mannose 6 phosphate isomerase

Summary

Summary: An enzyme that catalyzes the reversible isomerization of D-mannose-6-phosphate to form D-fructose-6-phosphate, an important step in glycolysis. EC 5.3.1.8.

Top Publications

  1. ncbi Genomic organization of the human phosphomannose isomerase (MPI) gene and mutation analysis in patients with congenital disorders of glycosylation type Ib (CDG-Ib)
    E Schollen
    Center for Human Genetics, University of Leuven, Leuven, Belgium
    Hum Mutat 16:247-52. 2000
  2. ncbi [Molecular diagnosis of congenital disorders of glycosylation]
    S Vuillaumier-Barrot
    Laboratoire de Biochimie A, Hôpital Bichat AP HP, Paris, France
    Ann Biol Clin (Paris) 63:135-43. 2005
  3. ncbi Effective selection of transgenic papaya plants with the PMI/Man selection system
    Yun J Zhu
    Hawaii Agriculture Research Center, 99 193 Aiea Heights Drive, Aiea, HI 96701, USA
    Plant Cell Rep 24:426-32. 2005
  4. ncbi The use of the phosphomannose-isomerase/mannose selection system to recover transgenic apple plants
    Juliana Degenhardt
    Institute of Biological Production Systems, Fruit Science Section, University of Hannover, Herrenhaeuser Str 2, 30419, Hannover, Germany
    Plant Cell Rep 25:1149-56. 2006
  5. ncbi Carbohydrate-deficient glycoprotein syndrome 1b: a new answer to an old diagnostic dilemma
    D F Kelly
    Department of Gastroenterology, Royal Children's Hospital, Parkville, Victoria, Australia
    J Paediatr Child Health 37:510-2. 2001
  6. pmc Synthesis of L-ascorbic acid in the phloem
    Robert D Hancock
    Unit of Plant Biochemistry, Scottish Crop Research Institute, Invergowrie, Dundee DD2 5DA, United Kingdom
    BMC Plant Biol 3:7. 2003
  7. ncbi Differential patterns of spatial divergence in microsatellite and allozyme alleles: further evidence for locus-specific selection in the acorn barnacle, Semibalanus balanoides?
    F Dufresne
    Departement de Biologie, Universite Laval, Cite Universitaire, Sainte Foy, Canada
    Mol Ecol 11:113-23. 2002
  8. ncbi Bifunctional phosphoglucose/phosphomannose isomerases from the Archaea Aeropyrum pernix and Thermoplasma acidophilum constitute a novel enzyme family within the phosphoglucose isomerase superfamily
    Thomas Hansen
    Institut fur Allgemeine Mikrobiologie, Christian Albrechts Universitat Kiel, Am Botanischen Garten 1 9, D 24118 Kiel, Germany
    J Biol Chem 279:2262-72. 2004
  9. pmc Golden Indica and Japonica rice lines amenable to deregulation
    Tran Thi Cuc Hoa
    Institute for Plant Sciences, Swiss Federal Institute of Technology, CH 8092 Zurich, Switzerland
    Plant Physiol 133:161-9. 2003
  10. ncbi Komrower Lecture. Congenital disorders of glycosylation (CDG): it's all in it!
    J Jaeken
    Department of Pediatrics, Centre for Metabolic Disease, University Hospital Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    J Inherit Metab Dis 26:99-118. 2003

Research Grants

Scientific Experts

Detail Information

Publications120 found, 100 shown here

  1. ncbi Genomic organization of the human phosphomannose isomerase (MPI) gene and mutation analysis in patients with congenital disorders of glycosylation type Ib (CDG-Ib)
    E Schollen
    Center for Human Genetics, University of Leuven, Leuven, Belgium
    Hum Mutat 16:247-52. 2000
    ..In the last, the mutation resulted in an unstable transcript, and was hardly detectable at the mRNA level. This emphasizes the importance of mutation analysis at the genomic DNA level...
  2. ncbi [Molecular diagnosis of congenital disorders of glycosylation]
    S Vuillaumier-Barrot
    Laboratoire de Biochimie A, Hôpital Bichat AP HP, Paris, France
    Ann Biol Clin (Paris) 63:135-43. 2005
    ..We report novel mutations and their functional study. In addition we looked for a founder effect for the most frequent mutations observed in the French population...
  3. ncbi Effective selection of transgenic papaya plants with the PMI/Man selection system
    Yun J Zhu
    Hawaii Agriculture Research Center, 99 193 Aiea Heights Drive, Aiea, HI 96701, USA
    Plant Cell Rep 24:426-32. 2005
    ..Additionally, since the PMI/Man selection system does not involve antibiotic or herbicide resistance genes, its use might reduce environmental concerns about the potential flow of those genes into related plant populations...
  4. ncbi The use of the phosphomannose-isomerase/mannose selection system to recover transgenic apple plants
    Juliana Degenhardt
    Institute of Biological Production Systems, Fruit Science Section, University of Hannover, Herrenhaeuser Str 2, 30419, Hannover, Germany
    Plant Cell Rep 25:1149-56. 2006
    ..The pmi/mannose selection system is shown to be highly efficient for producing transgenic apple plants without using antibiotics or herbicides...
  5. ncbi Carbohydrate-deficient glycoprotein syndrome 1b: a new answer to an old diagnostic dilemma
    D F Kelly
    Department of Gastroenterology, Royal Children's Hospital, Parkville, Victoria, Australia
    J Paediatr Child Health 37:510-2. 2001
    ..CDGS1b was suspected, supported by the finding of a protein-losing enteropathy and finally confirmed by showing a reduced phosphomannoseisomerase activity. This case illustrates a rare condition with a wide range of presentations...
  6. pmc Synthesis of L-ascorbic acid in the phloem
    Robert D Hancock
    Unit of Plant Biochemistry, Scottish Crop Research Institute, Invergowrie, Dundee DD2 5DA, United Kingdom
    BMC Plant Biol 3:7. 2003
    ..Possible sources of AsA in plant storage organs include in situ synthesis and long-distance transport of AsA synthesised in other tissues via the phloem. In this paper we examine a third possibility, that of synthesis within the phloem...
