protein tyrosine phosphatase

Summary

Summary: An enzyme group that specifically dephosphorylates phosphotyrosyl residues in selected proteins. Together with PROTEIN-TYROSINE KINASE, it regulates tyrosine phosphorylation and dephosphorylation in cellular signal transduction and may play a role in cell growth control and carcinogenesis. EC 3.1.3.48.

Top Publications

  1. ncbi Protein tyrosine phosphatase alpha (PTP alpha) knockout mice show deficits in Morris water maze learning, decreased locomotor activity, and decreases in anxiety
    Matthew R Skelton
    Division of Developmental Biology, Cincinnati Children s Hospital Research Foundation, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Brain Res 984:1-10. 2003
  2. ncbi The 'Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling
    Benjamin G Neel
    Cancer Biology Program Division of Hematology Oncology Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
    Trends Biochem Sci 28:284-93. 2003
  3. pmc Blocking of interferon-induced Jak-Stat signaling by Japanese encephalitis virus NS5 through a protein tyrosine phosphatase-mediated mechanism
    Ren Jye Lin
    Institute of Biomedical Sciences, Academia Sinica, Nankang, Taipei 11529, Taiwan, Republic of China
    J Virol 80:5908-18. 2006
  4. ncbi Attenuation of leptin action and regulation of obesity by protein tyrosine phosphatase 1B
    Alan Cheng
    McGill Cancer Center, McGill University, H3G 1Y6, Montreal, Quebec, Canada
    Dev Cell 2:497-503. 2002
  5. ncbi The protein tyrosine phosphatase, Shp2, is required for the complete activation of the RAS/MAPK pathway by brain-derived neurotrophic factor
    John B Easton
    Department of Molecular Pharmacology, St Jude Children s Research Hospital, North Lauderdale, Memphis, Tennessee, USA
    J Neurochem 97:834-45. 2006
  6. ncbi PEST domain-enriched tyrosine phosphatase (PEP) regulation of effector/memory T cells
    Kiminori Hasegawa
    Department of Immunology, Genentech, Inc, One DNA Way, South San Francisco, CA 94080, USA
    Science 303:685-9. 2004
  7. ncbi Oxidation state of the active-site cysteine in protein tyrosine phosphatase 1B
    Rob L M Van Montfort
    Astex Technology Ltd, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, UK
    Nature 423:773-7. 2003
  8. ncbi Redox regulation of protein tyrosine phosphatase 1B involves a sulphenyl-amide intermediate
    Annette Salmeen
    Section of Structural Biology, Institute of Cancer Research, Chester Beatty Laboratories, 237 Fulham Road, London SW3 6JB, UK
    Nature 423:769-73. 2003
  9. ncbi Shp2 regulates SRC family kinase activity and Ras/Erk activation by controlling Csk recruitment
    Si Qing Zhang
    Cancer Biology Program, Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115 USA
    Mol Cell 13:341-55. 2004
  10. ncbi The function of the protein tyrosine phosphatase SHP-1 in cancer
    Chengyu Wu
    Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worchester, MA 01605, USA
    Gene 306:1-12. 2003

Detail Information

Publications353 found, 100 shown here

  1. ncbi Protein tyrosine phosphatase alpha (PTP alpha) knockout mice show deficits in Morris water maze learning, decreased locomotor activity, and decreases in anxiety
    Matthew R Skelton
    Division of Developmental Biology, Cincinnati Children s Hospital Research Foundation, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Brain Res 984:1-10. 2003
    ..The data suggest that PTPalpha serves a regulatory function in learning and other forms of neuroplasticity...
  2. ncbi The 'Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling
    Benjamin G Neel
    Cancer Biology Program Division of Hematology Oncology Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
    Trends Biochem Sci 28:284-93. 2003
    ..Despite these efforts, however, the key targets of each Shp have remained elusive. Identifying these substrates remains a major challenge for future research...
  3. pmc Blocking of interferon-induced Jak-Stat signaling by Japanese encephalitis virus NS5 through a protein tyrosine phosphatase-mediated mechanism
    Ren Jye Lin
    Institute of Biomedical Sciences, Academia Sinica, Nankang, Taipei 11529, Taiwan, Republic of China
    J Virol 80:5908-18. 2006
    ..We suggest that JEV NS5 is an IFN antagonist and that it may play a role in blocking IFN-stimulated Jak-Stat signaling via activation of PTPs during JEV infection...
  4. ncbi Attenuation of leptin action and regulation of obesity by protein tyrosine phosphatase 1B
    Alan Cheng
    McGill Cancer Center, McGill University, H3G 1Y6, Montreal, Quebec, Canada
    Dev Cell 2:497-503. 2002
    ..Mice deficient in protein tyrosine phosphatase 1B (PTP1B) are resistant to diabetes and diet-induced obesity, prompting us to further define the ..
  5. ncbi The protein tyrosine phosphatase, Shp2, is required for the complete activation of the RAS/MAPK pathway by brain-derived neurotrophic factor
    John B Easton
    Department of Molecular Pharmacology, St Jude Children s Research Hospital, North Lauderdale, Memphis, Tennessee, USA
    J Neurochem 97:834-45. 2006
    ..Now, we have intriguing data that indicates BDNF induces association of the SH2 domain containing protein tyrosine phosphatase, Shp2, with FRS2...
  6. ncbi PEST domain-enriched tyrosine phosphatase (PEP) regulation of effector/memory T cells
    Kiminori Hasegawa
    Department of Immunology, Genentech, Inc, One DNA Way, South San Francisco, CA 94080, USA
    Science 303:685-9. 2004
    ..These results revealed a central role for PEP in negatively regulating specific aspects of T cell development and function...
  7. ncbi Oxidation state of the active-site cysteine in protein tyrosine phosphatase 1B
    Rob L M Van Montfort
    Astex Technology Ltd, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, UK
    Nature 423:773-7. 2003
    ..the crystal structures of the regulatory sulphenic and irreversible sulphinic and sulphonic acids of protein tyrosine phosphatase 1B (PTP1B), an important enzyme in the negative regulation of the insulin receptor and a therapeutic ..
  8. ncbi Redox regulation of protein tyrosine phosphatase 1B involves a sulphenyl-amide intermediate
    Annette Salmeen
    Section of Structural Biology, Institute of Cancer Research, Chester Beatty Laboratories, 237 Fulham Road, London SW3 6JB, UK
    Nature 423:769-73. 2003
    ..Here we describe a structural analysis of the redox-dependent regulation of protein tyrosine phosphatase 1B (PTP1B), which is reversibly inhibited by oxidation after cells are stimulated with insulin and ..
  9. ncbi Shp2 regulates SRC family kinase activity and Ras/Erk activation by controlling Csk recruitment
    Si Qing Zhang
    Cancer Biology Program, Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115 USA
    Mol Cell 13:341-55. 2004
    ..Decreased phosphorylation/activation of other SFK substrates may explain additional consequences of Shp2 deficiency, including altered cell spreading, stress fibers, focal adhesions, and motility...
  10. ncbi The function of the protein tyrosine phosphatase SHP-1 in cancer
    Chengyu Wu
    Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worchester, MA 01605, USA
    Gene 306:1-12. 2003
    SHP-1, an SH2 domain-containing protein tyrosine phosphatase, is primarily expressed in hematopoietic cells and behaves as a key regulator controlling intracellular phosphotyrosine levels in lymphocytes...
  11. ncbi A critical role for the protein tyrosine phosphatase receptor type Z in functional recovery from demyelinating lesions
    Sheila Harroch
    Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Nat Genet 32:411-4. 2002
    ..Ptprz encodes protein tyrosine phosphatase receptor type Z (Ptpz, also designated Rptpbeta), which is expressed primarily in the nervous system ..
  12. ncbi Cellular prostatic acid phosphatase: a protein tyrosine phosphatase involved in androgen-independent proliferation of prostate cancer
    Suresh Veeramani
    Department of Biochemistry and Molecular Biology, College of Medicine, University of Nebraska Medical Center, Omaha, 68198, USA
    Endocr Relat Cancer 12:805-22. 2005
    ..It is now evident that cPAcP functions as a neutral protein tyrosine phosphatase (PTP) in prostate cancer cells and dephosphorylates HER-2/ErbB-2/Neu (HER-2: human epidermal growth ..
  13. ncbi Negative feedback regulation of FGF signaling levels by Pyst1/MKP3 in chick embryos
    Maxwell C Eblaghie
    Division of Cell and Developmental Biology, School of Life Sciences, University of Dundee, Dow Street, United Kingdom
    Curr Biol 13:1009-18. 2003
    ..High-level Pyst1/Mkp3 expression has recently been found at many sites of known FGF signaling in mouse embryos, but the significance of this association and its function are not known...
  14. ncbi Protein tyrosine phosphatase: enzymatic assays
    Jacqueline Montalibet
    Department of Biochemistry and Molecular Biology, Merck Frosst Center for Therapeutic Research, P O Box 1005, Pointe Claire, Que, Canada H9R 4P8
    Methods 35:2-8. 2005
    ..These assays are useful to identify and characterize tyrosine phosphatases and are commonly used to evaluate the efficiency of inhibitors...
