carbon oxygen ligases

Summary

Summary: Enzymes that catalyze the joining of two molecules by the formation of a carbon-oxygen bond. EC 6.1.

Top Publications

  1. ncbi Increasing rates of vancomycin resistance among Enterococcus faecium isolated from German hospitals between 2004 and 2006 are due to wide clonal dissemination of vancomycin-resistant enterococci and horizontal spread of vanA clusters
    Guido Werner
    Robert Koch Institute, Wernigerode Branch, D 38855 Wernigerode, Germany
    Int J Med Microbiol 298:515-27. 2008
  2. ncbi Glycopeptide resistance in enterococci
    M Arthur
    Unite des Agents Antibacteriens, Centre National de la Recherche Scientifique, EP J0058, Institut Pasteur, Paris, France
    Trends Microbiol 4:401-7. 1996
  3. ncbi Vancomycin-resistant Staphylococcus aureus in the United States, 2002-2006
    Dawn M Sievert
    Michigan Department of Community Health, Lansing, USA
    Clin Infect Dis 46:668-74. 2008
  4. ncbi PCR-based plasmid typing in Enterococcus faecium strains reveals widely distributed pRE25-, pRUM-, pIP501- and pHTbeta-related replicons associated with glycopeptide resistance and stabilizing toxin-antitoxin systems
    Torill C S Rosvoll
    Department of Medical Biology, University of Tromsø, Tromsø, Norway
    FEMS Immunol Med Microbiol 58:254-68. 2010
  5. pmc VanA-type vancomycin-resistant Staphylococcus aureus
    Bruno Perichon
    Institut Pasteur, Unite des Agents Antibacteriens, 25 rue du Docteur Roux, 75724 Paris Cedex 15, France
    Antimicrob Agents Chemother 53:4580-7. 2009
  6. ncbi High resolution crystal structure of a key editosome enzyme from Trypanosoma brucei: RNA editing ligase 1
    Junpeng Deng
    Howard Hughes Medical Institute, University of Washington, Seattle WA 98195, USA
    J Mol Biol 343:601-13. 2004
  7. pmc Vancomycin-resistant Staphylococcus aureus isolates associated with Inc18-like vanA plasmids in Michigan
    Wenming Zhu
    Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, 1600 Clifton Rd, MS G08, Atlanta, GA 30333, USA
    Antimicrob Agents Chemother 52:452-7. 2008
  8. pmc VanA-type enterococci from humans, animals, and food: species distribution, population structure, Tn1546 typing and location, and virulence determinants
    F Biavasco
    Institute of Microbiology and Biomedical Sciences, Polytechnic University of Marche, Via Ranieri, Monte D Ago, 60131 Ancona, Italy
    Appl Environ Microbiol 73:3307-19. 2007
  9. pmc An improved relaxed complex scheme for receptor flexibility in computer-aided drug design
    Rommie E Amaro
    Department of Chemistry and Biochemistry, University of California at San Diego, La Jolla, CA, 92093 0365, USA
    J Comput Aided Mol Des 22:693-705. 2008
  10. pmc Molecular diversity and evolutionary relationships of Tn1546-like elements in enterococci from humans and animals
    R J Willems
    Research Laboratory for Infectious Diseases, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    Antimicrob Agents Chemother 43:483-91. 1999

Research Grants

  1. HUMAN RETROVIRUS-5 AND ARTHRITIS
    Robin Patel; Fiscal Year: 2002
  2. Enhancement of antimicrobics by electrical current
    Robin Patel; Fiscal Year: 2007
  3. Detection of Biofilm Bacteria using GloBac
    Robin Patel; Fiscal Year: 2008
  4. The SMD-Relaxed Complex Method for Drug Design
    Rommie Amaro; Fiscal Year: 2008
  5. INVASION AND ADHESION OF PERIOPATHOGENS
    Keith Mintz; Fiscal Year: 2007

Detail Information

Publications167 found, 100 shown here

  1. ncbi Increasing rates of vancomycin resistance among Enterococcus faecium isolated from German hospitals between 2004 and 2006 are due to wide clonal dissemination of vancomycin-resistant enterococci and horizontal spread of vanA clusters
    Guido Werner
    Robert Koch Institute, Wernigerode Branch, D 38855 Wernigerode, Germany
    Int J Med Microbiol 298:515-27. 2008
    ..In conclusion, the increase in the rates of VREF among German hospital patients within the last 2 years might be rather complex and due to different molecular events and scenarios...
  2. ncbi Glycopeptide resistance in enterococci
    M Arthur
    Unite des Agents Antibacteriens, Centre National de la Recherche Scientifique, EP J0058, Institut Pasteur, Paris, France
    Trends Microbiol 4:401-7. 1996
    ....
  3. ncbi Vancomycin-resistant Staphylococcus aureus in the United States, 2002-2006
    Dawn M Sievert
    Michigan Department of Community Health, Lansing, USA
    Clin Infect Dis 46:668-74. 2008
    ....
  4. ncbi PCR-based plasmid typing in Enterococcus faecium strains reveals widely distributed pRE25-, pRUM-, pIP501- and pHTbeta-related replicons associated with glycopeptide resistance and stabilizing toxin-antitoxin systems
    Torill C S Rosvoll
    Department of Medical Biology, University of Tromsø, Tromsø, Norway
    FEMS Immunol Med Microbiol 58:254-68. 2010
    ..PCR-based replicon typing, linked to the detection of other important plasmid-encoded traits, seems to be a feasible tool for tracing disseminating resistance plasmids stably maintained in various environments...
  5. pmc VanA-type vancomycin-resistant Staphylococcus aureus
    Bruno Perichon
    Institut Pasteur, Unite des Agents Antibacteriens, 25 rue du Docteur Roux, 75724 Paris Cedex 15, France
    Antimicrob Agents Chemother 53:4580-7. 2009
    ..The association of multiple molecular and environmental factors has been implicated in the regional emergence of VRSA in Michigan...
  6. ncbi High resolution crystal structure of a key editosome enzyme from Trypanosoma brucei: RNA editing ligase 1
    Junpeng Deng
    Howard Hughes Medical Institute, University of Washington, Seattle WA 98195, USA
    J Mol Biol 343:601-13. 2004
    ....
  7. pmc Vancomycin-resistant Staphylococcus aureus isolates associated with Inc18-like vanA plasmids in Michigan
    Wenming Zhu
    Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, 1600 Clifton Rd, MS G08, Atlanta, GA 30333, USA
    Antimicrob Agents Chemother 52:452-7. 2008
    ..An Inc18-like vanA plasmid was identified in the VRSA isolate from case patient 7. These findings suggest a role of Inc18-like plasmids as vanA donors...