  7. ncbi Differential patterns of spatial divergence in microsatellite and allozyme alleles: further evidence for locus-specific selection in the acorn barnacle, Semibalanus balanoides?
    F Dufresne
    Departement de Biologie, Universite Laval, Cite Universitaire, Sainte Foy, Canada
    Mol Ecol 11:113-23. 2002
    ..They also indicated that microsatellites may not always behave in a neutral way and must be used cautiously, especially when evidence for genetic structuring relies on only a few assayed loci...
  8. ncbi Bifunctional phosphoglucose/phosphomannose isomerases from the Archaea Aeropyrum pernix and Thermoplasma acidophilum constitute a novel enzyme family within the phosphoglucose isomerase superfamily
    Thomas Hansen
    Institut fur Allgemeine Mikrobiologie, Christian Albrechts Universitat Kiel, Am Botanischen Garten 1 9, D 24118 Kiel, Germany
    J Biol Chem 279:2262-72. 2004
    ..Thus, we propose that bifunctional PGI/PMI constitutes a novel protein family within the PGI superfamily...
  9. pmc Golden Indica and Japonica rice lines amenable to deregulation
    Tran Thi Cuc Hoa
    Institute for Plant Sciences, Swiss Federal Institute of Technology, CH 8092 Zurich, Switzerland
    Plant Physiol 133:161-9. 2003
    ....
  10. ncbi Komrower Lecture. Congenital disorders of glycosylation (CDG): it's all in it!
    J Jaeken
    Department of Pediatrics, Centre for Metabolic Disease, University Hospital Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    J Inherit Metab Dis 26:99-118. 2003
    ..The latter group promises to become an important new chapter in CDG. It is concluded that CDGs will eventually cover the whole clinical spectrum of paediatric and adult disease manifestations...
  11. ncbi Prospecting the utility of a PMI/mannose selection system for the recovery of transgenic sugarcane (Saccharum spp. hybrid) plants
    Mukesh Jain
    Department of Agronomy, Genetics Institute, University of Florida, Gainesville, FL 32611 0300, USA
    Plant Cell Rep 26:581-90. 2007
    ..Expression of manA in the transgenic plants was evaluated using a chlorophenol red assay and enzymatic analysis...
  12. ncbi Evaluation of selection strategies alternative to nptII in genetic transformation of citrus
    Alida Ballester
    Centre of Plant Protection and Biotechnology, Instituto Valenciano de Investigaciones Agrarias IVIA, Apartado Oficial, 46113 Moncada, Valencia, Spain
    Plant Cell Rep 27:1005-15. 2008
    ..Thirdly, the highest transformation rates were obtained with the PMI/mannose system, 30% for citrange and 13% for sweet orange, which indicates that this marker is also an excellent candidate for citrus transformation...
  13. ncbi Protective effects of allozyme genotype during chemical exposure in the grass shrimp, Palaemonetes pugio
    Ruth M Harper-Arabie
    Environmental Science and Engineering Division, Colorado School of Mines, Golden, CO, USA
    Aquat Toxicol 70:41-54. 2004
    ..Although a relationship between Gpi genotype and contaminant tolerance has been identified in previous studies, no such relationship has been documented in P. pugio or with chromium(VI) as the contaminant...
  14. pmc PMI40, an intron-containing gene required for early steps in yeast mannosylation
    D J Smith
    Glaxo Institute for Molecular Biology, Plan les Ouates, Geneva, Switzerland
    Mol Cell Biol 12:2924-30. 1992
    ..PMI enzyme activity, however, is not increased in D-mannose-grown cells, and PMI protein levels remain constant, suggesting that the PMI40 gene is subject to additional levels of regulation...
  15. ncbi Regional variation in the spatial scale of selection at MPI* and GPI* in the acorn barnacle Semibalanus balanoides (Crustacea)
    D Veliz
    Departement de Biologie, Québec Océan, Universite Laval, Quebec, Canada
    J Evol Biol 17:953-66. 2004
    ..Comparisons between this study and previous ones also question the generality of current hypotheses regarding ecological processes that are responsible for maintaining polymorphism at MPI* and GPI* in the acorn barnacle...
  16. ncbi Bifunctional phosphoglucose/phosphomannose isomerase from the hyperthermophilic archaeon Pyrobaculum aerophilum
    Thomas Hansen
    Institut fur Allgemeine Mikrobiologie, Christian Albrechts Universitat Kiel, Am Botanischen Garten 1 9, 24118 Kiel, Germany
    Extremophiles 8:507-12. 2004
    ..The enzyme was extremely thermoactive; it had a temperature optimum for catalytic activity of about 100 degrees C and a melting temperature for thermal unfolding above 100 degrees C...
  17. ncbi The relative contribution of mannose salvage pathways to glycosylation in PMI-deficient mouse embryonic fibroblast cells
    Naonobu Fujita
    Department of Applied Biological Science, Tokyo University of Agriculture and Technology, Japan
    FEBS J 275:788-98. 2008
    ..From these data, we conclude that PMI-null cells can salvage mannose from both endogenous and external glycoconjugates via lysosomal and nonlysosomal degradation pathways...
  18. ncbi A novel phosphoglucose isomerase (PGI)/phosphomannose isomerase from the crenarchaeon Pyrobaculum aerophilum is a member of the PGI superfamily: structural evidence at 1.16-A resolution
    Michael K Swan
    Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Biol Chem 279:39838-45. 2004
    ..Instead, PMI activity may be the result of additional space in the active site imparted by a threonine, in place of a glutamine in other PGI enzymes, which could permit rotation of the C-2-C-3 bond of mannose 6-phosphate...
  19. ncbi Incomplete cryptic speciation between intertidal and subtidal morphs of Acrocnida brachiata (Echinodermata: Ophiuroidea) in the Northeast Atlantic
    D Muths
    Ecologie Benthique, UMR7144, CNRS UPMC, B P 74, 29682 Roscoff, France
    Mol Ecol 15:3303-18. 2006
    ..As previously suspected for a species with a very short pelagic larval phase, contemporary gene flow between distant or adjacent populations appears to be extremely reduced or even absent...
