phosphopyruvate hydratase

Summary

Summary: An enzyme of the lyase class that catalyzes the dehydration of 2-phosphoglycerate to form phosphoenolpyruvate. (Dorland, 28th ed) EC 4.2.1.11.

Top Publications

  1. ncbi Genes of glycolysis are ubiquitously overexpressed in 24 cancer classes
    B Altenberg
    Bioinformatics Group, European Molecular Biology Laboratory, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    Genomics 84:1014-20. 2004
  2. ncbi Autoimmunity to specific citrullinated proteins gives the first clues to the etiology of rheumatoid arthritis
    Natalia Wegner
    The Kennedy Institute of Rheumatology, Imperial College London, London, UK
    Immunol Rev 233:34-54. 2010
  3. ncbi Adult rat and human bone marrow stromal cells differentiate into neurons
    D Woodbury
    Department of Neuroscience and Cell Biology, UMDNJ Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    J Neurosci Res 61:364-70. 2000
  4. ncbi Enolase-1 promotes plasminogen-mediated recruitment of monocytes to the acutely inflamed lung
    Malgorzata Wygrecka
    Department of Biochemistry, Faculty of Medicine, University of Giessen Lung Center, Giessen, Germany
    Blood 113:5588-98. 2009
  5. ncbi Enolase in the RNA degradosome plays a crucial role in the rapid decay of glucose transporter mRNA in the response to phosphosugar stress in Escherichia coli
    Teppei Morita
    Division of Biological Science, Graduate School of Science, Nagoya University, Chikusa, Nagoya 464 8602, Japan
    Mol Microbiol 54:1063-75. 2004
  6. pmc LOS2, a genetic locus required for cold-responsive gene transcription encodes a bi-functional enolase
    Hojoung Lee
    Department of Plant Sciences, University of Arizona, Tucson, AZ 85721, USA
    EMBO J 21:2692-702. 2002
  7. ncbi α-Enolase: a promising therapeutic and diagnostic tumor target
    Michela Capello
    Department of Medicine and Experimental Oncology, Center for Experimental Research and Medical Studies CERMS, San Giovanni Battista Hospital, University of Turin, Turin, Italy
    FEBS J 278:1064-74. 2011
  8. ncbi Antibodies to citrullinated alpha-enolase peptide 1 are specific for rheumatoid arthritis and cross-react with bacterial enolase
    Karin Lundberg
    Kennedy Institute of Rheumatology, Imperial College London, London, UK
    Arthritis Rheum 58:3009-19. 2008
  9. ncbi Mass spectrometry analysis of the post-translational modifications of alpha-enolase from pancreatic ductal adenocarcinoma cells
    Weidong Zhou
    Center for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, Virginia 20110, USA
    J Proteome Res 9:2929-36. 2010
  10. ncbi Interactions of enolase isoforms with tubulin and microtubules during myogenesis
    A Keller
    Laboratoire CRRET, CNRS UMR 7149, Universite Paris 12, 94010 Creteil, France
    Biochim Biophys Acta 1770:919-26. 2007

Research Grants

  1. GENOMIC ENZYMOLOGY: THE CROTONASE SUPERFAMILY
    JOHN GERLT; Fiscal Year: 2003
  2. GENOMIC ENZYMOLOGY: THE ENOLASE SUPERFAMILY
    JOHN GERLT; Fiscal Year: 2006
  3. Aging as a risk factor for seizure-induced cell death
    PAULA SCHAUWECKER; Fiscal Year: 2007
  4. Genetic Regulation of Seizure-Induced Neurogenesis
    PAULA SCHAUWECKER; Fiscal Year: 2004
  5. Signal Transduction Mechanisms in Suicide Brain
    Yogesh Dwivedi; Fiscal Year: 2008
  6. POSTRECEPTOR DYSREGULATION IN DEPRESSION
    Yogesh Dwivedi; Fiscal Year: 2004
  7. Validating microRNA Analysis in Human Postmortem Brain
    Yogesh Dwivedi; Fiscal Year: 2008
  8. Epileptogenicity in the Developing Brain
    Raman Sankar; Fiscal Year: 2007
  9. Synaptosomal Protein Changes After EtOH Self-Administration
    Frank Witzmann; Fiscal Year: 2006
  10. Novel Immunological Modifer as a Tissue Protector
    MICHAEL VITEK; Fiscal Year: 2006

Detail Information

Publications265 found, 100 shown here

  1. ncbi Genes of glycolysis are ubiquitously overexpressed in 24 cancer classes
    B Altenberg
    Bioinformatics Group, European Molecular Biology Laboratory, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    Genomics 84:1014-20. 2004
    ..This classification may be useful when cancer therapies aimed at the Warburg effect are designed...
  2. ncbi Autoimmunity to specific citrullinated proteins gives the first clues to the etiology of rheumatoid arthritis
    Natalia Wegner
    The Kennedy Institute of Rheumatology, Imperial College London, London, UK
    Immunol Rev 233:34-54. 2010
    ..Thus, both smoking and Porphyromonas gingivalis are attractive etiological agents for further investigation into the gene/environment/autoimmunity triad of RA...
  3. ncbi Adult rat and human bone marrow stromal cells differentiate into neurons
    D Woodbury
    Department of Neuroscience and Cell Biology, UMDNJ Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    J Neurosci Res 61:364-70. 2000
    ..Consequently, adult marrow stromal cells can be induced to overcome their mesenchymal commitment and may constitute an abundant and accessible cellular reservoir for the treatment of a variety of neurologic diseases...
  4. ncbi Enolase-1 promotes plasminogen-mediated recruitment of monocytes to the acutely inflamed lung
    Malgorzata Wygrecka
    Department of Biochemistry, Faculty of Medicine, University of Giessen Lung Center, Giessen, Germany
    Blood 113:5588-98. 2009
    ..These data suggest an important mechanism of inflammatory cell invasion mediated by increased cell-surface expression of ENO-1...
  5. ncbi Enolase in the RNA degradosome plays a crucial role in the rapid decay of glucose transporter mRNA in the response to phosphosugar stress in Escherichia coli
    Teppei Morita
    Division of Biological Science, Graduate School of Science, Nagoya University, Chikusa, Nagoya 464 8602, Japan
    Mol Microbiol 54:1063-75. 2004
    ..In addition, we show that PNPase and RhlB within the degradosome cooperate to eliminate short degradation intermediates of ptsG mRNA...
  6. pmc LOS2, a genetic locus required for cold-responsive gene transcription encodes a bi-functional enolase
    Hojoung Lee
    Department of Plant Sciences, University of Arizona, Tucson, AZ 85721, USA
    EMBO J 21:2692-702. 2002
    ..Our results demonstrate that cold-responsive gene transcription in plants is controlled by a bi-functional enolase...
  7. ncbi α-Enolase: a promising therapeutic and diagnostic tumor target
    Michela Capello
    Department of Medicine and Experimental Oncology, Center for Experimental Research and Medical Studies CERMS, San Giovanni Battista Hospital, University of Turin, Turin, Italy
    FEBS J 278:1064-74. 2011
    ..In our opinion, this information can pave the way for effective new therapeutic and diagnostic strategies to counteract the growth of the most aggressive human disease...
  8. ncbi Antibodies to citrullinated alpha-enolase peptide 1 are specific for rheumatoid arthritis and cross-react with bacterial enolase
    Karin Lundberg
    Kennedy Institute of Rheumatology, Imperial College London, London, UK
    Arthritis Rheum 58:3009-19. 2008
    ..To map the antibody response to human citrullinated alpha-enolase, a candidate autoantigen in rheumatoid arthritis (RA), and to examine cross-reactivity with bacterial enolase...
