aromatase

Summary

Summary: An enzyme that catalyzes the desaturation (aromatization) of the ring A of C19 androgens and converts them to C18 estrogens. In this process, the 19-methyl is removed. This enzyme is membrane-bound, located in the endoplasmic reticulum of estrogen-producing cells of ovaries, placenta, testes, adipose, and brain tissues. Aromatase is encoded by the CYP19 gene, and functions in complex with NADPH-FERRIHEMOPROTEIN REDUCTASE in the cytochrome P-450 system.

Top Publications

  1. pmc Whole-genome analysis informs breast cancer response to aromatase inhibition
    Matthew J Ellis
    Department of Internal Medicine, Division of Oncology, Washington University, St Louis, Missouri 63110, USA
    Nature 486:353-60. 2012
  2. pmc DNA methylation of the gonadal aromatase (cyp19a) promoter is involved in temperature-dependent sex ratio shifts in the European sea bass
    Laia Navarro-Martín
    Institut de Ciencies del Mar, Consejo Superior de Investigaciones Cientificas CSIC, Barcelona, Spain
    PLoS Genet 7:e1002447. 2011
  3. ncbi Sources of estrogen and their importance
    E R Simpson
    Monash Medical Center, Prince Henry s Institute of Medical Research, PO Box 5152, Clayton 3168, Vic, Australia
    J Steroid Biochem Mol Biol 86:225-30. 2003
  4. ncbi Aromatase mRNA in the extragonadal tissues of chickens with the henny-feathering trait is derived from a distinctive promoter structure that contains a segment of a retroviral long terminal repeat. Functional organization of the Sebright, Leghorn, and Cam
    H Matsumine
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235 8857
    J Biol Chem 266:19900-7. 1991
  5. ncbi Just how conserved is vertebrate sex determination?
    Andrew Cutting
    Murdoch Childrens Research Institute, Royal Childrens Hospital, Parkville, Australia
    Dev Dyn 242:380-7. 2013
  6. ncbi Interference of endocrine disrupting chemicals with aromatase CYP19 expression or activity, and consequences for reproduction of teleost fish
    Ksenia Cheshenko
    Eawag, Swiss Federal Institute of Aquatic Science and Technology, Ueberlandstrasse 133, Postfach 611, CH 8600 Dubendorf, Switzerland
    Gen Comp Endocrinol 155:31-62. 2008
  7. ncbi Aromatase deficiency in male and female siblings caused by a novel mutation and the physiological role of estrogens
    A Morishima
    Department of Pediatrics, Columbia University College of Physicians and Surgeons, New York, New York, USA
    J Clin Endocrinol Metab 80:3689-98. 1995
  8. pmc Aromatase expression in the ovary: hormonal and molecular regulation
    Carlos Stocco
    Department of Obstetrics, Gynecology and Reproductive Science, Yale University School of Medicine, 333 Cedar Street, PO 208063, New Haven, CT 06520, USA
    Steroids 73:473-87. 2008
  9. ncbi Ovarian aromatase and estrogens: a pivotal role for gonadal sex differentiation and sex change in fish
    Yann Guiguen
    INRA, UR1037 SCRIBE, IFR140, Ouest genopole, F 35000 Rennes, France
    Gen Comp Endocrinol 165:352-66. 2010
  10. ncbi Aromatase inhibitors in human lung cancer therapy
    Olga K Weinberg
    Department of Medicine, University of California at Los Angeles School of Medicine, 90095, USA
    Cancer Res 65:11287-91. 2005

Detail Information

Publications375 found, 100 shown here

  1. pmc Whole-genome analysis informs breast cancer response to aromatase inhibition
    Matthew J Ellis
    Department of Internal Medicine, Division of Oncology, Washington University, St Louis, Missouri 63110, USA
    Nature 486:353-60. 2012
    ..somatic alterations, we studied pretreatment tumour biopsies accrued from patients in two studies of neoadjuvant aromatase inhibitor therapy by massively parallel sequencing and analysis...
  2. pmc DNA methylation of the gonadal aromatase (cyp19a) promoter is involved in temperature-dependent sex ratio shifts in the European sea bass
    Laia Navarro-Martín
    Institut de Ciencies del Mar, Consejo Superior de Investigaciones Cientificas CSIC, Barcelona, Spain
    PLoS Genet 7:e1002447. 2011
    ..gonads form, that juvenile males have double the DNA methylation levels of females in the promoter of gonadal aromatase (cyp19a), the enzyme that converts androgens into estrogens...
  3. ncbi Sources of estrogen and their importance
    E R Simpson
    Monash Medical Center, Prince Henry s Institute of Medical Research, PO Box 5152, Clayton 3168, Vic, Australia
    J Steroid Biochem Mol Biol 86:225-30. 2003
    ..The importance of this unique aspect of the tissue-specific regulation of aromatase expression lies in the fact that the low circulating levels of estrogens which are observed in postmenopausal ..
  4. ncbi Aromatase mRNA in the extragonadal tissues of chickens with the henny-feathering trait is derived from a distinctive promoter structure that contains a segment of a retroviral long terminal repeat. Functional organization of the Sebright, Leghorn, and Cam
    H Matsumine
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235 8857
    J Biol Chem 266:19900-7. 1991
    The henny-feathering trait is an autosomal dominant mutation that causes the expression of aromatase activity and accumulation of aromatase mRNA in extragonadal tissues of chickens...
  5. ncbi Just how conserved is vertebrate sex determination?
    Andrew Cutting
    Murdoch Childrens Research Institute, Royal Childrens Hospital, Parkville, Australia
    Dev Dyn 242:380-7. 2013
    ..At the gonadal level, key genes required for proper sexual differentiation are conserved among vertebrates, but their relative positions in the ovarian and testicular cascades differ...
  6. ncbi Interference of endocrine disrupting chemicals with aromatase CYP19 expression or activity, and consequences for reproduction of teleost fish
    Ksenia Cheshenko
    Eawag, Swiss Federal Institute of Aquatic Science and Technology, Ueberlandstrasse 133, Postfach 611, CH 8600 Dubendorf, Switzerland
    Gen Comp Endocrinol 155:31-62. 2008
    ..At the final step of estrogen biosynthesis, cytochrome P450 aromatase, encoded by the cyp19 gene, converts androgens into estrogens...
  7. ncbi Aromatase deficiency in male and female siblings caused by a novel mutation and the physiological role of estrogens
    A Morishima
    Department of Pediatrics, Columbia University College of Physicians and Surgeons, New York, New York, USA
    J Clin Endocrinol Metab 80:3689-98. 1995
    The aromatase enzyme complex catalyzes the conversion of androgens to estrogens in a wide variety of tissues, including the ovary, testis, placenta, brain, and adipose tissue...
  8. pmc Aromatase expression in the ovary: hormonal and molecular regulation
    Carlos Stocco
    Department of Obstetrics, Gynecology and Reproductive Science, Yale University School of Medicine, 333 Cedar Street, PO 208063, New Haven, CT 06520, USA
    Steroids 73:473-87. 2008
    Estrogens are synthesized by the aromatase enzyme encoded by the Cyp19a1 gene, which contains an unusually large regulatory region...
  9. ncbi Ovarian aromatase and estrogens: a pivotal role for gonadal sex differentiation and sex change in fish
    Yann Guiguen
    INRA, UR1037 SCRIBE, IFR140, Ouest genopole, F 35000 Rennes, France
    Gen Comp Endocrinol 165:352-66. 2010
    The present review focuses on the roles of estrogens and aromatase (Cyp19a1a), the enzyme needed for their synthesis, in fish gonadal sex differentiation...
  10. ncbi Aromatase inhibitors in human lung cancer therapy
    Olga K Weinberg
    Department of Medicine, University of California at Los Angeles School of Medicine, 90095, USA
    Cancer Res 65:11287-91. 2005
    ..progression, and this steroidal growth-stimulatory pathway may be promoted by tumor expression and activity of aromatase, an estrogen synthase...
  11. pmc Micro-RNA378 (miR-378) regulates ovarian estradiol production by targeting aromatase
    Shengyu Xu
    Department of Animal and Poultry Science, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    Endocrinology 152:3941-51. 2011
    ..Owing to the importance of aromatase in the production of estradiol, the regulation of aromatase gene expression at the transcriptional level has ..
  12. ncbi Insulin-like growth factor-I, regulating aromatase expression through steroidogenic factor 1, supports estrogen-dependent tumor Leydig cell proliferation
    Rosa Sirianni
    Department of Pharmaco Biology, University of Calabria, Arcavacata di Rende, Cosenza, Italy
    Cancer Res 67:8368-77. 2007
    ..Both experimental models express high levels of aromatase and estrogen receptor alpha (ERalpha)...
  13. pmc Aromatase is a direct target of FOXL2: C134W in granulosa cell tumors via a single highly conserved binding site in the ovarian specific promoter
    Nicholas I Fleming
    Prince Henry s Institute of Medical Research, Clayton, Victoria, Australia
    PLoS ONE 5:e14389. 2010
    Granulosa cell tumors (GCT) of the ovary often express aromatase and synthesize estrogen, which in turn may influence their progression...
