Genomes and Genes
Summary: An enzyme of the lyase class that catalyzes the dehydration of 2-phosphoglycerate to form phosphoenolpyruvate. (Dorland, 28th ed) EC 220.127.116.11.
Publications265 found, 100 shown here
- Genes of glycolysis are ubiquitously overexpressed in 24 cancer classesB Altenberg
Bioinformatics Group, European Molecular Biology Laboratory, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
Genomics 84:1014-20. 2004..This classification may be useful when cancer therapies aimed at the Warburg effect are designed...
- Autoimmunity to specific citrullinated proteins gives the first clues to the etiology of rheumatoid arthritisNatalia Wegner
The Kennedy Institute of Rheumatology, Imperial College London, London, UK
Immunol Rev 233:34-54. 2010..Thus, both smoking and Porphyromonas gingivalis are attractive etiological agents for further investigation into the gene/environment/autoimmunity triad of RA...
- Adult rat and human bone marrow stromal cells differentiate into neuronsD Woodbury
Department of Neuroscience and Cell Biology, UMDNJ Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
J Neurosci Res 61:364-70. 2000..Consequently, adult marrow stromal cells can be induced to overcome their mesenchymal commitment and may constitute an abundant and accessible cellular reservoir for the treatment of a variety of neurologic diseases...
- Enolase-1 promotes plasminogen-mediated recruitment of monocytes to the acutely inflamed lungMalgorzata Wygrecka
Department of Biochemistry, Faculty of Medicine, University of Giessen Lung Center, Giessen, Germany
Blood 113:5588-98. 2009..These data suggest an important mechanism of inflammatory cell invasion mediated by increased cell-surface expression of ENO-1...
- Enolase in the RNA degradosome plays a crucial role in the rapid decay of glucose transporter mRNA in the response to phosphosugar stress in Escherichia coliTeppei Morita
Division of Biological Science, Graduate School of Science, Nagoya University, Chikusa, Nagoya 464 8602, Japan
Mol Microbiol 54:1063-75. 2004..In addition, we show that PNPase and RhlB within the degradosome cooperate to eliminate short degradation intermediates of ptsG mRNA...
- LOS2, a genetic locus required for cold-responsive gene transcription encodes a bi-functional enolaseHojoung Lee
Department of Plant Sciences, University of Arizona, Tucson, AZ 85721, USA
EMBO J 21:2692-702. 2002..Our results demonstrate that cold-responsive gene transcription in plants is controlled by a bi-functional enolase...
- α-Enolase: a promising therapeutic and diagnostic tumor targetMichela Capello
Department of Medicine and Experimental Oncology, Center for Experimental Research and Medical Studies CERMS, San Giovanni Battista Hospital, University of Turin, Turin, Italy
FEBS J 278:1064-74. 2011..In our opinion, this information can pave the way for effective new therapeutic and diagnostic strategies to counteract the growth of the most aggressive human disease...
- Antibodies to citrullinated alpha-enolase peptide 1 are specific for rheumatoid arthritis and cross-react with bacterial enolaseKarin Lundberg
Kennedy Institute of Rheumatology, Imperial College London, London, UK
Arthritis Rheum 58:3009-19. 2008..To map the antibody response to human citrullinated alpha-enolase, a candidate autoantigen in rheumatoid arthritis (RA), and to examine cross-reactivity with bacterial enolase...
- Mass spectrometry analysis of the post-translational modifications of alpha-enolase from pancreatic ductal adenocarcinoma cellsWeidong Zhou
Center for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, Virginia 20110, USA
J Proteome Res 9:2929-36. 2010..The result showed that more acetylated lysines, methylated aspartic acids, and glutamic acids were found in PDAC cells than that of normal pancreatic duct cells...
- Interactions of enolase isoforms with tubulin and microtubules during myogenesisA Keller
Laboratoire CRRET, CNRS UMR 7149, Universite Paris 12, 94010 Creteil, France
Biochim Biophys Acta 1770:919-26. 2007..We suggest that the binding of enolase to microtubules could contribute to the regulation of the dynamism of the cytoskeletal filaments known to occur during the transition from myoblast to myotubes...
- Isolation and characterization of alpha-enolase, a novel fibronectin-binding protein from Streptococcus suisMiriam Esgleas
Groupe de Recherche sur les Maladies Infectieuses du Porc GREMIP and Centre de Recherche en Infectiologie Porcine CRIP, Faculte de Medecine Veterinaire, Universite de Montreal, Quebec, Canada
Microbiology 154:2668-79. 2008..suis...
- ENO1, a potential prognostic head and neck cancer marker, promotes transformation partly via chemokine CCL20 inductionSen Tien Tsai
Department of Otolaryngology, National Cheng Kung University Hospital, Tainan 70428, Taiwan, ROC
Eur J Cancer 46:1712-23. 2010..Together, we demonstrate a prognostic role of ENO1 overexpression in head and neck cancer and ENO1-mediated promotion of cell transformation and invasion partly via induced CCL20 expression...
- An integrated humoral and cellular response is elicited in pancreatic cancer by alpha-enolase, a novel pancreatic ductal adenocarcinoma-associated antigenPaola Cappello
Center for Experimental Research and Medical Studies, San Giovanni Battista Hospital, Torino, Italy
Int J Cancer 125:639-48. 2009..It is thus a promising and clinically relevant molecular target candidate for immunotherapeutic approaches as new adjuvants to conventional treatments in pancreatic cancer...
- Glial and neuronal proteins in serum predict outcome after severe traumatic brain injuryP E Vos
Department of Neurology, University Medical Centre Nijmegen, The Netherlands
Neurology 62:1303-10. 2004..To study the ability of glial (glial fibrillary acidic protein [GFAP] and S100b) and neuronal (neuron specific enolase [NSE]) protein levels in peripheral blood to predict outcome after severe traumatic brain injury...
- Proteomics-based identification of alpha-enolase as a tumor antigen in non-small lung cancerPing He
Department of Molecular Medicine, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
Cancer Sci 98:1234-40. 2007..Therefore, autoantibodies against alpha-enolase may constitute a promising biomarker for NSCLC...
- Quantitative proteomics of the tonoplast reveals a role for glycolytic enzymes in salt toleranceBronwyn J Barkla
Instituto de Biotecnologia, Universidad Nacional Autonoma de Mexico, Colonia Miraval, Cuernavaca, Morelos, Mexico
Plant Cell 21:4044-58. 2009..The association of glycolytic proteins with the tonoplast may not only channel ATP to the V-ATPase, but also directly upregulate H(+)-pump activity...
- Identification of alpha-enolase as an autoantigen in lung cancer: its overexpression is associated with clinical outcomesGee Chen Chang
Division of Chest Medicine, Department of Internal Medicine, Taichung Veterans General Hospital, Taipei, Taiwan, Republic of China
Clin Cancer Res 12:5746-54. 2006..In this study, we intended to identify more TAAs in pleural effusion-derived tumor cells...
