cytochromes b

Summary

Summary: Cytochromes of the b group that have alpha-band absorption of 563-564 nm. They occur as subunits in MITOCHONDRIAL ELECTRON TRANSPORT COMPLEX III.

Top Publications

  1. pmc Identification of Birds through DNA Barcodes
    Paul D N Hebert
    Department of Zoology, University of Guelph, Guelph, Ontario, Canada
    PLoS Biol 2:e312. 2004
  2. ncbi Evolutionary relationships, cospeciation, and host switching in avian malaria parasites
    Robert E Ricklefs
    Department of Biology, University of Missouri, 8001 Natural Bridge Road, St Louis, Missouri 63121 4499, USA
    Syst Biol 53:111-9. 2004
  3. pmc Reconstructing mammalian phylogenies: a detailed comparison of the cytochrome B and cytochrome oxidase subunit I mitochondrial genes
    Shanan S Tobe
    Centre for Forensic Science, WestCHEM, Department of Pure and Applied Chemistry, University of Strathclyde, Glasgow, United Kingdom
    PLoS ONE 5:e14156. 2010
  4. ncbi A new PCR assay for simultaneous studies of Leucocytozoon, Plasmodium, and Haemoproteus from avian blood
    Olof Hellgren
    Department of Animal Ecology, Ecology Building, Lund University, SE 22362 Lund, Sweden
    J Parasitol 90:797-802. 2004
  5. ncbi Molecular markers to discriminate among four pest species of Helicoverpa (Lepidoptera: Noctuidae)
    G T Behere
    Centre for Environmental Stress and Adaptation Research, Department of Genetics, Bio 21, Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville 3010, Australia
    Bull Entomol Res 98:599-603. 2008
  6. ncbi Polymerase chain reaction-based identification of Plasmodium (Huffia) elongatum, with remarks on species identity of haemosporidian lineages deposited in GenBank
    Gediminas Valkiunas
    Institute of Ecology, Vilnius University, Akademijos 2, Vilnius LT 08412, Lithuania
    Parasitol Res 102:1185-93. 2008
  7. ncbi Phylogenetic relationships among the Ibero-African cobitids (Cobitis, cobitidae) based on cytochrome b sequence data
    Ignacio Doadrio
    Museo Nacional de Ciencias Naturales, CSIC, Jose Gutierrez Abascal 2, 28006 Madrid, Spain
    Mol Phylogenet Evol 37:484-93. 2005
  8. ncbi Genetic structure and colonization processes in European populations of the common vole, Microtus arvalis
    Gerald Heckel
    Computational and Molecular Population Genetics, Zoological Institute, University of Bern, Baltzerstrasse 6, CH 3012 Bern, Switzerland
    Evolution 59:2231-42. 2005
  9. ncbi Coalescence methods reveal the impact of vicariance on the spatial genetic structure of Elephantulus edwardii (Afrotheria, Macroscelidea)
    H A Smit
    Evolutionary Genomics Group, Department of Botany and Zoology, Stellenbosch University, Private BagX1, Matieland 7602, South Africa
    Mol Ecol 16:2680-92. 2007
  10. ncbi Calibrating the avian molecular clock
    J T Weir
    Department of Ecology and Evolution, University of Chicago, Chicago, IL 60637, USA
    Mol Ecol 17:2321-8. 2008

Research Grants

Detail Information

Publications257 found, 100 shown here

  1. pmc Identification of Birds through DNA Barcodes
    Paul D N Hebert
    Department of Zoology, University of Guelph, Guelph, Ontario, Canada
    PLoS Biol 2:e312. 2004
    ..The growing evidence for the effectiveness of DNA barcodes as a basis for species identification supports an international exercise that has recently begun to assemble a comprehensive library of COI sequences linked to named specimens...
  2. ncbi Evolutionary relationships, cospeciation, and host switching in avian malaria parasites
    Robert E Ricklefs
    Department of Biology, University of Missouri, 8001 Natural Bridge Road, St Louis, Missouri 63121 4499, USA
    Syst Biol 53:111-9. 2004
    ..Detailed studies of the phylogeographic distributions of hosts and parasites are needed to characterize these events...
  3. pmc Reconstructing mammalian phylogenies: a detailed comparison of the cytochrome B and cytochrome oxidase subunit I mitochondrial genes
    Shanan S Tobe
    Centre for Forensic Science, WestCHEM, Department of Pure and Applied Chemistry, University of Strathclyde, Glasgow, United Kingdom
    PLoS ONE 5:e14156. 2010
    ..Using a Kimura 2-parameter p-distance (x100) threshold of 1.5-2.5, cyt b gives a better resolution for separating species with a lower false positive rate and higher positive predictive value than those of COI...
  4. ncbi A new PCR assay for simultaneous studies of Leucocytozoon, Plasmodium, and Haemoproteus from avian blood
    Olof Hellgren
    Department of Animal Ecology, Ecology Building, Lund University, SE 22362 Lund, Sweden
    J Parasitol 90:797-802. 2004
    ..Although only a small number of different bird species were investigated (6 passerine species), we found 22 different parasite species lineages (4 Haemoproteus, 8 Plasmodium, and 10 Leucocytozoon)...
  5. ncbi Molecular markers to discriminate among four pest species of Helicoverpa (Lepidoptera: Noctuidae)
    G T Behere
    Centre for Environmental Stress and Adaptation Research, Department of Genetics, Bio 21, Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville 3010, Australia
    Bull Entomol Res 98:599-603. 2008
    ..This technique is fast, reliable and effective at distinguishing specimens irrespective of their life stages and offers support to conventional taxonomic differentiation based on morphological characters...
  6. ncbi Polymerase chain reaction-based identification of Plasmodium (Huffia) elongatum, with remarks on species identity of haemosporidian lineages deposited in GenBank
    Gediminas Valkiunas
    Institute of Ecology, Vilnius University, Akademijos 2, Vilnius LT 08412, Lithuania
    Parasitol Res 102:1185-93. 2008
    ..elongatum and P. relictum, respectively. Some other incorrect species identifications of avian haematozoa in GenBank have been identified. We propose a strategy to minimise the number of such mistakes in GenBank in the future...
  7. ncbi Phylogenetic relationships among the Ibero-African cobitids (Cobitis, cobitidae) based on cytochrome b sequence data
    Ignacio Doadrio
    Museo Nacional de Ciencias Naturales, CSIC, Jose Gutierrez Abascal 2, 28006 Madrid, Spain
    Mol Phylogenet Evol 37:484-93. 2005
    ..The basal polytomies of the Ibero-African Clade might suggest that all mtDNA lineages diversified rapidly...