  9. ncbi Mass spectrometry analysis of the post-translational modifications of alpha-enolase from pancreatic ductal adenocarcinoma cells
    Weidong Zhou
    Center for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, Virginia 20110, USA
    J Proteome Res 9:2929-36. 2010
    ..The result showed that more acetylated lysines, methylated aspartic acids, and glutamic acids were found in PDAC cells than that of normal pancreatic duct cells...
  10. ncbi Interactions of enolase isoforms with tubulin and microtubules during myogenesis
    A Keller
    Laboratoire CRRET, CNRS UMR 7149, Universite Paris 12, 94010 Creteil, France
    Biochim Biophys Acta 1770:919-26. 2007
    ..We suggest that the binding of enolase to microtubules could contribute to the regulation of the dynamism of the cytoskeletal filaments known to occur during the transition from myoblast to myotubes...
  11. ncbi Isolation and characterization of alpha-enolase, a novel fibronectin-binding protein from Streptococcus suis
    Miriam Esgleas
    Groupe de Recherche sur les Maladies Infectieuses du Porc GREMIP and Centre de Recherche en Infectiologie Porcine CRIP, Faculte de Medecine Veterinaire, Universite de Montreal, Quebec, Canada
    Microbiology 154:2668-79. 2008
    ..suis...
  12. ncbi ENO1, a potential prognostic head and neck cancer marker, promotes transformation partly via chemokine CCL20 induction
    Sen Tien Tsai
    Department of Otolaryngology, National Cheng Kung University Hospital, Tainan 70428, Taiwan, ROC
    Eur J Cancer 46:1712-23. 2010
    ..Together, we demonstrate a prognostic role of ENO1 overexpression in head and neck cancer and ENO1-mediated promotion of cell transformation and invasion partly via induced CCL20 expression...
  13. ncbi An integrated humoral and cellular response is elicited in pancreatic cancer by alpha-enolase, a novel pancreatic ductal adenocarcinoma-associated antigen
    Paola Cappello
    Center for Experimental Research and Medical Studies, San Giovanni Battista Hospital, Torino, Italy
    Int J Cancer 125:639-48. 2009
    ..It is thus a promising and clinically relevant molecular target candidate for immunotherapeutic approaches as new adjuvants to conventional treatments in pancreatic cancer...
  14. ncbi Glial and neuronal proteins in serum predict outcome after severe traumatic brain injury
    P E Vos
    Department of Neurology, University Medical Centre Nijmegen, The Netherlands
    Neurology 62:1303-10. 2004
    ..To study the ability of glial (glial fibrillary acidic protein [GFAP] and S100b) and neuronal (neuron specific enolase [NSE]) protein levels in peripheral blood to predict outcome after severe traumatic brain injury...
  15. ncbi Proteomics-based identification of alpha-enolase as a tumor antigen in non-small lung cancer
    Ping He
    Department of Molecular Medicine, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Cancer Sci 98:1234-40. 2007
    ..Therefore, autoantibodies against alpha-enolase may constitute a promising biomarker for NSCLC...
  16. pmc Quantitative proteomics of the tonoplast reveals a role for glycolytic enzymes in salt tolerance
    Bronwyn J Barkla
    Instituto de Biotecnologia, Universidad Nacional Autonoma de Mexico, Colonia Miraval, Cuernavaca, Morelos, Mexico
    Plant Cell 21:4044-58. 2009
    ..The association of glycolytic proteins with the tonoplast may not only channel ATP to the V-ATPase, but also directly upregulate H(+)-pump activity...
  17. ncbi Identification of alpha-enolase as an autoantigen in lung cancer: its overexpression is associated with clinical outcomes
    Gee Chen Chang
    Division of Chest Medicine, Department of Internal Medicine, Taichung Veterans General Hospital, Taipei, Taiwan, Republic of China
    Clin Cancer Res 12:5746-54. 2006
    ..In this study, we intended to identify more TAAs in pleural effusion-derived tumor cells...
  18. ncbi Inhibition of cell surface mediated plasminogen activation by a monoclonal antibody against alpha-Enolase
    Roser Lopez-Alemany
    Centre d Oncologia Molecular C O M, Institut de Recerca Oncolgica IRO, Barcelona, Spain
    Am J Hematol 72:234-42. 2003
    ..These data suggest that, although leukocytic cells display several molecules that bind plasminogen, alpha-enolase is responsible for the majority of the promotion of plasminogen activation on the surfaces of leukocytic cells...
  19. ncbi Identification and validation of metastasis-associated proteins in head and neck cancer cell lines by two-dimensional electrophoresis and mass spectrometry
    Weiguo Wu
    Department of Thoracic Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Clin Exp Metastasis 19:319-26. 2002
    ..The results also suggest an important complementary role for proteomics in identification of molecular abnormalities important in cancer development and progression...
  20. ncbi Circulating autoantibodies to phosphorylated α-enolase are a hallmark of pancreatic cancer
    Barbara Tomaino
    Center for Experimental Research and Medical Studies CERMS, San Giovanni Battista Hospital, Turin, Italy
    J Proteome Res 10:105-12. 2011
    ..In conclusion, our results demonstrate that ENOA phosphorylation is associated with PDAC and induces specific autoantibody production in PDAC patients that may have diagnostic value...
  21. ncbi Extracellular proteins of Lactobacillus crispatus enhance activation of human plasminogen
    Veera Hurmalainen
    General Microbiology, Faculty of Biosciences, PO Box 56, FIN00014 University of Helsinki, Finland
    Microbiology 153:1112-22. 2007
    ..So far, interference with the Plg system has been addressed with pathogenic microbes. The results reported here demonstrate a novel interaction between a member of the microbiota and a major proteolytic system in humans...
  22. ncbi Proteomic identification of oxidatively modified proteins in Alzheimer's disease brain. Part II: dihydropyrimidinase-related protein 2, alpha-enolase and heat shock cognate 71
    Alessandra Castegna
    Department of Chemistry, Center of Membrane Sciences, University of Kentucky, Lexington, Kentucky 40506, USA
    J Neurochem 82:1524-32. 2002
    ..These results are discussed with reference to potential involvement of these oxidatively modified proteins in neurodegeneration in AD brain...
  23. ncbi Binding of Candida albicans enolase to plasmin(ogen) results in enhanced invasion of human brain microvascular endothelial cells
    Ambrose Y Jong
    Division of Hematology Oncology, Mailstop 57, Childrens Hospital Los Angeles, Los Angeles, CA 90027, USA
    J Med Microbiol 52:615-22. 2003
    ..The results given here indicate that Candida enolase is a plasminogen- and plasmin-binding protein and that the interaction of C. albicans enolase with the plasminogen system may contribute to invasion of the tissue barrier...
  24. pmc Glial loss in the prefrontal cortex is sufficient to induce depressive-like behaviors
    Mounira Banasr
    Laboratory of Molecular Psychiatry, Center for Genes and Behavior, Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06508, USA
    Biol Psychiatry 64:863-70. 2008
    ..However, it is unclear whether this glial loss plays a direct role in the expression of depressive symptoms...
  25. ncbi Decoding serological response to Candida cell wall immunome into novel diagnostic, prognostic, and therapeutic candidates for systemic candidiasis by proteomic and bioinformatic analyses
    Aida Pitarch
    Department of Microbiology II, Faculty of Pharmacy, Complutense University of Madrid, 28040 Madrid, Spain
    Mol Cell Proteomics 5:79-96. 2006
    ..Furthermore serum anti-wall enolase antibodies are a new prognostic indicator for SC and confer protection against it. Bgl2p and wall-associated enolase could be valuable candidates for future vaccine development...
  26. ncbi Neuronal activation of NF-kappaB contributes to cell death in cerebral ischemia
    Wen Zhang
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    J Cereb Blood Flow Metab 25:30-40. 2005
    ..In summary, the data show that NF-kappaB is activated in neurons and astrocytes during cerebral ischemia and that NF-kappaB activation in neurons contributes to the ischemic damage...