- Inhibition of cell surface mediated plasminogen activation by a monoclonal antibody against alpha-EnolaseRoser Lopez-Alemany
Centre d Oncologia Molecular C O M, Institut de Recerca Oncolgica IRO, Barcelona, Spain
Am J Hematol 72:234-42. 2003..These data suggest that, although leukocytic cells display several molecules that bind plasminogen, alpha-enolase is responsible for the majority of the promotion of plasminogen activation on the surfaces of leukocytic cells...
- Identification and validation of metastasis-associated proteins in head and neck cancer cell lines by two-dimensional electrophoresis and mass spectrometryWeiguo Wu
Department of Thoracic Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
Clin Exp Metastasis 19:319-26. 2002..The results also suggest an important complementary role for proteomics in identification of molecular abnormalities important in cancer development and progression...
- Circulating autoantibodies to phosphorylated α-enolase are a hallmark of pancreatic cancerBarbara Tomaino
Center for Experimental Research and Medical Studies CERMS, San Giovanni Battista Hospital, Turin, Italy
J Proteome Res 10:105-12. 2011..In conclusion, our results demonstrate that ENOA phosphorylation is associated with PDAC and induces specific autoantibody production in PDAC patients that may have diagnostic value...
- Extracellular proteins of Lactobacillus crispatus enhance activation of human plasminogenVeera Hurmalainen
General Microbiology, Faculty of Biosciences, PO Box 56, FIN00014 University of Helsinki, Finland
Microbiology 153:1112-22. 2007..So far, interference with the Plg system has been addressed with pathogenic microbes. The results reported here demonstrate a novel interaction between a member of the microbiota and a major proteolytic system in humans...
- Proteomic identification of oxidatively modified proteins in Alzheimer's disease brain. Part II: dihydropyrimidinase-related protein 2, alpha-enolase and heat shock cognate 71Alessandra Castegna
Department of Chemistry, Center of Membrane Sciences, University of Kentucky, Lexington, Kentucky 40506, USA
J Neurochem 82:1524-32. 2002..These results are discussed with reference to potential involvement of these oxidatively modified proteins in neurodegeneration in AD brain...
- Binding of Candida albicans enolase to plasmin(ogen) results in enhanced invasion of human brain microvascular endothelial cellsAmbrose Y Jong
Division of Hematology Oncology, Mailstop 57, Childrens Hospital Los Angeles, Los Angeles, CA 90027, USA
J Med Microbiol 52:615-22. 2003..The results given here indicate that Candida enolase is a plasminogen- and plasmin-binding protein and that the interaction of C. albicans enolase with the plasminogen system may contribute to invasion of the tissue barrier...
- Glial loss in the prefrontal cortex is sufficient to induce depressive-like behaviorsMounira Banasr
Laboratory of Molecular Psychiatry, Center for Genes and Behavior, Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06508, USA
Biol Psychiatry 64:863-70. 2008..However, it is unclear whether this glial loss plays a direct role in the expression of depressive symptoms...
- Decoding serological response to Candida cell wall immunome into novel diagnostic, prognostic, and therapeutic candidates for systemic candidiasis by proteomic and bioinformatic analysesAida Pitarch
Department of Microbiology II, Faculty of Pharmacy, Complutense University of Madrid, 28040 Madrid, Spain
Mol Cell Proteomics 5:79-96. 2006..Furthermore serum anti-wall enolase antibodies are a new prognostic indicator for SC and confer protection against it. Bgl2p and wall-associated enolase could be valuable candidates for future vaccine development...
- Neuronal activation of NF-kappaB contributes to cell death in cerebral ischemiaWen Zhang
Department of Neurology, University of Heidelberg, Heidelberg, Germany
J Cereb Blood Flow Metab 25:30-40. 2005..In summary, the data show that NF-kappaB is activated in neurons and astrocytes during cerebral ischemia and that NF-kappaB activation in neurons contributes to the ischemic damage...
- Serum markers support disease-specific glial pathology in major depressionMatthias L Schroeter
Queen Elisabeth Hospital, Department of Psychiatry, 10362 Berlin, Germany
J Affect Disord 111:271-80. 2008..Recently, it was shown by histopathological studies that mood disorders are characterized by disease-specific glial pathology...
- Alpha-enolase: a target of antibodies in infectious and autoimmune diseasesBenjamin Terrier
Paris Descartes University, Faculty of Medicine, UPRES EA 4058, Paris, France
Autoimmun Rev 6:176-82. 2007..However, further studies are needed to improve our knowledge on the pathogenic role of these Abs...
- Glioma cell populations grouped by different cell type markers drive brain tumor growthLars Prestegarden
Oncomatrix Research Lab, Department of Biomedicine and Norlux Neuro Oncology, Department of Biomedicine, University of Bergen, Bergen, Norway
Cancer Res 70:4274-9. 2010..These findings suggest that the ability to form tumors may be a general trait associated with different glioma cell phenotypes, rather than a property limited to an exclusive subpopulation of glioma stem cells...
- Multiple antibody reactivities to citrullinated antigens in sera from patients with rheumatoid arthritis: association with HLA-DRB1 allelesO Snir
Department of Medicine, Rheumatology Unit, Karolinska University Hospital, Karolinska Institute, Solna, Stockholm, Sweden
Ann Rheum Dis 68:736-43. 2009..Autoantibodies to cyclic citrullinated peptides (anti-CCP) are present in most patients with rheumatoid arthritis (RA), and associate with HLA-DRB1 shared epitope (SE) alleles...
- Oxidative stress parameters in unmedicated and treated bipolar subjects during initial manic episode: a possible role for lithium antioxidant effectsRodrigo Machado-Vieira
Mood Disorders Program, HMIPV, Fundacao Faculdade Federal Ciencias Medicas de Porto Alegre and Bipolar Disorder Research Program, Espirita Hospital of Porto Alegre, Porto Alegre, Brazil
Neurosci Lett 421:33-6. 2007..Antioxidant effects using lithium in mania were shown, and further studies are necessary to evaluate the potential role of these effects in the pathophysiology and therapeutics of BD...
- Circulating antibodies against alpha-enolase in patients with primary membranous nephropathy (MN)H Wakui
Third Department of Internal Medicine, Akita University School of Medicine, Akita, Japan
Clin Exp Immunol 118:445-50. 1999....
- An increase in S-glutathionylated proteins in the Alzheimer's disease inferior parietal lobule, a proteomics approachShelley F Newman
Department of Chemistry, University of Kentucky, Lexington, Kentucky 40506, USA
J Neurosci Res 85:1506-14. 2007..This study demonstrates that specific proteins are sensitive to S-glutathionylation, which most likely is due to their sensitivity to cysteine oxidation initiated by the increase in oxidative stress in the AD brain...
