Genomes and Genes
steroid 17 alpha hydroxylase
Summary: A microsomal cytochrome P450 enzyme that catalyzes the 17-alpha-hydroxylation of progesterone or pregnenolone and subsequent cleavage of the residual two carbons at C17 in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP17 gene, generates precursors for glucocorticoid, androgen, and estrogen synthesis. Defects in CYP17 gene cause congenital adrenal hyperplasia (ADRENAL HYPERPLASIA, CONGENITAL) and abnormal sexual differentiation.
Publications185 found, 100 shown here
- Developmentally regulated expression of adrenal 17 alpha-hydroxylase cytochrome P450 in the mouse embryoD S Keeney
Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
Endocrinology 136:4872-9. 1995....
- Polymorphisms associated with circulating sex hormone levels in postmenopausal womenAlison M Dunning
Cancer Research UK, Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK
J Natl Cancer Inst 96:936-45. 2004..We investigated the association between levels of sex hormones and single nucleotide polymorphisms (SNPs) in genes coding for the enzymes that regulate them...
- Cytochrome P450 17alpha hydroxylase/17,20 lyase (CYP17) function in cholesterol biosynthesis: identification of squalene monooxygenase (epoxidase) activity associated with CYP17 in Leydig cellsYing Liu
Department of Biochemistry and Molecular Biology, Georgetown University Medical Center, 3900 Reservoir Road Northwest, Washington, D C 20057, USA
Mol Endocrinol 19:1918-31. 2005....
- A polymorphism in CYP17 and endometrial cancer riskC A Haiman
Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
Cancer Res 61:3955-60. 2001..9%; P = 0.05) and estradiol (+8.5%; P = 0.17). These data suggest that the A2 allele of CYP17 decreases endometrial cancer risk, but has only weak effects on endogenous estrogen levels among postmenopausal women...
- NF-1C, Sp1, and Sp3 are essential for transcription of the human gene for P450c17 (steroid 17alpha-hydroxylase/17,20 lyase) in human adrenal NCI-H295A cellsC J Lin
Department of Pediatrics and the Metabolic Research Unit, University of California San Francisco, San Francisco, California 94143 0978, USA
Mol Endocrinol 15:1277-93. 2001..Thus, Sp1 and Sp3 binding to the -227/-184 site and NF-1C proteins binding to the -107/-85 and the -178/-152 sites are crucial for adrenal transcription of the human gene for P450c17...
- Association between the T27C polymorphism in the cytochrome P450 c17alpha (CYP17) gene and risk factors for breast cancerChi Chen Hong
Division of Epidemiology and Statistics, Ontario Cancer Institute, 610 University Avenue, Toronto, Ontario, M5G 2M9, Canada
Breast Cancer Res Treat 88:217-30. 2004..Our findings suggest that the CYP17 A2 allele is associated with hormone levels, and interacts with insulin levels and diet to affect breast density levels and potentially breast cancer risk...
- Risk of endometrial cancer and estrogen replacement therapy history by CYP17 genotypeR McKean-Cowdin
Department of Preventive Medicine, University of Southern California Keck School of Medicine, Norris Comprehensive Cancer Center, Los Angeles 90033 0800, USA
Cancer Res 61:848-9. 2001..31; 95% CI, 0.53-3.21). These preliminary findings suggest that CYP17 or other variants in estrogen biosynthesis or metabolism pathways may be potential markers of endometrial cancer susceptibility due to ERT...
- A polymorphism in the CYP17 gene is associated with male breast cancerI E Young
University of Edinburgh Department of Pathology, Molecular Medicine Centre, UK
Br J Cancer 81:141-3. 1999..This case-control study from the South East of Scotland shows that a polymorphism of the CYP17 gene is associated with an increased risk of male breast cancer...
- The genetic and functional basis of isolated 17,20-lyase deficiencyD H Geller
Department of Pediatrics, University of California San Francisco 94143 0978, USA
Nat Genet 17:201-5. 1997..These are the first proven cases of isolated 17,20-lyase deficiency, and they demonstrate a novel mechanism for loss of enzymatic activity...
- Cloning and sequence of the human gene for P450c17 (steroid 17 alpha-hydroxylase/17,20 lyase): similarity with the gene for P450c21J Picado-Leonard
Department of Pediatrics, University of California, San Francisco 94143
DNA 6:439-48. 1987..The 5'-flanking DNA contains sequences similar to consensus sequences regulated by cAMP and glucocorticoids...
- Building a multigenic model of breast cancer susceptibility: CYP17 and HSD17B1 are two important candidatesH S Feigelson
American Cancer Society, National Home Office, Atlanta, Georgia 30329 4251, USA
Cancer Res 61:785-9. 2001..05; 95% CI, 1.29-7.25). These findings suggest that breast cancer risk has a strong genetic component and supports the theory that the underlying mechanism of "complex traits" can be understood using a multigenic model of candidate genes...
- Overview of dehydroepiandrosterone biosynthesisRichard J Auchus
Division of Endocrinology and Metabolism, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas 75390 8857, USA
Semin Reprod Med 22:281-8. 2004..These characteristics are illustrated by the fetal adrenal cortex and the zona reticularis, which are dedicated to the synthesis of DHEA and DHEA-sulfate...
- P450c17 deficiency in Brazilian patients: biochemical diagnosis through progesterone levels confirmed by CYP17 genotypingRegina M Martin
Unidade de Endocrinologia do Desenvolvimento, Divisão de Endocrinologia, Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, SP, Brazil
J Clin Endocrinol Metab 88:5739-46. 2003....
- Novel C-17-heteroaryl steroidal CYP17 inhibitors/antiandrogens: synthesis, in vitro biological activity, pharmacokinetics, and antitumor activity in the LAPC4 human prostate cancer xenograft modelVenkatesh D Handratta
Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, Baltimore, 655 West Baltimore Street, Baltimore, Maryland 21201 1559, USA
J Med Chem 48:2972-84. 2005..In view of these impressive anticancer properties, compound 5 is a strong candidate for development for the treatment of human prostate cancer...