  15. ncbi An adenovirus carrying the rat protein tyrosine phosphatase eta suppresses the growth of human thyroid carcinoma cell lines in vitro and in vivo
    Rodolfo Iuliano
    Dipartimento di Medicina Sperimentale e Clinica, Facolta di Medicina e Chirurgia di Catanzaro, Università degli Studi di Catanzaro Magna Graecia, 88100 Catanzaro, Italy
    Cancer Res 63:882-6. 2003
    ..These data suggest that gene therapy based on restoration of PTPeta function has potential in the treatment of human thyroid malignant neoplasias...
  16. ncbi Restraint of proinflammatory cytokine biosynthesis by mitogen-activated protein kinase phosphatase-1 in lipopolysaccharide-stimulated macrophages
    Peili Chen
    Stress Signaling Unit, Laboratory of Cellular and Molecular Biology, National Institute on Aging, Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA
    J Immunol 169:6408-16. 2002
    ..These findings highlight MKP-1 as a critical negative regulator of the macrophage inflammatory response, underscoring its premise as a potential target for developing novel anti-inflammatory drugs...
  17. ncbi Disruption of mptpB impairs the ability of Mycobacterium tuberculosis to survive in guinea pigs
    Ramandeep Singh
    Department of Biochemistry, University of Delhi South Campus, Benito Juarez Road, New Delhi 110021, India
    Mol Microbiol 50:751-62. 2003
    ..These observations demonstrate a role of MptpB in the pathogenesis of M. tuberculosis...
  18. ncbi High expression of PRL-3 promotes cancer cell motility and liver metastasis in human colorectal cancer: a predictive molecular marker of metachronous liver and lung metastases
    Hirotaka Kato
    Division of Surgical Pathology, Department of Biomedical Informatics, Kobe University Graduate School of Medicine, Kobe, Japan
    Clin Cancer Res 10:7318-28. 2004
    ..Overexpression of PRL-3 has been implicated in colorectal cancer metastases. We investigated the significance of PRL-3 expression in the progression and development of colorectal cancer...
  19. ncbi PTPN22 C1858T polymorphism in Colombian patients with autoimmune diseases
    L M Gomez
    Cellular Biology and Immunogenetics Unit CBIU, Corporación para Investigaciones Biológicas CIB and Universidad de Antioquia, Medellin, Colombia, CSIC, Granada, Spain
    Genes Immun 6:628-31. 2005
    A functional single nucleotide polymorphism (SNP) C1858T in the protein tyrosine phosphatase nonreceptor 22 (PTPN22) gene encoding an intracellular phosphatase with negative regulatory effects on T-cell activation is associated with some ..
  20. pmc PTP alpha regulates integrin-stimulated FAK autophosphorylation and cytoskeletal rearrangement in cell spreading and migration
    Li Zeng
    Cell Regulation Laboratory, Institute of Molecular and Cell Biology, Singapore 117609, Singapore
    J Cell Biol 160:137-46. 2003
    We investigated the molecular and cellular actions of receptor protein tyrosine phosphatase (PTP) alpha in integrin signaling using immortalized fibroblasts derived from wild-type and PTP alpha-deficient mouse embryos...
  21. ncbi PTP-PEST controls motility through regulation of Rac1
    Sarita K Sastry
    Department of Cell and Developmental Biology and Lineberger Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA
    J Cell Sci 115:4305-16. 2002
    The cytoplasmic protein tyrosine phosphatase, PTP-PEST, associates with the focal adhesion proteins p130cas and paxillin and has recently been implicated in cell migration...
  22. ncbi Microarray analysis reveals glucocorticoid-regulated survival genes that are associated with inhibition of apoptosis in breast epithelial cells
    Wei Wu
    Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    Cancer Res 64:1757-64. 2004
    ..Given the widespread clinical administration of dexamethasone before chemotherapy, understanding GR-induced survival mechanisms is essential for achieving optimal therapeutic responses...
  23. ncbi Protein phosphorylation on tyrosine in bacteria
    Alain J Cozzone
    Institut de Biologie et Chimie des Proteines, 7 passage du Vercors, 69007 Lyon, France
    Arch Microbiol 181:171-81. 2004
    ..Therefore, a new concept has emerged suggesting the existence of a biological link between protein-tyrosine phosphorylation and bacterial pathogenicity...
  24. ncbi Monitoring the activation state of the insulin-like growth factor-1 receptor and its interaction with protein tyrosine phosphatase 1B using bioluminescence resonance energy transfer
    Christophe Blanquart
    Department of Cell Biology, Institut Cochin, 22 rue Mechain, 75014 Paris, France
    Mol Pharmacol 68:885-94. 2005
    ..growth factor-1 (IGF-1) receptors (IGF1R) and 2) IGF1R interaction with a substrate-trapping mutant of protein tyrosine phosphatase 1B (PTP1B-D181A) in living cells...
  25. ncbi Drosophila liprin-alpha and the receptor phosphatase Dlar control synapse morphogenesis
    Nancy Kaufmann
    Department of Cell Biology, Program in Neuroscience and DFCI Harvard Cancer Center, Harvard Medical School, Boston, MA 02115, USA
    Neuron 34:27-38. 2002
    Here, we examine the synaptic function of the receptor protein tyrosine phosphatase (RPTP), Dlar, and an associated intracellular protein, Dliprin-alpha, at the Drosophila larval neuromuscular junction...
  26. pmc Suppression of the protein tyrosine phosphatase receptor type O gene (PTPRO) by methylation in hepatocellular carcinomas
    Tasneem Motiwala
    Department of Molecular and Cellular Biochemistry, The Ohio State University, Columbus, OH 43210, USA
    Oncogene 22:6319-31. 2003
    ..Here, we describe identification of one methylated and downregulated gene as the rat protein tyrosine phosphatase receptor type O (PTPRO) and one amplified gene as rat C-MYC...
  27. ncbi The tyrosine phosphatase PRL-1 localizes to the endoplasmic reticulum and the mitotic spindle and is required for normal mitosis
    Jing Wang
    DNAX Research Institute, Palo Alto, California 94304, USA
    J Biol Chem 277:46659-68. 2002
    ..Together, these results suggest that PRL-1 function is regulated in a cell cycle-dependent manner and implicate PRL-1 in regulating progression through mitosis, possibly by modulating spindle dynamics...
  28. ncbi Protein tyrosine phosphatase inhibition reduces degeneration of dopaminergic substantia nigra neurons and projections in 6-OHDA treated adult rats
    Peng Yang
    Kentucky Spinal Cord Injury Research Center and Department of Neurological Surgery, University of Louisville, Louisville, KY 40292, USA
    Eur J Neurosci 25:1332-40. 2007
    ..The neuroprotective effects of this small molecule protein tyrosine phosphatase inhibitor represent a proof-of-principle for a novel treatment strategy in a model for Parkinson's ..
  29. ncbi A single-nucleotide polymorphism in the gene encoding lymphoid protein tyrosine phosphatase (PTPN22) confers susceptibility to generalised vitiligo
    I Canton
    Division of Clinical Sciences North, University of Sheffield, Sheffield, UK
    Genes Immun 6:584-7. 2005
    ..Recently, the missense R620W polymorphism in the PTPN22 gene, which encodes lymphoid protein tyrosine phosphatase (LYP), has been associated with susceptibility to autoimmune disorders...
  30. ncbi Turn-off, drop-out: functional state switching of cadherins
    Jack Lilien
    Department of Biological Sciences, The University of Iowa, Iowa City, IA 52242, USA
    Dev Dyn 224:18-29. 2002
    ..Extracellular cues that bias this critical regulatory interaction toward increased phosphorylation of beta-catenin may be a critical component of many developmental events...
  31. ncbi Association of the single nucleotide polymorphism C1858T of the PTPN22 gene with type 1 diabetes
    Martha B Ladner
    Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
    Hum Immunol 66:60-4. 2005
    The PTPN22 (protein tyrosine phosphatase N22) gene encodes the protein tyrosine phosphatase Lyp...
  32. ncbi Functional significance of the LAR receptor protein tyrosine phosphatase family in development and diseases
    Melanie J Chagnon
    McGill Cancer Centre and Department of Biochemistry, McGill University, McIntyre Medical Sciences Building, 3655 Promenade Sir William Osler, Room 701, Montreal, QC H3G 1Y6, Canada
    Biochem Cell Biol 82:664-75. 2004
    ..This RPTP subfamily is likely to become important as drug targets in these various human pathologies, but further understanding of their complex signal transduction cascades will be required...
  33. ncbi Regulation of receptor tyrosine kinase signaling by protein tyrosine phosphatase-1B
    Fawaz G Haj
    Cancer Biology Program, Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 278:739-44. 2003
    ..Based on in vitro and ex vivo studies, protein tyrosine phosphatase-1B (PTP1B) was implicated in the regulation of several RTKs, yet mice lacking PTP1B show defects mainly ..