- Identification of enolase as a laminin-binding protein on the surface of Staphylococcus aureusCelia R W Carneiro
Discipline of Immunology, Microbiology, Immunology and Parasitology Department, Federal University of Sao Paulo, Sao Paulo, Brazil
Microbes Infect 6:604-8. 2004..aureus alpha-enolase was further confirmed by flow cytometry. Hence, alpha-enolase might play a critical role in the pathogenesis of S. aureus by allowing its adherence to laminin-containing extracellular matrix...
- The nine residue plasminogen-binding motif of the pneumococcal enolase is the major cofactor of plasmin-mediated degradation of extracellular matrix, dissolution of fibrin and transmigrationSimone Bergmann
Research Center for Infectious Diseases, University of Wurzburg, Germany
Thromb Haemost 94:304-11. 2005....
- Presence of autoantibodies to the glycolytic enzyme alpha-enolase in sera from patients with early rheumatoid arthritisVincent Saulot
Institut National de la Sante et de la Recherche Medicale, Rouen, France
Arthritis Rheum 46:1196-201. 2002..To identify a new autoantigen/autoantibody population in rheumatoid arthritis (RA) sera...
- Increased cerebrospinal fluid and serum levels of S100B in first-onset schizophrenia are not related to a degenerative release of glial fibrillar acidic protein, myelin basic protein and neurone-specific enolase from glia or neuronesJ Steiner
Department of Psychiatry, University of Magdeburg, Leipziger Strasse 44, D 39120 Magdeburg, Germany
J Neurol Neurosurg Psychiatry 77:1284-7. 2006..To assess levels of glial fibrillar acidic protein (GFAP), myelin basic protein (MBP), neurone-specific enolase (NSE) and S100B in patients with first-onset schizophrenia...
- Immunogenic and plasminogen-binding surface-associated alpha-enolase of Trichomonas vaginalisV Mundodi
Department of Microbiology and Immunology, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
Infect Immun 76:523-31. 2008..These data indicate that as with other bacterial pathogens, tv-ENO1 is an anchorless, surface-associated glycolytic enzyme of T. vaginalis...
- alpha-enolase, a novel strong plasmin(ogen) binding protein on the surface of pathogenic streptococciV Pancholi
Laboratory of Bacterial Pathogenesis and Immunology, The Rockefeller University, New York, New York 10021, USA
J Biol Chem 273:14503-15. 1998..Our findings, showing both the protected protease activity of SEN-bound plasmin and SEN-specific immune responses, provide evidence for an important role of SEN in the disease process and post-streptococcal autoimmune diseases...
- Generation and characterization of anti-alpha-enolase single-chain antibodies in chickenSy Jye Leu
Department of Microbiology and Immunology, School of Medicine, Taipei Medical University, Taipei 110, Taiwan
Vet Immunol Immunopathol 137:251-60. 2010..All together, it is believed that these polyclonal and scFv IgY antibodies may be helpful in the development of molecular diagnostic and therapeutic agents for lung cancers in the future...
- Serum levels of S100B and NSE proteins in Alzheimer's disease patientsMarcia L Chaves
Servico de Neurologia, Hospital de Clinicas de Porto Alegre, Rua Ramiro Barcelos 2350, 90035 003 Porto Alegre, RS, Brazil
J Neuroinflammation 7:6. 2010..Alzheimer's disease is the most common dementia in the elderly, and the potential of peripheral biochemical markers as complementary tools in the neuropsychiatric evaluation of these patients has claimed further attention...
- Antibodies to several citrullinated antigens are enriched in the joints of rheumatoid arthritis patientsOmri Snir
Karolinska University Hospital, Karolinska Institutet at Solna, Stockholm, Sweden
Arthritis Rheum 62:44-52. 2010..Furthermore, we studied their relationships with mutated citrullinated vimentin (MCV), a newly identified RA-specific serum assay, and the classic cyclic citrullinated peptide (CCP) in the synovial fluid of well-defined HLA-DR groups...
- A new nuclear function of the Entamoeba histolytica glycolytic enzyme enolase: the metabolic regulation of cytosine-5 methyltransferase 2 (Dnmt2) activityAyala Tovy
Department of Molecular Microbiology, The Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel
PLoS Pathog 6:e1000775. 2010..histolytica expressing a nuclear localization signal (NLS)-fused-enolase. These results establish enolase as the first Dnmt2 interacting protein, and highlight an unexpected role of a glycolytic enzyme in the modulation of Dnmt2 activity...
- Paracoccidioides brasiliensis enolase is a surface protein that binds plasminogen and mediates interaction of yeast forms with host cellsSarah Veloso Nogueira
Laboratorio de Biologia Molecular, Instituto de Ciencias Biologicas, ICBII, Campus II, Universidade Federal de Goias, 74001 970, Goiania, Goias, Brazil
Infect Immun 78:4040-50. 2010..The expression of PbEno was upregulated in yeast cells derived from mouse-infected tissues. These data indicate that surface-associated PbEno may contribute to the pathogenesis of P. brasiliensis...
- Direct characterization of target podocyte antigens and auto-antibodies in human membranous glomerulonephritis: Alfa-enolase and borderline antigensMaurizio Bruschi
Division of Nephrology and Laboratory on Pathophysiology of Uremia, G Gaslini Children Hospital, Genoa, Italy
J Proteomics 74:2008-17. 2011..Circulating anti α-enolase auto-antibodies can be detected in sera of a significant quota of MGN patients. Like other auto-antigens, α-enolase may be implicated in the pathogenesis of human MGN...
- α-Enolase expressed on the surfaces of monocytes and macrophages induces robust synovial inflammation in rheumatoid arthritisSeyeon Bae
Department of Anatomy, Seoul National University College of Medicine, Seoul 110 799, Republic of Korea
J Immunol 189:365-72. 2012....
- Plasmodium ookinetes coopt mammalian plasminogen to invade the mosquito midgutAnil K Ghosh
Department of Molecular Microbiology and Immunology, Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
Proc Natl Acad Sci U S A 108:17153-8. 2011....
- Antibodies to citrullinated α-enolase peptide 1 and clinical and radiological outcomes in rheumatoid arthritisBenjamin A Fisher
Kennedy Institute of Rheumatology, Imperial College London, UK
Ann Rheum Dis 70:1095-8. 2011..The anti-CEP-1 positive subset is strongly associated with the HLA-DRB1 shared epitope and its interaction with smoking...
- Anti-alpha-enolase antibodies in patients with inflammatory Bowel diseaseNathalie Vermeulen
Department of Internal Medicine, University Hospital Leuven, Leuven, Belgium
Clin Chem 54:534-41. 2008..alpha-Enolase has been proposed as a target antigen in IBD. We evaluated the prevalence and diagnostic value of anti-alpha-enolase antibodies in IBD and related disorders...