- No association of polymorphisms in CYP17, CYP19, and HSD17-B1 with plasma estradiol concentrations in 1,090 British womenRuth C Travis
Cancer Research UK Epidemiology Unit, University of Oxford, Oxford OX2 6HE, United Kingdom
Cancer Epidemiol Biomarkers Prev 13:2282-4. 2004
- Association of CYP17, CYP19, CYP1B1, and COMT polymorphisms with serum and urinary sex hormone concentrations in postmenopausal womenShelley S Tworoger
The Fred Hutchinson Cancer Research Center, Cancer Prevention Research Program, Seattle, Washington, USA
Cancer Epidemiol Biomarkers Prev 13:94-101. 2004..This study provides further evidence that genetic variation may appreciably alter sex hormone concentrations in postmenopausal women not taking hormone therapy...
- HSD17B1 and CYP17 polymorphisms and breast cancer risk among Chinese women in SingaporeAnna H Wu
Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA, USA
Int J Cancer 104:450-7. 2003..41, 95% CI=1.56-3.72; RR=4.39, 95% CI=1.71-11.30, respectively). The latter gene-parity effects were especially pronounced in postmenopausal women...
- Estrogen-metabolizing gene polymorphisms in the assessment of breast carcinoma risk and fibroadenoma risk in Caucasian womenLukas A Hefler
Department of Obstetrics and Gynecology, Medical University Vienna, Vienna, Austria
Cancer 101:264-9. 2004..In these candidate genes, no critical combination of single-nucleotide polymorphisms (SNPs) for assessing breast carcinoma risk has been reported to date...
- The risk of breast cancer associated with dietary lignans differs by CYP17 genotype in womenSusan E McCann
Department of Social and Preventive Medicine, University at Buffalo, NY 14214, USA
J Nutr 132:3036-41. 2002..12, 95% CI 0.03-0.50). Our results suggest that CYP17 genotype may be important in modifying the effect on breast cancer risk of exogenous estrogens, particularly for premenopausal women...
- Genetic polymorphism in CYP17 and breast cancer risk in Japanese womenY Miyoshi
Department of Surgical Oncology, Osaka University Medical School, Suita Shi, Japan
Eur J Cancer 36:2375-9. 2000..96, 95% CI: 0.56-1.63). These results suggest that CYP17 polymorphism(1931T/C) would be useful in the selection of Japanese women at a high risk for developing breast cancer at the age of > or = 55 years...
- CYP17 and breast cancer risk: the polymorphism in the 5' flanking area of the gene does not influence binding to Sp-1V Nedelcheva Kristensen
Department of Genetics, Institute of Cancer Research, The Norwegian Radium Hospital, University Clinic, Oslo
Cancer Res 59:2825-8. 1999..Age at onset, tumor grade, lymph node status and distant metastases, stage, and estrogen and progesterone receptor status were not associated with the CYP17 genotype...
- Variants in estrogen-biosynthesis genes CYP17 and CYP19 and breast cancer risk: a family-based genetic association studyHabibul Ahsan
Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA
Breast Cancer Res 7:R71-81. 2005....
- Steroid metabolism gene CYP17 polymorphism and the development of breast cancerK Mitrunen
Department of Industrial Hygiene and Toxicology, Finnish Institute of Occupational Health, Helsinki
Cancer Epidemiol Biomarkers Prev 9:1343-8. 2000..Because these findings are based on relatively small numbers in stratified analysis, they should, however, be interpreted with caution before being confirmed in future studies...
- CYP17 genetic polymorphism, breast cancer, and breast cancer risk factorsChristine B Ambrosone
Department of Epidemiology, Roswell Park Cancer Institute, Buffalo, New York, USA
Breast Cancer Res 5:R45-51. 2003..We investigated the role of the MspAI genetic polymorphism in the 5' region of CYP17 on risk of breast cancer and as a modifier of reproductive risk factors...
- CYP17 5'-UTR MspA1 polymorphism and the risk of premenopausal breast cancer in a German population-based case-control studyEmaculate Verla-Tebit
Division of Clinical Epidemiology, German Cancer Research Center, Deutsches Krebsforschungszentrum, Heidelberg, Germany
Breast Cancer Res 7:R455-64. 2005..Higher levels of estrogen have been reported among young nulliparous women with the A2 allele. Therefore we assessed the impact of CYP17 genotypes on the risk of premenopausal breast cancer, with emphasis on parity...
- CYP gene polymorphisms and early menarcheJ Lai
Centre for Research in Women s Health, University of Toronto, 790 Bay Street, Toronto, Ontario, M5G 1N8, Canada
Mol Genet Metab 74:449-57. 2001..The polymorphic variants of the CYP3A4, CYP17, CYP1B1, and CYP1A2 genes are unlikely to influence age of menarche...
- Effect of small interfering RNAs of cytochrome P450 17alpha-hydroxylase/17,20-lyase (CYP17) on androgen biosynthesis in theca cellsJing Du
Center for Reproductive Medicine, First Affiliated Hospital of Sun Yat sen University, Zhongshan Er Road, Guangzhou, Guangdong, China
Cell Biol Int 32:469-72. 2008..RNAi effectively reduced the expression of exogenous CYP17 in HeLa cells by up to 50%. The CYP17 mRNA and androstenedione production of theca cells were slightly, but not significantly, reduced when compared with non-specific siRNA...
- Estrogen-biosynthesis gene CYP17 and its interactions with reproductive, hormonal and lifestyle factors in breast cancer risk: results from the Long Island Breast Cancer Study ProjectYu Chen
Department of Environmental Medicine and New York University Cancer Institute, New York University School of Medicine, New York, NY 10016, USA
Carcinogenesis 29:766-71. 2008..In conclusion, the findings suggest that the CYP17 variant C allele may increase breast cancer risk in conjunction with long-term HRT use and high BMI in postmenopausal women...
- CYP17 and SULT1A1 gene polymorphisms in Indian breast cancerPriya Chacko
Division of Molecular Medicine, Drug Development and Chemoinformatics, Regional Cancer Centre, Thiruvananthapuram 695011, Kerala State, India
Breast Cancer 11:380-8. 2004..Single nucleotide polymorphisms of these genes may result in inter-individual variability in steroid hormone biosynthesis and metabolism thus influence the development of breast cancer...
