Genomes and Genes
carboxylic ester hydrolases
Summary: Enzymes which catalyze the hydrolysis of carboxylic acid esters with the formation of an alcohol and a carboxylic acid anion.
Publications289 found, 100 shown here
- Quenching quorum-sensing-dependent bacterial infection by an N-acyl homoserine lactonaseY H Dong
Institute of Molecular Agrobiology, National University of Singapore, Singapore
Nature 411:813-7. 2001..carotovora infection. Our results highlight a promising potential to use quorum-sensing signals as molecular targets for disease control, thereby broadening current approaches for prevention of bacterial infections...
- New insights into pectin methylesterase structure and functionJérôme Pelloux
Groupe de Génomique Fonctionnelle des Plantes, EA 3900, Faculte des Sciences, Universite de Picardie Jules Verne, 33 rue St Leu, 80039 Amiens, France
Trends Plant Sci 12:267-77. 2007..Although, overall, protein structures are highly conserved between isoforms, recent data indicate that structural variations might be associated with the targeting and functions of specific pectin methylesterases...
- The molecular structure and catalytic mechanism of a quorum-quenching N-acyl-L-homoserine lactone hydrolaseMyung Hee Kim
Korea Research Institute of Bioscience and Biotechnology, Yusong, Daejon 305 600, Korea
Proc Natl Acad Sci U S A 102:17606-11. 2005..We present experimental evidence that AHL-lactonase is a metalloenzyme containing two zinc ions involved in catalysis, and we propose a catalytic mechanism for bacterial metallo-AHL-lactonases...
- Pectin methylesterases: cell wall enzymes with important roles in plant physiologyF Micheli
Laboratoire de Biologie Moleculaire des relations Plantes Microorganismes, INRA CNRS, BP27, 31326 Castanet Tolosan Cedex, France
Trends Plant Sci 6:414-9. 2001....
- A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosomeRicarda Richter
Mitochondrial Research Group, Institute for Ageing and Health, Medical School, Newcastle University, Newcastle upon Tyne, UK
EMBO J 29:1116-25. 2010..We suggest that ICT1 may be essential for hydrolysis of prematurely terminated peptidyl-tRNA moieties in stalled mitoribosomes...
- Pectin-induced changes in cell wall mechanics underlie organ initiation in ArabidopsisAlexis Peaucelle
Institut Jean Pierre Bourgin, UMR1318 INRA AgroParisTech, 78026 Versailles, France
Curr Biol 21:1720-6. 2011....
- Structural basis for natural lactonase and promiscuous phosphotriesterase activitiesMikael Elias
Laboratoire de Cristallographie et Modélisation des Matériaux Minéraux et Biologiques, CNRS Université Henri Poincaré, 54506 Nancy, France
J Mol Biol 379:1017-28. 2008..This example demonstrates that promiscuous activities probably constitute a large and efficient reservoir for the creation of novel catalytic activities...
- Identification of quorum-quenching N-acyl homoserine lactonases from Bacillus speciesYi Hu Dong
Institute of Molecular Agrobiology, National University of Singapore, Singapore 117604
Appl Environ Microbiol 68:1754-9. 2002..Sequence comparison of the gene products and motif analysis showed that the gene products belong to the same family of AHL lactonases...
- Structural basis for the interaction between pectin methylesterase and a specific inhibitor proteinAdele Di Matteo
Department of Biochemical Sciences, University of Rome, 00185 Rome, Italy
Plant Cell 17:849-58. 2005..The structure of the complex gives an insight into the specificity of the inhibitor toward plant PMEs and the mechanism of regulation of these enzymes...
- Microbial carboxyl esterases: classification, properties and application in biocatalysisUwe T Bornscheuer
Institute for Chemistry and Biochemistry, Department of Technical Chemistry and Biotechnology, Greifswald University, Soldmannstr 16, Greifswald, Germany
FEMS Microbiol Rev 26:73-81. 2002..Special emphasis is given on their application in organic synthesis for the resolution of racemates and prostereogenic compounds. In addition, recent results for altering their properties by directed evolution are presented...
- Structure and specificity of a quorum-quenching lactonase (AiiB) from Agrobacterium tumefaciensDali Liu
Department of Chemistry, Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, Massachusetts 02454 9110, USA
Biochemistry 46:11789-99. 2007..This work should help elucidate the hydrolytic ring-opening mechanism of this family of enzymes and also facilitate the design of more effective quorum-quenching catalysts...
- A role for pectin de-methylesterification in a developmentally regulated growth acceleration in dark-grown Arabidopsis hypocotylsSandra Pelletier
Institut Jean Pierre Bourgin, UMR1318 INRA AgroParisTech, INRA Centre de Versailles Grignon, Versailles, France
New Phytol 188:726-39. 2010..This study shows that the acceleration of cell elongation marks a developmental transition in dark-grown hypocotyl cells and supports a role for pectin de-methylesterification in the timing of this event...
- Direct interaction between the Arabidopsis disease resistance signaling proteins, EDS1 and PAD4B J Feys
The Sainsbury Laboratory, John Innes Centre, Colney, Norwich NR4 7UH, UK
EMBO J 20:5400-11. 2001..We propose two functions for EDS1. The first is required early in plant defence, independently of PAD4. The second recruits PAD4 in the amplification of defences, possibly by direct EDS1-PAD4 association...
- Pectin methylesterase and its proteinaceous inhibitor: a reviewRuben P Jolie
Laboratory of Food Technology and Leuven Food Science and Nutrition Research Centre LFoRCe, Department of Microbial and Molecular Systems M2S, Katholieke Universiteit Leuven, Kasteelpark Arenberg 22, PB 2457, B 3001 Leuven, Belgium
Carbohydr Res 345:2583-95. 2010..Remaining research challenges are indicated...
- Overexpression of pectin methylesterase inhibitors in Arabidopsis restricts fungal infection by Botrytis cinereaVincenzo Lionetti
Dipartimento di Biologia Vegetale, Universita di Roma La Sapienza, 00185 Rome, Italy
Plant Physiol 143:1871-80. 2007..The reduced symptoms caused by the fungus on transgenic plants were related to its impaired ability to grow on methylesterified pectins...