  34. pmc Using Drosophila to decipher how mutations associated with human branchio-oto-renal syndrome and optical defects compromise the protein tyrosine phosphatase and transcriptional functions of eyes absent
    Mousumi Mutsuddi
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
    Genetics 170:687-95. 2005
    ..as a transcriptional coactivator by mediating protein-protein interactions and possesses intrinsic protein tyrosine phosphatase activity...
  35. ncbi Levels of protein tyrosine phosphatase 1B determine susceptibility to apoptosis in serum-deprived hepatocytes
    Agueda Gonzalez-Rodriguez
    Instituto de Investigaciones Biomédicas Alberto Sols Centro Mixto CSIC UAM, C Arturo Pérez Duperier 4, Madrid, Spain
    J Cell Physiol 212:76-88. 2007
    b>Protein tyrosine phosphatase 1B (PTP1B) is a negative regulator of tyrosine kinase growth factor signaling...
  36. pmc Reactive oxygen species as essential mediators of cell adhesion: the oxidative inhibition of a FAK tyrosine phosphatase is required for cell adhesion
    Paola Chiarugi
    Department of Biochemical Sciences, University of Florence, Italy
    J Cell Biol 161:933-44. 2003
    ..Hence, we have outlined a redox circuitry whereby, upon cell adhesion, oxidative inhibition of a protein tyrosine phosphatase promotes the phosphorylation/activation and the downstream signaling of FAK and, as a final event, cell ..
  37. ncbi PTP1B regulates leptin signal transduction in vivo
    Janice M Zabolotny
    Division of Endocrinology and Metabolism, Division of Hematology and Oncology, Department of Medicine, Boston, MA, USA
    Dev Cell 2:489-95. 2002
    ..Our data indicate that PTP1B regulates leptin signaling in vivo, likely by targeting Jak2. PTP1B may be a novel target to treat leptin resistance in obesity...
  38. ncbi Division of the nucleolus and its release of CDC14 during anaphase of meiosis I depends on separase, SPO12, and SLK19
    Sara B C Buonomo
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030, Vienna, Austria
    Dev Cell 4:727-39. 2003
    ..It has two mechanistically different roles during meiosis I. Loss of the protease-independent function alone results in a second meiotic division occurring on anaphase I spindles in spo12delta and slk19delta mutants...
  39. pmc The protein tyrosine phosphatase Pez is a major phosphatase of adherens junctions and dephosphorylates beta-catenin
    Carol Wadham
    Hanson Centre for Cancer Research, Institute of Medical and Veterinary Science, Adelaide, SA 5000, Australia
    Mol Biol Cell 14:2520-9. 2003
    ..We have previously shown that the protein tyrosine phosphatase Pez is concentrated at intercellular junctions in confluent, quiescent monolayers but is nuclear in ..
  40. pmc The role of protein tyrosine phosphatase 1B in Ras signaling
    Nadia Dubé
    McGill Cancer Centre and Department of Biochemistry, McGill University, 3655 Promenade Sir William Osler, Room 715, Montreal, QC, Canada H3G 1Y6
    Proc Natl Acad Sci U S A 101:1834-9. 2004
    b>Protein tyrosine phosphatase (PTP) 1B has been implicated as a negative regulator of multiple signaling pathways downstream of receptor tyrosine kinases...
  41. ncbi Ursolic acid and its derivative inhibit protein tyrosine phosphatase 1B, enhancing insulin receptor phosphorylation and stimulating glucose uptake
    Wei Zhang
    National Center for Drug Screening, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, PR China
    Biochim Biophys Acta 1760:1505-12. 2006
    b>Protein tyrosine phosphatase 1B (PTP1B) is a key element in the negative regulation of the insulin signaling pathway and may play an important role in diabetes and obesity...
  42. ncbi Catalytic domain of PRL-3 plays an essential role in tumor metastasis: formation of PRL-3 tumors inside the blood vessels
    Ke Guo
    Institute of Molecular and Cell Biology, Singapore
    Cancer Biol Ther 3:945-51. 2004
    PRL-3, a protein tyrosine phosphatase, has attracted much attention as its transcript is consistently upregulated in the process of colorectal cancer metastases to secondary organs...
  43. ncbi Replication of an association between the lymphoid tyrosine phosphatase locus (LYP/PTPN22) with type 1 diabetes, and evidence for its role as a general autoimmunity locus
    Deborah Smyth
    Juvenile Diabetes Research Foundation JDRF Wellcome Trust WT Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research CIMR, University of Cambridge, Cambridge, UK
    Diabetes 53:3020-3. 2004
    ..nucleotide polymorphism (SNP), 1858C>T, in the gene PTPN22, encoding Arg620Trp in the lymphoid protein tyrosine phosphatase (LYP), which has been shown to be a negative regulator of T-cell activation, is associated with an ..
  44. pmc Analysis of families in the multiple autoimmune disease genetics consortium (MADGC) collection: the PTPN22 620W allele associates with multiple autoimmune phenotypes
    Lindsey A Criswell
    Rosalind Russell Medical Research Center for Arthritis, Department of Medicine, University of California San Francisco, San Francisco, CA, USA
    Am J Hum Genet 76:561-71. 2005
    ..DNA and clinical data for the MADGC families are available to the scientific community; these data will provide a valuable resource for the dissection of the complex genetic factors that underlie the various autoimmune phenotypes...
  45. ncbi Liver X receptor agonists ameliorate TNFalpha-induced insulin resistance in murine brown adipocytes by downregulating protein tyrosine phosphatase-1B gene expression
    S Fernandez-Veledo
    Department of Biochemistry and Molecular Biology II, Faculty of Pharmacy, Complutense University, Madrid, Spain
    Diabetologia 49:3038-48. 2006
    ..Therefore, we decided to investigate the ability of NR1HR agonists to ameliorate TNFalpha-induced insulin resistance in brown adipocytes...
  46. pmc Site-selective regulation of platelet-derived growth factor beta receptor tyrosine phosphorylation by T-cell protein tyrosine phosphatase
    Camilla Persson
    Ludwig Institute for Cancer Research, Uppsala Branch, Biomedical Center, S 751 24 Uppsala, Sweden
    Mol Cell Biol 24:2190-201. 2004
    ..In summary, our findings identify TC-PTP as a previously unrecognized negative regulator of PDGF beta receptor signaling and support the general notion that PTPs display site selectivity in their action on tyrosine kinase receptors...
  47. ncbi Improvement of peripheral endothelial dysfunction by protein tyrosine phosphatase inhibitors in heart failure
    Magali Vercauteren
    INSERM U644, Federate Institute for Multidisciplinary Research on Peptides, Rouen University Medical School, Rouen, France
    Circulation 114:2498-507. 2006
    ..eNOS) by flow requires tyrosine phosphorylation, we tested whether endothelial dysfunction could be corrected by increasing phosphotyrosine levels using protein tyrosine phosphatase (PTP) inhibitors and especially inhibitors of PTP1B.
  48. ncbi Intracellular zinc fluctuations modulate protein tyrosine phosphatase activity in insulin/insulin-like growth factor-1 signaling
    Hajo Haase
    Center for Biochemical and Biophysical Sciences and Medicine, Harvard Medical School, One Kendall Square, Bldg 600, 3rd Floor, Cambridge, MA 02139, USA
    Exp Cell Res 291:289-98. 2003
    ..In the context of the emerging concept that intracellular zinc is tightly regulated and fluctuates dynamically, these results suggest that a pool of cellular zinc modulates phosphorylation signaling...
  49. ncbi Insulin signaling pathways in time and space
    Alan R Saltiel
    Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109 0650, USA
    Trends Cell Biol 12:65-71. 2002
    ..Also, the rapid termination of tyrosine or lipid phosphorylation by phosphatases or serine kinases might tightly control the strength of a signaling pathway, thus determining its effect on growth, differentiation and metabolism...
  50. ncbi Mitotic activation of protein-tyrosine phosphatase alpha and regulation of its Src-mediated transforming activity by its sites of protein kinase C phosphorylation
    Xin Min Zheng
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA
    J Biol Chem 277:21922-9. 2002
    ....
  51. ncbi Role of the SHP-2 tyrosine phosphatase in cytokine-induced signaling and cellular response
    Cheng Kui Qu
    Department of Hematopoiesis, Jerome H Holland Laboratory, American Red Cross, Rockville, MD 20855, USA
    Biochim Biophys Acta 1592:297-301. 2002
    ..SHP-2, a Src homology (SH) 2 domain-containing protein tyrosine phosphatase (PTP), is widely involved in a variety of signaling pathways triggered by cytokines and growth factors, ..
  52. ncbi A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes
    Nunzio Bottini
    Program of Signal Transduction, Cancer Research Center, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Genet 36:337-8. 2004
    We report that a single-nucleotide polymorphism (SNP) in the gene (PTPN22) encoding the lymphoid protein tyrosine phosphatase (LYP), a suppressor of T-cell activation, is associated with type 1 diabetes mellitus (T1D)...
