in the same genetic background generated lines exhibiting both beneficial traits. These results provide a strategy for tailormade crop improvement...
  60. ncbi Isolation of an autotrophic ammonia-oxidizing marine archaeon
    Martin Könneke
    Department of Civil and Environmental Engineering, University of Washington, Seattle, Washington 98195, USA
    Nature 437:543-6. 2005
    ..The autotrophic metabolism of this isolate, and its close phylogenetic relationship to environmental marine crenarchaeal sequences, suggests that nitrifying marine Crenarchaeota may be important to global carbon and nitrogen cycles...
  61. pmc Unexpected diversity of chlorite dismutases: a catalytically efficient dimeric enzyme from Nitrobacter winogradskyi
    Georg Mlynek
    Department for Structural and Computational Biology, Max F Perutz Laboratories, University of Vienna, Campus Vienna Biocenter 5, A 1030 Vienna, Austria
    J Bacteriol 193:2408-17. 2011
    ..Interestingly, proteins that contain all these signatures and are phylogenetically closely related to the novel-type Cld of N. winogradskyi exist in a large number of other microbes, including other nitrite oxidizers...
  62. pmc Ce-Duox1/BLI-3 generated reactive oxygen species trigger protective SKN-1 activity via p38 MAPK signaling during infection in C. elegans
    Ransome van der Hoeven
    Department of Microbiology and Molecular Genetics, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America
    PLoS Pathog 7:e1002453. 2011
    ..Overall, a model is presented in which ROS generation by Ce-Duox1/BLI-3 activates a protective SKN-1 response via p38 MAPK signaling...
  63. ncbi Ammonia-oxidizing bacterial community composition in estuarine and oceanic environments assessed using a functional gene microarray
    Bess B Ward
    Department of Geosciences, Guyot Hall, Princeton University, Princeton, NJ, USA
    Environ Microbiol 9:2522-38. 2007
    ....
  64. ncbi Stereocomplementary bioreduction of alpha,beta-unsaturated dicarboxylic acids and dimethyl esters using enoate reductases: enzyme- and substrate-based stereocontrol
    Clemens Stueckler
    Department of Chemistry, Organic and Bioorganic Chemistry, University of Graz, Heinrichstrasse 28, 8010 Graz, Austria
    Org Lett 9:5409-11. 2007
    ..Cofactor-recycling systems (NADH/FDH/formate, NADH/GDH/glucose or NADPH/G6PDH/glucose-6-phosphate) only worked in presence of a divalent metal ion, such as Ca2+, Mg2+, or Zn2+...
  65. ncbi Ammonia oxidation and ammonia-oxidizing bacteria and archaea from estuaries with differing histories of hypoxia
    Jane M Caffrey
    Center for Environmental Diagnostics and Bioremediation, University of West Florida, Pensacola, FL, USA
    ISME J 1:660-2. 2007
    ..This suggests that AOA are significant in estuarine nitrogen cycling. Surprisingly, more of the variability in potential nitrification rates was predicted by salinity and pore water sulfide than by dissolved oxygen history...
  66. ncbi Denaturing gradient gel electrophoresis (DGGE) approaches to study the diversity of ammonia-oxidizing bacteria
    Mette Haubjerg Nicolaisen
    Department of Microbial Ecology, Institute of Biological Sciences, University of Aarhus, Ny Munkegade, Building 540, DK 8000 C, Aarhus, Denmark
    J Microbiol Methods 50:189-203. 2002
    ..The majority of retrieved sequences from all four habitats with high ammonia loads were Nitrosomonas-like and only few Nitrosospira-like sequences were detected...
  67. ncbi Shall we dance? How a multicopper oxidase chooses its electron transfer partner
    Liliana Quintanar
    Centro de Investigacion y de Estudios Avanzados, Mexico, D F, Mexico
    Acc Chem Res 40:445-52. 2007
    ....
  68. doi Shifts in the relative abundance of ammonia-oxidizing bacteria and archaea across physicochemical gradients in a subterranean estuary
    Alyson E Santoro
    Department of Civil and Environmental Engineering, Stanford University, Stanford, CA 94305, USA
    Environ Microbiol 10:1068-79. 2008
    ..These results offer new insights into the ecology of AOA and beta-AOB by elucidating conditions that may favour the numerical dominance of beta-AOB over AOA in coastal sediments...
  69. pmc Cloning the expression of a mammalian gene involved in the reduction of methionine sulfoxide residues in proteins
    J Moskovitz
    Roche Institute of Molecular Biology, Roche Research Center, Nutley, NJ 07110 1199, USA
    Proc Natl Acad Sci U S A 93:2095-9. 1996
    ..This is consistent with the observation that kidney extracts also contained the highest level of enzyme activity...