- Proteomics characterization of gastrokine 1-induced growth inhibition of gastric cancer cellsGuang Rong Yan
Institute of Life and Health Engineering and National Engineering and Research Center for Genetic Medicine, Jinan University, Guangzhou, P R China
Proteomics 11:3657-64. 2011..These observations suggested that ENO1 downregulation played an important role in GKN1-induced growth inhibition of gastric cancer cells...
- Oxidative and nitrative modifications of alpha-enolase in cardiac proteins from diabetic ratsNaihao Lu
Department of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan, People s Republic of China
Free Radic Biol Med 48:873-81. 2010..Meanwhile, the up-regulation of alpha-enolase expression could be a protective mechanism to neutralize oxidative and nitrative stress in diabetes...
- Lateral transfer at the gene and subgenic levels in the evolution of eukaryotic enolaseP J Keeling
Department of Biology, Indiana University, Bloomington, IN 47405, USA
Proc Natl Acad Sci U S A 98:10745-50. 2001....
- Enhanced activation of bound plasminogen on Staphylococcus aureus by staphylokinaseTomi Mölkänen
Department of Bacteriology and Immunology, The Haartman Institute, FIN 00014 University of Helsinki, Helsinki, Finland
FEBS Lett 517:72-8. 2002....
- Enolase isoenzymes. III. Chromatographic and immunological characteristics of rat brain enolaseL Fletcher
Biochim Biophys Acta 452:245-52. 1976..5. It is therefore concluded that there are three genetic loci alpha, beta and gamma, coding for the enolase isoenzymes of rat tissues...
- Erythropoietin promotes neurovascular remodeling and long-term functional recovery in rats following traumatic brain injuryRuizhuo Ning
Department of Neurosurgery, Henry Ford Health System, Detroit, MI 48202, USA
Brain Res 1384:140-50. 2011..In conclusion, the beneficial effects of posttraumatic EPO treatment on injured brain persisted for at least 3 months. The long-term improvement in functional outcome may in part be related to the neurovascular remodeling induced by EPO...
- Differential modulation of alpha, beta and gamma enolase isoforms in regenerating mouse skeletal muscleT Merkulova
CNRS UPR 9065, College de France, Paris, France
Eur J Biochem 267:3735-43. 2000..Double labeling experiments with anti-gamma enolase and FITC-alpha bungarotoxin allowed us to follow the neuromuscular junction remodeling that occurs during muscle regeneration despite the absence of nerve injury...
- Multifunctional roles of enolase in Alzheimer's disease brain: beyond altered glucose metabolismD Allan Butterfield
Department of Chemistry, University of Kentucky, Lexington, Kentucky 40506 0055, USA
J Neurochem 111:915-33. 2009..This review examines potential altered function(s) of brain enolase in MCI, early-onset AD, and AD, alterations that may contribute to the biochemical, pathological, clinical characteristics, and progression of this dementing disorder...
- Elevated serum neuron-specific enolase in patients with temporal lobe epilepsy: a video-EEG studyJohanna Palmio
Department of Neurology, University of Tampere, FIN 33014 Tampere, Finland
Epilepsy Res 81:155-60. 2008..4). The levels of markers of neuronal damage were increased in patients with TLE, not only after tonic-clonic but also after complex partial seizures. These data suggest that TLE may be associated with brain damage...
- Synovial fluid is a site of citrullination of autoantigens in inflammatory arthritisAndrew Kinloch
Imperial College London, London, UK
Arthritis Rheum 58:2287-95. 2008..To examine synovial fluid as a site for generating citrullinated antigens, including the candidate autoantigen citrullinated alpha-enolase, in rheumatoid arthritis (RA)...
- Normal CSF neuron-specific enolase and S-100 protein levels in patients with recent non-complicated tonic-clonic seizuresJ Palmio
Department of Neurology, Tampere University Hospital, P O Box 2000, FIN 33521, Tampere, Finland
J Neurol Sci 183:27-31. 2001..Because larger studies addressing cerebrospinal fluid (CSF) levels of NSE or S-100 have not been performed, we measured CSF NSE and S-100 after tonic-clonic seizures to search for evidence of neuronal and glial damage...
- Glycolysis and rheumatoid arthritisXiaotian Chang
Key Laboratory for Bio Drugs of Ministry of Health, Provincial Laboratory for Bio Drugs of Ministry of Health, Research Center for Medicinal Biotechnology, Shandong Academy of Medical Sciences, Jinan, Shandong, China
Int J Rheum Dis 14:217-22. 2011..Lactate and pyruvate, substrates of RA synovium metabolism, stimulate abnormal cell proliferation, angiogenesis and pannus formation...
- Cisternal S100 protein and neuron-specific enolase are elevated and site-specific markers in intractable temporal lobe epilepsyB J Steinhoff
Department of Clinical Neurophysiology, Zentrum Neurologische Medizin, Georg August Universitat, Gottingen, Germany
Epilepsy Res 36:75-82. 1999..We conclude that interictal temporal lobe dysfunction corresponds with neuronal and glial marker elevations in the extracellular space and that site-specific elevations may predict the site of seizure origin biochemically...
- Validating serum S100B and neuron-specific enolase as biomarkers for the human brain - a combined serum, gene expression and MRI studyDaniel Paolo Streitbürger
Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany
PLoS ONE 7:e43284. 2012..Neuron-specific enolase (NSE) is a specific serum marker for neuronal damage. However, the specificity of these biomarkers for cell type and brain region has not been investigated in vivo until now...
- Plasmin(ogen)-binding alpha-enolase from Streptococcus pneumoniae: crystal structure and evaluation of plasmin(ogen)-binding sitesStefanie Ehinger
Division of Structural Biology, GBF German Research Center for Biotechnology, Mascheroder Weg 1, 38124 Braunschweig, Germany
J Mol Biol 343:997-1005. 2004..The nine residue plasminogen-binding motif, by contrast, is exposed on the octamer surface revealing this as the primary site of interaction between alpha-enolase and plasminogen...
- Plasminogen-mediated group A streptococcal adherence to and pericellular invasion of human pharyngeal cellsVijay Pancholi
Laboratory of Bacterial Pathogenesis, Public Health Research Institute, The International Center for Public Health, 225 Warren Street, W450T, Newark, NJ 07103 3535, USA
Microb Pathog 35:293-303. 2003....
- alpha-Enolase of Streptococcus pneumoniae is a plasmin(ogen)-binding protein displayed on the bacterial cell surfaceS Bergmann
Department of Microbial Pathogenicity, GBF German Research Centre for Biotechnology, Mascheroder Weg 1, D 38124 Braunschweig, Germany
Mol Microbiol 40:1273-87. 2001..The reassociation was also confirmed by immunoelectron microscopy. The results suggest a mechanism of plasminogen activation for human pathogens that might contribute to their virulence potential in invasive infectious processes...
