1 alkyl 2 acetylglycerophosphocholine esterase

Summary

Summary: A lipoprotein-associated PHOSPHOLIPASE A2 which modulates the action of PLATELET ACTIVATING FACTOR by hydrolyzing the SN-2 ester bond to yield the biologically inactive lyso-platelet-activating factor. It has specificity for phospholipid substrates with short-chain residues at the SN-2 position, but inactive against long-chain phospholipids. Deficiency in this enzyme is associated with many diseases including ASTHMA, and HYPERCHOLESTEROLEMIA.

Top Publications

  1. pmc Neuroepithelial stem cell proliferation requires LIS1 for precise spindle orientation and symmetric division
    Jessica Yingling
    Departments of Pediatrics and Medicine, Center for Human Genetics and Genomics, UCSD School of Medicine, 9500 Gilman Drive, La Jolla, CA 92098 0627, USA
    Cell 132:474-86. 2008
  2. ncbi Role of lipoprotein-associated phospholipase A2 in atherosclerosis: biology, epidemiology, and possible therapeutic target
    Andrew Zalewski
    Medicine Development Centre, GlaxoSmithKline, Philadelphia, PA, USA
    Arterioscler Thromb Vasc Biol 25:923-31. 2005
  3. ncbi Lipoprotein-associated phospholipase A2 activity is a marker of small, dense LDL particles in human plasma
    Irene Gazi
    Department of Internal Medicine, Medical School, University of Ioannina, Greece
    Clin Chem 51:2264-73. 2005
  4. ncbi Increased LIS1 expression affects human and mouse brain development
    Weimin Bi
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Nat Genet 41:168-77. 2009
  5. ncbi NUDEL is a novel Cdk5 substrate that associates with LIS1 and cytoplasmic dynein
    M Niethammer
    Department of Pathology, Harvard Medical School, 200 Longwood Avenue, Boston, Massachussetts 02115, USA
    Neuron 28:697-711. 2000
  6. pmc Impaired learning and motor behavior in heterozygous Pafah1b1 (Lis1) mutant mice
    R Paylor
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Learn Mem 6:521-37. 1999
  7. ncbi 14-3-3epsilon is important for neuronal migration by binding to NUDEL: a molecular explanation for Miller-Dieker syndrome
    Kazuhito Toyo-oka
    Department of Pediatrics, UCSD Cancer Center, University of California, San Diego School of Medicine, 9500 Gilman Drive, Mailstop 0627, La Jolla, California 92093 0627, USA
    Nat Genet 34:274-85. 2003
  8. pmc Role of dynein, dynactin, and CLIP-170 interactions in LIS1 kinetochore function
    Chin Yin Tai
    University of Massachusetts Medical School, Department of Cell Biology, Worcester, MA 01605, USA
    J Cell Biol 156:959-68. 2002
  9. ncbi Lipoprotein-associated phospholipase A2, high-sensitivity C-reactive protein, and risk for incident ischemic stroke in middle-aged men and women in the Atherosclerosis Risk in Communities (ARIC) study
    Christie M Ballantyne
    Section of Atherosclerosis and Lipoprotein Research, Department of Medicine, Baylor College of Medicine, and Center for Cardiovascular Disease Prevention, Methodist DeBakey Heart Center, Houston, Tex 77030, USA
    Arch Intern Med 165:2479-84. 2005
  10. ncbi A LIS1/NUDEL/cytoplasmic dynein heavy chain complex in the developing and adult nervous system
    S Sasaki
    Shirakawa Institute of Animal Genetics, Odakura Nishigo Nishishirakawa, 961 8061, Fukushima, Japan
    Neuron 28:681-96. 2000

Research Grants

  1. METABOLISM OF PLATELET-ACTIVATING FACTOR
    Diana Stafforini; Fiscal Year: 2008
  2. MAC 1/LFA 1/P150 95 AND PMN LEUKOCYTE FUNCTION
    Christie Ballantyne; Fiscal Year: 2002
  3. Obesity, Inflammation and Thrombosis: LOOK AHEAD
    Christie M Ballantyne; Fiscal Year: 2010
  4. Inflammation and Infection as Risk Factors in Stroke
    Mitchell Elkind; Fiscal Year: 2006
  5. Levels of Inflammatory Markers in Treatment of Stroke
    Mitchell Elkind; Fiscal Year: 2008
  6. Inflammatory and Infectious Burden and Risk of Stroke
    Mitchell Elkind; Fiscal Year: 2008
  7. SYNAPTIC PLASTICITY IN HIPPOCAMPAL EPILEPTOGENESIS
    Gary Clark; Fiscal Year: 2002
  8. CARDIAC VALVE CALCIFICATION
    Emile Mohler; Fiscal Year: 2003
  9. REGULATION OF ENDOTHELIAL NO SYNTHASE BY PHOSPHORYLATION
    MARSHALL CORSON; Fiscal Year: 2003
  10. Rapid protein crystallization by surface mutagenesis
    Zygmunt Derewenda; Fiscal Year: 2004

Detail Information

Publications203 found, 100 shown here

  1. pmc Neuroepithelial stem cell proliferation requires LIS1 for precise spindle orientation and symmetric division
    Jessica Yingling
    Departments of Pediatrics and Medicine, Center for Human Genetics and Genomics, UCSD School of Medicine, 9500 Gilman Drive, La Jolla, CA 92098 0627, USA
    Cell 132:474-86. 2008
    ..Thus, control of symmetric division, essential for neuroepithelial stem cell proliferation, is mediated through spindle orientation determined via LIS1/NDEL1/dynein-mediated cortical microtubule capture...
  2. ncbi Role of lipoprotein-associated phospholipase A2 in atherosclerosis: biology, epidemiology, and possible therapeutic target
    Andrew Zalewski
    Medicine Development Centre, GlaxoSmithKline, Philadelphia, PA, USA
    Arterioscler Thromb Vasc Biol 25:923-31. 2005
    ....
  3. ncbi Lipoprotein-associated phospholipase A2 activity is a marker of small, dense LDL particles in human plasma
    Irene Gazi
    Department of Internal Medicine, Medical School, University of Ioannina, Greece
    Clin Chem 51:2264-73. 2005
    ..We investigated whether Lp-PLA(2) could be a marker of sdLDL in human plasma...
  4. ncbi Increased LIS1 expression affects human and mouse brain development
    Weimin Bi
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Nat Genet 41:168-77. 2009
    ..Collectively, our results show that an increase in LIS1 expression in the developing brain results in brain abnormalities in mice and humans...
  5. ncbi NUDEL is a novel Cdk5 substrate that associates with LIS1 and cytoplasmic dynein
    M Niethammer
    Department of Pathology, Harvard Medical School, 200 Longwood Avenue, Boston, Massachussetts 02115, USA
    Neuron 28:697-711. 2000
    ..Inhibition of Cdk5 modifies NUDEL distribution in neurons and affects neuritic morphology. Our findings point to cross-talk between two prominent pathways that regulate neuronal migration...
  6. pmc Impaired learning and motor behavior in heterozygous Pafah1b1 (Lis1) mutant mice
    R Paylor
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Learn Mem 6:521-37. 1999
    ..The behavioral findings also support the use of the Lis1 mutant mice as a model from human type 1 lissencephaly...
