matrix metalloproteinases

Summary

Summary: A family of zinc-dependent metalloendopeptidases that are involved in the degradation of EXTRACELLULAR MATRIX components. EC 3.4.24.-.

Top Publications

  1. ncbi New functions for the matrix metalloproteinases in cancer progression
    Mikala Egeblad
    Department of Anatomy, University of California at San Francisco, 94143 0452, USA
    Nat Rev Cancer 2:161-74. 2002
  2. pmc Matrix metalloproteinases: regulators of the tumor microenvironment
    Kai Kessenbrock
    Department of Anatomy and Biomedical Sciences Program, University of California, San Francisco, CA 94143 0452, USA
    Cell 141:52-67. 2010
  3. ncbi Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry
    Robert Visse
    Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College London, 1 Aspenlea Rd, London W6 8LH, UK
    Circ Res 92:827-39. 2003
  4. ncbi Matrix metalloproteinases and tumor metastasis
    Elena I Deryugina
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Cancer Metastasis Rev 25:9-34. 2006
  5. pmc How matrix metalloproteinases regulate cell behavior
    M D Sternlicht
    Department of Anatomy, University of California, San Francisco, California 94143 0452, USA
    Annu Rev Cell Dev Biol 17:463-516. 2001
  6. ncbi Structure and function of matrix metalloproteinases and TIMPs
    Hideaki Nagase
    Department of Matrix Biology, Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College London, 1 Aspenlea Road, London W6 8LH, UK
    Cardiovasc Res 69:562-73. 2006
  7. pmc Matrix metalloproteinases and the regulation of tissue remodelling
    Andrea Page-McCaw
    Department of Biology and Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York 12180, USA
    Nat Rev Mol Cell Biol 8:221-33. 2007
  8. pmc Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs): Positive and negative regulators in tumor cell adhesion
    Dimitra Bourboulia
    Radiation Oncology Branch, Center for Cancer Research, NCI NIH, Advanced Technology Center, 8717 Grovemont Circle, Bethesda, MD 20892 4605, USA
    Semin Cancer Biol 20:161-8. 2010
  9. ncbi Matrix metalloproteinases in tumorigenesis: an evolving paradigm
    Hui Hua
    State Key Laboratory of Biotherapy, Section of Signal Transduction and Molecular Targeted Therapy, West China Hospital, Sichuan University, Chengdu
    Cell Mol Life Sci 68:3853-68. 2011
  10. ncbi Myocardial matrix remodeling and the matrix metalloproteinases: influence on cardiac form and function
    Francis G Spinale
    Division of Cardiothoracic Surgery, Medical University of South Carolina, Charleston, South Carolina 29403, USA
    Physiol Rev 87:1285-342. 2007

Detail Information

Publications362 found, 100 shown here

  1. ncbi New functions for the matrix metalloproteinases in cancer progression
    Mikala Egeblad
    Department of Anatomy, University of California at San Francisco, 94143 0452, USA
    Nat Rev Cancer 2:161-74. 2002
    b>Matrix metalloproteinases (MMPs) have long been associated with cancer-cell invasion and metastasis. This provided the rationale for clinical trials of MMP inhibitors, unfortunately with disappointing results...
  2. pmc Matrix metalloproteinases: regulators of the tumor microenvironment
    Kai Kessenbrock
    Department of Anatomy and Biomedical Sciences Program, University of California, San Francisco, CA 94143 0452, USA
    Cell 141:52-67. 2010
    ..The matrix metalloproteinases (MMPs) represent the most prominent family of proteinases associated with tumorigenesis...
  3. ncbi Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry
    Robert Visse
    Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College London, 1 Aspenlea Rd, London W6 8LH, UK
    Circ Res 92:827-39. 2003
    b>Matrix metalloproteinases (MMPs), also designated matrixins, hydrolyze components of the extracellular matrix...
  4. ncbi Matrix metalloproteinases and tumor metastasis
    Elena I Deryugina
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Cancer Metastasis Rev 25:9-34. 2006
    Functions of individual matrix metalloproteinases (MMPs) differentially expressed by tumor cells and stromal cells, are finely regulated by their spatial as well as temporal interactions with distinct cellular and extracellular ..
  5. pmc How matrix metalloproteinases regulate cell behavior
    M D Sternlicht
    Department of Anatomy, University of California, San Francisco, California 94143 0452, USA
    Annu Rev Cell Dev Biol 17:463-516. 2001
    The matrix metalloproteinases (MMPs) constitute a multigene family of over 25 secreted and cell surface enzymes that process or degrade numerous pericellular substrates...
  6. ncbi Structure and function of matrix metalloproteinases and TIMPs
    Hideaki Nagase
    Department of Matrix Biology, Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College London, 1 Aspenlea Road, London W6 8LH, UK
    Cardiovasc Res 69:562-73. 2006
    b>Matrix metalloproteinases (MMPs), also called matrixins, function in the extracellular environment of cells and degrade both matrix and non-matrix proteins...
  7. pmc Matrix metalloproteinases and the regulation of tissue remodelling
    Andrea Page-McCaw
    Department of Biology and Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York 12180, USA
    Nat Rev Mol Cell Biol 8:221-33. 2007
    b>Matrix metalloproteinases (MMPs) were discovered because of their role in amphibian metamorphosis, yet they have attracted more attention because of their roles in disease...
  8. pmc Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs): Positive and negative regulators in tumor cell adhesion
    Dimitra Bourboulia
    Radiation Oncology Branch, Center for Cancer Research, NCI NIH, Advanced Technology Center, 8717 Grovemont Circle, Bethesda, MD 20892 4605, USA
    Semin Cancer Biol 20:161-8. 2010
    ..levels of adhesion molecules and/or due to elevated levels of secreted proteolytic enzymes, including matrix metalloproteinases (MMPs)...
  9. ncbi Matrix metalloproteinases in tumorigenesis: an evolving paradigm
    Hui Hua
    State Key Laboratory of Biotherapy, Section of Signal Transduction and Molecular Targeted Therapy, West China Hospital, Sichuan University, Chengdu
    Cell Mol Life Sci 68:3853-68. 2011
    Proteases are crucial for development, tissue remodeling, and tumorigenesis. Matrix metalloproteinases (MMPs) family, in particular, consists of more than 20 members with unique substrates and diverse function...
  10. ncbi Myocardial matrix remodeling and the matrix metalloproteinases: influence on cardiac form and function
    Francis G Spinale
    Division of Cardiothoracic Surgery, Medical University of South Carolina, Charleston, South Carolina 29403, USA
    Physiol Rev 87:1285-342. 2007
    ..Furthermore, a family of matrix proteases, the matrix metalloproteinases (MMPs) and the tissue inhibitors of MMPs (TIMPs), has been recognized to play an important role in ..
  11. ncbi Roles of matrix metalloproteinases in cancer progression and their pharmacological targeting
    Chrisostomi Gialeli
    Department of Chemistry, Laboratory of Biochemistry, University of Patras, Greece
    FEBS J 278:16-27. 2011
    b>Matrix metalloproteinases (MMPs) consist of a multigene family of zinc-dependent extracellular matrix (ECM) remodeling endopeptidases implicated in pathological processes, such as carcinogenesis...
  12. ncbi Matrix metalloproteinase-mediated disruption of tight junction proteins in cerebral vessels is reversed by synthetic matrix metalloproteinase inhibitor in focal ischemia in rat
    Yi Yang
    Department of Neurology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131 0001, USA
    J Cereb Blood Flow Metab 27:697-709. 2007
    b>Matrix metalloproteinases (MMPs) disrupt the blood-brain barrier (BBB) during reperfusion. Occludin and claudins are recently described tight junction proteins (TJPs) that form the BBB...
  13. ncbi Regulation of matrix metalloproteinases: an overview
    Sajal Chakraborti
    Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India
    Mol Cell Biochem 253:269-85. 2003
    b>Matrix metalloproteinases (MMPs) are a major group of enzymes that regulate cell-matrix composition. MMP genes show a highly conserved modular structure...
  14. ncbi Synaptic circuit remodelling by matrix metalloproteinases in health and disease
    George W Huntley
    Fishberg Department of Neuroscience, Friedman Brain Institute and the Graduate School of Biological Sciences, The Mount Sinai School of Medicine, New York, New York 10029, USA
    Nat Rev Neurosci 13:743-57. 2012
    b>Matrix metalloproteinases (MMPs) are extracellularly acting enzymes that have long been known to have deleterious roles in brain injury and disease...