  14. ncbi Foxl2 up-regulates aromatase gene transcription in a female-specific manner by binding to the promoter as well as interacting with ad4 binding protein/steroidogenic factor 1
    De Shou Wang
    Laboratory of Reproductive Biology, Department of Developmental Biology, National Institute for Basic Biology, Okazaki 444 8585, Japan
    Mol Endocrinol 21:712-25. 2007
    ..has investigated the plausible role of Foxl2 in ovarian differentiation through transcriptional regulation of aromatase gene, using monosex fry of tilapia...
  15. ncbi Correlation of aromatase and cyclooxygenase gene expression in human breast cancer specimens
    R W Brueggemeier
    College of Pharmacy, The Ohio State University, Columbus 43210 1291, USA
    Cancer Lett 140:27-35. 1999
    b>Aromatase, the enzyme system catalyzing estrogen biosynthesis, is found in stromal tissue in the breast...
  16. pmc Structural basis for androgen specificity and oestrogen synthesis in human aromatase
    Debashis Ghosh
    Structural Biology, Hauptman Woodward Medical Research Institute, 700 Ellicott Street, Buffalo, New York 14203, USA
    Nature 457:219-23. 2009
    b>Aromatase cytochrome P450 is the only enzyme in vertebrates known to catalyse the biosynthesis of all oestrogens from androgens. Aromatase inhibitors therefore constitute a frontline therapy for oestrogen-dependent breast cancer...
  17. pmc Follicle-stimulating hormone/cAMP regulation of aromatase gene expression requires beta-catenin
    Tehnaz N Parakh
    School of Molecular Biosciences, Washington State University, Pullman, WA 99164, USA
    Proc Natl Acad Sci U S A 103:12435-40. 2006
    ..of estradiol in women are controlled by follicle-stimulating hormone (FSH), which regulates transcription of the aromatase gene (CYP19A1) in ovarian granulosa cells...
  18. pmc Aromatase, breast cancer and obesity: a complex interaction
    Serdar E Bulun
    Division of Reproductive Biology Research, Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Trends Endocrinol Metab 23:83-9. 2012
    Obesity has been associated with abnormally high expression of the enzyme aromatase in the breast, increased local estrogen production, and predisposition to breast hyperplasia and cancer...
  19. pmc Kinetic analysis of the three-step steroid aromatase reaction of human cytochrome P450 19A1
    Christal D Sohl
    Department of Biochemistry and Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146, USA
    J Biol Chem 285:17734-43. 2010
    Cytochrome P450 19A1 (P450 19A1), the aromatase, catalyzes the conversion of androgens to estrogens through a sequential three-step reaction, generating 19-hydroxy and 19-aldehyde intermediates en route to the product estrogen...
  20. ncbi Inhibition of testicular steroidogenesis by the xenoestrogen bisphenol A is associated with reduced pituitary luteinizing hormone secretion and decreased steroidogenic enzyme gene expression in rat Leydig cells
    Benson T Akingbemi
    Center for Biomedical Research, The Population Council, 1230 York Avenue, New York, NY 10021, USA
    Endocrinology 145:592-603. 2004
    ..d BPA, respectively, from 21-35 d of age (P < 0.05) due to its ability to inhibit Leydig cell aromatase activity. Exposures of pregnant and nursing dams, i.e...
  21. ncbi Dysmetabolic syndrome in a man with a novel mutation of the aromatase gene: effects of testosterone, alendronate, and estradiol treatment
    Laura Maffei
    Consultorios Asociados de Endocrinologia, 1425 Buenos Aires, Argentina
    J Clin Endocrinol Metab 89:61-70. 2004
    We present the fourth case of an adult man (29 yr old) affected by aromatase deficiency resulting from a novel homozygous inactivating mutation of the CYP19 (P450(arom)) gene...
  22. ncbi Genome-wide analysis of aromatase inhibitor-resistant, tamoxifen-resistant, and long-term estrogen-deprived cells reveals a role for estrogen receptor
    Selma Masri
    Department of Surgical Research, Division of Information Sciences, Beckman Research Institute of the City of Hope, Duarte, California, USA
    Cancer Res 68:4910-8. 2008
    Acquired resistance to either tamoxifen or aromatase inhibitors (AI) develops after prolonged treatment in a majority of hormone-responsive breast cancers...
  23. ncbi Genetic variation at the CYP19A1 locus predicts circulating estrogen levels but not breast cancer risk in postmenopausal women
    Christopher A Haiman
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90033, USA
    Cancer Res 67:1893-7. 2007
    The CYP19A1 gene encodes the enzyme aromatase, which is responsible for the final step in the biosynthesis of estrogens...
  24. pmc Aromatase-deficient (ArKO) mice have a phenotype of increased adiposity
    M E Jones
    Prince Henry s Institute of Medical Research, Clayton, Victoria 3168, Australia
    Proc Natl Acad Sci U S A 97:12735-40. 2000
    The aromatase-knockout (ArKO) mouse provides a useful model to examine the role that estrogens play in development and homeostasis in mammals...
  25. ncbi Doublesex- and Mab-3-related transcription factor-1 repression of aromatase transcription, a possible mechanism favoring the male pathway in tilapia
    De Shou Wang
    Key Laboratory of Freshwater Fish Reproduction and Development Ministry of Education, School of Life Science, Southwest University, 400715 Chongqing, People s Republic of China
    Endocrinology 151:1331-40. 2010
    ..Our recent studies have shown that Forkhead-l2 up-regulated transcription of the Cyp19a1a gene (aromatase) in the gonads in a female-specific manner...
  26. ncbi The human CYP19 (aromatase P450) gene: update on physiologic roles and genomic organization of promoters
    Serdar E Bulun
    Department of Obstetrics and Gynecology and Molecular Genetics, University of Illinois at Chicago, 820 S Wood St M C 808, Chicago, IL 60612, USA
    J Steroid Biochem Mol Biol 86:219-24. 2003
    ..g. GATA-2. We hypothesize that this promoter may upregulate aromatase expression in vascular endothelial cells. The in vivo cellular distribution and physiologic roles of promoter I...
  27. ncbi Altered structure and function of reproductive organs in transgenic male mice overexpressing human aromatase
    X Li
    Department of Anatomy, Institute of Biomedicine, University of Turku, Finland
    Endocrinology 142:2435-42. 2001
    ..In the present study, we generated transgenic mice (AROM(+)) bearing the human ubiquitin C promoter/human P450 aromatase fusion gene...
  28. ncbi Single nucleotide polymorphisms of the aromatase gene (CYP19A1), HER2/neu status, and prognosis in breast cancer patients
    Peter Andreas Fasching
    University Breast Center for Franconia, Department of Gynecology and Obstetrics, Erlangen University Hospital, Erlangen, Germany
    Breast Cancer Res Treat 112:89-98. 2008
    ..b>Aromatase is involved in the production of estrogens, and altered expression of it might be associated with the prognosis...
  29. ncbi Is brain estradiol a hormone or a neurotransmitter?
    Jacques Balthazart
    Center for Cellular and Molecular Neurobiology, University of Liege, B 4000 Liege, Belgium
    Trends Neurosci 29:241-9. 2006
    ..In parallel, recent studies indicate that aromatase, the enzyme that converts testosterone to estradiol in the brain, is expressed in presynaptic terminals and ..
  30. pmc Expression and sequence evolution of aromatase cyp19a1 and other sexual development genes in East African cichlid fishes
    Astrid Böhne
    Zoological Institute, University of Basel, Basel, Switzerland
    Mol Biol Evol 30:2268-85. 2013
    ..We then focus on a particularly striking case, the A- and B-copies of the aromatase cyp19a1, and detect different evolutionary trajectories: cyp19a1A evolved under strong positive selection, ..
  31. ncbi Androgen metabolism and biotransformation in nontumoral and malignant human liver tissues and cells
    Orazia M Granata
    Experimental Oncology, Department of Oncology, M Ascoli Cancer Hospital Center, ARNAS Civico, Piazzale N Leotta 2, Palermo, Italy
    J Steroid Biochem Mol Biol 113:290-5. 2009
    ..Interestingly, a significant extent of estrogen formation could be observed in Huh7 cells (5.4-11.5%), while no aromatase activity could be detected in HA22T cells...
  32. ncbi Role of transforming growth factor-beta1 in gene expression and activity of estradiol and progesterone-generating enzymes in FSH-stimulated bovine granulosa cells
    Xiaofeng Zheng
    Faculte de Medecine Veterinaire, Centre de Recherche en Reproduction Animale CRRA, Universite de Montreal, St Hyacinthe, Quebec, Canada
    Reproduction 136:447-57. 2008
    ..6 days with 1 ng/ml FSH) increased E(2) secretion and mRNA expression of E(2)-related enzymes cytochrome P450 aromatase (CYP19A1) and 17beta-hydroxysteroid dehydrogenase type 1 (HSD17B1), but not HSD17B7...
