steroid 17 alpha hydroxylase

Summary

Summary: A microsomal cytochrome P450 enzyme that catalyzes the 17-alpha-hydroxylation of progesterone or pregnenolone and subsequent cleavage of the residual two carbons at C17 in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP17 gene, generates precursors for glucocorticoid, androgen, and estrogen synthesis. Defects in CYP17 gene cause congenital adrenal hyperplasia (ADRENAL HYPERPLASIA, CONGENITAL) and abnormal sexual differentiation.

Top Publications

  1. ncbi Developmentally regulated expression of adrenal 17 alpha-hydroxylase cytochrome P450 in the mouse embryo
    D S Keeney
    Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Endocrinology 136:4872-9. 1995
  2. ncbi Polymorphisms associated with circulating sex hormone levels in postmenopausal women
    Alison M Dunning
    Cancer Research UK, Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK
    J Natl Cancer Inst 96:936-45. 2004
  3. ncbi Cytochrome P450 17alpha hydroxylase/17,20 lyase (CYP17) function in cholesterol biosynthesis: identification of squalene monooxygenase (epoxidase) activity associated with CYP17 in Leydig cells
    Ying Liu
    Department of Biochemistry and Molecular Biology, Georgetown University Medical Center, 3900 Reservoir Road Northwest, Washington, D C 20057, USA
    Mol Endocrinol 19:1918-31. 2005
  4. ncbi A polymorphism in CYP17 and endometrial cancer risk
    C A Haiman
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Cancer Res 61:3955-60. 2001
  5. ncbi NF-1C, Sp1, and Sp3 are essential for transcription of the human gene for P450c17 (steroid 17alpha-hydroxylase/17,20 lyase) in human adrenal NCI-H295A cells
    C J Lin
    Department of Pediatrics and the Metabolic Research Unit, University of California San Francisco, San Francisco, California 94143 0978, USA
    Mol Endocrinol 15:1277-93. 2001
  6. ncbi Association between the T27C polymorphism in the cytochrome P450 c17alpha (CYP17) gene and risk factors for breast cancer
    Chi Chen Hong
    Division of Epidemiology and Statistics, Ontario Cancer Institute, 610 University Avenue, Toronto, Ontario, M5G 2M9, Canada
    Breast Cancer Res Treat 88:217-30. 2004
  7. ncbi Risk of endometrial cancer and estrogen replacement therapy history by CYP17 genotype
    R McKean-Cowdin
    Department of Preventive Medicine, University of Southern California Keck School of Medicine, Norris Comprehensive Cancer Center, Los Angeles 90033 0800, USA
    Cancer Res 61:848-9. 2001
  8. pmc A polymorphism in the CYP17 gene is associated with male breast cancer
    I E Young
    University of Edinburgh Department of Pathology, Molecular Medicine Centre, UK
    Br J Cancer 81:141-3. 1999
  9. ncbi The genetic and functional basis of isolated 17,20-lyase deficiency
    D H Geller
    Department of Pediatrics, University of California San Francisco 94143 0978, USA
    Nat Genet 17:201-5. 1997
  10. ncbi Cloning and sequence of the human gene for P450c17 (steroid 17 alpha-hydroxylase/17,20 lyase): similarity with the gene for P450c21
    J Picado-Leonard
    Department of Pediatrics, University of California, San Francisco 94143
    DNA 6:439-48. 1987

Detail Information

Publications185 found, 100 shown here

  1. ncbi Developmentally regulated expression of adrenal 17 alpha-hydroxylase cytochrome P450 in the mouse embryo
    D S Keeney
    Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Endocrinology 136:4872-9. 1995
    ....
  2. ncbi Polymorphisms associated with circulating sex hormone levels in postmenopausal women
    Alison M Dunning
    Cancer Research UK, Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK
    J Natl Cancer Inst 96:936-45. 2004
    ..We investigated the association between levels of sex hormones and single nucleotide polymorphisms (SNPs) in genes coding for the enzymes that regulate them...
  3. ncbi Cytochrome P450 17alpha hydroxylase/17,20 lyase (CYP17) function in cholesterol biosynthesis: identification of squalene monooxygenase (epoxidase) activity associated with CYP17 in Leydig cells
    Ying Liu
    Department of Biochemistry and Molecular Biology, Georgetown University Medical Center, 3900 Reservoir Road Northwest, Washington, D C 20057, USA
    Mol Endocrinol 19:1918-31. 2005
    ....
  4. ncbi A polymorphism in CYP17 and endometrial cancer risk
    C A Haiman
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Cancer Res 61:3955-60. 2001
    ..9%; P = 0.05) and estradiol (+8.5%; P = 0.17). These data suggest that the A2 allele of CYP17 decreases endometrial cancer risk, but has only weak effects on endogenous estrogen levels among postmenopausal women...
  5. ncbi NF-1C, Sp1, and Sp3 are essential for transcription of the human gene for P450c17 (steroid 17alpha-hydroxylase/17,20 lyase) in human adrenal NCI-H295A cells
    C J Lin
    Department of Pediatrics and the Metabolic Research Unit, University of California San Francisco, San Francisco, California 94143 0978, USA
    Mol Endocrinol 15:1277-93. 2001
    ..Thus, Sp1 and Sp3 binding to the -227/-184 site and NF-1C proteins binding to the -107/-85 and the -178/-152 sites are crucial for adrenal transcription of the human gene for P450c17...
  6. ncbi Association between the T27C polymorphism in the cytochrome P450 c17alpha (CYP17) gene and risk factors for breast cancer
    Chi Chen Hong
    Division of Epidemiology and Statistics, Ontario Cancer Institute, 610 University Avenue, Toronto, Ontario, M5G 2M9, Canada
    Breast Cancer Res Treat 88:217-30. 2004
    ..Our findings suggest that the CYP17 A2 allele is associated with hormone levels, and interacts with insulin levels and diet to affect breast density levels and potentially breast cancer risk...
  7. ncbi Risk of endometrial cancer and estrogen replacement therapy history by CYP17 genotype
    R McKean-Cowdin
    Department of Preventive Medicine, University of Southern California Keck School of Medicine, Norris Comprehensive Cancer Center, Los Angeles 90033 0800, USA
    Cancer Res 61:848-9. 2001
    ..31; 95% CI, 0.53-3.21). These preliminary findings suggest that CYP17 or other variants in estrogen biosynthesis or metabolism pathways may be potential markers of endometrial cancer susceptibility due to ERT...
  8. pmc A polymorphism in the CYP17 gene is associated with male breast cancer
    I E Young
    University of Edinburgh Department of Pathology, Molecular Medicine Centre, UK
    Br J Cancer 81:141-3. 1999
    ..This case-control study from the South East of Scotland shows that a polymorphism of the CYP17 gene is associated with an increased risk of male breast cancer...
