intramolecular oxidoreductases

Summary

Summary: Enzymes of the isomerase class that catalyze the oxidation of one part of a molecule with a corresponding reduction of another part of the same molecule. They include enzymes converting aldoses to ketoses (ALDOSE-KETOSE ISOMERASES), enzymes shifting a carbon-carbon double bond (CARBON-CARBON DOUBLE BOND ISOMERASES), and enzymes transposing S-S bonds (SULFUR-SULFUR BOND ISOMERASES). (From Enzyme Nomenclature, 1992) EC 5.3.

Top Publications

  1. ncbi Enzymes in jasmonate biosynthesis - structure, function, regulation
    Andreas Schaller
    Institute of Plant Physiology and Biotechnology, University of Hohenheim, D 70599 Stuttgart, Germany
    Phytochemistry 70:1532-8. 2009
  2. ncbi Tumor-derived macrophage migration inhibitory factor modulates the biology of head and neck cancer cells via neutrophil activation
    Claudia A Dumitru
    Department of Otorhinolaryngology, University of Duisburg Essen, Essen, Germany
    Int J Cancer 129:859-69. 2011
  3. pmc Identification of human prostaglandin E synthase: a microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target
    P J Jakobsson
    Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 96:7220-5. 1999
  4. ncbi Membrane prostaglandin E synthase-1: a novel therapeutic target
    Bengt Samuelsson
    Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 171 77, Stockholm, Sweden
    Pharmacol Rev 59:207-24. 2007
  5. ncbi Prostaglandin E2 synthesis and secretion: the role of PGE2 synthases
    Jean Y Park
    The Division of Rheumatology, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
    Clin Immunol 119:229-40. 2006
  6. pmc Tumor microenvironment macrophage inhibitory factor directs the accumulation of interleukin-17-producing tumor-infiltrating lymphocytes and predicts favorable survival in nasopharyngeal carcinoma patients
    Jiang Li
    State Key Laboratory of Oncology in South China
    J Biol Chem 287:35484-95. 2012
  7. ncbi Identification and characterization of a novel type of membrane-associated prostaglandin E synthase
    Naomi Tanikawa
    Special Division for Human Life Technology, Cell Dynamics Research Group, National Institute of AIST, Midorigaoka, Ikeda, Osaka 563 8577, Japan
    Biochem Biophys Res Commun 291:884-9. 2002
  8. ncbi Molecular identification of cytosolic prostaglandin E2 synthase that is functionally coupled with cyclooxygenase-1 in immediate prostaglandin E2 biosynthesis
    T Tanioka
    Department of Health Chemistry, School of Pharmaceutical Sciences, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142, Japan
    J Biol Chem 275:32775-82. 2000
  9. ncbi Role of macrophage migration inhibitory factor in primary glioblastoma multiforme cells
    Nina Baron
    Department of Neurology, Philipps University Marburg, Marburg, Germany
    J Neurosci Res 89:711-7. 2011
  10. pmc Cytochrome P450-dependent metabolism of oxylipins in tomato. Cloning and expression of allene oxide synthase and fatty acid hydroperoxide lyase
    G A Howe
    Department of Energy Plant Research Laboratory, Michigan State University, East Lansing 48824, USA
    Plant Physiol 123:711-24. 2000

Detail Information

Publications282 found, 100 shown here

  1. ncbi Enzymes in jasmonate biosynthesis - structure, function, regulation
    Andreas Schaller
    Institute of Plant Physiology and Biotechnology, University of Hohenheim, D 70599 Stuttgart, Germany
    Phytochemistry 70:1532-8. 2009
    ..Recent insights into the structure, function, and regulation of the enzymes involved in jasmonate biosynthesis help to explain how this variety is generated while specificity is maintained...
  2. ncbi Tumor-derived macrophage migration inhibitory factor modulates the biology of head and neck cancer cells via neutrophil activation
    Claudia A Dumitru
    Department of Otorhinolaryngology, University of Duisburg Essen, Essen, Germany
    Int J Cancer 129:859-69. 2011
    ..In conclusion, our data indicate that the effects of tumor-derived MIF on neutrophils represent an additional mechanism by which MIF might contribute to tumor progression...
  3. pmc Identification of human prostaglandin E synthase: a microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target
    P J Jakobsson
    Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 96:7220-5. 1999
    ..The enzyme activity is glutathione-dependent, and the protein expression is induced by the proinflammatory cytokine IL-1beta. PGE synthase is a potential novel target for drug development...
  4. ncbi Membrane prostaglandin E synthase-1: a novel therapeutic target
    Bengt Samuelsson
    Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 171 77, Stockholm, Sweden
    Pharmacol Rev 59:207-24. 2007
    ..These findings indicate that mPGES-1 is a potential target for the development of therapeutic agents for treatment of several diseases...
  5. ncbi Prostaglandin E2 synthesis and secretion: the role of PGE2 synthases
    Jean Y Park
    The Division of Rheumatology, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
    Clin Immunol 119:229-40. 2006
    ..In this review, we summarize the synthesis and secretion of PGE2. In particular, we focus on the three isoforms of the terminal PGES, and discuss the potential of targeting PGES as a more precise strategy for inhibiting PGE2 production...
  6. pmc Tumor microenvironment macrophage inhibitory factor directs the accumulation of interleukin-17-producing tumor-infiltrating lymphocytes and predicts favorable survival in nasopharyngeal carcinoma patients
    Jiang Li
    State Key Laboratory of Oncology in South China
    J Biol Chem 287:35484-95. 2012
    ..Taken together, our findings illustrate that tumor-derived MIF can affect patient prognosis, which might be related to the increase of Th17 cells in the NPC tumor microenvironment...
  7. ncbi Identification and characterization of a novel type of membrane-associated prostaglandin E synthase
    Naomi Tanikawa
    Special Division for Human Life Technology, Cell Dynamics Research Group, National Institute of AIST, Midorigaoka, Ikeda, Osaka 563 8577, Japan
    Biochem Biophys Res Commun 291:884-9. 2002
    ....
  8. ncbi Molecular identification of cytosolic prostaglandin E2 synthase that is functionally coupled with cyclooxygenase-1 in immediate prostaglandin E2 biosynthesis
    T Tanioka
    Department of Health Chemistry, School of Pharmaceutical Sciences, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142, Japan
    J Biol Chem 275:32775-82. 2000
    ..Thus, functional coupling between COX-1 and cPGES/p23 may contribute to production of the PGE(2) that plays a role in maintenance of tissue homeostasis...
  9. ncbi Role of macrophage migration inhibitory factor in primary glioblastoma multiforme cells
    Nina Baron
    Department of Neurology, Philipps University Marburg, Marburg, Germany
    J Neurosci Res 89:711-7. 2011
    ..These results underscore the importance of MIF in GBM and show that MIF and its receptors may be a promising target for the treatment of malignant gliomas...
  10. pmc Cytochrome P450-dependent metabolism of oxylipins in tomato. Cloning and expression of allene oxide synthase and fatty acid hydroperoxide lyase
    G A Howe
    Department of Energy Plant Research Laboratory, Michigan State University, East Lansing 48824, USA
    Plant Physiol 123:711-24. 2000
    ..These results demonstrate that tomato uses genetically distinct signaling pathways for the regulation of different classes of wound responsive genes...
  11. pmc Cardiac macrophage migration inhibitory factor inhibits JNK pathway activation and injury during ischemia/reperfusion
    Dake Qi
    Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA
    J Clin Invest 119:3807-16. 2009
    ..These data indicate that endogenous MIF inhibits JNK pathway activation during reperfusion and protects the heart from injury. These findings have clinical implications for patients with the low-expression MIF allele...