  53. ncbi Regulation of innate and adaptive immune responses by MAP kinase phosphatase 5
    Yongliang Zhang
    Department of Immunology, University of Washington, Seattle, Washington 98195 7650, USA
    Nature 430:793-7. 2004
    ..Therefore, MKP5 has a principal function in both innate and adaptive immune responses, and represents a novel target for therapeutic intervention of immune diseases...
  54. ncbi Tick vitellin is dephosphorylated by a protein tyrosine phosphatase during egg development: effect of dephosphorylation on VT proteolysis
    Alan B Silveira
    Instituto de Bioquimica Medica, Programa de Biotecnologia e Biologia Molecular, CCS, Universidade Federal do Rio de Janeiro, UFRJ, P O Box 68041, Cidade Universitaria, Ilha do Fundao, Rio de Janeiro RJ 21941 590, Brazil
    Insect Biochem Mol Biol 36:200-9. 2006
    ..Altogether, these data are the first to show that phosphotyrosine residues are present in a yolk protein, and that such residues might be involved in the regulation of VT breakdown during egg development...
  55. ncbi Regulation of Lck and Fyn tyrosine kinase activities by transmembrane protein tyrosine phosphatase leukocyte common antigen-related molecule
    Kazutake Tsujikawa
    Department of Immunology, Graduate School of Pharmaceutical Sciences, Osaka University, Yamadaoka, Suita, Osaka, Japan
    Mol Cancer Res 1:155-63. 2002
    Leukocyte common antigen-related molecule (LAR) is a receptor-like protein tyrosine phosphatase (PTPase) with two PTPase domains...
  56. ncbi The two isoforms of the Caenorhabditis elegans leukocyte-common antigen related receptor tyrosine phosphatase PTP-3 function independently in axon guidance and synapse formation
    Brian D Ackley
    Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Cruz, California 95064, USA
    J Neurosci 25:7517-28. 2005
    ..Overexpression of PTP-3A is able to bypass the requirement for nid-1 for the localization of SYD-2 and RIM. We propose that PTP-3A acts as a molecular link between the extracellular matrix and alpha-liprin during synaptogenesis...
  57. ncbi Intramolecular dynamics of low molecular weight protein tyrosine phosphatase in monomer-dimer equilibrium studied by NMR: a model for changes in dynamics upon target binding
    Tomas Akerud
    Department of Biophysical Chemistry, Lund University, Box 124, SE 221 00 Lund, Sweden
    J Mol Biol 322:137-52. 2002
    Low molecular weight protein tyrosine phosphatase (LMW-PTP) dimerizes in the phosphate-bound state in solution with a dissociation constant of K(d)=1.5(+/-0.1)mM and an off-rate on the order of 10(4)s(-1)...
  58. ncbi The differentiation of skeletal muscle cells involves a protein-tyrosine phosphatase-alpha-mediated C-Src signaling pathway
    Huogen Lu
    Department of Medicine, Mount Sinai Hospital and The University Health Network and the Banting and Best Diabetes Center, University of Toronto, Toronto, Ontario M5G 1X5, Canada
    J Biol Chem 277:46687-95. 2002
    ..Together, these data indicate that PTPalpha is involved in the regulation of L6 myoblast growth and skeletal muscle cell differentiation via an Src-mediated signaling pathway...
  59. ncbi Protein tyrosine phosphatase 1B negatively regulates leptin signaling in a hypothalamic cell line
    Wiweka Kaszubska
    Metabolic Disease Research, Global Pharmaceutical Products Division, Department 47R, Bldg AP10, 100 Abbott Park Road, Abott Park, IL 60064 6099, USA
    Mol Cell Endocrinol 195:109-18. 2002
    b>Protein tyrosine phosphatase 1B (PTP1B) has recently been implicated in the regulation of body weight. A surprising phenotype of PTP1B-deficient mice is their resistance to diet-induced obesity...
  60. pmc Protein tyrosine phosphatase kappa and SHP-1 are involved in the regulation of cell-cell contacts at adherens junctions in the exocrine pancreas
    J Schnekenburger
    Department of Medicine B, Westfalische Wilhelms Universitat Munster, Germany
    Gut 54:1445-55. 2005
    ..We have previously shown that cell contacts between pancreatic acinar cells dissociate early in pancreatitis and that this is a prerequisite for the development of pancreatic oedema. Here we studied the underlying mechanism...
  61. pmc Stimulation of the alveolar macrophage respiratory burst by ADP causes selective glutathionylation of protein tyrosine phosphatase 1B
    Alessandra Rinna
    School of Natural Sciences, University of California Merced, P O Box 2039, Merced, CA 95344, USA
    Free Radic Biol Med 41:86-91. 2006
    ....
  62. ncbi The transcription factor Eyes absent is a protein tyrosine phosphatase
    Tina L Tootle
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
    Nature 426:299-302. 2003
    ..of the haloacid dehalogenase (HAD) superfamily, and propose a function for it as a non-thiol-based protein tyrosine phosphatase. Experiments performed in cultured Drosophila cells and in vitro indicate that Eyes absent has ..
  63. pmc Protein tyrosine phosphatase receptor-type O (PTPRO) exhibits characteristics of a candidate tumor suppressor in human lung cancer
    Tasneem Motiwala
    Department of Molecular and Cellular Biochemistry, College of Medicine, Ohio State University, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 101:13844-9. 2004
    Previous study in our laboratory demonstrated suppression of the gene for protein tyrosine phosphatase receptor-type O (PTPRO) in primary and established rat hepatomas...
  64. ncbi An overview of the protein tyrosine phosphatase superfamily
    Wei Qing Wang
    Department of Molecular Pharmacology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Curr Top Med Chem 3:739-48. 2003
    The human genome encodes approximately 100 phosphatases that belong to the protein tyrosine phosphatase (PTP) superfamily, whose substrates range from proteins to phosphoinositides and mRNAs...
  65. ncbi Hepatic PTP-1B expression regulates the assembly and secretion of apolipoprotein B-containing lipoproteins: evidence from protein tyrosine phosphatase-1B overexpression, knockout, and RNAi studies
    Wei Qiu
    Department of Laboratory Medicine and Pathobiology, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    Diabetes 53:3057-66. 2004
    b>Protein tyrosine phosphatase-1B (PTP-1B) plays an important role in regulation of insulin signal transduction, and modulation of PTP-1B expression seems to have a profound effect on insulin sensitivity and diet-induced weight gain...
  66. ncbi Association of protein tyrosine phosphatase-N1 polymorphisms with coronary calcified plaque in the Diabetes Heart Study
    Kathryn P Burdon
    Department of Biochemistry, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Diabetes 55:651-8. 2006
    ..The PTPN1 gene encodes protein tyrosine phosphatase-1B, which is ubiquitously expressed and plays a role in the regulation of several signaling pathways...
  67. ncbi Association testing of the protein tyrosine phosphatase 1B gene (PTPN1) with type 2 diabetes in 7,883 people
    Jose C Florez
    Department of Endocrinology, University Hospital MAS, Lund University, Malmo, Sweden
    Diabetes 54:1884-91. 2005
    b>Protein tyrosine phosphatase (PTP)-1B, encoded by the PTPN1 gene, inactivates the insulin signal transduction cascade by dephosphorylating phosphotyrosine residues in insulin signaling molecules...
  68. ncbi Receptor protein tyrosine phosphatase sigma inhibits axon regrowth in the adult injured CNS
    Przemyslaw S Sapieha
    Department of Pathology and Cell Biology, Universite de Montreal, 2900, Boulevard Edouard Montpetit, Pavillon Principal, Room N 535, Montreal, Quebec, Canada H3T 1J4
    Mol Cell Neurosci 28:625-35. 2005
    Recently, receptor protein tyrosine phosphatase-sigma (RPTPsigma) has been shown to inhibit axon regeneration in injured peripheral nerves...
  69. pmc RPTP-alpha acts as a transducer of mechanical force on alphav/beta3-integrin-cytoskeleton linkages
    Gotz von Wichert
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    J Cell Biol 161:143-53. 2003
    ....
  70. pmc The cell-specific phenotype of the polymorphic vacA midregion is independent of the appearance of the cell surface receptor protein tyrosine phosphatase beta
    David A G Skibinski
    IRIS, Chiron Srl, Via Fiorentina 1, 53100 Siena, Italy
    Infect Immun 74:49-55. 2006
    ..of HL-60 cells has been previously associated with the appearance of the cell surface receptor protein tyrosine phosphatase beta (RPTPbeta)...
  71. ncbi Role of the Grb2-associated binder 1/SHP-2 interaction in cell growth and transformation
    Marina Holgado-Madruga
    Department of Microbiology and Immunology, The Kimmel Cancer Institute, Thomas Jefferson University, 233 South 10th Street, 1002 BLSB, Philadelphia, PA 19107, USA
    Cancer Res 64:2007-15. 2004
    ..On the basis of its role in growth and transformation, the Gab1/SHP-2 interaction may become an attractive target for the pharmacologic intervention of malignant cell growth...