  15. ncbi Strategies for MMP inhibition in cancer: innovations for the post-trial era
    Christopher Mark Overall
    Department of Oral Biological and Medical Sciences, C I H R Group in Matrix Dynamics, University of British Columbia, V6T 1Z3, Canada
    Nat Rev Cancer 2:657-72. 2002
    For more than two decades, the view that tumour-associated matrix metalloproteinases (MMPs) were required for peritumour tissue degradation and metastasis dominated the drive to develop MMP inhibitors as anticancer therapeutics...
  16. ncbi Matrix metalloproteinases as modulators of inflammation and innate immunity
    William C Parks
    University of Washington, Harborview Medical Center, Department of Medicine, Box 359640, 325 9th Avenue, Seattle, Washington 98104, USA
    Nat Rev Immunol 4:617-29. 2004
  17. ncbi Extracellular matrix remodelling: the role of matrix metalloproteinases
    Ivan Stamenkovic
    Experimental Pathology Division, Institut Universitaire de Pathologie, Universite de Lausanne, 25 Rue du Bagnon, CH 1011 Lausanne, Switzerland
    J Pathol 200:448-64. 2003
    b>Matrix metalloproteinases (MMPs) are a growing family of metalloendopeptidases that cleave the protein components of the extracellular matrix and thereby play a central role in tissue remodelling...
  18. ncbi Matrix metalloproteinases in neuroinflammation
    Gary A Rosenberg
    Departments of Neurology, Neurosciences, and Cell Biology and Physiology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131, USA
    Glia 39:279-91. 2002
    b>Matrix metalloproteinases (MMPs) are a gene family of neutral proteases that are important in normal development, wound healing, and a wide variety of pathological processes, including the spread of metastatic cancer cells, arthritic ..
  19. ncbi Series "matrix metalloproteinases in lung health and disease": Matrix metalloproteinases in COPD
    A Churg
    Dept of Pathology, University of British Columbia, 2211 Wesbrook Mall, Vancouver, BC V6T 2B5, Canada
    Eur Respir J 39:197-209. 2012
    There is considerable evidence that matrix metalloproteinases (MMPs) are up- and/or downregulated in chronic obstructive pulmonary disease (COPD), particularly in emphysema, in which they probably participate in proteolytic attack on the ..
  20. pmc Association between polymorphisms in the promoter regions of matrix metalloproteinases (MMPs) and risk of cancer metastasis: a meta-analysis
    Dan Liu
    Department of Medical Genetics, College of Basic Medical Sciences, Third Military Medical University, Chongqing, China
    PLoS ONE 7:e31251. 2012
    A variety of studies have evaluated the associations between polymorphisms in the promoter regions of Matrix metalloproteinases (MMPs) and cancer metastasis. However, the results remain inconclusive...
  21. pmc Matrix metalloproteinases: changing roles in tumor progression and metastasis
    Laurie A Shuman Moss
    Radiation Oncology Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    Am J Pathol 181:1895-9. 2012
    ..With time, the role of the extracellular matrix and matrix metalloproteinases in the regulation of tumor invasion, metastasis, and angiogenesis was recognized, and AJP has published ..
  22. ncbi The role of matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) in the development of esophageal cancer
    Magdalena Groblewska
    Department of Biochemical Diagnostics, Medical University of Bialystok, Waszyngtona Str 15a, 15 269 Bialystok, Poland
    Folia Histochem Cytobiol 50:12-9. 2012
    ..Etiologic factors and the patterns of incidence of both subtypes are different. Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) play an important role in esophageal carcinogenesis...
  23. ncbi Matrix metalloproteinases in vascular physiology and disease
    Suzanne A Siefert
    Center for Vascular and Inflammatory Diseases, Division of Vascular Surgery, Department of Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Vascular 20:210-6. 2012
    b>Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that primarily degrade components of the extracellular matrix (ECM)...
  24. ncbi IL-8 directly enhanced endothelial cell survival, proliferation, and matrix metalloproteinases production and regulated angiogenesis
    Aihua Li
    Department of Pathology and Microbiology, University of Nebraska Medical Center, 987660 Nebraska Medical Center, Omaha, NE 68198, USA
    J Immunol 170:3369-76. 2003
    ..by examining IL-8 receptor expression on endothelial cells and their proliferation, survival, and matrix metalloproteinases (MMPs) production...
  25. ncbi Zymographic techniques for the analysis of matrix metalloproteinases and their inhibitors
    Patricia A M Snoek-van Beurden
    University Medical Centre Nijmegen, Nijmegen, The Netherlands
    Biotechniques 38:73-83. 2005
    The balance between matrix metalloproteinases (MMPs) and their inhibitors, the tissue inhibitors of metalloproteinases (TIMPs), is largely responsible for the remodeling of tissues...
  26. pmc The many faces of metalloproteases: cell growth, invasion, angiogenesis and metastasis
    C Chang
    Department of Anatomy, Box 0452, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143-0452, USA
    Trends Cell Biol 11:S37-43. 2001
    ..We also discuss the evolving concept of how MMPs might regulate stem cell fate during tumor development...
  27. ncbi Matrix metalloproteinases in vascular remodeling and atherogenesis: the good, the bad, and the ugly
    Zorina S Galis
    Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA
    Circ Res 90:251-62. 2002
    ..extracellular matrix scaffold enables reshaping of tissue, participation of specialized enzymes called matrix metalloproteinases (MMPs) has become the object of intense recent interest in relation to physiological ("good") and ..
  28. pmc Regulation of matrix biology by matrix metalloproteinases
    Joni D Mott
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Curr Opin Cell Biol 16:558-64. 2004
    b>Matrix metalloproteinases (MMPs) are endopeptidases that contribute to growth, development and wound healing as well as to pathologies such as arthritis and cancer...
  29. pmc Progress in matrix metalloproteinase research
    Gillian Murphy
    Department of Oncology, University of Cambridge, Cancer Research UK Cambridge Research Institute, Cambridge, UK
    Mol Aspects Med 29:290-308. 2008
    b>Matrix metalloproteinases (MMPs) are now acknowledged as key players in the regulation of both cell-cell and cell-extracellular matrix interactions...
  30. ncbi Synergistic neovascularization by mixed transplantation of early endothelial progenitor cells and late outgrowth endothelial cells: the role of angiogenic cytokines and matrix metalloproteinases
    Chang Hwan Yoon
    Cardiovascular Laboratory, Clinical Research Institute, Seoul National University Hospital, Seoul, Korea
    Circulation 112:1618-27. 2005
    ..We also investigated whether the combination of these different cell types shows synergism during neovascularization...
  31. pmc Matrix metalloproteinases and their inhibitors in vascular remodeling and vascular disease
    Joseph D Raffetto
    Department of Surgery, VA Boston Healthcare System, West Roxbury, MA, United States
    Biochem Pharmacol 75:346-59. 2008
    b>Matrix metalloproteinases (MMPs) are a family of proteolytic enzymes that degrade various components of the extracellular matrix (ECM)...
  32. ncbi Metalloproteinase inhibitors: biological actions and therapeutic opportunities
    Andrew H Baker
    BHF Blood Pressure Group, Department of Medicine and Therapeutics, Western Infirmary, Glasgow G11 6NT, UK
    J Cell Sci 115:3719-27. 2002
    ....
  33. ncbi Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxygenation, angiopoietin-1, and matrix metalloproteinases
    Frank Winkler
    E L Steele Laboratory for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, 100 Blossom Street, Boston, MA 02114, USA
    Cancer Cell 6:553-63. 2004
    ..During the normalization window, but not before or after it, VEGFR2 blockade increases pericyte coverage of brain tumor vessels via upregulation of Ang1 and degrades their pathologically thick basement membrane via MMP activation...
  34. pmc Matrix metalloproteinases as novel biomarkers and potential therapeutic targets in human cancer
    Roopali Roy
    Program in Vascular Biology and Department of Surgery, Children s Hospital Boston and Harvard Medical School, Boston MA 02115, USA
    J Clin Oncol 27:5287-97. 2009
    ..This analysis includes a wide variety of human cancers and a number of human sample types including tissue, plasma, serum, and urine...
  35. ncbi Matrix metalloproteinases: contribution to pathogenesis, diagnosis and treatment of periodontal inflammation
    Timo Sorsa
    Department of Oral and Maxillofacial Diseases, Helsinki University Central Hospital HUCH, Institute of Dentistry, University of Helsinki, Helsinki, Finland
    Ann Med 38:306-21. 2006
    b>Matrix metalloproteinases (MMPs) form a family of enzymes that mediate multiple functions both in the tissue destruction and immune responses related to periodontal inflammation...