  9. ncbi The genetic and functional basis of isolated 17,20-lyase deficiency
    D H Geller
    Department of Pediatrics, University of California San Francisco 94143 0978, USA
    Nat Genet 17:201-5. 1997
    ..These are the first proven cases of isolated 17,20-lyase deficiency, and they demonstrate a novel mechanism for loss of enzymatic activity...
  10. ncbi Cloning and sequence of the human gene for P450c17 (steroid 17 alpha-hydroxylase/17,20 lyase): similarity with the gene for P450c21
    J Picado-Leonard
    Department of Pediatrics, University of California, San Francisco 94143
    DNA 6:439-48. 1987
    ..The 5'-flanking DNA contains sequences similar to consensus sequences regulated by cAMP and glucocorticoids...
  11. ncbi Building a multigenic model of breast cancer susceptibility: CYP17 and HSD17B1 are two important candidates
    H S Feigelson
    American Cancer Society, National Home Office, Atlanta, Georgia 30329 4251, USA
    Cancer Res 61:785-9. 2001
    ..05; 95% CI, 1.29-7.25). These findings suggest that breast cancer risk has a strong genetic component and supports the theory that the underlying mechanism of "complex traits" can be understood using a multigenic model of candidate genes...
  12. ncbi Overview of dehydroepiandrosterone biosynthesis
    Richard J Auchus
    Division of Endocrinology and Metabolism, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas 75390 8857, USA
    Semin Reprod Med 22:281-8. 2004
    ..These characteristics are illustrated by the fetal adrenal cortex and the zona reticularis, which are dedicated to the synthesis of DHEA and DHEA-sulfate...
  13. ncbi P450c17 deficiency in Brazilian patients: biochemical diagnosis through progesterone levels confirmed by CYP17 genotyping
    Regina M Martin
    Unidade de Endocrinologia do Desenvolvimento, Divisão de Endocrinologia, Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, SP, Brazil
    J Clin Endocrinol Metab 88:5739-46. 2003
    ....
  14. ncbi Novel C-17-heteroaryl steroidal CYP17 inhibitors/antiandrogens: synthesis, in vitro biological activity, pharmacokinetics, and antitumor activity in the LAPC4 human prostate cancer xenograft model
    Venkatesh D Handratta
    Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, Baltimore, 655 West Baltimore Street, Baltimore, Maryland 21201 1559, USA
    J Med Chem 48:2972-84. 2005
    ..In view of these impressive anticancer properties, compound 5 is a strong candidate for development for the treatment of human prostate cancer...
  15. ncbi No association of polymorphisms in CYP17, CYP19, and HSD17-B1 with plasma estradiol concentrations in 1,090 British women
    Ruth C Travis
    Cancer Research UK Epidemiology Unit, University of Oxford, Oxford OX2 6HE, United Kingdom
    Cancer Epidemiol Biomarkers Prev 13:2282-4. 2004
  16. ncbi Association of CYP17, CYP19, CYP1B1, and COMT polymorphisms with serum and urinary sex hormone concentrations in postmenopausal women
    Shelley S Tworoger
    The Fred Hutchinson Cancer Research Center, Cancer Prevention Research Program, Seattle, Washington, USA
    Cancer Epidemiol Biomarkers Prev 13:94-101. 2004
    ..This study provides further evidence that genetic variation may appreciably alter sex hormone concentrations in postmenopausal women not taking hormone therapy...
  17. ncbi HSD17B1 and CYP17 polymorphisms and breast cancer risk among Chinese women in Singapore
    Anna H Wu
    Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA, USA
    Int J Cancer 104:450-7. 2003
    ..41, 95% CI=1.56-3.72; RR=4.39, 95% CI=1.71-11.30, respectively). The latter gene-parity effects were especially pronounced in postmenopausal women...
  18. ncbi Estrogen-metabolizing gene polymorphisms in the assessment of breast carcinoma risk and fibroadenoma risk in Caucasian women
    Lukas A Hefler
    Department of Obstetrics and Gynecology, Medical University Vienna, Vienna, Austria
    Cancer 101:264-9. 2004
    ..In these candidate genes, no critical combination of single-nucleotide polymorphisms (SNPs) for assessing breast carcinoma risk has been reported to date...
  19. ncbi The risk of breast cancer associated with dietary lignans differs by CYP17 genotype in women
    Susan E McCann
    Department of Social and Preventive Medicine, University at Buffalo, NY 14214, USA
    J Nutr 132:3036-41. 2002
    ..12, 95% CI 0.03-0.50). Our results suggest that CYP17 genotype may be important in modifying the effect on breast cancer risk of exogenous estrogens, particularly for premenopausal women...
  20. ncbi Genetic polymorphism in CYP17 and breast cancer risk in Japanese women
    Y Miyoshi
    Department of Surgical Oncology, Osaka University Medical School, Suita Shi, Japan
    Eur J Cancer 36:2375-9. 2000
    ..96, 95% CI: 0.56-1.63). These results suggest that CYP17 polymorphism(1931T/C) would be useful in the selection of Japanese women at a high risk for developing breast cancer at the age of > or = 55 years...
  21. ncbi CYP17 and breast cancer risk: the polymorphism in the 5' flanking area of the gene does not influence binding to Sp-1
    V Nedelcheva Kristensen
    Department of Genetics, Institute of Cancer Research, The Norwegian Radium Hospital, University Clinic, Oslo
    Cancer Res 59:2825-8. 1999
    ..Age at onset, tumor grade, lymph node status and distant metastases, stage, and estrogen and progesterone receptor status were not associated with the CYP17 genotype...
  22. pmc Variants in estrogen-biosynthesis genes CYP17 and CYP19 and breast cancer risk: a family-based genetic association study
    Habibul Ahsan
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA
    Breast Cancer Res 7:R71-81. 2005
    ....
  23. ncbi Steroid metabolism gene CYP17 polymorphism and the development of breast cancer
    K Mitrunen
    Department of Industrial Hygiene and Toxicology, Finnish Institute of Occupational Health, Helsinki
    Cancer Epidemiol Biomarkers Prev 9:1343-8. 2000
    ..Because these findings are based on relatively small numbers in stratified analysis, they should, however, be interpreted with caution before being confirmed in future studies...
  24. pmc CYP17 genetic polymorphism, breast cancer, and breast cancer risk factors
    Christine B Ambrosone
    Department of Epidemiology, Roswell Park Cancer Institute, Buffalo, New York, USA
    Breast Cancer Res 5:R45-51. 2003
    ..We investigated the role of the MspAI genetic polymorphism in the 5' region of CYP17 on risk of breast cancer and as a modifier of reproductive risk factors...
  25. pmc CYP17 5'-UTR MspA1 polymorphism and the risk of premenopausal breast cancer in a German population-based case-control study
    Emaculate Verla-Tebit
    Division of Clinical Epidemiology, German Cancer Research Center, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Breast Cancer Res 7:R455-64. 2005
    ..Higher levels of estrogen have been reported among young nulliparous women with the A2 allele. Therefore we assessed the impact of CYP17 genotypes on the risk of premenopausal breast cancer, with emphasis on parity...