- Arabidopsis SENESCENCE-ASSOCIATED GENE101 stabilizes and signals within an ENHANCED DISEASE SUSCEPTIBILITY1 complex in plant innate immunityBart J Feys
Sainsbury Laboratory, John Ines Centre, Norwich NR4 7UH, United Kingdom
Plant Cell 17:2601-13. 2005..These data, combined with evidence for coregulation between individual EDS1 complexes, suggest that dynamic interactions of EDS1 and its signaling partners in multiple cell compartments are important for plant defense signal relay...
- Genetic control of quorum-sensing signal turnover in Agrobacterium tumefaciensHai Bao Zhang
Laboratory of Biosignals and Bioengineering, Institute of Molecular Agrobiology, National University of Singapore, 1 Research Link, Singapore 117604
Proc Natl Acad Sci U S A 99:4638-43. 2002..These data suggest that A. tumefaciens has a sophisticated multicomponent quorum-sensing signal turnover system, allowing the cell to sense a change in growth and adjust cellular activities accordingly...
- Plant protein inhibitors of cell wall degrading enzymesNathalie Juge
Institut Méditerranéen de Recherche en Nutrition, Faculté des Sciences de St Jérôme, F 13397 Marseilles Cedex 20, France
Trends Plant Sci 11:359-67. 2006....
- Different roles of Enhanced Disease Susceptibility1 (EDS1) bound to and dissociated from Phytoalexin Deficient4 (PAD4) in Arabidopsis immunitySteffen Rietz
Department of Plant Microbe Interactions, Max Planck Institute for Plant Breeding Research, Koln, Germany
New Phytol 191:107-19. 2011..Different EDS1 and PAD4 molecular configurations have distinct and separable functions in the plant innate immune response...
- Desnutrin, an adipocyte gene encoding a novel patatin domain-containing protein, is induced by fasting and glucocorticoids: ectopic expression of desnutrin increases triglyceride hydrolysisJosep A Villena
Department of Nutritional Sciences and Toxicology, University of California, Berkeley, California 94720, USA
J Biol Chem 279:47066-75. 2004..In addition, decreased expression of desnutrin in obesity models suggests its possible contribution to the pathophysiology of obesity...
- Orally administered thermostable N-acyl homoserine lactonase from Bacillus sp. strain AI96 attenuates Aeromonas hydrophila infection in zebrafishYanan Cao
Key Laboratory for Feed Biotechnology of the Ministry of Agriculture, Feed Research Institute, Chinese Academy of Agricultural Sciences, Beijing, People s Republic of China
Appl Environ Microbiol 78:1899-908. 2012..This is the first report of the oral administration of an AHL lactonase for the efficient control of A. hydrophila...
- Caterpillar-elicited methanol emission: a new signal in plant-herbivore interactions?Caroline C von Dahl
Department of Molecular Ecology, Max Planck Institute for Chemical Ecology, Beutenberg Campus, Hans Knoll Strasse 8, 07745 Jena, Germany
Plant J 46:948-60. 2006....
- A novel function for a ubiquitous plant enzyme pectin methylesterase: the enhancer of RNA silencingYuri L Dorokhov
Department of Virology and A N Belozersky Institute of Physico Chemical Biology, Moscow State University, Leninsky Gory 1, Laboratory Building A, Moscow 119992, Russia
FEBS Lett 580:3872-8. 2006..It was hypothesized that DCL1 relocated to the cytoplasm may use as substrates both miRNA precursor and viral RNA. The capacity for enhancing the RNA silencing is a novel function for the polyfunctional PME...
- The N-terminal pro region mediates retention of unprocessed type-I PME in the Golgi apparatusSebastian Wolf
Heidelberg Institute for Plant Sciences, INF 360, 69120 Heidelberg, Germany
Plant J 58:361-75. 2009..Consequently, pro-protein processing could constitute a post-translational mechanism regulating PME activity...
- AiiM, a novel class of N-acylhomoserine lactonase from the leaf-associated bacterium Microbacterium testaceumWen Zhao Wang
Department of Material and Environmental Chemistry, Graduate School of Engineering, Utsunomiya University, 7 1 2 Yoto, Utsunomiya 321 8585, Japan
Appl Environ Microbiol 76:2524-30. 2010..carotovorum reduced pectinase activity markedly and attenuated soft rot symptoms on potato slices. In conclusion, this study indicated that AiiM might be effective in quenching quorum sensing of P. carotovorum subsp. carotovorum...
- The Ti plasmid of Agrobacterium tumefaciens harbors an attM-paralogous gene, aiiB, also encoding N-Acyl homoserine lactonase activityA Carlier
Institut des Sciences du Vegetal, Centre National de la Recherche Scientifique, Gif sur Yvette, France
Appl Environ Microbiol 69:4989-93. 2003..In Erwinia strain 6276, the lactonases reduced the endogenous acyl-HSL level and the bacterial virulence in planta...
- AidH, an alpha/beta-hydrolase fold family member from an Ochrobactrum sp. strain, is a novel N-acylhomoserine lactonaseGui Ying Mei
Department of Plant Pathology, China Agricultural University, Beijing 100193, China
Appl Environ Microbiol 76:4933-42. 2010....
- Pectin methylesterases and pectin dynamics in pollen tubesMaurice Bosch
School of Biosciences, University of Birmingham, UK
Plant Cell 17:3219-26. 2005
- AhlD, an N-acylhomoserine lactonase in Arthrobacter sp., and predicted homologues in other bacteriaSun Yang Park
R and D Center, inBioNET Corporation, Daejeon 305 390, Korea
Microbiology 149:1541-50. 2003..Furthermore, it was verified that ahlK, an ahlD homologue, encodes an AHL-degrading enzyme in K. pneumoniae. Accordingly, the current results suggest the possibility that AhlD-like AHLases could exist in many other micro-organisms...
- Human serum paraoxonase (PON 1) is inactivated by oxidized low density lipoprotein and preserved by antioxidantsM Aviram
The Lipid Research Laboratory, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences and Rambam Medical Center, Haifa, Israel
Free Radic Biol Med 26:892-904. 1999..e. prevention of its formation, and removal of Ox-LDL associated oxidized lipids which are generated during LDL oxidation...