- The CYP17 MspA1 polymorphism and breast cancer risk: a meta-analysisZheng Ye
Bioinformatics Group, Centre for Molecular Genetics and Toxicology, School of Biological Sciences, University of Wales Swansea, Singleton Park, Swansea SA2 8PP, UK
Mutagenesis 17:119-26. 2002..The OR for age at menarche (> or = 13) was 0.87 (95% CI 0.62-1.17). Our results suggest that CYP17 MspA1 polymorphism may be at best a weak modifier of breast cancer risk but is not a significant independent risk factor...
- CYP17 gene polymorphism and its association with high-risk north Indian breast cancer patientsAnurupa Chakraborty
Institute of Pathology, Safdarjang Hospital Campus, New Delhi, India
J Hum Genet 52:159-65. 2007..160). The present findings suggest that CYP17 A2 allele gene polymorphism might play a significant role in breast cancer development in young Indian women...
- CYP17 gene polymorphisms: prevalence and associations with hormone levels and related factors. a HuGE reviewL Sharp
Epidemiology Group, Department of Medicine and Therapeutics, University of Aberdeen, Aberdeen, United Kingdom
Am J Epidemiol 160:729-40. 2004..Further investigation of relations between genotype and hormone levels, exogenous hormone use, and markers of hormonal status may advance understanding of hormonally mediated diseases...
- Estrogen-metabolizing gene polymorphisms, but not estrogen receptor-alpha gene polymorphisms, are associated with the onset of menarche in healthy postmenopausal Japanese womenItsuo Gorai
Department of Obstetrics and Gynecology, Yokohama City University School of Medicine, Yokohama 236 0004, Japan
J Clin Endocrinol Metab 88:799-803. 2003..A1/A1H/Hwt/wt genotypes, on ages at menarche and/or natural menopause. The results suggest that the estrogen-metabolizing CYP17 genotype influences age at menarche in healthy postmenopausal Japanese women...
- Overexpression of theca-cell messenger RNA in polycystic ovary syndrome does not correlate with polymorphisms in the cholesterol side-chain cleavage and 17alpha-hydroxylase/C(17-20) lyase promotersSaíd Daneshmand
Department of Obstetrics and Gynecology, Cedars Sinai Medical Center Burns and Allen Research Institute, UCLA School of Medicine, 8700 Beverly Boulevard, Davis 2066, Los Angeles, CA 90048 0750, USA
Fertil Steril 77:274-80. 2002..To determine whether overexpression of CYP17 or CYP11A messenger (m)RNA in theca cells from polycystic ovaries is related to polymorphic regions in the gene promoters that may increase transcription...
- Wnt-4 deficiency alters mouse adrenal cortex function, reducing aldosterone productionMinna Heikkilä
Biocenter Oulu and Department of Biochemistry, Faculties of Science and Medicine, University of Oulu, FIN 90014 University of Oulu, Finland
Endocrinology 143:4358-65. 2002..In summary, these results point to a role for Wnt-4 in adrenal gland development and function...
- Inhibins differentially antagonize activin and bone morphogenetic protein action in a mouse adrenocortical cell linePaul G Farnworth
Prince Henry s Institute, P O Box 5152, Clayton, Victoria 3168, Australia
Endocrinology 147:3462-71. 2006..In conclusion, inhibins A and B differentially antagonize the actions of activins and BMPs to control adrenocortical C(19) steroid production...
- Significantly increased cortisol secretion in normal adrenocortical cells transfected with K-ras mutants derived from human functional adrenocortical tumorsC H Hsu
Department of Clinical Pathology, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC
DNA Cell Biol 20:231-8. 2001..The K-ras oncogene significantly increases cortisol secretion by normal adrenocortical cells...
- No association of the 5' promoter region polymorphism of CYP17 with breast cancer risk in JapanN Hamajima
Division of Epidemiology and Prevention, Aichi Cancer Center, Chikusa ku, Nagoya 464 8681, Japan
Jpn J Cancer Res 91:880-5. 2000....
- Tissue-specific, cyclic adenosine 3',5'-monophosphate-induced, and phorbol ester-repressed transcription from the human P450c17 promoter in mouse cellsS T Brentano
Department of Pediatrics, University of California, San Francisco 94143 0978
Mol Endocrinol 4:1972-9. 1990..Both basal and cAMP-induced expression were much lower in MA-10 cells than in Y1 cells and increased with increasing promoter length to -774.(ABSTRACT TRUNCATED AT 250 WORDS)..
- CYP17 genotype and breast cancer riskA Weston
National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
Cancer Epidemiol Biomarkers Prev 7:941-4. 1998..Allelic frequencies between different ethnic groups were not found to be different with the exception of Hispanic controls, in which the genotypic distribution was not consistent with the Hardy-Weinberg equilibrium...
- Concerning the CYP17 MspA1 polymorphism and breast cancer risk: a meta-analysisHeather Spencer Feigelson
Mutagenesis 17:445-6; author reply 447-8. 2002
- CYP17 promoter polymorphism and breast cancer risk in males and females in relation to BRCA2 statusK Gudmundsdottir
Molecular and Cell Biology Research Laboratory, Icelandic Cancer Society, 125 Reykjavik, Iceland
Br J Cancer 88:933-6. 2003..Our findings do not indicate a role for the CYP17 T-C polymorphism in female breast cancer, but a role in male carriers of a BRCA2 mutation could not be excluded because of the small sample size...
- CYP17 genetic polymorphism, breast cancer, and breast cancer risk factors: Australian Breast Cancer Family StudyJiun Horng Chang
Centre for Genetic Epidemiology, The University of Melbourne, Victoria, Australia
Breast Cancer Res 7:R513-21. 2005..We attempted to replicate the findings of studies assessing such interactions with the -34T-->C polymorphism...
- [Association of polymorphism of genetic markers of CYP19 and CYP17 with sporadic breast cancer]V V Artamonov
Medical Genetic Research Center, Russian Academy of Medical Sciences, Moscow, 115478 Russia
Mol Biol (Mosk) 37:975-82. 2003..5% vs. 20.2%, P = 0.04). Risk of BC was especially high in the presence of both factors (7.3% vs. 0%, P < 0.01). Allele (TTTA)8 and genotype A2/A2 were assumed to be risk factors of BC...