  26. ncbi CYP gene polymorphisms and early menarche
    J Lai
    Centre for Research in Women s Health, University of Toronto, 790 Bay Street, Toronto, Ontario, M5G 1N8, Canada
    Mol Genet Metab 74:449-57. 2001
    ..The polymorphic variants of the CYP3A4, CYP17, CYP1B1, and CYP1A2 genes are unlikely to influence age of menarche...
  27. ncbi Effect of small interfering RNAs of cytochrome P450 17alpha-hydroxylase/17,20-lyase (CYP17) on androgen biosynthesis in theca cells
    Jing Du
    Center for Reproductive Medicine, First Affiliated Hospital of Sun Yat sen University, Zhongshan Er Road, Guangzhou, Guangdong, China
    Cell Biol Int 32:469-72. 2008
    ..RNAi effectively reduced the expression of exogenous CYP17 in HeLa cells by up to 50%. The CYP17 mRNA and androstenedione production of theca cells were slightly, but not significantly, reduced when compared with non-specific siRNA...
  28. ncbi Estrogen-biosynthesis gene CYP17 and its interactions with reproductive, hormonal and lifestyle factors in breast cancer risk: results from the Long Island Breast Cancer Study Project
    Yu Chen
    Department of Environmental Medicine and New York University Cancer Institute, New York University School of Medicine, New York, NY 10016, USA
    Carcinogenesis 29:766-71. 2008
    ..In conclusion, the findings suggest that the CYP17 variant C allele may increase breast cancer risk in conjunction with long-term HRT use and high BMI in postmenopausal women...
  29. ncbi CYP17 and SULT1A1 gene polymorphisms in Indian breast cancer
    Priya Chacko
    Division of Molecular Medicine, Drug Development and Chemoinformatics, Regional Cancer Centre, Thiruvananthapuram 695011, Kerala State, India
    Breast Cancer 11:380-8. 2004
    ..Single nucleotide polymorphisms of these genes may result in inter-individual variability in steroid hormone biosynthesis and metabolism thus influence the development of breast cancer...
  30. ncbi The CYP17 MspA1 polymorphism and breast cancer risk: a meta-analysis
    Zheng Ye
    Bioinformatics Group, Centre for Molecular Genetics and Toxicology, School of Biological Sciences, University of Wales Swansea, Singleton Park, Swansea SA2 8PP, UK
    Mutagenesis 17:119-26. 2002
    ..The OR for age at menarche (> or = 13) was 0.87 (95% CI 0.62-1.17). Our results suggest that CYP17 MspA1 polymorphism may be at best a weak modifier of breast cancer risk but is not a significant independent risk factor...
  31. ncbi CYP17 gene polymorphism and its association with high-risk north Indian breast cancer patients
    Anurupa Chakraborty
    Institute of Pathology, Safdarjang Hospital Campus, New Delhi, India
    J Hum Genet 52:159-65. 2007
    ..160). The present findings suggest that CYP17 A2 allele gene polymorphism might play a significant role in breast cancer development in young Indian women...
  32. ncbi CYP17 gene polymorphisms: prevalence and associations with hormone levels and related factors. a HuGE review
    L Sharp
    Epidemiology Group, Department of Medicine and Therapeutics, University of Aberdeen, Aberdeen, United Kingdom
    Am J Epidemiol 160:729-40. 2004
    ..Further investigation of relations between genotype and hormone levels, exogenous hormone use, and markers of hormonal status may advance understanding of hormonally mediated diseases...
  33. ncbi Estrogen-metabolizing gene polymorphisms, but not estrogen receptor-alpha gene polymorphisms, are associated with the onset of menarche in healthy postmenopausal Japanese women
    Itsuo Gorai
    Department of Obstetrics and Gynecology, Yokohama City University School of Medicine, Yokohama 236 0004, Japan
    J Clin Endocrinol Metab 88:799-803. 2003
    ..A1/A1H/Hwt/wt genotypes, on ages at menarche and/or natural menopause. The results suggest that the estrogen-metabolizing CYP17 genotype influences age at menarche in healthy postmenopausal Japanese women...
  34. ncbi Overexpression of theca-cell messenger RNA in polycystic ovary syndrome does not correlate with polymorphisms in the cholesterol side-chain cleavage and 17alpha-hydroxylase/C(17-20) lyase promoters
    Saíd Daneshmand
    Department of Obstetrics and Gynecology, Cedars Sinai Medical Center Burns and Allen Research Institute, UCLA School of Medicine, 8700 Beverly Boulevard, Davis 2066, Los Angeles, CA 90048 0750, USA
    Fertil Steril 77:274-80. 2002
    ..To determine whether overexpression of CYP17 or CYP11A messenger (m)RNA in theca cells from polycystic ovaries is related to polymorphic regions in the gene promoters that may increase transcription...
  35. ncbi Wnt-4 deficiency alters mouse adrenal cortex function, reducing aldosterone production
    Minna Heikkilä
    Biocenter Oulu and Department of Biochemistry, Faculties of Science and Medicine, University of Oulu, FIN 90014 University of Oulu, Finland
    Endocrinology 143:4358-65. 2002
    ..In summary, these results point to a role for Wnt-4 in adrenal gland development and function...
  36. ncbi Inhibins differentially antagonize activin and bone morphogenetic protein action in a mouse adrenocortical cell line
    Paul G Farnworth
    Prince Henry s Institute, P O Box 5152, Clayton, Victoria 3168, Australia
    Endocrinology 147:3462-71. 2006
    ..In conclusion, inhibins A and B differentially antagonize the actions of activins and BMPs to control adrenocortical C(19) steroid production...
  37. ncbi Significantly increased cortisol secretion in normal adrenocortical cells transfected with K-ras mutants derived from human functional adrenocortical tumors
    C H Hsu
    Department of Clinical Pathology, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC
    DNA Cell Biol 20:231-8. 2001
    ..The K-ras oncogene significantly increases cortisol secretion by normal adrenocortical cells...
  38. ncbi No association of the 5' promoter region polymorphism of CYP17 with breast cancer risk in Japan
    N Hamajima
    Division of Epidemiology and Prevention, Aichi Cancer Center, Chikusa ku, Nagoya 464 8681, Japan
    Jpn J Cancer Res 91:880-5. 2000
    ....
  39. ncbi Tissue-specific, cyclic adenosine 3',5'-monophosphate-induced, and phorbol ester-repressed transcription from the human P450c17 promoter in mouse cells
    S T Brentano
    Department of Pediatrics, University of California, San Francisco 94143 0978
    Mol Endocrinol 4:1972-9. 1990
    ..Both basal and cAMP-induced expression were much lower in MA-10 cells than in Y1 cells and increased with increasing promoter length to -774.(ABSTRACT TRUNCATED AT 250 WORDS)..