  7. ncbi 14-3-3epsilon is important for neuronal migration by binding to NUDEL: a molecular explanation for Miller-Dieker syndrome
    Kazuhito Toyo-oka
    Department of Pediatrics, UCSD Cancer Center, University of California, San Diego School of Medicine, 9500 Gilman Drive, Mailstop 0627, La Jolla, California 92093 0627, USA
    Nat Genet 34:274-85. 2003
    ..3 deletions...
  8. pmc Role of dynein, dynactin, and CLIP-170 interactions in LIS1 kinetochore function
    Chin Yin Tai
    University of Massachusetts Medical School, Department of Cell Biology, Worcester, MA 01605, USA
    J Cell Biol 156:959-68. 2002
    ..Together, our data suggest a novel role for LIS1 in mediating CLIP-170-dynein interactions and in coordinating dynein cargo-binding and motor activities...
  9. ncbi Lipoprotein-associated phospholipase A2, high-sensitivity C-reactive protein, and risk for incident ischemic stroke in middle-aged men and women in the Atherosclerosis Risk in Communities (ARIC) study
    Christie M Ballantyne
    Section of Atherosclerosis and Lipoprotein Research, Department of Medicine, Baylor College of Medicine, and Center for Cardiovascular Disease Prevention, Methodist DeBakey Heart Center, Houston, Tex 77030, USA
    Arch Intern Med 165:2479-84. 2005
    ..We assessed Lp-PLA2 and C-reactive protein (CRP) levels along with traditional risk factors to examine their relation to ischemic stroke...
  10. ncbi A LIS1/NUDEL/cytoplasmic dynein heavy chain complex in the developing and adult nervous system
    S Sasaki
    Shirakawa Institute of Animal Genetics, Odakura Nishigo Nishishirakawa, 961 8061, Fukushima, Japan
    Neuron 28:681-96. 2000
    ..These results suggest that LIS1 and NUDEL regulate CDHC activity during neuronal migration and axonal retrograde transport in a Cdk5/p35-dependent fashion...
  11. ncbi The effect of darapladib on plasma lipoprotein-associated phospholipase A2 activity and cardiovascular biomarkers in patients with stable coronary heart disease or coronary heart disease risk equivalent: the results of a multicenter, randomized, double-bl
    Emile R Mohler
    University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    J Am Coll Cardiol 51:1632-41. 2008
    ..This study examined the effects of darapladib, a selective lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) inhibitor, on biomarkers of cardiovascular (CV) risk...
  12. ncbi Role of lipoprotein-associated phospholipase A2 in leukocyte activation and inflammatory responses
    Yi Shi
    Department of Surgery, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Atherosclerosis 191:54-62. 2007
    ..To explore the biologic role of Lp-PLA2 in atherosclerosis, we examined its expression and contribution to leukocyte activation under proatherogenic conditions...
  13. ncbi A role for the lissencephaly gene LIS1 in mitosis and cytoplasmic dynein function
    N E Faulkner
    Department of Cell Biology University of Massachusetts Medical School, 377 Plantation Street, Worcester, Massachusetts 01605, USA
    Nat Cell Biol 2:784-91. 2000
    ..We conclude that LIS1 participates in a subset of dynein functions, and may regulate the division of neuronal progenitor cells in the developing brain...
  14. ncbi Anti-inflammatory properties of a platelet-activating factor acetylhydrolase
    L W Tjoelker
    ICOS Corporation, Bothell, Washington 98021, USA
    Nature 374:549-53. 1995
    ....
  15. ncbi Platelet-activating factor acetylhydrolase is mainly associated with electronegative low-density lipoprotein subfraction
    Sonia Benitez
    Servei de Bioquímica and Institut de Recerca, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    Circulation 108:92-6. 2003
    ..Electronegative LDL [LDL(-)], a modified subfraction of LDL present in plasma, induces the release of interleukin-8 and monocyte chemotactic protein-1 from cultured endothelial cells...
  16. ncbi Short- and long-term elevation of autoantibody titers against oxidized LDL in patients with acute coronary syndromes. Role of the lipoprotein-associated phospholipase A2 and the effect of atorvastatin treatment
    Athanasios I Papathanasiou
    Department of Cardiology, School of Medicine, University of Ioannina, 45110 Ioannina, Greece
    Atherosclerosis 196:289-97. 2008
    ..Early atorvastatin treatment prevents both immune responses; however, the clinical significance of this effect remains to be established...
  17. ncbi Disregulated RhoGTPases and actin cytoskeleton contribute to the migration defect in Lis1-deficient neurons
    Stanislav S Kholmanskikh
    Department of Neurology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Neurosci 23:8673-81. 2003
    ..This effect of Lis1 on GTPases does not appear to occur through direct Lis1 binding of Rho, but could involve Lis1 effects on Rho modulatory proteins or on microtubule dynamics...
  18. pmc Inhibition of lipoprotein-associated phospholipase A2 reduces complex coronary atherosclerotic plaque development
    Robert L Wilensky
    Hospital of the University of Pennsylvania, 3400 Spruce Street, 9 Gates, Philadelphia, Pennsylvania 19104, USA
    Nat Med 14:1059-66. 2008
    ....
  19. ncbi Lipoprotein-associated phospholipase A2 adds to risk prediction of incident coronary events by C-reactive protein in apparently healthy middle-aged men from the general population: results from the 14-year follow-up of a large cohort from southern Germany
    Wolfgang Koenig
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Robert Koch Strasse 8, D 89081 Ulm, Germany
    Circulation 110:1903-8. 2004
    ..Chronic inflammation represents an essential feature of the atherosclerotic process. Lipoprotein-associated phospholipase A2 (Lp-PLA2), an enzyme mainly produced by monocytes/macrophages, generates potent proinflammatory products...
  20. ncbi Plasma PAF-acetylhydrolase: an unfulfilled promise?
    Sonia Athina Karabina
    INSERM U525, Universite Pierre et Marie Curie PARIS6, Faculte de Medecine Pierre et Marie Curie, 91, bd de l Hôpital 75634 Paris cedex 13, France
    Biochim Biophys Acta 1761:1351-8. 2006
    ..It is equally possible that the plasma level of PAF-AH is a diagnostic marker of ongoing atherosclerosis...
  21. ncbi Opposing effects of Ndel1 and alpha1 or alpha2 on cytoplasmic dynein through competitive binding to Lis1
    Chong Ding
    Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    J Cell Sci 122:2820-7. 2009
    ..They also help to explain why brain development is particularly sensitive to a decrease in Lis1 levels...
  22. ncbi Inflammation, bioactive lipids and atherosclerosis: potential roles of a lipoprotein-associated phospholipase A2, platelet activating factor-acetylhydrolase
    Alexandros D Tselepis
    Department of Chemistry, University of Ioannina, 45110, Ioannina, Greece
    Atheroscler Suppl 3:57-68. 2002
    ....
  23. pmc Influence of race and sex on lipoprotein-associated phospholipase A2 levels: observations from the Dallas Heart Study
    Emmanouil S Brilakis
    The Donald W Reynolds Cardiovascular Clinical Research Center at the University of Texas Southwestern Medical Center in Dallas, TX, United States
    Atherosclerosis 199:110-5. 2008
    ..Most lipoprotein-associated phospholipase A2 (Lp-PLA2) studies included mainly white men. We sought to determine whether Lp-PLA2 levels differ according to race and sex...