  8. ncbi Genetic structure and colonization processes in European populations of the common vole, Microtus arvalis
    Gerald Heckel
    Computational and Molecular Population Genetics, Zoological Institute, University of Bern, Baltzerstrasse 6, CH 3012 Bern, Switzerland
    Evolution 59:2231-42. 2005
    ..This suggests that some M. arvalis populations persisted during the LGM in suitable habitat further north and that the gradients in genetic diversity may represent traces of a more ancient colonization of Europe by the species...
  9. ncbi Coalescence methods reveal the impact of vicariance on the spatial genetic structure of Elephantulus edwardii (Afrotheria, Macroscelidea)
    H A Smit
    Evolutionary Genomics Group, Department of Botany and Zoology, Stellenbosch University, Private BagX1, Matieland 7602, South Africa
    Mol Ecol 16:2680-92. 2007
    ..edwardii. Our results reveal the morphological misidentification of one of these types, accentuating the problems of field identification...
  10. ncbi Calibrating the avian molecular clock
    J T Weir
    Department of Ecology and Evolution, University of Chicago, Chicago, IL 60637, USA
    Mol Ecol 17:2321-8. 2008
    ..Minor but significant variance in rates occurred across lineages but was not explained by differences in generation time, body size or latitudinal distribution as previously suggested...
  11. ncbi Sequence variation of the cytochrome b gene of various human infecting members of the genus Leishmania and their phylogeny
    G E Luyo-Acero
    Department of Dermatology, Faculty of Medicine, University of the Ryukyus, 207 Uehara, Nishihara cho, Okinawa 903 0125, Japan
    Parasitology 128:483-91. 2004
    ..L.) major in the L. (L.) tropica complex and the placement of L. tarentolae in another genus. These data show that the Cyt b gene is useful for phylogenetic study of Leishmania parasites...
  12. pmc A chemical genomic analysis of decoquinate, a Plasmodium falciparum cytochrome b inhibitor
    Tae Gyu Nam
    Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States
    ACS Chem Biol 6:1214-22. 2011
    ..The basis for this difference was revealed by molecular docking studies, in which both of these inhibitors were shown to have distinctly different modes of binding within the ubiquinol-binding site of cytochrome b...
  13. ncbi Numts help to reconstruct the demographic history of the ocellated lizard (Lacerta lepida) in a secondary contact zone
    Andreia Miraldo
    School of Biological Sciences, University of East Anglia, Norwich NR4 7J, UK
    Mol Ecol 21:1005-18. 2012
    ..This study shows that, in the context of phylogeographic analysis, numts can provide evidence for past demographic events and can be useful tools for the reconstruction of complex evolutionary histories...
  14. ncbi Postglacial colonization of Europe by the barbastelle bat: agreement between molecular data and past predictive modelling
    Hugo Rebelo
    School of Biological Sciences, University of Bristol, Woodland Road, Bristol BS8 1UG, UK
    Mol Ecol 21:2761-74. 2012
    ..In addition, all countries sampled possessed unique gene pools, thus stressing the need for the conservation of local populations...
  15. pmc Assessment of three mitochondrial genes (16S, Cytb, CO1) for identifying species in the Praomyini tribe (Rodentia: Muridae)
    Violaine Nicolas
    Museum national d histoire naturelle, Département de Systématique et Evolution UMR CNRS 7205, Paris, France
    PLoS ONE 7:e36586. 2012
    ....
  16. pmc Cryptic diversity of African tigerfish (genus Hydrocynus) reveals palaeogeographic signatures of linked neogene geotectonic events
    Sarah A M Goodier
    Department of Molecular and Cell Biology, University of Cape Town, Rondebosch, Cape Town, South Africa
    PLoS ONE 6:e28775. 2011
    ..These events in tigerfish evolution concur broadly with available geological evidence and reveal prominent control by the African Rift System, evident in the formative events archived in phylogeographic records of tigerfish...
  17. ncbi Introgressive hybridization in southern African baboons shapes patterns of mtDNA variation
    C Keller
    Cognitive Ethology, German Primate Center, 37077 Gottingen, Germany
    Am J Phys Anthropol 142:125-36. 2010
    ....
  18. ncbi Disease in the dark: molecular characterization of Polychromophilus murinus in temperate zone bats revealed a worldwide distribution of this malaria-like disease
    A Megali
    Department of Ecology and Evolution, University of Lausanne, Le Biophore, CH 1015 Lausanne, Switzerland
    Mol Ecol 20:1039-48. 2011
    ..These haplotypes formed a well-defined clade together with Haemosporidia of tropical bats, revealing a worldwide distribution of this parasite mostly neglected by malarial studies since the 1980s...
  19. pmc Design and applicability of DNA arrays and DNA barcodes in biodiversity monitoring
    Mehrdad Hajibabaei
    Biodiversity Institute of Ontario, Department of Integrative Biology, University of Guelph, Guelph, Ontario, Canada
    BMC Biol 5:24. 2007
    ..DNA arrays (micro and macro) and DNA barcodes are two molecular approaches that have recently garnered much attention. Here, we compare these two platforms for identification of an important group, the mammals...
  20. ncbi Phylogenetic relationships of leaf monkeys (Presbytis; Colobinae) based on cytochrome b and 12S rRNA genes
    V F Vun
    School of Environmental and Natural Resource Sciences, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, Bangi, Selangor, Malaysia
    Genet Mol Res 10:368-81. 2011
    ..rubicunda, in two different clades. Cyt b and 12S rRNA are good gene candidates for the study of phylogenetic relationships at the species level. However, the systematic relationships of some subspecies in this genus remain unclear...
  21. ncbi Molecular architecture of Pipistrellus pipistrellus/Pipistrellus pygmaeus complex (Chiroptera: Vespertilionidae): further cryptic species and Mediterranean origin of the divergence
    Pavel Hulva
    Department of Zoology, Charles University, Vinicna 7, 128 44 Prague 2, Czech Republic
    Mol Phylogenet Evol 32:1023-35. 2004
    ..The paleobiographic scenario envisaged is corroborated also by molecular clock estimations and correlations with Late Neogene environmental changes in the Mediterranean region which ended with the Messinian salinity crisis...
  22. ncbi False phylogenies on wood mice due to cryptic cytochrome-b pseudogene
    Sylvain Dubey
    School of Biological Sciences, University of Sydney, Sydney, NSW 2006, Australia
    Mol Phylogenet Evol 50:633-41. 2009
    ..The presence of this cryptic pseudogene in published sequences is supported by different pathways. This has led to important errors in previous molecular trees and hence to partial misinterpretations in the phylogeny of Apodemus...
  23. ncbi Molecular systematics of the damselfishes (Teleostei: Pomacentridae): Bayesian phylogenetic analyses of mitochondrial and nuclear DNA sequences
    Brice Quenouille
    Smithsonian Tropical Research Institute, Apdo 2072, Balboa, Panama
    Mol Phylogenet Evol 31:66-88. 2004
    ....