  8. pmc VanA-type enterococci from humans, animals, and food: species distribution, population structure, Tn1546 typing and location, and virulence determinants
    F Biavasco
    Institute of Microbiology and Biomedical Sciences, Polytechnic University of Marche, Via Ranieri, Monte D Ago, 60131 Ancona, Italy
    Appl Environ Microbiol 73:3307-19. 2007
    ....
  9. pmc An improved relaxed complex scheme for receptor flexibility in computer-aided drug design
    Rommie E Amaro
    Department of Chemistry and Biochemistry, University of California at San Diego, La Jolla, CA, 92093 0365, USA
    J Comput Aided Mol Des 22:693-705. 2008
    ..Finally, we outline potential methodological improvements that we anticipate will assist future development...
  10. pmc Molecular diversity and evolutionary relationships of Tn1546-like elements in enterococci from humans and animals
    R J Willems
    Research Laboratory for Infectious Diseases, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    Antimicrob Agents Chemother 43:483-91. 1999
    ..The genetic diversity in Tn1546 combined with epidemiological data suggest that the DNA polymorphism among Tn1546 variants can successfully be exploited for the tracing of the routes of transmission of vancomycin resistance genes...
  11. pmc Comparative DNA analysis of two vanA plasmids from Enterococcus faecium strains isolated from poultry and a poultry farmer in Norway
    H Sletvold
    Department of Pharmacy, Faculty of Medicine, University of Tromsø, and Department of Microbiology and Infection Control, University Hospital of North Norway, Tromsø, Norway
    Antimicrob Agents Chemother 51:736-9. 2007
    ..A postsegregational killing system was identified. This system possibly explains the persistence of the vanA gene cluster in Norwegian poultry farms...
  12. pmc Discovery of drug-like inhibitors of an essential RNA-editing ligase in Trypanosoma brucei
    Rommie E Amaro
    Department of Chemistry and Biochemistry and Center for Theoretical Biological Physics, University of California at San Diego, La Jolla, CA 92093 0365, USA
    Proc Natl Acad Sci U S A 105:17278-83. 2008
    ..These compounds are promising scaffolds for future drug design and discovery efforts against these important pathogens...
  13. pmc Persistence of animal and human glycopeptide-resistant enterococci on two Norwegian poultry farms formerly exposed to avoparcin is associated with a widespread plasmid-mediated vanA element within a polyclonal enterococcus faecium population
    P J Johnsen
    Department of Microbiology and Virology, Faculty of Medicine, University of Tromsø, N 9037 Tromsø, Norway
    Appl Environ Microbiol 71:159-68. 2005
    ..In addition, we propose that "plasmid addiction systems" may contribute to the persistence of GREF in nonselective environments...
  14. pmc The biopesticide Paenibacillus popilliae has a vancomycin resistance gene cluster homologous to the enterococcal VanA vancomycin resistance gene cluster
    R Patel
    Division of Infectious Diseases, Infectious Diseases Research Laboratory, Mayo Clinic and Foundation, Rochester, Minnesota, USA
    Antimicrob Agents Chemother 44:705-9. 2000
    ..The use of P. popilliae biopesticidal preparations in agricultural practice may have an impact on bacterial resistance in human pathogens...
  15. pmc Glycopeptide susceptibility among Danish Enterococcus faecium and Enterococcus faecalis isolates of animal and human origin and PCR identification of genes within the VanA cluster
    F M Aarestrup
    Danish Veterinary Laboratory, Copenhagen
    Antimicrob Agents Chemother 40:1938-40. 1996
    ..All vancomycin-resistant isolates examined carried the vanA, vanX, and vanR genes, suggesting that a gene cluster similar to that of the transposon Tn1546 was responsible for the resistance...
  16. ncbi Molecular characterization of clinical and environmental isolates of vancomycin-resistant Enterococcus faecium and Enterococcus faecalis from a teaching hospital in Wales
    Tomoari Kuriyama
    Department of Oral Surgery, Medicine and Pathology, Dental School, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XY, UK
    J Med Microbiol 52:821-7. 2003
    ..Predominance of a single pulsotype (not detected in the environment) amongst clinical isolates suggests non-environmental transmission between patients...
  17. ncbi Molecular alterations of VanA element in vancomycin-resistant enterococci isolated during a survey of colonized patients in an Italian intensive care unit
    Floriana Campanile
    Department of Microbiological and Gynecological Sciences, University of Catania, 95124 Catania, Italy
    Microb Drug Resist 9:191-9. 2003
    ..Moreover, isolates with identical PFGE types may contain different VanA elements reflecting rearrangements mediated by insertion sequences in VRE strains during their stay in the gastrointestinal tract...
  18. ncbi Clinical implications of vancomycin-resistant Enterococcus faecium (VRE) with VanD phenotype and vanA genotype
    Jae Hoon Song
    Division of Infectious Diseases, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    J Antimicrob Chemother 61:838-44. 2008
    ..To investigate the clinical implications of vancomycin-resistant Enterococcus faecium (VRE) with VanD phenotype and vanA genotype (VanD-vanA VRE)...
  19. ncbi Emerging vancomycin resistance in enterococci in India
    Ujjala Ghoshal
    Department of Microbiology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow 226014
    Indian J Pathol Microbiol 49:620-2. 2006
    ..Emergence of vancomycin resistant enterococci is of great concern because of its epidemic potential and scanty therapeutic options. Prompt diagnosis and efficient infection control measures can restrict its spread...
  20. pmc Vancomycin resistance is maintained in enterococci in the viable but nonculturable state and after division is resumed
    Maria Mar Lleò
    Dipartimento di Patologia Sezione di Microbiologia, Universita di Verona, Italy
    Antimicrob Agents Chemother 47:1154-6. 2003
    ..During restoration of division they continue to express the vancomycin resistance trait. We suggest that VBNC enterococci may constitute further reservoirs of VRE and therefore represent an additional risk for human health...
  21. ncbi Dissemination of vancomycin-resistant enterococci harboring vanA through disposal of waste derived from industrial production of vancomycin
    L Guardabassi
    Department of Veterinary Microbiology, The Royal Veterinary and Agricultural University, 1870 Frederiksberg C, Denmark
    Microb Drug Resist 8:401-6. 2002
    ..These results indicate the need to assess the possible dissemination of VRE and other antibiotic-resistant bacteria through disposal of waste derived from antibiotic production...