  70. ncbi Critical residues for structure and catalysis in short-chain dehydrogenases/reductases
    Charlotta Filling
    Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    J Biol Chem 277:25677-84. 2002
    ..This extends the previously recognized catalytic triad of Ser-Tyr-Lys residues to form a tetrad of Asn-Ser-Tyr-Lys in the majority of characterized short-chain dehydrogenases/reductase enzymes...
  71. ncbi Ethnic variation in tyrosinase and TYRP1 expression in photoexposed and photoprotected human skin
    Simon Alaluf
    Unilever Research, Colworth Laboratory, Sharnbrook, Bedford, UK
    Pigment Cell Res 16:35-42. 2003
    ..Moreover, the observed ethnic variation in TYRP1 protein expression suggests that TYRP1 may play a significant role in mediating ethnic differences in melanogenesis and constitutive skin pigmentation in vivo...
  72. ncbi Membrane-bound diiron carboxylate proteins
    Deborah A Berthold
    Department of Biochemistry and Biophysics, Arrhenius Laboratory for Natural Sciences, Stockholm University, Svante Arrhenius vag 12, SE 106 91 Stockholm, Sweden
    Annu Rev Plant Biol 54:497-517. 2003
    ..We discuss what is known about each enzyme as well as our expectations based on their identification as interfacially bound proteins with a diiron carboxylate active site...
  73. ncbi Methane as fuel for anaerobic microorganisms
    Rudolf K Thauer
    Max Planck Institute for Terrestrial Microbiology, Karl von Frisch Strasse, D 35043 Marburg, Germany
    Ann N Y Acad Sci 1125:158-70. 2008
    ..The first step in methane oxidation is most likely the exergonic formation of 2-methylsuccinate from fumarate and methane catalyzed by a glycine-radical enzyme...
  74. pmc Global occurrence of archaeal amoA genes in terrestrial hot springs
    Chuanlun L Zhang
    Department of Marine Sciences, University of Georgia, Athens, Georgia 30602, USA
    Appl Environ Microbiol 74:6417-26. 2008
    ..Our study demonstrates the global occurrence of putative archaeal amoA genes in a wide variety of terrestrial hot springs and suggests that geography may play an important role in selecting different assemblages of AOA...
  75. pmc Genes and enzymes involved in bacterial oxidation and reduction of inorganic arsenic
    Simon Silver
    Department of Microbiology and Immunology, MC790, University of Illinois, 835 S Wolcott Ave, Chicago, IL 60612 7344, USA
    Appl Environ Microbiol 71:599-608. 2005
  76. doi Molecular and biogeochemical evidence for ammonia oxidation by marine Crenarchaeota in the Gulf of California
    J Michael Beman
    Department of Geological and Environmental Sciences, Stanford University, Stanford, CA, USA
    ISME J 2:429-41. 2008
    ..90, P<0.001), and with 16S rRNA gene copies from marine Crenarchaeota (r2=0.85, P<0.005). These findings represent compelling evidence for an archaeal role in oceanic nitrification...
  77. pmc Archaea dominate the ammonia-oxidizing community in the rhizosphere of the freshwater macrophyte Littorella uniflora
    Martina Herrmann
    Department of Biological Sciences, Microbiology, University of Aarhus, Ny Munkegade, Building 1540, DK 8000 Aarhus C, Denmark
    Appl Environ Microbiol 74:3279-83. 2008
    ....
  78. doi Environmental genomics reveals a functional chlorite dismutase in the nitrite-oxidizing bacterium 'Candidatus Nitrospira defluvii'
    Frank Maixner
    Department für Mikrobielle Okologie, Universitat Wien, Vienna, Austria
    Environ Microbiol 10:3043-56. 2008
    ....
  79. doi Biochemistry, evolution and physiological function of the Rnf complex, a novel ion-motive electron transport complex in prokaryotes
    Eva Biegel
    Molecular Microbiology and Bioenergetics, Institute of Molecular Biosciences, Johann Wolfgang Goethe University Frankfurt Main, Frankfurt, Germany
    Cell Mol Life Sci 68:613-34. 2011
    ..The energetics of the complex and its biochemistry, as well as its evolution and cellular function in different microbes, is discussed...
  80. doi Multiple ways to make disulfides
    Neil J Bulleid
    Institute of Molecular, Cellular and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK
    Trends Biochem Sci 36:485-92. 2011
    ..Here we discuss these various pathways for disulfide formation in the mammalian ER and highlight the central role played by glutathione in regulating this process...
  81. pmc Chromate-reducing properties of soluble flavoproteins from Pseudomonas putida and Escherichia coli
    D F Ackerley
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California 94305, USA
    Appl Environ Microbiol 70:873-82. 2004
    ..The results nevertheless suggest that YieF may be an even more suitable candidate for further studies than ChrR...