  24. ncbi The relationship between the rate of molecular evolution and the rate of genome rearrangement in animal mitochondrial genomes
    Wei Xu
    Department of Physics and Astronomy, McMaster University, Main St West, Hamilton, Ontario, L8S 4M1, Canada
    J Mol Evol 63:375-92. 2006
    ..We discuss the possible causes of variation in rates of sequence evolution and gene rearrangement among species and the possible reasons for the observed correlation between the two rates...
  25. ncbi Phylogenic analysis of the genus Leishmania by cytochrome b gene sequencing
    Yutaka Asato
    Division of Dermatology, Unit of Organ oriented Medicine, University of the Ryukyu, 207 Uehara, Nishihara cho, Okinawa 903 0215, Japan
    Exp Parasitol 121:352-61. 2009
    ..Cyt b gene analysis is thus applicable to the analyzing phylogeny of the genus Leishmania and may be useful for separating non-human pathogenic species from human pathogenic species...
  26. pmc Phylogeography and genetic structuring of European nine-spined sticklebacks (Pungitius pungitius)-mitochondrial DNA evidence
    Amber G F Teacher
    Ecological Genetics Research Unit, Department of Biosciences, University of Helsinki, Helsinki, Finland
    PLoS ONE 6:e19476. 2011
    ....
  27. ncbi Cytochrome b mutations that modify the ubiquinol-binding pocket of the cytochrome bc1 complex and confer anti-malarial drug resistance in Saccharomyces cerevisiae
    Jacques J Kessl
    Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03755
    J Biol Chem 280:17142-8. 2005
    ..By modeling the variations in cytochrome b structure and atovaquone binding with the mutated bc1 complexes, we obtained the first quantitative explanation for the molecular basis of atovaquone resistance in malaria parasites...
  28. pmc Mitochondrial phylogeography of baboons (Papio spp.): indication for introgressive hybridization?
    Dietmar Zinner
    Cognitive Ethology, Deutsches Primatenzentrum, Gottingen, Germany
    BMC Evol Biol 9:83. 2009
    ....
  29. ncbi Comparing evolutionary patterns and variability in the mitochondrial control region and cytochrome B in three species of baleen whales
    S Elizabeth Alter
    Department of Biological Sciences, Hopkins Marine Station, Stanford University, 120 Oceanview Boulevard, Pacific Grove, CA, 93950, USA
    J Mol Evol 68:97-111. 2009
    ..These results highlight the complexity of making inferences from control region data alone and suggest that applying simple rules of DNA sequence analyses across species may be difficult...
  30. ncbi Relationships among characiform fishes inferred from analysis of nuclear and mitochondrial gene sequences
    Daniela Calcagnotto
    Division of Vertebrate Zoology, American Museum of Natural History, Central Park West at 79th St, New York, NY 10024 5192, USA
    Mol Phylogenet Evol 36:135-53. 2005
    ....
  31. ncbi New evidence for parallel evolution of colour patterns in Malagasy poison frogs (Mantella)
    Y Chiari
    Department of Biology Evolutionary Biology, University of Konstanz, D 78457 Konstanz, Germany
    Mol Ecol 13:3763-74. 2004
    ....
  32. ncbi So close and so different: comparative phylogeography of two small mammal species, the yellow-necked fieldmouse (Apodemus flavicollis) and the woodmouse (Apodemus sylvaticus) in the Western Palearctic region
    J R Michaux
    Unité de recherches zoogéographiques, Institut de Zoologie, Quai Van Beneden, 22, 4020 Liege, Belgium
    Heredity (Edinb) 94:52-63. 2005
    ..Finally, it suggests that phylogeographic distinctiveness may be a general feature of European species...
  33. ncbi Phylogeographical, ecological and biological patterns shown by nuclear (ssrRNA and gGAPDH) and mitochondrial (Cyt b) genes of trypanosomes of the subgenus Schizotrypanum parasitic in Brazilian bats
    Manzelio Cavazzana
    Departamento de Parasitologia, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Sao Paulo, SP 05508 900, Brazil
    Int J Parasitol 40:345-55. 2010
    ..Trypanosoma cruzi (18.2%) was found mainly in vespertilionid and phyllostomid bats from the Pantanal/Cerrado and the Atlantic Forest (Central to Southeast), with a few isolates from Amazonia...
  34. ncbi A new Haemoproteus species (Haemosporida: Haemoproteidae) from the endemic Galapagos dove Zenaida galapagoensis, with remarks on the parasite distribution, vectors, and molecular diagnostics
    Gediminas Valkiunas
    Institute of Ecology, Nature Research Centre, Akademijos 2, Vilnius 21, LT 08412, Lithuania
    J Parasitol 96:783-92. 2010
    ..We point to the need of using both morphology and gene markers in studies of hemosporidian parasites, particularly in wildlife...
  35. ncbi Resonance Raman quantification of the redox state of cytochromes b and c in-vivo and in-vitro
    Minoru Kakita
    Department of Chemistry, School of Science, The University of Tokyo, Hongo 7 3 1, Bunkyo, Toyo 113 0033, Japan
    J Biophotonics 5:20-4. 2012
    We observe the redox state changes with respiration of cytochromes b and c in mitochondria in a living Saccharomyces cerevisiae cell as well as in isolated mitochondria with the very use of Raman microspectroscopy...
  36. ncbi Avian haematozoan parasites and their associations with mosquitoes across Southwest Pacific Islands
    F Ishtiaq
    Edward Grey Institute, Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK
    Mol Ecol 17:4545-55. 2008
    ..Nonetheless, our results raise the possibility of a new transmission pathway and highlight extensive invertebrate host shifts in an insular mosquito-parasite system...
  37. ncbi Diversity and phylogeny of mitochondrial cytochrome B lineages from six morphospecies of avian Haemoproteus (Haemosporida: Haemoproteidae)
    Olof Hellgren
    Department of Animal Ecology, Ecology Building, Lund University, SE 22362 Lund, Sweden
    J Parasitol 93:889-96. 2007
    ..We, therefore, propose the use of a cyt. b fragment of this length as a standard gene fragment for a DNA bar-coding system for avian Haemoproteus species...
  38. pmc Variant Plasmodium ovale isolated from a patient infected in Ghana
    David Tordrup
    Department of Infectious Diseases, Institute of Clinical Medicine, Aarhus University Hospital Skejby, Aarhus N, Denmark
    Malar J 10:15. 2011
    ..ovale isolated from humans in South-East Asia and Africa, and from a chimpanzee in Cameroon. The split between the variant and classic P. ovale is estimated to have occurred 1.7 million years ago...
  39. ncbi Human disease-related mutations in cytochrome b studied in yeast
    Nicholas Fisher
    Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, United Kingdom
    J Biol Chem 279:12951-8. 2004
    ..Thus by using yeast as a model system, we identified the molecular basis of the respiratory defect caused by the disease mutations in cytochrome b...