- Plasminogen binding by oral streptococci from dental plaque and inflammatory lesionsBertil Kinnby
Department of Oral Biology, Malmo University, S 20506 Malmö, Sweden
Microbiology 154:924-31. 2008..The findings illustrate how apparently innocuous commensal bacteria are capable of utilizing a mechanism that is generally regarded as being of importance to pathogenicity and suggest an additional role of plasminogen binding...
- Evidence for nuclear localisation of two stage-specific isoenzymes of enolase in Toxoplasma gondii correlates with active parasite replicationDavid J P Ferguson
Nuffield Department of Pathology, John Radcliffe Hospital, University of Oxford, OX3 9DU, Oxford
Int J Parasitol 32:1399-410. 2002....
- Repeated restraint stress suppresses neurogenesis and induces biphasic PSA-NCAM expression in the adult rat dentate gyrusKara Pham
Laboratory of Neuroendocrinology, Rockefeller University, New York, New York 10021, USA
Eur J Neurosci 17:879-86. 2003..These studies may help us understand the basis for hippocampal shrinkage and raise questions about the ultimate reversibility of the effects of chronic stress...
- Tumor markers in neuroendocrine tumorsB Eriksson
Section for Endocrine Oncology, Department of Medical Sciences, University Hospital, Uppsala, Sweden
Digestion 62:33-8. 2000..Chromogranin A serum or plasma levels reflect tumor load, and it may be an independent marker of prognosis in patients with midgut carcinoids...
- Predictive power of serum NSE and OHCA score regarding 6-month neurologic outcome after out-of-hospital ventricular fibrillation and therapeutic hypothermiaTuomas Oksanen
Department of Anaesthesiology and Intensive Care Medicine, Helsinki University Hospital, Finland
Resuscitation 80:165-70. 2009....
- Enolase takes part in a macromolecular complex associated to mitochondria in yeastIrina Brandina
UMR 7156 Génétique Moléculaire, Génomique et Microbiologie CNRS, Université Louis Pasteur Strasbourg I Institut de Physiologie et Chimie Biologique, 21 rue René Descartes, 67084 Strasbourg, France
Biochim Biophys Acta 1757:1217-28. 2006..This suggests an unsuspected novel function for this complex in tRNA mitochondrial import...
- Structure of the human gene for alpha-enolaseA Giallongo
Istituto di Biologia dello Sviluppo del Consiglio Nazionale delle Ricerche, Palermo, Italy
Eur J Biochem 190:567-73. 1990..Furthermore, various sequences similar to known regulatory elements were detected...
- Turning blood into brain: cells bearing neuronal antigens generated in vivo from bone marrowE Mezey
Basic Neuroscience Program, Laboratory of Developmental Neurogenetics, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
Science 290:1779-82. 2000..These findings raise the possibility that bone marrow-derived cells may provide an alternative source of neurons in patients with neurodegenerative diseases or central nervous system injury...
- Prediction of short-term and long-term outcomes after cardiac arrest: a prospective multivariate approach combining biochemical, clinical, electrophysiological, and neuropsychological investigationsJörn Prohl
Department of Biological Psychology and Neuropsychology, University of Hamburg, Germany
Crit Care Med 35:1230-7. 2007..To determine the prognostic accuracy of biochemical, clinical, electrophysiological, and neuropsychological investigations in predicting outcomes after cardiac arrest...
- Serum biomarker concentrations and outcome after pediatric traumatic brain injuryRachel Pardes Berger
Department of Pediatrics, Division of Child Advocacy, Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Safar Center for Resuscitation Research, Pittsburgh, Pennsylvania 15213, USA
J Neurotrauma 24:1793-801. 2007..Future studies should focus on assessing the differential benefit of biomarkers compared with clinical variables and in assessing a continuous rather than categorical outcome variable...
- S100B and NSE serum levels in patients with Parkinson's diseaseDébora V Schaf
Departamento de Bioquimica, ICBS, UFRGS, Ramiro Barcelos 2600 anexo, 90035 003 Porto Alegre, RS, Brazil
Parkinsonism Relat Disord 11:39-43. 2005..006). Therefore, S100B and NSE may not have a diagnostic role in PD, but S100B may have a potential role as a marker of disease progression. The study of S100B may also contribute to elucidate the controversial role of glial cells in PD...
- Neuron-specific apolipoprotein e4 proteolysis is associated with increased tau phosphorylation in brains of transgenic miceWalter J Brecht
Gladstone Institute of Neurological Disease, San Francisco, California 94141 9100, USA
J Neurosci 24:2527-34. 2004..Neuron-specific proteolytic cleavage of apoE4 is associated with increased phosphorylation of tau and may play a key role in the development of AD-related neuronal deficits...
- The central nucleus of the amygdala and corticotropin-releasing factor: insights into contextual fear memoryMatthew W Pitts
Department of Cell and Molecular Biology, John A Burns School of Medicine, University of Hawaii, Honolulu, Hawaii 96813, USA
J Neurosci 29:7379-88. 2009..Collectively, our results suggest CeA involvement in the consolidation of contextual fear memory and specifically implicate CeA CRF as an important mediator...
- ENO1 gene product binds to the c-myc promoter and acts as a transcriptional repressor: relationship with Myc promoter-binding protein 1 (MBP-1)S Feo
Dipartimento di Biologia Cellulare e dello Sviluppo, Universita di Palermo, Viale delle Scienze, Parco d Orleans, 90128, Palermo, Italy
FEBS Lett 473:47-52. 2000....
- Anti-enolase-alpha autoantibodies in cancer-associated retinopathy: epitope mapping and cytotoxicity on retinal cellsG Adamus
Neurological Sciences Institute, Oregon Health Sciences University, 1120 NW 20th Ave, Portland, OR, USA
J Autoimmun 11:671-7. 1998..These studies showed that anti-enolase antibodies from patients with CAR were able to induce apoptotic cell death in E1A.NR3 retinal cells and provided a potential mechanism for retinal degeneration in humans...
- In vitro differentiation of human marrow stromal cells into early progenitors of neural cells by conditions that increase intracellular cyclic AMPW Deng
Center for Gene Therapy, Tulane University Health Sciences Center, SL-99, 1430 Tulane Avenue, New Orleans, Louisiana, 70112, USA
Biochem Biophys Res Commun 282:148-52. 2001..The data suggested that the hMSCs may have been differentiated into early progenitors of neural cells in vitro under conditions that increase the intracellular level of cAMP...
- Cathepsin X cleaves the C-terminal dipeptide of alpha- and gamma-enolase and impairs survival and neuritogenesis of neuronal cellsNatasa Obermajer
University of Ljubljana, Faculty of Pharmacy, Ljubljana, Slovenia
Int J Biochem Cell Biol 41:1685-96. 2009..On the other hand, the proliferation of cells is decreased, indicating induction of differentiation. Our study reveals enolase isozymes as crucial neurotrophic factors that are regulated by the proteolytic activity of cathepsin X...