  22. pmc Characterization of Tn1546 in vancomycin-resistant Enterococcus faecium isolated from canine urinary tract infections: evidence of gene exchange between human and animal enterococci
    S Simjee
    Center for Veterinary Medicine, U S Food and Drug Administration, Laurel, Maryland 20708, USA
    J Clin Microbiol 40:4659-65. 2002
    ..Additionally, this is the first report of a vancomycin-resistant E. faecium isolated from a companion animal in the United States...
  23. ncbi Outbreak of hospital-adapted clonal complex-17 vancomycin-resistant Enterococcus faecium strain in a haematology unit: role of rapid typing for early control
    A Deplano
    Department of Microbiology, Erasme Hospital, Universite Libre de Bruxelles, Brussels, Belgium
    J Antimicrob Chemother 60:849-54. 2007
    ..To describe the investigation and molecular characterization of a vancomycin-resistant Enterococcus faecium (VREF) strain responsible for a nosocomial outbreak in the haematology unit of a tertiary-care university hospital...
  24. pmc Emergence of vanA Genotype Vancomycin-Resistant Enterococci with Low or Moderate Levels of Teicoplanin Resistance in Korea
    Joong Sik Eom
    Department of Internal Medicine, Kangdong Sacred Heart Hospital, College of Medicine, Hallym University, Seoul, Republic of Korea
    J Clin Microbiol 42:1785-6. 2004
    ..In 2001, we experienced an outbreak of VanB phenotype-vanA genotype vancomycin-resistant enterococci at a university hospital. This is the first report of VanB-vanA vancomycin-resistant enterococci from humans in Korea...
  25. ncbi Rapid detection and differentiation method of VanA, VanB and VanC phenotypes in vancomycin-resistant enterococci
    Hideaki Hanaki
    Laboratory of Clinical Bacteriology, Department Nutrition Nakamuragakuen University, 5 7 1 Befu, Jyonan ku, Fukuoka, Japan
    Int J Antimicrob Agents 23:502-5. 2004
    ..We compared our simple method with the PCR method in 43 strains of vanA-VRE, 35 strains of vanB-VRE and 37 strains of vanC-VRE. The results were 100% consistent with that obtained by PCR...
  26. pmc Occurrence, structure, and mobility of Tn1546-like elements in environmental isolates of vancomycin-resistant enterococci
    L Guardabassi
    Department of Veterinary Microbiology, The Royal Veterinary and Agricultural University, 1870 Frederiksberg, Denmark
    Appl Environ Microbiol 70:984-90. 2004
    ....
  27. ncbi Identification of an unusual VanA element in glycopeptide-resistant Enterococcus faecium in Brazil following international transfer of a bone marrow transplant patient
    I L B C Camargo
    Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Brazil
    Can J Microbiol 50:767-70. 2004
    ..The genotype and association with a patient previously treated in the USA suggest that this VRE was introduced from abroad, probably through inter-hospital strain spread...
  28. ncbi Heteroresistance to vancomycin and novel point mutations in Tn1546 of Enterococcus faecium ATCC 51559
    Saeed A Khan
    Division of Microbiology, National Center for Toxicological Research FDA, 3900 NCTR Road, Jefferson, AR 72079, USA
    Int J Antimicrob Agents 31:27-36. 2008
    ..The present study clearly shows how independent novel mutations can give rise to polymorphism, heteroresistance and clonal diversity among vancomycin-resistant enterococci strains as a result of continuous exposure to antibiotics...
  29. pmc In vitro activity of daptomycin against vancomycin-resistant enterococci of various Van types and comparison of susceptibility testing methods
    James H Jorgensen
    Department of Pathology, The University of Texas Health Science Center, San Antonio, Texas 78229, USA
    Antimicrob Agents Chemother 47:3760-3. 2003
    ..However, improved standardization of the calcium content of MH agar will be important for reliable testing of daptomycin by clinical laboratories using either the E test or disk diffusion methods...
  30. ncbi Molecular characterization of vancomycin-resistant enterococci in Hangzhou, China
    Ting Ting Qu
    J Antimicrob Chemother 60:1403-5. 2007
  31. ncbi Failure of daptomycin monotherapy for endocarditis caused by an Enterococcus faecium strain with vancomycin-resistant and vancomycin-susceptible subpopulations and evidence of in vivo loss of the vanA gene cluster
    Cesar A Arias
    Center for the Study of Emerging and Reemerging Pathogens, Division of Infectious Diseases, The University of Texas Medical School, Houston, TX 77030, USA
    Clin Infect Dis 45:1343-6. 2007
    ..The infecting organism exhibited in vivo emergence of a vancomycin-susceptible subpopulation lacking vanA. Treatment with a combination of high-dose daptomycin, gentamicin, and high-dose ampicillin cleared the infection...
  32. pmc Distribution of insertion sequences associated with Tn1546-like elements among Enterococcus faecium isolates from patients in Korea
    Ji Young Huh
    Department of Laboratory Medicine, Ajou University School of Medicine, Suwon, Korea
    J Clin Microbiol 42:1897-902. 2004
    ..In addition, the distribution of ISs associated with Tn1546-like elements among the Korean isolates is therefore similar to that among European vancomycin-resistant enterococci...
  33. ncbi Microbiological and epidemiological studies of Enterococcus faecium resistant to amoxycillin in a university hospital in eastern France
    M Thouverez
    Service d Hygiène Hospitalière et d Épidémiologie Moléculaire, Centre Hospitalier Universitaire Jean Minjoz, Besancon, France
    Clin Microbiol Infect 10:441-7. 2004
    ..Three epidemic patterns were identified which contained 87.5% (28/32) of the AmRE isolates, indicating that clonal spread was responsible, at least partially, for the high incidence of AmRE in this hospital...
  34. pmc Detection and typing of vancomycin-resistance genes of enterococci from clinical and nosocomial surveillance specimens by multiplex PCR
    J J Lu
    Department of Pathology, Tri-Service General Hospital and National Defense Medical Center, Taipei, Taiwan
    Epidemiol Infect 126:357-63. 2001
    ..9% and 100%, respectively. The results suggest that genotypic characterization of vancomycin-resistance is necessary for all clinical VRE isolates and that the multiplex PCR assay can be an alternative method for this purpose...