  36. ncbi Tumour microenvironment - opinion: validating matrix metalloproteinases as drug targets and anti-targets for cancer therapy
    Christopher M Overall
    University of British Columbia Centre for Blood Research, CBCRA Program in Breast Cancer Metastasis, Department of Oral Biological and Medical Sciences, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3
    Nat Rev Cancer 6:227-39. 2006
    The matrix metalloproteinases (MMPs) mediate homeostasis of the extracellular environment...
  37. ncbi Dual role of matrix metalloproteinases (matrixins) in intimal thickening and atherosclerotic plaque rupture
    Andrew C Newby
    Bristol Heart Institute, University of Bristol, United Kingdom
    Physiol Rev 85:1-31. 2005
    ..The matrix metalloproteinases (MMPs) can act together to degrade the major components of the vascular extracellular matrix...
  38. ncbi Matrix metalloproteinases: they're not just for matrix anymore!
    L J McCawley
    Department of Cancer Biology, Vanderbilt University Medical Center, 771 PRB, 23rd and Pierce, Nashville, Tennessee 37232-6840, USA
    Curr Opin Cell Biol 13:534-40. 2001
    The matrix metalloproteinases (MMPs) have been viewed as bulldozers, destroying the extracellular matrix to permit normal remodeling and contribute to pathological tissue destruction and tumor cell invasion...
  39. ncbi EMMPRIN/CD147, an MMP modulator in cancer, development and tissue repair
    Eric E Gabison
    Unité 532 Inserm, Hopital Saint Louis, Paris 75010, France
    Biochimie 87:361-8. 2005
    b>Matrix metalloproteinases (MMPs) play a central role in normal tissue remodeling and disease, they regulate tumor microenvironment and their expression is increased in most human cancers...
  40. ncbi Series "matrix metalloproteinases in lung health and disease": Biological role of matrix metalloproteinases: a critical balance
    S Löffek
    Dept of Dermatology, University Medical Center Freiburg, Freiburg, Germany
    Eur Respir J 38:191-208. 2011
    b>Matrix metalloproteinases (MMPs) are members of the metzincin group of proteases which share the conserved zinc-binding motif in their catalytic active site...
  41. ncbi Regulation of matrix metalloproteinase gene expression
    Chunhong Yan
    MD Anderson Cancer Center, University of Texas, Houston, Texas 77030, USA
    J Cell Physiol 211:19-26. 2007
    ..Finally, we argue for potential technologies to regulate MMP expression of utility in pathological conditions where these enzymes are aberrantly expressed...
  42. pmc MMPs and soluble ICAM-5 increase neuronal excitability within in vitro networks of hippocampal neurons
    Mark Niedringhaus
    Interdisciplinary Program in Neuroscience, Georgetown University Medical Center, Washington, District of Columbia, United States of America
    PLoS ONE 7:e42631. 2012
    b>Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases that are released from neurons in an activity dependent manner. Published studies suggest their activity is important to varied forms of learning and memory...
  43. ncbi Matrix metalloproteinases in cancer: their value as diagnostic and prognostic markers and therapeutic targets
    Elin Hadler-Olsen
    Department of Medical Biology, Faculty of Health Sciences, University of Tromsø, 9037, Tromsø, Norway
    Tumour Biol 34:2041-51. 2013
    ..In most cancers, there are increased levels of one or several members of the matrix metalloproteinases (MMPs)...
  44. ncbi Migration of bone marrow and cord blood mesenchymal stem cells in vitro is regulated by stromal-derived factor-1-CXCR4 and hepatocyte growth factor-c-met axes and involves matrix metalloproteinases
    Bo Ra Son
    Department of Medicine, University of Alberta, Edmonton, AB T6G 2R8, Canada
    Stem Cells 24:1254-64. 2006
    ..We also determined whether MSCs express matrix metalloproteinases (MMPs), including membrane type 1 (MT1)-MMP, matrix-degrading enzymes that facilitate the trafficking of ..
  45. ncbi Human matrix metalloproteinases: an ubiquitarian class of enzymes involved in several pathological processes
    Diego Sbardella
    Department of Experimental Medicine and Biochemical Sciences, University of Roma Tor Vergata, Roma, Italy
    Mol Aspects Med 33:119-208. 2012
    Human matrix metalloproteinases (MMPs) belong to the M10 family of the MA clan of endopeptidases...
  46. ncbi Matrix metalloproteinases in early diabetic retinopathy and their role in alteration of the blood-retinal barrier
    Stephen J Giebel
    Department of Cell Biology and Physiology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA
    Lab Invest 85:597-607. 2005
    ....
  47. ncbi Th17 cells, but not Th1 cells, from patients with early rheumatoid arthritis are potent inducers of matrix metalloproteinases and proinflammatory cytokines upon synovial fibroblast interaction, including autocrine interleukin-17A production
    J P van Hamburg
    Department of Rheumatology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    Arthritis Rheum 63:73-83. 2011
    ..The aim of this study was to identify and characterize the functional role of Th17 cells in early RA...
  48. ncbi Matrix metalloproteinases: protective roles in cancer
    Julie Decock
    School of Biological Sciences, University of East Anglia, Norwich, UK
    J Cell Mol Med 15:1254-65. 2011
    The original notion that matrix metalloproteinases (MMPs) act as tumour and metastasis-promoting enzymes by clearing a path for tumour cells to invade and metastasize has been challenged in the last decade...
  49. ncbi Matrix metalloproteinases and angiogenesis
    Joyce E Rundhaug
    Department of Carcinogenesis, Science Park Research Division, The University of Texas M D Anderson Cancer Center, Smithville, TX, 78957, USA
    J Cell Mol Med 9:267-85. 2005
    b>Matrix metalloproteinases (MMPs) are a family of enzymes that proteolytically degrade various components of the extracellular matrix (ECM)...
  50. ncbi Matrix metalloproteinases regulate migration, proliferation, and death of vascular smooth muscle cells by degrading matrix and non-matrix substrates
    Andrew C Newby
    University of Bristol, Bristol Heart Institute, Bristol Royal Infirmary, Bristol BS2 8HW, UK
    Cardiovasc Res 69:614-24. 2006
    ..We conclude that MMPs influence VSMC behaviour by cleaving both matrix and non-matrix substrates...
  51. ncbi MMPs in the eye: emerging roles for matrix metalloproteinases in ocular physiology
    Jeremy M Sivak
    Vision Research Laboratories, New England Eye Center, Tufts University School of Medicine, Center for Vision Research, Tufts University, 750 Washington Street, Box 450, 02111, Boston, MA 02111, USA
    Prog Retin Eye Res 21:1-14. 2002
    b>Matrix metalloproteinases (MMPs) are a family of proteolytic enzymes that function to maintain and remodel tissue architecture...
  52. ncbi Endothelial sprouting and angiogenesis: matrix metalloproteinases in the lead
    Victor W M van Hinsbergh
    Laboratory for Physiology, Institute for Cardiovascular Research, VU University Medical Center, Van der Boechorststraat 7, Amsterdam 1081 BT, The Netherlands
    Cardiovasc Res 78:203-12. 2008
    ..Better understanding of the various activities of proteases may be helpful in developing more specific inhibitors that could result in tailor-made modification of proteolytic activities in disease...
  53. ncbi Matrix metalloproteinases (MMPs) in health and disease: an overview
    Charles J Malemud
    Division of Rheumatic Diseases, Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
    Front Biosci 11:1696-701. 2006
    b>Matrix metalloproteinases (MMPs) are members of an enzyme family that require a zinc ion in their active site for catalytic activity. MMPs are critical for maintaining tissue allostasis...
  54. ncbi An alternate perspective on the roles of TIMPs and MMPs in pathology
    Craig S Moore
    Department of Neuroscience, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    Am J Pathol 180:12-6. 2012
    ..TIMPs are recognized as endogenous regulators of matrix metalloproteinases (MMPs), a large family of extracellular enzymes with proteolytic activities that participate in cellular ..
  55. ncbi Normal newt limb regeneration requires matrix metalloproteinase function
    Vladimir Vinarsky
    Division of Cardiology, Department of Internal Medicine, University of Utah, Salt Lake City, UT 84132, USA
    Dev Biol 279:86-98. 2005
    ..These data suggest that MMPs are required for normal newt limb regeneration and that MMPs function, in part, to prevent scar formation during the regenerative process...