- CYP17 promoter polymorphism and breast cancer in Australian women under age forty yearsA B Spurdle
Cancer Unit, Joint Experimental Oncology Programme, The Queensland Institute of Medical Research, and The University of Queensland, Brisbane, Australia
J Natl Cancer Inst 92:1674-81. 2000..Because steroid hormone exposure is known to influence breast cancer risk, we conducted a population-based, case-control-family study to assess the relationship between the CYP17 promoter polymorphism and early-onset breast cancer...
- No association between a polymorphism in the steroid metabolism gene CYP17 and risk of breast cancerA M Dunning
CRC Human Cancer Genetics Research Group, Addenbrooke s Hospital, Cambridge, UK
Br J Cancer 77:2045-7. 1998..37] or advanced breast cancer (OR 0.88, CI 0.38-2.01) in C allele carriers, nor any association between age at menarche and genotype. We conclude that these alleles do not significantly alter breast cancer risk in the English population...
- CYP17 gene polymorphism in relation to breast cancer risk: a case-control studyKristjana Einarsdóttir
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
Breast Cancer Res 7:R890-6. 2005..The c.1-34T>C 5' promoter region polymorphism in cytochrome P450c17 (CYP17), a key enzyme in the biosynthesis of estrogen, has been associated with breast cancer risk, but most previous studies have been relatively small...
- Association of CYP17 genetic polymorphism with intra-tumoral estradiol concentrations but not with CYP17 messenger RNA levels in breast cancer tissueYasuo Miyoshi
Department of Surgical Oncology, Osaka University Graduate School of Medicine, 2 2 Yamada oka, Suita, Osaka 565 0871, Japan
Cancer Lett 195:81-6. 2003....
- Role of adiponectin in regulating ovarian theca and granulosa cell functionDana V Lagaly
Department of Animal Science, Oklahoma State University, Stillwater, OK 74078, United States
Mol Cell Endocrinol 284:38-45. 2008..These results indicate that the inhibitory effects of adiponectin on steroidogenesis are primarily localized to theca cells and that the response of theca cells to adiponectin (i.e., ADIPOR2) may be regulated by LH and IGF-I...
- An investigation of the effects of methylmercury in rats fed different dietary fats and proteins: testicular steroidogenic enzymes and serum testosterone levelsMark J McVey
Toxicology Research Division, Health Products and Foods Branch, Food Directorate, Health Canada, Sir Fredrick G Banting Research Centre, 2202D1 Tunney s Pasture, Ottawa, ON, Canada K1A 0L2
Food Chem Toxicol 46:270-9. 2008..In conclusion, these studies show that different lipid diets can alter the toxic effects of MeHg on male rat steroidogenesis in terms of serum testosterone and steroidogenic enzyme activities...
- Cattle and sheep use different promoters to direct the expression of the aromatase cytochrome P450 encoding gene, Cyp19, during pregnancyJens Vanselow
Research Institute for the Biology of Farm Animals, Research Unit Molecular Biology, Wilhelm Stahl Allee 2, 18196 Dummerstorf, Germany
Domest Anim Endocrinol 27:99-114. 2004..1 derived transcripts. Contrary to the bovine, the sheep corpus luteum also showed considerable P1.5 derived expression. This demonstrates that cattle and sheep use different promoters to direct Cyp19 expression during pregnancy...
- Inhibitory effect of tributyltin on expression of steroidogenic enzymes in mouse testisSuel Kee Kim
Division of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, Republic of Korea
Int J Toxicol 27:175-82. 2008..These adverse effects of TBT would cause serious defects in testicular development and function...
- Steroidogenic enzyme expression within the adrenal cortex during early human gestationM Goto
Division of Human Genetics, Southampton University, Southampton, UK
Endocr Res 28:641-5. 2002..These data raise the possibility of de novo cortisol biosynthesis during the first trimester of human development and are relevant to the pathophysiology of 46,XX virilization in CYP21 deficiency...
- Molecular epidemiology of prostate cancer: androgens and polymorphisms in androgen-related genesChristos Ntais
Division of Endocrinology, Department of Internal Medicine, University of Ioannina School of Medicine, Ioannina 45110, Greece
Eur J Endocrinol 149:469-77. 2003....
- Immunohistochemical localization of steroidogenic enzymes in corpus luteum of wild sika deer during early mating seasonYukiko Matsuura
Laboratory of Wildlife Biology, Department of Environmental Veterinary Science, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
Jpn J Vet Res 51:167-72. 2004..The existence of two functional corpora lutea from the early mating season through pregnancy suggests that progesterone secreted by two or more corpora lutea is necessary for maintenance of pregnancy in sika deer...
- Cultured bovine trophoblast cells differentially express genes encoding key steroid synthesis enzymesJ Vanselow
Forschungsinstitut für die Biologie landwirtschaftlicher Nutztiere, Wilhelm Stahl Allee 2, D 18196 Dummerstorf, Germany
Placenta 29:531-8. 2008..The cells represent an in vitro model to study the regulation of key genes of placental progesterone and androgen but not of oestrogen biosynthesis...
- Steroidogenic gene expression during sex determination in the frog Rana rugosaKoichi Maruo
Department of Biology, Faculty of Education and Integrated Arts and Sciences, Waseda University, 1 6 1 Nishi Waseda, Shinjuku ku, Tokyo 169 8050, Japan
Gen Comp Endocrinol 158:87-94. 2008..Taken together, the results suggest that CYP17 has a major influence on testis development and that CYP19 plays a similar role in ovary development. However, the factors that up-regulate their expression remain to be identified...
- Polymorphisms in steroid hormone biosynthesis genes and risk of breast cancer and fibrocystic breast conditions in Chinese womenLori C Sakoda
Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
Cancer Epidemiol Biomarkers Prev 17:1066-73. 2008..Our findings support the possibility that common allelic variation at the CYP11A1 D15S520 locus alters breast cancer risk in Chinese women...