  27. ncbi Serum markers support disease-specific glial pathology in major depression
    Matthias L Schroeter
    Queen Elisabeth Hospital, Department of Psychiatry, 10362 Berlin, Germany
    J Affect Disord 111:271-80. 2008
    ..Recently, it was shown by histopathological studies that mood disorders are characterized by disease-specific glial pathology...
  28. ncbi Alpha-enolase: a target of antibodies in infectious and autoimmune diseases
    Benjamin Terrier
    Paris Descartes University, Faculty of Medicine, UPRES EA 4058, Paris, France
    Autoimmun Rev 6:176-82. 2007
    ..However, further studies are needed to improve our knowledge on the pathogenic role of these Abs...
  29. ncbi Glioma cell populations grouped by different cell type markers drive brain tumor growth
    Lars Prestegarden
    Oncomatrix Research Lab, Department of Biomedicine and Norlux Neuro Oncology, Department of Biomedicine, University of Bergen, Bergen, Norway
    Cancer Res 70:4274-9. 2010
    ..These findings suggest that the ability to form tumors may be a general trait associated with different glioma cell phenotypes, rather than a property limited to an exclusive subpopulation of glioma stem cells...
  30. ncbi Multiple antibody reactivities to citrullinated antigens in sera from patients with rheumatoid arthritis: association with HLA-DRB1 alleles
    O Snir
    Department of Medicine, Rheumatology Unit, Karolinska University Hospital, Karolinska Institute, Solna, Stockholm, Sweden
    Ann Rheum Dis 68:736-43. 2009
    ..Autoantibodies to cyclic citrullinated peptides (anti-CCP) are present in most patients with rheumatoid arthritis (RA), and associate with HLA-DRB1 shared epitope (SE) alleles...
  31. ncbi Oxidative stress parameters in unmedicated and treated bipolar subjects during initial manic episode: a possible role for lithium antioxidant effects
    Rodrigo Machado-Vieira
    Mood Disorders Program, HMIPV, Fundacao Faculdade Federal Ciencias Medicas de Porto Alegre and Bipolar Disorder Research Program, Espirita Hospital of Porto Alegre, Porto Alegre, Brazil
    Neurosci Lett 421:33-6. 2007
    ..Antioxidant effects using lithium in mania were shown, and further studies are necessary to evaluate the potential role of these effects in the pathophysiology and therapeutics of BD...
  32. pmc Circulating antibodies against alpha-enolase in patients with primary membranous nephropathy (MN)
    H Wakui
    Third Department of Internal Medicine, Akita University School of Medicine, Akita, Japan
    Clin Exp Immunol 118:445-50. 1999
    ....
  33. ncbi An increase in S-glutathionylated proteins in the Alzheimer's disease inferior parietal lobule, a proteomics approach
    Shelley F Newman
    Department of Chemistry, University of Kentucky, Lexington, Kentucky 40506, USA
    J Neurosci Res 85:1506-14. 2007
    ..This study demonstrates that specific proteins are sensitive to S-glutathionylation, which most likely is due to their sensitivity to cysteine oxidation initiated by the increase in oxidative stress in the AD brain...
  34. ncbi Identification of enolase as a laminin-binding protein on the surface of Staphylococcus aureus
    Celia R W Carneiro
    Discipline of Immunology, Microbiology, Immunology and Parasitology Department, Federal University of Sao Paulo, Sao Paulo, Brazil
    Microbes Infect 6:604-8. 2004
    ..aureus alpha-enolase was further confirmed by flow cytometry. Hence, alpha-enolase might play a critical role in the pathogenesis of S. aureus by allowing its adherence to laminin-containing extracellular matrix...
  35. ncbi The nine residue plasminogen-binding motif of the pneumococcal enolase is the major cofactor of plasmin-mediated degradation of extracellular matrix, dissolution of fibrin and transmigration
    Simone Bergmann
    Research Center for Infectious Diseases, University of Wurzburg, Germany
    Thromb Haemost 94:304-11. 2005
    ....
  36. ncbi Presence of autoantibodies to the glycolytic enzyme alpha-enolase in sera from patients with early rheumatoid arthritis
    Vincent Saulot
    Institut National de la Sante et de la Recherche Medicale, Rouen, France
    Arthritis Rheum 46:1196-201. 2002
    ..To identify a new autoantigen/autoantibody population in rheumatoid arthritis (RA) sera...
  37. pmc Increased cerebrospinal fluid and serum levels of S100B in first-onset schizophrenia are not related to a degenerative release of glial fibrillar acidic protein, myelin basic protein and neurone-specific enolase from glia or neurones
    J Steiner
    Department of Psychiatry, University of Magdeburg, Leipziger Strasse 44, D 39120 Magdeburg, Germany
    J Neurol Neurosurg Psychiatry 77:1284-7. 2006
    ..To assess levels of glial fibrillar acidic protein (GFAP), myelin basic protein (MBP), neurone-specific enolase (NSE) and S100B in patients with first-onset schizophrenia...
  38. pmc Immunogenic and plasminogen-binding surface-associated alpha-enolase of Trichomonas vaginalis
    V Mundodi
    Department of Microbiology and Immunology, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    Infect Immun 76:523-31. 2008
    ..These data indicate that as with other bacterial pathogens, tv-ENO1 is an anchorless, surface-associated glycolytic enzyme of T. vaginalis...
  39. ncbi alpha-enolase, a novel strong plasmin(ogen) binding protein on the surface of pathogenic streptococci
    V Pancholi
    Laboratory of Bacterial Pathogenesis and Immunology, The Rockefeller University, New York, New York 10021, USA
    J Biol Chem 273:14503-15. 1998
    ..Our findings, showing both the protected protease activity of SEN-bound plasmin and SEN-specific immune responses, provide evidence for an important role of SEN in the disease process and post-streptococcal autoimmune diseases...
  40. ncbi Generation and characterization of anti-alpha-enolase single-chain antibodies in chicken
    Sy Jye Leu
    Department of Microbiology and Immunology, School of Medicine, Taipei Medical University, Taipei 110, Taiwan
    Vet Immunol Immunopathol 137:251-60. 2010
    ..All together, it is believed that these polyclonal and scFv IgY antibodies may be helpful in the development of molecular diagnostic and therapeutic agents for lung cancers in the future...
  41. pmc Serum levels of S100B and NSE proteins in Alzheimer's disease patients
    Marcia L Chaves
    Servico de Neurologia, Hospital de Clinicas de Porto Alegre, Rua Ramiro Barcelos 2350, 90035 003 Porto Alegre, RS, Brazil
    J Neuroinflammation 7:6. 2010
    ..Alzheimer's disease is the most common dementia in the elderly, and the potential of peripheral biochemical markers as complementary tools in the neuropsychiatric evaluation of these patients has claimed further attention...
  42. ncbi Antibodies to several citrullinated antigens are enriched in the joints of rheumatoid arthritis patients
    Omri Snir
    Karolinska University Hospital, Karolinska Institutet at Solna, Stockholm, Sweden
    Arthritis Rheum 62:44-52. 2010
    ..Furthermore, we studied their relationships with mutated citrullinated vimentin (MCV), a newly identified RA-specific serum assay, and the classic cyclic citrullinated peptide (CCP) in the synovial fluid of well-defined HLA-DR groups...
  43. pmc A new nuclear function of the Entamoeba histolytica glycolytic enzyme enolase: the metabolic regulation of cytosine-5 methyltransferase 2 (Dnmt2) activity
    Ayala Tovy
    Department of Molecular Microbiology, The Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel
    PLoS Pathog 6:e1000775. 2010
    ..histolytica expressing a nuclear localization signal (NLS)-fused-enolase. These results establish enolase as the first Dnmt2 interacting protein, and highlight an unexpected role of a glycolytic enzyme in the modulation of Dnmt2 activity...