  56. ncbi Alpha-synuclein activates microglia by inducing the expressions of matrix metalloproteinases and the subsequent activation of protease-activated receptor-1
    Eun Jung Lee
    Department of Molecular Medicine and Brain and Cognitive Sciences, Ewha Womans University, Korea
    J Immunol 185:615-23. 2010
    ..In our preliminary experiments, we found that alpha-synuclein induced the expression of matrix metalloproteinases (MMPs) (MMP-1, -3, -8, and -9) in rat primary cultured microglia...
  57. ncbi MT1-MMP: a potent modifier of pericellular microenvironment
    Yoshifumi Itoh
    Kennedy Institute of Rheumatology Division, Imperial College London, Hammersmith, London, United Kingdom
    J Cell Physiol 206:1-8. 2006
    ..Developing new means to inhibit "functional activity" of MT1-MMP may be a new direction to establish treatments for the diseases that MT1-MMP mediates such as cancer and rheumatoid arthritis...
  58. ncbi Mitochondrial redox control of matrix metalloproteinases
    Kristin K Nelson
    Center for Immunology and Microbial Disease, Albany Medical College, Albany, NY 12208, USA
    Free Radic Biol Med 37:768-84. 2004
    ..This review summarizes the evidence that implicates ROS as key regulators of MMP production and the importance of these interactions in disease pathologies...
  59. ncbi Interactions between extracellular matrix and growth factors in wound healing
    Gregory S Schultz
    Department of Obstetrics and Gynecology, University of Florida, Gainesville, 32610 0294, USA
    Wound Repair Regen 17:153-62. 2009
    ..Thus, the interactions between growth factors and ECM are bidirectional. This review explores these interactions, discusses how they are altered in difficult to heal or chronic wounds, and briefly considers treatment implications...
  60. pmc Matrix metalloproteinases contribute distinct roles in neuroendocrine prostate carcinogenesis, metastasis, and angiogenesis progression
    Laurie E Littlepage
    Department of Anatomy, University of California, San Francisco, California 94143 0452, USA
    Cancer Res 70:2224-34. 2010
    ..b>Matrix metalloproteinases (MMP), a family of enzymes that remodel the microenvironment, are associated with tumorigenesis and ..
  61. pmc Processing of VEGF-A by matrix metalloproteinases regulates bioavailability and vascular patterning in tumors
    Sunyoung Lee
    Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles 90095, USA
    J Cell Biol 169:681-91. 2005
    ..In this study, we demonstrate that VEGF bioavailability is regulated extracellularly by matrix metalloproteinases (MMPs) through intramolecular processing...
  62. ncbi Matrix metalloproteinases (MMPs): chemical-biological functions and (Q)SARs
    Rajeshwar P Verma
    Department of Chemistry, Pomona College, 645 North College Avenue, Claremont, CA 91711, USA
    Bioorg Med Chem 15:2223-68. 2007
    b>Matrix metalloproteinases (MMPs) are a large family of calcium-dependent zinc-containing endopeptidases, which are responsible for the tissue remodeling and degradation of the extracellular matrix (ECM), including collagens, elastins, ..
  63. ncbi Expression of matrix metalloproteinases, tissue inhibitors of metalloproteinases and vascular endothelial growth factor in canine mast cell tumours
    M Giantin
    Dipartimento di Biomedicina Comparata e Alimentazione, Universita degli Studi di Padova, Viale Universita 16, 35020 Legnaro, Padua, Italy
    J Comp Pathol 147:419-29. 2012
    ..b>Matrix metalloproteinases (MMPs), tissue inhibitors of metalloproteinases (TIMPs) and vascular endothelial growth factor-A (VEGF-A)..
  64. ncbi The other side of MMPs: protective roles in tumor progression
    Michelle D Martin
    Department of Cancer Biology, Vanderbilt University, 771 Preston Research Building, 23rd and Pierce Avenues, Nashville, TN 37232 6840, USA
    Cancer Metastasis Rev 26:717-24. 2007
    ..In order to effectively target MMPs in cancer progression, a better understanding of both their pro- and anti-tumorigenic effects is required...
  65. pmc Diverse roles of matrix metalloproteinases and tissue inhibitors of metalloproteinases in neuroinflammation and cerebral ischemia
    E Candelario-Jalil
    Department of Neurology, University of New Mexico Health Sciences Center, MSC10 5620, 1 University of New Mexico, Albuquerque, NM 87131 0001, USA
    Neuroscience 158:983-94. 2009
    ..b>Matrix metalloproteinases (MMPs) and the tissue inhibitors of metalloproteinases (TIMPs) are the major extracellular-degrading ..
  66. ncbi Matrix metalloproteinases and their tissue inhibitors in serum and cerebrospinal fluid of patients with amyotrophic lateral sclerosis
    I Niebroj-Dobosz
    Neuromuscular Unit, Medical Research Center, Polish Academy of Sciences, Warsaw, Poland
    Eur J Neurol 17:226-31. 2010
    b>Matrix metalloproteinases (MMPs) are implicated in the pathogenesis of motor neuron degeneration in amyotrophic lateral sclerosis (ALS)...
  67. ncbi Proteases in invasion: matrix metalloproteinases
    W G Stetler-Stevenson
    Laboratory of Pathology, Division of Clinical Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Semin Cancer Biol 11:143-52. 2001
    The role of proteases in general, and the matrix metalloproteinases in particular, in tumor invasion and metastasis is well established...
  68. pmc Role of matrix metalloproteinases and therapeutic benefits of their inhibition in spinal cord injury
    Haoqian Zhang
    Department of Neurosurgery, University of California, San Francisco, California 94143 0110, USA
    Neurotherapeutics 8:206-20. 2011
    This review will focus on matrix metalloproteinases (MMPs) and their inhibitors in the context of spinal cord injury (SCI). MMPs have a specific cellular and temporal pattern of expression in the injured spinal cord...
  69. pmc Expression of matrix metalloproteinases subsequent to urogenital Chlamydia muridarum infection of mice
    K H Ramsey
    Department of Microbiology and Immunology, Chicago College of Osteopathic Medicine, Midwestern University, IL 60516, USA
    Infect Immun 73:6962-73. 2005
    The central hypothesis of this study was that matrix metalloproteinases (MMPs) would be enhanced following murine chlamydial infection and that their expression would vary in mouse strains that differ in their susceptibility to chronic ..
  70. ncbi Elevated plasma matrix metalloproteinases and their tissue inhibitors in patients with severe sepsis
    Payam Yazdan-Ashoori
    Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada
    J Crit Care 26:556-65. 2011
    b>Matrix metalloproteinases (MMPs) are essential for tissue remodeling...
  71. pmc Matrix metalloproteinases, the pros and cons, in liver fibrosis
    Yuan Ping Han
    Department of Surgery and Pathology, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA
    J Gastroenterol Hepatol 21:S88-91. 2006
    ..Indeed, matrix metalloproteinases (MMP), a family of ECM degradative enzymes, are promptly expressed by HSC in response to diverse hepatic ..
  72. pmc Reversal of West Nile virus-induced blood-brain barrier disruption and tight junction proteins degradation by matrix metalloproteinases inhibitor
    Saguna Verma
    Retrovirology Research Laboratory, Department of Tropical Medicine, Medical Microbiology and Pharmacology, John A Burns School of Medicine, Honolulu, HI 96813, USA
    Virology 397:130-8. 2010
    ..We characterized the expression of matrix metalloproteinases (MMP) in WNV-infected human brain microvascular endothelial cells (HBMVE) and human brain cortical ..
  73. ncbi Caveolin-1 regulates nitric oxide-mediated matrix metalloproteinases activity and blood-brain barrier permeability in focal cerebral ischemia and reperfusion injury
    Yong Gu
    School of Chinese Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    J Neurochem 120:147-56. 2012
    ..The present study aims to address whether the loss of cav-1 impacts on BBB permeability and matrix metalloproteinases (MMPs) activity during cerebral ischemia-reperfusion injury...
  74. ncbi Targeting leukocyte MMPs and transmigration: minocycline as a potential therapy for multiple sclerosis
    Veronika Brundula
    Department of Clinical Neurosciences, University of Calgary, Canada
    Brain 125:1297-308. 2002
    Multiple sclerosis is characterized by the infiltration of leukocytes into the CNS. As matrix metalloproteinases (MMPs) facilitate the passage of leukocytes across matrix barriers, we tested the hypothesis that targeting MMPs could ..
  75. ncbi Determination of protease cleavage site motifs using mixture-based oriented peptide libraries
    B E Turk
    Department of Medicine, Beth Israel Deaconess Medical Center, Department of Cell Biology, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    Nat Biotechnol 19:661-7. 2001
    ..Our results indicate that a small set of libraries can be used to quickly profile an expanding protease family, providing information applicable to the design of inhibitors and to the identification of protein substrates...