- PSA and androgen-related gene (AR, CYP17, and CYP19) polymorphisms and the risk of adenocarcinoma at prostate biopsyRodrigo Mattos dos Santos
Institute of Biosciences, Sao Paulo State University, UNESP, Botucatu, Sao Paulo, Brazil
DNA Cell Biol 27:497-503. 2008..Taken together, these findings suggest that the PSA genotype should be a clinically relevant biomarker to predict the PCa risk...
- In vitro modulation of steroidogenesis and gene expression by melatonin: a study with porcine antral folliclesV S Tanavde
Department of Molecular Endocrinology, National Institute for Research in Reproductive Health, ICMR, Mumbai, India
Endocr Res 29:399-410. 2003..Our results indicate that melatonin modulates ovarian theca cell steroidogenesis at the molecular level and this modulation may be mediated by its effects on the transcriptional activity of the steroidogenic enzymes...
- Polymorphisms in the P450 c17 (17-hydroxylase/17,20-Lyase) and P450 c19 (aromatase) genes: association with serum sex steroid concentrations and bone mineral density in postmenopausal womenJohn Somner
Department of Chemical Pathology, St Thomas Hospital, London, SE1 7EH United Kingdom
J Clin Endocrinol Metab 89:344-51. 2004..012). Subjects with the CC genotype had significantly lower BMD (mean +/- SD: TT, 0.7 +/- 0.16; CC, 0.6 +/- 0.08 g/cm(2); P = 0.006). In conclusion, both CYP 17 and CYP 19 are candidate genes for osteoporosis in postmenopausal women...
- [Genetic determinants of anatomical variants of the prostate]H Hamadeh
CeRePP EA3104, Universite Paris VII, Paris, France
Prog Urol 18:214-22. 2008..The authors evaluated the correlation between specific gene polymorphisms involved in androgen and oestrogen synthesis and gross (prostatic weight) and microscopic anatomy (stroma/epithelium ratio) of the prostate during ageing...
- The identification of two CYP17 alleles in the South African Angora goatKarl Heinz Storbeck
Department of Biochemistry, University of Stellenbosch, Slenbosch, South Africa
Drug Metab Rev 39:467-80. 2007..Our data implicates CYP17 as the primary cause of the observed hypoadrenocorticoidism in the South African Angora goat...
- Hormonally active nontransformed human ovarian cell culture from oophorectomy specimens: methods of development and initial characterizationDonna Seto-Young
Division of Endocrinology, Department of Medicine, Beth Israel Medical Center and Albert Einstein College of Medicine, NY 10003, USA
Horm Res 64:238-47. 2005....
- Identifying susceptibility genes for prostate cancer--a family-based association study of polymorphisms in CYP17, CYP19, CYP11A1, and LH-betaJulie A Douglas
Department of Human Genetics, University of Michigan, Room 5912, Buhl Building, Ann Arbor, MI 48109 0618, USA
Cancer Epidemiol Biomarkers Prev 14:2035-9. 2005....
- A hepatocarcinogenic tryptophan-pyrolyzate component, Trp-P-1, decreases serum total testosterone level and induces hepatic Cyp1a2 in male miceMasakuni Degawa
Department of Molecular Toxicology and the COE Program in the 21st Century, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
Cancer Sci 97:32-7. 2006....
- Patterns of expression of steroidogenic enzymes during the first wave of the ovine estrous cycle as compared to the preovulatory follicleR Duggavathi
Department of Veterinary Biomedical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK, Canada
Anim Reprod Sci 91:345-52. 2006....
- Ovarian features of the wild collared peccary (Tayassu tajacu) from the northeastern Peruvian AmazonPedro Mayor
Department of Animal Health and Anatomy, Faculty of Veterinary, Autonomous University of Barcelona, Bellaterra, E 08193 Barcelona, Spain
Gen Comp Endocrinol 147:268-75. 2006..This suggests that the corpora lutea seems to remain steroidogenically active throughout pregnancy and likely contribute to progesterone production during pregnancy...
- Triphenyltin and Tributyltin inhibit pig testicular 17beta-hydroxysteroid dehydrogenase activity and suppress testicular testosterone biosynthesisShuji Ohno
Department of Biochemistry, Hoshi University College of Pharmacy and Pharmaceutical Sciences, 2 4 41 Ebara, Shinagawa ku, Tokyo 142 8501, Japan
Steroids 70:645-51. 2005..Based on these results, it appears possible that the effects of TBT and TPT are largely due to direct inhibition of 17beta-HSD activity in vivo...
- Use of organ culture to study the human fetal testis development: effect of retinoic acidRomain Lambrot
Institut National de la Santé et de la Recherche Médicale U 566, Commissariat a l Energie Atomique, Universite Paris 7, Route du Panorama BP 6, 92265 Fontenay aux Roses Cedex, France
J Clin Endocrinol Metab 91:2696-703. 2006..In human, the chronology of the testicular development has been extensively studied, but the factors implicated in the onset and the regulation of gametogenesis and steroidogenesis remain hardly known...
- Immunolocalization of steroidogenic enzymes P450scc, 3betaHSD, P450c17, and P450arom in Göttingen miniature pig testesQiang Weng
Faculty of Biological Science and Technology, Beijing Forestry University, China
J Reprod Dev 51:299-304. 2005..These results suggested that adult GM pig testes have the ability to produce germ cells throughout the year, and the synthesis of progestin, androgen and estrogen occurs in the Leydig cells of GM pig testes...
- Endogenous estrogens inhibit mouse fetal Leydig cell development via estrogen receptor alphaGeraldine Delbes
Unité de Gamétogenèse et Génotoxicité, Institut National de la Sante et de la Recherche Medicale Unite 566, Commissariat a l Energie Atomique, Universite Paris 7, Denis Diderot, Fontenay aux Roses, France
Endocrinology 146:2454-61. 2005..Thus, this study shows that endogenous estrogens physiologically inhibit steroidogenesis via ER alpha by acting directly on the testis early in fetal and neonatal development...
- Changes in mRNAs encoding steroidogenic acute regulatory protein, steroidogenic enzymes and receptors for gonadotropins during spermatogenesis in rainbow trout testesM Kusakabe
School of Aquatic and Fishery Sciences, University of Washington, 1140 Boat Street NE, Seattle, Washington 98195 5020, USA
J Endocrinol 189:541-54. 2006....