  40. ncbi Molecular phylogeny of basidiomycetous yeasts in the Cryptococcus luteolus lineage (Tremellales) based on nuclear rRNA and mitochondrial cytochrome b gene sequence analyses: proposal of Derxomyces gen. nov. and Hannaella gen. nov., and description of eigh
    Qi Ming Wang
    Systematic Mycology and Lichenology Laboratory, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China
    FEMS Yeast Res 8:799-814. 2008
    ..3778(T)=CBS 10826(T)), Derxomyces qinlingensis (AS 2.2446(T)=CBS 10818(T)), Derxomyces simaoensis (AS 2.3571(T)=CBS 10822(T)), Derxomyces wuzhishanensis (AS 2.3760(T)=CBS 10825(T)) and Derxomyces yunnanensis (AS 2.3562(T)=CBS 10821(T))...
  41. ncbi A biogeographic view of Apodemus in Asia and Europe inferred from nuclear and mitochondrial gene sequences
    Hitoshi Suzuki
    Graduate School of Environmental Earth Science, Hokkaido University, Sapporo 060 0810, Japan
    Biochem Genet 46:329-46. 2008
    ..agrarius to Europe in the Late Quaternary...
  42. ncbi Cytochrome b gene structure and consequences for resistance to Qo inhibitor fungicides in plant pathogens
    Valeria Grasso
    Centre of Competence for Innovation in the Agro environmental Sector AGROINNOVA, University of Turin, Via L da Vinci 44, 10095 Grugliasco TO, Italy
    Pest Manag Sci 62:465-72. 2006
    ..As a consequence, the evolution of resistance to QoI fungicides based on G143A is not likely to evolve in pathogens carrying an intron directly after this codon...
  43. ncbi Molecular phylogeny and taxonomy of wood mice (genus Apodemus Kaup, 1829) based on complete mtDNA cytochrome b sequences, with emphasis on Chinese species
    Xiaoming Liu
    Institute of Zoology, Chinese Academy of Sciences, Beijing 100080, China
    Mol Phylogenet Evol 33:1-15. 2004
    ..17-9.95 Mya. Four species of the Sylvaemus group were estimated to diverge at about 2.92-5.21 Mya. The Hengduan Mountains Region was hypothesized to have played important roles in Apodemus evolutionary histories since the Pleistocene...
  44. ncbi How Quaternary geologic and climatic events in the southeastern margin of the Tibetan Plateau influence the genetic structure of small mammals: inferences from phylogeography of two rodents, Neodon irene and Apodemus latronum
    Zhenxin Fan
    Sichuan Key Laboratory of Conservation Biology on Endangered Wildlife, College of Life Sciences, Sichuan University, Chengdu 610064, People s Republic of China
    Genetica 139:339-51. 2011
    ..Details of the historical demography of these rodents revealed in this study could provide new insights into how rodents and possibly other small mammals in this region responded to the geological and climatic events...
  45. ncbi Systematics and evolution of the subfamily Gerbillinae (Mammalia, Rodentia, Muridae)
    Pascale Chevret
    Institut des Sciences de l Evolution de Montpellier, Laboratoire de Paléontologie, Paléobiologie, Phylogénie, UMR CNRS 5554, Universite de Montpellier II, Place Emile Bataillon, 34095 Montpellier, France
    Mol Phylogenet Evol 35:674-88. 2005
    ..Finally, molecular datings for the various cladogenetic events are in good agreement with the known gerbilline fossil record and support an African origin with subsequent migrations to Asia...
  46. ncbi Preliminary genetic characterization of two lineages of black rats (Rattus rattus sensu lato) in Japan, with evidence for introgression at several localities
    Alejandro A Chinen
    Laboratory of Ecology and Genetics, Graduate School of Environmental Earth Science, Hokkaido University, Sapporo, Japan
    Genes Genet Syst 80:367-75. 2005
    ..Our results demonstrate the potential of combined analysis of karyotypes and mitochondrial and nuclear gene sequences to elucidate the complex dispersal and population history of the black rat...
  47. ncbi Dogs, cats, and kin: a molecular species-level phylogeny of Carnivora
    Ingi Agnarsson
    Biology Department, University of Puerto Rico Rio Piedras, San Juan, PR 00931, Puerto Rico
    Mol Phylogenet Evol 54:726-45. 2010
    ....
  48. ncbi Phylogeography of the mole-shrew (Anourosorex yamashinai) in Taiwan: implications of interglacial refugia in a high-elevation small mammal
    Shou Li Yuan
    Laboratory of Wildlife Ecology, Department of Life Science, Tunghai University, Taichung, Taiwan 407, ROC
    Mol Ecol 15:2119-30. 2006
    ..The present distribution pattern of haplotypes suggests that Mount Houhuan is an effective refugium in central Taiwan. It was not possible to specify the refugia for the Northern and Southern phylogroups...
  49. ncbi Phylogeny and temporal diversification of Calomys (Rodentia, Sigmodontinae): implications for the biogeography of an endemic genus of the open/dry biomes of South America
    Francisca C Almeida
    Institute for Comparative Genomics, American Museum of Natural History, New York, NY, USA
    Mol Phylogenet Evol 42:449-66. 2007
    ..This indicates the importance of safeguarding ecotones and the Cerrado at a time where this biome is being rapidly destroyed...
  50. pmc New insight into the colonization processes of common voles: inferences from molecular and fossil evidence
    Christelle Tougard
    UMR CNRS uB 5561 Biogéosciences Dijon, Universite de Bourgogne, Dijon, France
    PLoS ONE 3:e3532. 2008
    ..Multidisciplinary approaches should therefore be preferentially chosen in prospective studies, the better to understand the impact of climatic change on past and present biodiversity...
  51. ncbi Molecular phylogeny of Sinocyclocheilus (Cypriniformes: Cyprinidae) inferred from mitochondrial DNA sequences
    Heng Xiao
    Laboratory for Conservation and Utilization of Bio resource, Yunnan University, Kunming 650091, China
    Mol Phylogenet Evol 36:67-77. 2005
    ..hyalinus formed a strongly supported monophyletic group (clade V), probably reflecting their common origins. This result suggested that the diversification of Sinocyclocheilus in Yunnan may correlate with the uplifting of Yunnan Plateau...
  52. pmc Cryptic diversity and deep divergence in an upper Amazonian leaflitter frog, Eleutherodactylus ockendeni
    Kathryn R Elmer
    Department of Biology, Queen s University, Kingston, ON, K7L 3N6, Canada
    BMC Evol Biol 7:247. 2007
    ..Our extensive phylogeographic survey thus assesses the spatial distribution of E. ockendeni genetic diversity across eastern Ecuador...