  40. ncbi CYP17 genotype and breast cancer risk
    A Weston
    National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    Cancer Epidemiol Biomarkers Prev 7:941-4. 1998
    ..Allelic frequencies between different ethnic groups were not found to be different with the exception of Hispanic controls, in which the genotypic distribution was not consistent with the Hardy-Weinberg equilibrium...
  41. ncbi Concerning the CYP17 MspA1 polymorphism and breast cancer risk: a meta-analysis
    Heather Spencer Feigelson
    Mutagenesis 17:445-6; author reply 447-8. 2002
  42. pmc CYP17 promoter polymorphism and breast cancer risk in males and females in relation to BRCA2 status
    K Gudmundsdottir
    Molecular and Cell Biology Research Laboratory, Icelandic Cancer Society, 125 Reykjavik, Iceland
    Br J Cancer 88:933-6. 2003
    ..Our findings do not indicate a role for the CYP17 T-C polymorphism in female breast cancer, but a role in male carriers of a BRCA2 mutation could not be excluded because of the small sample size...
  43. pmc CYP17 genetic polymorphism, breast cancer, and breast cancer risk factors: Australian Breast Cancer Family Study
    Jiun Horng Chang
    Centre for Genetic Epidemiology, The University of Melbourne, Victoria, Australia
    Breast Cancer Res 7:R513-21. 2005
    ..We attempted to replicate the findings of studies assessing such interactions with the -34T-->C polymorphism...
  44. ncbi [Association of polymorphism of genetic markers of CYP19 and CYP17 with sporadic breast cancer]
    V V Artamonov
    Medical Genetic Research Center, Russian Academy of Medical Sciences, Moscow, 115478 Russia
    Mol Biol (Mosk) 37:975-82. 2003
    ..5% vs. 20.2%, P = 0.04). Risk of BC was especially high in the presence of both factors (7.3% vs. 0%, P < 0.01). Allele (TTTA)8 and genotype A2/A2 were assumed to be risk factors of BC...
  45. ncbi CYP17 promoter polymorphism and breast cancer in Australian women under age forty years
    A B Spurdle
    Cancer Unit, Joint Experimental Oncology Programme, The Queensland Institute of Medical Research, and The University of Queensland, Brisbane, Australia
    J Natl Cancer Inst 92:1674-81. 2000
    ..Because steroid hormone exposure is known to influence breast cancer risk, we conducted a population-based, case-control-family study to assess the relationship between the CYP17 promoter polymorphism and early-onset breast cancer...
  46. pmc No association between a polymorphism in the steroid metabolism gene CYP17 and risk of breast cancer
    A M Dunning
    CRC Human Cancer Genetics Research Group, Addenbrooke s Hospital, Cambridge, UK
    Br J Cancer 77:2045-7. 1998
    ..37] or advanced breast cancer (OR 0.88, CI 0.38-2.01) in C allele carriers, nor any association between age at menarche and genotype. We conclude that these alleles do not significantly alter breast cancer risk in the English population...
  47. pmc CYP17 gene polymorphism in relation to breast cancer risk: a case-control study
    Kristjana Einarsdóttir
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Breast Cancer Res 7:R890-6. 2005
    ..The c.1-34T>C 5' promoter region polymorphism in cytochrome P450c17 (CYP17), a key enzyme in the biosynthesis of estrogen, has been associated with breast cancer risk, but most previous studies have been relatively small...
  48. ncbi Association of CYP17 genetic polymorphism with intra-tumoral estradiol concentrations but not with CYP17 messenger RNA levels in breast cancer tissue
    Yasuo Miyoshi
    Department of Surgical Oncology, Osaka University Graduate School of Medicine, 2 2 Yamada oka, Suita, Osaka 565 0871, Japan
    Cancer Lett 195:81-6. 2003
    ....
  49. ncbi Role of adiponectin in regulating ovarian theca and granulosa cell function
    Dana V Lagaly
    Department of Animal Science, Oklahoma State University, Stillwater, OK 74078, United States
    Mol Cell Endocrinol 284:38-45. 2008
    ..These results indicate that the inhibitory effects of adiponectin on steroidogenesis are primarily localized to theca cells and that the response of theca cells to adiponectin (i.e., ADIPOR2) may be regulated by LH and IGF-I...
  50. ncbi An investigation of the effects of methylmercury in rats fed different dietary fats and proteins: testicular steroidogenic enzymes and serum testosterone levels
    Mark J McVey
    Toxicology Research Division, Health Products and Foods Branch, Food Directorate, Health Canada, Sir Fredrick G Banting Research Centre, 2202D1 Tunney s Pasture, Ottawa, ON, Canada K1A 0L2
    Food Chem Toxicol 46:270-9. 2008
    ..In conclusion, these studies show that different lipid diets can alter the toxic effects of MeHg on male rat steroidogenesis in terms of serum testosterone and steroidogenic enzyme activities...
  51. ncbi Cattle and sheep use different promoters to direct the expression of the aromatase cytochrome P450 encoding gene, Cyp19, during pregnancy
    Jens Vanselow
    Research Institute for the Biology of Farm Animals, Research Unit Molecular Biology, Wilhelm Stahl Allee 2, 18196 Dummerstorf, Germany
    Domest Anim Endocrinol 27:99-114. 2004
    ..1 derived transcripts. Contrary to the bovine, the sheep corpus luteum also showed considerable P1.5 derived expression. This demonstrates that cattle and sheep use different promoters to direct Cyp19 expression during pregnancy...
  52. ncbi Inhibitory effect of tributyltin on expression of steroidogenic enzymes in mouse testis
    Suel Kee Kim
    Division of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, Republic of Korea
    Int J Toxicol 27:175-82. 2008
    ..These adverse effects of TBT would cause serious defects in testicular development and function...
  53. ncbi Steroidogenic enzyme expression within the adrenal cortex during early human gestation
    M Goto
    Division of Human Genetics, Southampton University, Southampton, UK
    Endocr Res 28:641-5. 2002
    ..These data raise the possibility of de novo cortisol biosynthesis during the first trimester of human development and are relevant to the pathophysiology of 46,XX virilization in CYP21 deficiency...
  54. ncbi Molecular epidemiology of prostate cancer: androgens and polymorphisms in androgen-related genes
    Christos Ntais
    Division of Endocrinology, Department of Internal Medicine, University of Ioannina School of Medicine, Ioannina 45110, Greece
    Eur J Endocrinol 149:469-77. 2003
    ....
  55. ncbi Immunohistochemical localization of steroidogenic enzymes in corpus luteum of wild sika deer during early mating season
    Yukiko Matsuura
    Laboratory of Wildlife Biology, Department of Environmental Veterinary Science, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    Jpn J Vet Res 51:167-72. 2004
    ..The existence of two functional corpora lutea from the early mating season through pregnancy suggests that progesterone secreted by two or more corpora lutea is necessary for maintenance of pregnancy in sika deer...