  82. ncbi Genome sequence of the lignocellulose degrading fungus Phanerochaete chrysosporium strain RP78
    Diego Martinez
    US DOE Joint Genome Institute, Walnut Creek, California 94598, USA
    Nat Biotechnol 22:695-700. 2004
    ..This genome provides a high quality draft sequence of a basidiomycete, a major fungal phylum that includes important plant and animal pathogens...
  83. doi Nitrification in terrestrial hot springs of Iceland and Kamchatka
    Laila J Reigstad
    Department of Biology, Center for Geobiology, University of Bergen, Bergen, Norway
    FEMS Microbiol Ecol 64:167-74. 2008
    ..Our data provide evidence for an active role of archaea in nitrification of hot springs in a wide range of pH values and at a high temperature...
  84. doi Spatial distribution of Bacteria and Archaea and amoA gene copy numbers throughout the water column of the Eastern Mediterranean Sea
    Daniele De Corte
    Department of Biological Oceanography, Royal Netherlands Institute for Sea Research NIOZ, Den Burg, The Netherlands
    ISME J 3:147-58. 2009
    ..Hence, the archaeal community in the Eastern Mediterranean Sea appears to be highly stratified despite the absence of major temperature and density gradients between the meso- and bathypelagic waters of the Mediterranean Sea...
  85. doi Population ecology of nitrifying archaea and bacteria in the Southern California Bight
    J Michael Beman
    Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA
    Environ Microbiol 12:1282-92. 2010
    ..These data capture a dynamic nitrogen cycle in which multiple microbial groups appear to be active participants...
  86. ncbi Defective antigen processing in GILT-free mice
    M Maric
    Section of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520, USA
    Science 294:1361-5. 2001
    ..The response to hen egg lysozyme, a model antigen with a compact structure containing four disulfide bonds, was examined in detail...
  87. ncbi Peptide methionine sulfoxide reductase: structure, mechanism of action, and biological function
    Herbert Weissbach
    Center for Molecular Biology and Biotechnology, Florida Atlantic University, Boca Raton, Florida 33431, USA
    Arch Biochem Biophys 397:172-8. 2002
    ..There is growing evidence that MsrA plays an important role in protecting cells against oxidative damage. This paper reviews the biochemical properties and biological role of MsrA...
  88. pmc Mutations in the 3beta-hydroxysterol Delta24-reductase gene cause desmosterolosis, an autosomal recessive disorder of cholesterol biosynthesis
    H R Waterham
    Department of Pediatrics, Emma Children s Hospital, Academic Medical Center, University of Amsterdam, 1100 DE Amsterdam, The Netherlands
    Am J Hum Genet 69:685-94. 2001
    ..helix, and is a member of a recently defined family of flavin adenine dinucleotide (FAD)-dependent oxidoreductases. Conversion of desmosterol to cholesterol by DHCR24 in vitro is strictly dependent on reduced nicotinamide ..
  89. ncbi Crystal structure of a laccase from the fungus Trametes versicolor at 1.90-A resolution containing a full complement of coppers
    Klaus Piontek
    Institute of Biochemistry, Swiss Federal Institute of Technology ETH, ETH Honggerberg, Building HPM, Room D 8 1 2, CH 8093 Zurich, Switzerland
    J Biol Chem 277:37663-9. 2002
    ..Based on the present structural data and sequence comparisons, a mechanism is presented to explain how laccases could tune their redox potential by as much as 200 mV...
  90. pmc The Steap proteins are metalloreductases
    Robert S Ohgami
    Department of Pathology, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Blood 108:1388-94. 2006
    ..Finally, the pattern of tissue expression and subcellular localization of these proteins suggest they are physiologically relevant cupric reductases and ferrireductases in vivo...
  91. doi Nuclear localization of active HGF receptor Met in aggressive MDA-MB231 breast carcinoma cells
    Emanuela Matteucci
    Dipartimento di Morfologia Umana e Scienze Biomediche Città Studi, University of Milan, Italy
    Carcinogenesis 30:937-45. 2009
    ..Wwox/Met system can be suggested as a potential target to impair breast carcinoma progression...
  92. pmc Involvement of an alternative oxidase in oxidative stress and mycelium-to-yeast differentiation in Paracoccidioides brasiliensis
    Vicente P Martins
    Departamento de Analises Clinicas, Toxicologicas e Bromatologicas, Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Av Café, S N, 14040 903 Ribeirao Preto, Sao Paulo, Brazil
    Eukaryot Cell 10:237-48. 2011
    ..brasiliensis...