- Oxidative stress-induced proteome alterations target different cellular pathways in human myoblastsMartin A Baraibar
Laboratoire de Biologie Cellulaire du Vieillissement, UR4, Universite Pierre et Marie Curie Paris 6, 75252 Paris Cedex 05, France
Free Radic Biol Med 51:1522-32. 2011..This study emphasizes the importance of performing analysis addressing different aspects of the cellular proteome to have a more accurate view of their changes upon stress...
- Multifunctional alpha-enolase: its role in diseasesV Pancholi
Laboratory of Bacterial Pathogenesis and Immunology, The Rockefeller University, New York, NewYork 10021, USA
Cell Mol Life Sci 58:902-20. 2001..In addition to this property, its ability to function as a heat-shock protein and to bind cytoskeletal and chromatin structures indicate that enolase may play a crucial role in transcription and a variety of pathophysiological processes...
- Non-neuronal enolase is an endothelial hypoxic stress proteinR M Aaronson
Pulmonary Center, Boston University School of Medicine, Massachusetts 02118, USA
J Biol Chem 270:27752-7. 1995..4-fold. While hypoxic up-regulation of NNE may have a protective effect by augmenting anaerobic metabolism, we speculate that enolase may contribute to EC hypoxia tolerance through one or more of its nonglycolytic functions...
- Retinoic acid-mediated down-regulation of ENO1/MBP-1 gene products caused decreased invasiveness of the follicular thyroid carcinoma cell linesBogusz Trojanowicz
AG Experimentelle and Chirurgische Onkologie, Universitätsklinik und Poliklinik für Allgemein, Viszeral und Gefässchirurgie, Martin Luther Universitat, Halle S, Germany
J Mol Endocrinol 42:249-60. 2009....
- Diagnostic detection of human lung cancer-associated antigen using a gold nanoparticle-based electrochemical immunosensorJa An Annie Ho
Bioanalytical Laboratory, Department of Chemistry, National Tsing Hua University, Hsinchu 300, Taiwan
Anal Chem 82:5944-50. 2010..This AuNP congregate-based assay provides an amplification approach for detecting ENO1 at trace levels, leading to a detection limit as low as 11.9 fg (equivalent to 5 microL of a 2.38 pg/mL solution)...
- Cloning and characterization of a plasminogen-binding surface-associated enolase from Schistosoma bovisEduardo de la Torre-Escudero
Parasitology Laboratory, Instituto de Recursos Naturales y Agrobiología de Salamanca IRNASA, CSIC, Cordel de Merinas, 40 52, 37008 Salamanca, Spain
Vet Parasitol 173:76-84. 2010....
- Neuron-specific enolase correlates with other prognostic markers after cardiac arrestT Cronberg
Division of Neurology, Department of Clinical Sciences, Skane University Hospital, Lund University, Lund, Sweden
Neurology 77:623-30. 2011..This prospective, observational study describes the pattern of commonly used prognostic markers in a hypothermia-treated cohort of cardiac arrest patients with prolonged coma...
- Targeted deletion of a yeast enolase structural gene. Identification and isolation of yeast enolase isozymesL McAlister
J Biol Chem 257:7181-8. 1982....
- Plasminogen/plasmin regulates alpha-enolase expression through the MEK/ERK pathwayLirlandia P Sousa
Grupo de Transdução de Sinal, Departamento de Microbiologia, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, 31270 901 Belo Horizonte, Minas Gerais, Brazil
Biochem Biophys Res Commun 337:1065-71. 2005..Altogether, our data show that Plg/Pla regulates alpha-ENO expression through the MEK/ERK pathway...
- pH-dependent association of enolase and glyceraldehyde-3-phosphate dehydrogenase of Lactobacillus crispatus with the cell wall and lipoteichoic acidsJenni Antikainen
General Microbiology, Faculty of Biosciences, P O Box 56, FIN 00014 University of Helsinki, Finland
J Bacteriol 189:4539-43. 2007..These proteins bound to lipoteichoic acids at a pH below their isoelectric point. The results indicate that lactobacilli rapidly modify their surface properties in response to changes in pH...
- Catalase and alpha-enolase: two novel granulocyte autoantigens in inflammatory bowel disease (IBD)C Roozendaal
Department of Clinical Immunology, University Hospital, Groningen, The Netherlands
Clin Exp Immunol 112:10-6. 1998..This study is the first to report catalase and alpha-enolase as granulocyte antigens for autoantibodies in IBD...
- Molecular evolution of enolaseMichał Piast
Department of Medical Biochemistry, Wrocław Medical University, Wrocław, Poland
Acta Biochim Pol 52:507-13. 2005..Tolerated substitutions occur most frequently in alpha-enolase, while the lowest number of substitutions has accumulated in gamma-enolase, which may suggest that it is the most recently evolved isoenzyme of enolase in vertebrates...
- S-100B is superior to NSE, BDNF and GFAP in predicting outcome of resuscitation from cardiac arrest with hypothermia treatmentErik Mörtberg
Department of Surgical Sciences, Anaesthesia and Intensive Care, Uppsala University, Uppsala University Hospital, Uppsala, Sweden
Resuscitation 82:26-31. 2011....
- Hypoxia induces differential translation of enolase/MBP-1Kara C Sedoris
James Graham Brown Cancer Center, Department of Medicine, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
BMC Cancer 10:157. 2010..We have previously shown that MBP-1 and its binding to the c-myc P2 promoter regulates the metabolic and cellular growth changes that occur in response to altered exogenous glucose concentrations...
- Can monomers of yeast enolase have enzymatic activity?M J Kornblatt
Department of Chemistry and Biochemistry, Concordia University, Montreal, Quebec, Canada
Eur J Biochem 251:775-80. 1998..The precise conformation of these, loops is necessary for binding Mg2+ (and, hence, for activity) and for maintaining subunit interactions...
- Neuron specific enolase and S-100B as predictors of outcome after cardiac arrest and induced hypothermiaMalin Rundgren
Department of Anaesthesia and Intensive Care, Lund University Hospital, Sweden
Resuscitation 80:784-9. 2009..To assess the prognostic value of repetitive serum samples of neuron specific enolase (NSE) and S-100B in cardiac arrest patients treated with hypothermia...
- SEDLIN forms homodimers: characterisation of SEDLIN mutations and their interactions with transcription factors MBP1, PITX1 and SF1Jeshmi Jeyabalan
Academic Endocrine Unit, Nuffield Department of Clinical Medicine, Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, United Kingdom
PLoS ONE 5:e10646. 2010..SEDLIN mutations cause X-linked spondyloepiphyseal dysplasia tarda (SEDT)...
- Cytokine-induced stable neuronal differentiation of human bone marrow mesenchymal stem cells in a serum/feeder cell-free conditionHelen Tao
Department of Haematology and Haemopoietic Stem Cell Transplantation, St Vincent s Hospital Sydney, New South Wales, Australia
Dev Growth Differ 47:423-33. 2005..Our results show that MSC isolated by two different procedures produced identical lineage differentiation with defined growth factors in a serum- and feeder cell-free condition...