  20. ncbi Direct utilization of mannose for mammalian glycoprotein biosynthesis
    G Alton
    The Burnham Institute, La Jolla, CA 92037, USA
    Glycobiology 8:285-95. 1998
    ..Extracellular mannose may also make a significant contribution to glycoprotein biosynthesis in the intact organism...
  21. ncbi Identification of lipopolysaccharide O antigen synthesis genes required for attachment of the S-layer of Caulobacter crescentus
    P Awram
    Department of Microbiology and Immunology, University of British Columbia, 300 6174 University Blvd, Vancouver B C, CanadaV6T 1Z3
    Microbiology 147:1451-60. 2001
    ..Overall, the data are consistent with the hypothesis that the O antigen of C. crescentus S-LPS consists primarily of N-acetylperosamine residues polymerized with multiple anomeric linkages...
  22. pmc Identification and characterization of the dTDP-rhamnose biosynthesis and transfer genes of the lipopolysaccharide-related rfb locus in Leptospira interrogans serovar Copenhageni
    M Mitchison
    Department of Microbiology, Monash University, Clayton, Victoria, Australia
    J Bacteriol 179:1262-7. 1997
    ..Moreover, it could restore normal LPS phenotype to a defined rfbB::Tn5 mutant of S. flexneri which was deficient in all four genes, thereby confirming the functional identification of a part of the leptospiral rfb locus...
  23. ncbi Evolutionary diversity in polystomatids infecting tetraploid and octoploid Xenopus in East African highlands: biological and molecular evidence
    J A Jackson
    School of Biology, University of Nottingham, Nottingham NG7 2RD, UK
    Parasitology 134:1223-35. 2007
    ..The consequences of splitting P. simplicis for a recent interpretation of the origin of Protopolystoma faunas in octoploid Xenopus spp. is discussed...
  24. ncbi Structures of mannose-6-phosphate isomerase from Salmonella typhimurium bound to metal atoms and substrate: implications for catalytic mechanism
    S R Sagurthi
    Molecular Biophysics Unit, Indian Institute of Science, Bangalore 560 012, India
    Acta Crystallogr D Biol Crystallogr 65:724-32. 2009
    ..The metal atom appears to play a role in substrate binding and is probably also important for maintaining the architecture of the active site. Isomerization probably follows the previously suggested cis-enediol mechanism...
  25. ncbi Screening for CDG type Ia in Joubert syndrome
    Eva Morava
    Department of Pediatrics, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Med Sci Monit 10:CR469-72. 2004
    ..It has been postulated that some Joubert syndrome patients might have an underlying disorder of protein glycosylation...
  26. ncbi Gastrointestinal and other clinical manifestations in 17 children with congenital disorders of glycosylation type Ia, Ib, and Ic
    Gerard Damen
    Department of Pediatric Gastroenterology, Erasmus MC Sophia Children Hospital, Rotterdam, The Netherlands
    J Pediatr Gastroenterol Nutr 38:282-7. 2004
    ..However, more and more children diagnosed at a young age are not dysmorphic and do not have neurologic involvement. The authors studied the gastrointestinal and other clinical manifestations of CDG type Ia, Ib, and Ic...
  27. ncbi Genetic heterogeneity among intertidal habitats in the flat periwinkle, Littorina obtusata
    Paul S Schmidt
    Department of Biology, University of Pennsylvania, 433 S University Avenue, Philadelphia, PA 19104 6018, USA
    Mol Ecol 16:2393-404. 2007
    ....
  28. ncbi D-mannose transport and metabolism in isolated enterocytes
    Juan M Duran
    Dept Fisiologia y Biologia Animal, Facultad de Farmacia, Universidad de Sevilla, 41012 Seville, Spain
    Glycobiology 14:495-500. 2004
    ....
  29. ncbi The use of the phosphomannose isomerase gene as alternative selectable marker for Agrobacterium-mediated transformation of flax (Linum usitatissimum)
    Frédéric Lamblin
    Laboratoire de Biologie des Ligneux et des Grandes Cultures, UPRES EA 1207, Antenne Scientifique Universitaire de Chartres, Chartres, France
    Plant Cell Rep 26:765-72. 2007
    ..These results indicate that the PMI/mannose selection system can be successfully used for the recovery of flax transgenic plants under safe conditions for human health and the environment...
  30. ncbi Inhibition of type I and type II phosphomannose isomerases by the reaction intermediate analogue 5-phospho-D-arabinonohydroxamic acid supports a catalytic role for the metal cofactor
    Celine Roux
    Laboratoire de Chimie Bioorganique et Bioinorganique, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 8124, Institut de Chimie Moleculaire et des Materiaux d Orsay, Batiment 420, Universite Paris Sud XI, 91405 Orsay, France
    Biochemistry 43:2926-34. 2004
    ..All together, our results are consistent with a catalytic role for the metal cofactor in PMI activity...
  31. ncbi Pearl millet transformation system using the positive selectable marker gene phosphomannose isomerase
    M M O'Kennedy
    CSIR Food, Biological and Chemical Technologies, P O Box 395, 0001, Pretoria, South Africa
    Plant Cell Rep 22:684-90. 2004
    ....
  32. ncbi One-pot enzymatic production of dTDP-4-keto-6-deoxy-D-glucose from dTMP and glucose-1-phosphate
    Jongmin Oh
    Institute of Molecular Biology and Genetics and School of Chemical Engineering, Seoul National University, Seoul 151 742, South Korea
    Biotechnol Bioeng 84:452-8. 2003
    ..Using the reaction scheme, about 1 gram of purified dTDP-4-keto-6-deoxy-D-glucose was obtained in an overall yield of 81% after two-step purification, i.e., anion exchange chromatography and gel filtration...
  33. pmc The effects of diet and physiological stress on the evolutionary dynamics of an enzyme polymorphism
    P S Schmidt
    Department of Ecology and Evolutionary Biology, Brown University, Providence, RI 02912, USA
    Proc Biol Sci 268:9-14. 2001
    ..The widespread polymorphism at Mpi observed in marine taxa may reflect the interaction between dietary composition and environmental heterogeneity in intertidal habitats...