- Variants in estrogen biosynthesis genes, sex steroid hormone levels, and endometrial cancer: a HuGE reviewSara H Olson
Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA
Am J Epidemiol 165:235-45. 2007..Larger studies or combined studies that allow for investigation of gene-gene and gene-environment interactions are warranted...
- Effects of dietary fats and proteins on rat testicular steroidogenic enzymes and serum testosterone levelsMark J McVey
Toxicology Research Division, Health Products and Foods Branch, Food Directorate, Health Canada, Sir Fredrick G Banting Research Centre, 2202D1 Tunney s Pasture, Ottawa, ON, Canada K1A 0L2
Food Chem Toxicol 46:259-69. 2008....
- Elevated expression of P450c17 (CYP17) during testicular formation in the frogRyosuke Iwade
Department of Biology, Faculty of Education and Integrated Arts and Sciences, Waseda University, 1 6 1 Nishi Waseda, Shinjuku ku, Tokyo 169 8050, Japan
Gen Comp Endocrinol 155:79-87. 2008..Taken together, the results suggest that CYP17 is very involved in testicular differentiation of the gonad in R. rugosa...
- Presence of sex steroids and cytochrome P450 genes in amphioxusTakanobu Mizuta
Center for Advanced Marine Research, Ocean Research Institute, University of Tokyo, Nakano, Tokyo 164 8639, Japan
Endocrinology 148:3554-65. 2007..This study is the first evidence to suggest the presence of CYP enzymes in sex steroid production in invertebrates...
- Testicular toxicity of profenofos in matured male ratsGihan Gamal Moustafa
Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, N18, W9, Kita ku, Sapporo, 060 0818, Japan
Arch Toxicol 81:875-81. 2007..Furthermore, we propose that the above three steroidogenic-related genes and the gene of acrosomal reaction as potential biomarkers of testicular toxicity...
- Developmental expression of key steroidogenic enzymes in the brain of protandrous black porgy fish, Acanthopagrus schlegeliS Tomy
Department of Aquaculture, National Taiwan Ocean University, Keelung, Taiwan
J Neuroendocrinol 19:643-55. 2007..The study suggests an important role for brain aromatase in male black porgy brain sex differentiation, and considers the possibility of a role for this enzyme in neurogenesis...
- Serum sex steroid hormone levels and polymorphisms of CYP17 and SRD5A2: implication for prostate cancer riskH Kakinuma
Department of Urology, Akita University School of Medicine, 1 1 1 Hondo, Akita 010 8543, Japan
Prostate Cancer Prostatic Dis 7:333-7. 2004..The linear trends across the CYP17 genotypes in serum-free testosterone and androstenedione levels were found, suggesting the importance of the polymorphism of CYP17 in determining the circulating androgen levels...
- Disorders of androgen synthesis--from cholesterol to dehydroepiandrosteroneWalter L Miller
Department of Pediatrics, University of California, San Francisco, California 94142 0978, USA
Med Princ Pract 14:58-68. 2005..Mutations of POR are a new, recently described disorder manifesting as the Antley-Bixler skeletal dysplasia syndrome, and a form of polycystic ovary syndrome...
- Spermatogenesis, serum testosterone levels and immunolocalization of steroidogenic enzymes in the wild male Japanese black bear (Ursus thibetanus japonicus)Tsukasa Okano
United Graduate School of Veterinary Medicine, Gifu University
J Vet Med Sci 65:1093-9. 2003..Leydig cells, Sertoli cells and germ cells have the capability of synthesizing androgen, and Leydig cells, Sertoli cells, spermatids and spermatogonia have the capability of synthesizing estrogen in Japanese black bears...
- Purification of cytochromes P-450(scc) and P-450(17 alpha) by steroid-binding affinity column chromatographyM Kuwada
Department of Biochemistry, School of Medicine, Kitasato University, 1-15-1 Kitasato, Sagamihara, Kanagawa 228-0829, Japan
J Biochem Biophys Methods 49:417-31. 2001..Cytochromes P-450(scc) and P-450(17 alpha) were determined to have isoelectric points of 8.0 and 6.5 in isoelectric focusing on a pH gradient gel. Cytochrome P-450s can be purified between 425- and 1000-fold from the crude extracts...
- Prostate carcinoma risk and allelic variants of genes involved in androgen biosynthesis and metabolism pathwaysA G Latil
Center for Research into Prostate Pathologies, Evry, France
Cancer 92:1130-7. 2001..The authors evaluated the association between polymorphisms in genes involved in the androgen biosynthesis and metabolism pathway and the risk of prostate carcinoma...
- Liver receptor homologue-1 is expressed in human steroidogenic tissues and activates transcription of genes encoding steroidogenic enzymesR Sirianni
Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, University of Texas Southwestern Medical Center, Dallas, Texas, USA
J Endocrinol 174:R13-7. 2002..Of the promoters examined only HSD3B2 was more sensitive to LRH than SF1. The high level of ovarian and testicular LRH expression make it likely that LRH plays an important role in the regulation of gonadal function...
- Immunoelectron microscopic localization of three key steroidogenic enzymes (cytochrome P450(scc), 3 beta-hydroxysteroid dehydrogenase and cytochrome P450(c17)) in rat adrenal cortex and gonadsG Pelletier
Oncology and Molecular Endocrinology Research Center, Laval University Medical Center CHUL, and Laval University, Quebec, Canada G1V 4G2
J Endocrinol 171:373-83. 2001....
- Normal onset, but prolonged expression, of Sry gene in the B6.YDOM sex-reversed mouse gonadC H Lee
Urology Research Laboratory, Royal Victoria Hospital, Montreal, Canada
Dev Biol 165:442-52. 1994..YDOM gonad appears to be impaired downstream of Sry transcription, resulting in persistent Sry transcripts and a delay in onset of other genes involved in testicular differentiation...
- Regulation of microsomal P450, redox partner proteins, and steroidogenesis in the developing testes of the neonatal pigF M Moran
Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, California 95616 8743, USA
Endocrinology 143:3361-9. 2002..Neither P450c17 nor P450arom can account for the decline in total microsomal P450. Reductase and cytochrome b(5) expression appears to be constitutive, but reductase levels saturate both P450c17 and P450arom...