  33. ncbi Exclusion of Wilms tumour (WT1b) and ovarian cytochrome P450 aromatase (CYP19A1) as candidates for sex determination genes in Nile tilapia (Oreochromis niloticus)
    B Y Lee
    Hubbard Center for Genome Studies, University of New Hampshire, 35 Colovos Road, Durham, NH 03824, USA
    Anim Genet 38:85-6. 2007
  34. ncbi Characterization of endocrine-disrupting chemicals based on hormonal balance disruption in male and female adult rats
    Nadia Quignot
    Experimental Toxicology Unit, INERIS, Parc Technologique ALATA, 60550 Verneuil en Halatte, France
    Reprod Toxicol 33:339-52. 2012
    ..Remarkably, we observed different aromatase regulation profiles between animals with similar estrogen-to-androgen ratios but with different chemical ..
  35. pmc Expression of estrogenicity genes in a lineage cell culture model of human breast cancer progression
    Jiaqi Fu
    Institute of Environmental Health Sciences, Wayne State University, Detroit, MI, 48201, USA
    Breast Cancer Res Treat 120:35-45. 2010
    ..enzymes including cytosolic sulfotransferases (SULT1E1, SULT1A1, SULT2A1, and SULT2B1), steroid sulfatase (STS), aromatase (CYP19), 17beta-hydroxysteroid dehydrogenases (17betaHSD1 and 2), CYP1B1, and catechol-O-methyltransferase (COMT)..
  36. ncbi Analysis of the p450 aromatase gene expression in the Xenopus brain and gonad
    Junshin Iwabuchi
    Department of Chemistry, College of Humanities and Sciences, Nihon University, Sakurajosui, Setagaya Ku, Tokyo 156 8550, Japan
    J Steroid Biochem Mol Biol 107:149-55. 2007
    ..Since all cDNAs contained an identical open reading frame, it is considered that while Xenopus aromatase may be encoded by a single Cyp19 gene, it is transcribed by tissue-specific promoters, each of which may be ..
  37. pmc Peroxisome proliferator-activated receptor-gamma mediates bisphenol A inhibition of FSH-stimulated IGF-1, aromatase, and estradiol in human granulosa cells
    Jakub Kwintkiewicz
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco, San Francisco, California, USA
    Environ Health Perspect 118:400-6. 2010
    ..Bisphenol A (BPA), a chemical used as a plasticizer, is a potent endocrine disruptor that, even in low concentrations, disturbs normal development and functions of reproductive organs in different species...
  38. pmc Aromatase expression and role of estrogens in male gonad : a review
    Serge Carreau
    Department of Biochemistry, University, Esplanade de la Paix, Caen, France
    Reprod Biol Endocrinol 1:35. 2003
    ..convert irreversibly androgens into estrogens is related to the presence of a microsomal enzymatic complex named aromatase, which is composed of a specific glycoprotein, the cytochrome P450 aromatase (P450arom) and an ubiquitous ..
  39. ncbi Insulin-lowering treatment reduces aromatase activity in response to follicle-stimulating hormone in women with polycystic ovary syndrome
    Antonio La Marca
    Department of Obstetrics and Gynecology, University of Siena, Siena, Italy
    Fertil Steril 78:1234-9. 2002
    To investigate the effects of reduction of insulin resistance and hyperinsulinemia associated with the polycystic ovary syndrome (PCOS) on FSH-stimulated ovarian aromatase activity.
  40. ncbi Analysis of zebrafish cyp19 promoters
    Sok Keng Tong
    Institute of Molecular Biology 48, Academia Sinica, Nankang, Taipei 115, Taiwan, ROC
    J Steroid Biochem Mol Biol 86:381-6. 2003
    Cyp19 encodes P450 aromatase, the key enzyme catalyzing the conversion of androgens into estrogens. Estrogens play a crucial role in the anatomical, functional and behavioral characteristics of sexually dimorphic development...
  41. ncbi Single nucleotide polymorphisms of CYP19A1 predict clinical outcomes and adverse events associated with letrozole in patients with metastatic breast cancer
    In Hae Park
    Center for Breast Cancer, National Cancer Center, 323 Ilsan ro, Ilsandong gu, Goyang si, Gyeonggi do 410 769, Korea
    Cancer Chemother Pharmacol 68:1263-71. 2011
    The CYP19A1 gene encodes the aromatase enzyme involved in the peripheral conversion of androgen to estrogen...
  42. ncbi Effects of aromatase or estrogen receptor gene deletion on masculinization of the principal nucleus of the bed nucleus of the stria terminalis of mice
    Shinji Tsukahara
    Division of Life Science, Graduate School of Science and Engineering, Saitama University, Saitama City, Japan
    Neuroendocrinology 94:137-47. 2011
    ..To assess the roles of neuroestrogen synthesized from testicular androgen by brain aromatase in masculinization of the BNSTp, we performed morphometrical analyses of the adult BNSTp in aromatase knockout (..
  43. pmc Inflammation and increased aromatase expression occur in the breast tissue of obese women with breast cancer
    Patrick G Morris
    Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Cancer Prev Res (Phila) 4:1021-9. 2011
    ..Recently, we found increased numbers of CLS, activation of the NF-κB transcription factor, and elevated aromatase levels and activity in the mammary glands of obese mice...
  44. ncbi Research resource: small RNA-seq of human granulosa cells reveals miRNAs in FSHR and aromatase genes
    Agne Velthut-Meikas
    Competence Centre on Reproductive Medicine and Biology, Tiigi 61b, 50410 Tartu, Estonia
    Mol Endocrinol 27:1128-41. 2013
    ..Two of the nine novel miRNAs found were of intronic origin: one from the aromatase and the other from the FSH receptor gene. The latter miRNA was predicted to target the activin signaling pathway...
  45. ncbi Expression of LRH-1 and SF-1 in the mouse ovary: localization in different cell types correlates with differing function
    Margaret M Hinshelwood
    Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX, 75390 9038, USA
    Mol Cell Endocrinol 207:39-45. 2003
    ..Based on these findings, we propose that LRH-1 plays an important role as a competence factor in regulating aromatase, and thus estrogen biosynthesis, in ovary.
  46. ncbi Aromatase inhibitor treatment of breast cancer cells increases the expression of let-7f, a microRNA targeting CYP19A1
    Yukiko Shibahara
    Department of Pathology, Tohoku University Graduate School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai, Miyagi 980 8575, Japan
    J Pathol 227:357-66. 2012
    b>Aromatase inhibitors (AIs) are considered the gold standard of endocrine therapy for oestrogen receptor-positive postmenopausal breast cancer patients...
  47. ncbi Estrogens and PTP1B function in a novel pathway to regulate aromatase enzymatic activity in breast cancer cells
    Ines Barone
    Departments of Cell Biology, University of Calabria, Cosenza, Italy
    Endocrinology 153:5157-66. 2012
    Local estrogen production by aromatase is an important mechanism of autocrine stimulation in hormone-dependent breast cancer...
  48. pmc Aromatase, aromatase inhibitors, and breast cancer
    Saranya Chumsri
    Department of Medicine, University of Maryland School of Medicine, and the Greenebaum Cancer Center, Baltimore, MD 21201, USA
    J Steroid Biochem Mol Biol 125:13-22. 2011
    ..As aromatase catalyzes the final and rate-limiting step in the biosynthesis of estrogen, inhibitors of this enzyme are ..
  49. pmc Aromatase (CYP19) promoter gene polymorphism and risk of nonviral hepatitis-related hepatocellular carcinoma
    Woon Puay Koh
    Department of Epidemiology and Public Health, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Cancer 117:3383-92. 2011
    ..Androgens are converted to estrogens by the CYP19 gene product, aromatase. Hepatic aromatase level and activity have been shown to be markedly elevated in HCC...
  50. pmc Functional activation of the estrogen receptor-α and aromatase by the HDAC inhibitor entinostat sensitizes ER-negative tumors to letrozole
    Gauri J Sabnis
    Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine and University of Maryland Greenebaum Cancer Center, Baltimore, Maryland 21201, USA
    Cancer Res 71:1893-903. 2011
    ..the ability of the histone deacetylase inhibitor entinostat (ENT) to trigger reexpression of ERα and aromatase in breast cancer cells, with the notion that this treatment would restore sensitivity to the aromatase inhibitor ..
  51. ncbi Progressive development of insulin resistance phenotype in male mice with complete aromatase (CYP19) deficiency
    K Takeda
    Department of Clinical Laboratory Medicine, Kochi Medical School, Kohasu, Okocho, Nankoku City, Kochi 783 8505, Japan
    J Endocrinol 176:237-46. 2003
    b>Aromatase (CYP19) is a cytochrome P450 enzyme that catalyzes the formation of aromatic C18 estrogens from C19 androgens. It is expressed in various tissues and contributes to sex-specific differences in cellular metabolism...
  52. ncbi The mechanism of sex determination in vertebrates-are sex steroids the key-factor?
    Masahisa Nakamura
    Department of Biology, Faculty of Education and Integrated Arts and Sciences, Waseda University, Shinjuku ku, Tokyo, Japan
    J Exp Zool A Ecol Genet Physiol 313:381-98. 2010
    ..For such sex-reversal, a functioning sex-determining gene is not required. However, in R. rugosa CYP19 (P450 aromatase) is expressed at high levels in indifferent gonads before phenotypic sex determination, and the gene is also ..