  93. doi Oxygen activation in flavoprotein oxidases: the importance of being positive
    Giovanni Gadda
    Department of Chemistry, Georgia State University, Atlanta, Georgia 30302 4098, United States
    Biochemistry 51:2662-9. 2012
    ..Mutagenesis has disclosed nonpolar sites in O(2)-reducing enzymes that utilize copper/TPQ or iron. It is predicted that classes of O(2)-reducing enzymes utilizing other cofactors also contain a similar catalytic motif...
  94. doi TaCKX6-D1, the ortholog of rice OsCKX2, is associated with grain weight in hexaploid wheat
    Lei Zhang
    College of Agronomy, Shenyang Agricultural University, Shenyang, 110866, China
    New Phytol 195:574-84. 2012
    ..Our study also sheds light on the mechanisms of grain development and domestication of wheat, as well as the functional divergence of orthologs in comparative genomics...
  95. pmc Impact of subunit and oligomeric structure on the thermal and conformational stability of chlorite dismutases
    Stefan Hofbauer
    University of Natural Resources and Life Sciences, Vienna, Austria
    Biochim Biophys Acta 1824:1031-8. 2012
    Chlorite dismutases (Cld) are unique heme b containing oxidoreductases that convert chlorite to chloride and dioxygen...
  96. pmc Understanding the roles of strictly conserved tryptophan residues in O2 producing chlorite dismutases
    Béatrice Blanc
    Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46656, USA
    Dalton Trans 42:3156-69. 2013
    ..These observations and the lack of redox protection for the heme in any of the Trp mutants suggests a tendency for protein radical formation in DaCld that is independent of any of these conserved active site residues...
  97. pmc A pH-regulated quality control cycle for surveillance of secretory protein assembly
    Stefano Vavassori
    Division of Genetics, San Raffaele Scientific Institute, 20132 Milan, Italy
    Mol Cell 50:783-92. 2013
    ..The ERp44 assembly control cycle couples secretion fidelity and efficiency downstream of the calnexin/calreticulin and BiP-dependent quality control cycles. ..
  98. pmc Ero1-α and PDIs constitute a hierarchical electron transfer network of endoplasmic reticulum oxidoreductases
    Kazutaka Araki
    Molecular Profiling Research Center for Drug Discovery, National Institute of Advanced Industrial Science and Technology, Koto ku, Tokyo 135 0064, Japan
    J Cell Biol 202:861-74. 2013
    Ero1-α and endoplasmic reticulum (ER) oxidoreductases of the protein disulfide isomerase (PDI) family promote the efficient introduction of disulfide bonds into nascent polypeptides in the ER...
  99. pmc Selective knockdown of ceramide synthases reveals complex interregulation of sphingolipid metabolism
    Thomas D Mullen
    Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA
    J Lipid Res 52:68-77. 2011
    ..These data suggest that sphingolipid metabolism is robustly regulated by both redundancy in CerS-mediated Cer synthesis and counter-regulation of CerS expression...
  100. pmc Nitric oxide-mediated maintenance of redox homeostasis contributes to NPR1-dependent plant innate immunity triggered by lipopolysaccharides
    Aizhen Sun
    Ministry of Education Key Laboratory of Laser Life Science and Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, China
    Plant Physiol 160:1081-96. 2012
    ..Moreover, NPR1 plays an important role in LPS-triggered plant innate immunity...
  101. ncbi Stress-induced co-expression of alternative respiratory chain components in Arabidopsis thaliana
    Rachel Clifton
    Plant Molecular Biology Group, School of Biomedical and Chemical Sciences, The University of Western Australia, Crawley, Western Australia, Australia
    Plant Mol Biol 58:193-212. 2005
    ..These treatment sets emphasise the multiplicity of pathways affecting alternative electron transport components in plants...

Research Grants119 found, 100 shown here

  1. Pyruvate Dehydrogenase kinase as Therapeutic Target for Hepatic Steatosis, Obesit
    Robert A Harris; Fiscal Year: 2012
    ..We therefore believe the proposed work has the potential to have a significant impact on the health care of Veterans. ..
  2. Anti-tumor properties of curcumin in oral cancers: role of thioredoxin reductase
    STEPHEN WILLIAM TUTTLE; Fiscal Year: 2010
    ..However, curcumin has been effective in tumors, such as colon and HNC, where direct access to the drug is possible. The primary aim of this study is to develop curcumin as a chemotherapeutic and radiation sensitizer for treating HNC.. ..
  3. Paolo Fanti; Fiscal Year: 2014
    ....
  4. Iron-mediated vascular disease in sickle cell disease.
    John C Wood; Fiscal Year: 2010
    ..This proposal represents an essential first step in the design of a subsequent clinical trial to improve vascular function in SCD patients. ..
  5. Angiotensin Adrenergic Interactions in the Kidney
    Roland C Blantz; Fiscal Year: 2013
    ....