  12. ncbi The proinflammatory cytokine macrophage migration inhibitory factor regulates glucose metabolism during systemic inflammation
    Toshiya Atsumi
    Graduate School of Medicine, Hokkaido University, Sapporo, Japan
    J Immunol 179:5399-406. 2007
    ..Genetic MIF deficiency also promotes adipogenesis, which is in accord with a downstream role for MIF in the action of TNF-alpha. These studies support an important role for MIF in host glucose metabolism during sepsis...
  13. ncbi Role of MIF in inflammation and tumorigenesis
    Jan Philipp Bach
    Institute of Immunology, Philipps University Marburg, Marburg, Germany
    Oncology 75:127-33. 2008
    ..This review provides an overview of the involvement of MIF in both autoimmune disorders and tumorigenesis and summarizes the molecular action of MIF in this context...
  14. ncbi Macrophage migration inhibitory factor contributes angiogenesis by up-regulating IL-8 and correlates with poor prognosis of patients with primary nasopharyngeal carcinoma
    Bing Liao
    Department of Pathology, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou, China
    J Surg Oncol 102:844-51. 2010
    ..We aim at the association of macrophage migration inhibitory factor (MIF) with neovascularization and survival of nasopharyngeal carcinoma (NPC), and determine whether MIF is a valuable prognostic predictor for NPC patients...
  15. ncbi Membrane-associated PGE synthase-1 (mPGES-1) is coexpressed with both COX-1 and COX-2 in the kidney
    Andre Schneider
    Division of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Kidney Int 65:1205-13. 2004
    ..The present studies were aimed at determining the intrarenal localization of mPGES-1 and whether it is coexpressed with COX-1 or COX-2...
  16. ncbi Selective augmentation of prostacyclin production by combined prostacyclin synthase and cyclooxygenase-1 gene transfer
    S K Shyue
    Vascular Biology Program, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
    Circulation 103:2090-5. 2001
    ..Combined COX-1 and PGIS gene transfer has the potential for therapeutic augmentation of prostacyclin...
  17. pmc Allosteric inhibition of macrophage migration inhibitory factor revealed by ibudilast
    Yoonsang Cho
    Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 107:11313-8. 2010
    ..In addition, our antibody experiments directed against MIF receptors indicate that CXCR2 is the major receptor for MIF-mediated chemotaxis of peripheral blood mononuclear cells...
  18. ncbi Cloning, molecular and functional characterization of Arabidopsis thaliana allene oxide synthase (CYP 74), the first enzyme of the octadecanoid pathway to jasmonates
    D Laudert
    Lehrstuhl fur Pflanzenphysiologie, Ruhr Universitat Bochum, Germany
    Plant Mol Biol 31:323-35. 1996
    ..The data suggest parallel pathways to jasmonates from linolenic acid or linoleic acid in A. thaliana...
  19. ncbi Prostaglandin E2 as a mediator of fever: synthesis and catabolism
    Andrei I Ivanov
    Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322, USA
    Front Biosci 9:1977-93. 2004
    ..The high magnitude of up-regulation of mPGES and sPLA2-IIA (1,260 and 130 fold, respectively) and that of down-regulation of 15-PGES (30 fold) during LPS fever makes these enzymes attractive targets for anti-inflammatory therapy...
  20. ncbi Structural insights into the evolutionary paths of oxylipin biosynthetic enzymes
    Dong Sun Lee
    Department of Biochemistry and Molecular Biology, University of Texas Medical School, Houston, Texas 77030, USA
    Nature 455:363-8. 2008
    ..These results indicate that oxylipin biosynthetic genes were present in the last common ancestor of plants and animals, but were subsequently lost in all metazoan lineages except Placozoa, Cnidaria and Cephalochordata...
  21. pmc Upregulation of cyclooxygenase-2 (COX-2) and microsomal prostaglandin E2 synthase-1 (mPGES-1) in wall of ruptured human cerebral aneurysms: preliminary results
    David Hasan
    Department of Neurosurgery, Carver College of Medicine, University of Iowa, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, JCP 1616, Iowa City, IA 52242, USA
    Stroke 43:1964-7. 2012
    ..The upregulation of COX-2/mPGES-1 in the wall of ruptured human cerebral aneurysms is not known...
  22. ncbi Panel of markers can accurately predict endometriosis in a subset of patients
    Beata Seeber
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Fertil Steril 89:1073-81. 2008
    ..To evaluate whether a combination of putative markers of inflammation and CA-125 could serve as a multiple-marker screening test for endometriosis in a heterogeneous population of patients...
  23. pmc Macrophage migration inhibitory factor stimulates interleukin-17 expression and production in lymph node cells
    Ivana Stojanovic
    Department of Immunology, Institute for Biological Research Sinisa Stankovic, University of Belgrade, Belgrade, Serbia
    Immunology 126:74-83. 2009
    ....
  24. ncbi Microsomal prostaglandin E synthase-1 and 5-lipoxygenase: potential drug targets in cancer
    O Radmark
    Department of Medical Biochemistry and Biophysics, Division of Physiological Chemistry II, Karolinska Institutet, Stockholm, Sweden
    J Intern Med 268:5-14. 2010
    ..Several compounds that target COX-2 or MPGES-1 also inhibit 5-lipoxygenase. This may be advantageous for treatment of some forms of cancer...
  25. ncbi Prostaglandin E synthases: Understanding their pathophysiological roles through mouse genetic models
    Shuntaro Hara
    Department of Health Chemistry, School of Pharmaceutical Sciences, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    Biochimie 92:651-9. 2010
    ..In this review, we summarize the current understanding of the in vivo roles of PGES enzymes by knockout mouse studies and provide an overview of their biochemical properties...
  26. pmc Structures of Leishmania major orthologues of macrophage migration inhibitory factor
    Julia M Richardson
    School of Biological Sciences, University of Edinburgh, Mayfield Road, Edinburgh EH9 3JR, Scotland, UK
    Biochem Biophys Res Commun 380:442-8. 2009
    ..Analysis of the Leishmania braziliensis genome showed that this species lacks both MIF genes. Thus MIF is not a virulence factor in all species of Leishmania...
  27. ncbi Structure and regulation of the Arabidopsis thaliana allene oxide synthase gene
    I Kubigsteltig
    Lehrstuhl fur Pflanzenphysiologie, Ruhr Universitat, Bochum, Germany
    Planta 208:463-71. 1999
    ..Rather, the data show that jasmonates behave as local response regulators produced at or around the sites of action in response to appropriate triggers of their synthesis...
  28. pmc Microsomal prostaglandin E synthase-2: cellular distribution and expression in Alzheimer's disease
    Uzma Chaudhry
    Department of Anesthesiology Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Exp Neurol 223:359-65. 2010
    ..Furthermore, the high immunoreactivity of mPGES-2 in pyramidal neurons of AD brains indicates that it might have a potential role in the functional replacement of cytosolic PGES or inactive mPGES-1 in later stages of AD...
  29. ncbi Chromosomal structure of the human TYRP1 and TYRP2 loci and comparison of the tyrosinase-related protein gene family
    R A Sturm
    Centre for Molecular and Cellular Biology, University of Queensland, Australia
    Genomics 29:24-34. 1995
    ..The evidence also suggests that at least some of the introns within the TYR, TYRP1, and TYRP2 coding regions were gained after duplication and that intron slippage is unlikely to have occurred...