  35. ncbi Evaluation of the EVIGENE VRE detection kit for detection of vanA and vanB genes in vancomycin-resistant enterococci
    Abdullah Kilic
    Department of Microbiology and Clinical Microbiology, Gulhane Military Medical Academy and School of Medicine, 06018, Ankara, Turkey
    J Med Microbiol 54:347-50. 2005
    ....
  36. ncbi Dalbavancin activity against selected populations of antimicrobial-resistant Gram-positive pathogens
    Jennifer M Streit
    The JONES Group JMI Laboratories, North Liberty, IA 52317, USA
    Diagn Microbiol Infect Dis 53:307-10. 2005
    ..In summary, dalbavancin was very active against a wide spectrum of resistant Gram-positive isolates and demonstrated greater potency than vancomycin or teicoplanin...
  37. ncbi High frequency of vancomycin-resistant Enterococcus faecium isolates with VanB phenotype and vanA genotype in Korean hospitals
    Jae Hoon Song
    Asian Pacific Research Foundation for Infectious Diseases CARFID, Seoul 135 710, South Korea
    Diagn Microbiol Infect Dis 56:401-6. 2006
    ..Data showed a relatively high frequency of VREF isolates with incongruence between phenotype and genotype for glycopeptide resistance in Korean hospitals...
  38. ncbi Molecular epidemiology of vancomycin-resistant Enterococcus faecium in Argentina
    Alejandra C Corso
    Servicio Antimicrobianos, Instituto Nacional de Enfermedades Infecciosas ANLIS Dr Carlos G Malbran, Av Velez Sarsfield 563 1281, Buenos Aires, Argentina
    Int J Infect Dis 11:69-75. 2007
    ..To characterize the mechanism of glycopeptide resistance and to determine the genetic relatedness among strains by pulsed-field gel electrophoresis (PFGE) in vancomycin-resistant Enterococcus faecium from Argentina...
  39. ncbi Emergence of vancomycin-resistant Enterococcus faecium at a tertiary care hospital in Karachi, Pakistan
    E Khan
    Dept of Pathology, The Aga Khan University Hospital, Karachi, Pakistan
    J Hosp Infect 52:292-6. 2002
    ..Use of vancomycin and prolonged hospitalization were common features in all cases investigated...
  40. ncbi Molecular analysis of vanA enterococci isolated from humans and animals in northeastern Italy
    M G Bonora
    Department of Pathology, Section of Microbiology, University of Verona, Italy
    Microb Drug Resist 7:247-56. 2001
    ..A total of 84.6% of animal strains and 64.2% of human strains contained elements indistinguishable from the prototype Tn1546. In addition, nine different types were identified, but none was common to animal and human strains...
  41. ncbi [Molecular analysis of vancomycin-resistant enterococci isolated from clinical samples]
    Abdullah Kilic
    GATA Mikrobiyoloji ve Klinik Mikrobiyoloji Anabilim Dall, Etlik, Ankara
    Mikrobiyol Bul 40:295-9. 2006
    ..As a result, VanA carrying VRE cause sporadic infections in our hospital. The molecular epidemiologic investigation of resistant microorganisms is important in terms of infection control and epidemiology...
  42. pmc A 24-hour screening protocol for identification of vancomycin-resistant Enterococcus faecium
    Steven J Drews
    Department of Paediatric Laboratory Medicine, The Hospital for Sick Children, 555 University Ave, Room 3654, Toronto, Ontario M5G 1X8, Canada
    J Clin Microbiol 44:1578-80. 2006
    ..Compared to conventional screening methods, this protocol had a high sensitivity and specificity and a negative predictive value...
  43. pmc Diversity of Tn1546 elements in clinical isolates of glycopeptide-resistant enterococci from Scottish hospitals
    A R Brown
    Department of Medical Microbiology, University of Edinburgh, Edinburgh, United Kingdom
    Antimicrob Agents Chemother 45:1309-11. 2001
    ..A putative hybrid promoter was identified, generated upstream of vanR by the insertion of IS1542. The presence of this hybrid promoter was associated with constitutive expression of the van genes and elevated teicoplanin resistance...
  44. pmc Evaluation of a rapid direct assay for identification of bacteria and the mec A and van genes from positive-testing blood cultures
    U Eigner
    Department of Microbiology and Hygeine, Limbach Laboratory, Robert Koch Institute, Im Breitspiel 15, D 69126 Heidelberg, Germany
    J Clin Microbiol 43:5256-62. 2005
    ..The evaluated GenoType blood culture assay showed fast and reliable results in detecting the most important sepsis pathogens and the mec A and van genes directly from positive blood culture bottles...
  45. ncbi Molecular and functional characterization of O antigen transfer in Vibrio cholerae
    Stefan Schild
    Institut für Hygiene und Mikrobiologie, Universitat Wurzburg, Josef Schneider Strasse 2, E1, Wurzburg 97080, Germany
    J Biol Chem 280:25936-47. 2005
    ..Moreover, analogy of topology and motifs between WaaLs and O polysaccharide polymerases (Wzy) reveals a relationship between the two protein families, suggesting that the catalyzed reactions are related to each other...
  46. pmc Absence of VanA- and VanB-containing enterococci in poultry raised on nonintensive production farms in Brazil
    Diego Batista Xavier
    Microbiologia Molecular and Biotecnología, Universidade de Brasilia, Faculdade de Agronomia e Medicina Veterinaria, C Postal 04508, CEP 70910 900 Brasília DF, Brazil
    Appl Environ Microbiol 72:3072-3. 2006
    ..No VanA- or VanB-containing enterococci were identified in a total of 200 cloacal swabs. The most prevalent species were Enterococcus gallinarum (vanC1; 13.0%) and E. casseliflavus (vanC2/3; 5.5%)...
  47. ncbi [Environmental contamination during a vancomycin-resistant Enterococci outbreak at a hospital in Argentina]
    Mariela Soledad Zárate
    Laboratorio de Bacteriologia, Micología y Parasitología Centro de Educación Médica e Investigaciones Clínicas Norberto Quirno CEMIC Capital Federal Buenos Aires Argentina
    Enferm Infecc Microbiol Clin 25:508-12. 2007
    ..The aims of this study were to report the first VRE outbreak in our center and assess the role of environmental contamination and HCW hands in the spread of new cases of enterococcal infection...
  48. ncbi Trends in antimicrobial resistance of clinical isolates of Enterococcus faecalis and Enterococcus faecium in Greece between 2002 and 2007
    E Protonotariou
    Department of Microbiology, Hippokration University Hospital, Thessaloniki, Greece
    J Hosp Infect 75:225-7. 2010
    ..0001). Regardless of these alarming trends, strains exhibiting resistance to oxazolidinones seem to be only sporadic in our region and a trend toward increasing resistance rates to glycopeptides was not detected...