  6. Qinghua Sun; Fiscal Year: 2015
    ....
  7. ANTHONY JOHN KANAI; Fiscal Year: 2016
    ..Hypothesis: FA-NO2 are radioprotective by desensitizing TRPA1 and TRPV1 channels and BDNF-AB and NGF-AB are therapeutic by inhibiting nerve growth and sensitization in bladder and spinal cord. ..
  8. Pathogenesis and Treatment of Liver Disease in Transaldolase Deficiency
    Andras Perl; Fiscal Year: 2013
    ..These studies should generate fundamental new information on the cause and treatment of potentially fatal diseases of the liver. ..
  9. ENEIQUE A MESRI; Fiscal Year: 2016
    ..So our work will allow us to not only to identify mechanisms of KS carcinogenesis but also will help to identify potential new target and new drugs for anti-KS therapy. ..
  10. Inhibition of human neutrophil function by Francisella tularensis
    Lee Ann H Allen; Fiscal Year: 2012
    ..The results of this study may lead to new treatments to combat this severe and often fatal lung infection. ..
  11. Lung Lysyl Oxidase Regulation by Metal Ion Homeostasis
    Wande Li; Fiscal Year: 2013
    ..The outcomes of the proposed research are expected to enhance our understanding of mechanisms of LO gene silence by Cd providing the basis for developing prophylaxis and treatment strategies for Cd-related lung diseases. ..
  12. Gary Cecchini; Fiscal Year: 2014
    ..Using the SIRT3 KO mouse model, it will be determined if the properties of cardiac tissue such as pre- and post-conditioning are altered by acetylation/deacetylation of proteins. ..
  13. Samantha M Yeligar; Fiscal Year: 2014
    ..Thus, this K99/R00 application provides an excellent opportunity to advance the career of a talented and promising investigator. ..
  14. Functional Genomics of the Mitochondrial Proteome
    Dennis R Winge; Fiscal Year: 2011
    ..The function of up to 30% of the mitochondrial proteome is unknown. This proposal will elucidate the function of these un-annotated mitochondrial proteins, providing new insights into the role of mitochondria in human disease. ..
  15. A Soft Topical Antiandrogenic Drug
    Wei Chu Xu; Fiscal Year: 2013
    ..The synthesis and discovery of an optimal locally active androgen antagonist to be applied to the skin to treat acne, alopecia, seborrhea (and hirsutism in women) are the subjects of this application. ..
  16. Targeting Inflammation for the Amelioration of Cisplatin-Hearing Loss
    Vickram Ramkumar; Fiscal Year: 2011
    ..We believe the information gained from this study will lead to potentially new treatments for treating hearing loss. ..
  17. Mark W Chapleau; Fiscal Year: 2015
    ..Inhibition of Ang II-mediated effects by activation of CGRP/RAMP1 receptors has widespread implications in hypertension and heart failure. ..
  18. Group A Streptococcus responses to oxidative stress
    Ioannis Gryllos; Fiscal Year: 2010
    ....
  19. REGULATION OF GENE EXPRESSION BY DIETARY FAT
    Lisa M Salati; Fiscal Year: 2012
    ..This project will provide important new data on the ways in which dietary fat can regulate intracellular metabolism. ..
  20. Xianglin Shi; Fiscal Year: 2015
    ..Present study attempts to identify cyanidin-3-glucoside, a plant-derived compound, as a mechanism-based preventive agent against UV-induced skin cancers. ..
  21. Laura L Dugan; Fiscal Year: 2014
    ..abstract_text> ..
  22. ICSBP Function During Myeloid Differentiation
    ELIZABETH ANN EKLUND; Fiscal Year: 2011
    ..Functional characterization of such a pathway has implications for identifying early markers of disease progression in human myeloid malignancy and rational targets for molecular therapeutic approaches to diseases such as CML and MDS. ..
  23. Protein Nitration in the Placenta
    Leslie Myatt; Fiscal Year: 2012
    ....
  24. A novel peroxidase in vascular endothelium and the development of atherosclerosis
    Guangjie Cheng; Fiscal Year: 2012
    ..Furthermore, we anticipate this research will lead to the development of a new drug that inhibits the enzyme's activity and blocks the change of LDL. ..
  25. Mahin D Maines; Fiscal Year: 2015
    ..In addition, the enzyme activity is necessary for protection against the fatal "green jaundice". Our work has revealed a novel approach for development of therapeutic interventions in a range of human diseases. ..
  26. William M Nauseef; Fiscal Year: 2016
    ..abstract_text> ..
  27. REGULATION OF PULMONARY CIRCULATION IN FETUS AND NEWBORN
    Girija G Konduri; Fiscal Year: 2013
    ..These studies will identify an important new source of oxidative stress in PPHN. These observation may lead to new targeted therapies to improve vasodilation and oxygenation in PPHN. ..