  53. ncbi Phylogeny and distribution of crested gibbons (genus Nomascus) based on mitochondrial cytochrome b gene sequence data
    Van Ngoc Thinh
    Primate Genetics Laboratory, German Primate Center, Kellnerweg 4, Goettingen, Germany
    Am J Primatol 72:1047-54. 2010
    ..Our study shows that molecular methods are a useful tool to elucidate phylogenetic relationships among crested gibbons and to determine species boundaries...
  54. ncbi Phylogeography of surface and cave Astyanax (Teleostei) from Central and North America based on cytochrome b sequence data
    Ulrike Strecker
    Zoological Institute and Zoological Museum, University of Hamburg, Martin Luther King Platz 3, 20146 Hamburg, Germany
    Mol Phylogenet Evol 33:469-81. 2004
    ..fasciatus in Central and North America. Different haplotype clades of the phylogeny are not compatible with the present taxonomy of Astyanax and, therefore, we propose the application of a single systematic unit, called A. fasciatus...
  55. pmc Evidence of three maternal lineages in Near Eastern sheep supporting multiple domestication events
    Susana Pedrosa
    Department of Animal Production, University of Leon, 24071 Leon, Spain
    Proc Biol Sci 272:2211-7. 2005
    ..Finally, the evidence of a third maternal lineage has important implications regarding the history of modern sheep...
  56. ncbi Functional respiratory chain analyses in murid xenomitochondrial cybrids expose coevolutionary constraints of cytochrome b and nuclear subunits of complex III
    Matthew McKenzie
    Genomic Disorders Research Centre, University of Melbourne Department of Medicine, St Vincent s Hospital, Victoria, Australia
    Mol Biol Evol 20:1117-24. 2003
    ..The greater sensitivity of complex III to xenocybrid dysfunction may result from the encoding of redox center apoproteins in both nuclear and mitochondrial genomes, a unique feature of this RC complex...
  57. pmc Malarone treatment failure and in vitro confirmation of resistance of Plasmodium falciparum isolate from Lagos, Nigeria
    Quinton L Fivelman
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK
    Malar J 1:1. 2002
    ..The cytochrome b gene of isolate NGATV01 showed a single mutation, Tyr268Asn which has not been seen previously...
  58. ncbi Trans-Arctic dispersals and the evolution of a circumpolar marine fish species complex, the capelin (Mallotus villosus)
    Julian J Dodson
    Departement de Biologie, Pavillon Vachon, Universite Laval, Quebec, Canada G1K 7P4
    Mol Ecol 16:5030-43. 2007
    ..The Labrador Sea is a potential contact zone for three of the four capelin clades...
  59. ncbi The latitudinal gradient in recent speciation and extinction rates of birds and mammals
    Jason T Weir
    Biodiversity Research Center and Department of Zoology, University of British Columbia, Vancouver, BC V6T 1Z4, Canada
    Science 315:1574-6. 2007
    ..Instead, our findings suggest that faster turnover at high latitudes contributes to the latitudinal diversity gradient...
  60. ncbi Strong variations of mitochondrial mutation rate across mammals--the longevity hypothesis
    Benoit Nabholz
    Institut des Sciences de l Evolution CC64, Centre National de la Recherche Scientifique Université Montpellier 2, Montpellier, France
    Mol Biol Evol 25:120-30. 2008
    ..We propose that natural selection tends to decrease the mitochondrial mutation rate in long-lived species, in agreement with the mitochondrial theory of aging...
  61. pmc Uncovering the molecular mode of action of the antimalarial drug atovaquone using a bacterial system
    Michael W Mather
    Center for Molecular Parasitology, Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129, USA
    J Biol Chem 280:27458-65. 2005
    ..This mutation resulted in a 10-fold reduction in the in vitro activity of the cytochrome bc1 complex, suggesting that it may exert a cost on efficiency of the cytochrome bc1 complex...
  62. pmc Ecology of malaria parasites infecting Southeast Asian macaques: evidence from cytochrome b sequences
    Chaturong Putaporntip
    Molecular Biology of Malaria and Opportunistic Parasites Research Unit, Department of Parasitology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
    Mol Ecol 19:3466-76. 2010
    ..Parasite taxa differed with respect to both the frequency of between-host movement and their frequency of coinfection...
  63. ncbi Are cytochrome B gene sequencing and polymorphism-specific polymerase chain reaction as reliable as multilocus enzyme electrophoresis for identifying Leishmania spp. from Argentina?
    Jorge D Marco
    Department of Parasitology, Kochi Medical School, Kochi University, Kohasu, Kochi, Japan
    Am J Trop Med Hyg 75:256-60. 2006
    ..Thus, both techniques were validated and could be used independently for the species designation of Leishmania parasites in the country...
  64. pmc Phylogenetic relationships and biogeographical patterns in Circum-Mediterranean subfamily Leuciscinae (Teleostei, Cyprinidae) inferred from both mitochondrial and nuclear data
    Silvia Perea
    Museo Nacional de Ciencias Naturales CSIC, Department of Biodiversity and Evolutionary Biology, Jose Gutierrez Abascal 2, 28006 Madrid, Spain
    BMC Evol Biol 10:265. 2010
    ....
  65. pmc The erratic mitochondrial clock: variations of mutation rate, not population size, affect mtDNA diversity across birds and mammals
    Benoit Nabholz
    Université Montpellier 2 CNRS UMR 5554 Institut des Sciences de l Evolution Place E Bataillon CC064, Montpellier, France
    BMC Evol Biol 9:54. 2009
    ..These properties make birds the ideal model to directly test for population size effects, and to discriminate between competing hypotheses about the causes of substitution rate variation...
  66. ncbi Association between Helicobacter pylori-related peptic ulcer tissue and somatic mitochondrial DNA mutations
    Soong Lee
    Clin Chem 53:1390-2. 2007
  67. pmc Convergent, parallel and correlated evolution of trophic morphologies in the subfamily schizothoracinae from the Qinghai-Tibetan plateau
    Delin Qi
    Animal Science Department of Agriculture and Animal Husbandry College, Qinghai University, Xining, Qinghai, China
    PLoS ONE 7:e34070. 2012
    ....
  68. ncbi Molecular phylogeny and biogeography of Oriental voles: genus Eothenomys (Muridae, Mammalia)
    Jing Luo
    Laboratory of Molecular Biology of Domestic Animals, and Cellular and Molecular Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China
    Mol Phylogenet Evol 33:349-62. 2004
    ..6 million years, as well as to the effects of the mid-Quaternary ice age...
  69. ncbi Molecular phylogeny and biogeography of woolly flying squirrel (Rodentia: Sciuridae), inferred from mitochondrial cytochrome b gene sequences
    Fahong Yu
    Kunming Institute of Zoology, Kunming, Yunnan 650223, China
    Mol Phylogenet Evol 33:735-44. 2004
    ....