  44. pmc Paracoccidioides brasiliensis enolase is a surface protein that binds plasminogen and mediates interaction of yeast forms with host cells
    Sarah Veloso Nogueira
    Laboratorio de Biologia Molecular, Instituto de Ciencias Biologicas, ICBII, Campus II, Universidade Federal de Goias, 74001 970, Goiania, Goias, Brazil
    Infect Immun 78:4040-50. 2010
    ..The expression of PbEno was upregulated in yeast cells derived from mouse-infected tissues. These data indicate that surface-associated PbEno may contribute to the pathogenesis of P. brasiliensis...
  45. ncbi Direct characterization of target podocyte antigens and auto-antibodies in human membranous glomerulonephritis: Alfa-enolase and borderline antigens
    Maurizio Bruschi
    Division of Nephrology and Laboratory on Pathophysiology of Uremia, G Gaslini Children Hospital, Genoa, Italy
    J Proteomics 74:2008-17. 2011
    ..Circulating anti α-enolase auto-antibodies can be detected in sera of a significant quota of MGN patients. Like other auto-antigens, α-enolase may be implicated in the pathogenesis of human MGN...
  46. ncbi α-Enolase expressed on the surfaces of monocytes and macrophages induces robust synovial inflammation in rheumatoid arthritis
    Seyeon Bae
    Department of Anatomy, Seoul National University College of Medicine, Seoul 110 799, Republic of Korea
    J Immunol 189:365-72. 2012
    ....
  47. pmc Plasmodium ookinetes coopt mammalian plasminogen to invade the mosquito midgut
    Anil K Ghosh
    Department of Molecular Microbiology and Immunology, Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 108:17153-8. 2011
    ....
  48. ncbi Antibodies to citrullinated α-enolase peptide 1 and clinical and radiological outcomes in rheumatoid arthritis
    Benjamin A Fisher
    Kennedy Institute of Rheumatology, Imperial College London, UK
    Ann Rheum Dis 70:1095-8. 2011
    ..The anti-CEP-1 positive subset is strongly associated with the HLA-DRB1 shared epitope and its interaction with smoking...
  49. ncbi Anti-alpha-enolase antibodies in patients with inflammatory Bowel disease
    Nathalie Vermeulen
    Department of Internal Medicine, University Hospital Leuven, Leuven, Belgium
    Clin Chem 54:534-41. 2008
    ..alpha-Enolase has been proposed as a target antigen in IBD. We evaluated the prevalence and diagnostic value of anti-alpha-enolase antibodies in IBD and related disorders...
  50. ncbi Proteomics characterization of gastrokine 1-induced growth inhibition of gastric cancer cells
    Guang Rong Yan
    Institute of Life and Health Engineering and National Engineering and Research Center for Genetic Medicine, Jinan University, Guangzhou, P R China
    Proteomics 11:3657-64. 2011
    ..These observations suggested that ENO1 downregulation played an important role in GKN1-induced growth inhibition of gastric cancer cells...
  51. ncbi Oxidative and nitrative modifications of alpha-enolase in cardiac proteins from diabetic rats
    Naihao Lu
    Department of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan, People s Republic of China
    Free Radic Biol Med 48:873-81. 2010
    ..Meanwhile, the up-regulation of alpha-enolase expression could be a protective mechanism to neutralize oxidative and nitrative stress in diabetes...
  52. pmc Lateral transfer at the gene and subgenic levels in the evolution of eukaryotic enolase
    P J Keeling
    Department of Biology, Indiana University, Bloomington, IN 47405, USA
    Proc Natl Acad Sci U S A 98:10745-50. 2001
    ....
  53. ncbi Enhanced activation of bound plasminogen on Staphylococcus aureus by staphylokinase
    Tomi Mölkänen
    Department of Bacteriology and Immunology, The Haartman Institute, FIN 00014 University of Helsinki, Helsinki, Finland
    FEBS Lett 517:72-8. 2002
    ....
  54. ncbi Enolase isoenzymes. III. Chromatographic and immunological characteristics of rat brain enolase
    L Fletcher
    Biochim Biophys Acta 452:245-52. 1976
    ..5. It is therefore concluded that there are three genetic loci alpha, beta and gamma, coding for the enolase isoenzymes of rat tissues...
  55. pmc Erythropoietin promotes neurovascular remodeling and long-term functional recovery in rats following traumatic brain injury
    Ruizhuo Ning
    Department of Neurosurgery, Henry Ford Health System, Detroit, MI 48202, USA
    Brain Res 1384:140-50. 2011
    ..In conclusion, the beneficial effects of posttraumatic EPO treatment on injured brain persisted for at least 3 months. The long-term improvement in functional outcome may in part be related to the neurovascular remodeling induced by EPO...
  56. ncbi Differential modulation of alpha, beta and gamma enolase isoforms in regenerating mouse skeletal muscle
    T Merkulova
    CNRS UPR 9065, College de France, Paris, France
    Eur J Biochem 267:3735-43. 2000
    ..Double labeling experiments with anti-gamma enolase and FITC-alpha bungarotoxin allowed us to follow the neuromuscular junction remodeling that occurs during muscle regeneration despite the absence of nerve injury...
  57. ncbi Multifunctional roles of enolase in Alzheimer's disease brain: beyond altered glucose metabolism
    D Allan Butterfield
    Department of Chemistry, University of Kentucky, Lexington, Kentucky 40506 0055, USA
    J Neurochem 111:915-33. 2009
    ..This review examines potential altered function(s) of brain enolase in MCI, early-onset AD, and AD, alterations that may contribute to the biochemical, pathological, clinical characteristics, and progression of this dementing disorder...
  58. ncbi Elevated serum neuron-specific enolase in patients with temporal lobe epilepsy: a video-EEG study
    Johanna Palmio
    Department of Neurology, University of Tampere, FIN 33014 Tampere, Finland
    Epilepsy Res 81:155-60. 2008
    ..4). The levels of markers of neuronal damage were increased in patients with TLE, not only after tonic-clonic but also after complex partial seizures. These data suggest that TLE may be associated with brain damage...
  59. ncbi Synovial fluid is a site of citrullination of autoantigens in inflammatory arthritis
    Andrew Kinloch
    Imperial College London, London, UK
    Arthritis Rheum 58:2287-95. 2008
    ..To examine synovial fluid as a site for generating citrullinated antigens, including the candidate autoantigen citrullinated alpha-enolase, in rheumatoid arthritis (RA)...
  60. ncbi Normal CSF neuron-specific enolase and S-100 protein levels in patients with recent non-complicated tonic-clonic seizures
    J Palmio
    Department of Neurology, Tampere University Hospital, P O Box 2000, FIN 33521, Tampere, Finland
    J Neurol Sci 183:27-31. 2001
    ..Because larger studies addressing cerebrospinal fluid (CSF) levels of NSE or S-100 have not been performed, we measured CSF NSE and S-100 after tonic-clonic seizures to search for evidence of neuronal and glial damage...
  61. ncbi Glycolysis and rheumatoid arthritis
    Xiaotian Chang
    Key Laboratory for Bio Drugs of Ministry of Health, Provincial Laboratory for Bio Drugs of Ministry of Health, Research Center for Medicinal Biotechnology, Shandong Academy of Medical Sciences, Jinan, Shandong, China
    Int J Rheum Dis 14:217-22. 2011
    ..Lactate and pyruvate, substrates of RA synovium metabolism, stimulate abnormal cell proliferation, angiogenesis and pannus formation...
  62. ncbi Cisternal S100 protein and neuron-specific enolase are elevated and site-specific markers in intractable temporal lobe epilepsy
    B J Steinhoff
    Department of Clinical Neurophysiology, Zentrum Neurologische Medizin, Georg August Universitat, Gottingen, Germany
    Epilepsy Res 36:75-82. 1999
    ..We conclude that interictal temporal lobe dysfunction corresponds with neuronal and glial marker elevations in the extracellular space and that site-specific elevations may predict the site of seizure origin biochemically...