  24. pmc A role for cytoplasmic dynein and LIS1 in directed cell movement
    Denis L Dujardin
    College of Physicians and Surgeons, Department of Pathology, Columbia University, P and S 15 409, 630 W 168th St, New York, NY 10032, USA
    J Cell Biol 163:1205-11. 2003
    ..Together, these results implicate a leading edge cortical pool of dynein in both early and persistent steps in directed cell movement...
  25. ncbi Platelet-activating factor and related lipid mediators
    S M Prescott
    The Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah 84112, USA
    Annu Rev Biochem 69:419-45. 2000
    ....
  26. pmc LIS1 and NDEL1 coordinate the plus-end-directed transport of cytoplasmic dynein
    Masami Yamada
    Department of Genetic Disease Research, Osaka City University Graduate School of Medicine, Osaka, Japan
    EMBO J 27:2471-83. 2008
    ....
  27. ncbi Fenofibrate induces HDL-associated PAF-AH but attenuates enzyme activity associated with apoB-containing lipoproteins
    Vasilis Tsimihodimos
    Department of Internal Medicine, University of Ioannina, 45110 Ioannina, Greece
    J Lipid Res 44:927-34. 2003
    ....
  28. ncbi Review of the evidence for the clinical utility of lipoprotein-associated phospholipase A2 as a cardiovascular risk marker
    Marshall A Corson
    Division of Cardiology, Department of Medicine, University of Washington, 325 9th Avenue, Seattle, WA 98104, USA
    Am J Cardiol 101:41F-50F. 2008
    ..Ultimately, Lp-PLA(2) may also be classified as a risk factor, but this should not detract from its utility today as a risk marker...
  29. ncbi Cardiovascular events with increased lipoprotein-associated phospholipase A(2) and low high-density lipoprotein-cholesterol: the Veterans Affairs HDL Intervention Trial
    Sander J Robins
    Framingham Heart Study, 73 Mt Wayte Avenue, Framingham, MA 01702, USA
    Arterioscler Thromb Vasc Biol 28:1172-8. 2008
    ..We sought to determine whether increased Lp-PLA(2) would also predict CV events in the absence of high LDL-cholesterol (LDL-C), in a population with low high-density lipoprotein-cholesterol (HDL-C)...
  30. ncbi The cellular roles of the lissencephaly gene LIS1, and what they tell us about brain development
    Richard B Vallee
    Department of Pathology and Cell Biology, Center for Neurobiology and Behavior, Columbia University College of Physicians and Surgeons, New York, New York 10032 USA
    Genes Dev 20:1384-93. 2006
  31. ncbi Graded reduction of Pafah1b1 (Lis1) activity results in neuronal migration defects and early embryonic lethality
    S Hirotsune
    Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Genet 19:333-9. 1998
    ..The phenotypes observed are distinct from those of other mouse mutants with neuronal migration defects, suggesting that Pafah1b1 participates in a novel pathway for neuronal migration...
  32. pmc The association between lipoprotein-associated phospholipase A2 and cardiovascular disease and total mortality in vascular medicine patients
    Matthew A Allison
    Department of Family and Preventive Medicine, University of California, San Diego, CA, USA
    J Vasc Surg 46:500-6. 2007
    ..We tested the hypothesis that Lp-PLA(2) is independently predictive of mortality in high-risk patients from a vascular laboratory...
  33. ncbi LIS1 is a microtubule-associated phosphoprotein
    T Sapir
    Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot, Israel
    Eur J Biochem 265:181-8. 1999
    ..In vitro, LIS1 was phosphorylated by protein kinase CKII (casein kinase II), but not many other kinases that were tested. We suggest that LIS1 activity may be regulated by phosphorylation...
  34. ncbi Lipoprotein-associated phospholipase A2 (platelet-activating factor acetylhydrolase) and cardiovascular disease
    Muriel J Caslake
    Department of Pathological Biochemistry, Glasgow Royal Infirmary, Glasgow, UK
    Curr Opin Lipidol 14:347-52. 2003
    ..This review addresses the molecular properties of Lp-PLA(2), the controversy surrounding its role in atherosclerosis and the regulation of its plasma levels in humans...
  35. ncbi NudC associates with Lis1 and the dynein motor at the leading pole of neurons
    J P Aumais
    Department of Molecular Biology, Baylor College of Medicine, and M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Neurosci 21:RC187. 2001
    ..These data suggest a biochemical and functional interaction of NudC with Lis1 and the dynein motor complex during neuronal migration in vivo...
  36. ncbi Cloning and expression of a cDNA encoding the beta-subunit (30-kDa subunit) of bovine brain platelet-activating factor acetylhydrolase
    M Hattori
    Department of Health Chemistry, Faculty of Pharmaceutical Sciences, University of Tokyo, Japan
    J Biol Chem 270:31345-52. 1995
    ..Combined with our previous data, the present study demonstrated that bovine brain PAF acetylhydrolase Ib is a unique enzyme possessing two catalytic subunits and another, possibly regulatory, subunit...
  37. ncbi Molecular basis of the interaction between plasma platelet-activating factor acetylhydrolase and low density lipoprotein
    D M Stafforini
    Huntsman Cancer Institute, Program in Human Molecular Biology and Genetics, Eccles Institute of Human Genetics, Salt Lake City, Utah 84112, USA
    J Biol Chem 274:7018-24. 1999
    ..These data on the molecular basis of the PAF acetylhydrolase-LDL association provide a new level of understanding regarding the pathway for the catabolism of PAF in human blood...
  38. ncbi Recombinant platelet-activating factor acetylhydrolase to prevent acute respiratory distress syndrome and mortality in severe sepsis: Phase IIb, multicenter, randomized, placebo-controlled, clinical trial
    Daniel P Schuster
    Washington University School of Medicine, St Louis, MO, USA
    Crit Care Med 31:1612-9. 2003
    ....
  39. ncbi Lipoprotein-associated phospholipase A2 as an independent predictor of coronary heart disease. West of Scotland Coronary Prevention Study Group
    C J Packard
    Department of Pathological Biochemistry, Glasgow Royal Infirmary, Scotland
    N Engl J Med 343:1148-55. 2000
    ....
  40. ncbi N-linked glycosylation of macrophage-derived PAF-AH is a major determinant of enzyme association with plasma HDL
    A D Tselepis
    Laboratory of Biochemistry, Department of Chemistry, University of Ioannina, 45110 Ioannina, Greece
    J Lipid Res 42:1645-54. 2001
    ....
  41. ncbi Potential mechanisms of mutations that affect neuronal migration in man and mouse
    C A Walsh
    Division of Neurogenetics, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, Boston, Massachusetts 02115, USA
    Curr Opin Genet Dev 10:270-4. 2000
    ..To understand the action of genes that control neuronal migration and the phenotype of corresponding defects, it might be as important to consider the positioning of the nucleus as it is to consider the guidance of the leading process...
  42. pmc Lis1-Nde1-dependent neuronal fate control determines cerebral cortical size and lamination
    Ashley S Pawlisz
    Department of Neurology and Center for Genetic Medicine, Northwestern University Feinberg School of Medicine, 303 E Superior Street, Chicago, IL 60611, USA
    Hum Mol Genet 17:2441-55. 2008
    ..Our data suggest that maintaining the shape and cell-cell interactions of radial glial neuroepithelial progenitors by the Lis1-Nde1 complex is essential for their self renewal during the early phase of corticogenesis...