  56. ncbi Cultured bovine trophoblast cells differentially express genes encoding key steroid synthesis enzymes
    J Vanselow
    Forschungsinstitut für die Biologie landwirtschaftlicher Nutztiere, Wilhelm Stahl Allee 2, D 18196 Dummerstorf, Germany
    Placenta 29:531-8. 2008
    ..The cells represent an in vitro model to study the regulation of key genes of placental progesterone and androgen but not of oestrogen biosynthesis...
  57. ncbi Steroidogenic gene expression during sex determination in the frog Rana rugosa
    Koichi Maruo
    Department of Biology, Faculty of Education and Integrated Arts and Sciences, Waseda University, 1 6 1 Nishi Waseda, Shinjuku ku, Tokyo 169 8050, Japan
    Gen Comp Endocrinol 158:87-94. 2008
    ..Taken together, the results suggest that CYP17 has a major influence on testis development and that CYP19 plays a similar role in ovary development. However, the factors that up-regulate their expression remain to be identified...
  58. pmc Polymorphisms in steroid hormone biosynthesis genes and risk of breast cancer and fibrocystic breast conditions in Chinese women
    Lori C Sakoda
    Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 17:1066-73. 2008
    ..Our findings support the possibility that common allelic variation at the CYP11A1 D15S520 locus alters breast cancer risk in Chinese women...
  59. ncbi PSA and androgen-related gene (AR, CYP17, and CYP19) polymorphisms and the risk of adenocarcinoma at prostate biopsy
    Rodrigo Mattos dos Santos
    Institute of Biosciences, Sao Paulo State University, UNESP, Botucatu, Sao Paulo, Brazil
    DNA Cell Biol 27:497-503. 2008
    ..Taken together, these findings suggest that the PSA genotype should be a clinically relevant biomarker to predict the PCa risk...
  60. ncbi In vitro modulation of steroidogenesis and gene expression by melatonin: a study with porcine antral follicles
    V S Tanavde
    Department of Molecular Endocrinology, National Institute for Research in Reproductive Health, ICMR, Mumbai, India
    Endocr Res 29:399-410. 2003
    ..Our results indicate that melatonin modulates ovarian theca cell steroidogenesis at the molecular level and this modulation may be mediated by its effects on the transcriptional activity of the steroidogenic enzymes...
  61. ncbi Polymorphisms in the P450 c17 (17-hydroxylase/17,20-Lyase) and P450 c19 (aromatase) genes: association with serum sex steroid concentrations and bone mineral density in postmenopausal women
    John Somner
    Department of Chemical Pathology, St Thomas Hospital, London, SE1 7EH United Kingdom
    J Clin Endocrinol Metab 89:344-51. 2004
    ..012). Subjects with the CC genotype had significantly lower BMD (mean +/- SD: TT, 0.7 +/- 0.16; CC, 0.6 +/- 0.08 g/cm(2); P = 0.006). In conclusion, both CYP 17 and CYP 19 are candidate genes for osteoporosis in postmenopausal women...
  62. ncbi [Genetic determinants of anatomical variants of the prostate]
    H Hamadeh
    CeRePP EA3104, Universite Paris VII, Paris, France
    Prog Urol 18:214-22. 2008
    ..The authors evaluated the correlation between specific gene polymorphisms involved in androgen and oestrogen synthesis and gross (prostatic weight) and microscopic anatomy (stroma/epithelium ratio) of the prostate during ageing...
  63. ncbi The identification of two CYP17 alleles in the South African Angora goat
    Karl Heinz Storbeck
    Department of Biochemistry, University of Stellenbosch, Slenbosch, South Africa
    Drug Metab Rev 39:467-80. 2007
    ..Our data implicates CYP17 as the primary cause of the observed hypoadrenocorticoidism in the South African Angora goat...
  64. ncbi Hormonally active nontransformed human ovarian cell culture from oophorectomy specimens: methods of development and initial characterization
    Donna Seto-Young
    Division of Endocrinology, Department of Medicine, Beth Israel Medical Center and Albert Einstein College of Medicine, NY 10003, USA
    Horm Res 64:238-47. 2005
    ....
  65. ncbi Identifying susceptibility genes for prostate cancer--a family-based association study of polymorphisms in CYP17, CYP19, CYP11A1, and LH-beta
    Julie A Douglas
    Department of Human Genetics, University of Michigan, Room 5912, Buhl Building, Ann Arbor, MI 48109 0618, USA
    Cancer Epidemiol Biomarkers Prev 14:2035-9. 2005
    ....
  66. ncbi A hepatocarcinogenic tryptophan-pyrolyzate component, Trp-P-1, decreases serum total testosterone level and induces hepatic Cyp1a2 in male mice
    Masakuni Degawa
    Department of Molecular Toxicology and the COE Program in the 21st Century, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Cancer Sci 97:32-7. 2006
    ....
  67. ncbi Patterns of expression of steroidogenic enzymes during the first wave of the ovine estrous cycle as compared to the preovulatory follicle
    R Duggavathi
    Department of Veterinary Biomedical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK, Canada
    Anim Reprod Sci 91:345-52. 2006
    ....
  68. ncbi Ovarian features of the wild collared peccary (Tayassu tajacu) from the northeastern Peruvian Amazon
    Pedro Mayor
    Department of Animal Health and Anatomy, Faculty of Veterinary, Autonomous University of Barcelona, Bellaterra, E 08193 Barcelona, Spain
    Gen Comp Endocrinol 147:268-75. 2006
    ..This suggests that the corpora lutea seems to remain steroidogenically active throughout pregnancy and likely contribute to progesterone production during pregnancy...
  69. ncbi Triphenyltin and Tributyltin inhibit pig testicular 17beta-hydroxysteroid dehydrogenase activity and suppress testicular testosterone biosynthesis
    Shuji Ohno
    Department of Biochemistry, Hoshi University College of Pharmacy and Pharmaceutical Sciences, 2 4 41 Ebara, Shinagawa ku, Tokyo 142 8501, Japan
    Steroids 70:645-51. 2005
    ..Based on these results, it appears possible that the effects of TBT and TPT are largely due to direct inhibition of 17beta-HSD activity in vivo...
  70. ncbi Use of organ culture to study the human fetal testis development: effect of retinoic acid
    Romain Lambrot
    Institut National de la Santé et de la Recherche Médicale U 566, Commissariat a l Energie Atomique, Universite Paris 7, Route du Panorama BP 6, 92265 Fontenay aux Roses Cedex, France
    J Clin Endocrinol Metab 91:2696-703. 2006
    ..In human, the chronology of the testicular development has been extensively studied, but the factors implicated in the onset and the regulation of gametogenesis and steroidogenesis remain hardly known...
  71. ncbi Immunolocalization of steroidogenic enzymes P450scc, 3betaHSD, P450c17, and P450arom in Göttingen miniature pig testes
    Qiang Weng
    Faculty of Biological Science and Technology, Beijing Forestry University, China
    J Reprod Dev 51:299-304. 2005
    ..These results suggested that adult GM pig testes have the ability to produce germ cells throughout the year, and the synthesis of progestin, androgen and estrogen occurs in the Leydig cells of GM pig testes...