  28. James B Martins; Fiscal Year: 2014
    ..Similarly such drugs may be combined with other antioxidants to prevent dangerous heart rhythms. ..
  29. Small Molecule targeting of NADPH oxidase in neutrophils
    Marie Dominique Filippi; Fiscal Year: 2010
    ..Therefore, our study will help delivering a novel pharmaceutical target, and suitable lead compounds for the treatment of lung inflammation, such as ALI and ARDS. ..
  30. Arsenic Trioxide and Acute Myeloid Leukemia
    Yongkui Jing; Fiscal Year: 2012
    ..Our goal will be to utilize As2O3 in combination with 4 HPR or EA analogs in clinical trials in patients with refractory, secondary or in elderly patients with acute myelogenous leukemia. ..
  31. Nitric Oxide in Hemodialysis AV Fistula Maturation
    Richard A Cohen; Fiscal Year: 2010
    ....
  32. Role of Mitochondria in the Regulation of Iron metabolism by Alcohol
    DUYGU DEE DEE HARRISON-FINDIK; Fiscal Year: 2012
    ..The knowledge obtained from these studies, characterizing the pivotal role of mitochondria, will enable us to determine the mechanisms of liver injury caused by iron and alcohol in patients with ALD. ..
  33. Air Pollution on Adiposity and Vascular Dysfunction: White or Brown Matters?
    Qinghua Sun; Fiscal Year: 2010
    ..abstract_text> ..
  34. X chromosome, injury and infection
    Zoltan Spolarics; Fiscal Year: 2012
    ..Better understanding of the protecting cellular mechanisms that are in effect during septic conditions could lead to advanced protocols in treating the critically ill. ..
  35. Lucy A Waskell; Fiscal Year: 2014
    ....
  36. Margot S Damaser; Fiscal Year: 2014
    ..We will explore the possibility of making this therapy noncellular to avoid complications of cell therapy. This research is of high significance for development of improved therapies for female pelvic floor disorders. ..
  37. Protection of Brain Injury from Cyanide Poisoning by Carnosic Acid
    Stuart A Lipton; Fiscal Year: 2013
    ..To investigate neuroprotective effects of CA in an in vitro model of cyanide poisoning. Specific Aim 2. To examine neuroprotective effects of CA in an in vivo mouse model mimicking the effects of cyanide ingestion. ..
  38. Vickram Ramkumar; Fiscal Year: 2016
    ..Overall, we believe that this study will provide the basis for the use of transplatin to alleviate cisplatin toxicities in cancer patients. ..
  39. C Michael Hart; Fiscal Year: 2016
    ..The results of this proposal can thereby define novel and effective therapeutic strategies to regulate programs of gene expression involved in PH pathogenesis. ..
  40. N-Acetylcysteine and Milk Thistle for Treatment of Diabetic Nephropathy
    Paolo Fanti; Fiscal Year: 2011
    ..Throughout the trial, we will monitor the safety and tolerability of this combination treatment. ..
  41. Mechanism(s) of Alcoholic Pancreatitis
    Bhupendra S Kaphalia; Fiscal Year: 2011
    ....
  42. Ischemia/Reperfusion Injury of Human Endothelium: Role of Glucose and Statins
    THOMAS JAY EBERT; Fiscal Year: 2013
    ..These studies will carefully describe the effects of glucose and statins on the function of the lining of blood vessels in humans. This new knowledge might lessen unwanted side effects related to diabetes. ..
  43. Biochemical Characterization of Cytochrome b5 Reductase in Candida albicans
    MARY JOLENE PATRICIA HOLLOWAY; Fiscal Year: 2010
    ..I will also learn new techniques used in biochemistry and proteomics, such as mass spectrometry, protein pull-down assays, and other methods involved in the characterization of proteins. ..
  44. New therapeutics for the treatment of Acinetobactor baumannii infections.
    ALLEN BERNARD REITZ; Fiscal Year: 2013
    ....
  45. Mechanisms of Angiogenesis in Retinopathy of Prematurity
    Mary Elizabeth Hartnett; Fiscal Year: 2009
    ..g., dihydroethidium);and NADPH oxidase activation. ..
  46. Alcohol-Induced Bone Resorption: The Role of Oxidative Stress
    Martin J J Ronis; Fiscal Year: 2013
    ..In addition, in vivo studies will be conducted to examine the ability of antioxidants to block EtOH-induced bone resorption. ..
  47. Karen Block; Fiscal Year: 2015
    ..This work may have major therapeutic implications. ..