  49. ncbi Outcome of a screening program for vancomycin-resistant enterococci in a hospital in Victoria
    M L Grayson
    Infectious Disease and Clinical Epidemiology Department, Monash Medical Center, Melbourne, Vic
    Med J Aust 171:133-6. 1999
    ..To screen for faecal colonisation with vancomycin-resistant enterococci (VRE) among potentially at-risk patients...
  50. ncbi The first molecular analysis of clinical isolates of VanA-type vancomycin-resistant Enterococcus faecium strains in Mainland China
    B Zheng
    Institute of Clinical Pharmacology, Peking University First Hospital, Beijing, China
    Lett Appl Microbiol 45:307-12. 2007
    ..This is the first molecular analysis of clinical VRE strains being isolated in mainland China...
  51. pmc Feature extraction and signal processing for nylon DNA microarrays
    F Lopez
    TAGC, INSERM ERM 206, Parc Scientifique de Luminy, 13288 Marseille, France
    BMC Genomics 5:38. 2004
    ..Variation in feature location or in signal integration methodology may be a significant contribution to the observed variance in gene expression levels...
  52. ncbi Phenotypes and genotypes of vancomycin-resistant enterococci isolated during long-term follow-up in a patient with recurrent bacteremia and colonization
    Kuo Ming Yeh
    Division of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC
    J Microbiol Immunol Infect 35:243-8. 2002
    ..Precautions against resistant organisms, adapted antibiotic policies, and elimination of patient carriage are useful for controlling the spread of vancomycin-resistant enterococci...
  53. ncbi Clonal dissemination of VanA-type glycopeptide-resistant Enterococcus faecalis between hospitals of two cities located 100 km apart
    M L Moretti
    Laboratório de Epidemiologia Molecular e Moléstias Infecciosas, Divisão de Moléstias Infecciosas, Faculdade de Ciencias Medicas, Universidade Estadual de CampinasCampinas, SP, Brasil
    Braz J Med Biol Res 37:1339-43. 2004
    ....
  54. pmc Specificity of induction of the vanA and vanB operons in vancomycin-resistant enterococci by telavancin
    Craig M Hill
    Molecular and Cellular Biology Department, Theravance, Inc, 901 Gateway Blvd, South San Francisco, CA 94080, USA
    Antimicrob Agents Chemother 54:2814-8. 2010
    ....
  55. pmc Molecular analysis of Tn1546 in Enterococcus faecium isolated from animals and humans
    L B Jensen
    Danish Veterinary Laboratory, Copenhagen V
    J Clin Microbiol 36:437-42. 1998
    ..faecium organisms of human and animal origins or the existence of a common reservoir for glycopeptide resistance...
  56. ncbi Case report vancomycin -resistant Enterococcus faecium VanA phenotype: first documented isolation in India
    Srujana Mohanty
    Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India
    Southeast Asian J Trop Med Public Health 37:335-7. 2006
    ..The child probably died due to sepsis from this highly resistant organism. To the best of our knowledge, this is the first reported isolation of VanA phenotype Enterococcus faecium in India...
  57. ncbi Enterococcus gallinarum carrying the vanA gene cluster: first report in Brazil
    I L B C Camargo
    Departamento de Analises Clinicas, Toxicologicas e Bromatologicas, Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, SP, Brasil
    Braz J Med Biol Res 37:1669-71. 2004
    ..faecalis JH22 as receptors. This is the first report of the detection of a vanA determinant naturally acquired by E. gallinarum in Brazil, indicating the importance of characterizing VRE by both phenotype and genotype methods...
  58. pmc Penicillin-binding protein 2 is essential for expression of high-level vancomycin resistance and cell wall synthesis in vancomycin-resistant Staphylococcus aureus carrying the enterococcal vanA gene complex
    Anatoly Severin
    The Rockefeller University, New York, New York 10021, USA
    Antimicrob Agents Chemother 48:4566-73. 2004
    ..aureus (A. Severin, K. Tabei, F. Tenover, M. Chung, N. Clarke, and A. Tomasz, J. Biol. Chem. 279:3398-3407, 2004) is penicillin binding protein 2...
  59. pmc Glycosylation of the collagen adhesin EmaA of Aggregatibacter actinomycetemcomitans is dependent upon the lipopolysaccharide biosynthetic pathway
    Gaoyan Tang
    Department of Microbiology and Molecular Genetics, Room 118, Stafford Hall, University of Vermont, Burlington, VT 05405, USA
    J Bacteriol 192:1395-404. 2010
    ..These data provide experimental evidence for the glycosylation of an oligomeric, coiled-coil adhesin and for the dependence of the posttranslational modification of EmaA on the LPS biosynthetic machinery in A. actinomycetemcomitans...
  60. pmc Physical mapping of bchG, orf427, and orf177 in the photosynthesis gene cluster of Rhodobacter sphaeroides: functional assignment of the bacteriochlorophyll synthetase gene
    H A Addlesee
    Robert Hill Institute for Photosynthesis and Krebs Institute for Biomolecular Research, Department of Molecular Biology and Biotechnology, University of Sheffield, United Kingdom
    J Bacteriol 182:3175-82. 2000
    ..The function of the remaining ORF, bchP, is the subject of a separate paper (H. Addlesee and C. N. Hunter, J. Bacteriol. 181:7248-7255, 1999). An operonal arrangement of the genes is proposed...
  61. ncbi Characterization of two phases of chlorophyll formation during greening of etiolated barley leaves
    Vladimir Domanskii
    Institute of Photobiology of the National Academy of Sciences of Belarus, Akademicheskaya 27, 220072 Minsk, Belarus
    Planta 216:475-83. 2003
    ..The existence of subcomplexes of prolamellar bodies containing NADPH:protochlorophyllide oxidoreductase and chlorophyll synthase in the ratio 7:1 is discussed...
  62. ncbi Persistence of vancomycin-resistant enterococci (VRE) in broiler houses after the avoparcin ban
    O E Heuer
    Danish Veterinary Institute, Department of Poultry, Fish and Fur Animals, DK 8200, Arhus N, Denmark
    Microb Drug Resist 8:355-61. 2002
    ..Thus, the extensive occurrence of VRE in broiler flocks after the avoparcin ban may be explained by persistence of VRE in the broiler house environment...