  63. pmc Validating serum S100B and neuron-specific enolase as biomarkers for the human brain - a combined serum, gene expression and MRI study
    Daniel Paolo Streitbürger
    Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany
    PLoS ONE 7:e43284. 2012
    ..Neuron-specific enolase (NSE) is a specific serum marker for neuronal damage. However, the specificity of these biomarkers for cell type and brain region has not been investigated in vivo until now...
  64. ncbi Plasmin(ogen)-binding alpha-enolase from Streptococcus pneumoniae: crystal structure and evaluation of plasmin(ogen)-binding sites
    Stefanie Ehinger
    Division of Structural Biology, GBF German Research Center for Biotechnology, Mascheroder Weg 1, 38124 Braunschweig, Germany
    J Mol Biol 343:997-1005. 2004
    ..The nine residue plasminogen-binding motif, by contrast, is exposed on the octamer surface revealing this as the primary site of interaction between alpha-enolase and plasminogen...
  65. ncbi Plasminogen-mediated group A streptococcal adherence to and pericellular invasion of human pharyngeal cells
    Vijay Pancholi
    Laboratory of Bacterial Pathogenesis, Public Health Research Institute, The International Center for Public Health, 225 Warren Street, W450T, Newark, NJ 07103 3535, USA
    Microb Pathog 35:293-303. 2003
    ....
  66. ncbi alpha-Enolase of Streptococcus pneumoniae is a plasmin(ogen)-binding protein displayed on the bacterial cell surface
    S Bergmann
    Department of Microbial Pathogenicity, GBF German Research Centre for Biotechnology, Mascheroder Weg 1, D 38124 Braunschweig, Germany
    Mol Microbiol 40:1273-87. 2001
    ..The reassociation was also confirmed by immunoelectron microscopy. The results suggest a mechanism of plasminogen activation for human pathogens that might contribute to their virulence potential in invasive infectious processes...
  67. ncbi Plasminogen binding by oral streptococci from dental plaque and inflammatory lesions
    Bertil Kinnby
    Department of Oral Biology, Malmo University, S 20506 Malmö, Sweden
    Microbiology 154:924-31. 2008
    ..The findings illustrate how apparently innocuous commensal bacteria are capable of utilizing a mechanism that is generally regarded as being of importance to pathogenicity and suggest an additional role of plasminogen binding...
  68. ncbi Evidence for nuclear localisation of two stage-specific isoenzymes of enolase in Toxoplasma gondii correlates with active parasite replication
    David J P Ferguson
    Nuffield Department of Pathology, John Radcliffe Hospital, University of Oxford, OX3 9DU, Oxford
    Int J Parasitol 32:1399-410. 2002
    ....
  69. ncbi Repeated restraint stress suppresses neurogenesis and induces biphasic PSA-NCAM expression in the adult rat dentate gyrus
    Kara Pham
    Laboratory of Neuroendocrinology, Rockefeller University, New York, New York 10021, USA
    Eur J Neurosci 17:879-86. 2003
    ..These studies may help us understand the basis for hippocampal shrinkage and raise questions about the ultimate reversibility of the effects of chronic stress...
  70. ncbi Tumor markers in neuroendocrine tumors
    B Eriksson
    Section for Endocrine Oncology, Department of Medical Sciences, University Hospital, Uppsala, Sweden
    Digestion 62:33-8. 2000
    ..Chromogranin A serum or plasma levels reflect tumor load, and it may be an independent marker of prognosis in patients with midgut carcinoids...
  71. ncbi Predictive power of serum NSE and OHCA score regarding 6-month neurologic outcome after out-of-hospital ventricular fibrillation and therapeutic hypothermia
    Tuomas Oksanen
    Department of Anaesthesiology and Intensive Care Medicine, Helsinki University Hospital, Finland
    Resuscitation 80:165-70. 2009
    ....
  72. ncbi Enolase takes part in a macromolecular complex associated to mitochondria in yeast
    Irina Brandina
    UMR 7156 Génétique Moléculaire, Génomique et Microbiologie CNRS, Université Louis Pasteur Strasbourg I Institut de Physiologie et Chimie Biologique, 21 rue René Descartes, 67084 Strasbourg, France
    Biochim Biophys Acta 1757:1217-28. 2006
    ..This suggests an unsuspected novel function for this complex in tRNA mitochondrial import...
  73. ncbi Structure of the human gene for alpha-enolase
    A Giallongo
    Istituto di Biologia dello Sviluppo del Consiglio Nazionale delle Ricerche, Palermo, Italy
    Eur J Biochem 190:567-73. 1990
    ..Furthermore, various sequences similar to known regulatory elements were detected...
  74. ncbi Turning blood into brain: cells bearing neuronal antigens generated in vivo from bone marrow
    E Mezey
    Basic Neuroscience Program, Laboratory of Developmental Neurogenetics, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Science 290:1779-82. 2000
    ..These findings raise the possibility that bone marrow-derived cells may provide an alternative source of neurons in patients with neurodegenerative diseases or central nervous system injury...
  75. ncbi Prediction of short-term and long-term outcomes after cardiac arrest: a prospective multivariate approach combining biochemical, clinical, electrophysiological, and neuropsychological investigations
    Jörn Prohl
    Department of Biological Psychology and Neuropsychology, University of Hamburg, Germany
    Crit Care Med 35:1230-7. 2007
    ..To determine the prognostic accuracy of biochemical, clinical, electrophysiological, and neuropsychological investigations in predicting outcomes after cardiac arrest...
  76. ncbi Serum biomarker concentrations and outcome after pediatric traumatic brain injury
    Rachel Pardes Berger
    Department of Pediatrics, Division of Child Advocacy, Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Safar Center for Resuscitation Research, Pittsburgh, Pennsylvania 15213, USA
    J Neurotrauma 24:1793-801. 2007
    ..Future studies should focus on assessing the differential benefit of biomarkers compared with clinical variables and in assessing a continuous rather than categorical outcome variable...
  77. ncbi S100B and NSE serum levels in patients with Parkinson's disease
    Débora V Schaf
    Departamento de Bioquimica, ICBS, UFRGS, Ramiro Barcelos 2600 anexo, 90035 003 Porto Alegre, RS, Brazil
    Parkinsonism Relat Disord 11:39-43. 2005
    ..006). Therefore, S100B and NSE may not have a diagnostic role in PD, but S100B may have a potential role as a marker of disease progression. The study of S100B may also contribute to elucidate the controversial role of glial cells in PD...
  78. ncbi Neuron-specific apolipoprotein e4 proteolysis is associated with increased tau phosphorylation in brains of transgenic mice
    Walter J Brecht
    Gladstone Institute of Neurological Disease, San Francisco, California 94141 9100, USA
    J Neurosci 24:2527-34. 2004
    ..Neuron-specific proteolytic cleavage of apoE4 is associated with increased phosphorylation of tau and may play a key role in the development of AD-related neuronal deficits...
  79. pmc The central nucleus of the amygdala and corticotropin-releasing factor: insights into contextual fear memory
    Matthew W Pitts
    Department of Cell and Molecular Biology, John A Burns School of Medicine, University of Hawaii, Honolulu, Hawaii 96813, USA
    J Neurosci 29:7379-88. 2009
    ..Collectively, our results suggest CeA involvement in the consolidation of contextual fear memory and specifically implicate CeA CRF as an important mediator...
  80. ncbi ENO1 gene product binds to the c-myc promoter and acts as a transcriptional repressor: relationship with Myc promoter-binding protein 1 (MBP-1)
    S Feo
    Dipartimento di Biologia Cellulare e dello Sviluppo, Universita di Palermo, Viale delle Scienze, Parco d Orleans, 90128, Palermo, Italy
    FEBS Lett 473:47-52. 2000
    ....