  72. ncbi Endogenous estrogens inhibit mouse fetal Leydig cell development via estrogen receptor alpha
    Geraldine Delbes
    Unité de Gamétogenèse et Génotoxicité, Institut National de la Sante et de la Recherche Medicale Unite 566, Commissariat a l Energie Atomique, Universite Paris 7, Denis Diderot, Fontenay aux Roses, France
    Endocrinology 146:2454-61. 2005
    ..Thus, this study shows that endogenous estrogens physiologically inhibit steroidogenesis via ER alpha by acting directly on the testis early in fetal and neonatal development...
  73. ncbi Changes in mRNAs encoding steroidogenic acute regulatory protein, steroidogenic enzymes and receptors for gonadotropins during spermatogenesis in rainbow trout testes
    M Kusakabe
    School of Aquatic and Fishery Sciences, University of Washington, 1140 Boat Street NE, Seattle, Washington 98195 5020, USA
    J Endocrinol 189:541-54. 2006
    ....
  74. ncbi Variants in estrogen biosynthesis genes, sex steroid hormone levels, and endometrial cancer: a HuGE review
    Sara H Olson
    Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Am J Epidemiol 165:235-45. 2007
    ..Larger studies or combined studies that allow for investigation of gene-gene and gene-environment interactions are warranted...
  75. ncbi Effects of dietary fats and proteins on rat testicular steroidogenic enzymes and serum testosterone levels
    Mark J McVey
    Toxicology Research Division, Health Products and Foods Branch, Food Directorate, Health Canada, Sir Fredrick G Banting Research Centre, 2202D1 Tunney s Pasture, Ottawa, ON, Canada K1A 0L2
    Food Chem Toxicol 46:259-69. 2008
    ....
  76. ncbi Elevated expression of P450c17 (CYP17) during testicular formation in the frog
    Ryosuke Iwade
    Department of Biology, Faculty of Education and Integrated Arts and Sciences, Waseda University, 1 6 1 Nishi Waseda, Shinjuku ku, Tokyo 169 8050, Japan
    Gen Comp Endocrinol 155:79-87. 2008
    ..Taken together, the results suggest that CYP17 is very involved in testicular differentiation of the gonad in R. rugosa...
  77. ncbi Presence of sex steroids and cytochrome P450 genes in amphioxus
    Takanobu Mizuta
    Center for Advanced Marine Research, Ocean Research Institute, University of Tokyo, Nakano, Tokyo 164 8639, Japan
    Endocrinology 148:3554-65. 2007
    ..This study is the first evidence to suggest the presence of CYP enzymes in sex steroid production in invertebrates...
  78. ncbi Testicular toxicity of profenofos in matured male rats
    Gihan Gamal Moustafa
    Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, N18, W9, Kita ku, Sapporo, 060 0818, Japan
    Arch Toxicol 81:875-81. 2007
    ..Furthermore, we propose that the above three steroidogenic-related genes and the gene of acrosomal reaction as potential biomarkers of testicular toxicity...
  79. ncbi Developmental expression of key steroidogenic enzymes in the brain of protandrous black porgy fish, Acanthopagrus schlegeli
    S Tomy
    Department of Aquaculture, National Taiwan Ocean University, Keelung, Taiwan
    J Neuroendocrinol 19:643-55. 2007
    ..The study suggests an important role for brain aromatase in male black porgy brain sex differentiation, and considers the possibility of a role for this enzyme in neurogenesis...
  80. ncbi Serum sex steroid hormone levels and polymorphisms of CYP17 and SRD5A2: implication for prostate cancer risk
    H Kakinuma
    Department of Urology, Akita University School of Medicine, 1 1 1 Hondo, Akita 010 8543, Japan
    Prostate Cancer Prostatic Dis 7:333-7. 2004
    ..The linear trends across the CYP17 genotypes in serum-free testosterone and androstenedione levels were found, suggesting the importance of the polymorphism of CYP17 in determining the circulating androgen levels...
  81. ncbi Disorders of androgen synthesis--from cholesterol to dehydroepiandrosterone
    Walter L Miller
    Department of Pediatrics, University of California, San Francisco, California 94142 0978, USA
    Med Princ Pract 14:58-68. 2005
    ..Mutations of POR are a new, recently described disorder manifesting as the Antley-Bixler skeletal dysplasia syndrome, and a form of polycystic ovary syndrome...
  82. ncbi Spermatogenesis, serum testosterone levels and immunolocalization of steroidogenic enzymes in the wild male Japanese black bear (Ursus thibetanus japonicus)
    Tsukasa Okano
    United Graduate School of Veterinary Medicine, Gifu University
    J Vet Med Sci 65:1093-9. 2003
    ..Leydig cells, Sertoli cells and germ cells have the capability of synthesizing androgen, and Leydig cells, Sertoli cells, spermatids and spermatogonia have the capability of synthesizing estrogen in Japanese black bears...
  83. ncbi Purification of cytochromes P-450(scc) and P-450(17 alpha) by steroid-binding affinity column chromatography
    M Kuwada
    Department of Biochemistry, School of Medicine, Kitasato University, 1-15-1 Kitasato, Sagamihara, Kanagawa 228-0829, Japan
    J Biochem Biophys Methods 49:417-31. 2001
    ..Cytochromes P-450(scc) and P-450(17 alpha) were determined to have isoelectric points of 8.0 and 6.5 in isoelectric focusing on a pH gradient gel. Cytochrome P-450s can be purified between 425- and 1000-fold from the crude extracts...
  84. ncbi Prostate carcinoma risk and allelic variants of genes involved in androgen biosynthesis and metabolism pathways
    A G Latil
    Center for Research into Prostate Pathologies, Evry, France
    Cancer 92:1130-7. 2001
    ..The authors evaluated the association between polymorphisms in genes involved in the androgen biosynthesis and metabolism pathway and the risk of prostate carcinoma...
  85. ncbi Liver receptor homologue-1 is expressed in human steroidogenic tissues and activates transcription of genes encoding steroidogenic enzymes
    R Sirianni
    Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    J Endocrinol 174:R13-7. 2002
    ..Of the promoters examined only HSD3B2 was more sensitive to LRH than SF1. The high level of ovarian and testicular LRH expression make it likely that LRH plays an important role in the regulation of gonadal function...
  86. ncbi Immunoelectron microscopic localization of three key steroidogenic enzymes (cytochrome P450(scc), 3 beta-hydroxysteroid dehydrogenase and cytochrome P450(c17)) in rat adrenal cortex and gonads
    G Pelletier
    Oncology and Molecular Endocrinology Research Center, Laval University Medical Center CHUL, and Laval University, Quebec, Canada G1V 4G2
    J Endocrinol 171:373-83. 2001
    ....