  70. ncbi Catalytically-relevant electron transfer between two hemes bL in the hybrid cytochrome bc1-like complex containing a fusion of Rhodobacter sphaeroides and capsulatus cytochromes b
    Monika Czapla
    Department of Molecular Biophysics, Biophysics and Biotechnology, Jagiellonian University, 30 387 Krakow, Poland
    Biochim Biophys Acta 1827:751-60. 2013
    ..One approach exploited a fusion of two cytochromes b that replaced the separate subunits in the dimer...
  71. ncbi Colonization process of the Brazilian common vesper mouse, Calomys expulsus (Cricetidae, Sigmodontinae): a biogeographic hypothesis
    Fabrícia Ferreira do Nascimento
    Genetics Division, Instituto Nacional de Cancer, Rua André Cavalcante 37, Rio de Janeiro, RJ, Brazil
    J Hered 102:260-8. 2011
    ....
  72. ncbi Phylogenetic analysis of snow sheep (Ovis nivicola) and closely related taxa
    T D Bunch
    Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, UT 84322, USA
    J Hered 97:21-30. 2006
    ..Cytogenetic analysis further validates that the standard diploid number for modern nivicola is 52...
  73. pmc The taxonomic status of the endangered thin-spined porcupine, Chaetomys subspinosus (Olfers, 1818), based on molecular and karyologic data
    Roberto V Vilela
    Departamento de Genética e Biologia Evolutiva, Instituto de Biociencias, Universidade de Sao Paulo, Rua do Matão 277, Cidade Universitaria, Sao Paulo, SP, Brazil
    BMC Evol Biol 9:29. 2009
    ..Our molecular analyses included one individual of Chaetomys subspinosus from the state of Bahia in northeastern Brazil, and other hystricognaths...
  74. ncbi Evolutionary history of the synbranchid eels (Teleostei: Synbranchidae) in Central America and the Caribbean islands inferred from their molecular phylogeny
    A Perdices
    Museo Nacional de Ciencias Naturales, CSIC, Jose Gutierrez Abascal 2, 28006 Madrid, Spain
    Mol Phylogenet Evol 37:460-73. 2005
    ..24 (1976) 431]. Instead, our phylogeographic results suggest that Ophisternon and Synbranchus mtDNA clades most likely colonized Central America during the Miocene (12.7-23Ma) prior the final closure of the Isthmus of Panama (3.3Ma)...
  75. ncbi Heterogeneous colonization pattern of European Cyprinids, as highlighted by the dace complex (Teleostei: Cyprinidae)
    C Costedoat
    EA 3781 EGEE Evolution Genome Environment Universite de Provence, Centre St Charles, Case 36, 3 Place Victor Hugo 13331 Marseille, France
    Mol Phylogenet Evol 41:127-48. 2006
    ..Finally, we demonstrated hybridization between L. leuciscus and Leuciscus idus...
  76. ncbi Phylogeography of a Sahelian rodent species Mastomys huberti: a Plio-Pleistocene story of emergence and colonization of humid habitats
    Karine Mouline
    IRD, Laboratoire de Mammalogie, Centre de Biologie et Gestion des Populations CBGP, BP 2528, Bamako, Mali
    Mol Ecol 17:1036-53. 2008
    ..More recently, M. huberti would have rapidly expanded into irrigated areas along the Senegal River and along the Canal du Sahel, Mali, reflecting the invasive and the pest character of this species...
  77. ncbi Study of the cytochrome b gene sequence in populations of Taiwan
    Hsiao Lin Hwa
    Department and Graduate Institute of Forensic Medicine, College of Medicine, National Taiwan University Hospital and National Taiwan University, No 7, Chung Shan South Road, Taipei 100, Taiwan
    J Forensic Sci 55:167-70. 2010
    ..In conclusion, there are sufficient sequence polymorphisms of the MTCYB gene in individuals of different populations, which may be used in the analyses of human ethnic groups in forensic casework...
  78. ncbi Origin and genetic diversity of Western European populations of the potato cyst nematode (Globodera pallida) inferred from mitochondrial sequences and microsatellite loci
    O Plantard
    INRA, UMR1099 BiO3P, F 35655 Le Rheu, France
    Mol Ecol 17:2208-18. 2008
    ..This finding has important consequences for the control of this pest and the development of quarantine measures...
  79. ncbi Disruption of a mitochondrial RNA-binding protein gene results in decreased cytochrome b expression and a marked reduction in ubiquinol-cytochrome c reductase activity in mouse heart mitochondria
    Fenghao Xu
    Programme in Genetics and Genome Biology, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada
    Biochem J 416:15-26. 2008
    ..This defines the site for PTCD2 action in mammalian mitochondria and suggests a possible role for dysfunction of this protein in the aetiology of heart failure...
  80. ncbi Cytochrome b gene sequence and structure of Pyrenophora teres and P. tritici-repentis and implications for QoI resistance
    Helge Sierotzki
    Syngenta Crop Protection, Research Biology, 4332 Stein, Switzerland
    Pest Manag Sci 63:225-33. 2007
    ..No G143A isolates were found in any P. teres populations. Although different mutations may evolve in P. tritici-repentis, the G143A mutation will have the strongest impact on field performance of QoI fungicides...
  81. ncbi An intron in the cytochrome b gene of Monilinia fructicola mitigates the risk of resistance development to QoI fungicides
    Chao Xi Luo
    Department of Plant Pathology, College of Plant Science and Technology and the Key Lab of Crop Disease Monitoring and Safety Control in Hubei Province, Huazhong Agricultural University, Wuhan, PR China
    Pest Manag Sci 66:1308-15. 2010
    ..The objective of this study was to clone and sequence the Cyt b gene from Monilinia fructicola (Wint.) Honey, the causal agent of brown rot of stone fruits, and to assess the risk for the development of a mutation at position 143...
  82. ncbi Prevalence of avian malaria parasite in mosquitoes collected at a zoological garden in Japan
    Hiroko Ejiri
    Laboratory of Biomedical Science, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, Fujisawa, 252 8510, Japan
    Parasitol Res 105:629-33. 2009
    ..Our results suggest that C. pipiens group and L. vorax could be incriminated vectors of avian malaria parasite transmitting in captive birds kept in the zoological garden in Japan...
  83. ncbi QO site deficiency can be compensated by extragenic mutations in the hinge region of the iron-sulfur protein in the bc1 complex of Saccharomyces cerevisiae
    Gael Brasseur
    Laboratoire de Bioenergetique et Ingenierie des Proteines, CNRS, 31 Chemin Joseph Aiguier, 13402 Marseille Cedex 20, France
    J Biol Chem 279:24203-11. 2004
    ....