  81. ncbi Anti-enolase-alpha autoantibodies in cancer-associated retinopathy: epitope mapping and cytotoxicity on retinal cells
    G Adamus
    Neurological Sciences Institute, Oregon Health Sciences University, 1120 NW 20th Ave, Portland, OR, USA
    J Autoimmun 11:671-7. 1998
    ..These studies showed that anti-enolase antibodies from patients with CAR were able to induce apoptotic cell death in E1A.NR3 retinal cells and provided a potential mechanism for retinal degeneration in humans...
  82. ncbi In vitro differentiation of human marrow stromal cells into early progenitors of neural cells by conditions that increase intracellular cyclic AMP
    W Deng
    Center for Gene Therapy, Tulane University Health Sciences Center, SL-99, 1430 Tulane Avenue, New Orleans, Louisiana, 70112, USA
    Biochem Biophys Res Commun 282:148-52. 2001
    ..The data suggested that the hMSCs may have been differentiated into early progenitors of neural cells in vitro under conditions that increase the intracellular level of cAMP...
  83. ncbi Cathepsin X cleaves the C-terminal dipeptide of alpha- and gamma-enolase and impairs survival and neuritogenesis of neuronal cells
    Natasa Obermajer
    University of Ljubljana, Faculty of Pharmacy, Ljubljana, Slovenia
    Int J Biochem Cell Biol 41:1685-96. 2009
    ..On the other hand, the proliferation of cells is decreased, indicating induction of differentiation. Our study reveals enolase isozymes as crucial neurotrophic factors that are regulated by the proteolytic activity of cathepsin X...
  84. ncbi Oxidative stress-induced proteome alterations target different cellular pathways in human myoblasts
    Martin A Baraibar
    Laboratoire de Biologie Cellulaire du Vieillissement, UR4, Universite Pierre et Marie Curie Paris 6, 75252 Paris Cedex 05, France
    Free Radic Biol Med 51:1522-32. 2011
    ..This study emphasizes the importance of performing analysis addressing different aspects of the cellular proteome to have a more accurate view of their changes upon stress...
  85. ncbi Multifunctional alpha-enolase: its role in diseases
    V Pancholi
    Laboratory of Bacterial Pathogenesis and Immunology, The Rockefeller University, New York, NewYork 10021, USA
    Cell Mol Life Sci 58:902-20. 2001
    ..In addition to this property, its ability to function as a heat-shock protein and to bind cytoskeletal and chromatin structures indicate that enolase may play a crucial role in transcription and a variety of pathophysiological processes...
  86. ncbi Non-neuronal enolase is an endothelial hypoxic stress protein
    R M Aaronson
    Pulmonary Center, Boston University School of Medicine, Massachusetts 02118, USA
    J Biol Chem 270:27752-7. 1995
    ..4-fold. While hypoxic up-regulation of NNE may have a protective effect by augmenting anaerobic metabolism, we speculate that enolase may contribute to EC hypoxia tolerance through one or more of its nonglycolytic functions...
  87. ncbi Retinoic acid-mediated down-regulation of ENO1/MBP-1 gene products caused decreased invasiveness of the follicular thyroid carcinoma cell lines
    Bogusz Trojanowicz
    AG Experimentelle and Chirurgische Onkologie, Universitätsklinik und Poliklinik für Allgemein, Viszeral und Gefässchirurgie, Martin Luther Universitat, Halle S, Germany
    J Mol Endocrinol 42:249-60. 2009
    ....
  88. ncbi Diagnostic detection of human lung cancer-associated antigen using a gold nanoparticle-based electrochemical immunosensor
    Ja An Annie Ho
    Bioanalytical Laboratory, Department of Chemistry, National Tsing Hua University, Hsinchu 300, Taiwan
    Anal Chem 82:5944-50. 2010
    ..This AuNP congregate-based assay provides an amplification approach for detecting ENO1 at trace levels, leading to a detection limit as low as 11.9 fg (equivalent to 5 microL of a 2.38 pg/mL solution)...
  89. ncbi Cloning and characterization of a plasminogen-binding surface-associated enolase from Schistosoma bovis
    Eduardo de la Torre-Escudero
    Parasitology Laboratory, Instituto de Recursos Naturales y Agrobiología de Salamanca IRNASA, CSIC, Cordel de Merinas, 40 52, 37008 Salamanca, Spain
    Vet Parasitol 173:76-84. 2010
    ....
  90. ncbi Neuron-specific enolase correlates with other prognostic markers after cardiac arrest
    T Cronberg
    Division of Neurology, Department of Clinical Sciences, Skane University Hospital, Lund University, Lund, Sweden
    Neurology 77:623-30. 2011
    ..This prospective, observational study describes the pattern of commonly used prognostic markers in a hypothermia-treated cohort of cardiac arrest patients with prolonged coma...
  91. ncbi Targeted deletion of a yeast enolase structural gene. Identification and isolation of yeast enolase isozymes
    L McAlister
    J Biol Chem 257:7181-8. 1982
    ....
  92. ncbi Plasminogen/plasmin regulates alpha-enolase expression through the MEK/ERK pathway
    Lirlandia P Sousa
    Grupo de Transdução de Sinal, Departamento de Microbiologia, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, 31270 901 Belo Horizonte, Minas Gerais, Brazil
    Biochem Biophys Res Commun 337:1065-71. 2005
    ..Altogether, our data show that Plg/Pla regulates alpha-ENO expression through the MEK/ERK pathway...
  93. pmc pH-dependent association of enolase and glyceraldehyde-3-phosphate dehydrogenase of Lactobacillus crispatus with the cell wall and lipoteichoic acids
    Jenni Antikainen
    General Microbiology, Faculty of Biosciences, P O Box 56, FIN 00014 University of Helsinki, Finland
    J Bacteriol 189:4539-43. 2007
    ..These proteins bound to lipoteichoic acids at a pH below their isoelectric point. The results indicate that lactobacilli rapidly modify their surface properties in response to changes in pH...
  94. pmc Catalase and alpha-enolase: two novel granulocyte autoantigens in inflammatory bowel disease (IBD)
    C Roozendaal
    Department of Clinical Immunology, University Hospital, Groningen, The Netherlands
    Clin Exp Immunol 112:10-6. 1998
    ..This study is the first to report catalase and alpha-enolase as granulocyte antigens for autoantibodies in IBD...
  95. ncbi Molecular evolution of enolase
    Michał Piast
    Department of Medical Biochemistry, Wrocław Medical University, Wrocław, Poland
    Acta Biochim Pol 52:507-13. 2005
    ..Tolerated substitutions occur most frequently in alpha-enolase, while the lowest number of substitutions has accumulated in gamma-enolase, which may suggest that it is the most recently evolved isoenzyme of enolase in vertebrates...
  96. ncbi S-100B is superior to NSE, BDNF and GFAP in predicting outcome of resuscitation from cardiac arrest with hypothermia treatment
    Erik Mörtberg
    Department of Surgical Sciences, Anaesthesia and Intensive Care, Uppsala University, Uppsala University Hospital, Uppsala, Sweden
    Resuscitation 82:26-31. 2011
    ....
  97. pmc Hypoxia induces differential translation of enolase/MBP-1
    Kara C Sedoris
    James Graham Brown Cancer Center, Department of Medicine, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
    BMC Cancer 10:157. 2010
    ..We have previously shown that MBP-1 and its binding to the c-myc P2 promoter regulates the metabolic and cellular growth changes that occur in response to altered exogenous glucose concentrations...
  98. ncbi Can monomers of yeast enolase have enzymatic activity?
    M J Kornblatt
    Department of Chemistry and Biochemistry, Concordia University, Montreal, Quebec, Canada
    Eur J Biochem 251:775-80. 1998
    ..The precise conformation of these, loops is necessary for binding Mg2+ (and, hence, for activity) and for maintaining subunit interactions...