- GENOMIC ENZYMOLOGY: THE CROTONASE SUPERFAMILYJOHN GERLT; Fiscal Year: 2003..5) 3-OH Isobutyryl CoA hydrolase (HIBCH) catalyzes hydrolysis of a thioester in valine catabolism. We will study HIBCH so that we can determine whether the reaction proceeds via and enolate anion or an anionic tetrahedral intermediate. ..
- GENOMIC ENZYMOLOGY: THE ENOLASE SUPERFAMILYJOHN GERLT; Fiscal Year: 2006..4) We will test a structural blueprint for functional diversity in the (beta/alpha)7beta-barrel fold by determining whether new functions can be generated by in vitro evolution. ..
- Aging as a risk factor for seizure-induced cell deathPAULA SCHAUWECKER; Fiscal Year: 2007..unreadable] [unreadable] [unreadable] [unreadable]..
- Genetic Regulation of Seizure-Induced NeurogenesisPAULA SCHAUWECKER; Fiscal Year: 2004..abstract_text> ..
- Signal Transduction Mechanisms in Suicide BrainYogesh Dwivedi; Fiscal Year: 2008..abstract_text> ..
- POSTRECEPTOR DYSREGULATION IN DEPRESSIONYogesh Dwivedi; Fiscal Year: 2004..abstract_text> ..
- Validating microRNA Analysis in Human Postmortem BrainYogesh Dwivedi; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Epileptogenicity in the Developing BrainRaman Sankar; Fiscal Year: 2007..Our findings will provide the basis for future neuroprotective interventions targeting the developing brain at different stages of status epilepticus in order to interrupt the course of the epileptogenic process. ..
- Synaptosomal Protein Changes After EtOH Self-AdministrationFrank Witzmann; Fiscal Year: 2006..unreadable] [unreadable]..
- Novel Immunological Modifer as a Tissue ProtectorMICHAEL VITEK; Fiscal Year: 2006..unreadable] [unreadable] [unreadable]..
- Androgens and apoE4 induced cognitive impairmentsJacob Raber; Fiscal Year: 2005....
- Mitochondrial Dysfunction in Pediatric Head InjuryCourtney Robertson; Fiscal Year: 2006..abstract_text> ..
- Interleukin-1 and Memory Loss in AgingCarmelina Gemma; Fiscal Year: 2006....
- BACKTRACKING TRANSLOCATIONS IN CHILDHOOD LEUKEMIAJoseph Wiemels; Fiscal Year: 2006..We are ultimately working to elucidate the origin and causes of a cancer that might be preventable. [unreadable] [unreadable]..
- NOVEL INHIBITORS OF BRAIN ISCHEMIAMICHAEL VITEK; Fiscal Year: 2003..In Phase I, we will measure the effect of treatment with synthetic KPI domain to reduce fibrin deposition and improve behavioral performance in a mouse model for focal ischemic injury. ..
- Novel Intervention for ColitisMICHAEL VITEK; Fiscal Year: 2007..So we propose to directly measure whether COG112 will exacerbate or ameliorate colitis in mouse models. [unreadable] [unreadable] [unreadable]..
- PI and Wnt Signaling in Postmortem Brain of Biopolar and Schizophrenia SubjectsGhanshyam N Pandey; Fiscal Year: 2011..This may eventually lead to i better understanding of the pathophysiology of BP or SZ illnesses and may aid in the development of more appropriate therapeutic agents for the treatment of these disorders. ..
- Protein Biomarker Profiles of Abusive Alcohol ConsumptionFrank Witzmann; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Prenatal Virally Induced Brain Disorder in MouseSEYYED FATEMI; Fiscal Year: 2009..In addition, it is expected that the results will provide clues that will lead to fundamental advances in our knowledge of the pathogenesis of schizophrenia and, therefore, of how it can be prevented and treated. ..
- Dispersion Patterns for Retinal NeuroblastsBENJAMIN REESE; Fiscal Year: 2009..abstract_text> ..
- Varenicline and Smoking Cessation in SchizophreniaSEYYED HOSSEIN FATEMI; Fiscal Year: 2010..Such outcomes will be significant, because they will offer a new treatment for smoking cessation in this vulnerable population. ..
- COMPLEMENT-MEDIATED NEURONAL INJURY IN STROKEEDWARD SANDER CONNOLLY; Fiscal Year: 2010....
- Meningioma: Risk Factors and Quality of LifeJOSEPH LEO WIEMELS; Fiscal Year: 2010..This study represents the first concentrated effort to examine environmental and genetic risk factors for meningioma. ..
- Mouse models for GABA epigenetic dysfunctionAlessandro Guidotti; Fiscal Year: 2009..abstract_text> ..
- Invasion of C. neoformans into brain endothelial cellsAmbrose Jong; Fiscal Year: 2008..The information derived from the studies is expected to be helpful in the development of novel strategies to prevent cryptococcal meningitis and its associated morbidity. ..
- TRAUMATIC BRAIN INJURY AND MARROW STROMAL CELLSAsim Mahmood; Fiscal Year: 2009..If the treatment combining MSCs with simvastatin is found to be more effective than monotherapy, this will increase the clinical relevance of MSC treatment by allowing us to use smaller and safer doses. ..
- Motherhood and Structural Plasticity in the HippocampusBenedetta Leuner; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- ENERGY METABOLISM, DOPAMINE NEURONS AND NEUROTOXICITYGail Zeevalk; Fiscal Year: 2008..The studies will have relevance to neurodegenerative conditions or pathophysiological situations in which metabolism is compromised. ..
- Rapid seizure-induced changes in dendritic spinesMichael Wong; Fiscal Year: 2007..Washington University possesses unmatched resources in cutting-edge technology and expert researchers in cellular imaging and represents an ideal environment for the PI to complete the goals of this proposal. ..
- Triple Transgenic Model of Alzheimer's DiseaseMICHAEL VITEK; Fiscal Year: 2006....
- Olympus FV 1000 Confocal Microscope for Neurobiology and Cellular Biology ResearcFrancisco Alvarez; Fiscal Year: 2006..unreadable] [unreadable] [unreadable]..
- ANIMAL MODEL OF ALZHEIMERS DISEASE PATHOLOGYMICHAEL VITEK; Fiscal Year: 2001..Should this be insufficient to produce PHF/NFT pathology, we will stress these animals in a variety of ways to predispose the formation and detection of PHF/NFT structures (Specific Aim 4). ..
- Microarrays for Alzheimer's Disease Mouse ModelsP Reddy; Fiscal Year: 2003..The outcome of this proposed investigation will be useful in screening several mitochondrial antioxidants in AD transgenic mouse models as pre-clinical trials of AD patients...