  53. pmc Estrogen regulation of testicular function
    Benson T Akingbemi
    Department of Anatomy, Physiology and Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, AL 36849, USA
    Reprod Biol Endocrinol 3:51. 2005
    ..These studies fall into three categories: i) localization of aromatase and the target protein for estrogen (ER-alpha and ER-beta) in tissues of the reproductive tract; ii) analysis of ..
  54. ncbi Melatonin inhibits the growth of DMBA-induced mammary tumors by decreasing the local biosynthesis of estrogens through the modulation of aromatase activity
    Samuel Cos
    Department of Physiology and Pharmacology, School of Medicine, University of Cantabria, Santander, Spain
    Int J Cancer 118:274-8. 2006
    ..Recently, we described that melatonin reduces aromatase expression and activity in MCF-7 human breast cancer cells, thus modulating the local estrogen biosynthesis...
  55. ncbi Aromatase expression in ovarian epithelial cancers
    S Cunat
    Laboratoire de Biologie Cellulaire et Hormonale, Centre Hospitalier Universitaire de Montpellier, Hopital Arnaud de Villeneuve, 34295 Montpellier Cedex 5, France
    J Steroid Biochem Mol Biol 93:15-24. 2005
    Our study focused on aromatase cytochrome P450 (CYP19) expression in ovarian epithelial normal and cancer cells and tissues...
  56. ncbi Estrogen-related receptor alpha in human breast carcinoma as a potent prognostic factor
    Takashi Suzuki
    Department of Pathology, Tohoku University School of Medicine, Sendai, Japan
    Cancer Res 64:4670-6. 2004
    ..Results from our study suggest that ERRalpha possibly modulates the expression of ERE-containing estrogen-responsive genes, and ERRalpha immunoreactivity is a potent prognostic factor in human breast carcinoma...
  57. ncbi Polymorphisms associated with circulating sex hormone levels in postmenopausal women
    Alison M Dunning
    Cancer Research UK, Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK
    J Natl Cancer Inst 96:936-45. 2004
    ..We investigated the association between levels of sex hormones and single nucleotide polymorphisms (SNPs) in genes coding for the enzymes that regulate them...
  58. pmc Aromatase gene polymorphisms are associated with survival among patients with cardiovascular disease in a sex-specific manner
    Amber L Beitelshees
    Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, College Park, Maryland, United States of America
    PLoS ONE 5:e15180. 2010
    CYP19A1 encodes aromatase, the enzyme responsible for the conversion of androgens to estrogens, and may play a role in variation in outcomes among men and women with cardiovascular disease...
  59. pmc Bisphenol A exposure during adulthood alters expression of aromatase and 5α-reductase isozymes in rat prostate
    Beatriz Castro
    Department of Biochemistry and Molecular Biology, School of Medicine, University of Granada, Granada, Spain
    PLoS ONE 8:e55905. 2013
    ..ventral prostate the effects of adult exposure to BPA on 5α-Reductase isozymes (5α-R types 1, 2, and 3) and aromatase, key enzymes in the biosynthesis of dihydrotestosterone and estradiol, respectively...
  60. pmc Association of two common single-nucleotide polymorphisms in the CYP19A1 locus and ovarian cancer risk
    Marc T Goodman
    Cancer Epidemiology Program, Cancer Research Center of Hawaii, Honolulu, Hawaii, USA
    Endocr Relat Cancer 15:1055-60. 2008
    ..The production of estrogen involves the conversion of androgens via P450 aromatase, encoded by the CYP19A1 gene...
  61. pmc Estrogenic encounters: how interactions between aromatase and the environment modulate aggression
    Brian C Trainor
    Department of Psychology, Ohio State University, Columbus, 43210, USA
    Front Neuroendocrinol 27:170-9. 2006
    ..may be due to differential metabolism of T within the brain, in particular, the conversion of T to estrogen by aromatase. Thus, differences in aromatase enzyme activity, estrogen receptor expression, and related cofactors may have ..
  62. ncbi Endocrine disrupter bisphenol A increases in situ estrogen production in the mouse urogenital sinus
    Shigeki Arase
    Department of Nephro Urologic Surgery and Andrology, Mie University Graduate School of Medicine, Mie, Japan
    Biol Reprod 84:734-42. 2011
    ..In the BPA-treated UGS, estradiol (E(2)) levels and CYP19A1 (cytochrome P450 aromatase) activity were significantly increased compared with those of the untreated and diethylstilbestrol (DES)-treated ..
  63. ncbi Modulation of human CYP19A1 activity by mutant NADPH P450 oxidoreductase
    Amit V Pandey
    Pediatric Endocrinology and Diabetology, University of Bern, Freiburgstrasse 15, G3 812, CH 3010 Bern, Switzerland
    Mol Endocrinol 21:2579-95. 2007
    ..Because POR supports many P450s involved in steroidogenesis, bone formation, and drug metabolism, variations in the effects of POR mutations on specific enzyme activities may explain the broad clinical spectrum of POR deficiency...
  64. pmc Sex hormone receptor gene polymorphisms and migraine: a systematic review and meta-analysis
    Markus Schürks
    Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215 1204, USA
    Cephalalgia 30:1306-28. 2010
    ..Data on the association between sex hormone receptor polymorphisms and migraine are conflicting...
  65. ncbi Is aromatase expression in the endometrium the cause of endometriosis and related infertility?
    Hugo Maia
    Centro de Pesquisas e Assistencia em Reproducao Humana CEPARH, Bahia, Brazil
    Gynecol Endocrinol 25:253-7. 2009
    b>Aromatase expression in the endometrium seems to play a pivotal role in the development of endometriotic lesions...
  66. ncbi Endometrial aromatase mRNA as a possible screening tool for advanced endometriosis and adenomyosis
    Jozef Hatok
    Department of Medical Biochemistry, Jessenius Faculty of Medicine, Comenius University in Bratislava, Mala Hora 4, 036 01 Martin, Slovak Republic
    Gynecol Endocrinol 27:331-6. 2011
    ..The aim of this study was to determine the clinical usefulness of examining endometrial biopsy specimens for aromatase cytochrome P450 (CYP19) as a diagnostic importance for endometriosis and adenomyosis...
  67. ncbi Tamoxifen metabolites as active inhibitors of aromatase in the treatment of breast cancer
    Wenjie Jessie Lu
    Division of Clinical Pharmacology, Department of Pharmacology and Toxicology, Indiana University Simon Cancer Center, Indiana University School of Medicine, 1001 West 10th Street, Room 7123, Myers Building, Indianapolis, IN 46202, USA
    Breast Cancer Res Treat 131:473-81. 2012
    ..also by reduced estrogen synthesis, we tested the ability of tamoxifen and its principal metabolites to inhibit aromatase in vitro...
  68. ncbi Enantioselective nonsteroidal aromatase inhibitors identified through a multidisciplinary medicinal chemistry approach
    Andrea Cavalli
    Department of Pharmaceutical Sciences, University of Bologna, Via Belmeloro, 6, I 40126 Bologna, Italy
    J Med Chem 48:7282-9. 2005
    To identify enantioselective nonsteroidal aromatase inhibitors, a multidisciplinary medicinal chemistry approach was pursued. First, our earlier CoMFA model [Bioorg. Med. Chem...
  69. ncbi A novel mutation in the human aromatase gene: insights on the relationship among serum estradiol, longitudinal growth and bone mineral density in an adult man under estrogen replacement treatment
    Fabio Lanfranco
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Turin, Italy
    Bone 43:628-35. 2008
    Here we report on a new case of human aromatase deficiency in a man of 26 years of age and present the results of five year follow-up during trandermal estradiol (tE2) substitution, focusing on bone growth and mineralization...
  70. ncbi Aromatase inhibitors in breast cancer
    Stephen Hiscox
    Welsh School of Pharmacy, Cardiff University, Cardiff, UK
    Maturitas 63:275-9. 2009
    ..treatments are evolving that target estrogen production in postmenopausal tissues through inhibition of the aromatase enzyme...
  71. ncbi Aromatase in the brain of teleost fish: expression, regulation and putative functions
    Nicolas Diotel
    Neurogenesis And OEstrogens, UMR CNRS 6026, IFR 140, Universite de Rennes 1, Rennes, France
    Front Neuroendocrinol 31:172-92. 2010
    Unlike that of mammals, the brain of teleost fish exhibits an intense aromatase activity due to the strong expression of one of two aromatase genes (aromatase A or cyp19a1a and aromatase B or cyp19a1b) that arose from a gene duplication ..
  72. ncbi Characterization and expression pattern of zebrafish Anti-Müllerian hormone (Amh) relative to sox9a, sox9b, and cyp19a1a, during gonad development
    Adriana Rodriguez-Mari
    Institute of Neuroscience, University of Oregon, Eugene, 97403, USA
    Gene Expr Patterns 5:655-67. 2005
    ..expression of Amh, which initiates the regression of the Mullerian ducts and inhibits the expression of aromatase (Cyp19a1), the enzyme that converts androgens to estrogens...