  30. pmc Null mutation for macrophage migration inhibitory factor (MIF) is associated with less aggressive bladder cancer in mice
    John A Taylor
    Division of Urology, University of Connecticut Health Center, Farmington, CT, USA
    BMC Cancer 7:135. 2007
    ..We studied the development of bladder cancer in wild type (WT) and MIF knockout (KO) mice given N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN), a known carcinogen, to determine the role of MIF in bladder cancer initiation and progression...
  31. pmc Modes of heme binding and substrate access for cytochrome P450 CYP74A revealed by crystal structures of allene oxide synthase
    Lenong Li
    Plant Biology Division, Samuel Roberts Noble Foundation, 2510 Sam Noble Parkway, Ardmore, OK 73401, USA
    Proc Natl Acad Sci U S A 105:13883-8. 2008
    ..These studies provide both structural insights into AOS and related P450s and a structural basis to understand the distinct reaction mechanism...
  32. ncbi Plant-derived anti-inflammatory compounds affect MIF tautomerase activity
    Valeria Molnar
    Department of Pathophysiology, Faculty of Medicine, University of Pecs, 12, Szigeti Str H 7624 Pécs, Hungary
    Int Immunopharmacol 5:849-56. 2005
    ..Resveratrol and umbelliferon were almost as potent inhibitors as the antipyretic-analgetic drug acetaminophen. Our results reveal MIF as a possible target for the herbal anti-rheumatic agents...
  33. ncbi Combination of lentivector immunization and low-dose chemotherapy or PD-1/PD-L1 blocking primes self-reactive T cells and induces anti-tumor immunity
    Sophie R Sierro
    Ludwig Center for Cancer Research of the University of Lausanne, Epalinges, Switzerland
    Eur J Immunol 41:2217-28. 2011
    ..We show here that combining rLV vaccination with either cyclophosphamide or PD-1 and PD-L1 blocking antibodies enhances rLV vaccination efficacy and improves anti-tumor immunity...
  34. ncbi Macrophage migration inhibitory factor (MIF) tautomerase inhibitors as potential novel anti-inflammatory agents: current developments
    Janos Garai
    Department of Pathophysiology, University of Pecs, Medical School, Hungary
    Curr Med Chem 16:1091-114. 2009
    ..The structural pattern of MIF enzyme inhibitors exhibits wide variety; compounds having quite different molecular backbones belong to the MIF inhibitor family. In this paper, the separate classes of MIF inhibitors are discussed...
  35. ncbi Human vascular smooth muscle cells but not endothelial cells express prostaglandin E synthase
    M Soler
    Laboratory of Inflammation Mediators, Institute of Research of Hospital Santa Creu i Sant Pau, Barcelona, Spain
    Circ Res 87:504-7. 2000
    ..Whereas SMC stimulation led to an increase in the synthesis of PGE(2) and PGI(2) but not of untransformed PGH(2), stimulation of endothelial cells resulted in an enhanced release of the vasoconstricting prostanoid PGH(2)...
  36. pmc Microsomal prostaglandin E synthase-1: the inducible synthase for prostaglandin E2
    Annaleise V Sampey
    University of Michigan, Ann Arbor, MI, USA
    Arthritis Res Ther 7:114-7. 2005
    ..The focus of this article is to review some recent advances in our understanding of mechanisms specific to the regulation of inducible mPGES-1 in inflammatory arthritis...
  37. ncbi Licofelone suppresses prostaglandin E2 formation by interference with the inducible microsomal prostaglandin E2 synthase-1
    Andreas Koeberle
    Pharmaceutical Institute, University of Tuebingen, Auf der Morgenstelle 8, D 72076 Tuebingen, Germany
    J Pharmacol Exp Ther 326:975-82. 2008
    ....
  38. ncbi Genetic analysis of melanophore development in zebrafish embryos
    R N Kelsh
    Max Planck Institute für Entwicklungsbiologie, Abteilung III, Spemannstrasse 35, Tubingen, D 72076, Germany
    Dev Biol 225:277-93. 2000
    ..Furthermore, their distribution indicates a defect in melanoblast dispersal. These observations permit us to refine our model of the genetic control of melanophore development in zebrafish embryos...
  39. pmc A critical role for the host mediator macrophage migration inhibitory factor in the pathogenesis of malarial anemia
    Michael A McDevitt
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Exp Med 203:1185-96. 2006
    ..These data suggest that polymorphisms at the MIF locus may influence the levels of MIF produced in the innate response to malaria infection and the likelihood of anemic complications...
  40. pmc The D-dopachrome tautomerase (DDT) gene product is a cytokine and functional homolog of macrophage migration inhibitory factor (MIF)
    Melanie Merk
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 108:E577-85. 2011
    ..These data indicate that D-DT is a MIF-like cytokine with an overlapping spectrum of activities that are important for our understanding of MIF-dependent physiology and pathology...
  41. ncbi Carrageenan-induced paw edema in rat elicits a predominant prostaglandin E2 (PGE2) response in the central nervous system associated with the induction of microsomal PGE2 synthase-1
    Jocelyne Guay
    Department of Biochemistry and Molecular Biology, Merck Frosst Centre for Therapeutic Research, Kirkland, Quebec H9H 3L1, Canada
    J Biol Chem 279:24866-72. 2004
    ..The data also indicate that the up-regulation of mPGES-1 contributes to COX-2-mediated PGE(2) production in the CNS during peripheral inflammation...
  42. ncbi Regulation of prostaglandin E2 synthase expression in activated primary rat microglia: evidence for uncoupled regulation of mPGES-1 and COX-2
    Antonio Carlos Pinheiro de Oliveira
    Department of Psychiatry, University of Freiburg Medical School, Freiburg, Germany
    Glia 56:844-55. 2008
    ....
  43. ncbi Endogenous macrophage migration inhibitory factor modulates glucocorticoid sensitivity in macrophages via effects on MAP kinase phosphatase-1 and p38 MAP kinase
    Daniel Aeberli
    Centre for Inflammatory Diseases, Department of Medicine, Monash Medical Centre, Monash University, Clayton, Melbourne, Australia
    FEBS Lett 580:974-81. 2006
    ..These results demonstrate that MIF regulates GC sensitivity by phosphorylation of p38, and provides a cellular mechanism for this observation, indicating that MKP-1 is a central target of this regulation...
  44. ncbi Macrophage migration inhibitory factor induces MMP-9 expression in macrophages via the MEK-ERK MAP kinase pathway
    Xiyong Yu
    The Guangdong Provincial Cardiovascular Institute, Guangdong Provincial People s Hospital, Guangzhou 510080, China
    J Interferon Cytokine Res 27:103-9. 2007
    ..MIF activates the MEK-ERK MAP kinase pathway to induce MMP-9 expression by murine macrophages. Activation of this pathway is necessary for MMP-9 expression and activation in response to MIF stimulation...
  45. pmc Essential role for hematopoietic prostaglandin D2 synthase in the control of delayed type hypersensitivity
    Seema G Trivedi
    Experimental Pathology, St Bartholomew s and the London School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, United Kingdom
    Proc Natl Acad Sci U S A 103:5179-84. 2006
    ..Consequently, hPGD(2)S-derived cyclopentenone PGs may protect against inflammatory diseases, where T lymphocytes play a pathogenic role, as in rheumatoid arthritis, atopic eczema, and chronic rejection...
  46. ncbi Microsomal prostaglandin E synthase (mPGES)-1, mPGES-2 and cytosolic PGES expression in human gastritis and gastric ulcer tissue
    Katya Gudis
    Third Department of Internal Medicine, Nippon Medical School, Sendagi, Bunkyo ku, Tokyo, Japan
    Lab Invest 85:225-36. 2005
    ....