  63. ncbi Genetic diversity of Tn1546-like elements in clinical isolates of vancomycin-resistant enterococci
    Kidon Sung
    Division of Microbiology, National Center for Toxicological Research FDA, 3900 NCTR Road, Jefferson, AR 72079, USA
    Int J Antimicrob Agents 31:549-54. 2008
    ..Translocation of Tn1546 to a pRUM-like plasmid in VRE3 resulted in the loss of its orf1, orf2, vanR and vanS elements and a loss of the orf32 of pRUM, leading to a unique structural arrangement of vanA elements that is hitherto unknown...
  64. ncbi VanA-mediated high level glycopeptide resistance in MRSA
    Bruno Gonzalez-Zorn
    Lancet Infect Dis 3:67-8. 2003
  65. ncbi Evaluation of selective and enrichment media for isolation of glycopeptide-resistant enterococci from faecal specimens
    Derek F J Brown
    Clinical Microbiology and Public Health Laboratory, Addenbrooke s Hospital, Cambridge CB2 2QW, UK
    J Antimicrob Chemother 51:289-96. 2003
    ..The media were compared with enterococcosel broth (EB) and enterococcosel agar with vancomycin 6 mg/L (EA) for the isolation of glycopeptide-resistant enterococci (GRE) from routine faecal screening specimens...
  66. ncbi Cloning and characterisation of chlorophyll synthase from Avena sativa
    H C Schmid
    , Germany
    Biol Chem 382:903-11. 2001
    ..The role of the various Arg and Cys residues is discussed...
  67. ncbi Analysis of VanA vancomycin-resistant Enterococcus faecium isolates from Saudi Arabian hospitals reveals the presence of clonal cluster 17 and two new Tn1546 lineage types
    Mushtaq A Khan
    Department of Medical Microbiology and Infectious Diseases, Erasmus MC, s Gravendijkwal 230, 3015CE Rotterdam, The Netherlands
    J Antimicrob Chemother 62:279-83. 2008
    ..The aim of this study was to characterize 34 vancomycin-resistant VanA Enterococcus faecium isolates obtained from two hospitals in Saudi Arabia and to assess Tn1546 variation within these isolates...
  68. ncbi Prostaglandylinositol cyclic phosphate synthase activity in the liver of insulin-resistant rhesus monkeys before and after a euglycemic hyperinsulinemic clamp
    P N Shashkin
    Obesity and Diabetes Research Center, Department of Physiology, University of Maryland School of Medicine, Baltimore 21201, USA
    J Basic Clin Physiol Pharmacol 12:1-18. 2001
    ..94, p<0.005. The findings suggest that in the liver of insulin-resistant rhesus monkeys, cPIP synthase activity, which leads to the synthesis of the low-molecular weight mediator cPIP, may oppose cAMP synthesis and PKA activity...
  69. pmc Vancomycin-resistant enterococcal bacteremia in a hematology unit: molecular epidemiology and analysis of clinical course
    Jin Hong Yoo
    Department of Internal Medicine, The Catholic Haematopoietic Stem Cell Transplantion Center, The Catholic University of Korea, Seoul 105 010, Korea
    J Korean Med Sci 20:169-76. 2005
    ..5%) noted in VSE bacteremia. Initial disease severity and neutropenic status may be major determinants of prognosis in patients with VRE bacteraemia...
  70. ncbi Identification and characterization of enterococci from bryndza cheese
    D Jurkovic
    Institute of Cell Biology, Faculty of Natural Sciences, Comenius University, Bratislava, Slovak Republic
    Lett Appl Microbiol 42:553-9. 2006
    ....
  71. ncbi Genetic analysis of a high-level vancomycin-resistant isolate of Staphylococcus aureus
    Linda M Weigel
    Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Science 302:1569-71. 2003
    ..Genetic analyses suggest that the long-anticipated transfer of vancomycin resistance to a methicillin-resistant S. aureus occurred in vivo by interspecies transfer of Tn1546 from a co-isolate of Enterococcus faecalis...
  72. pmc Impact of flavophospholipol and vancomycin on conjugational transfer of vancomycin resistance plasmids
    S Riedl
    Institute for Molecular Biology of Infectious Diseases, The University of Würzburg, D 97070 Wurzburg, Germany
    Antimicrob Agents Chemother 44:3189-92. 2000
    ..FPL significantly inhibited the frequency of transfer of conjugative VanA plasmids up to 70-fold. Vancomycin had no significant effect on the transfer rate of VanA plasmids...
  73. ncbi Epidemiological, microbiological, clinical, and prognostic factors of bacteremia caused by high-level vancomycin-resistant Enterococcus species
    V Peset
    Microbiology Department, Hospital Universitario La Fe de Valencia, Spain
    Eur J Clin Microbiol Infect Dis 19:742-9. 2000
    ..This is believed to be the first and only such outbreak described in a Spanish hospital thus far...
  74. ncbi Occurrence of vancomycin-resistant enterococci in humans and animals in the Czech Republic between 2002 and 2004
    Milan Kolar
    Institute of Microbiology, Faculty of Medicine, Palacky University, Hnevotinska 3, 775 15, Olomouc, Czech Republic
    J Med Microbiol 54:965-7. 2005
    ..Most (54.5 %) were identified as VanA E. faecium. Cluster analysis of SmaI-generated macrorestriction patterns showed high variability in both human and animal VRE strains and no relatedness between strains from the two sources...
  75. ncbi Enzymes of the last steps of chlorophyll biosynthesis: modification of the substrate structure helps to understand the topology of the active centers
    Wolfhart Rüdiger
    Department Biology I, Botany, University of München, Menzingerstrasse 67, D 80638 München, Germany
    Biochemistry 44:10864-72. 2005
    ....
  76. ncbi Vancomycin resistant enterococci (VRE) still persist in slaughtered poultry in hungary 8 years after the ban on avoparcin
    A Ghidán
    Institute of Medical Microbiology, Semmelweis University, Nagyvarad ter 4, H 1089 Budapest, Hungary
    Acta Microbiol Immunol Hung 55:409-17. 2008
    ..The farms that produced these strains can be reservoirs of VRE and the affected farms should change the technology of disinfection and breeding in order to prevent the emergence of high numbers of human VRE isolates in Hungary...
  77. ncbi VanB-vanA incongruent VRE isolated from animals and humans in 1999
    Enjoo Shin
    Department of Biology, Culture Collection of Antimicrobial Resistant Microbes, Seoul Women s University, Seoul 139 774, Republic of Korea
    J Microbiol 44:453-6. 2006
    ..Pulsed-field gel electrophoresis revealed only a peripheral relationship between the chicken isolates and clinical isolates, but suggested clonal spread in the chicken isolates...