- Influence of cytokines and growth factors on distinct steroidogenic enzymes in vitro: a short tabular data collectionM Herrmann
Institute of Sports and Preventive Medicine, University of Saarland, 66041 Saarbrucken, Germany
Ann N Y Acad Sci 966:166-86. 2002..This collection summarizes the current information on how the mentioned cytokines and growth factors influence particular enzyme steps...
- Estrogen receptor-alpha mediates an intraovarian negative feedback loop on thecal cell steroidogenesis via modulation of Cyp17a1 (cytochrome P450, steroid 17alpha-hydroxylase/17,20 lyase) expressionFuminori Taniguchi
Department of Obstetrics and Gynecology, Tottori University Hospital, Yonago, Japan
FASEB J 21:586-95. 2007..Hence, these findings provide novel evidence of an intraovarian ER alpha function that may be critical to the latter stages of folliculogenesis and overall ovarian function...
- Adrenocorticotrophic hormone (ACTH) stimulation of sheep fetal adrenal cortex can occur without increased expression of ACTH receptor (ACTH-R) mRNAA M Carter
Department of Physiology and Pharmacology, University of Southern Denmark, Odense
Reprod Fertil Dev 14:1-6. 2002..It was concluded that ACTH is able to increase plasma cortisol concentrations in the sheep fetus by up-regulating cortisol synthesis in the adrenal gland, but that in vivo this does not require up-regulation of ACTH-R mRNA...
- CYP17 genetic polymorphism in endometrial cancer: are only steroids involved?Lev M Berstein
Laboratory of Oncoendocrinology, Prof N N Petrov Research Institute of Oncology, Pesochny 2, St Petersburg, Russia
Cancer Lett 180:47-53. 2002..A1/A1 CYP17 variant may be associated with untraditional (non-steroidal) pathways that calls for corresponding preventive measures in high-risk groups...
- 17beta-estradiol treatment decreases steroidogenic enzyme messenger ribonucleic acid levels in the rainbow trout testisM Govoroun
Institut National de la Recherche Agronomique, Laboratoire Institut National de la Recherche Agronomique-Station Commune de Recherches en Ichtyophysiologie, , Campus de Beaulieu, 35042 Rennes Cedex, France
Endocrinology 142:1841-8. 2001..The decrease in P45011beta mRNA, and thus inhibition of the synthesis of testicular 11-oxygenated androgens, may be an important step required for the active feminization of these genetic males...
- Metformin directly inhibits androgen production in human thecal cellsG R Attia
Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75235-9032, USA
Fertil Steril 76:517-24. 2001..CONCLUSION(S): Our results suggest that metformin may have a direct effect on thecal cells' androgen production...
- Developmental changes in localization of steroid synthesis enzymes in camelid placentaF B P Wooding
Physiology Department, Cambridge University, Downing Street, Cambridge CB2 3EG, UK
Reproduction 126:239-47. 2003....
- Human skin is a steroidogenic tissue: steroidogenic enzymes and cofactors are expressed in epidermis, normal sebocytes, and an immortalized sebocyte cell line (SEB-1)Diane Thiboutot
Department of Dermatology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
J Invest Dermatol 120:905-14. 2003..These data demonstrate that the skin is in fact a steroidogenic tissue. The clinical significance of this finding in mediating androgenic skin disorders such as acne, hirsutism, or androgenetic alopecia remains to be established...
- Loss of oocytes in Dazl knockout mice results in maintained ovarian steroidogenic function but altered gonadotropin secretion in adult animalsJ R McNeilly
Medical Research Council Human Reproductive Sciences Unit, University of Edinburgh Center for Reproductive Biology, Scotland
Endocrinology 141:4284-94. 2000..Furthermore, in the +/- mice, the enhanced plasma inhibin B implies a role for Dazl protein within the oocyte either from more small follicles or increased inhibin B production from each follicle...
- Autoantibodies to steroidogenic enzymes in patients with premature ovarian failure with and without Addison's diseaseC Dal Pra
Chair of Clinical Immunology and Allergy, Division of Endocrinology, Department of Medical and Surgical Sciences, University of Padua, Via Ospedale 105, Padua, Italy
Eur J Endocrinol 148:565-70. 2003....
- RU-486 inhibits rat gonadal steroidogenesisP E Sanchez
Developmental Endocrinology Branch, National Institute of Child Health and Human Development, Bethesda, Maryland
Horm Metab Res 21:369-71. 1989..Ovarian 17-hydroxylase but not 3 beta-hydroxysteroid dehydrogenase activity was decreased in the animals receiving the drug. We conclude that RU-486 inhibits both testicular and ovarian steroidogenesis in the rat...
- Steroidogenic enzyme expression in the rat cochleaEric Lecain
LNRS, UMR 7060, Faculté Lariboisière, Hopital Lariboisiere, Paris, France
Acta Otolaryngol 123:187-91. 2003..We thus hypothesized that local production of steroids in the inner ear may regulate cochlear fluid exchanges...
- Normal prenatal but arrested postnatal sexual development of luteinizing hormone receptor knockout (LuRKO) miceF P Zhang
Department of Physiology, Institute of Biomedicine, University of Turku FIN 20520, Turku, Finland
Mol Endocrinol 15:172-83. 2001....
- A STUDY OF TROPIC HORMONE ACTION IN CARCINOMA CELLSJ Mason; Fiscal Year: 1990..These findings will provide insight into the interdependent actions and mechanisms of endocrine paracrine, and autocrine factors to alter differentiated cell function...
- Fusion Proteins As Probes of P450 Structure and FunctionRichard Auchus; Fiscal Year: 2004..In addition, this approach might be generally applicable to structural studies of membrane-bound proteins. ..
- ESTROGEN, DIET, GENETICS AND ENDOMETRIAL CANCERSara Olson; Fiscal Year: 2005..This study will provide data on genetic susceptibility in endometrial cancer in conjunction with established risk factors, as well as the first epidemiologic data on the more lethal serous and clear cell tumors. ..