  73. pmc Tissue-selective regulation of aromatase expression by calcitriol: implications for breast cancer therapy
    Aruna V Krishnan
    Department of Medicine, Division of Endocrinology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, California 94305 5103, USA
    Endocrinology 151:32-42. 2010
    b>Aromatase, the enzyme that catalyzes estrogen synthesis, is critical for the progression of estrogen receptor-positive breast cancer (BCa) in postmenopausal women...
  74. ncbi The influence of inflammatory cytokines on estrogen production and cell proliferation in human breast cancer cells
    Susumu Honma
    Department of Obstetrics and Gynecology, Showa University School of Medicine, Shinagawa ku, Tokyo 142 8666, Japan
    Endocr J 49:371-7. 2002
    ..In the present study, we investigated the effects of inflammatory cytokines on aromatase (Arom) and steroid sulfatase (STS), which are estrogen-producing enzymes, and cell proliferation using human ..
  75. ncbi Anti-Müllerian hormone and 11 beta-hydroxylase show reciprocal expression to that of aromatase in the transforming gonad of zebrafish males
    X G Wang
    Reproductive Genomics, Temasek Life Sciences Laboratory, and Department of Biological Sciences, National University of Singapore, Singapore
    Dev Dyn 236:1329-38. 2007
    ..from a vas::egfp transgenic line and used for gene expression analysis of anti-Müllerian hormone (amh), ovarian aromatase (cyp19a1a) and 11 beta-hydroxylase (cyp11b, also known as P450(11 beta)) by real-time polymerase chain reaction ..
  76. pmc Development and evolution of therapies targeted to the estrogen receptor for the treatment and prevention of breast cancer
    V Craig Jordan
    Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111 2497, United States
    Steroids 72:7-25. 2007
    ..Developing drugs that target the estrogen receptor (ER) either directly (tamoxifen) or indirectly (aromatase inhibitors) has improved the prognosis of breast cancer and significantly advanced healthcare...
  77. ncbi Estradiol stimulates progenitor cell division in the ventricular and subventricular zones of the embryonic neocortex
    Veronica Martinez-Cerdeno
    Department of Neurology and Program in Developmental and Stem Cell Biology, 513 Parnassus Avenue, HSW 1201, Box 0525, University of California San Francisco, San Francisco, California 94143, USA
    Eur J Neurosci 24:3475-88. 2006
    ..We show that aromatase, the E2 synthesizing enzyme, is present in the embryonic neocortex, that estrogen receptor-alpha is present in ..
  78. ncbi Involvement of estrogens in the process of sex differentiation in two fish species: the rainbow trout (Oncorhynchus mykiss) and a tilapia (Oreochromis niloticus)
    Y Guiguen
    INRA Institut National de la recherche Agronomique, Rennes, Cedex, France
    Mol Reprod Dev 54:154-62. 1999
    ..In vivo treatments with an aromatase inhibitor (ATD, 1,4,6- androstatriene-3-17-dione) result in 100% masculinization of an all-female population in ..
  79. ncbi Aromatase activity and bone homeostasis in men
    Luigi Gennari
    Department of Internal Medicine, Endocrine Metabolic Sciences, and Biochemistry, University of Siena, Siena 53100, Italy
    J Clin Endocrinol Metab 89:5898-907. 2004
    ..Human models of aromatase deficiency were the first to demonstrate the critical importance of the conversion of circulating androgens into ..
  80. pmc High aromatase expression in uterine leiomyoma tissues of African-American women
    Hiroshi Ishikawa
    Division of Reproductive Biology Research, Robert H Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL 60611, USA
    J Clin Endocrinol Metab 94:1752-6. 2009
    ..African-American women develop uterine leiomyomas at an earlier age and with higher frequency compared with Caucasian-American women or other races; however, the underlying mechanism for this discrepancy is unknown...
  81. ncbi A cyp19a1b-gfp (aromatase B) transgenic zebrafish line that expresses GFP in radial glial cells
    Sok Keng Tong
    Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan
    Genesis 47:67-73. 2009
    b>Aromatase is an enzyme that catalyzes the synthesis of estrogen in gonads and brain. Teleost fish express aromatase (AroB) strongly in the brain facilitating its detailed examination...
  82. pmc The role of cytokines in regulating estrogen synthesis: implications for the etiology of breast cancer
    Atul Purohit
    Faculty of Medicine, Imperial College, St Mary s Hospital, London, UK
    Breast Cancer Res 4:65-9. 2002
    ..The activities of the aromatase, estradiol 17beta-hydroxysteroid dehydrogenase and estrone sulfatase are all increased by IL-6 and TNF-alpha...
  83. pmc Obesity is associated with inflammation and elevated aromatase expression in the mouse mammary gland
    Kotha Subbaramaiah
    Department of Medicine and Weill Cornell Cancer Center, New York, NY 10065, USA
    Cancer Prev Res (Phila) 4:329-46. 2011
    ..Following menopause, the biosynthesis of estrogens through CYP19 (aromatase)-mediated metabolism of androgen precursors occurs primarily in adipose tissue, and the resulting estrogens are ..
  84. ncbi Aromatase cytochrome P450 and extragonadal estrogen play a role in ischemic neuroprotection
    Louise D McCullough
    Department of Neurology and Anesthesiology, Johns Hopkins School of Medicine, Baltimore, Maryland 21287 4961, USA
    J Neurosci 23:8701-5. 2003
    ..We hypothesized that estradiol aromatized from precursor androgens via the cytochrome P450 aromatase contributes to ischemic neuroprotection in the female...
  85. pmc Functional genetic polymorphisms in the aromatase gene CYP19 vary the response of breast cancer patients to neoadjuvant therapy with aromatase inhibitors
    Liewei Wang
    Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota 55905, USA
    Cancer Res 70:319-28. 2010
    b>Aromatase (CYP19) is a critical enzyme in estrogen biosynthesis and aromatase inhibitors (AI) are employed widely for endocrine therapy in postmenopausal women with breast cancer...
  86. ncbi History of aromatase: saga of an important biological mediator and therapeutic target
    R J Santen
    University of Virginia Health System, Division of Endocrinology, P O Box 801416, Charlottesville, Virginia 22908, USA
    Endocr Rev 30:343-75. 2009
    b>Aromatase is the enzyme that catalyzes the conversion of androgens to estrogens. Initial studies of its enzymatic activity and function took place in an environment focused on estrogen as a component of the birth control pill...
  87. ncbi Aromatase inhibitors in the treatment of breast cancer
    Robert W Brueggemeier
    College of Pharmacy, The Ohio State University, 500 West 12th Avenue, Columbus, Ohio 43210 1291, USA
    Endocr Rev 26:331-45. 2005
    ..most potent endogenous estrogen, is biosynthesized from androgens by the cytochrome P450 enzyme complex called aromatase. Aromatase is present in breast tissue, and intratumoral aromatase is the source of local estrogen production in ..
  88. ncbi Transcriptional activation of steroidogenic factor-1 by hypomethylation of the 5' CpG island in endometriosis
    Qing Xue
    Division of Reproductive Biology Research, Department of Obstetrics and Gynecology, Northwestern University, Chicago, Illinois 60611, USA
    J Clin Endocrinol Metab 92:3261-7. 2007
    ....
  89. ncbi Of mice and men: the evolving phenotype of aromatase deficiency
    Margaret E E Jones
    Prince Henry s Institute of Medical Research, PO Box 5152, Clayton, Victoria 3168, Australia
    Trends Endocrinol Metab 17:55-64. 2006
    ..order for estrogens to be synthesized endogenously, the enzyme responsible for their synthesis from androgens, aromatase, must be functional...
  90. ncbi Effects of aromatase mutation (ArKO) on the sexual differentiation of kisspeptin neuronal numbers and their activation by same versus opposite sex urinary pheromones
    Julie Bakker
    GIGA Neurosciences, University of Liege, B36 1st floor Avenue de l Hopital, 1 4000, Liege, Belgium
    Horm Behav 57:390-5. 2010
    ..Furthermore, we analyzed the effects of aromatase mutation (ArKO) and thus the role of estradiol on RP3V kisspeptin neuronal numbers and on the response of these ..
  91. ncbi Stimulation of aromatase P450 promoter (II) activity in endometriosis and its inhibition in endometrium are regulated by competitive binding of steroidogenic factor-1 and chicken ovalbumin upstream promoter transcription factor to the same cis-acting elem
    K Zeitoun
    Cecil H Ida Green Center for Reproductive Biology Sciences, Department of Obstetrics and Gynecology, The University of Texas Southwestern Medical Center, Dallas 75235 9051, USA
    Mol Endocrinol 13:239-53. 1999
    In stromal cells of endometriosis, marked levels of aromatase P450 (P450arom) mRNA and activity are present and can be vigorously stimulated by (Bu)2cAMP or PGE2 to give rise to physiologically significant estrogen biosynthesis...