  76. pmc Mechanistic modeling of the effects of myoferlin on tumor cell invasion
    Marisa C Eisenberg
    Mathematical Biosciences Institute, Ohio State University, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 108:20078-83. 2011
    ..The mathematical model predictions revealed that matrix metalloproteinases (MMPs) may play a key role in modulating this invasive property, which was supported by experimental ..
  77. ncbi Matrix metalloproteinases as therapeutic targets in protozoan parasitic infections
    Nathalie Geurts
    Laboratory of Immunobiology, Rega Institute for Medical Research, University of Leuven, Leuven, Minderbroedersstraat 10, B3000 Leuven, Belgium
    Pharmacol Ther 133:257-79. 2012
    b>Matrix metalloproteinases (MMPs) are associated with processes of tissue remodeling and are expressed in all infections with protozoan parasites...
  78. ncbi Hypoxia, tumour-associated macrophages, microvessel density, VEGF and matrix metalloproteinases in human gastric cancer: interaction and impact on survival
    Sergej Osinsky
    Department of Microenvironment of Tumor Cells, R E Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, National Academy of Sciences of Ukraine, Kiev, Ukraine
    Clin Transl Oncol 13:133-8. 2011
    ..Our study was aimed to evaluate the impact of hypoxia and hypoxia-associated factors on tumour progression and survival of patients with gastric cancer...
  79. pmc Matrix metalloproteinases are modifiers of huntingtin proteolysis and toxicity in Huntington's disease
    John P Miller
    Buck Institute for Age Research, Novato, CA 94945, USA
    Neuron 67:199-212. 2010
    ..Correspondingly, MMPs are activated in HD mouse models, and loss of function of Drosophila homologs of MMPs suppresses Htt-induced neuronal dysfunction in vivo...
  80. pmc Tumor cell and carcinoma-associated fibroblast interaction regulates matrix metalloproteinases and their inhibitors in oral squamous cell carcinoma
    Alexandra Fullár
    1st Department of Pathology and Experimental Cancer Research, Semmelweis University, Ulloi ut 26, 1085 Budapest, Hungary
    Exp Cell Res 318:1517-27. 2012
    ..The crosstalk between cancer- and the surrounding fibroblast stromal-cells is essential for the fine tuning of cancer cells invasivity...
  81. ncbi Matrix metalloproteinases are differentially expressed in adipose tissue during obesity and modulate adipocyte differentiation
    Carine Chavey
    INSERM, Unité 145, Institut Fédératif de Recherche IFR 50, 06107 Nice, France
    J Biol Chem 278:11888-96. 2003
    b>Matrix metalloproteinases (MMPs) are essential for proper extracellular matrix remodeling, a process that takes place during obesity-mediated adipose tissue formation...
  82. ncbi Matrix metalloproteinases in tuberculosis
    P T Elkington
    Department of Infectious Diseases and Immunity, Imperial College London, Hammersmith Campus, Du Cane Road, London, W12 0NN, UK
    Eur Respir J 38:456-64. 2011
    ..in TB remain poorly understood but consideration of the lung extracellular matrix predicts that matrix metalloproteinases (MMPs) will play a central role, owing to their unique ability to degrade fibrillar collagens and other ..
  83. ncbi Matrix metalloproteinase activity inactivates the CXC chemokine stromal cell-derived factor-1
    G A McQuibban
    Department of Biochemistry and Molecular Biology, Oral Biological and Medical Sciences, Biomedical Research Centre, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
    J Biol Chem 276:43503-8. 2001
    ..Recently we reported that matrix metalloproteinases (MMPs) modulate the activity of the CC chemokine monocyte chemoattractant protein-3 by selective ..
  84. ncbi The TIMPs tango with MMPs and more in the central nervous system
    Stephen J Crocker
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Neurosci Res 75:1-11. 2004
    The matrix metalloproteinases (MMPs) are a family of zinc-dependent extracellular proteases that have been implicated in CNS development and disease...
  85. ncbi Protease degradomics: mass spectrometry discovery of protease substrates and the CLIP-CHIP, a dedicated DNA microarray of all human proteases and inhibitors
    Christopher M Overall
    Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
    Biol Chem 385:493-504. 2004
    ..b>Matrix metalloproteinases (MMPs) showed a restricted expression pattern in both normal and cancerous breast tissues with most ..
  86. ncbi A highly specific inhibitor of matrix metalloproteinase-9 rescues laminin from proteolysis and neurons from apoptosis in transient focal cerebral ischemia
    Zezong Gu
    Center for Neuroscience and Aging, The Burnham Institute, La Jolla, California 92037, USA
    J Neurosci 25:6401-8. 2005
    ..The aberrant, excessive activity of matrix metalloproteinases (MMPs), especially MMP-9, contributes directly to neuron apoptosis and brain damage (Rosenberg et al...
  87. pmc Differential expression of matrix metalloproteinases and their tissue inhibitors in colon mucosa of patients with inflammatory bowel disease
    B von Lampe
    Medizinische Klinik I Gastroenterologie und Infektiologie, Klinikum Benjamin Franklin, FU Berlin, Hindenburgdamm 30, 12200 Berlin, FRG
    Gut 47:63-73. 2000
    ..Degradation of collagens is highly regulated by a cascade of matrix metalloproteinases (MMPs)...
  88. ncbi Enhanced invasiveness of breast cancer cell lines upon co-cultivation with macrophages is due to TNF-alpha dependent up-regulation of matrix metalloproteases
    Thorsten Hagemann
    Department of Haematology Oncology, Georg August University, Gottingen, Germany
    Carcinogenesis 25:1543-9. 2004
    ..In summary, we have found that co-cultivation of tumour cells with macrophages leads to enhanced invasiveness of the malignant cells due to TNF-alpha dependent MMP induction in the macrophages...
  89. ncbi TIMP-2 mediated inhibition of angiogenesis: an MMP-independent mechanism
    Dong Wan Seo
    National Cancer Institute, Center for Cancer Research, Vascular Biology Faculty and Laboratory of Pathology, Extracellular Matrix Pathology Section, National Institutes of Health, Bethesda, MD 20892, USA
    Cell 114:171-80. 2003
    ..Our findings establish an unexpected, MMP-independent mechanism for TIMP-2 inhibition of endothelial cell proliferation in vitro and reveal an important component of the antiangiogenic effect of TIMP2 in vivo...
  90. ncbi Matrix metalloproteinases involvement in pathologic conditions
    Cornelia Amalinei
    Department of Normal and Pathological Morphology, Faculty of Medicine, Grigore T Popa University of Medicine and Pharmacy, Iassy, Romania
    Rom J Morphol Embryol 51:215-28. 2010
    b>Matrix metalloproteinases (MMPs) have a great variability that provides a complex intervention in pathophysiological conditions...
  91. ncbi The role of matrix metalloproteinase polymorphisms in the rate of decline in lung function
    Ladina Joos
    University of British Columbia McDonald Research Laboratories iCAPTURE Center, St Paul s Hospital, 1081 Burrard Street, Vancouver, British Columbia V6Z 1Y6, Canada
    Hum Mol Genet 11:569-76. 2002
    The matrix metalloproteinases (MMPs) comprise a family of at least 20 proteolytic enzymes that play an essential role in tissue remodeling...
  92. ncbi Matrix metalloproteinases in cancer
    Yoshifumi Itoh
    Kennedy Institute of Rheumatology, Faculty of Medicine, Imperial College of Science, Technology and Medicine, 1 Aspenlea Road, Hammersmith, London W6 8LH, U K
    Essays Biochem 38:21-36. 2002
    ..The key enzymes responsible for ECM breakdown are matrix metalloproteinases (MMPs). To date, 23 MMP genes have been identified in humans and many are implicated in cancer...
  93. ncbi Matrix metalloproteinases stimulate epithelial-mesenchymal transition during tumor development
    Lidiya S Orlichenko
    Mayo Clinic Cancer Center, Jacksonville, FL 32224, USA
    Clin Exp Metastasis 25:593-600. 2008
    b>Matrix metalloproteinases (MMPs) are a family of more than 28 enzymes that were initially identified on the basis of their ability to cleave most elements of the extracellular matrix (ECM) but have subsequently been found to be ..
  94. ncbi Updated biological roles for matrix metalloproteinases and new "intracellular" substrates revealed by degradomics
    Georgina S Butler
    Centre for Blood Research, Department of Oral Biological and Medical Sciences, University of British Columbia, Vancouver, BC, Canada
    Biochemistry 48:10830-45. 2009
    ..by genomic and proteomic techniques, have exponentially expanded the known substrate repertoire of the matrix metalloproteinases (MMPs), even to include intracellular proteins with newly recognized extracellular functions...