  99. ncbi Neuron specific enolase and S-100B as predictors of outcome after cardiac arrest and induced hypothermia
    Malin Rundgren
    Department of Anaesthesia and Intensive Care, Lund University Hospital, Sweden
    Resuscitation 80:784-9. 2009
    ..To assess the prognostic value of repetitive serum samples of neuron specific enolase (NSE) and S-100B in cardiac arrest patients treated with hypothermia...
  100. pmc SEDLIN forms homodimers: characterisation of SEDLIN mutations and their interactions with transcription factors MBP1, PITX1 and SF1
    Jeshmi Jeyabalan
    Academic Endocrine Unit, Nuffield Department of Clinical Medicine, Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, United Kingdom
    PLoS ONE 5:e10646. 2010
    ..SEDLIN mutations cause X-linked spondyloepiphyseal dysplasia tarda (SEDT)...
  101. ncbi Cytokine-induced stable neuronal differentiation of human bone marrow mesenchymal stem cells in a serum/feeder cell-free condition
    Helen Tao
    Department of Haematology and Haemopoietic Stem Cell Transplantation, St Vincent s Hospital Sydney, New South Wales, Australia
    Dev Growth Differ 47:423-33. 2005
    ..Our results show that MSC isolated by two different procedures produced identical lineage differentiation with defined growth factors in a serum- and feeder cell-free condition...

Research Grants65

  1. GENOMIC ENZYMOLOGY: THE CROTONASE SUPERFAMILY
    JOHN GERLT; Fiscal Year: 2003
    ..5) 3-OH Isobutyryl CoA hydrolase (HIBCH) catalyzes hydrolysis of a thioester in valine catabolism. We will study HIBCH so that we can determine whether the reaction proceeds via and enolate anion or an anionic tetrahedral intermediate. ..
  2. GENOMIC ENZYMOLOGY: THE ENOLASE SUPERFAMILY
    JOHN GERLT; Fiscal Year: 2006
    ..4) We will test a structural blueprint for functional diversity in the (beta/alpha)7beta-barrel fold by determining whether new functions can be generated by in vitro evolution. ..
  3. Aging as a risk factor for seizure-induced cell death
    PAULA SCHAUWECKER; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  4. Genetic Regulation of Seizure-Induced Neurogenesis
    PAULA SCHAUWECKER; Fiscal Year: 2004
    ..abstract_text> ..
  5. Signal Transduction Mechanisms in Suicide Brain
    Yogesh Dwivedi; Fiscal Year: 2008
    ..abstract_text> ..
  6. POSTRECEPTOR DYSREGULATION IN DEPRESSION
    Yogesh Dwivedi; Fiscal Year: 2004
    ..abstract_text> ..
  7. Validating microRNA Analysis in Human Postmortem Brain
    Yogesh Dwivedi; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  8. Epileptogenicity in the Developing Brain
    Raman Sankar; Fiscal Year: 2007
    ..Our findings will provide the basis for future neuroprotective interventions targeting the developing brain at different stages of status epilepticus in order to interrupt the course of the epileptogenic process. ..
  9. Synaptosomal Protein Changes After EtOH Self-Administration
    Frank Witzmann; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  10. Novel Immunological Modifer as a Tissue Protector
    MICHAEL VITEK; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  11. Androgens and apoE4 induced cognitive impairments
    Jacob Raber; Fiscal Year: 2005
    ....
  12. Mitochondrial Dysfunction in Pediatric Head Injury
    Courtney Robertson; Fiscal Year: 2006
    ..abstract_text> ..
  13. Interleukin-1 and Memory Loss in Aging
    Carmelina Gemma; Fiscal Year: 2006
    ....
  14. BACKTRACKING TRANSLOCATIONS IN CHILDHOOD LEUKEMIA
    Joseph Wiemels; Fiscal Year: 2006
    ..We are ultimately working to elucidate the origin and causes of a cancer that might be preventable. [unreadable] [unreadable]..
  15. NOVEL INHIBITORS OF BRAIN ISCHEMIA
    MICHAEL VITEK; Fiscal Year: 2003
    ..In Phase I, we will measure the effect of treatment with synthetic KPI domain to reduce fibrin deposition and improve behavioral performance in a mouse model for focal ischemic injury. ..
  16. Novel Intervention for Colitis
    MICHAEL VITEK; Fiscal Year: 2007
    ..So we propose to directly measure whether COG112 will exacerbate or ameliorate colitis in mouse models. [unreadable] [unreadable] [unreadable]..
  17. PI and Wnt Signaling in Postmortem Brain of Biopolar and Schizophrenia Subjects
    Ghanshyam N Pandey; Fiscal Year: 2011
    ..This may eventually lead to i better understanding of the pathophysiology of BP or SZ illnesses and may aid in the development of more appropriate therapeutic agents for the treatment of these disorders. ..
  18. Protein Biomarker Profiles of Abusive Alcohol Consumption
    Frank Witzmann; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  19. Prenatal Virally Induced Brain Disorder in Mouse
    SEYYED FATEMI; Fiscal Year: 2009
    ..In addition, it is expected that the results will provide clues that will lead to fundamental advances in our knowledge of the pathogenesis of schizophrenia and, therefore, of how it can be prevented and treated. ..
  20. Dispersion Patterns for Retinal Neuroblasts
    BENJAMIN REESE; Fiscal Year: 2009
    ..abstract_text> ..
  21. Varenicline and Smoking Cessation in Schizophrenia
    SEYYED HOSSEIN FATEMI; Fiscal Year: 2010
    ..Such outcomes will be significant, because they will offer a new treatment for smoking cessation in this vulnerable population. ..
  22. COMPLEMENT-MEDIATED NEURONAL INJURY IN STROKE
    EDWARD SANDER CONNOLLY; Fiscal Year: 2010
    ....
  23. Meningioma: Risk Factors and Quality of Life
    JOSEPH LEO WIEMELS; Fiscal Year: 2010
    ..This study represents the first concentrated effort to examine environmental and genetic risk factors for meningioma. ..
  24. Mouse models for GABA epigenetic dysfunction
    Alessandro Guidotti; Fiscal Year: 2009
    ..abstract_text> ..
  25. Invasion of C. neoformans into brain endothelial cells
    Ambrose Jong; Fiscal Year: 2008
    ..The information derived from the studies is expected to be helpful in the development of novel strategies to prevent cryptococcal meningitis and its associated morbidity. ..
  26. TRAUMATIC BRAIN INJURY AND MARROW STROMAL CELLS
    Asim Mahmood; Fiscal Year: 2009
    ..If the treatment combining MSCs with simvastatin is found to be more effective than monotherapy, this will increase the clinical relevance of MSC treatment by allowing us to use smaller and safer doses. ..
  27. Motherhood and Structural Plasticity in the Hippocampus
    Benedetta Leuner; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  28. ENERGY METABOLISM, DOPAMINE NEURONS AND NEUROTOXICITY
    Gail Zeevalk; Fiscal Year: 2008
    ..The studies will have relevance to neurodegenerative conditions or pathophysiological situations in which metabolism is compromised. ..
  29. Rapid seizure-induced changes in dendritic spines
    Michael Wong; Fiscal Year: 2007
    ..Washington University possesses unmatched resources in cutting-edge technology and expert researchers in cellular imaging and represents an ideal environment for the PI to complete the goals of this proposal. ..
  30. Triple Transgenic Model of Alzheimer's Disease
    MICHAEL VITEK; Fiscal Year: 2006
    ....
  31. Olympus FV 1000 Confocal Microscope for Neurobiology and Cellular Biology Researc
    Francisco Alvarez; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  32. ANIMAL MODEL OF ALZHEIMERS DISEASE PATHOLOGY
    MICHAEL VITEK; Fiscal Year: 2001
    ..Should this be insufficient to produce PHF/NFT pathology, we will stress these animals in a variety of ways to predispose the formation and detection of PHF/NFT structures (Specific Aim 4). ..