  34. pmc Mannose metabolism is required for mycobacterial growth
    John H Patterson
    Department of Biochemistry and Molecular Biology, University of Melbourne, Parkville, Victoria 3010, Australia
    Biochem J 372:77-86. 2003
    ..These results show that mannose metabolism is required for growth of M. smegmatis and that one or more mannose-containing molecules may play a role in regulating septation and cell division in these bacteria...
  35. pmc Polyphyly and gene flow between non-sibling Heliconius species
    Vanessa Bull
    Galton Laboratory, Department of Biology, University College London, 4 Stephenson Way, London NW1 2HE, UK
    BMC Biol 4:11. 2006
    ..melpomene (Lepidoptera: Nymphalidae), whose distributions overlap in Central and Northwestern South America...
  36. pmc Position-based scanning for comparative genomics and identification of genetic islands in Haemophilus influenzae type b
    Nicholas H Bergman
    Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan 48109 0620, USA
    Infect Immun 71:1098-108. 2003
    ....
  37. ncbi An efficient approach for cloning the dNDP-glucose synthase gene from actinomycetes and its application in Streptomyces spectabilis, a spectinomycin producer
    C Hyun
    Department of Biological Science, Institute of Bioscience and Biotechnology, Myong Ji University, Yongin, South Korea
    FEMS Microbiol Lett 183:183-9. 2000
    ..The spcE gene was expressed in Escherichia coli and the activity was assayed in cell extracts. The enzyme showed substrate specificity only to dTDP-glucose...
  38. ncbi Cloning and characterization of phosphomannose isomerase from Sphingomonas chungbukensis DJ77
    Sinh Thi Tran
    Deparment of Biochemistry, Chungbuk National University, Cheongju 361 763, Korea
    BMB Rep 42:523-8. 2009
    ..Of these ions, Co(2+) was found to be the most effective activator of PMI. GDP-D-mannose was found to inhibit the PMI activity, suggesting feedback regulation of this pathway...
  39. pmc Identification of a species-specific inhibitor of glycosylphosphatidylinositol synthesis
    C Sutterlin
    Biozentrum of the University of Basel, Switzerland
    EMBO J 16:6374-83. 1997
    ..These results suggest that despite the conserved core structure, the GPI biosynthetic machinery may be different enough between mammalian and protozoa to represent a target for anti-protozoan chemotherapy...
  40. pmc Deletion of algK in mucoid Pseudomonas aeruginosa blocks alginate polymer formation and results in uronic acid secretion
    S Jain
    Department of Microbiology and Immunology, University of Tennessee and Veterans Affairs Medical Center, Memphis 38163, USA
    J Bacteriol 180:634-41. 1998
    ..Thus, the alginate pathway in an AlgK- mutant was blocked after transport but at a step before polymerization, suggesting that AlgK plays an important role in the polymerization of mannuronate to alginate...
  41. ncbi Characterization of a mannose-6-phosphate isomerase from Geobacillus thermodenitrificans that converts monosaccharides
    Soo Jin Yeom
    Department of Bioscience and Biotechnology, Konkuk University, 1 Hwayang dong, Gwangjin gu, Seoul, 143 701, South Korea
    Biotechnol Lett 31:1273-8. 2009
    ..GTMpi catalyzed the conversion of D-lyxose to D-xylulose with a 38% conversion yield after 3 h, and converted L-ribose to L-ribulose with a 29% conversion yield...
  42. pmc The identification of cryptic rhamnose biosynthesis genes in Neisseria gonorrhoeae and their relationship to lipopolysaccharide biosynthesis
    B D Robertson
    Max Planck Institut fur Biologie, Abteilung Infektionsbiologie, Tubingen, Germany
    J Bacteriol 176:6915-20. 1994
    ..gonorrhoeae either because of the presence of the galE gene or because of another as yet unrecognized function...
  43. pmc Structure of the O antigen of Escherichia coli K-12 and the sequence of its rfb gene cluster
    G Stevenson
    Department of Microbiology, University of Sydney, New South Wales, Australia
    J Bacteriol 176:4144-56. 1994
    ..We suggest that the K-12 gene cluster is a member of a family of rfb gene clusters, including those of Dysenteriae 1 and Flexneri, which evolved outside E. coli and was acquired by lateral gene transfer...
  44. ncbi Ontogeny of D-mannose transport and metabolism in rat small intestine
    Mecedes Cano
    Departamento de Fisiologia y Zoologia, Universidad de Sevilla, Spain
    J Membr Biol 235:101-8. 2010
    ..In conclusion, intestinal D-mannose transport activity and metabolism were affected by ontogeny and intestinal segment...
  45. pmc N-glycosylation augmentation of the cystic fibrosis epithelium improves Pseudomonas aeruginosa clearance
    Ashley T Martino
    Department of Molecular Genetics and Microbiology, College of Medicine, University of Florida, Gainesville, Florida, USA
    Am J Respir Cell Mol Biol 44:824-30. 2011
    ..Augmenting N-glycosylation to attenuate colonization of P. aeruginosa in CF airways reveals a new therapeutic avenue for a hallmark disease condition in CF...
  46. ncbi Phosphomannose isomerase/GDP-mannose pyrophosphorylase from Pyrococcus furiosus: a thermostable biocatalyst for the synthesis of guanidinediphosphate-activated and mannose-containing sugar nucleotides
    Rahman M Mizanur
    Department of Chemistry and Plant Sciences Institute, Gilman Hall, Iowa State University, Ames, Iowa 50011 3111, USA
    Org Biomol Chem 7:2135-9. 2009
    ....
  47. pmc Carbohydrate-deficient glycoprotein syndrome type V: deficiency of dolichyl-P-Glc:Man9GlcNAc2-PP-dolichyl glucosyltransferase
    C Korner
    Georg August Universitat Gottingen, Abt Biochemie II, Gosslerstr 12d, D 37073 Gottingen, Germany
    Proc Natl Acad Sci U S A 95:13200-5. 1998
    ..This finding is reflected in the presence of transferrin forms in serum that lack one or both of the two N-linked oligosaccharides and the reduction of mannose incorporation to about one-third of control in glycoproteins of fibroblasts...