- MEDIC ONE STROKE SCALEDavid Tirschwell; Fiscal Year: 2003..As stroke therapeutic research moves into the prehospital setting, the MOSS will serve as a standardized evaluation tool allowing early and accurate stroke diagnosis and severity stratification. ..
- SUBMACULAR SURGERY TRIALS PATHOLOGY CENTERHans Grossniklaus; Fiscal Year: 2003..Additionally, eyes obtained post-mortem from patients enrolled in the SST will be studied for pathologic correlation with clinical findings and outcomes. ..
- Control of Eye Melanoma MetastasisHans Grossniklaus; Fiscal Year: 2003..Both the IFN and angiostatin will prevent the progression of micrometastases into metastases by anti-angiogenesis. Angiostatin will prevent metastases by an anti-melanoma invasion effect. ..
- HUMAN TYROSINE HYDROXYLASE AND SCHIZOPHRENIAJohn Haycock; Fiscal Year: 2003..age-matched, sudden-death control subjects having no Axis 1 mental disorder. Parallel, collaborative studies of major depressives will provide comparison groups and allow identification of potential disease-specific differences. ..
- Exacerbation of Alzheimer's Disease by Nitrous OxideW Kofke; Fiscal Year: 2003..Moreover, observation of a protective effect may result in discovery of an easily implemented preventative drug therapy for AD. ..
- MULTIFOCAL NEURODEGENERATION IN ALZHEIMER'S DISEASEBrent Vogt; Fiscal Year: 2002....
- PHARMACOLOGY--ALLOSTERIC MODULATORS OF GABAA RECEPTORSAlessandro Guidotti; Fiscal Year: 2002....
- The involvement of LIM kinase in metastasesOra Bernard; Fiscal Year: 2004..These experiments will allow us to establish the role of LIMK1 in metastases with the ultimate goal of using it for diagnosis of metastatic cancer and for developing compounds that inhibit the activity of this kinase. ..
- Stress and Sex Effects on Learning and Dendritic SpinesBenedetta Leuner; Fiscal Year: 2004..Thus, the goal of my proposal is to determine whether glucocorticoids in males and estrogen in females contribute to the sexually opposed stress on dendritic spine density. ..
- ROS Defense Mechanisms in Brain ReoxygenationSarah Milton; Fiscal Year: 2004....
- Demyelination Plus Transplantation to Study CNS RepairHans Keirstead; Fiscal Year: 2006..abstract_text> ..
- REELIN DEFICIENCY--MODEL FOR SCHIZOPHRENIA VULNERABILITYAlessandro Guidotti; Fiscal Year: 2004....
- Novel Intervention for Amyloid-Induced NeuroinflammationMICHAEL VITEK; Fiscal Year: 2007..If COG133 can reduce the brain inflammation, it may also improve the behavioral performance of these animals. Pu [unreadable] [unreadable] [unreadable]..
- IMPROVED ASSAYS FOR SPECIFICALLY MEASURING COLLAGENASE-3MICHAEL VITEK; Fiscal Year: 2004..This "assay" kit can then be used in arthritis and cancer by assessing disease progression. ..
- TREATMENT OF TRAUMATIC BRAIN INJURY WITH SIMVASTATINAsim Mahmood; Fiscal Year: 2009..abstract_text> ..
- CELLULAR REGULATION OF TYROSINE HYDROXYLASEJohn Haycock; Fiscal Year: 2001..The effects of haloperidol on Ser19, Ser3l, and Ser4O phosphorylation will be studied by immunohistochemical and blot immunolabeling procedures using site- and phosphorylation state-specific antibodies. ..
- OEC 9800 C-ARM - DIGITAL MOBILE IMAGING SYSTEME Connolly; Fiscal Year: 2003..In summary, high quality fluoroscopy, as provided by the OEC 9800 Digital Mobile Imaging System, is the most important means by which we can continue to refine the primate stroke model. ..
- MECHANISMS OF MEMORY DEFICITS FOLLOWING BRAIN INJURYPramod Dash; Fiscal Year: 2006..Furthermore, this project will broaden our understanding of the pathogenesis of neurodegenerative diseases such as stroke and Alzheimer's disease. ..
- LONG TERM HIPPOCAMPAL MEMORYPramod Dash; Fiscal Year: 2001..Understanding the molecular basis of memory storage will be of value in the future development of pharmacological agents to treat amnesia associated with neurological disorders and other mental health related problems. ..
- NITRIC OXIDE, PLP ACYLATION & THE PATHOPHYSIOLOGY OF MSOSCAR BIZZOZERO; Fiscal Year: 2003..abstract_text> ..
- Working memory deficits following brain traumaPramod Dash; Fiscal Year: 2009..An understanding of the mechanisms by which TBI alters dopamine signaling is critical for the development of mechanism-based intelligent pharmacological treatments for working memory deficits for brain trauma patients. ..
- MECHANISMS OF NO-MEDIATED PROTEIN S-NITROSYLATION IN EAEOSCAR BIZZOZERO; Fiscal Year: 2007..abstract_text> ..
- Prefrontal cortex and memory storagePramod K Dash; Fiscal Year: 2010....
- Reward comparison, drugs of abuse & the gustatory cortexRASTAFA GEDDES; Fiscal Year: 2004..Finally, Specific Aim III will determine whether an intact gustatory cortex is essential for retention of a preoperatively acquired association between the saccharin CS and the drug. ..
- Combination Therapy for Chronic Stroke-Induced ImpairmentJ Leigh Leasure; Fiscal Year: 2008..The proposed experiment will test a potential treatment for chronic stroke-related impairment in the aged brain. [unreadable] [unreadable] [unreadable]..
- ADENOSINE AND TRAUMATIC BRAIN INJURYPatrick Kochanek; Fiscal Year: 2007..These studies explore the most promising adenosine-based therapy for TBI-A2a receptor antagonists. Our bench to bedside track record ensures translation to the clinic. [unreadable] [unreadable]..
- REPRESENTATION OF SATIETY IN ORBITOFRONTAL CORTEXTHOMAS PRITCHARD; Fiscal Year: 2003..These data may expedite development of successful strategies for diagnosis and treatment of various eating and metabolic disorders. ..
- FUNCTION AND ASSEMBLY OF CO2 ASSIMILATORY ENZYMESF Tabita; Fiscal Year: 2005..Of particular interest will be the relationship of protein folding and catalysis to cellular function. ..
- MOLECULAR BASIS AND ENZYMOLOGY OF MICROBIAL BIOSYNTHESISF Tabita; Fiscal Year: 2003..For each enzyme, recombinant systems will be used to facilitate efforts to learn how these proteins function specifically in biosynthesis and how control of their activity influences normal cellular metabolism. ..
- Functional Aspects of Adult Hippocampal NeurogenesisJULIAN KEITH; Fiscal Year: 2007..abstract_text> ..