  43. ncbi The role of cytoplasmic dynein in the human brain developmental disease lissencephaly
    R B Vallee
    University of Massachusetts Medical School, 377 Plantation Street, Worcester, MA 01605, USA
    Biochim Biophys Acta 1496:89-98. 2000
    ....
  44. ncbi Molecular cloning and characterization of the human NUDC gene
    N Matsumoto
    Department of Human Genetics, The University of Chicago, IL 60637, USA
    Hum Genet 104:498-504. 1999
    ..Northern analysis showed a major 1.6 kb transcript in all fetal and adult tissues examined. Primers which amplify individual exons of NUDC were developed for mutation analysis...
  45. ncbi Lissencephaly associated mutations suggest a requirement for the PAFAH1B heterotrimeric complex in brain development
    K J Sweeney
    Max Planck Institute for Experimental Endocrinology, Feodor Lynen Strasse 7, D 30625, Hannover, Germany
    Mech Dev 92:263-71. 2000
    ....
  46. ncbi Lissencephaly gene (LIS1) expression in the CNS suggests a role in neuronal migration
    O Reiner
    Department of Molecular Genetics and Virology, Weizmann Institute of Science, Rehovot, Israel
    J Neurosci 15:3730-8. 1995
    ..The direct correlation between cortical defects in MDS patients and Lis1 expression in the murine cortex suggest that the mouse is a model system suitable to study the mechanistic basis of this intriguing genetic disease...
  47. ncbi Lipoprotein-associated phospholipase A2 as a target of therapy
    Colin H Macphee
    Department of Vascular Biology and Thrombosis, GlaxoSmithKline, King of Prussia, PA 19406, USA
    Curr Opin Lipidol 16:442-6. 2005
    ..Since interest in this enzyme as a putative drug target has been based primarily upon its association with low-density lipoprotein (LDL) in human plasma, this review will focus on Lp-PLA2 and human coronary heart disease...
  48. pmc Lis1 and doublecortin function with dynein to mediate coupling of the nucleus to the centrosome in neuronal migration
    Teruyuki Tanaka
    Department of Neurosciences, University of California, San Diego, La Jolla 92093 0624, USA
    J Cell Biol 165:709-21. 2004
    ..These data indicate Lis1 and Dcx function with dynein to mediate N-C coupling during migration, and suggest defects in this coupling may contribute to migration defects in lissencephaly...
  49. ncbi Ndel1 operates in a common pathway with LIS1 and cytoplasmic dynein to regulate cortical neuronal positioning
    Tianzhi Shu
    Department of Pathology, Harvard Medical School and Howard Hughes Medical Institute, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Neuron 44:263-77. 2004
    ..These results provide strong evidence that Ndel1 interacts with LIS1 to sustain the function of dynein, which in turn impacts microtubule organization, nuclear translocation, and neuronal positioning...
  50. ncbi Biology of platelet-activating factor acetylhydrolase (PAF-AH, lipoprotein associated phospholipase A2)
    Diana M Stafforini
    Huntsman Cancer Institute and Department of Internal Medicine, University of Utah, 2000 Circle of Hope, Suite 3364, Salt Lake City, UT 84112 5550, USA
    Cardiovasc Drugs Ther 23:73-83. 2009
    ..PAF-AH catalyzes the removal of the acyl group at the sn-2 position of PAF and truncated phospholipids generated in settings of inflammation and oxidant stress...
  51. ncbi LIS1 regulates CNS lamination by interacting with mNudE, a central component of the centrosome
    Y Feng
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Neuron 28:665-79. 2000
    ..Moreover, misexpression of the LIS1 binding domain of mNudE in Xenopus embryos disrupts the architecture and lamination of the CNS. Thus, LIS1-mNudE interactions may regulate neuronal migration through dynamic reorganization of the MTOC...
  52. ncbi The epidemiology of Lp-PLA(2): distribution and correlation with cardiovascular risk factors in a population-based cohort
    Margaretha Persson
    Department of Medicine, University Hospital Malmo, Sweden
    Atherosclerosis 190:388-96. 2007
    ..However, the measured variables accounted for only 19% and 35% of the variation in Lp-PLA(2) mass and activity respectively...
  53. ncbi The role of lipoprotein-associated phospholipase A2 in atherosclerosis may depend on its lipoprotein carrier in plasma
    Constantinos C Tellis
    Laboratory of Biochemistry, Department of Chemistry, University of Ioannina, 45110 Ioannina, Greece
    Biochim Biophys Acta 1791:327-38. 2009
    ....
  54. ncbi Regulation of cytoplasmic dynein ATPase by Lis1
    Mariano T Mesngon
    Department of Biological Sciences, University of South Carolina, Columbia, South Carolina 29208, USA
    J Neurosci 26:2132-9. 2006
    ..We propose a model in which Lis1 stimulates the activity of a subset of motors, which could be particularly important during neuronal migration and long-distance axonal transport...
  55. ncbi Coupling PAF signaling to dynein regulation: structure of LIS1 in complex with PAF-acetylhydrolase
    Cataldo Tarricone
    Department of Experimental Oncology, European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy
    Neuron 44:809-21. 2004
    ..Our data suggest that the LIS1 molecule undergoes major conformational rearrangement when switching from a complex with the acetylhydrolase to the one with Ndel1...
  56. ncbi Lissencephaly with cerebellar hypoplasia (LCH): a heterogeneous group of cortical malformations
    M E Ross
    Department of Neurology, University of Minnesota, Minneapolis, MN 55455, USA
    Neuropediatrics 32:256-63. 2001
    ....
  57. ncbi An assessment of incremental coronary risk prediction using C-reactive protein and other novel risk markers: the atherosclerosis risk in communities study
    Aaron R Folsom
    Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN 55454 1015, USA
    Arch Intern Med 166:1368-73. 2006
    ..There has been interest in recent years in whether additional, and in particular novel, risk factors or blood markers, such as C-reactive protein, can enhance existing coronary heart disease (CHD) prediction models...
  58. ncbi Point mutations and an intragenic deletion in LIS1, the lissencephaly causative gene in isolated lissencephaly sequence and Miller-Dieker syndrome
    C Lo Nigro
    Laboratorio di Genetica Molecolare, San Raffaele Hospital, Milan, Italy
    Hum Mol Genet 6:157-64. 1997
    ..These data thus confirm LIS1 as the gene responsible for classical lissencephaly in ILS and MDS...
  59. ncbi Platelet-activating factor acetylhydrolase concentration in children with abdominal obesity
    Tomoo Okada
    Arterioscler Thromb Vasc Biol 26:e40-1. 2006
  60. ncbi Detection and characterization of 45 kDa platelet activating factor acetylhydrolase in cerebrospinal fluid of children with meningitis
    Tae Chul Moon
    College of Pharmacy, Yeungnam University, Gyongsan 712 749, Korea
    Arch Pharm Res 26:554-8. 2003
    ..These results suggested that plasma type PAF-AH activity exist in CSF taken from children with meningitis...
  61. ncbi Lipoprotein-associated phospholipase A2 predicts future cardiovascular events in patients with coronary heart disease independently of traditional risk factors, markers of inflammation, renal function, and hemodynamic stress
    Wolfgang Koenig
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Robert Koch Str 8, D 89081 Ulm, Germany
    Arterioscler Thromb Vasc Biol 26:1586-93. 2006
    ..We sought to evaluate whether lipoprotein-associated phospholipase A2 (Lp-PLA2), an emerging marker of cardiovascular risk, is associated with prognosis in patients with coronary heart disease (CHD)...