  84. ncbi Comparative phylogeography of two sibling species of forest-dwelling rodent (Praomys rostratus and P. tullbergi) in West Africa: different reactions to past forest fragmentation
    V Nicolas
    Museum national d histoire naturelle, Département de Systématique et Evolution, UMR 5202, Laboratoire Mammifères et Oiseaux, 57 rue Cuvier, CP 51, 75005 Paris, France
    Mol Ecol 17:5118-34. 2008
    ..In addition, historical variations of the West African hydrographic network could also have contributed to the pattern of genetic differentiation observed in both species...
  85. ncbi Entomological study on transmission of avian malaria parasites in a zoological garden in Japan: bloodmeal identification and detection of avian malaria parasite DNA from blood-fed mosquitoes
    Hiroko Ejiri
    Laboratory of Biomedical Science, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, Kameino 1866, Fujisawa, Kanagawa, Japan
    J Med Entomol 48:600-7. 2011
    ....
  86. pmc Coquillettidia (Culicidae, Diptera) mosquitoes are natural vectors of avian malaria in Africa
    Kevin Y Njabo
    Center for Tropical Research, UCLA Institute of the Environment, Los Angeles, California, USA
    Malar J 8:193. 2009
    ..The mosquito vectors of Plasmodium spp. have largely been overlooked in studies of ecology and evolution of avian malaria and other vertebrates in wildlife...
  87. ncbi The phylogeny of Cetartiodactyla: the importance of dense taxon sampling, missing data, and the remarkable promise of cytochrome b to provide reliable species-level phylogenies
    Ingi Agnarsson
    Department of Biology, University of Akron, Akron, OH 44325 3908, USA
    Mol Phylogenet Evol 48:964-85. 2008
    ..Therefore, an opportunity exists now to reconstruct detailed phylogenies of most of the major mammalian clades to rapidly provide much needed tools for species-level comparative studies...
  88. ncbi Coamplification of Leucocytozoon by PCR diagnostic tests for avian malaria: a cautionary note
    C L Cosgrove
    Edward Grey Institute, Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK
    J Parasitol 92:1362-5. 2006
    ..We, therefore, advocate the use of a post-PCR diagnostic step, such as RFLP analysis or sequencing, to assess the contribution of Leucocytozoon spp. to overall prevalence...
  89. ncbi Molecular systematics and origin of sociality in mongooses (Herpestidae, Carnivora)
    Geraldine Veron
    Unité Origine, Structure et Evolution de la Biodiversité, CNRS MNHN, Departement Systematique et Evolution, Museum national d histoire naturelle, 55, rue Buffon, 75005 Paris, France
    Mol Phylogenet Evol 30:582-98. 2004
    ..The mapping of ecological and behavioural features resulted in hypothesizing solitary behavior and life in forest as the conditions at the base of the mongoose clade...
  90. ncbi Mitochondrial cytochrome b sequence variation and phylogenetics of the highly specialized Schizothoracine fishes (Teleostei: Cyprinidae) in the Qinghai-Tibet plateau
    Delin Qi
    Northwest Plateau Institute of Biology, Chinese Academy of Science, Xining, 810001, PR China
    Biochem Genet 44:270-85. 2006
    ..5 x 10(4)-4.05 x 10(6 ) years BP). The relationship between the cladogenesis of highly specialized schizothoracine fishes and geographical events of the Qinghai-Tibet plateau is discussed...
  91. pmc The small subunit AroB of arsenite oxidase: lessons on the [2Fe-2S] Rieske protein superfamily
    Simon Duval
    Laboratoire de Bioénergétique et Ingénierie des Protéines UPR 9036, Institut de Biologie Structurale et Microbiologie, CNRS, F 13402 Marseille Cedex 20, France
    J Biol Chem 285:20442-51. 2010
    ..However, two cysteine residues, strictly conserved in the Rieske-cyt b-Rieske and considered to be crucial for its function, are not conserved in the arsenite oxidase counterpart. We discuss the role of these residues...
  92. ncbi The "green" phylogenetic clade of Rieske/cytb complexes
    W Nitschke
    BIP, Centre National de la Recherche Scientifique, UPR9036, IFR88, 31 Chemin Joseph Aiguier, Marseille, France
    Photosynth Res 104:347-55. 2010
    ..Structural and functional idiosyncrasies are (re-)interpreted in the framework of evolutionary biology and more specifically evolutionary bioenergetics...
  93. ncbi A molecular clock for malaria parasites
    Robert E Ricklefs
    Department of Biology, University of Missouri St Louis, One University Boulevard, St Louis, MO 63121 4499, USA
    Science 329:226-9. 2010
    ..falciparum at 2.5 million years ago (Ma), the initial radiation of mammalian Plasmodium at 12.8 Ma, and the contemporary global diversity of the Haemosporida across terrestrial vertebrates at 16.2 Ma...
  94. ncbi The Rieske/cytochrome b complex of Heliobacteria
    A L Ducluzeau
    Laboratoire de Bioenergetique et Ingenierie des Proteines, Institut de Biologie Structurale et Microbiologie, Unité Propre de Recherche 9036, Centre National de la Recherche Scientifique, 31, Chemin Joseph Aiguier, 13402 Marseille Cedex 20, France
    Biochim Biophys Acta 1777:1140-6. 2008
    ..In contrast to the case of b(6)f complex, a strong axial ligand to the heme is present, most probably a protonatable amino acid residue...
  95. pmc Monilinia species causing brown rot of peach in China
    Meng Jun Hu
    Department of Plant Pathology, College of Plant Science and Technology and the Key Lab of Crop Disease Monitoring and Safety Control in Hubei Province, Huazhong Agricultural University, Wuhan, People s Republic of China
    PLoS ONE 6:e24990. 2011
    ..yunnanensis as a new species. A new multiplex PCR method was developed to facilitate the detection of M. yunnanensis and differentiation of Monilinia spp. causing brown rot of peach in China...
  96. pmc Fusing two cytochromes b of Rhodobacter capsulatus cytochrome bc1 using various linkers defines a set of protein templates for asymmetric mutagenesis
    Monika Czapla
    Department of Molecular Biophysics, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, 30 387 Krakow, Poland
    Protein Eng Des Sel 25:15-25. 2012
    ..We show that two cytochromes b can be fused into one 16-helical subunit using a number of different peptide linkers that vary in length but ..
  97. ncbi Linkage between mitochondrial cytochrome b lineages and morphospecies of two avian malaria parasites, with a description of Plasmodium (Novyella) ashfordi sp. nov
    Gediminas Valkiunas
    Institute of Ecology, Vilnius University, Akademijos 2, Vilnius 21, LT 08412, Lithuania
    Parasitol Res 100:1311-22. 2007
    ..Other lineages closely related to P. ashfordi and P. relictum are identified. This study establishes the value of PCR-based identification of avian malaria parasites...