  72. ncbi Low molecular weight protein tyrosine phosphatase and caveolin-1: interaction and isoenzyme-dependent regulation
    Anna Caselli
    Department of Biochemical Sciences and Center for Research, Transfer, High Education DENOTHE, University of Florence, Florence, Italy
    Biochemistry 46:6383-92. 2007
    ..The caveolin scaffolding domain is directly involved in the observed phenomena...
  73. pmc Status epilepticus-induced somatostatinergic hilar interneuron degeneration is regulated by striatal enriched protein tyrosine phosphatase
    Yun Sik Choi
    Department of Neuroscience, Ohio State University, Columbus, Ohio 43210, USA
    J Neurosci 27:2999-3009. 2007
    ..Here, we report that high levels of the striatal-enriched protein tyrosine phosphatase (STEP), a key regulator of ERK/MAPK signaling, are found in vulnerable somatostatin-immunoreactive ..
  74. ncbi Natural compounds as a source of protein tyrosine phosphatase inhibitors: application to the rational design of small-molecule derivatives
    Carmen V Ferreira
    Laboratory of Cell Signaling, Departamento de Bioquimica, Instituto de Biologia, Universidade Estadual de Campinas UNICAMP, CP 6109, CEP 13083 970, Campinas, Sao Paulo, Brazil
    Biochimie 88:1859-73. 2006
    ..Together, all these factors will lead to new avenues to treat clinical disease based on PTP inhibition...
  75. ncbi DSD-1-Proteoglycan/Phosphacan and receptor protein tyrosine phosphatase-beta isoforms during development and regeneration of neural tissues
    Andreas Faissner
    Department of Cell Morphology and Molecular Neurobiology, Ruhr University, Bochum, Germany
    Adv Exp Med Biol 557:25-53. 2006
    ..is DSD-1-PG/phosphacan, a glial derived proteoglycan which represents a splice variant of the receptor protein tyrosine phosphatase (RPTP)-beta (also known as PTP-zeta)...
  76. ncbi The receptor-type protein tyrosine phosphatase J antagonizes the biochemical and biological effects of RET-derived oncoproteins
    Angela Iervolino
    Naples Oncogenomic Center Centro di Ricerca per l Ingegneria Genetica, Biotecnologie Avanzate, Italy
    Cancer Res 66:6280-7. 2006
    ..We showed previously that the expression of the receptor-type protein tyrosine phosphatase J (PTPRJ) is suppressed in neoplastically transformed follicular thyroid cells...
  77. pmc SHP-2 positively regulates myogenesis by coupling to the Rho GTPase signaling pathway
    Maria I Kontaridis
    Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520, USA
    Mol Cell Biol 24:5340-52. 2004
    ..We show here that the SH2-containing protein tyrosine phosphatase, SHP-2, functions as an early modulator of myogenesis by regulating RhoA...
  78. ncbi Expression and localization of the Mycobacterium tuberculosis protein tyrosine phosphatase PtpA
    Siobhán C Cowley
    Department of Medicine, University of British Columbia, Vancouver, Canada
    Res Microbiol 153:233-41. 2002
    ..We also show that, despite the lack of a general export pathway signal sequence, the M. tuberculosis PtpA protein can be released from both M. tuberculosis and M. smegmatis during growth...
  79. ncbi A single nucleotide polymorphism in protein tyrosine phosphatase PTP-1B is associated with protection from diabetes or impaired glucose tolerance in Oji-Cree
    Andrea Mok
    John P Robarts Research Institute, London, Ontario, Canada N6A 5K8
    J Clin Endocrinol Metab 87:724-7. 2002
    Several lines of evidence support a role for protein tyrosine phosphatase 1B (PTP-1B) in metabolism, and specifically in insulin sensitivity and obesity...
  80. ncbi SHP-2 regulates the phosphatidylinositide 3'-kinase/Akt pathway and suppresses caspase 3-mediated apoptosis
    Christina Ivins Zito
    Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06520 8066, USA
    J Cell Physiol 199:227-36. 2004
    ..Taken together, these data indicate that the catalytic activity of SHP-2 is required to regulate the PI3K/Akt pathway and thus likely participates in anti-apoptotic signaling by suppressing caspase 3-mediated apoptosis...
  81. pmc Dynamic regulation of pro- and anti-inflammatory cytokines by MAPK phosphatase 1 (MKP-1) in innate immune responses
    Hongbo Chi
    Section of Immunobiology, Department of Pharmacology, and Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 103:2274-9. 2006
    ..These results highlight the complex mechanisms by which the MAPKs regulate innate immunity...
  82. ncbi Receptor-type protein tyrosine phosphatase zeta as a component of the signaling receptor complex for midkine-dependent survival of embryonic neurons
    Nahoko Sakaguchi
    Department of Biochemistry, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Neurosci Res 45:219-24. 2003
    ..Receptor-type protein tyrosine phosphatase zeta (PTP zeta) is a chondroitin sulfate proteoglycan with a transmembrane domain and intracellular ..
  83. ncbi Eph receptors are negatively controlled by protein tyrosine phosphatase receptor type O
    Takafumi Shintani
    Division of Molecular Neurobiology, National Institute for Basic Biology, 5 1 Higashiyama, Myodaiji cho, Okazaki 444 8787, Japan
    Nat Neurosci 9:761-9. 2006
    ..Here, we identified protein tyrosine phosphatase receptor type O (Ptpro) as a specific PTP that efficiently dephosphorylates both EphA and EphB ..
  84. pmc The structure of the cell cycle protein Cdc14 reveals a proline-directed protein phosphatase
    Christopher H Gray
    Section of Structural Biology, Institute of Cancer Research, Chester Beatty Laboratories, 237 Fulham Road, London SW3 6JB, UK
    EMBO J 22:3524-35. 2003
    ..Our structural and kinetic data support a role for Cdc14 in the preferential dephosphorylation of proteins modified by proline-directed kinases...
  85. ncbi Pasticcino2 is a protein tyrosine phosphatase-like involved in cell proliferation and differentiation in Arabidopsis
    Yannick Bellec
    Laboratoire de Biologie Cellulaire, INRA, Route de St Cyr, 78026 Versailles Cedex, France
    Plant J 32:713-22. 2002
    ..PAS2 encodes the Arabidopsis member of the protein tyrosine phosphatase-like (Ptpl) family, a new PTP family originally described in mice and humans and characterized by a ..
  86. ncbi Low molecular weight protein tyrosine phosphatases: small, but smart
    G Raugei
    Dipartimento di Scienze Biochimiche, Firenze, Italy
    Cell Mol Life Sci 59:941-9. 2002
    ..Furthermore, studies on the redox state of LMW-PTP in contact-inhibited cells and in mature myoblasts suggest that LMW-PTP is a general and versatile modulator of growth inhibition...
  87. pmc Protein tyrosine phosphatase 1B negatively regulates macrophage development through CSF-1 signaling
    Krista M Heinonen
    Division of Experimental Medicine, McGill University, Montreal, QC, Canada H3G 1Y6
    Proc Natl Acad Sci U S A 103:2776-81. 2006
    b>Protein tyrosine phosphatase 1B (PTP-1B) is a ubiquitously expressed cytosolic phosphatase with the ability to dephosphorylate JAK2 and TYK2, and thereby down-regulate cytokine receptor signaling...
  88. pmc Receptor protein tyrosine phosphatase gamma is a marker for pyramidal cells and sensory neurons in the nervous system and is not necessary for normal development
    Smaragda Lamprianou
    Institut Pasteur, Department of Neuroscience, 25 rue du Dr Roux, 75724 Paris, France
    Mol Cell Biol 26:5106-19. 2006
    In order to gain insight into the biological role of receptor protein tyrosine phosphatase gamma (RPTPgamma), we have generated RPTPgamma-null mice...
  89. ncbi Roles of Gab1 and SHP2 in paxillin tyrosine dephosphorylation and Src activation in response to epidermal growth factor
    Yuan Ren
    Molecular Oncology Program, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA
    J Biol Chem 279:8497-505. 2004
    ....
  90. pmc Glucocorticoids induce rapid up-regulation of mitogen-activated protein kinase phosphatase-1 and dephosphorylation of extracellular signal-regulated kinase and impair proliferation in human and mouse osteoblast cell lines
    Y Engelbrecht
    Endocrinology and Metabolism Unit, Department of Internal Medicine, University of Stellenbosch, Tygerberg 7505, Cape Town, South Africa
    Endocrinology 144:412-22. 2003
    ..was up-regulated by Dex treatment, and inhibition of ERK activity by Dex was also reversed by the protein tyrosine phosphatase inhibitor, vanadate...
  91. ncbi Genetic evidence for lineage-related and differentiation stage-related contribution of somatic PTPN11 mutations to leukemogenesis in childhood acute leukemia
    Marco Tartaglia
    Dipartimento di Biologia Cellulare e Neuroscienze, Istituto Superiore di Sanita, Viale Regina Elena, 299 00161 Rome, Italy
    Blood 104:307-13. 2004
    SHP-2 is a protein tyrosine phosphatase functioning as signal transducer downstream to growth factor and cytokine receptors...