  48. ncbi Molecular basis of carbohydrate-deficient glycoprotein syndromes type I with normal phosphomannomutase activity
    H H Freeze
    The Burnham Institute, La Jolla, CA 92037, USA
    Biochim Biophys Acta 1455:167-78. 1999
    ..Yeast strains carrying mutations in the homologous genes are likely to provide conclusive identification of the primary defects in novel CDGS types that affect the synthesis and transfer of precursor oligosaccharides...
  49. ncbi Antifungal activity of Ag(I) and Zn(II) complexes of aminobenzolamide (5-sulfanilylamido-1,3,4-thiadiazole-2-sulfonamide) derivatives
    A Mastrolorenzo
    Universita degli Studi, Dipartimento di Scienze Dermatologiche, Centro MTS, Firenze, Italia
    J Enzyme Inhib 15:517-31. 2000
    ..Probably the new complexes act as inhibitors of phosphomannose isomerase, a key enzyme in the biosynthesis of yeast cell walls...
  50. pmc Development of novel sugar isomerases by optimization of active sites in phosphosugar isomerases for monosaccharides
    Soo Jin Yeom
    Department of Bioscience and Biotechnology, Konkuk University, Seoul, Republic of Korea
    Appl Environ Microbiol 79:982-8. 2013
    ..In this study, we used substrate-tailored optimization to develop novel sugar isomerases which are not found in nature based on phosphosugar isomerases...
  51. ncbi The Azospirillum brasilense Sp7 noeJ and noeL genes are involved in extracellular polysaccharide biosynthesis
    Anat Lerner
    Department of Plant Pathology and Microbiology and The Otto Warburg Minerva Center for Agricultural Biotechnology, The Robert H Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, PO Box 12, Rehovot 76100, Israel
    Microbiology 155:4058-68. 2009
    ..brasilense Sp7 to form biofilms. The pleiotropic alterations observed in the mutants could be due, at least partially, to their altered lipopolysaccharides and exopolysaccharides relative to the wild-type...
  52. ncbi Sequence of the phosphomannose isomerase-encoding gene of Salmonella typhimurium
    L V Collins
    Department of Microbiology and Immunology, University of Adelaide, South Australia
    Gene 103:135-6. 1991
    ..The cloned gene was sequenced; there was 77.4% nucleotide homology between the cloned pmi gene and the analogous manA gene of E. coli K-12, and 86.2% amino acid sequence homology between their presumptive gene products...
  53. ncbi Haemophilus ducreyi produces a novel sialyltransferase. Identification of the sialyltransferase gene and construction of mutants deficient in the production of the sialic acid-containing glycoform of the lipooligosaccharide
    J A Bozue
    Children s Hospital Research Foundation, Ohio State University, Columbus, Ohio 43205 2696, USA
    J Biol Chem 274:4106-14. 1999
    ..We conclude that the lst gene encodes the H. ducreyi sialyltransferase. Since the lst gene product has little, if any, structural relationship to other sialyltransferases, this protein represents a new class of sialyltransferase...
  54. pmc Biological function of the dTDP-rhamnose synthesis pathway in Streptococcus mutans
    Y Tsukioka
    Department of Preventive Dentistry, Kyushu University Faculty of Dentistry, Fukuoka, Japan
    J Bacteriol 179:1126-34. 1997
    ..This is the first report of the biological function of the dTDP-rhamnose pathway in streptococci...
  55. ncbi Comparison of ascorbic acid biosynthesis in different tissues of three non-heading Chinese cabbage cultivars
    Jun Ren
    Horticultural Department, Nanjing Agricultural University, Nanjing 210095, China State Key Laboratory of Crop Genetics and Germplasm Enhancement, Nanjing 210095, China Key Laboratory of Southern Vegetable Crop Genetic Improvement, Ministry of Agriculture, Nanjing 210095, China
    Plant Physiol Biochem 73:229-36. 2013
    ..Therefore, the high expression levels of PMI, GME, and GGP and the low expression level of AAO contributed to the high AsA accumulation in non-heading Chinese cabbage...
  56. ncbi Metabolic engineering of Corynebacterium glutamicum to produce GDP-L-fucose from glucose and mannose
    Young Wook Chin
    Department of Agricultural Biotechnology, Center for Food and Bioconvergence, Seoul National University, Seoul, 151 921, Republic of Korea
    Bioprocess Biosyst Eng 36:749-56. 2013
    ..Well-established metabolic engineering tools may permit optimization of the carbon and cofactor metabolisms of C. glutamicum to further improve their production capacity...
  57. pmc Complete nucleotide sequence of the fumarase gene fumA, of Escherichia coli
    J S Miles
    Nucleic Acids Res 12:3631-42. 1984
    ..The DNA fragment also contains the 5' end of the manA gene encoding mannose 6-phosphate isomerase, which is transcribed with the opposite polarity to fumA ...
  58. ncbi Development of a genetic assay to distinguish between Leishmania viannia species on the basis of isoenzyme differences
    Wen Wei Zhang
    Department of Microbiology and Immunology, McGill University, Montreal, Canada
    Clin Infect Dis 42:801-9. 2006
    ..However, because of the close genetic similarity of L. braziliensis and L. peruviana, there currently exists no simple assay to distinguish between these species...
  59. pmc DNA polymorphism analysis of Brucella lipopolysaccharide genes reveals marked differences in O-polysaccharide biosynthetic genes between smooth and rough Brucella species and novel species-specific markers
    Michel S Zygmunt
    INRA, UR1282, Infectiologie Animale et Sante Publique, IASP, Nouzilly, France
    BMC Microbiol 9:92. 2009
    ..In smooth brucellae, lipopolysaccharide is made of lipid A-core oligosaccharide and N-formylperosamine O-polysaccharide. B. ovis and B. canis (rough species) lack the O-polysaccharide...
  60. ncbi A putative pathway for perosamine biosynthesis is the first function encoded within the rfb region of Vibrio cholerae O1
    U H Stroeher
    Department of Microbiology and Immunology, University of Adelaide, Australia
    Gene 166:33-42. 1995
    ..This suggests very tight constraints on the micro-evolution within these sequences...