- A Genome-Wide Association Study of Non-Hodgkin LymphomaChristine F Skibola; Fiscal Year: 2010..The data generated from this study will provide a framework for further investigation within the NHL consortium, InterLymph. Results will later be combined with that from other InterLymph case-control studies in pooled analyses. ..
- New Paradigms of P450-mediated Steroids MetabolismAlan Conley; Fiscal Year: 2006..abstract_text> ..
- MENOPAUSAL TRANSITION: A BIOBEHAVIORAL MODEL OF SYMPTOMSEllen Mitchell; Fiscal Year: 2006..abstract_text> ..
- ANDROGEN PRODUCTION IN ADRENARCHE AND PCOSWALTER MILLER; Fiscal Year: 2006..abstract_text> ..
- A Comprehensive Analysis of Genetic Variation in DNA Repair Genes in Relation toChristopher Haiman; Fiscal Year: 2007..The ability to accurately identify high-risk sub-groups may have profound implications on endometrial cancer prevention as well as advance research aimed at targeted drug development. [unreadable] [unreadable] [unreadable]..
- Lung cancer molecular markers by sex: intergroup studyChristine Ambrosone; Fiscal Year: 2008..Results from this study, the largest to date to evaluate biomarkers of susceptibility and effect, will likely elucidate reasons for the rise in lung cancer, particularly adenocarcinomas, in smoking and non-smoking women. ..
- DIETARY AND GENETIC DETERMINANTS OF MAMMOGRAPHIC DENSITYAnna Wu; Fiscal Year: 2008..abstract_text> ..
- GENETIC EPIDEMIOLOGY OF PROSTATE CANCERJanet Stanford; Fiscal Year: 2008..abstract_text> ..
- A genomic scan of hereditary prostate cancer families with an occurrence of colonJanet Stanford; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- The Role of Hormone Polymorphisms in Menstrual Function and FertilityCHANLEY SMALL; Fiscal Year: 2008..The proposed pilot study is an efficient use of existing data and biological specimens to explore these relationships among a subset of important genes in reproductive function. [unreadable] [unreadable] [unreadable]..
- Inflammatory Pathway Gene Polymorphisms and Risk of Prostate CancerJanet Stanford; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Fine-mapping of 8q24 and Loci Identified in Genome-Wide Studies for Breast & ColoCHRISTOPHER ALAN HAIMAN; Fiscal Year: 2010..We expect findings from this work to guide the development of future preventive, early detection and prognostic strategies ..
- 17 alpha-Hydroxylase Expression in Human Ovarian CellsJan M McAllister; Fiscal Year: 2010..Results of these studies will provide both new insights regarding the cause and molecular basis for increased ovarian androgen production, and lead to the development of new targets for treatment of women with PCOS. ..
- REDUCTASE INTERACTIONS GOVERNING AROMATASE ACTIVITIESAlan Conley; Fiscal Year: 2001..abstract_text> ..
- GENETIC STUDIES OF MINERALOCORTICOID FUNCTIONDavid Geller; Fiscal Year: 2004....
- Oncogenic Human Papillomaviruses & Prostate Cancer RiskJanet Stanford; Fiscal Year: 2002..If there is an association, the results will have important public health implications since both the exposure and the disease are common. ..
- Pharmacogenetics: Breast Cancer Treatment and PrognosisChristine Ambrosone; Fiscal Year: 2005..Individualized dosing according to genotype could contribute to increased efficacy and decreased toxicity among patients being treated for cancer. ..
- Naturopathic Treatments: Effects on Estrogen MetabolismHeather Greenlee; Fiscal Year: 2003..Data will be collected and analyzed on changes in estrogen rations and hormone profiles. ..
- Glucocorticoid Effects on Blood Pressure RegulationDavid Geller; Fiscal Year: 2004....
- GENETIC POLYMORPHISMS IN THE GSTPI LOCUS AND PROSTATE CAJanet Stanford; Fiscal Year: 2001....
- PREGNANCY CHANGES IN UTERINE ARTERY SIGNALING PATHWAYSIan Bird; Fiscal Year: 2004..abstract_text> ..
- Antioxidant supplements, genetics, and chemotherapy outcomesChristine Ambrosone; Fiscal Year: 2009....
- REGULATION OF MIS TYPE II RECEPTOR AND TARGET GENESJose Teixeira; Fiscal Year: 2002....
- MECHANISMS OF PREGNANCY INDUCED AT 1 RECEPTOR EXPRESSIONIan Bird; Fiscal Year: 2001..Aim 3 is to determine in vitro whether changes in expression result from changes in phospholipase C and PGI2 production. ..
- GENETIC POLYMORPHISMS AND PROSTATE CANCER RISKJanet Stanford; Fiscal Year: 2001..abstract_text> ..
- NSAIDS and Other Medications in Prostate Cancer EtiologyJanet Stanford; Fiscal Year: 2005..Results of the study may provide unique insights on the pathogenesis of this complex disease and lead to innovative strategies for prostate cancer prevention. ..
- Race & Risk Factors for Early/Aggressive Breast CancerChristine Ambrosone; Fiscal Year: 2008..Results from this study will provide much-needed answers as to why African-American women are more likely than Caucasians to be diagnosed with more aggressive disease at an earlier age. ..
- Neurosteroids and Smith-Lemli-Optiz SyndromeCedric Shackleton; Fiscal Year: 2005..All studies will require high sensitivity steroid analysis by chemical ionization (CI) GC/MS and HPLC/MS. ..
- AUSTRALASIAN COLORECTAL CANCER FAMILY REGISTRYJohn Hopper; Fiscal Year: 2007..i ..
- SMITH-LEMLI-OPITZ SYNDROME STEROIDOGENESISCedric Shackleton; Fiscal Year: 2002..Finally, if ring B dehydrosteroids are produced, is the ratio of the individual dehydrometabolites to corresponding conventional metabolites related to the dehydrocholesterol to cholesterol ratio and clinical severity? ..
- Gas chromatograph-mass spectrometer with EI and CICedric Shackleton; Fiscal Year: 2003..g., malondialdehyde) and markers of DNA damage (incorporation of uracil). Dr Kuypers has several projects on the red cell membrane, which require profiling of fatty acids using EI GC/MS. ..