  92. ncbi Association of protein tyrosine phosphatase 1B gene polymorphisms with type 2 diabetes
    Jennifer L Bento
    Department of Biochemistry, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Diabetes 53:3007-12. 2004
    The PTPN1 gene codes for protein tyrosine phosphatase 1B (PTP1B) (EC 3.1.3.48), which negatively regulates insulin signaling by dephosphorylating the phosphotyrosine residues of the insulin receptor kinase activation segment...
  93. pmc Stimulated initiation of mitogen-activated protein kinase phosphatase-1 (MKP-1) gene transcription involves the synergistic action of multiple cis-acting elements in the proximal promoter
    Stephan Ryser
    Fondation pour Recherche Médicales, University of Geneva, 64 av de la Roseraie, 1211 Geneva, Switzerland
    Biochem J 378:473-84. 2004
    ..Biol. Chem. 276, 33319-33327]...
  94. pmc A baculovirus-encoded protein tyrosine phosphatase gene induces enhanced locomotory activity in a lepidopteran host
    Shizuo G Kamita
    Department of Entomology, University of California, 1 Shields Avenue, Davis, CA 95616, USA
    Proc Natl Acad Sci U S A 102:2584-9. 2005
    ..1997) Oecologia 109, 219-228]. Here we show that a baculovirus-encoded protein tyrosine phosphatase (PTP) gene (ptp) induces ELA that is activated by light...
  95. ncbi Fragment screening and assembly: a highly efficient approach to a selective and cell active protein tyrosine phosphatase 1B inhibitor
    Gang Liu
    Metabolic Disease Research and Advanced Technology, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, Illinois 60064 6098, USA
    J Med Chem 46:4232-5. 2003
    ..site and the second phosphotyrosine binding site, we have identified a small-molecule inhibitor of protein tyrosine phosphatase 1B with low micromolar inhibition constant, high selectivity (30-fold) over the highly homologous T-..
  96. ncbi Protein tyrosine phosphatase-1B gene PTPN1: selection of tagging single nucleotide polymorphisms and association with body fat, insulin sensitivity, and the metabolic syndrome in a normal female population
    Nicola J Spencer-Jones
    Department of Clinical Developmental Sciences, St George s, University of London, London, UK
    Diabetes 54:3296-304. 2005
    b>Protein tyrosine phosphatase-1B negatively regulates leptin and insulin signaling, potentially contributing to hormonal resistance...
  97. ncbi Association of the PTPN22*R620W polymorphism with autoimmune myasthenia gravis
    Claire Vandiedonck
    Institut National de la Sante et de la Recherche Medicale, Universite Paris Descartes, France
    Ann Neurol 59:404-7. 2006
    ..Our objective was to investigate a role of the intracellular tyrosine phosphatase PTPN22*R620W variant in autoimmune myasthenia gravis (MG), considering disease heterogeneity...
  98. ncbi Evaluating the role of the 620W allele of protein tyrosine phosphatase PTPN22 in Crohn's disease and multiple sclerosis
    Philip L De Jager
    Center for Neurologic Diseases, Department of Neurology, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA 02115, USA
    Eur J Hum Genet 14:317-21. 2006
    ....
  99. ncbi Protein tyrosine phosphatases in the human genome
    Andres Alonso
    Program of Signal Transduction, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Cell 117:699-711. 2004
    ..Here, we present the set of 107 genes in the human genome that encode members of the four protein tyrosine phosphatase (PTP) families...
  100. ncbi An Shp2/SFK/Ras/Erk signaling pathway controls trophoblast stem cell survival
    Wentian Yang
    Cancer Biology Program, Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
    Dev Cell 10:317-27. 2006
    ..Bim depletion substantially blocks apoptosis and significantly restores Shp2 null TS cell proliferation, thereby establishing a key mechanism by which FGF4 controls stem cell survival...
  101. ncbi SHP-2 tyrosine phosphatase as an intracellular target of Helicobacter pylori CagA protein
    Hideaki Higashi
    Division of Molecular Oncology, Institute for Genetic Medicine and Graduate School of Science, Hokkaido University, Sapporo 060 0815, Japan
    Science 295:683-6. 2002
    ..Conversely, the CagA effect on cells was reproduced by constitutively active SHP-2. Thus, upon translocation, CagA perturbs cellular functions by deregulating SHP-2...

Research Grants75

  1. Osteoclastic Protein-Tyrosine Phosphatase and Resorption
    Kin Hing William Lau; Fiscal Year: 2013
    ..This project may allow disclose novel targets for development of more effective anti-resorptive therapies for osteoporosis and related disease. Thus, this project is highly relevant to the VA patient care mission. ..
  2. MECHANISM OF ENDOTOXIN ABSORPTION IN ALCOHOLISM
    Radhakrishna Rao; Fiscal Year: 2013
    ..of this acetaldehyde-induced disruption of epithelial barrier function involves inhibition of a protein tyrosine phosphatase, PTP1B, tyrosine phosphorylation of junctional proteins, disruption of the interactions among the ..
  3. Mechanisms for the Effects of Hypothalamic PTP1B on Energy Balance
    KARYN JOANNE CATALANO; Fiscal Year: 2010
    ..Leptin undergoes negative regulation by the ubiquitously expressed protein tyrosine phosphatase PTP1B, suggesting that PTP1B may be a useful target for drug therapy in leptin resistance...
  4. GPCR Signaling &Vascular Wall Remodeling
    Gadiparthi N Rao; Fiscal Year: 2013
    ..that thrombin activates GRB2-associated binding protein 1 (Gab1) and Src homology 2- containing protein tyrosine phosphatase (Shp2), whose stimulation is otherwise expected in response to EGFR activation by its true ligand, EGF, ..
  5. Multiple Molecular Mechanisms for Adiponectin Therapy in Hepatic Fibrogenesis
    Frank A Anania; Fiscal Year: 2013
    ..Preliminary data reveal adiponectin prevents phosphorylation of FAK by the protein tyrosine phosphatase, SHP-2;and adiponectin prevents FA assembly both in vitro and in vivo...
  6. Novel anti-toxin compounds against Yersinia infections
    Maurizio Pellecchia; Fiscal Year: 2010
    ..Yersinae use a number of toxins to evade the immune system one of which is the protein tyrosine phosphatase YopH...
  7. Tie2 Activation for the Treatment of Chemical-Induced Acute Lung Injury
    Christopher D Kontos; Fiscal Year: 2013
    ..In addition to Ang-2, Tie2 is negatively regulated by vascular endothelial protein tyrosine phosphatase (VE-PTP)...
  8. Molecular mechanism of diet induced carcinogenesis
    Samson T Jacob; Fiscal Year: 2013
    ..In the last granting period, we showed that the gene encoding protein tyrosine phosphatase O (PTPRO) is methylated and silenced in preneoplastic nodules and primary hepatomas induced in a rat ..
  9. Role of a new polyomavirus in Merkel cell carcinoma
    Patrick S Moore; Fiscal Year: 2013
    ..One cellular integration site has been defined as the receptor-type protein tyrosine phosphatase-gamma (PTPRG) intron 1. MCPyV also expresses a highly conserved T antigen in tumors...
  10. Small Molecule Inhibitors for the Oncogenic Protein Tyrosine Phosphatase SHP2
    Zhong Yin Zhang; Fiscal Year: 2013
    ..In addition, potent and selective SHP2 inhibitors will also serve as powerful research tools to delineate the function of SHP2 in normal physiology and to elucidate the events underlying SHP2-evoked transformation. ..
  11. The role of PTP1B in leptin receptor-dependent and -independent regulation of ene
    Ryan Tsou; Fiscal Year: 2013
    ..Mice with a mutation in the gene encoding leptin (ob/ob) are obese and diabetic. Protein tyrosine phosphatase 1B (PTP1B) has been shown to negatively regulate leptin signaling, and whole body and brain-specific ..
  12. T1D:Investigating the Gut Microbiome, Urinary Proteome and Metabolome
    Ramana Madupu; Fiscal Year: 2011
    ..Genetic susceptibility traits for T1D are becoming more numerous, including loci for HLA, insulin, protein tyrosine phosphatase-22, cytotoxic T-lymphocyte-associated protein 4, the interleukin-2 receptor and C- type lectin...
  13. The role of TC-PTP in skin carcinogenesis
    Dae Joon Kim; Fiscal Year: 2013
    ..However, recently we have discovered that T-cell protein tyrosine phosphatase (TC-PTP) is activated following UVB or chemical exposure...
  14. MECHANISMS OF ACTIVATION OF ICE-LIKE CYSTEINE PROTEASES
    Emad S Alnemri; Fiscal Year: 2012
    ..The results of this research will help in the design and discovery of effective therapeutics to treat inflammation associated with aging, auto-inflammatory disease and chronic inflammatory diseases. ..
  15. Mechanisms of receptor protein tyrosine phosphatase signaling in Drosophila devel
    Jessica E Treisman; Fiscal Year: 2013
    ....