  95. ncbi Role of matrix metalloproteinases (MMPs) in colorectal cancer
    Stanley Zucker
    Veterans Affairs Medical Center, Northport, NY 11768, USA
    Cancer Metastasis Rev 23:101-17. 2004
    Considerable evidence has implicated matrix metalloproteinases (MMPs), a group of zinc-dependent endopeptidases, in the degradation of extracellular matrix (ECM) during the metastatic process...
  96. ncbi Matrix metalloproteinases: roles in cancer and metastasis
    Barbara Fingleton
    Dept of Cancer Biology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Front Biosci 11:479-91. 2006
    ..The aim of this article is to summarize recent findings in these areas and put them in the context of our growing understanding of how MMPs function in cancer development and progression...
  97. ncbi Matrix metalloproteinases in brain development and remodeling: synaptic functions and targets
    Iryna M Ethell
    Division of Biomedical Sciences, University of California Riverside, Riverside, California 92521 0121, USA
    J Neurosci Res 85:2813-23. 2007
    b>Matrix metalloproteinases (MMPs) play critical roles in egg fertilization, embryonic development, wound repair, cancer, and inflammatory and neurologic diseases...
  98. pmc The paradox of matrix metalloproteinases in infectious disease
    P T G Elkington
    Department of Infectious Diseases, Hammersmith Campus, Imperial College, London, UK
    Clin Exp Immunol 142:12-20. 2005
    b>Matrix metalloproteinases (MMPs) are a family of proteolytic enzymes that perform multiple roles in the normal immune response to infection...
  99. ncbi Proanthocyanidins from grape seeds inhibit expression of matrix metalloproteinases in human prostate carcinoma cells, which is associated with the inhibition of activation of MAPK and NF kappa B
    Praveen K Vayalil
    Department of Dermatology, University of Alabama at Birmingham, 35294, USA
    Carcinogenesis 25:987-95. 2004
    ..The recognition that matrix metalloproteinases (MMPs) facilitate tumor cell invasion and metastasis of PCA has led to the development of MMP inhibitors ..
  100. pmc Molecular insights and therapeutic targets for blood-brain barrier disruption in ischemic stroke: critical role of matrix metalloproteinases and tissue-type plasminogen activator
    Rong Jin
    Department of Neurosurgery, LSU Health Science Center, Shreveport, LA 71130, USA
    Neurobiol Dis 38:376-85. 2010
    Blood-brain barrier (BBB) disruption, mediated through matrix metalloproteinases (MMPs) and other mechanisms, is a critical event during ischemic stroke...
  101. ncbi Smooth muscle cell matrix metalloproteinases in idiopathic pulmonary arterial hypertension
    H Lepetit
    INSERM U492, Dept de Physiologie, Faculte de Medecine, CHU Henri Mondor Créteil, 94010 Creteil, France
    Eur Respir J 25:834-42. 2005
    ..b>Matrix metalloproteinases (MMPs) are matrix-degrading enzymes involved in ECM turnover, and in smooth muscle cell (SMC) and ..

Research Grants75

  1. Anti-Inflammatory Glycosaminoglycan Ethers for Treatment of Periodontitis
    JUSTIN RODNEY SAVAGE; Fiscal Year: 2013
    ..gingivalis lipopolysaccharide (LPS)-stimulated IL-1[unreadable], prostaglandin E2, and matrix metalloproteinases (MMP) 1, 2, 3, and 9 release from macrophages and human gingival fibroblasts...
  2. The effect of trichloroethylene exposure on adverse pregnancy outcomes
    Iman Hassan; Fiscal Year: 2013
    ..cytokine release and increased expression of prostaglandin-endoperoxide synthase 2 (PTGS2), matrix metalloproteinases (MMPs) and redox- sensitive genes in human placental trophoblasts (HTR-8/SVneo cell line)...
  3. Role of Inflammation in the Pathobiology of Abdominal Aortic Aneurysm
    KATHLEEN RAMAN; Fiscal Year: 2013
    ..is related to increased elaboration and activity of elastin-specific proteinases, particularly matrix metalloproteinases (MMPs)...
  4. Treatment of stroke with a clinically approved proteasome inhibitor
    Li Zhang; Fiscal Year: 2012
    ..eNOS mediates the neuroprotective effect of VELCADE by down-regulation of pro- coagulation genes and matrix metalloproteinases (MMPs), which provoke thrombosis, and BBB damage...
  5. Elucidating the JNK2-mediated redox regulation of cartilage matrix remdeling
    ELIZABETH ALICE ERICKSON; Fiscal Year: 2010
    ..and cytokine signaling pathways which stimulate chondrocyte production of ECM degrading enzymes called matrix metalloproteinases (MMPs)...
  6. Cardiac dysfunction in StrepTSS: interplay of SLO and MMPs
    Dennis L Stevens; Fiscal Year: 2013
    ..b>Matrix metalloproteinases (MMP) are a family of zinc-requiring enzymes that break down structural proteins such as collagen in ..
  7. Opioidergic System: Its Role(s) in Glaucoma
    Shahid Husain; Fiscal Year: 2013
    ..progressive optic neuropathy, serving as the cellular source of multifunctional cytokines and enzymes (matrix metalloproteinases [MMPs]) responsible for remodeling the extracellular matrix within the optic nerve head...
  8. Multiple Molecular Mechanisms for Adiponectin Therapy in Hepatic Fibrogenesis
    Frank A Anania; Fiscal Year: 2013
    ..protein 1 (AP-1) is the mechanism responsible for adiponectin's transcriptional activation of matrix metalloproteinases (MMPs) MMP-1/13;and, for inhibiting ?(I) collagen gene transcription through deactivation of FAK...
  9. Distinct roles of CARP target genes in wound healing
    Karinna Almodóvar; Fiscal Year: 2013
    ..The proposed research will investigate the regulation of integrins and matrix metalloproteinases by the transcriptional nuclear co-factor, CARP...
  10. MECHANISMS OF CHONDROPROTECTION BY POMEGRANATE FRUIT EXTRACT
    Tariq M Haqqi; Fiscal Year: 2011
    ..a potent inhibitory effect on IL-IB-induced activation of p38-MAPK and JNK, NF-kB and expression of matrix metalloproteinases (MMPs) by human cartilage explants and chondrocytes in vitro...
  11. Protein Acetylation in Glaucomatous Optic Neuropathy
    Craig E Crosson; Fiscal Year: 2013
    ..secretion of TNF-[unreadable] from the optic nerve tissue, and block the cytokine-induced expression of matrix metalloproteinases (MMPs)...
  12. Cu,Zn-SOD, MMP-9, and Asbestosis
    A Brent Carter; Fiscal Year: 2013
    ..An emerging target for signaling molecules, such as H2O2, are the family of matrix metalloproteinases (MMPs) which regulate the fibrotic phenotype...
  13. Molecular Determinants of Tumor Progression in A Steatolic Liver Microenvironment
    Harold L Moses; Fiscal Year: 2013
    ..Microarray analysis indicates that the matrix metalloproteinases MMP12 and MMP13 are markedly elevated in the steatotic microenvironment, leading to the hypothesis that ..
  14. Heat shock proteins in brain ischemia and stroke
    Midori A Yenari; Fiscal Year: 2013
    ..Recent work in the field has implicated matrix metalloproteinases (MMPs), a family of Zn-dependent endopeptidases, in the breakdown of the extracellular matrix and BBB ..
  15. Role of serum amyloid A in interferon-gamma expression and T helper 1 cell differ
    Rong Lucy He; Fiscal Year: 2013
    ..activities and stimulates the secretion of pro-inflammatory factors such as IL-8, TNF1, IL-12, IL-6, matrix metalloproteinases and tissue factors, which, in turn, established SAA as a key inflammatory mediator in the innate immune ..
  16. HS1 Function in Dendritic Cells
    Janis K Burkhardt; Fiscal Year: 2011
    ..and podosome dynamics in migrating BMDCs using video microscopy, ask if HS1 is required for secretion of matrix metalloproteinases, and test the ability of HS1-/- DCs to migrate to lymph nodes in vivo...
  17. Oxidant Stress Mechanisms in Preeclampsia
    Scott W Walsh; Fiscal Year: 2013
    ..NF-?B and COX-2 (hallmarks of inflammation), myeloperoxidase (a potent oxidizing enzyme), and matrix metalloproteinases 1 and 8...