  61. pmc Characterization of a mannose-6-phosphate isomerase from Thermus thermophilus and increased L-ribose production by its R142N mutant
    Soo Jin Yeom
    Department of Bioscience and Biotechnology, Konkuk University, 1 Hwayang dong, Gwangjin gu, Seoul 143 701, Republic of Korea
    Appl Environ Microbiol 77:762-7. 2011
    ..The R142N mutant enzyme produced 213 g/liter L-ribose from 300 g/liter L-ribulose for 2 h, with a volumetric productivity of 107 g liter(-1) h(-1), which was 1.5-fold higher than that of the wild-type enzyme...
  62. ncbi Phosphomannose isomerase and phosphomannomutase gene disruptions in Streptomyces nodosus: impact on amphotericin biosynthesis and implications for glycosylation engineering
    Laura Nic Lochlainn
    School of Biomolecular and Biomedical Science and Centre for Synthesis and Chemical Biology, University College Dublin, Ardmore House, Belfield, Dublin 4, Ireland
    Metab Eng 11:40-7. 2009
    ..With further genetic engineering these mutants may activate alternative hexoses as GDP-sugars for transfer to aglycones in vivo...
  63. ncbi Identification of amino acid residues important for the phosphomannose isomerase activity of PslB in Pseudomonas aeruginosa PAO1
    Hui Ju Lee
    College of Biological Science and Technology, National Chiao Tung University, 75 Po Ai Street, Hsin Chu, Taiwan
    FEBS Lett 582:3479-83. 2008
    ..The PMI activity of PslB was completely diminished with a R408K or R408A, reflecting the importance of this residue in catalysis. Overall, these results provide a basis for understanding the catalytic mechanism of PMI...
  64. ncbi Typing of four genetic loci discriminates among closely related species of New World Leishmania
    Pablo Tsukayama
    Parasitology Program, Naval Medical Research Center Detachment, Lima, Peru
    Int J Parasitol 39:355-62. 2009
    ..braziliensis, this method ensures correct species identification, even when the agent is a genetic variant. Proper identification could facilitate adequate treatment, preventing the onset of the disfiguring mucosal form of the disease...
  65. ncbi In vivo performance of a dual genetic marker, manA-gfp, in transgenic bentgrass
    Daolin Fu
    Department of Agronomy, Kansas State University, Manhattan, 66506, USA
    Genome 48:722-30. 2005
    ..This study on the environmentally friendly markers further documented the feasibility of using alternative selection methods without using herbicide- or antibiotic-resistance markers...
  66. ncbi Escherichia coli phosphoglucose isomerase can be substituted by members of the PGI family, the PGI/PMI family, and the cPGI family
    Thomas Hansen
    Institut fur Allgemeine Mikrobiologie, Christian Albrechts Universitat Kiel, Am Botanischen Garten 1 9, D 24118 Kiel, Germany
    FEMS Microbiol Lett 250:49-53. 2005
    ..coli PGI. However, complete restoration of the growth rate could not be obtained by any of the PGIs, PGI/PMIs, or cPGIs used. The data indicate that the PGI function of the three PGI families is functionally exchangeable in glycolysis...
  67. pmc Arabidopsis phosphomannose isomerase 1, but not phosphomannose isomerase 2, is essential for ascorbic acid biosynthesis
    Takanori Maruta
    Department of Advanced Bioscience, Faculty of Agriculture, Kinki University, 3327 204 Nakamachi, Nara 631 8505, Japan
    J Biol Chem 283:28842-51. 2008
    ....
  68. ncbi Successful genetic transformation of Chinese cabbage using phosphomannose isomerase as a selection marker
    Byung Whan Min
    Department of Plant Resources, Sangju National University, Sangju, Gyeongbuk, Korea
    Plant Cell Rep 26:337-44. 2007
    ..The transformation method presented here for Chinese cabbage using mannose selection is efficient and reproducible, and it can be useful to introduce a desirable gene(s) into commercially useful inbred lines of Chinese cabbage...
  69. pmc Exogenous mannose does not raise steady state mannose-6-phosphate pools of normal or N-glycosylation-deficient human fibroblasts
    Aya Higashidani
    Department of Applied Biological Science, Tokyo University of Agriculture and Technology, Tokyo 183 8509, Japan
    Mol Genet Metab 96:268-72. 2009
    ..These results make it very unlikely that exogenous mannose could impair N-glycosylation in glycosylation-deficient CDG patients...
  70. ncbi Ablation of mouse phosphomannose isomerase (Mpi) causes mannose 6-phosphate accumulation, toxicity, and embryonic lethality
    Charles DeRossi
    Glycobiology and Carbohydrate Chemistry Program, Burnham Institute for Medical Research, 10901 N Torrey Pines Road, La Jolla, CA 92037, USA
    J Biol Chem 281:5916-27. 2006
    ..5 Mpi(-/-) embryos where Man-6-P increased more than 10 times, and ATP decreased by 50% compared with Mpi(+/+) littermates. Because Mpi ablation is embryonic lethal, a murine CDG-Ib model will require hypomorphic Mpi alleles...
  71. ncbi Development of a phosphomannose isomerase-based Agrobacterium-mediated transformation system for chickpea (Cicer arietinum L.)
    Gunvant Patil
    National Research Centre on Plant Biotechnology, New Delhi, India
    Plant Cell Rep 28:1669-76. 2009
    ..These positive results suggest that the pmi/mannose selection system can be used to produce transgenic plants of chickpea that are free from antibiotic resistance marker genes...
  72. ncbi Computational study of human phosphomannose isomerase: Insights from homology modeling and molecular dynamics simulation of enzyme bound substrate
    Jingfa Xiao
    Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
    J Mol Graph Model 25:289-95. 2006
    ..The detailed mechanism involves, on one side, Zn2+ mediating the movement of a proton between O1 and O2, and, on the other side, the hydrophobic environment formed in part by Tyr278 promoting transfer of a hydride ion...
  73. pmc Substrate specificity of a mannose-6-phosphate isomerase from Bacillus subtilis and its application in the production of L-ribose
    Soo Jin Yeom
    Department of Bioscience and Biotechnology, Konkuk University, 1 Hwayang dong, Gwangjin gu, Seoul 143 701, South Korea
    Appl Environ Microbiol 75:4705-10. 2009
    ....