  92. pmc Metformin inhibits aromatase via an extracellular signal-regulated kinase-mediated pathway
    Suman Rice
    Division of Basic Medical Sciences, Bachelor of Medicine, St George s, University of London, London SW17 0RE, United Kingdom
    Endocrinology 150:4794-801. 2009
    ..Granulosa luteal cells were incubated with metformin, insulin, or combined metformin and insulin treatment, and aromatase mRNA expression was quantified using real-time RT-PCR...
  93. pmc Adult male rat hippocampus synthesizes estradiol from pregnenolone by cytochromes P45017alpha and P450 aromatase localized in neurons
    Yasushi Hojo
    Department of Biophysics and Life Sciences and Core Research for Evolutional Science and Technology Project of Japan Science and Technology Corporation, Graduate School of Arts and Sciences, University of Tokyo at Komaba, Meguro, Tokyo 153, Japan
    Proc Natl Acad Sci U S A 101:865-70. 2004
    ..rat hippocampal formation, significant localization was demonstrated for both cytochromes P45017alpha and P450 aromatase, in pyramidal neurons in the CA1-CA3 regions, as well as in the granule cells in the dentate gyrus, by means of ..
  94. ncbi Aromatase deficiency confers paradoxical postischemic cardioprotection
    James R Bell
    Cardiac Phenomics Laboratory, Department of Physiology, University of Melbourne, Victoria 3010, Australia
    Endocrinology 152:4937-47. 2011
    ..Estrogen synthesis depends on androgen availability, with aromatase regulating conversion of testosterone to estradiol...
  95. pmc Aromatase, estrone sulfatase, and 17β-hydroxysteroid dehydrogenase: structure-function studies and inhibitor development
    Yanyan Hong
    Division of Tumor Cell Biology, Beckman Research Institute of the City of Hope, 1450 E Duarte Road, Duarte, CA 91010, United States
    Mol Cell Endocrinol 340:120-6. 2011
    b>Aromatase, estrone sulfatase, and 17β-hydroxysteroid dehydrogenase type 1 are involved in the key steps of 17β-estradiol biosynthesis...
  96. ncbi Aromatase and leiomyoma of the uterus
    Makio Shozu
    Department of Obstetrics and Gynecology, Kanazawa University School of Medicine, Kanazawa, Japan
    Semin Reprod Med 22:51-60. 2004
    In leiomyoma of the uterus, both aromatase and 17beta-hydroxysteroid dehydrogenase (17beta-HSD) type I are overexpressed compared with myometrium...
  97. ncbi Localization and regulation of aromatase liver receptor homologue-1 in the developing rat testis
    Jayne Sierens
    Prince Henry s Institute of Medical Research, Monash Medical Centre, 246 Clayton Road, Clayton, Victoria 3168, Australia
    Mol Cell Endocrinol 323:307-13. 2010
    The enzyme aromatase converts androgens to estrogens, which have recently been postulated to be essential for testicular development and fertility...
  98. ncbi 17alpha-estradiol induces aromatase activity in intact human anagen hair follicles ex vivo
    R Hoffmann
    Department of Dermatology, Philipp University, Deutschhausstrasse 9, D 35033 Marburg, Germany
    Exp Dermatol 11:376-80. 2002
    ..Because aromatase is involved in the conversion of testosterone to estrogens and because there is some clinical evidence that ..
  99. ncbi Steroid control and sexual differentiation of brain aromatase
    J Balthazart
    European Graduate School for Neuroscience, Laboratory of Biochemistry, University of Liege, Belgium
    J Steroid Biochem Mol Biol 61:323-39. 1997
    Brain aromatase (ARO) activity in the quail is markedly enhanced by testosterone (T)...
  100. ncbi High endometrial aromatase P450 mRNA expression is associated with poor IVF outcome
    Jan Brosens
    Institute for Reproductive and Developmental Biology, Wolfson and Weston Research Centre for Family Health, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 ONN, UK
    Hum Reprod 19:352-6. 2004
    ..b>Aromatase P450 expression in the human endometrium is thought to be restricted to women with proliferative reproductive ..
  101. ncbi Prostaglandin E2 regulates aromatase activity and expression in human adipose stromal cells via two distinct receptor subtypes
    Jeanette A Richards
    Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, Ohio State University, Columbus, Ohio 43210, USA
    J Clin Endocrinol Metab 88:2810-6. 2003
    The aromatase enzyme complex, located primarily in the stromal cells of breast tumors, catalyzes estrogen biosynthesis and is fundamental to hormone-dependent growth of breast cancer...

Research Grants76

  1. Development of VN/14-1 and Related Analogs for Breast Cancer Therapy
    VINCENT COLLINS OFUKA NJAR; Fiscal Year: 2013
    ..e., tumors that are resistant to mainstay breast cancer therapies such as tamoxifen and aromatase inhibitors) breast cancer xenograft models...
  2. A Soft Topical Antiandrogenic Drug
    Wei Chu Xu; Fiscal Year: 2013
    ..Circulating T and DHT also serve as precursors of estrogens through their conversion to estradiol and estrone by aromatase. Thus, regardless of gender, these secreted steroids are converted peripherally into divergent signals for two ..
  3. Mechanisms of Sex Determination in Zebrafish
    JOHN HARVEY POSTLETHWAIT; Fiscal Year: 2013
    ..alter the strength of an oocyte-derived signal that promotes, in surrounding somatic cells, 3) the production of aromatase, the enzyme that 4) converts testosterone to estrogen, which preserves oocytes and biases the gonad toward a ..
  4. Estrogen Modulation of Auditory Processing
    Raphael Pinaud; Fiscal Year: 2012
    ..NCM is also the site of a major overlap between the auditory and neuroendocrine systems. High levels of aromatase and estrogen receptors are found in NCM...
  5. Photoperiod Brain and Behavior
    Randy J Nelson; Fiscal Year: 2012
    ..What is the role of gonadal steroid hormones in mediating photoperiod-induced brain plasticity? We will examine aromatase activity, androgen (AR), and estrogen receptor (ER) subtype (ER1 and ER2) expression in long- vs...
  6. Theranostic Nanomedicine for Breast Cancer Prevention and Image-Guided Therapy
    Prakash R Rai; Fiscal Year: 2011
    ..and limiting toxicity of chemo-preventive agents which include selective estrogen receptor antagonists, aromatase inhibitors, retinoids, COX-2 inhibitors and metformin...
  7. RCT of exercise on aromatase inhibitor side effects in breast cancer survivors
    Melinda L Irwin; Fiscal Year: 2012
    ..the standard adjuvant hormonal therapy for women with early- stage, hormone receptor-positive breast cancer, the aromatase inhibitors (AI's) have rapidly supplanted tamoxifen as the hormonal therapy of choice...
  8. Optic Nerve Aging and Glaucoma
    Thasarat Vajaranant; Fiscal Year: 2013
    ..This training and line of research will provide a foundation for future studies investigating the effects of aromatase inhibitors, selective estrogen receptor modulators and other anti- estrogen treatments on the optic nerve...
  9. Primate Fetal Adrenal Development: Impact on Physiological Processes After Birth
    Eugene D Albrecht; Fiscal Year: 2013
    ..Using the baboon as a nonhuman primate translational model, and the aromatase inhibitor letrozole to suppress placental estrogen levels during the second half of pregnancy, we have shown ..
  10. Lifestyle and Molecular Factors of Bone Health in Breast Cancer Survivors
    Song Yao; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Aromatase inhibitors (AIs) have been rapidly replacing tamoxifen (TAM) as first-line adjuvant hormonal therapy for postmenopausal women diagnosed with hormone receptor (HR)-positive, early-stage ..
  11. A Novel Target for the Treatment of Endometriosis
    Paul D Crowe; Fiscal Year: 2011
    ..Endometriotic lesions synthesize estrogen endogenously and this may be pathologically significant. Reports that aromatase inhibitors, which block the final step of estrogen synthesis, are effective in rare cases of post-menopausal ..
  12. Theranostic Nanomedicine for Breast Cancer Prevention and Image-Guided Therapy
    Prakash R Rai; Fiscal Year: 2013
    ..and limiting toxicity of chemo-preventive agents which include selective estrogen receptor antagonists, aromatase inhibitors, retinoids, COX-2 inhibitors and metformin...
  13. Inhibiting EGFR and ER pathways in NSCLC
    Edward B Garon; Fiscal Year: 2013
    ..the clinical trial for correlative secondary endpoints, including tumor levels of ER, ER, progesterone receptor, aromatase and EGFR as well as EGFR mutations and other selected biologic markers...
  14. Acupuncture for Aromatase Inhibitor-Related Arthralgias in Breast Cancer Patients
    Dawn Hershman; Fiscal Year: 2013
    Third generation aromatase inhibitors have been shown to be superior to tamoxifen in improving disease free survival, decreasing distant and local recurrence rates and decreasing incidence of contra-lateral breast cancer in women with ..
  15. CYP19A1 gene and Pharmacogenetics of Response
    REINA C VILLAREAL; Fiscal Year: 2013
    ..Estrogen in males is mainly derived from the conversion of testosterone to estradiol by the enzyme aromatase. Polymorphisms of the aromatase gene (CYP19A1) have been reported to result in variable enzyme activity ..