  47. pmc A second tyrosinase-related protein, TRP-2, is a melanogenic enzyme termed DOPAchrome tautomerase
    K Tsukamoto
    Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892
    EMBO J 11:519-26. 1992
    ..We now report that TRP-2 (tyrosinase related protein-2), which maps to and is mutated at the slaty locus in mice, encodes a protein with DOPAchrome tautomerase activity...
  48. ncbi Recent advances in molecular biology and physiology of the prostaglandin E2-biosynthetic pathway
    Makoto Murakami
    Department of Health Chemistry, School of Pharmaceutical Sciences, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    Prog Lipid Res 43:3-35. 2004
    ..In this review, we will overview a recent understanding of the molecular biology, regulatory mechanisms, and physiological functions of these enzymes...
  49. ncbi Positioning prostanoids of the D and J series in the immunopathogenic scheme
    J L Herlong
    Department of Biological Sciences, 132 Long Hall, Clemson University, Clemson, SC 29634, USA
    Immunol Lett 102:121-31. 2006
    ..This review highlights the collective relevance of PGD(2) and its respective synthases, receptors, and metabolites in immunopathologic responses...
  50. ncbi Melanoblasts' proper location and timed differentiation depend on Notch/RBP-J signaling in postnatal hair follicles
    Geneviève Aubin-Houzelstein
    INRA, UMR955 Génétique Moléculaire et Cellulaire Ecole Nationale Vétérinaire d Alfort, Maisons Alfort, France
    J Invest Dermatol 128:2686-95. 2008
    ..These findings reveal previously unrecognized roles for Notch signaling in the melanocyte lineage...
  51. ncbi Novel prostaglandin D synthase inhibitors generated by fragment-based drug design
    Morten Hohwy
    Global Structural Chemistry and Global Compound Sciences, AstraZeneca Research and Development, S 43183 Mölndal, Sweden
    J Med Chem 51:2178-86. 2008
    ..The best inhibitor (IC 50 = 21 nM) is one of the most potent inhibitors of PGDS to date. As such, it may enable new functional in vivo studies of PGDS and the prostaglandin metabolism pathway...
  52. pmc Nutrient isothiocyanates covalently modify and inhibit the inflammatory cytokine macrophage migration inhibitory factor (MIF)
    Janet V Cross
    Department of Pathology, University of Virginia, Charlottesville, VA 22908, USA
    Biochem J 423:315-21. 2009
    ..Due to the emerging role of MIF in the control of malignant cell growth and its clear involvement in inflammation, inhibition of MIF by nutrient ITCs suggests therapeutic strategies for inflammatory diseases and cancer...
  53. pmc An interaction between L-prostaglandin D synthase and arrestin increases PGD2 production
    Karine Mathurin
    Service de Rhumatologie, Departement de Medecine, Faculte de Medecine et des Sciences de la Sante, Universite de Sherbrooke, Sherbrooke, Quebec J1H 5N4, Canada
    J Biol Chem 286:2696-706. 2011
    ....
  54. ncbi Hematopoietic prostaglandin D synthase suppresses intestinal adenomas in ApcMin/+ mice
    Jae Man Park
    Division of Medical Genetics, Department of Pediatrics and Department of Pathology, Los Angeles Biomedical Research Institute, Harbor University of California Los Angeles Medical Center, 1124 West Carson Street, Torrance, CA 90502, USA
    Cancer Res 67:881-9. 2007
    ..Further studies will be needed to prove possible mechanisms, such as routing of PG production away from protumorigenic PGE(2) or inhibition of the nuclear factor-kappaB cascade by PGD(2) metabolites...
  55. pmc Structural basis of the catalytic mechanism operating in open-closed conformers of lipocalin type prostaglandin D synthase
    Takashi Kumasaka
    Structural Biophysics Laboratory, RIKEN SPring 8 Center, Harima Institute, Kouto, Sayo, Hyogo 679 5148, Japan
    J Biol Chem 284:22344-52. 2009
    ..The conformational change between the open and closed states of the cavity indicates that the mobile calyx contributes to the multiligand binding ability of L-PGDS...
  56. ncbi Development and characterization of new inhibitors of the human and mouse hematopoietic prostaglandin D(2) synthases
    Angelika N Christ
    Institute for Molecular Bioscience, The University of Queensland, Queensland, Australia
    J Med Chem 53:5536-48. 2010
    ..Compound 34 therefore represents a selective hematopoietic prostaglandin D(2) synthase inhibitor...
  57. pmc Expression of prostaglandin E synthases in periodontitis immunolocalization and cellular regulation
    Tove Båge
    Division of Pediatric Dentistry, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
    Am J Pathol 178:1676-88. 2011
    ..These results suggest that fibroblasts and smooth muscle cells are important sources of mPGES-1, which may contribute to increased PGE(2) production in the inflammatory condition periodontitis...
  58. pmc Glucocorticoid protects rodent hearts from ischemia/reperfusion injury by activating lipocalin-type prostaglandin D synthase-derived PGD2 biosynthesis
    Satori Tokudome
    Department of Regenerative Medicine and Advanced Cardiac Therapeutics, School of Medicine, Keio University, Tokyo, Japan
    J Clin Invest 119:1477-88. 2009
    ..Taken together, these results suggest what we believe to be a novel interaction between glucocorticoid-GR signaling and the cardiomyocyte survival pathway mediated by the arachidonic acid cascade...
  59. pmc Curcumin modulates the immune response associated with LPS-induced periodontal disease in rats
    Morgana R Guimarães
    Department of Diagnosis and Surgery, Faculdade de Odontologia de Araraquara, Univ Estadual Paulista, Araraquara, SP, Brazil
    Innate Immun 18:155-63. 2012
    ..Curcumin potently inhibits innate immune responses associated with periodontal disease, suggesting a therapeutic potential in this chronic inflammatory condition...
  60. ncbi Molecular cloning and spatiotemporal expression of prostaglandin F synthase and microsomal prostaglandin E synthase-1 in porcine endometrium
    Agnieszka Waclawik
    Institute of Animal Reproduction and Food Research of Polish Academy of Sciences, 10 747 Olsztyn, Poland
    Endocrinology 147:210-21. 2006
    ..Moreover, high expression of both PG synthases after initiation of implantation may indicate their significant role in placentation...
  61. ncbi Interleukin-1beta and macrophage migration inhibitory factor (MIF) in dermal fibroblasts mediate UVA-induced matrix metalloproteinase-1 expression
    Ayumi Honda
    Department of Dermatology, Graduate School of Medicine, University of Toyama, Toyama, Japan
    J Dermatol Sci 49:63-72. 2008
    ..Matrix metalloproteinases (MMP)-1 is a member of the MMP family and degrades types I and III collagens, which are the major structural components of the dermis...
  62. pmc Macrophage migration inhibitory factor plays a permissive role in the maintenance of cardiac contractile function under starvation through regulation of autophagy
    Xihui Xu
    Center for Cardiovascular Research and Alternative Medicine, School of Pharmacy, University of Wyoming College of Health Sciences, Laramie, WY 82071, USA
    Cardiovasc Res 99:412-21. 2013
    ..This study was designed to examine the role of MIF in cardiac homeostasis and autophagy regulation following an acute starvation challenge...
  63. ncbi Prostaglandin D2 mediates neuronal protection via the DP1 receptor
    Xibin Liang
    Department of Neurology, Johns Hopkins University School of Medicine, 600 N Wolfe Street, Baltimore, MD 21205, USA
    J Neurochem 92:477-86. 2005
    ..Taken together, these data support an emerging and paradoxical neuroprotective role of prostaglandins in the CNS...