  18. c-Abl-mediated Suppression of Breast Cancer Development and Metastasis
    WILLIAM SCHIEMANN; Fiscal Year: 2013
    ..transition programs coupled to elevated p21 expression, and to diminished expression of matrix metalloproteinases. Along these lines, we recently observed TNBC tumorigenicity to be inversely related to c-Abl expression ..
  19. Growth and Carcinogenic Potential in the Postnatal Mammary Gland
    Demetri D Spyropoulos; Fiscal Year: 2010
    ..In the latter case, we also observed downregulation of matrix metalloproteinases (MMPs) and upregulation of inhibitors of MMPs, indicating IGFBP3 stabilization...
  20. Impact of Pregnancy on Drug Absorption, Disposition and End Organ Response
    Steve N Caritis; Fiscal Year: 2013
    ..impact of these agents on cervicovaginal fluid biomarkers including cervical length and density, matrix metalloproteinases, cytokines, and the cervicovaginal proteome...
  21. Matrix and trophic coupling in the neurovascular unit
    Eng H Lo; Fiscal Year: 2011
    ..g. matrix metalloproteinases, MMPs) decouple these growth factor signals in the neurovascular unit...
  22. Invasive Behavior of Tumor Cells Producing Collagenase-1
    Constance E Brinckerhoff; Fiscal Year: 2013
    ..Destruction of the extracellular matrix in tumor invasion and metastasis is mediated primarily by Matrix Metalloproteinases (MMPs), a family of enzymes that are over-expressed in many cancers...
  23. Transforming Growth Factor-beta Signaling Pathways in Thoracic Aortic Aneurysms
    Jeffrey A Jones; Fiscal Year: 2013
    ..remodeling is a result of a significant spatiotemporal change in the expression/abundance of the matrix metalloproteinases and their endogenous tissue inhibitors, little attention has been focused on the upstream signaling ..
  24. Mitochondrial Matrix Metalloproteinase-2 and Cardiac Injury
    David H Lovett; Fiscal Year: 2013
    ..Matrix Metalloproteinase-2 and Cardiac Injury Modulation of cardiac structure and function by matrix metalloproteinases (MMP) has become an area of intense interest...
  25. Matricellular Proteins in Trabecular Meshwork Increase Intraocular Pressure
    Douglas J Rhee; Fiscal Year: 2013
    ..overexpression increases collagen IV, laminin, and fibronectin production and shifts the balance of matrix metalloproteinases and tissue inhibitors of metalloproteinases towards greater ECM deposition...
  26. Exploiting Protease-Activatable Agents to Characterize and Treat Asthma
    Csilla Felsen; Fiscal Year: 2013
    ..The secreted proteases include elastase, chymase, ADAM33, and matrix metalloproteinases (MMPs) like MMP2/9/12...
  27. EphB signaling in dendritic spine development
    Iryna M Ethell; Fiscal Year: 2013
    ..in synapses is also important for the stabilization of mature dendritic spines and can be regulated by matrix metalloproteinases (MMPs)...
  28. Matrix Metalloproteinases and Spinal Cord Injury
    Linda J Noble; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: Matrix metalloproteinases constitute a large family of proteins with diverse biologic functions in normal, diseased, and injured ..
  29. Protease regulation of ovarian recrudescence
    KELLY ANSLEY YOUNG; Fiscal Year: 2013
    ..tissue remodeling events, many of which are associated with a family of Zn+dependent endopeptidases, the matrix metalloproteinases (MMPs)...
  30. Zeiss 2-photon (2P) LSM780 laser scanning confocal microscope
    Moshe Levi; Fiscal Year: 2013
    ..In contrast in advanced atherosclerosis activation of tissue matrix metalloproteinases can result in localized decreased in matrix proteins...
  31. MMPs, Integrins and Microglial activation in HAND
    KATHLEEN ANNE MAGUIRE-ZEISS; Fiscal Year: 2013
    ..Emerging evidence suggests that matrix metalloproteinases (MMPs) could play a critical role in stimulating such activation...
  32. Pyruvate: Powerful Brain Protection after Cardiac Arrest
    Robert T Mallet; Fiscal Year: 2013
    ..kinase activation, neutrophil infiltration, and activities of proapoptotic caspases, pro-inflammatory matrix metalloproteinases, and the cytoprotective enzyme endothelial nitric oxide synthase will be measured in vulnerable brain ..
  33. Engineering Polymers For Gene Therapy of Head Cancer
    Hamid Ghandehari; Fiscal Year: 2013
    ..b>Matrix metalloproteinases (MMPs) are known to degrade and remodel the tumor extracellular matrix...
  34. Matrix Metalloproteinase Inhibitors in Stroke
    GARY ALLEN ROSENBERG; Fiscal Year: 2010
    ..Prevention of the BBB damage expands the therapeutic window for the use of rtPA in stroke. Matrix metalloproteinases (MMPs) are increased in brain after hypoxic/ischemic injury: MMPs disrupt the blood-brain barrier (BBB), ..
  35. Modulation of the Epithelial Sodium Channel by Proteases and Peptide Inhibitors
    CHRISTOPHER JOHN PASSERO; Fiscal Year: 2010
    ..Recent evidence suggests plasmin and matrix metalloproteinases activate ENaC...
  36. Matrix Metalloproteinases in Hepatic Ischemia and Reperfusion Injury
    Ana J Coito; Fiscal Year: 2013
    ..We expect that our proposed work will lead to critical insights on the individual functions of key matrix metalloproteinases (MMPs), leading to the development of novel therapeutic manipulations that, by reducing the detrimental ..
  37. A novel function of TIMP-1
    Hyeong Reh Choi Kim; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: Tissue inhibitor of metalloproteinases (TIMP)-1, a natural inhibitor of matrix metalloproteinases (MPs), has been shown to inhibit tumor cell invasion in vitro and tumor progression in animal models of ..
  38. Effects of mechanical forces on lung injury and repair
    Bela Suki; Fiscal Year: 2010
    ..and type II alveolar epithelial (type II) cells to secrete collagen remodeling enzymes such as the matrix metalloproteinases, MMP-1 and MMP-2...
  39. QD-BRET nanosensors for protease detection and imaging
    Jianghong Rao; Fiscal Year: 2012
    ..This migration progress is believed to be assisted by a family of hydrolytic enzymes including matrix metalloproteinases (MMPs)...
  40. Cyclophilin-CD147 interaction in autoimmune arthritis
    Stephanie L Constant; Fiscal Year: 2010
    ..Our studies identified CD147, previously characterized as an inducer of extracellular matrix metalloproteinases (MMPs), as a cell surface receptor for extracellular cyclophilins...
  41. New Strategies and Screening Methods for Metalloproteinase Inhibition
    Seth M Cohen; Fiscal Year: 2010
    ..b>Matrix metalloproteinases (MMPs) play a central role in the progression of inflammatory disease, stroke, arthritis, cancer, and ..
  42. Age-Dependent Mechanisms in Thoracic Aortic Aneurysms
    John S Ikonomidis; Fiscal Year: 2013
    ..The matrix metalloproteinases (MMPs) are a family of proteolytic enzymes that play an obligate role in TAA-induced ECM remodeling...
  43. Biomarkers of Vasospasm and Outcome following Subarachnoid Hemorrhage
    Sherry Hsiang Yi Chou; Fiscal Year: 2013
    ..to examine the relationship between vasospasm seen on angiogram with white blood cells'release of matrix metalloproteinases (MMPs) which can cleave endothelin-1 into fragments that can subsequently cause spasm of cerebral ..
  44. Extracellular Matrix Metabolism in Thoracic Aortic Aneurysm and Dissection
    Scott A LeMaire; Fiscal Year: 2011
    ..We will regenerate TAAD by local CaCl2 challenge, which activates matrix metalloproteinases (MMPs) and causes aortic aneurysms...
  45. Host MMP-mediated regulation of the vicious cycle of prostate to bone metastases
    Conor C Lynch; Fiscal Year: 2013
    ..expression of thousands of genes in prostate bone tumors and have found that several enzymes known as matrix metalloproteinases (MMPs) are present at high levels (MMP-2, MMP-3, MMP-7, MMP-9 and MMP-13) and that they are ..
  46. The Role of Biglycan in Reproduction
    BEATRICE ELIZABETH LECHNER; Fiscal Year: 2013
    ..This syndrome is associated with an increased incidence of PPROM. Furthermore, matrix metalloproteinases, enzymes which are involved in degradation of the extracellular matrix and which have been implicated in ..