- YaeJ is a novel ribosome-associated protein in Escherichia coli that can hydrolyze peptidyl-tRNA on stalled ribosomesYoshihiro Handa
Department of Chemistry and Chemical Biology, Graduate School of Engineering, Gunma University, 1 5 1 Tenjin cho, Kiryu shi, Gunma 376 8515, Japan
Nucleic Acids Res 39:1739-48. 2011..The C-terminal basic residue-rich extension was also found to be required for ribosome binding. These findings suggest that YaeJ functions as a ribosome-attached rescue device for stalled ribosomes...
- Escherichia coli YaeJ protein mediates a novel ribosome-rescue pathway distinct from SsrA- and ArfA-mediated pathwaysYuhei Chadani
Graduate School of Natural Science and Technology, Okayama University, Okayama 700 8530, Japan
Mol Microbiol 80:772-85. 2011..It was also suggested that ArfA and YaeJ rescue the stalled ribosomes by distinct mechanisms...
- Plant cell walls: Protecting the barrier from degradation by microbial enzymesStijn Lagaert
Division of Gene Technology, Department of Biosystems, Katholieke Universiteit Leuven, Kasteelpark Arenberg 21, BE 3001 Leuven, Belgium
Semin Cell Dev Biol 20:1064-73. 2009....
- Metagenome-derived clones encoding two novel lactonase family proteins involved in biofilm inhibition in Pseudomonas aeruginosaC Schipper
Biozentrum Klein Flottbek Mikrobiologie, University of Hamburg, Ohnhorststr 18, D 22609 Hamburg, Germany
Appl Environ Microbiol 75:224-33. 2009..aeruginosa when expressed in P. aeruginosa PAO1. Thus, this is the first study in which metagenome-derived proteins have been expressed in P. aeruginosa to successfully inhibit biofilm formation...
- Thermostable variants of cocaine esterase for long-time protection against cocaine toxicityDaquan Gao
Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536, USA
Mol Pharmacol 75:318-23. 2009..The novel design strategy can be used to develop thermostable mutants of any protein...
- Two Arabidopsis thaliana genes encode functional pectin methylesterase inhibitorsA Raiola
Dipartimento di Biologia Vegetale, Universita di Roma La Sapienza, Piazzale Aldo Moro 5, 00185 Roma, Italy
FEBS Lett 557:199-203. 2004..The occurrence of functional PMEIs in Arabidopsis indicates that a mechanism of controlling pectin esterification by inhibition of endogenous PMEs is present in different plant species...
- Orthologs of a novel archaeal and of the bacterial peptidyl-tRNA hydrolase are nonessential in yeastGuillermina Rosas-Sandoval
Departments of Molecular Biophysics and Biochemistry and Chemistry, Yale University, New Haven, CT 06520 8114, USA
Proc Natl Acad Sci U S A 99:16707-12. 2002..Deletions in Saccharomyces cerevisiae of the pth2 (YBL057c) or pth (YHR189w) orthologs were viable, as was the double deletion strain, implying that the canonical Pth and Pth2 enzymes are not essential for yeast viability...
- Insecticidal Bacillus thuringiensis silences Erwinia carotovora virulence by a new form of microbial antagonism, signal interferenceYi Hu Dong
Institute of Molecular and Cell Biology, National University of Singapore, Singapore 117609
Appl Environ Microbiol 70:954-60. 2004..These results suggest that signal interference mechanisms existing in natural ecosystems could be explored as a new version of antagonism for prevention of bacterial infections...
- Characterization and structural modeling of a new type of thermostable esterase from Thermotoga maritimaMark Levisson
Laboratory of Microbiology, Wageningen University, Hesselink van Suchtelenweg 4, 6703 GT Wageningen, The Netherlands
FEBS J 274:2832-42. 2007..A comparison of the active site pentapeptide motifs revealed that EstD should be grouped into a new family of esterases (Family 10). EstD is the first characterized member of this family...
- Pectin methylesterase inhibitorA Giovane
Department of Biochemistry and Biophysics, 2nd University of Napoli, Via Costantinopoli 16, I 80138, Naples, Italy
Biochim Biophys Acta 1696:245-52. 2004..Affinity chromatography on resin-bound PMEI can also be used to concentrate and detect residual PME activity in fruit and vegetable products...
- Distinction between esterases and lipases: a kinetic study with vinyl esters and TAGHenri Chahinian
Laboratoire de Lipolyse Enzymatique, CNRS, Marseille, France
Lipids 37:653-62. 2002..In this respect, it clearly appears that guinea pig pancreatic lipase and cutinase are unambiguously classified as lipases...
- Characterization of enzymes involved in formation of ethyl esters of long-chain fatty acids in humansM A Diczfalusy
Department of Medical Laboratory Sciences and Technology, Karolinska Institutet, Huddinge University Hospital, SE 141 86 Stockholm, Sweden
J Lipid Res 42:1025-32. 2001..A very low rate of FAEE hydrolysis was detected in heart and adipose tissue, which probably accounts for the previously observed accumulation of FAEE in these organs...
- Structural basis for the substrate recognition and catalysis of peptidyl-tRNA hydrolaseKosuke Ito
Department of Biology, Faculty of Science, Niigata University, 8050 Ikarashi 2 no cho, Nishi ku, Niigata 950 2181, Japan
Nucleic Acids Res 40:10521-31. 2012..Furthermore, we propose an authentic Pth:peptidyl-tRNA complex model and a detailed mechanism for the hydrolysis reaction, based on the present crystal structure and the previous studies' results...
- Radial distribution pattern of pectin methylesterases across the cambial region of hybrid aspen at activity and dormancyF Micheli
Laboratoire d Enzymologie en Milieu Structuré, Département de Biologie Supramoléculaire et Cellulaire, Institut Jacques Monod, 2 place Jussieu, F 75252 Paris Cedex 05, France
Plant Physiol 124:191-9. 2000....
- Deficiency of carboxylesterase 1/esterase-x results in obesity, hepatic steatosis, and hyperlipidemiaAriel D Quiroga
Department of Pediatrics, University of Alberta, Edmonton, Canada
Hepatology 56:2188-98. 2012....
- Role of pectin methylesterases in cellular calcium distribution and blossom-end rot development in tomato fruitSergio T de Freitas
Department of Plant Sciences, University of California, Davis, CA 95616, USA
Plant J 71:824-35. 2012..Our results suggest that apoplastic water-soluble Ca²⁺ concentration influences fruit susceptibility to Ca²⁺ deficiency disorders...