  64. ncbi Prostaglandin H2 induces the migration of human eosinophils through the chemoattractant receptor homologous molecule of Th2 cells, CRTH2
    Rufina Schuligoi
    Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Universitaetsplatz 4 A 8010 Graz, Austria
    J Leukoc Biol 85:136-45. 2009
    ..These data indicate that PGH2 causes activation of the PGD2 receptors CRTH2 and DP via a dual mechanism: by interacting directly with the receptors and/or by giving rise to PGD2 after catalytic conversion by plasma proteins...
  65. pmc A small-molecule macrophage migration inhibitory factor antagonist protects against glomerulonephritis in lupus-prone NZB/NZW F1 and MRL/lpr mice
    Lin Leng
    Department of Medicine, Yale University, New Haven, CT 06520, USA
    J Immunol 186:527-38. 2011
    ..These data highlight the feasibility of targeting the MIF-MIF receptor interaction by small-molecule antagonism and support the therapeutic value of downregulating MIF-dependent pathways of tissue damage in systemic lupus erythematosus...
  66. ncbi PPARgamma inhibition of cyclooxygenase-2, PGE2 synthase, and inducible nitric oxide synthase in cardiac myocytes
    Mariela Mendez
    Hypertension and Vascular Research Division, Henry Ford Hospital, 2799 West Grand Blvd, Detroit, MI 48202 2689, USA
    Hypertension 42:844-50. 2003
    ..We concluded that 15dPGJ2 may play an anti-inflammatory role in a PPARgamma-dependent manner, decreasing COX-2, PGES, and PGE2 production, as well as iNOS expression...
  67. ncbi Crystal structure of human D-dopachrome tautomerase, a homologue of macrophage migration inhibitory factor, at 1.54 A resolution
    H Sugimoto
    Division of Biological Sciences, Graduate School of Science, Hokkaido University, Sapporo, Japan
    Biochemistry 38:3268-79. 1999
    ..The present structural study could be helpful for designing effective inhibitors that modulate immunoregulatory and hormone-like effects...
  68. pmc Inhibition of microsomal prostaglandin E2 synthase-1 as a molecular basis for the anti-inflammatory actions of boswellic acids from frankincense
    U Siemoneit
    Pharmaceutical Institute, University of Tuebingen, Tuebingen, Germany
    Br J Pharmacol 162:147-62. 2011
    ..Boswellic acids (BAs) are assumed to be responsible for these effects but their anti-inflammatory efficacy in vivo and their molecular modes of action are incompletely understood...
  69. pmc mPGES-1 as a target for cancer suppression: A comprehensive invited review "Phospholipase A2 and lipid mediators"
    Masako Nakanishi
    Center for Molecular Medicine, University of Connecticut Health Center, 263 Farmington Ave, Farmington, CT 06030 3101, USA
    Biochimie 92:660-4. 2010
    ..The role of mPGES-1 in the pathogenesis of various cancers is discussed. In addition, an overview of recent efforts to develop small molecule inhibitors that target the protein with high selectivity is also be reviewed...
  70. ncbi Metabolic profiling of oxylipins in germinating cucumber seedlings--lipoxygenase-dependent degradation of triacylglycerols and biosynthesis of volatile aldehydes
    Heiko Weichert
    Institute oof Plant Genetics and Crop Plant Research IPK, Gatersleben, Germany
    Planta 215:612-9. 2002
    ..The first evidence is presented for an involvement of a lipid-body LOX form in the production of volatile aldehydes...
  71. pmc Piebald lethal (sl) acts early to disrupt the development of neural crest-derived melanocytes
    W J Pavan
    Department of Molecular Biology, Princeton University, NJ 08544 1014
    Proc Natl Acad Sci U S A 91:7159-63. 1994
    ..The non-uniform distribution of melanoblasts in wild-type mice suggests that piebald acts stochastically to affect melanocyte development...
  72. ncbi Macrophage migration inhibitory factor antagonizes pressure overload-induced cardiac hypertrophy
    Kiyokazu Koga
    Center for Heart and Lung Research, The Feinstein Institute for Medical Research, Manhasset, NY 11030, USA
    Am J Physiol Heart Circ Physiol 304:H282-93. 2013
    ..We conclude that MIF antagonizes myocardial hypertrophy and fibrosis in response to hemodynamic stress by maintaining a redox homeostatic phenotype and attenuating stress-induced activation of hypertrophic signaling pathways...
  73. pmc Molecular cloning of an allene oxide synthase: a cytochrome P450 specialized for the metabolism of fatty acid hydroperoxides
    W C Song
    Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232 6602
    Proc Natl Acad Sci U S A 90:8519-23. 1993
    ..The flaxseed enzyme is prototypical of this family of enzymes that remain to be characterized in plants and animals...
  74. pmc Crystal structure of microsomal prostaglandin E2 synthase provides insight into diversity in the MAPEG superfamily
    Tove Sjögren
    Discovery Sciences, AstraZeneca R and D Molndal, S 43183 Mölndal, Sweden
    Proc Natl Acad Sci U S A 110:3806-11. 2013
    ..We have also determined the structure of mPGES-1 in complex with a glutathione-based analog, providing insight into mPGES-1 flexibility and potential for structure-based drug design...
  75. ncbi Lipopolysaccharide-dependent prostaglandin E(2) production is regulated by the glutathione-dependent prostaglandin E(2) synthase gene induced by the Toll-like receptor 4/MyD88/NF-IL6 pathway
    Satoshi Uematsu
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan
    J Immunol 168:5811-6. 2002
    ..Thus, mPGES is critically involved in the biosynthesis of PGE(2) induced by LPS, but is dispensable for the modulation of inflammatory responses...
  76. ncbi Cloning and functional analysis of an allene oxide synthase in Physcomitrella patens
    P K G S S Bandara
    Division of Applied Bioscience, Research Faculty of Agriculture, Hokkaido University, Sapporo, Japan
    Biosci Biotechnol Biochem 73:2356-9. 2009
    ..In this study, the presence of JA was detected in P. patens. The recombinant AOS of P. patens, which was overexpressed in Escherichia coli, showed AOS activity. These data suggest that the octadecanoid pathway also exists in P. patens...
  77. pmc HIF1alpha delays premature senescence through the activation of MIF
    Scott M Welford
    Division of Radiation and Cancer Biology, Stanford University, Stanford, California 94305, USA
    Genes Dev 20:3366-71. 2006
    ..Inhibition of MIF phenocopies loss of HIF1alpha. Our findings highlight a novel role for HIF1alpha under aerobic conditions, and identify MIF as a target responsible for this function...
  78. ncbi Prostaglandin D synthase (beta-trace) in healthy human sleep
    Wolfgang Jordan
    Department of Psychiatry and Psychotherapy, University of Gottingen, Germany
    Sleep 27:867-74. 2004
    ..Assessment of this system's activity in relation to human physiologic sleep was the target of the present study...
  79. ncbi Lipocalin-type prostaglandin D synthase is a powerful biomarker for severity of stable coronary artery disease
    Teruo Inoue
    Department of Cardiovascular and Renal Medicine, Saga University Faculty of Medicine, Saga, Japan
    Atherosclerosis 201:385-91. 2008
    ..55, P<0.0001). The serum L-PGDS level is suitable to evaluate the severity of coronary artery disease. The measurement of serum L-PGDS can be a strategy for screening of stable coronary artery disease prior to coronary angiography...