  87. ncbi Normal onset, but prolonged expression, of Sry gene in the B6.YDOM sex-reversed mouse gonad
    C H Lee
    Urology Research Laboratory, Royal Victoria Hospital, Montreal, Canada
    Dev Biol 165:442-52. 1994
    ..YDOM gonad appears to be impaired downstream of Sry transcription, resulting in persistent Sry transcripts and a delay in onset of other genes involved in testicular differentiation...
  88. ncbi Regulation of microsomal P450, redox partner proteins, and steroidogenesis in the developing testes of the neonatal pig
    F M Moran
    Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, California 95616 8743, USA
    Endocrinology 143:3361-9. 2002
    ..Neither P450c17 nor P450arom can account for the decline in total microsomal P450. Reductase and cytochrome b(5) expression appears to be constitutive, but reductase levels saturate both P450c17 and P450arom...
  89. ncbi Influence of cytokines and growth factors on distinct steroidogenic enzymes in vitro: a short tabular data collection
    M Herrmann
    Institute of Sports and Preventive Medicine, University of Saarland, 66041 Saarbrucken, Germany
    Ann N Y Acad Sci 966:166-86. 2002
    ..This collection summarizes the current information on how the mentioned cytokines and growth factors influence particular enzyme steps...
  90. pmc Estrogen receptor-alpha mediates an intraovarian negative feedback loop on thecal cell steroidogenesis via modulation of Cyp17a1 (cytochrome P450, steroid 17alpha-hydroxylase/17,20 lyase) expression
    Fuminori Taniguchi
    Department of Obstetrics and Gynecology, Tottori University Hospital, Yonago, Japan
    FASEB J 21:586-95. 2007
    ..Hence, these findings provide novel evidence of an intraovarian ER alpha function that may be critical to the latter stages of folliculogenesis and overall ovarian function...
  91. ncbi Adrenocorticotrophic hormone (ACTH) stimulation of sheep fetal adrenal cortex can occur without increased expression of ACTH receptor (ACTH-R) mRNA
    A M Carter
    Department of Physiology and Pharmacology, University of Southern Denmark, Odense
    Reprod Fertil Dev 14:1-6. 2002
    ..It was concluded that ACTH is able to increase plasma cortisol concentrations in the sheep fetus by up-regulating cortisol synthesis in the adrenal gland, but that in vivo this does not require up-regulation of ACTH-R mRNA...
  92. ncbi CYP17 genetic polymorphism in endometrial cancer: are only steroids involved?
    Lev M Berstein
    Laboratory of Oncoendocrinology, Prof N N Petrov Research Institute of Oncology, Pesochny 2, St Petersburg, Russia
    Cancer Lett 180:47-53. 2002
    ..A1/A1 CYP17 variant may be associated with untraditional (non-steroidal) pathways that calls for corresponding preventive measures in high-risk groups...
  93. ncbi 17beta-estradiol treatment decreases steroidogenic enzyme messenger ribonucleic acid levels in the rainbow trout testis
    M Govoroun
    Institut National de la Recherche Agronomique, Laboratoire Institut National de la Recherche Agronomique-Station Commune de Recherches en Ichtyophysiologie, , Campus de Beaulieu, 35042 Rennes Cedex, France
    Endocrinology 142:1841-8. 2001
    ..The decrease in P45011beta mRNA, and thus inhibition of the synthesis of testicular 11-oxygenated androgens, may be an important step required for the active feminization of these genetic males...
  94. ncbi Metformin directly inhibits androgen production in human thecal cells
    G R Attia
    Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75235-9032, USA
    Fertil Steril 76:517-24. 2001
    ..CONCLUSION(S): Our results suggest that metformin may have a direct effect on thecal cells' androgen production...
  95. ncbi Developmental changes in localization of steroid synthesis enzymes in camelid placenta
    F B P Wooding
    Physiology Department, Cambridge University, Downing Street, Cambridge CB2 3EG, UK
    Reproduction 126:239-47. 2003
    ....
  96. ncbi Human skin is a steroidogenic tissue: steroidogenic enzymes and cofactors are expressed in epidermis, normal sebocytes, and an immortalized sebocyte cell line (SEB-1)
    Diane Thiboutot
    Department of Dermatology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Invest Dermatol 120:905-14. 2003
    ..These data demonstrate that the skin is in fact a steroidogenic tissue. The clinical significance of this finding in mediating androgenic skin disorders such as acne, hirsutism, or androgenetic alopecia remains to be established...
  97. ncbi Loss of oocytes in Dazl knockout mice results in maintained ovarian steroidogenic function but altered gonadotropin secretion in adult animals
    J R McNeilly
    Medical Research Council Human Reproductive Sciences Unit, University of Edinburgh Center for Reproductive Biology, Scotland
    Endocrinology 141:4284-94. 2000
    ..Furthermore, in the +/- mice, the enhanced plasma inhibin B implies a role for Dazl protein within the oocyte either from more small follicles or increased inhibin B production from each follicle...
  98. ncbi Autoantibodies to steroidogenic enzymes in patients with premature ovarian failure with and without Addison's disease
    C Dal Pra
    Chair of Clinical Immunology and Allergy, Division of Endocrinology, Department of Medical and Surgical Sciences, University of Padua, Via Ospedale 105, Padua, Italy
    Eur J Endocrinol 148:565-70. 2003
    ....
  99. ncbi RU-486 inhibits rat gonadal steroidogenesis
    P E Sanchez
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, Bethesda, Maryland
    Horm Metab Res 21:369-71. 1989
    ..Ovarian 17-hydroxylase but not 3 beta-hydroxysteroid dehydrogenase activity was decreased in the animals receiving the drug. We conclude that RU-486 inhibits both testicular and ovarian steroidogenesis in the rat...
  100. ncbi Steroidogenic enzyme expression in the rat cochlea
    Eric Lecain
    LNRS, UMR 7060, Faculté Lariboisière, Hopital Lariboisiere, Paris, France
    Acta Otolaryngol 123:187-91. 2003
    ..We thus hypothesized that local production of steroids in the inner ear may regulate cochlear fluid exchanges...
  101. ncbi Normal prenatal but arrested postnatal sexual development of luteinizing hormone receptor knockout (LuRKO) mice
    F P Zhang
    Department of Physiology, Institute of Biomedicine, University of Turku FIN 20520, Turku, Finland
    Mol Endocrinol 15:172-83. 2001
    ....

Research Grants34

  1. A STUDY OF TROPIC HORMONE ACTION IN CARCINOMA CELLS
    J Mason; Fiscal Year: 1990
    ..These findings will provide insight into the interdependent actions and mechanisms of endocrine paracrine, and autocrine factors to alter differentiated cell function...
  2. Fusion Proteins As Probes of P450 Structure and Function
    Richard Auchus; Fiscal Year: 2004
    ..In addition, this approach might be generally applicable to structural studies of membrane-bound proteins. ..