- Complete genome sequence and characterization of the N-acylhomoserine lactone-degrading gene of the potato leaf-associated Solibacillus silvestrisTomohiro Morohoshi
Department of Material and Environmental Chemistry, Graduate School of Engineering, Utsunomiya University, 7 1 2 Yoto, Utsunomiya 321 8585, Japan
J Biosci Bioeng 113:20-5. 2012..carotovorum attenuated maceration of the potato slices. Our results suggest that AHL-degrading activity of ahlS might perform useful functions such as useful biocontrol agents...
- An outer membrane enzyme encoded by Salmonella typhimurium lpxR that removes the 3'-acyloxyacyl moiety of lipid AC Michael Reynolds
Department of Biochemistry, Duke University Medical Center, Durham, North Carolina 27710, USA
J Biol Chem 281:21974-87. 2006..coli O157:H7, Yersinia enterocolitica, Helicobacter pylori, and Vibrio cholerae. The function of LpxR is unknown, but it could play a role in pathogenesis because it might modulate the cytokine response of an infected animal...
- A physiological connection between tmRNA and peptidyl-tRNA hydrolase functions in Escherichia coliNongmaithem Sadananda Singh
Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, 560 012, India
Nucleic Acids Res 32:6028-37. 2004..We discuss the physiological relevance of these observations to highlight a major role of tmRNA in decreasing cellular peptidyl-tRNA load...
- Depot-specific expression of lipolytic genes in human adipose tissues--association among CES1 expression, triglyceride lipase activity and adiposityShuichi Nagashima
Division of Endocrinology and Metabolism, Diabetes Center, Department of Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan
J Atheroscler Thromb 18:190-9. 2011....
- A host lipase detoxifies bacterial lipopolysaccharides in the liver and spleenBaomei Shao
Department of Internal Medicine, University of Texas Southwestern Medical School, Dallas, Texas 75390 9113, USA
J Biol Chem 282:13726-35. 2007..AOAH-mediated deacylation is a previously unappreciated mechanism that prevents prolonged inflammatory reactions to Gram-negative bacteria and LPS in the liver and spleen...
- VANGUARD1 encodes a pectin methylesterase that enhances pollen tube growth in the Arabidopsis style and transmitting tractLixi Jiang
Institute of Molecular and Cell Biology, Singapore 138673
Plant Cell 17:584-96. 2005..Our study suggests that the VGD1 product is required for growth of the pollen tube, possibly via modifying the cell wall and enhancing the interaction of the pollen tube with the female style and transmitting tract tissues...
- The ectopic expression of a pectin methyl esterase inhibitor increases pectin methyl esterification and limits fungal diseases in wheatChiara Volpi
Department of Agrobiology and Agrochemistry, University of Tuscia, Viterbo, Italy
Mol Plant Microbe Interact 24:1012-9. 2011..In addition to their importance for wheat improvement, these results highlight the primary role of pectin despite its low content in the wheat cell wall...
- Role of endoplasmic reticulum neutral lipid hydrolasesAriel D Quiroga
Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada
Trends Endocrinol Metab 22:218-25. 2011..Some of these enzymes might be attractive targets for the treatment of dyslipidemias, viral infection and atherosclerosis...
- Characterization of Thermobifida fusca cutinase-carbohydrate-binding module fusion proteins and their potential application in bioscouringYao Zhang
State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China
Appl Environ Microbiol 76:6870-6. 2010..The improvement in activity and the strong synergistic effect between the fusion proteins and pectinase suggest that they may have better applications in textile bioscouring than the native cutinase...
- Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipaseGuenter Haemmerle
Institute of Molecular Biosciences, University of Graz, Austria
Science 312:734-7. 2006..These results indicate that ATGL is rate limiting in the catabolism of cellular fat depots and plays an important role in energy homeostasis...
- Polymorphisms in the novel gene acyloxyacyl hydroxylase (AOAH) are associated with asthma and associated phenotypesKathleen C Barnes
Division of Allergy and Clinical Immunology, Department of Medicine, The Johns Hopkins University, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
J Allergy Clin Immunol 118:70-7. 2006....
- Methyl esterification of pectin plays a role during plant-pathogen interactions and affects plant resistance to diseasesVincenzo Lionetti
Dipartimento di Biologia e Biotecnologie Charles Darwin, Sapienza Universita di Roma, Piazzale Aldo Moro 5, 00185 Rome, Italy
J Plant Physiol 169:1623-30. 2012..This review focuses on the impact of pectin methyl esterification in plant-pathogen interactions and on the dynamic role of its alteration during pathogenesis...
- Role of the leader sequence in tobacco pectin methylesterase secretionYuri L Dorokhov
Department of Virology, A N Belozersky Institute of Physico Chemical Biology, Moscow State University, Leninsky Gory 1, Laboratory Building A, Moscow 119992, Russia
FEBS Lett 580:3329-34. 2006..The CW targeting was abolished by various deletions in the TM domain, i.e., anchor domain was essential for secretion of GFP to CW. By contrast, even entire deletion of the spacer segment had no influence on GFP targeting...
- Pectin methylesterase, a regulator of pollen tube growthMaurice Bosch
Biology Department, University of Massachusetts, Amherst, Massachusetts 01003, USA
Plant Physiol 138:1334-46. 2005....
- Specificity and enzyme kinetics of the quorum-quenching N-Acyl homoserine lactone lactonase (AHL-lactonase)Lian Hui Wang
Institute of Molecular and Cell Biology, 30 Medical Drive, Singapore 117609
J Biol Chem 279:13645-51. 2004..We conclude that AHL-lactonase is a highly specific enzyme and that the (106)HXDH(109) approximately H(169) of AHL-lactonase represents a novel catalytic motif, which does not rely on zinc or other metal ions for activity...
- Regulation of triglyceride metabolism. IV. Hormonal regulation of lipolysis in adipose tissueKathy Jaworski
Department of Nutritional Sciences and Toxicology, University of California, Berkeley, CA 94720, USA
Am J Physiol Gastrointest Liver Physiol 293:G1-4. 2007..In this review, we summarize and discuss the recent progress made in the regulation of adipocyte lipolysis...
- Quorum quenching: enzymatic disruption of N-acylhomoserine lactone-mediated bacterial communication in Burkholderia thailandensisRicky L Ulrich
Bacteriology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland 21702, USA
Appl Environ Microbiol 70:6173-80. 2004..AiiA lactonases in B. thailandensis reduced AHL accumulation, affected both swarming and twitching motility, increased generation time, altered substrate utilization, and prevented the beta-hemolysis of sheep erythrocytes...