  80. ncbi The AOC promoter of tomato is regulated by developmental and environmental stimuli
    Irene Stenzel
    Leibniz Institute of Plant Biochemistry, Department of Natural Product Biotechnology, Weinberg 3, D 06120 Halle Saale, Germany
    Phytochemistry 69:1859-69. 2008
    ..The data support a spatial and temporal regulation of JA biosynthesis during development and in response to environmental stimuli...
  81. ncbi Change in prostaglandin E synthases (PGESs) in microsomal PGES-1 knockout mice in a preterm delivery model
    Ken Kubota
    Department of Cellular Physiological Chemistry, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    J Endocrinol 187:339-45. 2005
    ..The present data indicate that mPGES-1 may be involved in LPS-induced preterm labor, but inhibition of mPGES-1 alone may not prevent preterm delivery, because mPGES-2 might compensate for the role of mPGES-1...
  82. ncbi Linolenate 9R-dioxygenase and allene oxide synthase activities of Lasiodiplodia theobromae
    Fredrik Jernerén
    Department of Pharmaceutical Biosciences, Uppsala Biomedical Center, Uppsala University, P O Box 591, 75124 Uppsala, Sweden
    Lipids 47:65-73. 2012
    ..This strain also lacked the JA biosynthetic enzymes present in higher plants...
  83. pmc Different cis-acting elements are involved in the regulation of TRP1 and TRP2 promoter activities by cyclic AMP: pivotal role of M boxes (GTCATGTGCT) and of microphthalmia
    C Bertolotto
    INSERM U385, Biologie et Physiopathologie de la Peau, Faculte de Medecine, Nice, France
    Mol Cell Biol 18:694-702. 1998
    ..These convergent and compelling results disclose at least a part of the molecular mechanism involved in the regulation of melanogenic gene expression by cAMP and emphasize the pivotal role of microphthalmia in this process...
  84. pmc Competitive enzymatic interactions determine the relative amounts of prostaglandins E2 and D2
    Rui Yu
    Department of Medicinal Chemistry and Pharmacognosy, University of Illinois College of Pharmacy, 833 S Wood Street, Chicago, IL 60612 7231, USA
    J Pharmacol Exp Ther 339:716-25. 2011
    ....
  85. ncbi The cardinal role of the phospholipase A(2)/cyclooxygenase-2/prostaglandin E synthase/prostaglandin E(2) (PCPP) axis in inflammostasis
    A D Mancini
    Department of Anatomy and Cell Biology, McGill University, 3640 University St, Montreal, QC H3A 2B2, Canada
    Inflamm Res 60:1083-92. 2011
    ....
  86. ncbi The macrophage migration inhibitory factor MIF is a phenylpyruvate tautomerase
    E Rosengren
    Department of Pharmacology, University of Lund, Sweden
    FEBS Lett 417:85-8. 1997
    ..3.2.1) having p-hydroxyphenylpyruvate and phenylpyruvate as its natural substrates. The definition of MIF as an enzyme may yield insight into the mechanism of action of this proinflammatory and immunomodulating cytokine...
  87. pmc Microsomal prostaglandin E synthase-1 in both cancer cells and hosts contributes to tumour growth, invasion and metastasis
    Daisuke Kamei
    The Department of Health Chemistry, School of Pharmacy, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    Biochem J 425:361-71. 2010
    ..Thus our present approaches provide unequivocal evidence for critical roles of the mPGES-1-dependent PGE2 biosynthetic pathway in both cancer cells and host microenvironments in tumour growth and metastasis...
  88. pmc Potent anti-inflammatory effects of systemically administered curcumin modulate periodontal disease in vivo
    M R Guimaraes
    Department of Diagnosis and Surgery, Faculdade de Odontologia de Araraquara Univ Estadual Paulista UNESP, Araraquara, SP, Brazil
    J Periodontal Res 46:269-79. 2011
    ..Its therapeutic applications have been studied in a variety of conditions, including rheumatoid arthritis, colon cancer and depression, but no studies have evaluated the effects of curcumin on periodontal disease in vivo...
  89. pmc Macrophage migration inhibitory factor regulates proliferation of gastric cancer cells via the PI3K/Akt pathway
    Guo Qing Li
    Department of Gastroenterology, The Second Affiliated Hospital, University of South China, Hunan Province, China
    World J Gastroenterol 15:5541-8. 2009
    ....
  90. pmc Microsomal prostaglandin E synthase 1 determines tumor growth in vivo of prostate and lung cancer cells
    Hiromi Hanaka
    Department of Medical Biochemistry and Biophysics, Division of Physiological Chemistry II, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 106:18757-62. 2009
    ..The results suggest that MPGES-1 is an alternative therapeutic target in cancer cells expressing this enzyme...
  91. pmc Signal pathways JNK and NF-kappaB, identified by global gene expression profiling, are involved in regulation of TNFalpha-induced mPGES-1 and COX-2 expression in gingival fibroblasts
    Tove Båge
    Division of Pediatric Dentistry, Department of Dental Medicine, Karolinska Institutet, Huddinge, Sweden
    BMC Genomics 11:241. 2010
    ....
  92. ncbi Activation of adipogenesis by lipocalin-type prostaglandin D synthase-generated Δ¹²-PGJ₂ acting through PPARγ-dependent and independent pathways
    Ko Fujimori
    Laboratory of Biodefense and Regulation, Osaka University of Pharmaceutical Sciences, 4 20 1 Nasahara, Takatsuki, Osaka 569 1094, Japan
    Gene 505:46-52. 2012
    ....
  93. pmc N-terminal domain of human Hsp90 triggers binding to the cochaperone p23
    G Elif Karagöz
    Cellular Protein Chemistry, Bijvoet Center for Biomolecular Research, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands
    Proc Natl Acad Sci U S A 108:580-5. 2011
    ..We anticipate that our NMR approach has significant impact on future studies of full-length Hsp90 with cofactors and substrates, but also for the development of Hsp90 inhibiting anticancer drugs...
  94. ncbi Prostaglandin E(2) synthase inhibition as a therapeutic target
    Jitesh P Iyer
    Department of Pharmacology, New Drug Discovery Research, Ranbaxy Research Laboratories, Plot No 20, Sector 18, Udyog Vihar, Gurgaon, Haryana, India 122015
    Expert Opin Ther Targets 13:849-65. 2009
    ..This resulted in the drugs being withdrawn from the market, leaving a need for an effective and safe anti-inflammatory drug...
  95. ncbi The effect of ovarian steroids on oxytocin-stimulated secretion and synthesis of prostaglandins in bovine myometrial cells
    Dominika Slonina
    Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, 10 747 Olsztyn, Poland
    Prostaglandins Other Lipid Mediat 90:69-75. 2009
    ....
  96. doi Microsomal prostaglandin E2 synthase-1 (mPGES-1): a novel anti-inflammatory therapeutic target
    Richard W Friesen
    Department of Medicinal Chemistry, Merck Frosst Centre for Therapeutic Research, 16711 Trans Canada Highway, Kirkland, Quebec H9H 3L1, Canada
    J Med Chem 51:4059-67. 2008
  97. ncbi Contribution of macrophage migration inhibitory factor to the pathogenesis of dengue virus infection
    Iranaia Assunção-Miranda
    Programa de Biologia Estrutural, Departamento de Imunologia, Instituto de Microbiologia, CCS Bloco I, Universidade Federal do Rio de Janeiro, Avenida Carlos Chagas Filho 373, Cidade Universitaria, Rio de Janeiro RJ, 21941 902 Brazil
    FASEB J 24:218-28. 2010
    ..These results demonstrated the contribution of MIF to the pathogenesis of dengue and pointed to a possible beneficial role of neutralizing MIF as an adjunctive therapeutic approach to treat the severe forms of the disease...