  62. ncbi LIS1 missense mutations: variable phenotypes result from unpredictable alterations in biochemical and cellular properties
    Michal Caspi
    Department of Molecular Genetics, Weizmann Institute of Science, 76100 Rehovot, Israel
    J Biol Chem 278:38740-8. 2003
    ..Our results implicate that there are probably different biochemical and cellular mechanisms obstructed in each patient yielding the varied lissencephaly phenotypes...
  63. ncbi The structure of the coiled-coil domain of Ndel1 and the basis of its interaction with Lis1, the causal protein of Miller-Dieker lissencephaly
    Urszula Derewenda
    Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA 22908, USA
    Structure 15:1467-81. 2007
    ....
  64. ncbi High frequency of genomic deletions--and a duplication--in the LIS1 gene in lissencephaly: implications for molecular diagnosis
    D Mei
    Pediatric Neurology and Neurogenetics Unit and Laboratories, Children s Hospital A Meyer, University of Florence, Florence, Italy
    J Med Genet 45:355-61. 2008
    ....
  65. ncbi Lipoprotein-associated phospholipase A2, high-sensitivity C-reactive protein, and risk for incident coronary heart disease in middle-aged men and women in the Atherosclerosis Risk in Communities (ARIC) study
    Christie M Ballantyne
    Section of Atherosclerosis and Lipoprotein Research, Department of Medicine, Baylor College of Medicine, and Methodist DeBakey Heart Center, Houston, Tex 77030, USA
    Circulation 109:837-42. 2004
    ..Lipoprotein-associated phospholipase A2 (Lp-PLA2) is a proinflammatory enzyme associated primarily with LDL...
  66. ncbi Recombinant human platelet-activating factor acetylhydrolase for treatment of severe sepsis: results of a phase III, multicenter, randomized, double-blind, placebo-controlled, clinical trial
    Steven Opal
    Division of Infectious Diseases, Brown Medical School, Providence, RI, USA
    Crit Care Med 32:332-41. 2004
    ..A previous clinical trial with recombinant human PAF-AH (rPAF-AH, Pafase) suggested that this treatment may decrease 28-day all-cause mortality in patients with severe sepsis. The current study was undertaken to confirm this result...
  67. ncbi Miller-Dieker lissencephaly gene encodes a subunit of brain platelet-activating factor acetylhydrolase [corrected]
    M Hattori
    Department of Health Chemistry, Faculty of Pharmaceutical Sciences, University of Tokyo, Japan
    Nature 370:216-8. 1994
    ..Our results raise the possibility that PAF and PAF acetylhydrolase are important in the formation of the brain cortex during differentiation and development...
  68. pmc Reduction of microtubule catastrophe events by LIS1, platelet-activating factor acetylhydrolase subunit
    T Sapir
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
    EMBO J 16:6977-84. 1997
    ..We postulate that the LIS1-cytoskeletal interaction is important for neuronal migration, a process that is defective in lissencephaly patients...
  69. ncbi Recruitment of katanin p60 by phosphorylated NDEL1, an LIS1 interacting protein, is essential for mitotic cell division and neuronal migration
    Kazuhito Toyo-oka
    Department of Genetic Disease Research, Osaka University Graduate School of Medicine, Japan
    Hum Mol Genet 14:3113-28. 2005
    ..Our results suggest that NDEL1 is essential for mitotic cell division and neuronal migration not only via regulation of cytoplasmic dynein function but also by modulation of katanin p60 localization and function...
  70. pmc Lipoprotein-associated phospholipase A2, platelet-activating factor acetylhydrolase, generates two bioactive products during the oxidation of low-density lipoprotein: use of a novel inhibitor
    C H Macphee
    Department of Vascular Biology, SmithKline Beecham Pharmaceuticals, New Frontiers Science Park North, Third Avenue, The Pinnacles, Harlow, Essex CM19 5AW, UK
    Biochem J 338:479-87. 1999
    ..Finally, similar studies have demonstrated that a different situation exists during the oxidation of high-density lipoprotein, with enzyme(s) other than Lp-PLA2 apparently being responsible for generating lysophosphatidylcholine...
  71. ncbi Enhanced expression of Lp-PLA2 and lysophosphatidylcholine in symptomatic carotid atherosclerotic plaques
    Dallit Mannheim
    Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Stroke 39:1448-55. 2008
    ..Therefore, this study was performed to test the hypothesis that Lp-PLA(2) expression is higher in symptomatic than in asymptomatic carotid plaques of patients undergoing carotid endarterectomy...
  72. pmc Platelet-activating factor acetylhydrolase deficiency. A missense mutation near the active site of an anti-inflammatory phospholipase
    D M Stafforini
    Eccles Institute of Human Genetics, University of Utah, Salt Lake City, 84112, USA
    J Clin Invest 97:2784-91. 1996
    ..This mutation as a heterozygous trait is present in 27% in the Japanese population. This finding will allow rapid identification of subjects predisposed to severe asthma and other PAF-mediated disorders...
  73. ncbi Platelet-activating factor acetylhydrolase (PAF-AH)
    Hiroyuki Arai
    Graduate School of Pharmaceutical Sciences, University of Tokyo, Hongo Bunkyo ku, Tokyo 113 0033, Japan
    J Biochem 131:635-40. 2002
    ..In this review, we will focus on the structures and possible biological functions of intracellular PAF-AHs...
  74. ncbi Interaction between LIS1 and doublecortin, two lissencephaly gene products
    M Caspi
    Department of Molecular Genetics, Weizmann Institute of Science, 76100 Rehovot, Israel
    Hum Mol Genet 9:2205-13. 2000
    ..We conclude that LIS1 and DCX cross-talk is important to microtubule function in the developing cerebral cortex...
  75. ncbi Exogenous platelet-activating factor acetylhydrolase reduces mortality in mice with systemic inflammatory response syndrome and sepsis
    Rachel N Gomes
    Laboratorio de Imunofarmacologia, Departamento de Fisiologia e Farmacodinamica, IOC, Fundacao Oswaldo Cruz, Rio de Janeiro, RJ, Brazil
    Shock 26:41-9. 2006
    ..Serial measurements of plasma PAF-AH activity in murine models demonstrate dynamic regulation of the endogenous enzyme, potentially explaining the variations in human subjects...
  76. ncbi Intracellular PAF catabolism by PAF acetylhydrolase counteracts continual PAF synthesis
    Jiawei Chen
    Department of Cell Biology, Cleveland Clinic Lerner College of Medicine, Cleveland Clinic, Cleveland, OH 44195, USA
    J Lipid Res 48:2365-76. 2007
    ....
  77. ncbi The low-density lipoprotein (LDL)-associated PAF-acetylhydrolase activity and the extent of LDL oxidation are important determinants of the autoantibody titers against oxidized LDL in patients with coronary artery disease
    Evangelia S Lourida
    Laboratory of Biochemistry, Department of Chemistry, University of Ioannina, 45110 Ioannina, Greece
    Prostaglandins Leukot Essent Fatty Acids 75:117-26. 2006
    ..Lyso-PC, a major component of oxLDL(P), could be mainly responsible for the elevated autoantibody titers against oxLDL in patients with stable angina...