  16. WNT and gonadotropin mediated regulation of ovarian steroidogenesis
    JENNIFER HERNANDEZ GIFFORD; Fiscal Year: 2010
    ..Moreover, reduction of [unreadable]-catenin in granulosa cells compromises FSH stimulation of aromatase mRNA and resultant estradiol production...
  17. Aromatase Inhibitors in Pulmonary Vascular Complications of Liver Disease
    Steven M Kawut; Fiscal Year: 2013
    ..variation in estrogen receptor &#946;was associated with the occurrence of HPS , and 3) genetic variation in aromatase was associated with both higher plasma estradiol (E2) levels and a higher risk of PPHTN...
  18. Endothelial Aromatase in Sex-Specific Cerebrovascular Dysfunction After Ischemia
    KRISTEN LEANNE ZULOAGA; Fiscal Year: 2012
    ..women, the major source of estrogen becomes local (extra-gonadal) synthesis of estradiol by the enzyme aromatase. Aromatase is expressed in numerous cell types, including vascular endothelial cells (EC)...
  19. Brain aromatase availability in steroid users: PET studies with [11C]vorozole
    Thomas B Hildebrandt; Fiscal Year: 2013
    ..By studying AAS intoxication in relation to aromatase availability, we will be able to understand functional relationships between AAS metabolism and the core ..
  20. Targeting the Obesity-Inflammation-COX-Aromatase Axis to Lower Breast Cancer Risk
    ANDREW JESS DANNENBERG; Fiscal Year: 2013
    ..from adipose tissue, since adipose tissue is the primary site of action of the estrogen-synthesizing enzyme aromatase post climacteric...
  21. CELLULAR MECHANISMS IN THE INDUCTION OF AROMATASE
    Carole R Mendelson; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Estrogen synthesis is catalyzed by aromatase P450 (product of hCYP19 gene), which is expressed at very high levels in human placenta...
  22. Estrogen signaling in portopulmonary hypertension
    Steven M Kawut; Fiscal Year: 2013
    ..We showed that variation in genes linked to estrogen signaling (aromatase and estrogen receptor alpha (ESR1)) and higher estradiol levels significantly increased the risk of PPHTN in ..
  23. The new biology of estrogen action in aromatase resistance breast cancer cells
    JOAN SUEDEE LEWIS-WAMBI; Fiscal Year: 2011
    ..PA) and I am submitting a K01 application to study the new biology of estrogen and fulvestrant action in aromatase inhibitor resistant breast cancer cells...
  24. MicroRNA Signature of Tamoxifen Resistance in Breast Cancer
    Sarmila Majumder; Fiscal Year: 2010
    ..Recently, alternative endocrine therapies, such as aromatase inhibitors (AI), are found to be more effective in estrogen receptor positive, post-menopausal women with breast ..
  25. Structure and Function of Integral Membrane Enzyme Human Aromatase
    Debashis Ghosh; Fiscal Year: 2012
    Human cytochrome P450 aromatase (P450arom), an integral membrane hemeprotein of the endoplasmic reticulum, catalyzes the synthesis of estrogens from androgens in the presence of P450-reductase...
  26. Regulation of miRNA in breast cancer
    Carolyn M Klinge; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Aromatase inhibitor therapy is not useful for all ER1 positive breast cancer patients and the selective estrogen receptor ..
  27. Medications Development for the Pregnant Opiate Addict
    Mahmoud S Ahmed; Fiscal Year: 2010
    ..The activity of aromatase and P-gp are affected by placental genotype and gestational age...
  28. Personalized therapeutics for inhibiting breast cancer metastasis
    DEBRA AUGUSTE; Fiscal Year: 2012
    ..and human epidermal growth receptor-2 (HER2) on their surface are treated with hormone (anti-estrogen or aromatase inhibitors) or targeted (Herceptin) therapies, respectively...
  29. Neurobiology of Aggression Co-morbidity in Mouse Model of Idic15 Autism
    Matthew P Anderson; Fiscal Year: 2013
    ..This testosterone is mostly converted to estradiol locally in the brain by neurons that synthesize the enzyme aromatase (cyp19)...
  30. Role of Phospho-Progesterone Receptors (PR) in Hormone Refractory Breast Cancer
    CAROL ANN LANGE; Fiscal Year: 2013
    ..Our unique phospho-PR gene signature will be validated in in vitro models of tam- and AI- (aromatase inhibitor) resistance and in human tumors (Validation;Aim 2)...
  31. Oral Health in Breast Cancer Survivors on Aromatase Inhibitors
    Linda Susan Taichman; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Aromatase inhibitors (AIs) are routinely prescribed as adjuvant hormonal therapy for postmenopausal women with hormone receptor positive breast cancer...
  32. Non-genomic actions of estrogen in breast cancer
    Ellis R Levin; Fiscal Year: 2013
    ..Whether these mechanisms underlie aromatase inhibitor resistance will also be determined...
  33. The Utility of Empiric Medical Treatment of Infertile Oligo-asthenospermic Men
    Peter R Casson; Fiscal Year: 2013
    ..EMT) treatment with either clomiphene citrate (CC;a selective estrogen receptor modulator) or letrozole (an aromatase inhibitor) in men with oligospermia has been advocated;both act by decreasing estrogen negative feedback on the ..
  34. Fractures, Heart Disease, and Stroke on Aromatase Inhibitors
    Nancy L Keating; Fiscal Year: 2010
    ..Recently, randomized controlled trials identifying substantial benefits of aromatase inhibitors for early- stage cancers have led to national recommendations that every postmenopausal woman with an ..
  35. Synaptic Aromatase: a Novel Form of Estrogen Delivery
    Colin J Saldanha; Fiscal Year: 2012
    The estrogen (E) synthetic enzyme aromatase is localized in presynaptic boutons of many vertebrates including humans...
  36. HEME PROTEIN REDUCTASES
    Stephen G Sligar; Fiscal Year: 2012
    ..keto group at the apex of the D-ring in androgens and the reaction catalyzed by the important drug target, aromatase, wherein an aromatic A-ring is formed concomitantly with cleavage of the C10-C19 bond...
  37. Epigenetic Regulation of Breast Cancer Progression by the Proto-oncogene PELP1
    MONICA MANN; Fiscal Year: 2013
    ..Endocrine therapies using tamoxifen and aromatase inhibitors substantially improve disease- free survival, however, initial or acquired resistance frequently ..
  38. Steroid Catecholamine Interactions and Behavior
    Gregory F Ball; Fiscal Year: 2013
    ..The steroid hormone testosterone is a pro-hormone that can be metabolized via the enzyme aromatase to an estrogen such as estradiol...
  39. Mechanisms of Breast Tumor Cell Growth, Motility, and Antiestrogen Response
    Amy H Bouton; Fiscal Year: 2013
    ..with hormonal therapies designed to inhibit receptor function (antiestrogens) or block production of estrogens (aromatase inhibitors)...
  40. Application of Evolutionary Principles to Maintain Cancer Control (PQ21)
    Robert A Gatenby; Fiscal Year: 2013
    ..to combine three chemotherapeutic strategies currently used in the clinic: (a) hormonal therapy (tamoxifen and aromatase inhibitors), (b) targeted therapy (herceptin), and (c) standard chemotherapy (doxorubicin and taxol)...
  41. Regulation of Aromatase Expression in the Corpus Luteum
    CARLOS OSCAR STOCCO; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The aromatase enzyme (CYP19A1) is required for the biosynthesis of estradiol, a steroid needed for normal follicular and luteal cell function and essential for reproduction...
  42. A Hypersensitive ER alpha Mutant in Breast Cancer Hormone Resistance
    Suzanne Aw Fuqua; Fiscal Year: 2012
    ..tumors re- gress but then regrow, suggesting that the mutation also confers resistance to therapies such as aromatase inhibitors (AIs)...
  43. A Neoadjuvant Trial of Anastrazole and A Novel SRC Inhibitor, AZD0530, for LABC
    JOYCE MARIE contact SLINGERLAND; Fiscal Year: 2010
    ..receptor 1 (ER) is expressed in 70% of new breast cancers but de novo and acquired resistance to tamoxifen or aromatase inhibitors (AI) limit their efficacy...
  44. Estrogen and Memory: Genetic Variation and Neuroimaging
    Susan K Conroy; Fiscal Year: 2013
    ..variation in the estrogen pathway genes ESR1 (estrogen receptor 1), ESR2 (estrogen receptor 2), and CYP19A1 (aromatase), to alterations in brain morphology, including regional volumes, gray matter densities, and cortical ..
  45. The role of the mTOR signaling pathway in ER-positive breast cancer
    MARINA KAUFMAN HOLZ; Fiscal Year: 2013
    ..ER-positive breast cancers can be targeted therapeutically by antiestrogens (such as tamoxifen) or aromatase inhibitors (AIs)...
  46. Deguelin in therapy of triple negative breast cancer
    Rajendra G Mehta; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Treatment of breast cancer patients with antiestrogens and aromatase inhibitor(s) has been successfully used for steroid receptor positive breast cancers...