  3. ESTROGEN, DIET, GENETICS AND ENDOMETRIAL CANCER
    Sara Olson; Fiscal Year: 2005
    ..This study will provide data on genetic susceptibility in endometrial cancer in conjunction with established risk factors, as well as the first epidemiologic data on the more lethal serous and clear cell tumors. ..
  4. A Genome-Wide Association Study of Non-Hodgkin Lymphoma
    Christine F Skibola; Fiscal Year: 2010
    ..The data generated from this study will provide a framework for further investigation within the NHL consortium, InterLymph. Results will later be combined with that from other InterLymph case-control studies in pooled analyses. ..
  5. New Paradigms of P450-mediated Steroids Metabolism
    Alan Conley; Fiscal Year: 2006
    ..abstract_text> ..
  6. MENOPAUSAL TRANSITION: A BIOBEHAVIORAL MODEL OF SYMPTOMS
    Ellen Mitchell; Fiscal Year: 2006
    ..abstract_text> ..
  7. ANDROGEN PRODUCTION IN ADRENARCHE AND PCOS
    WALTER MILLER; Fiscal Year: 2006
    ..abstract_text> ..
  8. A Comprehensive Analysis of Genetic Variation in DNA Repair Genes in Relation to
    Christopher Haiman; Fiscal Year: 2007
    ..The ability to accurately identify high-risk sub-groups may have profound implications on endometrial cancer prevention as well as advance research aimed at targeted drug development. [unreadable] [unreadable] [unreadable]..
  9. Lung cancer molecular markers by sex: intergroup study
    Christine Ambrosone; Fiscal Year: 2008
    ..Results from this study, the largest to date to evaluate biomarkers of susceptibility and effect, will likely elucidate reasons for the rise in lung cancer, particularly adenocarcinomas, in smoking and non-smoking women. ..
  10. DIETARY AND GENETIC DETERMINANTS OF MAMMOGRAPHIC DENSITY
    Anna Wu; Fiscal Year: 2008
    ..abstract_text> ..
  11. GENETIC EPIDEMIOLOGY OF PROSTATE CANCER
    Janet Stanford; Fiscal Year: 2008
    ..abstract_text> ..
  12. A genomic scan of hereditary prostate cancer families with an occurrence of colon
    Janet Stanford; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  13. The Role of Hormone Polymorphisms in Menstrual Function and Fertility
    CHANLEY SMALL; Fiscal Year: 2008
    ..The proposed pilot study is an efficient use of existing data and biological specimens to explore these relationships among a subset of important genes in reproductive function. [unreadable] [unreadable] [unreadable]..
  14. Inflammatory Pathway Gene Polymorphisms and Risk of Prostate Cancer
    Janet Stanford; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  15. Fine-mapping of 8q24 and Loci Identified in Genome-Wide Studies for Breast & Colo
    CHRISTOPHER ALAN HAIMAN; Fiscal Year: 2010
    ..We expect findings from this work to guide the development of future preventive, early detection and prognostic strategies ..
  16. 17 alpha-Hydroxylase Expression in Human Ovarian Cells
    Jan M McAllister; Fiscal Year: 2010
    ..Results of these studies will provide both new insights regarding the cause and molecular basis for increased ovarian androgen production, and lead to the development of new targets for treatment of women with PCOS. ..
  17. REDUCTASE INTERACTIONS GOVERNING AROMATASE ACTIVITIES
    Alan Conley; Fiscal Year: 2001
    ..abstract_text> ..
  18. GENETIC STUDIES OF MINERALOCORTICOID FUNCTION
    David Geller; Fiscal Year: 2004
    ....
  19. Oncogenic Human Papillomaviruses & Prostate Cancer Risk
    Janet Stanford; Fiscal Year: 2002
    ..If there is an association, the results will have important public health implications since both the exposure and the disease are common. ..
  20. Pharmacogenetics: Breast Cancer Treatment and Prognosis
    Christine Ambrosone; Fiscal Year: 2005
    ..Individualized dosing according to genotype could contribute to increased efficacy and decreased toxicity among patients being treated for cancer. ..
  21. Naturopathic Treatments: Effects on Estrogen Metabolism
    Heather Greenlee; Fiscal Year: 2003
    ..Data will be collected and analyzed on changes in estrogen rations and hormone profiles. ..
  22. Glucocorticoid Effects on Blood Pressure Regulation
    David Geller; Fiscal Year: 2004
    ....
  23. GENETIC POLYMORPHISMS IN THE GSTPI LOCUS AND PROSTATE CA
    Janet Stanford; Fiscal Year: 2001
    ....
  24. PREGNANCY CHANGES IN UTERINE ARTERY SIGNALING PATHWAYS
    Ian Bird; Fiscal Year: 2004
    ..abstract_text> ..
  25. Antioxidant supplements, genetics, and chemotherapy outcomes
    Christine Ambrosone; Fiscal Year: 2009
    ....
  26. REGULATION OF MIS TYPE II RECEPTOR AND TARGET GENES
    Jose Teixeira; Fiscal Year: 2002
    ....
  27. MECHANISMS OF PREGNANCY INDUCED AT 1 RECEPTOR EXPRESSION
    Ian Bird; Fiscal Year: 2001
    ..Aim 3 is to determine in vitro whether changes in expression result from changes in phospholipase C and PGI2 production. ..
  28. GENETIC POLYMORPHISMS AND PROSTATE CANCER RISK
    Janet Stanford; Fiscal Year: 2001
    ..abstract_text> ..
  29. NSAIDS and Other Medications in Prostate Cancer Etiology
    Janet Stanford; Fiscal Year: 2005
    ..Results of the study may provide unique insights on the pathogenesis of this complex disease and lead to innovative strategies for prostate cancer prevention. ..
  30. Race & Risk Factors for Early/Aggressive Breast Cancer
    Christine Ambrosone; Fiscal Year: 2008
    ..Results from this study will provide much-needed answers as to why African-American women are more likely than Caucasians to be diagnosed with more aggressive disease at an earlier age. ..
  31. Neurosteroids and Smith-Lemli-Optiz Syndrome
    Cedric Shackleton; Fiscal Year: 2005
    ..All studies will require high sensitivity steroid analysis by chemical ionization (CI) GC/MS and HPLC/MS. ..
  32. AUSTRALASIAN COLORECTAL CANCER FAMILY REGISTRY
    John Hopper; Fiscal Year: 2007
    ..i ..
  33. SMITH-LEMLI-OPITZ SYNDROME STEROIDOGENESIS
    Cedric Shackleton; Fiscal Year: 2002
    ..Finally, if ring B dehydrosteroids are produced, is the ratio of the individual dehydrometabolites to corresponding conventional metabolites related to the dehydrocholesterol to cholesterol ratio and clinical severity? ..
  34. Gas chromatograph-mass spectrometer with EI and CI
    Cedric Shackleton; Fiscal Year: 2003
    ..g., malondialdehyde) and markers of DNA damage (incorporation of uracil). Dr Kuypers has several projects on the red cell membrane, which require profiling of fatty acids using EI GC/MS. ..