- A novel lipolytic enzyme located in the outer membrane of Pseudomonas aeruginosaS Wilhelm
Lehrstuhl Biologie der Mikroorganismen, Ruhr Universitat, D 44780 Bochum, Germany
J Bacteriol 181:6977-86. 1999..To our knowledge, this esterase is unique in that it exemplifies in P. aeruginosa (i) the first enzyme identified in the outer membrane and (ii) the first example of a type IV secretion mechanism...
- Pectin methylesterase is induced in Arabidopsis upon infection and is necessary for a successful colonization by necrotrophic pathogensAlessandro Raiola
Department of Land, Environment, Agriculture and Forestry, University of Padua, Legnaro PD Italy
Mol Plant Microbe Interact 24:432-40. 2011..We show that, upon infection, Pectobacterium carotovorum and Botrytis cinerea induce in Arabidopsis a rapid expression of AtPME3 that acts as a susceptibility factor and is required for the initial colonization of the host tissue...
- Peptidyl-tRNA hydrolase and its critical role in protein biosynthesisGautam Das
Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore 560012, India
Microbiology 152:2191-5. 2006..This review discusses the aspects of Pth that relate to its history and biochemistry and its physiological connections with various cellular factors...
- Intestinal absorption of dietary cholesteryl ester is decreased but retinyl ester absorption is normal in carboxyl ester lipase knockout miceW Weng
Laboratory of Biochemical Genetics and Metabolism, The Rockefeller University, New York 10021, USA
Biochemistry 38:4143-9. 1999..Overall, the data indicate that in the mouse, other enzymes besides CEL participate in the hydrolysis of dietary cholesteryl esters, retinyl esters, and triglycerides...
- Evolution of supergene families associated with insecticide resistanceHilary Ranson
Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK
Science 298:179-81. 2002..The analyses also provide the means for identifying previously unknown molecules involved in fundamental biological processes such as development...
- A metagenomic analysis of soil bacteria extends the diversity of quorum-quenching lactonasesKashif Riaz
Institut des Sciences du Vegetal, Centre National de la Recherche Scientifique, UPR2355, Gif sur Yvette, France
Environ Microbiol 10:560-70. 2008..coli. Phylogenetic analysis showed that 9 orf out of 20 were related to sequences from members of the Acidobacteria, supporting the hypothesis that the analysed insert might be originated from an organism related to this phylum...
- Spatial control of protein phosphatase 2A (de)methylationSari Longin
Department of Molecular Cell Biology, Faculty of Medicine, KU Leuven, Herestraat 49 bus 901, B 3000 Leuven, Belgium
Exp Cell Res 314:68-81. 2008..PME-1 associates with an inactive PP2A population, regardless of its esterase activity or localization. We propose that stabilization of this inactive, nuclear PP2A pool is a major in vivo function of PME-1...
- Premature leaf senescence modulated by the Arabidopsis PHYTOALEXIN DEFICIENT4 gene is associated with defense against the phloem-feeding green peach aphidVenkatramana Pegadaraju
Division of Biology and the Molecular Cellular and Developmental Biology Program, Kansas State University, Manhattan, Kansas 66506 4901, USA
Plant Physiol 139:1927-34. 2005..Our results suggest that PAD4 modulates the activation of senescence in the aphid-infested leaves, which contributes to basal resistance to GPA...
- Quorum sensing and quorum-quenching enzymesYi Hu Dong
Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos, Singapore 138673
J Microbiol 43:101-9. 2005....
- GDSL lipase-like 1 regulates systemic resistance associated with ethylene signaling in ArabidopsisSun Jae Kwon
School of Life Sciences and Biotechnology, Korea University, Seoul 136 701, Korea
Plant J 58:235-45. 2009..Our results demonstrate that GLIP1-elicited systemic resistance is dependent on ethylene signaling and provide evidence that GLIP1 may mediate the production of a systemic signaling molecule(s)...
- Extremely stable and versatile carboxylesterase from a hyperthermophilic archaeonYuji Hotta
Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Yoshida Honmachi, Sakyo ku, Kyoto 606 8501, Japan
Appl Environ Microbiol 68:3925-31. 2002..The extreme stability against heat and organic solvents, along with its activity towards a tertiary alcohol ester, indicates a high potential for the Est of P. calidifontis in future applications...
- Partial demethylation of oligogalacturonides by pectin methyl esterase 1 is required for eliciting defence responses in wild strawberry (Fragaria vesca)Sonia Osorio
Departamento de Biologia Molecular y Bioquimica, Universidad de Malaga, 29071 Malaga, Spain
Plant J 54:43-55. 2008..Further studies in F. vesca and Nicotiana benthamiana leaves showed that the elicitation capacity of the oligogalacturonides is more specific than previously envisaged...
- Juvenile hormone esterase activity in the pupating and diapausing larvae of Sesamia nonagrioidesChrista Schafellner
Department of Forest Entomology, Forest Pathology, and Forest Protection, University of Natural Resources and Applied Life Sciences, Hasenauerstrasse 38, A 1190 Vienna, Austria
J Insect Physiol 54:916-21. 2008..The data indicate that JHE is not crucial for the switch between larval development, diapause, and metamorphosis in S. nonagrioides...
- Patatins, Kunitz protease inhibitors and other major proteins in tuber of potato cv. KurasGuy Bauw
Department of Biotechnology, Chemistry and Environmental Engineering, Aalborg University, Denmark
FEBS J 273:3569-84. 2006..Furthermore, protein abundance was contrasted with the levels of corresponding gene transcripts found in our previous EST and LongSAGE studies of Kuras tuber...
- Inhibition of Salmonella enterica serovar Typhimurium lipopolysaccharide deacylation by aminoarabinose membrane modificationKiyoshi Kawasaki
Department of Microbiology, University of Washington, Health Sciences Building, K140, Box 357710, 1959 Pacific St N E, Seattle, WA 98195, USA
J Bacteriol 187:2448-57. 2005..Taken together, these results suggest that PagL enzymatic deacylation is posttranslationally inhibited by membrane environments, which either sequester PagL from its substrate or alter its conformation...