  47. Mass spectrometry to decode PTM patterns and enhance the Biomarker utility of ER
    Christopher Benz; Fiscal Year: 2013
    ..ER (designated ER+), signifying that they MAY respond favorably to endocrine therapy with tamoxifen or aromatase inhibitors...
  48. Cognitive Functioning After Breast Cancer Treatment
    Patricia A Ganz; Fiscal Year: 2010
    ..surgery, radiation, chemotherapy) and who are about to initiate adjuvant endocrine therapy (with tamoxifen or aromatase inhibitors)...
  49. Role of pharmacogenetics on exemestane metabolism and toxicity
    Philip Lazarus; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Aromatase inhibitors (AIs) are widely used as adjuvant treatment for estrogen-receptor positive breast cancer in post-menopausal women...
  50. LRH-1 Antagonism: Impact on Estrogen-dependent Breast Cancer
    Marcia I Dawson; Fiscal Year: 2013
    ..In the postmenopausal cancerous breast, expression of the enzyme synthesizing estrogen (aromatase) becomes elevated, as do estrogen and the estrogen nuclear receptor (ER)...
  51. The Inositol Phosphate Cascade as a Regulator of FSH and LH actions in the Ovary
    Shawn M Breen; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The gonadotropin-induced expression of aromatase in granulosa cells is dependent on the signaling pathways that are activated, which is dictated by the density of each gonadotropin receptor...
  52. Second line breast cancer therapy through a novel Phytoantiestrogen
    SYREETA LATATIA TILGHMAN; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Although aromatase inhibitors, such as letrozole, are the standard endocrine therapy of choice for post-menopausal women with early-stage metastatic estrogen-dependent breast cancer, the major ..
  53. Role of nonnuclear estrogen receptor GPR30 in preganglionic vagal neurons
    Eugen Brailoiu; Fiscal Year: 2012
    ..identify the presence of GPR30 in cardiac projecting neurons of the nucleus ambiguus and its colocalization with aromatase. Second, measurement of heart rate and blood pressure in response to GPR30 agonists in vivo...
  54. Mechanisms of Energy Balance and Cancer Prevention
    ANNE M MCTIERNAN; Fiscal Year: 2010
    ..3 projects will examine: weight loss effects on proteomics, caloric restriction effects on adipose expression of aromatase, the intersection of gut health with systemic insulin resistance and inflammation, and biology behavior ..
  55. Regulation of hormone production by matrix proteins
    Rong Li; Fiscal Year: 2013
    ..including breast cancer, uterine fibroids, and endometriosis are associated with local overexpression of aromatase, a key enzyme in estrogen biosynthesis and important therapeutic target for postmenopausal ER+ breast cancer...
  56. Prostaglandins and Cerebellum Development
    Margaret M McCarthy; Fiscal Year: 2013
    ..restricted sensitive period leads to excess prostaglandin E2 (PGE2), a proinflammatory molecule that stimulates aromatase activity and estradiol synthesis locally within the cerebellum...
  57. Next generation bisphosphonates for chemo- and immuno-therapy
    Eric Oldfield; Fiscal Year: 2013
    ..the bisphosphonate drug zoledronate has unexpected positive effects as an adjuvant (in combination therapy with aromatase inhibitors) in breast cancer, reducing the re-occurrence of disease (at any site) by 36%, in addition to ..
  58. Novel Biomarkers for Aromatase Inhibitor Therapy
    Matthew J Ellis; Fiscal Year: 2013
    ..study) and identified both pre-treatment and on- treatment gene expression signatures that predict response to aromatase inhibitor (AI) treatment...
  59. The role of HDAC2 in hormone therapy resistance
    Pamela N Munster; Fiscal Year: 2013
    ..g. tamoxifen) or to decrease the local production of estrogen in target tissues using an aromatase inhibitor...
  60. Mechanisms Underlying SES Disparities in Breast Cancer Mortality
    Liliana E Pezzin; Fiscal Year: 2013
    ..of breast conserving surgery with radiotherapy, the choice and use of alternative adjuvant endocrine therapy (aromatase inhibitors vs. tamoxifen) and possibly persistence with endocrine therapy once initiated...
  61. Understanding the effects of estrogen signaling on fatty liver disease
    Sarah Hart-Unger; Fiscal Year: 2012
    ..concept is also supported by animal research showing increased rates of hepatic steatosis in estrogen-deficient aromatase knockout mice;furthermore, estrogen receptor knockout mice (ER1 KO) exhibit other metabolic features associated ..
  62. Metabolism of Carcinogens and Drugs by Human P450s
    F Peter Guengerich; Fiscal Year: 2013
    ..analysis of multi-reaction P450s will be done, including P450S 51Al (ianosterol 14a-demethylation), 19A1 (aromatase, oxidation of testosterone to 17p-estradiol), and 2A6 (oxidation of indoles), wrth a goal of defining the ..
  63. Aromatase Inhibitor in Males with Adrenal Hyperplasia
    Kyriakie Sarafoglou; Fiscal Year: 2006
    ..objective is to treat males who have congenital adrenal hyperplasia (CAH) and decreased spermatogenesis with an aromatase inhibitor in order to investigate its effects on hormonal parameters and spermatogenesis...
  64. Flaxseed vs. aromatase inhibitors: breast tumor characteristics and prognosis
    Susan McCann; Fiscal Year: 2009
    ..Used in postmenopausal women, aromatase inhibitors (AI) block the peripheral conversion of androgens to estrogen, effectively lowering the estradiol ..
  65. MECHANISMS OF INFERTILITY IN ENDOMETRIOSIS
    Serdar Bulun; Fiscal Year: 2002
    ..Our preliminary results are indicative that the aberrant expression of aromatase and cyclo-oxygenase (COX)-2 and the deficiency of 17beta-hydroxysteroid dehydrogenase type 2 (17beta-HSD-2) in ..
  66. BIOCHEMICAL PROBES OF THE ACTIVE SITE OF AROMATASE
    ROBERT BRUEGGEMEIER; Fiscal Year: 1993
    ..in this competing renewal application will continue and extend investigations on the utilization of selected aromatase inhibitors as biochemical tools in studying the active site of aromatase. Investigations by the P.I...
  67. Female Hormones and Vision
    Alvin Eisner; Fiscal Year: 2006
    ..The clinical emphasis will be on 2 types of medications - selective estrogen receptor modulators (SERMS) and aromatase inhibitors...
  68. OVARIAN TUMOR NECROSIS FACTOR
    Paul Terranova; Fiscal Year: 2004
    ..The second aim will determine the effects of TNF on aromatase dependent transcription factors, steroidogenic factor-1 (SF-1) and cAMP response element binding protein (CREB) ..
  69. Int5/Aromatase Effect of Breast Estrogen in Neoplasia
    RAJESHWAR TEKMAL; Fiscal Year: 2005
    A number of studies have shown that the levels of aromatase are higher in breast tumors compared to normal tissue, indicating that the in situ aromatase/breast estrogen may play a role in breast cancer...
  70. ALCOHOLIC EMBRYOPATHY & MATERNAL HYPERTENSION
    RUSSELL MANKES; Fiscal Year: 1992
    ..We will determine whether ethanol consumption is accompanied by alterations in placental aromatase activity, or whether blood and tissue levels of sex steroids, prostaglandins or thromboxane are affected by ..
  71. Relationship Between AD Clinicopathological Changes and CNS Sex Steroid Hormones
    Jeremiah Kelly; Fiscal Year: 2009
    ..to quantify brain tissue levels of sex steroid hormones and the sex steroid aromatizing enzyme cytochrome P450 aromatase in men and women enrolled in the Rush Religious Orders Study and determine their relationship to AD diagnosis, ..
  72. TESTOSTERONE EFFECTS ON GONADOTROPINS AND LIPIDS IN MEN
    CARRIE BAGATELL; Fiscal Year: 1992
    ..T is converted to DHT by the enzyme 5 alpha reductase and to E2 by the aromatase enzyme complex...
  73. Bone Content and Metabolism of Sex Steroid Hormones
    STEPHEN BORST; Fiscal Year: 2009
    ..The bone-protective effects of T may be mediated by conversion of T to estradiol by bone aromatase. Recently, young men have been identified with constitutive aromatase deficiency...
  74. AROMATASE IN ADIPOSE--RELATIONSHIP TO AGING AND CANCER
    Evan Simpson; Fiscal Year: 2005
    ..order to study the regulation of estrogen biosynthesis we have cloned and characterized the gene encoding human aromatase cytochrome P450 (P450arom), the enzyme responsible for estrogen biosynthesis...
  75. BREAST TUMOR PROXIMAL STROMA INTERACTION AND AROMATASE
    Serdar Bulun; Fiscal Year: 2000
    In postmenopausal women, the adipose fibroblast is the major site of aromatase P450 (P45Oarom) expression, which catalyzes the conversion of C19-steroids to estrogens...
  76. Association of breast cancer and its therapies with fracture
    Joan Neuner; Fiscal Year: 2009
    ..Finally, advances in adjuvant hormonal therapy with the introduction of aromatase inhibitors (AIs) suggest that osteoporosis will become a greater problem in the future...