  48. Roles of oxidation and inflammation in aortic stiffening
    David G Harrison; Fiscal Year: 2013
    ..Our combined expertise in the physiology of hypertension, connective tissue biochemistry and cardiovascular histomorphology place us in a unique position to pursue these directions of research. ..
  49. Pharmacologic Interventions for Cardiovascular Disease in Obstructive Sleep Apnea
    Barbara J Morgan; Fiscal Year: 2013
    ..These interventions are novel, relevant, unobtrusive, relatively inexpensive, and could drasticallv change the treatment and possible prevention of cardiovascular disease in OSA. ..
  50. MARY ELIZABETH RUTH HARTNETT; Fiscal Year: 2016
    ..g., dihydroethidium);and NADPH oxidase activation. ..
  51. Needle-Implantable, Wireless Multi-Sensor for Continuous Glucose Monitoring
    Santhisagar Vaddiraju; Fiscal Year: 2010
    ..e. mice, rats) will provide an invaluable tool in diabetes drug development. ..
  52. Role of ALDH7A1 in Ethanol-Induced Oxidative Damage
    CHAD NICHOLAS BROCKER; Fiscal Year: 2011
    ..This long term goal of this project is to elucidate the protective functions of ALDH7A1 during excessive alcohol consumption. ..
  53. Dependency of O-3 Induced Lung Mucus Hypersecretion on NQ01
    W Michael Foster; Fiscal Year: 2010
    ....
  54. Tsung Ung W Woo; Fiscal Year: 2014
    ..Findings of the proposed studies are expected to shed light on the conceptualization of treatment and prevention strategies that aim at fundamentally correcting the underlying neural circuit deficits. ..
  55. Na+/H+-exchanger-1 and Diabetic Neuropathy
    MARK ANTHONY YOREK; Fiscal Year: 2012
    ....
  56. A Clinical Trial of Aspirin and Simvastatin in Pulmonary Arterial Hypertension
    Steven Kawut; Fiscal Year: 2009
    ..We aim to investigate safe but innovative therapies which could remodel the pulmonary vasculature and improve outcomes in this currently incurable disease. ..
  57. Redox regulation of phagocyte NOX2 in inflammation and aging
    Robert A Clark; Fiscal Year: 2013
    ....
  58. ANN NARDULLI; Fiscal Year: 2014
    ..Our studies will provide critical new information about the role of a variety of estrogens and progestins in the brain and aid in the design of more effective hormonal treatments for women of all ages. ..
  59. Amelioration of cisplatin ototoxicity by transplatin
    Debashree Mukherjea; Fiscal Year: 2010
    ..Such a treatment could improve the quality of life of cancer patients who would otherwise face many years of poor communication because of hearing loss caused by cisplatin treatment. ..
  60. William M Pandak; Fiscal Year: 2016
    ..A better understanding of cell cholesterol, fatty acid, and bile acid metabolism is crucial in order to develop more effective therapies for lipid related disorders. ..
  61. DlaT as a transcriptional regulator in non-replicating Mycobacterium tuberculosis
    Ruslana Bryk; Fiscal Year: 2012
    ....
  62. Asthma Increases Vaso-occlusion in Sickle Cell Disease
    Kirkwood A Pritchard; Fiscal Year: 2013
    ..If we are correct, then our drug therapies should improve blood vessel function and decrease airway resistance in SCD mice with experimental asthma. ..
  63. HUA LINDA CAI; Fiscal Year: 2016
    ..Characterization of the CMEC-cardiomyocyte signaling axis may additionally provide novel insights into potential cell-based therapies. ..
  64. Ke Jian Liu; Fiscal Year: 2016
    ..Additionally, these studies may lead to testable hypotheses regarding potential arsenic targets in cancer and other arsenic-associated diseases. ..
  65. Yi Lu; Fiscal Year: 2016
    ..Therefore the work will make important contributions to healthcare, as it will provide a molecular basis for understanding two enzymes important to human health. ..
  66. John R Hoidal; Fiscal Year: 2016
    ..It will impact our ability to prevent or reduce the enormous medical burden caused by cigarette smoking. Nowhere is the need for new approaches with clinical application more important in pulmonary diseases than in COPD. ..
  67. Characterization of the thioredoxins system in the diabetic retina
    Folami Lamoke; Fiscal Year: 2013
    ..Aim 2)) Test the hypothesis that HG/diabetes induces TrxR1 protein nitration and this effect contributes to oxidative retinal endothelial cell injury. ..
  68. JOHN BRANNON GARY; Fiscal Year: 2014
    ..Such findings of the biological relevance of Cu(III) would provide a complete paradigm shift in copper biochemistry (e.g. Fe(IV)-oxo intermediates for non-heme iron sites). ..