  78. ncbi Lipoprotein-associated phospholipase A2 activity and risk of heart failure: The Rotterdam study
    Laura C van Vark
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Eur Heart J 27:2346-52. 2006
    ..Lipoprotein-associated phospholipase A2 (Lp-PLA2) has pro-inflammatory properties. We investigated whether Lp-PLA2 activity is associated with heart failure...
  79. ncbi Platelet activating factor (PAF) and activity of its biosynthetic and catabolic enzymes in blood and leukocytes of male patients with newly diagnosed heart failure
    Paraskevi Detopoulou
    Department of Nutrition Science Dietetics, Harokopio University, 70 E1 Venizelou Street, Athens, 17671, Greece
    Clin Biochem 42:44-9. 2009
    ..To evaluate platelet activating factor (PAF) levels, its metabolic enzymes activity and its associations with other inflammatory markers in heart failure (HF) patients...
  80. pmc Refinement of a 400-kb critical region allows genotypic differentiation between isolated lissencephaly, Miller-Dieker syndrome, and other phenotypes secondary to deletions of 17p13.3
    Carlos Cardoso
    Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA
    Am J Hum Genet 72:918-30. 2003
    ....
  81. ncbi Doublecortin functions at the extremities of growing neuronal processes
    Gaelle Friocourt
    Laboratoire de Génétique et Physiopathologie des Retards Mentaux, GDPM, Institut Cochin, 24 rue du Faubourg Saint Jacques, F 75014 Paris, France
    Cereb Cortex 13:620-6. 2003
    ..The observations summarized here favor the suggestion that whereas LIS1 may play a role in nuclear migration, Doublecortin is instead restricted to functions at the leading edge of the cell...
  82. ncbi Altered activities of anti-atherogenic enzymes LCAT, paraoxonase, and platelet-activating factor acetylhydrolase in atherosclerosis-susceptible mice
    Trudy M Forte
    Life Sciences Division MS 1 222, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    J Lipid Res 43:477-85. 2002
    ..We conclude that impairment of LCAT activity and accumulation of oxidized phospholipids are part of an early atherogenic phenotype in these models...
  83. ncbi Neuronal migration
    C Lambert de Rouvroit
    Neurobiology Unit, University of Namur Medical School, 61 rue de Bruxelles, B5000, Namur, Belgium
    Mech Dev 105:47-56. 2001
    ..Finally, pattern formation requires the integrity of the external limiting membrane, defects of which lead to overmigration of neurons in meninges and to human type 2 lissencephaly...
  84. ncbi Impaired proliferation and migration in human Miller-Dieker neural precursors
    Volney L Sheen
    Department of Neurology, Division of Neurogenetics and Howard Hughes Medical Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Ann Neurol 60:137-44. 2006
    ..Thus, the objective of this article was to establish human neural precursor cell lines from postmortem MDS tissue and to characterize the pathological cellular processes that contribute to the human lissencephalic phenotype...
  85. ncbi Association between lipoprotein-associated phospholipase A2 and cardiovascular disease: a systematic review
    Carolina A Garza
    Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA
    Mayo Clin Proc 82:159-65. 2007
    ..To estimate the association between plasma lipoprotein-associated phospholipase A2 (Lp-PLA2) levels and cardiovascular disease (CVD)...
  86. ncbi Functional interplay between LIS1, NDE1 and NDEL1 in dynein-dependent organelle positioning
    Connie Lam
    Faculty of Life Sciences, University of Manchester, Manchester, M13 9PT, UK
    J Cell Sci 123:202-12. 2010
    ..Consistent with this hypothesis, expression of exogenous NDE1 or NDEL1 rescued the effects of LIS1 depletion on Golgi organisation, whereas LIS1 was only partially effective at rescuing the loss of NDE1 and NDEL1...
  87. ncbi A prospective evaluation of lipoprotein-associated phospholipase A(2) levels and the risk of future cardiovascular events in women
    G J Blake
    Center for Cardiovascular Disease Prevention, Boston, Massachusetts 02215, USA
    J Am Coll Cardiol 38:1302-6. 2001
    ..CONCLUSIONS: In contrast to prior data among hyperlipidemic men, the current data suggest that Lp-PLA(2) is not a strong predictor of future cardiovascular risk among unselected women...
  88. ncbi Lipoprotein-associated phospholipase A(2) and atherosclerosis
    Robert L Wilensky
    Cardiovascular Division, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Curr Opin Lipidol 20:415-20. 2009
    ..However, only recently have data emerged demonstrating a role of Lp-PLA2 in development of advanced coronary artery disease. Indeed, Lp-PLA2 may be an important link between lipid homeostasis and the vascular inflammatory response...
  89. ncbi Lipoprotein-associated and secretory phospholipase A2 in cardiovascular disease: the epidemiological evidence
    Wolfgang Koenig
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Albert Einstein Allee, 23, 89081, Ulm, Germany
    Cardiovasc Drugs Ther 23:85-92. 2009
    ..Moreover, Lp-PLA(2) might have similar predictive power for both, incident CHD in initially healthy subjects, as well as for recurrent events in those with clinically manifest atherosclerosis...
  90. ncbi Lissencephaly and LIS1: insights into the molecular mechanisms of neuronal migration and development
    A Wynshaw-Boris
    Departments of Pediatrics and Medicine, UCSD School of Medicine, University of California San Diego, La Jolla, CA, USA
    Clin Genet 72:296-304. 2007
    ....
  91. ncbi Multiple dose-dependent effects of Lis1 on cerebral cortical development
    Michael J Gambello
    Department of Pediatrics and Medicine, University of California, San Diego, La Jolla, California 92093 0627, USA
    J Neurosci 23:1719-29. 2003
    ..These studies reveal the importance of LIS1 levels in orderly cerebral cortical morphogenesis and suggest new insights into the pathogenesis of type I lissencephaly...
  92. ncbi Adenovirus-mediated gene transfer of human platelet-activating factor-acetylhydrolase prevents injury-induced neointima formation and reduces spontaneous atherosclerosis in apolipoprotein E-deficient mice
    R Quarck
    Center for Molecular and Vascular Biology, Department of Experimental Surgery and Anesthesiology, Katholieke Universiteit Leuven, Leuven, Belgium
    Circulation 103:2495-500. 2001
    ..The effect of adenovirus-mediated expression of PAF-AH on injury-induced neointima formation and spontaneous atherosclerosis was studied in apolipoprotein E-deficient mice...
  93. ncbi Elevated Lp-PLA2 levels add prognostic information to the metabolic syndrome on incidence of cardiovascular events among middle-aged nondiabetic subjects
    Margaretha Persson
    Department of Clinical Sciences, Internal Medicine Research Group, University Hospital Malmo, Entrance 33, Level 2, SE 205 02 Malmo, Sweden
    Arterioscler Thromb Vasc Biol 27:1411-6. 2007
    ..To explore potential interrelationships between lipoprotein-associated phospholipase A2 (Lp-PLA2), the metabolic syndrome (MetS), and incident cardiovascular disease (CVD)...
  94. ncbi Phospholipid mediators in the vessel wall: involvement in atherosclerosis
    Ewa Ninio
    INSERM U525, IFR14 Coeur Muscle Vaisseaux and Université P M Curie, Faculte de Medecine, Paris, France
    Curr Opin Clin Nutr Metab Care 8:123-31. 2005
    ....