  98. ncbi Substituted phenanthrene imidazoles as potent, selective, and orally active mPGES-1 inhibitors
    Bernard Cote
    Merck Frosst Centre for Therapeutic Research, 16711 Trans Canada Hwy, Kirkland, Que, Canada
    Bioorg Med Chem Lett 17:6816-20. 2007
    ..42 microM (50% FBS) and a human whole blood IC(50) of 1.3 microM. It exhibited a significant analgesic effect in a guinea pig hyperalgesia model when orally dosed at 30 and 100mg/kg...
  99. ncbi Tyrosinase-related protein 2 promoter targets transgene expression to ocular and neural crest-derived tissues
    S Zhao
    Department of Cell Biology, Baylor College of Medicine, Houston, Texas, 77030, USA
    Dev Biol 216:154-63. 1999
    ..These studies demonstrate that the TRP2 promoter is valuable for transgenic studies of ocular differentiation and development of neural crest cells...
  100. ncbi Expression of cyclooxygenase-1/-2, microsomal prostaglandin-E synthase-1 and E-prostanoid receptor 2 and regulation of inflammatory mediators by PGE(2) in the amoeboid microglia in hypoxic postnatal rats and murine BV-2 cells
    P Li
    Department of Histology and Embryology, Kunming Medical College, 191 West Renmin Road, PR China
    Neuroscience 164:948-62. 2009
    ..It is suggested that PGE(2) may regulate above inflammatory mediators in the activated microglia via EP2-cAMP signaling pathway in hypoxic conditions...
  101. ncbi Inhibitors of the microsomal prostaglandin E(2) synthase-1 as alternative to non steroidal anti-inflammatory drugs (NSAIDs)--a critical review
    A Koeberle
    Pharmaceutical Institute, University of Tuebingen, Auf der Morgenstelle 8, D 72076 Tuebingen, Germany
    Curr Med Chem 16:4274-96. 2009
    ..Further, the therapeutic efficiency and safety is critically discussed on the basis of cellular and animal studies in which mPGES-1 activity was pharmacologically or genetically (knockout, knockdown) modulated...

Research Grants56

  1. Control of Vascular Smooth Muscle Function by Insulin
    Louis Ragolia; Fiscal Year: 2006
    ..abstract_text> ..
  2. STRUCTURE & FUNCTION RELATIONSHIP: PROSTANOID RECEPTORS
    Ke He Ruan; Fiscal Year: 2008
    ..Determine the solution conformation of segments comprising the intracellular domains. ..
  3. Prostaglandin I synthase, Thromboxane A synthase & Prostaglandin E synthase
    Ke He Ruan; Fiscal Year: 2009
    ....
  4. NOVEL OXYGENATIONS OF ARACHIDONIC ACID
    ALAN BRASH; Fiscal Year: 2006
    ..These studies will develop new insights into the biochemistry of mammalian cyclooxygenases and as a consequence have practical benefits in development of therapeutics. ..
  5. PATHOPHYSIOLOGICAL ROLE OF 12-R-LIPOXYGENASE
    ALAN BRASH; Fiscal Year: 2002
    ..abstract_text> ..
  6. Prostanoids and hypoxic neonatal pulmonary hypertension
    CANDICE FIKE; Fiscal Year: 2009
    ..The goal of this project is to help us understand why infants develop pulmonary hypertension, determine what happens in the lung blood vessels during disease development, and develop treatments for this disease. ..
  7. Pigmentation and Diversity Conference
    ISABELLE LE POOLE; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  8. Neurobiology of MIF in development and disease
    Bradley Pearce; Fiscal Year: 2007
    ..Besides schizophrenia, these studies could provide insight into Parkinson's disease, and maternal mental illnesses. [unreadable] [unreadable] [unreadable]..
  9. Kynurenic Acid Synthesis in Mouse Brain
    Jianyong Li; Fiscal Year: 2010
    ..The research described in this proposal investigates physiology and biochemistry of enzymes responsible for the production of brain KYNA using mice as model species. ..
  10. Autoimmune vitiligo as a roadmap to melanoma therapy
    ISABELLE LE POOLE; Fiscal Year: 2007
    ..Importantly, the cloning of high affinity T cell receptors in retroviral vectors may be suitable for introduction into patient PBL for treatment of malignant melanoma. ..
  11. Alcohol-specific modifications of glycated Hb: Novel biomarkers of alcohol abuse
    Yousef Al Abed; Fiscal Year: 2007
    ..Future studies will be designed to measure these alcohol-specific-markers in humans following binge and chronic alcohol intake. [unreadable] [unreadable] [unreadable]..
  12. Ontogeny of Drug Bioactivation and Idiosyncratic ADRs
    JAMES LEEDER; Fiscal Year: 2007
    ..abstract_text> ..
  13. TRYPTOPHAN METABOLISM IN MOSQUITOES
    Jianyong Li; Fiscal Year: 2007
    ..Because both KAT and HKT are critical during mosquito development, they could be potential targets for future mosquito controls. [unreadable] [unreadable]..
  14. Aspirin for Breast Cancer Prevention
    LOUISE HOWE; Fiscal Year: 2006
    ..abstract_text> ..
  15. Interaction of COX-2 AND nNOS in renin secretion (R01)
    Tianxin Yang; Fiscal Year: 2008
    ..abstract_text> ..
  16. Chemopreventive treatment of familial melanoma
    ISABELLE LE POOLE; Fiscal Year: 2008
    ..3] To quantify melanoma tumor growth and measure immunologic parameters (cytokine secretion by ELISA and ELISPOT) in mice treated with bleaching agents and IL-2. [unreadable] [unreadable] [unreadable]..
  17. Neuroinflammation and Glial ROS in Methamphetamine Neurotoxicity
    Lisa A Opanashuk; Fiscal Year: 2010
    ..abstract_text> ..
  18. Cellular Mechanisms for the hormonal Modulation of Sleep
    Jessica Mong; Fiscal Year: 2009
    ..abstract_text> ..
  19. REGULATION OF AUTOIMMUNITY WITH T CELL RECEPTOR PEPTIDES
    Arthur A Vandenbark; Fiscal Year: 2010
    ..abstract_text> ..
  20. CNS Anti-tumor immunity induced by dendritic cell vaccination and TLR agonists
    Robert M Prins; Fiscal Year: 2010
    ..Thus, this is a mechanistic and translational project that is directly related to our long-term objectives stated above and to the mission of promoting public health. ..
  21. PHAGOCYTE RESOLVING METABOLISM
    Charles Serhan; Fiscal Year: 2009
    ..abstract_text> ..
  22. COX-2 Inhibitors, APC and Colon Cancer Prevention
    Kotha Subbaramaiah; Fiscal Year: 2009
    ..These studies will enhance our understanding of the mechanistic link between COX-2 and colorectal cancer and potentially assist us in optimizing the use of selective COX-2 inhibitors as therapy. ..
  23. Neuroinflammation in CNS Radiation Injury: IL-1 & COX-2
    MICHAEL O BANION; Fiscal Year: 2009
    ..This work will provide a better understanding of the molecular and cellular mechanisms contributing to early and delayed effects, and may directly implicate specific targets for prevention and treatment of brain radiation injury. ..
  24. Defining the Clinical Significance of HbA1c Prior to the Onset of Diabetes
    Elizabeth Selvin; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  25. New Serodiagnostics for Isocyanate Exposure, A Major Cause of Occupational Asthma
    ADAM WISNEWSKI; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  26. Genetics of Longevity and Age-Sensitive Traits in Mice
    Richard Miller; Fiscal Year: 2008
    ..abstract_text> ..