  74. ncbi Elevation of plasma aspartylglucosaminidase is a useful marker for the congenital disorders of glycosylation type I (CDG I)
    M Jackson
    The Enzyme Laboratory, Great Ormond Street Hospital NHS Trust, London, UK
    J Inherit Metab Dis 28:1197-8. 2005
    ..The CDG I patients in whom the activity was not raised were either atypical clinically (CDG Ia) or very young (CDG Ih)...
  75. ncbi Preliminary studies on the inhibition of D-sorbitol-6-phosphate 2-dehydrogenase from Escherichia coli with substrate analogues
    Celine Roux
    Laboratoire de Chimie Bioorganique et Bioinorganique, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 8124, Institut de Chimie Moleculaire et des Materiaux d Orsay, Batiment 420, Universite Paris Sud XI, 91405 Orsay Cedex, France
    J Enzyme Inhib Med Chem 21:187-92. 2006
    ..coli D-sorbitol-6-phosphate 2-dehydrogenase yet reported with an IC50 = 7.5 +/- 0.4 microM and corresponding Km/IC50 ratio = about 76...
  76. ncbi Synthesis and evaluation of non-hydrolyzable D-mannose 6-phosphate surrogates reveal 6-deoxy-6-dicarboxymethyl-D-mannose as a new strong inhibitor of phosphomannose isomerases
    Johanna Foret
    Univ Paris Sud, Equipe de Chimie Bioorganique et Bioinorganique, ICMMO, UMR8182, Batiment 420, 15 rue Georges Clemenceau, Orsay F 91405, France
    Bioorg Med Chem 17:7100-7. 2009
    ..The kinetic study reported here also suggests the dianionic character of the phosphate surrogate as a likely essential parameter for strong binding of the inhibitor to the enzyme active site...
  77. ncbi Phosphomannose isomerase gene for selection in lettuce (Lactuca sativa L.) transformation
    Jindrich Bríza
    Biology Centre of the Academy of Sciences of the Czech Republic, v v i, Institute of Plant Molecular Biology, Ceske Budejovice, Czech Republic
    Acta Biochim Pol 57:63-8. 2010
    ..The results demonstrate that both mannose and kanamycin provide comparable transformation efficiencies in our lettuce genotype. An alternative selection method with mannose as a selection agent is now available for lettuce transgenosis...
  78. ncbi Agrobacterium and biolistic transformation of onion using non-antibiotic selection marker phosphomannose isomerase
    Chenna Reddy Aswath
    Indian Institute of Horticultural Research, Bangalore 560089, India
    Plant Cell Rep 25:92-9. 2006
    ..Integrative transformation was confirmed by PCR, RT-PCR and Southern hybridization...
  79. ncbi Overexpression of Mycobacterium tuberculosis manB, a phosphomannomutase that increases phosphatidylinositol mannoside biosynthesis in Mycobacterium smegmatis and mycobacterial association with human macrophages
    Travis R McCarthy
    Department of Medicine and Molecular Virology, The Center for Microbial Interface Biology, and the Division of Infectious Diseases, The Ohio State University, Columbus, OH 43210, USA
    Mol Microbiol 58:774-90. 2005
    ..We conclude that MtmanB encodes a functional PMM involved in the biosynthesis of mannosylated lipoglycans that participate in the association of mycobacteria with macrophage phagocytic receptors...
  80. ncbi Congenital disorders of glycosylation type Ia and Ib. Genetic, biochemical and clinical studies
    Susanne Kjaergaard
    Department of Clinical Genetics, H S Rigshospitalet, Copenhagen, Denmark
    Dan Med Bull 51:350-63. 2004
  81. ncbi Excess mannose limits the growth of phosphomannose isomerase PMI40 deletion strain of Saccharomyces cerevisiae
    Juha Pekka Pitkänen
    MediCel Ltd, Haartmaninkatu 8, FIN 00290 Helsinki, Finland
    J Biol Chem 279:55737-43. 2004
    ....
  82. ncbi Inhibition of phosphomannose isomerase by fructose 1-phosphate: an explanation for defective N-glycosylation in hereditary fructose intolerance
    J Jaeken
    Department of Pediatrics, University of Leuven, Belgium
    Pediatr Res 40:764-6. 1996
    ..3.1.8), the first enzyme of the N-glycosylation pathway thus explaining the N-glycosylation disturbances in HFI...
  83. pmc Carbohydrate-deficient glycoprotein syndrome type Ib. Phosphomannose isomerase deficiency and mannose therapy
    R Niehues
    Klinik und Poliklinik für Kinderheilkunde, 48149 Munster, Germany
    J Clin Invest 101:1414-20. 1998
    ..Daily oral mannose administration is a successful therapy for this new type of CDG syndrome classified as CDGS type Ib...
  84. pmc Phosphomannose isomerase deficiency: a carbohydrate-deficient glycoprotein syndrome with hepatic-intestinal presentation
    J Jaeken
    Am J Hum Genet 62:1535-9. 1998
  85. ncbi New gene assignments using a complete, characterized sheep-hamster somatic cell hybrid panel
    D J Burkin
    AgResearch, Department of Biochemistry, Dunedin, New Zealand
    Anim Genet 29:48-54. 1998
    ..Furthermore, the chromosomal assignment of 110 microsatellites was confirmed using this cell panel...
  86. ncbi Carbohydrate-deficient glycoprotein syndrome type IA (phosphomannomutase-deficiency)
    H Carchon
    Center for Metabolic Disease, O and N, University of Leuven, Belgium
    Biochim Biophys Acta 1455:155-65. 1999
    ..This review is an update on CDG syndrome type IA...
  87. ncbi Assignment of the structural genes for the alpha subunit of hexosaminidase A, mannosephosphate isomerase, and pyruvate kinase to the region q22-qter of human chromosome 15
    C J Chern
    Somatic Cell Genet 3:553-60. 1977
    ..A positive correlation was established between the expression of these human phenotypes and the presence of the distal half of the long arm of human chromosome 15...
  88. ncbi The role of phosphomannose isomerase in Leishmania mexicana glycoconjugate synthesis and virulence
    A Garami
    Max Planck Institut fur Biologie, Corrensstrasse 38, Tubingen 72076, Federal Republic of Germany
    J Biol Chem 276:6566-75. 2001
    ..L. mexicana Delta lmexpmi provides the first conditional mannose-controlled system for parasite glycoconjugate assembly with potential applications for the investigation of their biosynthesis, intracellular sorting, and function...