  33. Microarrays for Alzheimer's Disease Mouse Models
    P Reddy; Fiscal Year: 2003
    ..The outcome of this proposed investigation will be useful in screening several mitochondrial antioxidants in AD transgenic mouse models as pre-clinical trials of AD patients...
  34. MEDIC ONE STROKE SCALE
    David Tirschwell; Fiscal Year: 2003
    ..As stroke therapeutic research moves into the prehospital setting, the MOSS will serve as a standardized evaluation tool allowing early and accurate stroke diagnosis and severity stratification. ..
  35. SUBMACULAR SURGERY TRIALS PATHOLOGY CENTER
    Hans Grossniklaus; Fiscal Year: 2003
    ..Additionally, eyes obtained post-mortem from patients enrolled in the SST will be studied for pathologic correlation with clinical findings and outcomes. ..
  36. Control of Eye Melanoma Metastasis
    Hans Grossniklaus; Fiscal Year: 2003
    ..Both the IFN and angiostatin will prevent the progression of micrometastases into metastases by anti-angiogenesis. Angiostatin will prevent metastases by an anti-melanoma invasion effect. ..
  37. HUMAN TYROSINE HYDROXYLASE AND SCHIZOPHRENIA
    John Haycock; Fiscal Year: 2003
    ..age-matched, sudden-death control subjects having no Axis 1 mental disorder. Parallel, collaborative studies of major depressives will provide comparison groups and allow identification of potential disease-specific differences. ..
  38. Exacerbation of Alzheimer's Disease by Nitrous Oxide
    W Kofke; Fiscal Year: 2003
    ..Moreover, observation of a protective effect may result in discovery of an easily implemented preventative drug therapy for AD. ..
  39. MULTIFOCAL NEURODEGENERATION IN ALZHEIMER'S DISEASE
    Brent Vogt; Fiscal Year: 2002
    ....
  40. PHARMACOLOGY--ALLOSTERIC MODULATORS OF GABAA RECEPTORS
    Alessandro Guidotti; Fiscal Year: 2002
    ....
  41. The involvement of LIM kinase in metastases
    Ora Bernard; Fiscal Year: 2004
    ..These experiments will allow us to establish the role of LIMK1 in metastases with the ultimate goal of using it for diagnosis of metastatic cancer and for developing compounds that inhibit the activity of this kinase. ..
  42. Stress and Sex Effects on Learning and Dendritic Spines
    Benedetta Leuner; Fiscal Year: 2004
    ..Thus, the goal of my proposal is to determine whether glucocorticoids in males and estrogen in females contribute to the sexually opposed stress on dendritic spine density. ..
  43. ROS Defense Mechanisms in Brain Reoxygenation
    Sarah Milton; Fiscal Year: 2004
    ....
  44. Demyelination Plus Transplantation to Study CNS Repair
    Hans Keirstead; Fiscal Year: 2006
    ..abstract_text> ..
  45. REELIN DEFICIENCY--MODEL FOR SCHIZOPHRENIA VULNERABILITY
    Alessandro Guidotti; Fiscal Year: 2004
    ....
  46. Novel Intervention for Amyloid-Induced Neuroinflammation
    MICHAEL VITEK; Fiscal Year: 2007
    ..If COG133 can reduce the brain inflammation, it may also improve the behavioral performance of these animals. Pu [unreadable] [unreadable] [unreadable]..
  47. IMPROVED ASSAYS FOR SPECIFICALLY MEASURING COLLAGENASE-3
    MICHAEL VITEK; Fiscal Year: 2004
    ..This "assay" kit can then be used in arthritis and cancer by assessing disease progression. ..
  48. TREATMENT OF TRAUMATIC BRAIN INJURY WITH SIMVASTATIN
    Asim Mahmood; Fiscal Year: 2009
    ..abstract_text> ..
  49. CELLULAR REGULATION OF TYROSINE HYDROXYLASE
    John Haycock; Fiscal Year: 2001
    ..The effects of haloperidol on Ser19, Ser3l, and Ser4O phosphorylation will be studied by immunohistochemical and blot immunolabeling procedures using site- and phosphorylation state-specific antibodies. ..
  50. OEC 9800 C-ARM - DIGITAL MOBILE IMAGING SYSTEM
    E Connolly; Fiscal Year: 2003
    ..In summary, high quality fluoroscopy, as provided by the OEC 9800 Digital Mobile Imaging System, is the most important means by which we can continue to refine the primate stroke model. ..
  51. MECHANISMS OF MEMORY DEFICITS FOLLOWING BRAIN INJURY
    Pramod Dash; Fiscal Year: 2006
    ..Furthermore, this project will broaden our understanding of the pathogenesis of neurodegenerative diseases such as stroke and Alzheimer's disease. ..
  52. LONG TERM HIPPOCAMPAL MEMORY
    Pramod Dash; Fiscal Year: 2001
    ..Understanding the molecular basis of memory storage will be of value in the future development of pharmacological agents to treat amnesia associated with neurological disorders and other mental health related problems. ..
  53. NITRIC OXIDE, PLP ACYLATION & THE PATHOPHYSIOLOGY OF MS
    OSCAR BIZZOZERO; Fiscal Year: 2003
    ..abstract_text> ..
  54. Working memory deficits following brain trauma
    Pramod Dash; Fiscal Year: 2009
    ..An understanding of the mechanisms by which TBI alters dopamine signaling is critical for the development of mechanism-based intelligent pharmacological treatments for working memory deficits for brain trauma patients. ..
  55. MECHANISMS OF NO-MEDIATED PROTEIN S-NITROSYLATION IN EAE
    OSCAR BIZZOZERO; Fiscal Year: 2007
    ..abstract_text> ..
  56. Prefrontal cortex and memory storage
    Pramod K Dash; Fiscal Year: 2010
    ....
  57. Reward comparison, drugs of abuse & the gustatory cortex
    RASTAFA GEDDES; Fiscal Year: 2004
    ..Finally, Specific Aim III will determine whether an intact gustatory cortex is essential for retention of a preoperatively acquired association between the saccharin CS and the drug. ..
  58. Combination Therapy for Chronic Stroke-Induced Impairment
    J Leigh Leasure; Fiscal Year: 2008
    ..The proposed experiment will test a potential treatment for chronic stroke-related impairment in the aged brain. [unreadable] [unreadable] [unreadable]..
  59. ADENOSINE AND TRAUMATIC BRAIN INJURY
    Patrick Kochanek; Fiscal Year: 2007
    ..These studies explore the most promising adenosine-based therapy for TBI-A2a receptor antagonists. Our bench to bedside track record ensures translation to the clinic. [unreadable] [unreadable]..
  60. REPRESENTATION OF SATIETY IN ORBITOFRONTAL CORTEX
    THOMAS PRITCHARD; Fiscal Year: 2003
    ..These data may expedite development of successful strategies for diagnosis and treatment of various eating and metabolic disorders. ..
  61. FUNCTION AND ASSEMBLY OF CO2 ASSIMILATORY ENZYMES
    F Tabita; Fiscal Year: 2005
    ..Of particular interest will be the relationship of protein folding and catalysis to cellular function. ..
  62. MOLECULAR BASIS AND ENZYMOLOGY OF MICROBIAL BIOSYNTHESIS
    F Tabita; Fiscal Year: 2003
    ..For each enzyme, recombinant systems will be used to facilitate efforts to learn how these proteins function specifically in biosynthesis and how control of their activity influences normal cellular metabolism. ..
  63. Functional Aspects of Adult Hippocampal Neurogenesis
    JULIAN KEITH; Fiscal Year: 2007
    ..abstract_text> ..