  16. Role of Shp2 in FLT3-ITD-Induced Leukemogenesis
    Reuben Kapur; Fiscal Year: 2013
    ..Expression of the Shp2 protein tyrosine phosphatase is consistently elevated in primary leukemia cell specimens from multiple adult acute leukemias ..
  17. Role of adipose protein-tyrosine phosphatase 1B in glucose homeostasis and body m
    FAWAZ GEORGE HAJ; Fiscal Year: 2013
    ..Therefore, understanding how adipose PTP1B acts is vital for its evaluation of use as a target for therapeutic intervention. ..
  18. Inhibitors of Mycobacterial Protein Tyrosine Phosphatase B (mPTPB) for therapy of
    Francis Burrows; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Inhibitors of Mycobacterial Protein Tyrosine Phosphatase B (mPTPB) for therapy of tuberculosis Aarden Pharmaceuticals Project Summary/Abstract The need exists for a new, breakthrough therapeutic for ..
  19. Regulation of energy metabolism by an osteoblast-specific gene
    Gerard Karsenty; Fiscal Year: 2010
    ..Esp encodes a protein tyrosine phosphatase expressed in osteoblasts and in Sertoli cells of the testis...
  20. Impact of genetic variation TLR/CD14 pathways and smoking in RA
    TED RICHARD MIKULS; Fiscal Year: 2011
    ..In addition to genetic polymorphisms of CD14/TLR genes, factors to be studied will include SE and protein tyrosine phosphatase (PTPN22), well characterized risk factors for RA...
  21. Function of SHP-1 in oligodendrocytes
    Paul T Massa; Fiscal Year: 2013
    ..Further, we have identified that the protein tyrosine phosphatase SHP-1 is a critical regulator of ROS production in oligodendrocytes and oxidative damage to myelin...
  22. Cell-Cell Signaling in Embryonic and Retinal Development
    Ilaria Rebay; Fiscal Year: 2011
    ..Specifically Eyes absent (Eya), through its unusual dual functionality as transcription factor and protein tyrosine phosphatase (PTP), has the potential both to respond to upstream signaling inputs by directing downstream patterns ..
  23. Role of PTPN11 Mutations in Myeloid Leukemogenesis
    Kevin M Shannon; Fiscal Year: 2010
    ..PTPN11 is thus the first human oncogene encoding a protein tyrosine phosphatase. Murine Ptpn11 mutant embryos succumb in utero with hematopoietic defects...
  24. PTP mu Supresses Brain Tumor Cell Migration and Dispersal
    Susann M Brady Kalnay; Fiscal Year: 2010
    ..PTPu is a cell surface receptor protein tyrosine phosphatase (RPTP) that is expressed in glial cells...
  25. DNA Methylation & Chromatin Modifications: Mechanisms & Applications in Cancer*
    Samson T Jacob; Fiscal Year: 2010
    ..Project 3 will explore the methylation and suppression of the receptor-type protein tyrosine phosphatase (PTPRO) in CLL, PTPRO promoter methylation and reduced expression in genetic subtypes of CLL, the novel ..
  26. Mechanisms of Neuropeptides Action in Diabetes
    JANICE ZABOLOTNY; Fiscal Year: 2013
    ..with the diabetes-induced pro-inflammatory state lead to increased expression and activity of protein tyrosine phosphatase 1B (PTP1B) causing reduced growth factor signaling, reduced fibroblast function and impaired wound ..
  27. Tyrosine Phosphorylation in Alzheimer's Disease
    Gloria Lee; Fiscal Year: 2013
    ..Microtubule binding was not involved. In addition, we found that tau associated with the protein tyrosine phosphatase SHP2 in an NGF-dependent manner...
  28. Nox 4 modulation of NO bioavailability and vascular function
    Siobhan E Craige; Fiscal Year: 2012
    ..modulating eNOS will be characterized and underlying mechanisms probed including Akt, AMP kinase, and protein tyrosine phosphatase 1B...
  29. Shp2 in Osteoclastogenesis and Bone Remodeling
    Wentian Yang; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: We will study the role of protein tyrosine phosphatase Shp2 in osteoclastogenesis and osteoclast functional activation...
  30. Elucidating the function of the widely inactivated phosphatase PTPRD in the molec
    TIMOTHY AN THY CHAN; Fiscal Year: 2013
    ..Recently, our group has shown that the protein tyrosine phosphatase receptor D, PTPRD, is one of the most commonly inactivated tumor suppressors in GBM...
  31. Recep. Protein Tyrosine Phosphatase-k Regulation of EGFR
    Yiru Xu; Fiscal Year: 2013
    ..studies have demonstrated that UV irradiation activates EGFR by oxidative inhibition of receptor-type protein tyrosine phosphatase-kappa (RPTPK), a specific negative regulator of EGFR...
  32. Roles of PTPN11 in regulating and driving epithelial cancer
    Jie Wu; Fiscal Year: 2013
    ..Consequently, there is near complete lack of knowledge about protein tyrosine phosphatase driver oncogenes in lung adenocarcinoma...
  33. A Genetic Model of NMDA Receptor Function in Cell Death
    Michael Lehmann; Fiscal Year: 2013
    ..As a first result of this research, the protein tyrosine phosphatase Ptpmeg was identified as a putative partner of NMDAR in cell death control...
  34. Metabolic Determinants of Cardiovascular Dysfunction in Obesity
    David W Stepp; Fiscal Year: 2013
    ..application, we have generated a novel mouse model in which an insulin receptor desensitizing gene, protein tyrosine phosphatase 1B (PTP1B) is deleted from obese mice...
  35. Inhibition of the Interferon Response by West Nile Virus
    Christoph Seeger; Fiscal Year: 2010
    ..the IFNa receptor complex or if they operate indirectly by activating a cellular antagonist, such as a protein tyrosine phosphatase or other known negative regulators of the IFN response...
  36. Structure/Function of Protein Tyrosine Phosphatases
    Zhong Yin Zhang; Fiscal Year: 2013
    ..This competitive renewal focuses on SHP2 (Src homology 2 (SH2)-domain containing protein tyrosine phosphatase-2), which is the first bona fide oncoprotein identified in the PTP superfamily...
  37. Structural and functional characterization of the receptor protein tyrosine phosp
    Heidi Erlandsen; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: The receptor protein tyrosine phosphatase [unreadable]?? ?(RPTP[unreadable]? ) is a key transmembrane protein that regulates different aspects of ..
  38. Modulation of the Innate Immune System by Fisetin for the Treatment of AD
    PAMELA ANNE MAHER; Fiscal Year: 2013
    ..phenotype by microglia as manifested by an increase in the expression of CD45, a cell surface protein tyrosine phosphatase expressed exclusively by cells of hematopoietic lineages and by inhibition of iNOS induction...
  39. Phosphatase Regulation of Olfactory Bulb Mitral Cell Activity
    Melissa Cavallin Johnson; Fiscal Year: 2011
    ..The specific aims of this proposal are to determine the role of a protein tyrosine phosphatase, SHP-2, in the insulin signaling cascade that regulates Kv1.3 activity in the olfactory bulb...
  40. Imaging Enzyme Structure and Dynamics: Specific Function and Functional Diversity
    Hua Deng; Fiscal Year: 2010
    ..The fruits of this work can lead to more thoroughly understanding disease and then to the discovery of new drugs and methods as well as laboratory diagnostic methods. ..
  41. A NOVEL ROLE FOR PTPN2 IN INTESTINAL EPITHELIAL BARRIER REGULATION
    DECLAN MCCOLE; Fiscal Year: 2013
    ..One such phosphatase, protein tyrosine phosphatase non-receptor type 2 (PTPN2), negatively regulates IFNg signaling in non-epithelial cells...
  42. The Role of RhoA in the Molecular Pathogenesis of Heart Disease
    MARIA IRENE KONTARIDIS; Fiscal Year: 2013
    ..Our proposal will determine whether aberrant regulation of the small GTPase RhoA by the protein tyrosine phosphatase Shp2 is directly involved in mediating IDC pathogenesis...
  43. PI3K Signaling in Juvenile Myelomonocytic Leukemia
    CHARLES B GOODWIN; Fiscal Year: 2013
    ..of the Ras signaling pathway, including activating mutations in PTPN11, which encodes the protein tyrosine phosphatase, Shp2...
  44. STRUCTURAL AND BIOCHEMICAL STUDIES OF PROTEIN TYROSINE PHOSPHATASE FUNCTION
    Samuel Bouyain; Fiscal Year: 2013
    ..this application, we propose to determine the structural basis for the interactions between a receptor protein tyrosine phosphatase called PTPRZ and two of its extracellular binding partners...
  45. Small molecule inhibitors of LMPTP: an obesity drug target
    Nunzio Bottini; Fiscal Year: 2013
    ..This grant focuses on a tyrosine phosphatase called the low molecular weight protein tyrosine phosphatase (LMPTP), encoded by the Acp1 gene...
  46. Genomic alteration of PTPRT in OSCC: Implications for STAT3 pathway targeting
    Noah D Peyser; Fiscal Year: 2013
    ..Preliminary data suggests that the receptor-like protein tyrosine phosphatase T (PTPRT) directly dephosphorylates, and thus inactivates, STAT3 in OSCC preclinical models...