- Purification and characterization of an esterase hydrolyzing monoalkyl phthalates from Micrococcus sp. YGJ1Kiyofumi Maruyama
Department of Biomolecular Science, Faculty of Engineering, Gifu University, Gifu 501 1193, Japan
J Biochem 137:27-32. 2005..These findings show that the enzymes bear a close resemblance to the putative phthalate ester hydrolase (PehA) of Arthrobacter keyseri 12B...
- Pectin methylesterase NaPME1 contributes to the emission of methanol during insect herbivory and to the elicitation of defence responses in Nicotiana attenuataEvelyn Körner
Max Planck Institute for Chemical Ecology, Department of Molecular Ecology, Hans Knöll Str 8, D 07745 Jena, Germany
J Exp Bot 60:2631-40. 2009..These latter responses could not be recovered by application of exogenous MeOH. Together, these results indicated that PME contributes, probably indirectly by affecting cell wall properties, to the induction of anti-herbivore responses...
- Senescence marker protein 30 functions as gluconolactonase in L-ascorbic acid biosynthesis, and its knockout mice are prone to scurvyYoshitaka Kondo
Department of Molecular Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo 173 0015, Japan
Proc Natl Acad Sci U S A 103:5723-8. 2006..6% of those in WT control mice. In addition, by using the SMP30 knockout mouse, we demonstrate that the alternative pathway of AA synthesis involving d-glucurono-gamma-lactone operates in vivo, although its flux is fairly small...
- Characterization of two distinct feruloyl esterases, AoFaeB and AoFaeC, from Aspergillus oryzaeTakuya Koseki
Department of Bioresource Engineering, Yamagata University, Tsuruoka, Japan
Appl Microbiol Biotechnol 83:689-96. 2009..Ferulic acid was efficiently released from wheat arabinoxylan when both esterases were applied with xylanase from Thermomyces lanuginosus. Both recombinant proteins also exhibited hydrolytic activity toward chlorogenic acid...
- Purification and partial characterization of a retinyl ester hydrolase from the brush border of rat small intestine mucosa: probable identity with brush border phospholipase BK M Rigtrup
Department of Biochemistry, Vanderbilt University, Nashville, Tennessee 37232 0146
Biochemistry 33:2661-6. 1994..Vmax values were also bile salt dependent. Retinyl palmitate was hydrolyzed most rapidly in the presence of deoxycholate and least rapidly in taurocholate.(ABSTRACT TRUNCATED AT 250 WORDS)..
- Purification and characterization of an extracellular feruloyl esterase from the thermophilic anaerobe Clostridium stercorariumJ A Donaghy
Food Science Division Microbiology, Department of Agriculture for Northern Ireland, Belfast, UK
J Appl Microbiol 88:458-66. 2000..0 and 65 degrees C. At a concentration of 5 mmol l-l, the ions Ca2+, Cu2+, Co2+ and Mn2+ reduced the activity by 70-80%...
- Cloning and expression of the cutinase A gene of Botrytis cinereaC J van der Vlugt-Bergmans
Department of Phytopathology, Wageningen Agricultural University, The Netherlands
Mol Plant Microbe Interact 10:21-9. 1997..The expression of cutA during infection of tomato leaves is low during early phases of infection, but high when the fungus has colonized the leaf and starts to sporulate...
- Overproduction of acyloxyacyl hydrolase by macrophages and dendritic cells prevents prolonged reactions to bacterial lipopolysaccharide in vivoNoredia Ojogun
Department of Internal Medicine, University of Texas Southwestern Medical School, Dallas, TX, USA
J Infect Dis 200:1685-93. 2009..Our results suggest that the extent to which macrophages and dendritic cells produce AOAH may influence the outcome of many gram-negative bacterial diseases...
- Activity-based protein profiling identifies a host enzyme, carboxylesterase 1, which is differentially active during hepatitis C virus replicationDavid R Blais
Steacie Institute for Molecular Sciences, National Research Council Canada, Ottawa, Ontario K1A 0R6, Canada
J Biol Chem 285:25602-12. 2010..In transgenic mice containing human-mouse chimeric livers, HCV infection also correlates with higher levels of endogenous CES1, providing further evidence that CES1 has an important role in HCV propagation...
- Host inactivation of bacterial lipopolysaccharide prevents prolonged tolerance following gram-negative bacterial infectionMingfang Lu
Infectious Disease Division, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390 9113, USA
Cell Host Microbe 4:293-302. 2008..coli challenge. Inactivating LPS, an immunostimulatory microbial molecule, is thus important for restoring effective host defenses following Gram-negative bacterial infection in animals...
- Identification and characterization of bacterial cutinaseSheng Chen
State Key Laboratory of Food Science and Technology, Jiangnan University, 1800 Lihu Ave, Wuxi, Jiangsu 214122, China
J Biol Chem 283:25854-62. 2008..This is the first report of cutinase encoding genes from bacterial sources...
- All-trans-retinyl esters are the substrates for isomerization in the vertebrate visual cycleDeviprasad R Gollapalli
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 45 Shattuck Street, Boston, Massachusetts 02115, USA
Biochemistry 42:5809-18. 2003..The converse is true with vitamin A. These data unambiguously establish all-trans-retinyl esters as the precursors of 11-cis-retinol...
- Phloem-based resistance to green peach aphid is controlled by Arabidopsis PHYTOALEXIN DEFICIENT4 without its signaling partner ENHANCED DISEASE SUSCEPTIBILITY1Venkatramana Pegadaraju
Division of Biology and Molecular Cellular and Developmental Biology Program, Kansas State University, Manhattan, KS 66506, USA
Plant J 52:332-41. 2007..Thus, a PAD4 mode of action that is uncoupled from EDS1 determines the extent of aphid feeding in the phloem...
- Peptidyl-tRNA hydrolase in Bacillus subtilis, encoded by spoVC, is essential to vegetative growth, whereas the homologous enzyme in Saccharomyces cerevisiae is dispensableJeanne Menez
UPR 9073 du CNRS, Institut de Biologie Physico Chimique, Paris, France
Mol Microbiol 45:123-9. 2002....
- Methanol production is enhanced by expression of an Aspergillus niger pectin methylesterase in tobacco cellsTomohisa Hasunuma
Department of Biotechnology, Graduate School of Engineering, Osaka University, 2 1, Yamadaoka, Suita 565 0871, Japan
J Biotechnol 106:45-52. 2003..7% compared to the vector control transformant. This is the first report of methanol overproduction in plant cells by means of genetic engineering...