  47. Mechano-Sensitive Hypoxia-Inducible Factor-MMP Pathway in Venous Insufficiency
    Raouf A Khalil; Fiscal Year: 2013
    ..Also, the plasma and venous tissue levels of matrix metalloproteinases (MMPs) are elevated in CVI, suggesting a role for MMPs in vein dilation...
  48. MOLECULAR ASPECTS OF ALPORT RENAL DISEASE PROGRESSION
    DOMINIC E COSGROVE; Fiscal Year: 2013
    ..We and others have published definitive works which point to a key role for dysregulation of matrix metalloproteinases (MMPs) as an underlying cause of Alport GBM pathology...
  49. Arterial Remodeling in Chronic Liver Diseases
    Yasuko Iwakiri; Fiscal Year: 2013
    ..inducer, plays an important role in vascular remodeling and tumor invasion, by inducing activation of matrix metalloproteinases (MMPs), such as MMP-2...
  50. Matrix Metalloproteinase Regulation of Leukocyte Infiltration during Wound Repair
    LISA JOY MCCAWLEY; Fiscal Year: 2013
    ..An essential part of wound healing is inflammation. Matrix Metalloproteinases such as MMP3 may play a key role in regulating inflammation during wound healing.
  51. Molecular Imaging of Protease Activation in Aneurysm
    Mehran M Sadeghi; Fiscal Year: 2013
    ..b>Matrix metalloproteinases (MMPs) play a key role in the pathogenesis of aortic aneurysm and its major complications, rupture and ..
  52. Matrix Metalloproteinases in Hepatic Ischemia and Reperfusion Injury
    Ana J Coito; Fiscal Year: 2010
    ..Moreover, we will assess the function of Timp-1 overexpression as a therapeutic approach in partial liver IRI and in steatotic OLT. ..
  53. Endothelial Myocyte Matrix in Cardiac Remodeling
    Suresh C Tyagi; Fiscal Year: 2013
    ..with increased oxidized-matrix accumulation (fibrosis), activation of latent resident myocardial matrix metalloproteinases (MMPs) and inactivation of cardiac tissue inhibitor of metalloproteinase (TIMP-4) secondary to oxidative ..
  54. A collagen wound dressing augmented with a proteoglycan mimic to enhance chronic
    Kate Stuart; Fiscal Year: 2013
    ..Chronic wounds have a high level of inflammatory activity, specifically matrix metalloproteinases (MMPs) that leads to high turnover of the extracellular matrix in a chronic wound...
  55. Exosites in Matrix Metalloproteinase Localization and Activity
    Steven R Van Doren; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Tissue- and cell-specific sites of action of matrix metalloproteinases (MMPs) have recently been identified...
  56. Mechanisms of abdominal aortic aneurysm formation
    Alan Daugherty; Fiscal Year: 2010
    ..de Beer) will determine the role of serum amyloid A and its interaction with selected matrix metalloproteinases. Project 4 (Nancy R...
  57. PAR-1 Signaling and HAND
    KATHLEEN ANNE MAGUIRE-ZEISS; Fiscal Year: 2013
    ..Levels of PAR-1 activators, including plasmin and matrix metalloproteinases (MMPs), are substantially increased in HIV associated neurological disorders (HAND) and one study has ..
  58. The Role of JAB1 in osteosarcoma pathogenesis
    Guang Zhou; Fiscal Year: 2013
    ..skeletal dysplasia, accompanied by the drastically decreased expression of tumor-promoting factors matrix metalloproteinases (MMPs)...
  59. The role of interleukin-18 in myocardial hypertrophy and failure
    Bysani Chandrasekar; Fiscal Year: 2013
    ..remodeling through the induction of hypertrophy-associated kinases, fetal genes, growth factors, and matrix metalloproteinases. To address this HYPOTHESIS, we will investigate IL-18-dependent signaling in cardiomyocytes in vitro (..
  60. Smad3 inhibitors for ophthalmic applications
    Ching Yuan; Fiscal Year: 2010
    ..We will first investigate the expression of collagens, matrix metalloproteinases and keratoepithelin under Smad3 inhibitor treatment on corneal explant cultures...
  61. M. Tuberculosis Influences Host Matrix Metalloproteinases and Granuloma Formation
    NICOLE AMMERMAN; Fiscal Year: 2013
    ..cAMP affects host cell signaling events involved in the production and secretion of matrix metalloproteinases (MMPs)...
  62. Peripheral Blood Biomarkers of RA-associated Interstitial Lung Disease
    Dana P Ascherman; Fiscal Year: 2013
    ..Based on the hypothesis that CXCR3-binding chemokines and various matrix metalloproteinases play a significant role in driving inflammation as well as tissue damage in RA-ILD, Specific Aim 1 ..
  63. UV-induced collagen reduction: treating skin scleroderma
    Sewon Kang; Fiscal Year: 2005
    ..This reduction occurs through two simultaneous mechanisms; 1) induction of matrix metalloproteinases (MMP) that degrade skin collagen, and 2) inhibit of new procollagen synthesis...
  64. 92K-GL (MMP 9) AND THE INVASIVE PHENOTYPE
    MARTIN BODDEN; Fiscal Year: 1999
    ..92K-GL is a member of the family of matrix metalloproteinases (MMP), a homologous group of 10 zinc dependent endopeptidases which collectively cleave most components ..
  65. UTERINE BIOLOGY AND THE PATHOPHYSIOLOGY OF ENDOMETRIOSIS
    Kevin Osteen; Fiscal Year: 2003
    ..Project I examines the control of matrix metalloproteinases, enzymes essential for mediating the invasive establishment of ectopic I examines the control of matrix ..
  66. Endocrine Status of MG Stroma Alters Breast CA Invasion
    Pepper Schedin; Fiscal Year: 2004
    ..parturition or weaning-induced mammary gland involution, mammary stroma is degraded and stroma levels of matrix metalloproteinases (MMP) and pro-inflammatory mediators are elevated...
  67. MAST CELL MATRIX METALLOPROTEINASES IN LUNG INJURY
    Kenneth Fang; Fiscal Year: 2000
    ..The preliminary data demonstrate that dog mastocytoma cells secrete and activate their own matrix metalloproteinases (MMPs), supporting the hypothesis that mast cells participate in the regulation of extracellular matrix ..
  68. Glycosaminoglycans For IC Pathophysiology and Prognosis
    Vinata Lokeshwar; Fiscal Year: 2005
    ..IC urothelial cultures secrete higher levels of matrix metalloproteinases (MMPs)-2 and -9, when compared with normal urothelial cells, suggesting an association between MMPs and ..
  69. Transcriptional Regulation of Matrix Metalloproteinase-3 (MMP-3)
    RUTH BORGHAEI; Fiscal Year: 2007
    ..IL-1 contributes to loss of attachment and alveolar bone destruction by increasing expression of matrix metalloproteinases. MMP-3 has broad substrate specificity and can activate other pro-MMP...
  70. MECHANISMS OF FETAL MEMBRANE RUPTURE
    Jerome F Strauss; Fiscal Year: 2010
    ..Studies conducted during the current period of support revealed that polymorphisms in genes encoding matrix metalloproteinases (MMPs) contribute to risk of unscheduled membrane rupture...
  71. Matrix Metalloproteinases and PPAR Gamma in Sarcoidosis
    Daniel Culver; Fiscal Year: 2009
    ..b>Matrix metalloproteinases (MMPs) are attractive candidate mediators of disease progression in sarcoidosis, since they are capable ..
  72. Domoic Acid and Neonatal Microglia Activation
    Alejandro Mayer; Fiscal Year: 2004
    ..marine toxin domoic acid activates neonatal brain microglia and causes subsequent release of neurotoxic matrix metalloproteinases and cytokines"...
  73. Pathogenesis of Borrelia burgdorferi induced arthritis
    Linden Hu; Fiscal Year: 2006
    ..b>Matrix metalloproteinases (MMPs) are host enzymes that are capable of digesting multiple components of human cartilage...
  74. Understanding the Role of MMPs in Basement Membrane Breaching In vivo
    LAURA CATHERINE KELLEY; Fiscal Year: 2012
    ..b>Matrix metalloproteinases are overexpressed in cells responsible for tissue remodeling, wound healing, and cancer and are ..
  75. Prevention of Type 1 Diabetes with MMP Inhibitors
    David Bleich; Fiscal Year: 2003
    ..Recently, much attention has been focused on the regulation of matrix metalloproteinases (MMPs) in diseases ranging from metastatic breast cancer to rheumatoid arthritis because these key ..