  98. ncbi Molecular evidence for the polyphyly of the genus Hemitragus (Mammalia, Bovidae)
    Anne Ropiquet
    UMR 5202 Origine, Structure et Evolution de la Biodiversité, Departement Systematique et Evolution, Museum national d histoire naturelle, Case postale No 51, 55 rue Buffon, 75005 Paris, France
    Mol Phylogenet Evol 36:154-68. 2005
    ....
  99. ncbi Identification and characterization of a new gene (CBP3) required for the expression of yeast coenzyme QH2-cytochrome c reductase
    M Wu
    Department of Biological Sciences, Columbia University, New York, New York 10027
    J Biol Chem 264:11122-30. 1989
    ..The CBP3 protein is a membrane constituent, although attempts to demonstrate its physical association with the other subunits of coenzyme QH2-cytochrome c reductase have been unsuccessful...
  100. ncbi Mitochondrial phylogeny of African wood mice, genus Hylomyscus (Rodentia, Muridae): implications for their taxonomy and biogeography
    V Nicolas
    MNHN, Département de Systématique et Evolution, UMR 5202, Laboratoire Mammifères et Oiseaux, 55 rue Buffon, 75005 Paris, France
    Mol Phylogenet Evol 38:779-93. 2006
    ..Future reports should focus on the geographic distribution of Hylomyscus species in order to get a better understanding of the evolutionary history of the genus...
  101. ncbi Physicochemical evolution and molecular adaptation of the cetacean and artiodactyl cytochrome b proteins
    D A McClellan
    Department of Integrative Biology, Brigham Young University, Provo, Utah, USA
    Mol Biol Evol 22:437-55. 2005
    ..We also have found a general correlation between the results of the analytical software programs TreeSAAP (which implements the MM01 model) and CDM (which implements the codon-degeneracy model)...

Research Grants21

  1. Protein-Facilitated Group I Intron Splicing
    Mark Caprara; Fiscal Year: 2006
    ..A co-crystal of IAniI and its DNA target site diffracts to high resolution and the resulting structure will provide a powerful reference to establish structure-function relationships. ..
  2. CYTOCHROME B5--A CASE STUDY IN MOLECULAR RECOGNITION
    Mario Rivera; Fiscal Year: 1999
    b>Cytochromes b are an important class of hemoproteins involved in electron transfer reactions...
  3. ENERGY CONSERVATION AND TRANSFER IN MITOCHONDRIA
    Youssef Hatefi; Fiscal Year: 2001
    ..of two groups do not show Q in this region, and (c) the extrinsic domain of ISP appears to swing between cytochromes b and c1...
  4. MITOCHONDRIAL GENES OF PLASMODIUM FALCIPARUM
    JEAN FEAGIN; Fiscal Year: 1992
    ..falciparum. In addition, the antimalarial action of many compounds which affect mitochondrial function suggests that these studies may provide insights into new chemotherapeutic approaches to the treatment of malaria...
  5. STUDY OF THE C REINHARDTII MITOCHONDRIAL GENOME
    Din Pow Ma; Fiscal Year: 1991
    ..Their possible involvement in replication, transcription, and recombination will also be investigated...
  6. EVOLUTION OF IMMUNE RECOGNITION AND EVASION
    Austin L Hughes; Fiscal Year: 2010
    ..In addition, by increasing our understanding of the population diversity and evolutionary history of human immune system genes, this research will enhance our knowledge of human immune function in health and disease. ..
  7. HTS For Inhibitors of NADPH Oxidase 1 (Nox1)
    Gary Bokoch; Fiscal Year: 2008
    ..Such inhibitors will be useful to investigate Nox1 biology, and as potential therapeutic agents in inflammatory diseases and cancer. [unreadable] [unreadable] [unreadable]..
  8. Mechanisms of HIF activation in pulmonary vasculature.
    Navdeep Chandel; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  9. Trypansome RNA Editing in Two Developmental Forms
    Jorge Cruz Reyes; Fiscal Year: 2008
    ..Together these studies should provide important insights into the developmental control of RNA editing, and understanding of relevant RNA/protein interactions during this unique maturation process. [unreadable] [unreadable]..
  10. REGULATION OF NEUTROPHIL RECEPTOR G PROTEIN INTERACTIONS
    Gary Bokoch; Fiscal Year: 2009
    ..Spatio-temporal evaluation of Rho activation will be related to Rac2 activity, as well as specific aspects of a) chemoattractant receptor signaling, b) motile behavior, and c) actin-myosin cytoskeletal dynamics. ..
  11. Mechanisms of Replicative Senescence of lung cells during hypoxia.
    Navdeep Chandel; Fiscal Year: 2007
    ..Collectively these studies will provide new information regarding mechanisms underlying replicative senescence and the aging process. [unreadable] [unreadable] [unreadable]..
  12. SCienceLab
    Bert Ely; Fiscal Year: 2010
    ..To address this problem, SCienceLab provides an opportunity for students to spend a day experiencing research and interacting with students who are working in a biomedical research laboratory. ..
  13. HOST IMMUNOREGULATION OF ANTILEISHMANIAL CHEMOTHERAPY
    Henry Murray; Fiscal Year: 2005
    ..And Aim 3: Characterize immunostimulation in AmB's efficacy, and in recrudescent infection following AmB therapy, pinpoint the likely cytokine-driven T cell mechanism which prevents post-treatment relapse. ..
  14. CONTROL OF PHAGOCYTE NADPH OXIDASE BY CYTOSOLIC PROTEINS
    Gary Bokoch; Fiscal Year: 2005
    ....
  15. Protein Radical, Protein Nitration, Mitochondria, and AD
    Yeong Renn Chen; Fiscal Year: 2004
    ..The results will provide fundamental information concerning the pathological relevance of neurodegenerative disease, such as AD, associated with mitochondrial dysfunction caused by oxidative damage. ..
  16. Host Immunoregulation of Response to Antileishmanial Chemotherapy
    Henry Murray; Fiscal Year: 2007
    ..abstract_text> ..
  17. The Role of Mitochondrial DNA Alterations in Cancer
    Lee Jun Wong; Fiscal Year: 2008
    ..Results from this research project will help us understand the functional role of mitochondrial DNA alterations in cancer and identify potential novel targets for more effective therapeutic development. ..
  18. Gene Duplication and Genome Evolution
    Austin Hughes; Fiscal Year: 2004
    ..5) Examining the role of transposable elements in duplication of genomic segments by testing for nonrandom association between these elements and putatively duplicated blocks in the yeast genome. ..
  19. S. aureus SarU and Rot regulate virulence factor genes
    Peter McNamara; Fiscal Year: 2004
    ..Aim 2. To characterize mechanism(s) of SarU activation of a-toxin production by demonstrating direct and temporally appropriate interactions between SarU and its target genes. ..