  89. ncbi Molecular evolution of the GDP-mannose pathway genes (manB and manC) in Salmonella enterica
    S O Jensen
    Department of Microbiology (G08, University of Sydney, New South Wales 2006, Australia
    Microbiology 147:599-610. 2001
    ..enterica and more closely related species...
  90. pmc Expression of the Escherichia coli pmi gene, encoding phosphomannose-isomerase in Zymomonas mobilis, leads to utilization of mannose as a novel growth substrate, which can be used as a selective marker
    P Weisser
    Institut für Biotechnologie 1, Forschungszentrum Julich GmbH, Germany
    Appl Environ Microbiol 62:4155-61. 1996
    ..34 h-1 on fructose for wild-type Z. mobilis. Selection for growth on mannose was used to monitor plasmid transfer of pZY507pmi from E. coli to Z. mobilis strains and could replace the previous selection for antibiotic resistance...
  91. pmc The Myxococcus xanthus rfbABC operon encodes an ATP-binding cassette transporter homolog required for O-antigen biosynthesis and multicellular development
    D Guo
    Department of Microbiology and Molecular Genetics, University of Texas Medical School, Houston 77030, USA
    J Bacteriol 178:1631-9. 1996
    ..These data indicate that the sasA locus is required for the biosynthesis of O-antigen and, when mutated, results in A-signal-independent expression of 4521...
  92. ncbi Comparison of isozyme patterns between Spirometra erinacei and Spirometra mansonoides by isoelectric focusing
    S Fukumoto
    Department of Medical Zoology, Faculty of Medicine, Tottori University, Yonago, Japan
    J Parasitol 78:735-8. 1992
    ..erinacei. These electrophoretic data suggest that the S. erinacei from Japan and Australia are closely related, if not identical, but that S. mansonoides is genetically distinct from S. erinacei...
  93. ncbi The Rhizobium meliloti pmi gene encodes a new type of phosphomannose isomerase
    M Schmidt
    Universitat Bielefeld, Lehrstuhl fur Genetik, Germany
    Gene 122:35-43. 1992
    ..The construction of a pmi-deficient mutant of R. meliloti using the sacB-sacR cassette technique showed that the loss of PMI activity does not affect the symbiotic properties of this strain...
  94. ncbi Purification and characterization of phosphomannose isomerase-guanosine diphospho-D-mannose pyrophosphorylase. A bifunctional enzyme in the alginate biosynthetic pathway of Pseudomonas aeruginosa
    D Shinabarger
    Department of Microbiology and Immunology, University of Illinois College of Medicine, Chicago 60612
    J Biol Chem 266:2080-8. 1991
    ..DNA sequencing of a cloned mutant algA gene from P. aeruginosa revealed that a point mutation at nucleotide 961 greatly decreased the levels of both PMI and GMP in a crude extract...
  95. pmc Enzymes of mannose metabolism in murine and human lymphocytic leukaemia
    M de la Fuente
    Department of Animal Biology II, Faculty of Biological Sciences, Complutense University, Madrid, Spain
    Br J Cancer 58:567-9. 1988
    ..The utility of analysing MPI activity in leukaemia patients and the use of mannose as an innocuous chemotherapic supporting agent in patients with decreased MPI activity is proposed...
  96. pmc Cloning, mapping, and expression of the fumarase gene of Escherichia coli K-12
    J R Guest
    J Bacteriol 153:588-96. 1983
    ..The basis for the complementation by fumB was not defined...
  97. ncbi Purification and characterization of fungal and mammalian phosphomannose isomerases
    A E Proudfoot
    Glaxo Institute for Molecular Biology, Geneva, Switzerland
    J Protein Chem 13:619-27. 1994
    ..albicans enzymes are almost identical. We suggest therefore that species-selective inhibition of the fungal rather than mammalian enzyme may require molecules which bind away from the substrate binding pocket of the enzyme...
  98. ncbi Cloning and heterologous expression of the Candida albicans gene PMI 1 encoding phosphomannose isomerase
    D J Smith
    Glaxo Institute for Molecular Biology, Geneva, Switzerland
    Yeast 11:301-10. 1995
    ..coli leads to partitioning of the enzyme between the soluble and particulate fractions. The protein produced in the soluble fraction is indistinguishable in kinetic properties from the material isolated from C. albicans cells...
  99. ncbi Arginine 304 is an active site residue in phosphomannose isomerase from Candida albicans
    T N Wells
    Glaxo Institute for Molecular Biology, Geneva, Switzerland
    Biochemistry 33:5777-82. 1994
    ..Radioactive counting of the phenylthiohydantoin amino acid derivatives confirmed that the modified amino acid was arginine 304. The role of this residue in the catalytic reaction of phosphomannose isomerase is discussed...
  100. ncbi Genetic and metabolic analysis of the first adult with congenital disorder of glycosylation type Ib: long-term outcome and effects of mannose supplementation
    V Westphal
    The Burnham Institute, 10901 N Torrey Pines Road, La Jolla, CA 92037, USA
    Mol Genet Metab 73:77-85. 2001
    ..However, the long-term prognosis may vary from patient to patient...
  101. ncbi Identification and characterization of the Cryptococcus neoformans phosphomannose isomerase-encoding gene, MAN1, and its impact on pathogenicity
    E A Wills
    University of Manchester, School of Biological Sciences, 1.800 Stopford Building, Manchester M13 9PT, UK
    Mol Microbiol 40:610-20. 2001
    ..neoformans in the host. The fact that the man1 mutant was not pathogenic suggests that blocking mannose synthesis could be fungicidal in the mammalian host and thus an excellent target for antifungal drug development...

Research Grants1

  1. A novel role for p53 in congenital disorders of glycosylation
    Jaime Chu; Fiscal Year: 2013
    ..I will then apply this knowledge to more common causes of these same diseases in pediatric patients, as non-alcoholic fatty liver disease, fibrosis, and cirrhosis are all associated with defects in protein glycosylation. ..