  95. ncbi Type I platelet-activating factor acetylhydrolase catalytic subunits over-expression induces pleiomorphic nuclei and centrosome amplification
    Noritaka Yamaguchi
    Department of Health Chemistry, Graduate School of Pharmaceutical Sciences, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Genes Cells 12:1153-61. 2007
    ..These results suggest that over-expression of the PAF-AH (I) catalytic subunits induces centrosomal amplification and microtubule disorganization by disturbing intracellular localization of LIS1...
  96. ncbi Prevalence and cluster of cardiometabolic biomarkers in overweight and obese schoolchildren: results from a large survey in southwest Germany
    Gabriele Nagel
    Institute of Epidemiology, Ulm University, Ulm, Germany
    Clin Chem 54:317-25. 2008
    ..Obesity is associated with substantial metabolic changes and subclinical inflammation. We explored associations between body mass index (BMI) and cardiometabolic biomarkers and their clustering in overweight and obese schoolchildren...
  97. doi Factoring PAF in anaphylaxis
    A Wesley Burks
    N Engl J Med 358:79-81. 2008
  98. pmc Lipoprotein-associated phospholipase A2 is an independent predictor of incident coronary heart disease in an apparently healthy older population: the Rancho Bernardo Study
    Lori B Daniels
    Division of Cardiology, Department of Medicine, University of California at San Diego, San Diego, California, USA
    J Am Coll Cardiol 51:913-9. 2008
    ..We examined whether the independent association was apparent in older adults...
  99. ncbi Lp-PLA2 activity and PLA2G7 A379V genotype in patients with diabetes mellitus
    P T E Wootton
    Centre for Cardiovascular Genetics, British Heart Foundation Laboratories, Royal Free and University College London Medical School, Rayne Building, 5 University Street, London WC1E 6JF, UK
    Atherosclerosis 189:149-56. 2006
    ..The association of Lp-PLA2 activity with oxLDL/LDL suggests that Lp-PLA2 may be a modulating factor in the process of atherosclerosis...
  100. ncbi A twin study of heritability of plasma lipoprotein-associated phospholipase A2 (Lp-PLA2) mass and activity
    Livia Lenzini
    Department of Clinical and Experimental Medicine, University of Padova, Italy
    Atherosclerosis 205:181-5. 2009
    ..We investigated heritability of plasma levels (mass) and activity of lipoprotein-associated phospholipase A(2) (Lp-PLA(2))...
  101. pmc Identification of a domain that mediates association of platelet-activating factor acetylhydrolase with high density lipoprotein
    Alison A Gardner
    Huntsman Cancer Institute and Department of Internal Medicine, University of Utah, Salt Lake City, Utah 84112, USA
    J Biol Chem 283:17099-106. 2008
    ..These findings contribute to our understanding of the mechanisms responsible for association of human PAF-AH with HDL and may facilitate future studies aimed at precisely determining the function of PAF-AH in each lipoprotein particle...

Research Grants51

  1. METABOLISM OF PLATELET-ACTIVATING FACTOR
    Diana Stafforini; Fiscal Year: 2008
    ..III. Determine if deletion of PAF-AH alters the severity of necrotizing enterocolitis using animal models. IV. Test the hypothesis that PAF-AH alters atherosclerosis susceptibility using genetically engineered models. ..
  2. MAC 1/LFA 1/P150 95 AND PMN LEUKOCYTE FUNCTION
    Christie Ballantyne; Fiscal Year: 2002
    ..3. Characterize the contribution of each CD11 integrin on the host response to common bacterial and fungal pathogens in vitro and in vivo. ..
  3. Obesity, Inflammation and Thrombosis: LOOK AHEAD
    Christie M Ballantyne; Fiscal Year: 2010
    ....
  4. Inflammation and Infection as Risk Factors in Stroke
    Mitchell Elkind; Fiscal Year: 2006
    ..Nationally recognized experts in stroke epidemiology and basic vascular biology will serve as mentors for these studies. ..
  5. Levels of Inflammatory Markers in Treatment of Stroke
    Mitchell Elkind; Fiscal Year: 2008
    ..abstract_text> ..
  6. Inflammatory and Infectious Burden and Risk of Stroke
    Mitchell Elkind; Fiscal Year: 2008
    ..The cross-sectional associations between inflammatory and infectious markers and quantitative MRI abnormalities will also be assessed. ..
  7. SYNAPTIC PLASTICITY IN HIPPOCAMPAL EPILEPTOGENESIS
    Gary Clark; Fiscal Year: 2002
    ..Experiments are proposed to ascertain the role of these signal transduction mechanisms in the enhanced release of excitatory transmitter by PAF receptor activation. ..
  8. CARDIAC VALVE CALCIFICATION
    Emile Mohler; Fiscal Year: 2003
    ..2. To investigate mechanisms of valve calcification using a cell culture model of calcification. 3. To examine therapeutic strategies to inhibit valve calcification with a bisphosphonate in cell culture. ..
  9. REGULATION OF ENDOTHELIAL NO SYNTHASE BY PHOSPHORYLATION
    MARSHALL CORSON; Fiscal Year: 2003
    ..To determine the mechanotransducers of fluid shear stress to eNOS phosphorylation. Aim 4. To elucidate the regulatory role of eNOS phosphorylation in regenerating endothelial cells in culture and in denuded rat aorta. ..
  10. Rapid protein crystallization by surface mutagenesis
    Zygmunt Derewenda; Fiscal Year: 2004
    ..Funds are requested to further test the general applicability and success rate of this method, and to apply the method to a subset of targets selected for the Structural Genomic Initiative. ..
  11. CELLULAR AND MOLECULAR RESPONSES IN LUNG DISEASE
    Guy Zimmerman; Fiscal Year: 2003
    ..abstract_text> ..
  12. Molecular Mechanisms of Neuronal Migration
    Joseph Gleeson; Fiscal Year: 2006
    ..2) DCX and LIS1 function to regulate nuclear movement during neuronal migration. 3) DCX is regulated by cdk5 during neuronal migration. ..
  13. BIOCHEMISTRY OF PROTEIN PRENYLATION
    Michael Gelb; Fiscal Year: 2002
    ....
  14. Advances in Midbrain/Hindbrain Malformations
    Joseph Gleeson; Fiscal Year: 2005
    ..The information content will be made available on the Internet. Thus this Meeting will serve as a resource for both the scientific and lay community throughout the world. ..
  15. Endotoxin Generated Lipid Second Messengers
    Thomas McIntyre; Fiscal Year: 2006
    ..One non-hydrolyzable LPA analog blocks PPARy function and might define a new class of anti-infiammatory, anti-lipidic agents. ..
  16. Conference on Drug Against Tropical Protozoan Parasites
    Michael Gelb; Fiscal Year: 2002
    ..We consider the poster sessions that occur throughout our meeting to be just as important as the collection of lecture presentations. ..
  17. Coronary Endothelial Function in Humans
    Amir Lerman; Fiscal Year: 2006
    ..The success of this program has the potential to further both the research and mentoring endeavors of patient-oriented investigation and mentoring the next generation of patient-oriented researchers. ..