  78. ncbi Comparative study of vanA gene transfer from Enterococcus faecium to Enterococcus faecalis and to Enterococcus faecium in the intestine of mice
    Nadège Bourgeois-Nicolaos
    Laboratoire de Microbiologie, UFR des Sciences Pharmaceutiques et Biologiques, Universite Rene Descartes, Paris, France
    FEMS Microbiol Lett 254:27-33. 2006
    ..faecium to human E. faecalis in vitro and in vivo in the intestine of dibiotic mice. However, intraspecies transfer of vanA gene seems more common than interspecies transfer among enterococci...
  79. ncbi Transfer of plasmid and chromosomal glycopeptide resistance determinants occurs more readily in the digestive tract of mice than in vitro and exconjugants can persist stably in vivo in the absence of glycopeptide selection
    Kristin Hegstad Dahl
    Department of Microbiology and Virology, University of Tromsø, Tromsø, Norway
    J Antimicrob Chemother 59:478-86. 2007
    ..Moreover, the stability of exconjugants in vivo in the absence of antibiotic selection was examined...
  80. ncbi Screening for vancomycin-resistant enterococci: results of a survey in Stockholm
    Hong Fang
    Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska University Hospital Huddinge, Karolinska Institute, Stockholm, Sweden
    APMIS 118:413-7. 2010
    ..PFGE type 1 and PFGE type 2 were predominant clones in vanB and vanA strains, respectively, represented by 98.3% (59/60) of patients with vanB VRE and 77.4% (24/31) of patients with vanA VRE...
  81. pmc A fluorescence-based reporter substrate for monitoring RNA editing in trypanosomatid pathogens
    Houtan Moshiri
    Institute of Parasitology, McGill University, 21111 Lakeshore Road, Ste Anne de Bellevue, Montreal, Quebec H9X3V9, Canada
    Nucleic Acids Res 38:e138. 2010
    ..brucei. These inhibitors could also be tested against the editosomes from the closely related pathogens including T. cruzi and Leishmania species...
  82. ncbi Analysis of methods commonly used for glycopeptide and oxazolidinone susceptibility testing in Enterococcus faecium isolates
    Giammarco Raponi
    Dipartimento di Scienze di Sanità Pubblica, Sapienza University of Rome, Rome, Italy
    J Med Microbiol 59:672-8. 2010
    ..Therefore, the resistance to glycopeptides and linezolid was not univocally detected by the susceptibility testing methods used in this study...
  83. ncbi Elimination of vancomycin-resistant enterococci from a neonatal intensive care unit following an outbreak
    Z Ergaz
    Department of Neonatology, Hadassah Hebrew University Medical Centre, Jerusalem, Israel
    J Hosp Infect 74:370-6. 2010
    ..Early intensive intervention was associated with disappearance of the organism from the neonatal intensive care unit. No further cases of colonisation or disease have occurred in the unit in the two and a half years since then...
  84. ncbi [Epidemiological search for vancomycin-resistant enterococci in mainland of the Ryukyus]
    Kyoko Kisanuki
    Clinical Laboratories, University Hospital of the Ryukyus, University of the Ryukyus, Nishihara, Nakagami Okinawa, Japan
    Rinsho Biseibutshu Jinsoku Shindan Kenkyukai Shi 19:1-6. 2008
    ..With these results, it can be concluded that, at present, mainland of the Ryukyus is VRE-free area, and it is necessary to continue careful search for incoming and spreading of VRE positive for vanA and vanB genes in Okinawa...
  85. pmc Uridine insertion/deletion RNA editing in trypanosomatid mitochondria: In search of the editosome
    Daren Osato
    Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA
    RNA 15:1338-44. 2009
    ..We suggest that the L*b-complexes may provide a scaffold for dynamic interaction with other editing factors during the editing process to form the active holoenzyme or "editosome."..
  86. pmc Fitness cost of VanA-type vancomycin resistance in methicillin-resistant Staphylococcus aureus
    Marie Laure Foucault
    Unite des Agents Antibacteriens, Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris Cedex 15, France
    Antimicrob Agents Chemother 53:2354-9. 2009
    ..Thus, the potential for the dissemination of VRSA clinical isolates should not be underestimated...
  87. ncbi Genetic characterization of vancomycin-resistant enterococci isolates from wild rabbits
    Nicholas Figueiredo
    Departamento de Ciências Veterinárias, Universidade de Tras os Montes e Alto Douro, Vila Real, Portugal
    J Basic Microbiol 49:491-4. 2009
    ..The two remaining isolates (van C-1, van C-2/3) did not show resistance for any additional antibiotic. The intestinal tract of wild rabbits could be a reservoir of van A-containing enterococci...
  88. ncbi Spread without known selective pressure of a vancomycin-resistant clone of Enterococcus faecium among broilers
    O Nilsson
    National Veterinary Institute, Uppsala, Sweden
    J Antimicrob Chemother 63:868-72. 2009
    ..The aim of this paper was to describe an increased occurrence of vancomycin-resistant enterococci (VRE) in Swedish broilers since 2000 and to investigate the genetic relatedness of isolates...
  89. pmc D-alanylation of lipoteichoic acid contributes to the virulence of Streptococcus suis
    Nahuel Fittipaldi
    Groupe de Recherche sur les Maladies Infectieuses du Porc and Centre de Recherche en Infectiologie Porcine, Faculte de Medecine Veterinaire, Universite de Montreal, St Hyacinthe, QC J2S 7C6, Canada
    Infect Immun 76:3587-94. 2008
    ..The results of this study suggest that LTA D-alanylation is an important factor in S. suis virulence...
  90. ncbi MLST and a genetic study of antibiotic resistance and virulence factors in vanA-containing Enterococcus from buzzards (Buteo buteo)
    H Radhouani
    Institute for Biotechnology and Bioengineering, University of Tras os Montes and Alto Douro, Vila Real, Portugal
    Lett Appl Microbiol 50:537-41. 2010
    ..To analyse the occurrence of faecal carriage of vancomycin-resistant enterococci (VRE) in Buteo buteo and to study the associated resistance and virulence genes...