- Endotoxin-binding proteins modulate the susceptibility of bacterial endotoxin to deacylation by acyloxyacyl hydrolaseTheresa L Gioannini
Inflammation Program, Department of Internal Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
J Biol Chem 282:7877-84. 2007..The susceptibility of the monomeric endotoxin-CD14 complex to AOAH may help constrain endotoxin-induced TLR4 activation when endotoxin and membrane CD14 are present in excess of MD-2/TLR-4...
- Retinal pigment epithelium-retinal G protein receptor-opsin mediates light-dependent translocation of all-trans-retinyl esters for synthesis of visual chromophore in retinal pigment epithelial cellsRoxana A Radu
Jules Stein Eye Institute, California, USA
J Biol Chem 283:19730-8. 2008..This translocation permits insoluble all-trans-retinyl esters to be utilized as substrate for the synthesis of a new visual chromophore...
- Molecular screening for GS2 lipase regulators: inhibition of keratinocyte retinylester hydrolysis by TIP47Jay G Gao
Department of Oral Biology and Pathology, School of Dental Medicine, State University of New York at Stony Brook, USA
J Invest Dermatol 126:2087-95. 2006..Residues within the carboxyl alpha3-alpha4 helices are essential in the context of the full-length protein. Residues within the amino-terminal also contribute depending on the context...
- Autotransporters with GDSL passenger domains: molecular physiology and biotechnological applicationsSusanne Wilhelm
Institute of Molecular Enzyme Technology, Heinrich Heine University Dusseldorf, Research Center Julich, Juelich, Germany
Chembiochem 12:1476-85. 2011..Furthermore, it is capable of displaying different classes of enzymes in a range of Gram-negative bacteria including Escherichia coli, and FACS-based high-throughput screening for enantioselective esterases could be achieved using EstA...
- Use of Pseudomonas putida EstA as an anchoring motif for display of a periplasmic enzyme on the surface of Escherichia coliTaek Ho Yang
Department of Biological Sciences, Korea Advanced Institute of Science and Technology, 373 1, Guseong Dong, Yuseong Gu, Daejeon 305 701, Republic of Korea
Appl Environ Microbiol 70:6968-76. 2004..coli. This investigation also provides a possible topological model of the EstA translocator domain, which might serve as a basis for the construction of fusion proteins containing heterologous passenger domains...
- Occurrence, properties, and applications of feruloyl esterasesTakuya Koseki
Department of Bioresource Engineering, Faculty of Agriculture, Yamagata University, 1 23 Wakaba machi, Tsuruoka 997 8555, Japan
Appl Microbiol Biotechnol 84:803-10. 2009..An overview of the current knowledge of fungal feruloyl esterases focusing on the diverse of substrate specificity and potential applications is presented in this review. Furthermore, biological functions of ferulic acid are discussed...
- Characterization of Esterase A, a Pseudomonas stutzeri A15 AutotransporterToon Nicolay
Centre of Microbial and Plant Genetics, KU Leuven, Heverlee, Belgium
Appl Environ Microbiol 78:2533-42. 2012..No specific phenotype was detected for an estA-negative mutant. Overall, P. stutzeri A15 EstA is a new candidate for the surface display of proteins in environmentally relevant biotechnological applications...
- Polymorphisms in RYBP and AOAH genes are associated with chronic rhinosinusitis in a Chinese population: a replication studyYuan Zhang
Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, People s Republic of China
PLoS ONE 7:e39247. 2012..The development of CRS is believed to be the result of combined interactions between the genetic background of the affected subject and environmental factors...
- SELECTIVE THERAPY OF TUMORS THAT OVEREXPRESS C MYCPHILIP POTTER; Fiscal Year: 2006..These studies will assess the effectiveness of VDEPT with rCE or hiCE and CPT-11 at eliminating tumor cells from appropriate animal models of human disease. ..
- Novel Therapeutic Approaches for Narcotic OverdosePHILIP POTTER; Fiscal Year: 2009..Overall, these studies should allow development of novel therapeutic approaches for the treatment of cocaine overdose. ..
- Analysis of Therapeutic Adipose Tissue RemodelingJAMES GRANNEMAN; Fiscal Year: 2004..2) To examine adipose tissue cellular dynamics during therapeutic remodeling induced by agonist activation of beta3-adrenergic receptors and PPAR-gamma. ..
- Trihalomethane Pharmacokinetics and PharmacodynamicsMATTHEW ROSS; Fiscal Year: 2003..It is also essential to determine if the same metabolic pathways are operative in rodents and humans and if metabolic flux through the different pathways is similar. ..
- Structure and Function of the Human Pregnane X ReceptorMATTHEW REDINBO; Fiscal Year: 2006..5. Elucidate structures of hPXR in complexes with large drugs like rifampicin and taxol. 6. Examine structures of mouse and rabbit PXR to determine why different species respond to distinct xenobiotics. ..
- BETA 1 AND BETA 3 ADRENORECEPTORSJAMES GRANNEMAN; Fiscal Year: 2001..Aim 2. To further characterize the differential signaling properties of beta1- beta3-AR and to examine the cellular and molecular basis. Specific Aim 3. To examine the molecular pharmacology of beta3-AR-selective agonists. ..
- Structure and Mechanism of Human Topoisomerase IMATTHEW REDINBO; Fiscal Year: 2004....
- Evaluation in Primates of Cocaine Esterase for the Treatment of Cocaine ToxicityMei Chuan Ko; Fiscal Year: 2010..Dose-response functions for each enzyme will be obtained repeatedly and blood samples analyzed for titer development so that tolerance to the effects of CocE can be monitored. ..
- Intrathecal Opioid-Induced PruritusMei Chuan Ko; Fiscal Year: 2003..These studies would provide a systematic understanding of the pharmacology of intrathecal morphine-induced pruritus in primates and establish the basis for identifying potential therapeutically effective antipruritics. ..
- Contribution of ATGL in skeletal muscle to lipid metabolism and insulin actionERIN KERSHAW; Fiscal Year: 2008..Evaluating the role of ATGL-mediated fat breakdown in skeletal muscle will provide important insights into the pathophysiology and treatment of obesity, insulin resistance, and related metabolic disorders. [unreadable] [unreadable]..