  27. IL-1nduced Mediators of CNS Inflammation and AD: PGE
    MICHAEL O BANION; Fiscal Year: 2006
    ..Moreover, these studies have relevance to pathological processes occurring in head trauma, stroke, and other neurodegenerative diseases where glial activation and inflammation-related changes take place. ..
  28. EXCITOTOXICITY IN THE HIPPOCAMPUS AFTER VIRAL INFECTION
    Bradley Pearce; Fiscal Year: 2002
    ..These studies aim to provide clues to the mechanisms by which an early viral infection could be involved in certain neurodevelopmental disorders. ..
  29. Combination Chemoprevention of ER-Negative Breast Cancer
    LOUISE HOWE; Fiscal Year: 2004
    ..The results of this study will provide the basis for evaluating this combination approach in women at high risk for breast cancer. ..
  30. Human Lung gamma/delta T cells, Antigens and Functions
    ADAM WISNEWSKI; Fiscal Year: 2004
    ..The results of these experiments should provide important insights into the role of airway mucosal gamma/delta T cells in maintaining human pulmonary immune homeostasis. ..
  31. Regulation of Prostaglandin E Synthases in Parturition
    William Ackerman; Fiscal Year: 2004
    ..We hope to support the hypothesis that, as in other systems, microsomal PGES is functionally linked to COX-2 in the generation of uterotonic POE2. ..
  32. WILD DERIVED MOUSE STOCKS--NEW MODELS FOR AGING RESEARCH
    Richard Miller; Fiscal Year: 2004
    ....
  33. SERINE PROTEASES AND IMMUNITY IN ANOPHELES GAMBIAE
    Susan Paskewitz; Fiscal Year: 2004
    ..Finally, several A. gambiae serine proteases that exhibit domain structures similar to other enzymes involved in immune responses will be characterized at the mRNA and protein levels. ..
  34. PROSTAGLANDINS IN PRIMATE OVULATORY FOLLICLES
    DIANE DUFFY; Fiscal Year: 2003
    ..This may provide insight into the mechanisms leading to infertility (e.g., leuteinized unruptured follice syndrome) and support the developoment of PG synthesis inhibitors of PG synthesis inhibitors for use as contraceptives. ..
  35. PATHOGENESIS OF ANTICONVULSANT HYPERSENSITIVITY SYNDROME
    JAMES LEEDER; Fiscal Year: 2003
    ..It is anticipated that the basic experimental paradigm employed for these studies can also be applied to other idiosyncratic toxicities with suspected drug bioactivation and immune etiologies. ..
  36. GENETICS OF AGE SENSITIVE TRAITS IN MICE
    Richard Miller; Fiscal Year: 2003
    ..At best, the program may permit the localization of loci that influence multiple age-sensitive domains and are thus plausible candidates for genes that regulate the rate of aging per se. ..
  37. EICOSANOIDS AND NO IN CEREBROVASCULAR THROMBOSIS
    Kenneth Wu; Fiscal Year: 2003
    ..It is intended that this program will enable several laboratories to work individually and together to achieve the highest degree of innovating and productivity. ..
  38. HEMEOXYGENASE1--REGULATION AND FUNCTION AFTER HYPEROXIA
    PATTY LEE; Fiscal Year: 2002
    ..3) Determine the functional role of HO-1 after hyperoxia in vitro following hyperoxia. 4) Determine the functional role of HO-1 after hyperoxia in vivo using HO- 1 transgenic and knock-out mice. ..
  39. SYNOVIOCYTE RHO-TYPE GTPASES IN CARTILAGE DESTRUCTION
    Leslie Crofford; Fiscal Year: 2002
    ..Ultimately, we will determine the effects of the Rho-type GTPases on synoviocyte adherence to and migration over articular cartilage, production of MMPs, and destruction of the cartilage matrix. ..
  40. Biochemistry of Chorion Hardening in Mosquitoes
    Jianyong Li; Fiscal Year: 2005
    ....
  41. Interaction of age and gender on NO bioavailability
    Jennifer Sullivan; Fiscal Year: 2005
    ..We will then determine the affects of age and gender on antioxidant systems and the sources of oxidative stress in the mesenteric vasculature. ..
  42. Cytokine-HPA Interactions During Pregnanacy
    Bradley Pearce; Fiscal Year: 2006
    ..Moreover, this study opens a new potential direction for therapeutics aimed at depression and obstetric complications. ..
  43. Clinical and molecular pathophysiology of headache
    Michael Harrington; Fiscal Year: 2006
    ..Delineation of these compositional differences should extend our pathophysiological understanding beyond the current theories, yield useful biomarkers and lead to more knowledge-based remedies or interventions. ..
  44. Arachidonic Acid Metabolism in Blood and Vascular Cells
    Jun Yang Liou; Fiscal Year: 2006
    ..Information provided by studies from this renewal application will have great impact on understanding the fundamental cytoprotection process and offer an excellent opportunity for developing new therapeutic agents. ..
  45. Development of a T cell specific multiple sclerosis drug
    Arthur Vandenbark; Fiscal Year: 2005
    ..The proposed studies will address key milestones to establish clinical safety of VG1000 needed for subsequent proof-of-principle trials to evaluate inhibition of MOG-specific T cell responses and clinical efficacy. ..
  46. Th1-to Th2 shift of HSP65 responses and atherogenesis
    Yoshimi Shibata; Fiscal Year: 2005
    ..Finally, we will determine if transfusion of fit-1 +marrow cells from HK-BCG treated WT donors will restore the Thl-to-Th2 shifts in 89Sr-treated WT recipients. ..
  47. Discovery of biomarkers of pulmonary hypertension
    Rubin Tuder; Fiscal Year: 2005
    ..abstract_text> ..
  48. Isocyanate Antigens and T-cells that Cause Asthma
    ADAM WISNEWSKI; Fiscal Year: 2005
    ..Together the results should provide significant insights into the pathogenesis of diisocyanate asthma. ..
  49. IL-1 in Neurodegeneration: Development of a New Model
    MICHAEL O BANION; Fiscal Year: 2005
    ..These transgenic mouse lines will provide a powerful model to explore the contribution of IL-1 to neurodegenerative disorders and other neurological conditions such as stroke and traumatic brain injury. ..
  50. Stress proteins in autoimmune depigmentation
    ISABELLE LE POOLE; Fiscal Year: 2005
    ..The same model will be of use to test the efficacy of therapeutic modalities to be developed for vitiligo in the future. ..
  51. Renal medullary COX-2 in blood pressure control
    Tianxin Yang; Fiscal Year: 2008
    ..The information resulted from these studies will provide new insight into the molecular mechanism responsible for long-term control of arterial blood pressure. ..
  52. Lysozymes and immunity in Anopheles gambiae
    Susan M Paskewitz; Fiscal Year: 2010
    ....
  53. Interaction of COX-2 and nNOS in renin secretion
    Tianxin Yang; Fiscal Year: 2006
    ....
  54. Generation of Collecting Duct Knockout of PPARgamma
    Tianxin Yang; Fiscal Year: 2006
    ..New information provided by this proposal is expected to provide insights into the roles of PPARgamma in regulation of fluid balance and in mediation of the side effects of TDZ. ..
  55. Tetrahydrobiopterin: Regulator of Endothelial Function
    ZVONIMIR KATUSIC; Fiscal Year: 2009
    ..This information may help to develop new strategies in prevention and treatment of endothelial dysfunction. . ..
  56. Nitric Oxide-Superoxide in Lipid Induced Vascular Diseas
    ZVONIMIR KATUSIC; Fiscal Year: 2005
    ....