  69. Robert Harris; Fiscal Year: 2015
    ..Therefore, this grant proposal is highly relevant to Veterans Health Care since colorectal cancer is estimated to claim 50,000 Veteran lives in 2010. ..
  70. Lee Ann H Allen; Fiscal Year: 2016
    ....
  71. Statins for Pulmonary and Cardiac Complications of Chronic HIV (The SPARC Trial)
    Stephen R Wisniewski; Fiscal Year: 2013
    ....
  72. JUNG JA P KIM; Fiscal Year: 2015
    ....
  73. Michael Regnier; Fiscal Year: 2015
    ..Results from these studies will provide valuable insight on whether sustained enhancement of myofilament contractility (with dATP) has potential for treatment of heart failure in animal models and humans. ..
  74. Xiang Fang; Fiscal Year: 2015
    ..The proposed study will provide insight into the mechanism by which mutant CUG RNA disrupts PGC-1 activity and impair Mt function, and might lead to the development of intervention through modulating PGC-1 signaling in DM1. ..
  75. Saurabh Chatterjee; Fiscal Year: 2014
    ..abstract_text> ..
  76. Robert J Turesky; Fiscal Year: 2014
    ..abstract_text> ..
  77. Ann Richmond; Fiscal Year: 2016
    ....
  78. Molecular Pathogenesis of Coenzyme Q10 Deficiency
    Michio Hirano; Fiscal Year: 2012
    ..Aim 4: In collaboration with Professor Pl[unreadable]cido Navas, University of Sevilla, Spain, we will characterize CoQ10 biosynthetic genes and mutations in yeast. ..
  79. KAREN TARASZKA HASTINGS; Fiscal Year: 2015
    ..Since the effect of GILT is not limited to the presentation of TRP1 or cutaneous autoantigens, modulation of GILT expression or activity may be a broadly applied therapeutic approach for autoimmune disease. ..
  80. NADPH OXIDASE REGULATION OF THE MACROPHAGE INFLAMMATORY PHENOTYPE IN SEPSIS
    John W Christman; Fiscal Year: 2013
    ..abstract_text> ..
  81. Cell Models for Alzheimer's disease (AD): Lipids and Related Signaling Pathways
    Grace Y Sun; Fiscal Year: 2012
    ..These collaborative studies should identify novel strategies to control chronic inflammation and neurodegeneration in AD. ..
  82. Redox Triggering of Glomerular NALP3 Inflammasomes in Hyperhomocysteinemia
    Justine M Abais; Fiscal Year: 2013
    ....
  83. Jeffrey C Rathmell; Fiscal Year: 2014
    ....
  84. Targeted Degradation of DNA Damage Response Proteins by Autophagy
    Thomas J Begley; Fiscal Year: 2013
    ..We will perform genetic, biochemical and proteomic based experiments in S. cerevisiae to test our hypothesis and to define the molecular signals that allow autophagy to target specific proteins for degradation. ..
  85. Elevated Zinc in Ischemia and reperfusion
    Yang V Li; Fiscal Year: 2013
    ....
  86. Mechanisms of Early Life Stress-Induced Endothelial Dysfunction
    Dao Ho; Fiscal Year: 2013
    ..New investigations into how epigenetic mechanisms, especially HDACs, regulate vascular function offer an innovative direction for therapies. ..
  87. Shinichi Someya; Fiscal Year: 2016
    ..Currently there is no treatment for AHL. The results of our proposal will provide the opportunity to identify interventions that will delay presbycusis in humans. ..
  88. SHERRY L ABBOUD-WERNER; Fiscal Year: 2016
    ..abstract_text> ..
  89. Gino A Cortopassi; Fiscal Year: 2015
    ..abstract_text> ..
  90. The Biological and Chemical Function of Selenium in Enzymes
    Robert J Hondal; Fiscal Year: 2013
    ..Cancer cells must divide rapidly to cause pathogenesis and require increased expression of thioredoxin reductase to survive. ..
  91. JEFFREY BENTON HODGIN; Fiscal Year: 2014
    ....
  92. Michelle R Arkin; Fiscal Year: 2014
    ..The proposed research activity is in advance of a collaborative and longer-term lead optimization program that will continue to utilize the tools employed or developed herein. ..
  93. PETER WALLACE STACPOOLE; Fiscal Year: 2016
    ....
  94. ADAM CARL STRAUB; Fiscal Year: 2015
    ..abstract_text> ..
  95. Arjang Djamali; Fiscal Year: 2015
    ....
  96. Ingo K Mellinghoff; Fiscal Year: 2016
    ..Results of our studies will shed light on mechanisms through which an "oncometabolite" can regulate the molecular pathogenesis of cancer and refine our view of mutant IDH1 as a potential therapeutic target in human glioma. ..
  97. Victor J Thannickal; Fiscal Year: 2016
    ....