  18. Chemogenomics to Identify New Molecular Targets in PF
    William Henderson; Fiscal Year: 2006
    ..These studies represent a focused effort using chemogenomics to identify, develop, and validate small molecule inhibitors of AP-1/TGFBeta-driven profibrotic gene expression as novel therapies in PF patients. ..
  19. 5-LIPOXYGENASE PRODUCTS IN ASTHMATIC IMMUNE RESPONSE
    William Henderson; Fiscal Year: 2008
    ..abstract_text> ..
  20. MOLECULAR MECHANISMS OF GRANULE CELL MIGRATION
    MARY HATTEN; Fiscal Year: 2007
    ..This information should broaden our view of the mechanisms that control CNS migrations and of the downstream events important to neuronal differentiation within the neural layers. ..
  21. BIOLOGICAL ACTIVITY OF OXIDIZED PHOSPHOLIPIDS
    Thomas McIntyre; Fiscal Year: 2008
    ..5) all these events are controlled by the oxidized phospholipid phospholipase PAF acetylhydrolase. ..
  22. Human Epilepsy Genetics Neuronal Migration Disorders
    Christopher Walsh; Fiscal Year: 2008
    ..Identifying the genes that cause recessive neuronal migration disorders of the cerebral cortex would be important for understanding normal human brain development and evolution, as well as epilepsy pathogenesis. ..
  23. ApoA-I Helical Domains and Cardiovascular Aging
    JOHN BIELICKI; Fiscal Year: 2005
    ..These studies are relevant for devising novel strategies to combat cardiovascular aging. ..
  24. Hormones and Biomarkers Predicting Stroke in Women
    Sylvia Wassertheil Smoller; Fiscal Year: 2005
    ..abstract_text> ..
  25. Circulating Age-related Lipid Mediators in Thrombosis
    Thomas M McIntyre; Fiscal Year: 2010
    ....
  26. Circle of Willis variability and migraine
    BRETT LEE CUCCHIARA; Fiscal Year: 2010
    ..If this hypothesis is confirmed, this could lead to new treatments based on a better understanding of migraine mechanisms and might help identify patients with migraine who are at risk of stroke. ..
  27. Patient-Oriented Research in Recessive Pediatric Brain Diseases
    Joseph Gleeson; Fiscal Year: 2008
    ....
  28. Genetic Analysis of LIS1 Function in the Mouse
    Anthony Wynshaw Boris; Fiscal Year: 2009
    ....
  29. Social Interaction Defects in DV1l Mutant Mice
    Anthony Wynshaw Boris; Fiscal Year: 2005
    ..abstract_text> ..
  30. Embryonic Development of the Cerebellum
    MARY HATTEN; Fiscal Year: 2007
    ..abstract_text> ..
  31. PRESERVATION OF HDL FUNCTION DURING EARLY ATHEROGENESIS
    JOHN BIELICKI; Fiscal Year: 2002
    ..Moreover, the research will uncover novel mechanisms for preserving HDL/LCAT function that can be utilized therapeutically to fight the onset of cardiovascular disease. ..
  32. Genetic Regulation of Neuronal Migration
    Anthony Wynshaw Boris; Fiscal Year: 2009
    ..Based on our preliminary data, we predict that with LIS1, OCX plays a role in the regulation of dynein motor function, and that regulation of OCX activity via phosphorylation by Cdk5/p35 may be analogous to NUDEL regulation. ..
  33. ABCA1 agonist peptides for therapeutic use
    JOHN BIELICKI; Fiscal Year: 2008
    ..The research is likely to have a high impact on public health, since the therapeutics will be amenable to the widespread treatment of atherosclerosis. [unreadable] [unreadable] [unreadable] [unreadable]..
  34. PATHOBIOLOGY OF MACROVASCULAR DISEASE IN DIABETES
    Alan Chait; Fiscal Year: 2007
    ..abstract_text> ..
  35. The Role of PAF and TLR in NEC
    Michael S Caplan; Fiscal Year: 2010
    ..The proposed studies will elucidate the interactions between PAF and TLR signaling, and clarify whether these pathways play an underlying role in the initiation of neonatal NEC. ..
  36. Molecular Genetics of Cytoplasmic Dyein
    RICHARD BERT VALLEE; Fiscal Year: 2010
    ..The final aim has particular significance for the control of acute viral infection and the design of gene delivery vectors and strategies. ..
  37. VASCULAR GRAFT ATHEROSCLEROSIS
    Yi Shi; Fiscal Year: 2001
    ..Thus this proposal examines putative mechanisms responsible for graft attrition in relation to cellular heterogeneity of the vessel. ..
  38. Risk Burden of Lipoprotein Metabolic Gene Haplotypes
    Jeffrey Anderson; Fiscal Year: 2007
    ..We believe this thorough, novel approach will lead to a major advance in genetic CHD risk assessment, enabling the vision of gene-based medicine for CHD to be realized. [unreadable] [unreadable]..
  39. MULTIPLEX ANALYSIS OF INBORN ERRORS OF METABOLISM
    Michael Gelb; Fiscal Year: 2001
    ..abstract_text> ..
  40. Preparing high resolution membrane protein crystals
    Zygmunt Derewenda; Fiscal Year: 2005
    ..abstract_text> ..
  41. Leukocyte Responses to Endotoxin
    Thomas McIntyre; Fiscal Year: 2005
    ..We anticipate this work will lead to a new class of anti-inflammatory agents. ..
  42. Anti-Inflammatory PAF Acetylhydrolase in Lung Injury
    Katherine Howard; Fiscal Year: 2004
    ..Through the logical design of the proposed studies, novel and important information will be gained that will significantly advance our understanding of the cell biology of this important anti-inflammatory enzyme. ..
  43. Genetic Predictors of Outcome in Acute MI
    Marc Sabatine; Fiscal Year: 2005
    ..Genomic control will be employed to detect and control for population stratification. Interaction terms will be incorporated into regression models to explore gene-environment and pharmacogenomic interactions. ..
  44. BIOCHEMICAL STUDIES OF 14 KDA PHOSPHOLIPASES A2
    Michael Gelb; Fiscal Year: 2006
    ..These studies will contribute to our fundamental understanding of how mammalian cells initiate the eicosanoid cascade. ..
  45. CONFERENCE ON ARTERIOSCLEROSIS AND VASCULAR BIOLOGY
    Trudy Forte; Fiscal Year: 2004
    ..abstract_text> ..
  46. The Role of Filamin in Periventricular Heterotopias
    Volney Sheen; Fiscal Year: 2005
    ....
  47. Neural Tube Defects in Disheveled Mutant Mice
    Anthony Wynshaw Boris; Fiscal Year: 2008
    ..The effect of these mutations on neural tube closure in Dvl -/-Dvl2 -/- mutants will be assessed. ..
  48. AFRICAN AMERICAN ANTIPLATELET STROKE PREVENTION STUDY
    Philip Gorelick; Fiscal Year: 2004
    ..They have currently completed two-thirds of the projected enrollment and should be able to continue to administer this trial competently to its conclusion. ..
  49. GENETICS OF CEREBELLAR AXON FORMATION
    MARY HATTEN; Fiscal Year: 2004
    ..In the BAC transgenic animals we can examine the effect of kinase-deficient neurons on the development of the other cerebellar neurons and glia. ..
  50. ENDOTHELIN IN HUMANS CORONARY IN EARLY ATHEROSCLEROSIS
    Amir Lerman; Fiscal Year: 2003
    ....