  47. Detecting invading glioma cells through in vivo molecular imaging of the cell sur
    Susann M Brady-Kalnay; Fiscal Year: 2013
    ..PTP[unreadable] is a cell surface receptor protein tyrosine phosphatase (RPTP) and a cell adhesion molecule whose expression is down-regulated in human gliomas...
  48. Targeting bacterial phosphatases for novel anti-bacterial agents.
    Maurizio Pellecchia; Fiscal Year: 2013
    ..and Yersinia enterocolitica use a number of toxins to evade the immune system one of which is the protein tyrosine phosphatase YopH...
  49. Flow Responsive Mediators of Inflammation and Survival
    Chen Yan; Fiscal Year: 2013
    ..1). Recently, SHP2, a protein tyrosine phosphatase (PTPase), was shown to stimulate the Apoptosis Signal-regulated Kinase (ASK1)-JNK-VCAM1 pathway...
  50. Regulation of TCR Signaling by Sts-1 and Sts-2
    NICHOLAS A CARPINO; Fiscal Year: 2013
    ..In our ongoing effort to characterize the functions of the Sts proteins, we recently discovered a novel protein tyrosine phosphatase activity associated with the Sts PGM domain...
  51. Improved Therapies for AML in the Elderly
    SARAH C NABINGER; Fiscal Year: 2011
    ..Tyrosine 599 (Y599) on WT-Flt3 has been shown to recruit the protein tyrosine phosphatase, Shp2, upon Flt3 ligand (FL) stimulation and normally activates the mitogen activated protein kinase, ..
  52. Cell-Cell Signaling in Development and Regeneration of Visual Connections
    John G Flanagan; Fiscal Year: 2013
    ..In recent work, we identified Protein Tyrosine Phosphatase sigma (PTPsigma) as a receptor for CSPGs, opening up new opportunities to study mechanisms in ..
  53. Phosphoinositide Phosphatases
    Jack E Dixon; Fiscal Year: 2013
    The protein tyrosine phosphatase superfamily, all of which contain a highly conserved active site motif, Cys- X5-Arg (CX5R) are key mediators of a wide variety of cellular processes, including growth, metabolism, differentiation, motility,..
  54. Synthesis of phosphono-CheY and phosphono-VHR
    CHRISTOPHER JOHN HALKIDES; Fiscal Year: 2010
    ..b>Protein tyrosine phosphatase enzymes break down phosphoproteins via the creation of a cysteinyl phosphate intermediate that is ..
  55. PTPMT1 Regulates Cancer Cell Bioenergetics by Suppressing Oxidative Metabolism
    NATHAN JAMES LANNING; Fiscal Year: 2013
    ..In a screen to identify genes that regulate metabolism in cancer cells, protein tyrosine phosphatase, mitochondrial 1 (PTPMT1) was found to push cells towards a cancer metabolic program by inhibiting ..
  56. New Treatments of Ocular Neovascularization and Macular Edema
    Peter A Campochiaro; Fiscal Year: 2013
    ..therapy" by keeping Tie2 in an activated state with an antagonist to a specific Tie2 phosphatase, human protein tyrosine phosphatase-b (HPTP-b)...
  57. Receptor PTPs, Cell Contact &Signal Transduction
    Nicholas K Tonks; Fiscal Year: 2013
    ..long-term objectives of the project are to characterize the structure, regulation and function of the protein tyrosine phosphatase (PTP) family of enzymes...
  58. NEUROMODULATION OF THE ANTIBODY RESPONSE
    Virginia M Sanders; Fiscal Year: 2012
    ..affecting class switch recombination (CSR), through a mechanism that appears to inactivate Hematopoetic protein tyrosine phosphatase (HePTP) and enhance p38 MAPK phosphorylation to mediate an increase in ADAM10, which cleaves membrane ..
  59. Novel Protein Phosphatases
    CAROLYN ANN WORBY; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Members of the protein tyrosine phosphatase (PTP) super family contain the highly conserved active site motif, Cys-x5-Arg (Cx5R), and are key mediators of a variety of cellular processes including ..
  60. Role of PTPRkappa in Lck Regulation During T cell Development
    JANE CHERIE YACIUK; Fiscal Year: 2010
    ..This project focuses on how CD4 helper T cells are generated in the thymus. It is hypothesized that protein tyrosine phosphatase receptor kappa (PTPRk), previously shown to be responsible for the defective development of CD4 T cells ..
  61. Protein Tyrosine Dephosphorylation &Signal Transduction
    Nicholas K Tonks; Fiscal Year: 2013
    ..this project are to characterize the structure, regulation and physiological function of members of the protein tyrosine phosphatase (PTP) family of enzymes...
  62. Elucidating the Phosphatase-Independent Roles of PTPN11 in the Heart
    MARIA IRENE KONTARIDIS; Fiscal Year: 2013
    ..Mutations in PTPN11, the gene encoding the protein tyrosine phosphatase (PTP) Shp2, are directly implicated in CHD, causing ~50% of Noonan Syndrome (NS) and nearly all LEOPARD ..
  63. NERVOUS TISSUE GLYCOCONJUGATES
    RICHARD MARGOLIS; Fiscal Year: 2000
    ..in limbic structures the extracellular proteoglycan phosphacan or the full-length receptor-type protein tyrosine phosphatase (RPTP-zeta/beta), of which phosphacan is an alternative splicing variant...
  64. REGULATION OF GRANULOCYTE AND MACROPHAGE PRODUCTION
    E Stanley; Fiscal Year: 2001
    ..4. To analyze to role to protein tyrosine phosphatase-phi in macrophage survival, proliferation and function...
  65. Molecular mechanism of immune evasion by Yersinia pestis
    Tomas Mustelin; Fiscal Year: 2003
    ..component of the molecular machinery by which Yersinia pestis evades the immune system, a highly active protein tyrosine phosphatase (PTPase) termed YopH...
  66. Abnormalities in Keratoconus Corneas
    MARIA KENNEY; Fiscal Year: 2003
    ..We found abnormalities in two distinct signal transduction pathways, (1) a receptor-like protein tyrosine phosphatase (leukocyte common antigen related protein- LAR) and (2) a receptor tyrosine kinase (ErbB3), its ligand (..
  67. TYROSINE PHOSPHORYLATION AT THE NEUROMUSCULAR JUNCTION
    Richard Huganir; Fiscal Year: 1999
    ..protein tyrosine kinases, fyn and fyk, which phosphorylate the AChR and have characterized the major protein tyrosine phosphatase that dephosphorylates the AChR...
  68. REGULATION OF INTERFERON ACTIVITY BY SHP-1 IN THE CNS
    PAUL MASSA; Fiscal Year: 2007
    ..a much higher degree and causes more extensive demyelination in the CNS of mice genetically lacking the protein tyrosine phosphatase SHP-1 compared to wild type mice expressing SHP-1...
  69. Immune Tolerence to Transplanted Myoblasts
    David M Rothstein; Fiscal Year: 2010
    ..will utilize newly emerging strategies that incorporate mAbs against the higher Mr isoforms of the CD45 protein tyrosine phosphatase (anti-CD45RB)...
  70. REGULATION/INSULIN SECRETION BY PROTEIN PHOSPHORYLATION
    John Hutton; Fiscal Year: 2003
    ..We have identified an insulin granule membrane protein tyrosine phosphatase (P.T..P...
  71. Molecular Pathogenesis of the Cardiomyogenic Defects in LEOPARD Syndrome
    MARIA IRENE KONTARIDIS; Fiscal Year: 2010
    SUMMARY: Recently, mutations in the SH2 domain-containing protein tyrosine phosphatase Shp2, have been implicated in cardiac disease...
  72. Role of CD45 in Hematopoiesis and Lymphomagenesis
    Michelle Hermiston; Fiscal Year: 2005
    ..a novel murine model containing a mutation that disrupts the negative regulation of the receptor-like protein tyrosine phosphatase CD45 during dimerization...
  73. Deficiency of SHP-1 expression and function in multiple sclerosis
    Paul T Massa; Fiscal Year: 2010
    Numerous studies have shown that the protein tyrosine phosphatase SHP-1 modulates the expression of proinflammatory genes in leukocytes and glia that have been shown to cause inflammatory demyelination in the CNS...
  74. Global analysis of hnRNPLL-mediated alternative pre-mRNA splicing in lymphocytes.
    Shalini Oberdoerffer; Fiscal Year: 2009
    ..Alternative splicing of the highly abundant transmembrane protein tyrosine phosphatase, CD45, results in multiple isoforms that are expressed in a stage-specific manner during lymphocyte ..
  75. MOLECULAR AND FUNCTIONAL ANALYSIS OF ICA 512
    Pietro De Camilli; Fiscal Year: 2002
    ..Islet Cell Autoantigen (ICA) 512 is a novel member of the receptor protein tyrosine phosphatase (RPTP) family that we have shown to be an intrinsic membrane protein of SGs...