  91. ncbi Characterization of vanA-containing Enterococcus faecium isolates carrying Tn5397-like and Tn916/Tn1545-like transposons in wild boars (Sus Scrofa)
    Patricia Poeta
    University of Tras os Montes and Alto Douro, Veterinary Science Department, Vila Real, Portugal
    Microb Drug Resist 13:151-6. 2007
    ..The two vanA-containing isolates harbored the Tn916/Tn1545-like mobile element, and the Tn5397-like transposon was also found in isolate PG48V. The intestinal tract of wild boars could be a reservoir of vanA-containing enterococci...
  92. ncbi [Investigation of phenotypic and genotypic characteristics of vancomycin-resistant Enterococcus faecium isolates]
    Zerrin Aktas
    Istanbul Universitesi Istanbul Tip Fakultesi, Mikrobiyoloji ve Klinik Mikrobiyoloji Anabilim Dali, Istanbul
    Mikrobiyol Bul 41:347-56. 2007
    ..According to these results, the spread of VRE within our hospital was considered as a polyclonal dissemination...
  93. pmc Genetic rearrangements of TN1546-like elements in vancomycin-resistant Enterococcus faecium isolates collected from hospitalized patients over a seven-year period
    Il Joong Park
    Department of Laboratory Medicine, Ajou University Hospital, San 5, Wonchun Dong, Yeongtong Gu, Suwon, South Korea
    J Clin Microbiol 45:3903-8. 2007
    ..The tendency for the rearrangement of Tn1546 was that the sequences were shortened as time passed, especially at the left or the right end, and hence, this could gradually modulate their transferability...
  94. pmc Comparison of the BD GeneOhm VanR assay to culture for identification of vancomycin-resistant enterococci in rectal and stool specimens
    Paul D Stamper
    Department of Pathology, The Johns Hopkins University, Baltimore, MD 21287, USA
    J Clin Microbiol 45:3360-5. 2007
    ..However, patient samples testing only vanB positive should be confirmed by another method for the presence of VRE...
  95. ncbi Vancomycin-resistant enterococci in a Chinese hospital
    S Li
    Department of Clinical Laboratory Medicine, People s Hospital of Peking University, No 11 Xizhimen South Street, Xicheng District, Beijing 100044, China
    Curr Microbiol 55:125-7. 2007
    ..This is the first study that sequenced van genes of VRE isolates in China to date and found type VanB in China. Because of the relatively low isolating rate, early detection of VRE is vital...
  96. ncbi Effect of banning vancomycin analogue avoparcin on vancomycin-resistant enterococci in chicken farms in Taiwan
    Tsai Ling Lauderdale
    Division of Clinical Research, National Health Research Institutes, Zhunan, Taiwan
    Environ Microbiol 9:819-23. 2007
    ....
  97. ncbi Comparison of the VITEK 2 system with the E-test for the determination of glycopeptide susceptibility of vanA and vanC positive enterococci
    Zsuzsanna Dombrádi
    Debrecen University, Institute of Medical Microbiology, Medical and Health Science Center, Debrecen, Hungary
    Acta Microbiol Immunol Hung 57:157-63. 2010
    ..Therefore, at laboratories using automated systems (e.g. VITEK 2) for routine microbiological susceptibility testing data must be confirmed by independent validated methods, e.g. E-test, or microdilution...
  98. pmc In vivo transfer of the vanA resistance gene from an Enterococcus faecium isolate of animal origin to an E. faecium isolate of human origin in the intestines of human volunteers
    Camilla H Lester
    National Center for Antimicrobials and Infection Control, Statens Serum Institut, 5 Artillerivej, DK 2300 Copenhagen S, Denmark
    Antimicrob Agents Chemother 50:596-9. 2006
    ..g., immunocompromised patients...
  99. ncbi Epidemiological study of vancomycin-resistant enterococcus isolated from a single medical university hospital in Japan
    K Ishikawa
    Department of Urology, Fujita Health University, 1 98 Dengakugakubo, Kutsukake cho, Toyoake, Aichi 470 1192, Japan
    J Infect Chemother 7:163-8. 2001
    ..In this study, we demonstrated that infection control, according to appropriate prevention guidelines, as well as regular surveillance for VRE, are essential for designing interventions to prevent the further spread of VRE...
  100. ncbi Separate insertion and deletion subcomplexes of the Trypanosoma brucei RNA editing complex
    Achim Schnaufer
    Seattle Biomedical Research Institute, 4 Nickerson Street, Suite 200, Seattle, WA 98109, USA
    Mol Cell 12:307-19. 2003
    ..This study provides insight into the molecular architecture of the editosome and supports the existence of separate subcomplexes for deletion and insertion editing...
  101. pmc Heterologous expression of the enterococcal vanA operon in methicillin-resistant Staphylococcus aureus
    Bruno Perichon
    Unite des Agents Antibacteriens, Institut Pasteur, 25, rue du Docteur Roux, 75724 Paris Cedex 15, France
    Antimicrob Agents Chemother 48:4281-5. 2004
    ..aureus PA-VRSA is thus likely due to instability of the genetic element, plasmid or transposon, carrying the vanA operon associated with a longer lag phase before growth resumes after induction by vancomycin...

Research Grants5

  1. HUMAN RETROVIRUS-5 AND ARTHRITIS
    Robin Patel; Fiscal Year: 2002
    ..Identification of a specific infectious agent associated with these arthritides would potentially allo for the development of preventive strategies such as vaccination and novel therapeutic approaches. ..
  2. Enhancement of antimicrobics by electrical current
    Robin Patel; Fiscal Year: 2007
    ..This novel but simple resistance reversing strategy may generalize to a wide variety of antimicrobics and microorganisms and a wide variety of biofilm-associated human infections. [unreadable] [unreadable] [unreadable] [unreadable]..
  3. Detection of Biofilm Bacteria using GloBac
    Robin Patel; Fiscal Year: 2008
    ..The goal of the proposed studies is to develop a rapid test for detection of bacteria on artificial joints that can be used in the operating room to diagnose infected artificial joints. [unreadable] [unreadable] [unreadable]..
  4. The SMD-Relaxed Complex Method for Drug Design
    Rommie Amaro; Fiscal Year: 2008
    ..The success of this new approach will be demonstrated on an essential RNA editing enzyme found in the trypanosomatid pathogens, which are responsible for several devastating tropical diseases. [unreadable] [unreadable] [unreadable]..
  5. INVASION AND ADHESION OF PERIOPATHOGENS
    Keith Mintz; Fiscal Year: 2007
    ..actinomycetemcomitans. The identification of these components will be important in understanding the processes that this pathogen uses to survive in the oral cavity and disperse into deeper tissues. ..