- LIPID A MODIFICATION SYSTEMS IN GRAM-NEGATIVE BACTERIACHRISTIAN RAETZ; Fiscal Year: 2008..leguminosarum lipid A; and IV) i characterization of enzymes that incorporate the unique inner core sugars of/?, leguminosarum LPS. ..
- AIRWAY DISEASE AND COCKROACH EXPOSURE IN PUBLIC HOUSINGKathleen Barnes; Fiscal Year: 2008..We hope that with the data to be generated, we will positively impact the health of urban US populations who are disproportionally suffering from asthma morbidity and mortality. ..
- Coordinate Regulation Of Nuclear DGK-theta and PLDDANIEL RABEN; Fiscal Year: 2009..We believe that an understanding of nuclear lipid signaling is key to our ability to intervene in events such as wound repair and tissue remodeling. ..
- INTERACTIONS OF ENDOTOXIN WITH PLASMA AND CELLSRobert Munford; Fiscal Year: 2007..abstract_text> ..
- Carboxyl Ester Lipase Affects Hepatic HDL MetabolismPHILIP HOWLES; Fiscal Year: 2009....
- Genome-Wide Association Studies of Asthma in Populations of African DescentKathleen Barnes; Fiscal Year: 2008..Findings from this study will provide a better understanding of the complex pathways related to risk of asthma and associated phenotypes. [unreadable] [unreadable] [unreadable]..
- Neural Progenitor Cells as Cancer Therapy VectorsKaren Aboody; Fiscal Year: 2009..The described approach might then be adapted to the treatment of other solid tumors by careful choice of appropriate therapeutic transgenes. ..
- Light & Heavy Alcohol, Paraoxonase & Oxidized LDL StatusRaj Lakshman; Fiscal Year: 2008..These investigations are likely to lead to new insights in our understanding of the cardioprotective effects of ligh drinking and proatherogenic effects of heavy drinking both at clinical and at molecular levels. ..
- Clinical Features in Nursing Home Residents with Suspected UTIManisha Juthani Mehta; Fiscal Year: 2008..This study will create an evidence-based definition of UTI. Future studies will identify residents with UTI in whom antibiotic therapy improves clinical outcome. [unreadable] [unreadable] [unreadable]..
- The Effect of a Mixture of Pesticides on the Rat Cardiac ProteomeJohn Crow; Fiscal Year: 2007..Our long-term objective is to better understand the extent to which commonly used pesticides and other environmental chemicals influence heart disease and its treatment. [unreadable] [unreadable] [unreadable]..
- MECHANISMS OF ACTIONS OF ALCOHOL AND OMEGA 3-FATTY ACIDSRaj Lakshman; Fiscal Year: 2004....
- Mechanism and Engineering of an Autoinducer HydrolaseWalter Fast; Fiscal Year: 2004..If successful, the incremental truncation technique used to create these hybrids may be applicable for "humanizing" other therapeutically useful bacterial enzymes. ..
- ENDOGENOUSLY REGULATED IMMUNOMODULATIONRobert Munford; Fiscal Year: 2003..abstract_text> ..
- Phospholipases in the Pathogenesis of M. tuberculosisSarah Parker; Fiscal Year: 2006..Dr. Parker is committed to research in M. tuberculosis, and it holds a special significance to her because of her life experiences. ..
- The Acquisition of Bacterial Vaginosis in LesbiansJeanne Marrazzo; Fiscal Year: 2006..Lesbian couples provide a unique opportunity to conduct comparative studies of vaginal microbial ecology in sex partners, and to directly analyze determinants of transmission. ..
- Genetic Studies of Immune Responsiveness to CockroachKathleen Barnes; Fiscal Year: 2007..We will also examine the interactive effect of current cockroach allergen exposure and susceptibility loci associated with asthma severity. ..
- CAROTENOID BINDING PROTEIN AND CAROTENOID METABOLISMRaj Lakshman; Fiscal Year: 2002..2. Molecular biology techniques to measure CCBP mRNA levels in different tissues and to clone its cDNA. 3. HPLC procedures for quantification of various carotenoids and retinoids. ..
- in vivo characterization of D2/D3 agonists & antagonistsGregory Collins; Fiscal Year: 2007..abstract_text> ..
- Role of NPC1L1 in regulating energy metabolism, nutrient utilization & weight gaiPhilip N Howles; Fiscal Year: 2010....
- MEMBRANE IMMUNOGLOBULIN ASSEMBLY AND FUNCTIONShiv Pillai; Fiscal Year: 2002..Since the majority of human lymphomas develop form activated B-cells, these signaling mechanisms are likely to be of direct relevance for a significant proportion of human cancers. ..
- Marginal zone B lymphocytes and blood borne pathogensShiv Pillai; Fiscal Year: 2004..Finally we will attempt to determine whether antigen-specific MZ B cells, as opposed to follicuar B cells, can readily capture and present blood borne antigens, and thus activate na'fve T cells. ..
- Hydrophobics transport across the outer membraneBert van den Berg; Fiscal Year: 2009..These structures will also allow us to determine whether mechanistic differences exist between LCFA and xenobiotics transport. ..
- Role of PP2A in tauopathiesEstelle Sontag; Fiscal Year: 2007..If our model is validated, dietary folate supplementation and PPMT may be novel therapeutic targets for strategies aimed at slowing down the disease process in AD, and possibly other neurodegenerative dementias. [unreadable] [unreadable]..
- The role of PKK in NFkappa B activationShiv Pillai; Fiscal Year: 2007..PKK represents a novel enzyme that may be critical in pathways that are important in cancer, inflammation, cell survival, and differentiation. ..
- Molecular identification of a sialyl 9-O-acetyl transferaseShiv Pillai; Fiscal Year: 2008..The gene that codes for an enzyme that controls the strength of the immune response will be studied. This gene may be an important target for the treatment of lupus and other related diseases. [unreadable] [unreadable] [unreadable]..
- Cell Signaling, PXR Phosphorylation & Drug DispositionJeffrey Staudinger; Fiscal Year: 2009..These studies will provide additional insight into the regulation of drug disposition and drug-drug interaction. ..
- Studies on human peripheral B lymphocytesShiv Pillai; Fiscal Year: 2005....
- Role of PP2A in tauopathiesEstelle Sontag; Fiscal Year: 2006....