cytochrome p 450 cyp1a1

Summary

Summary: A liver microsomal cytochrome P-450 monooxygenase capable of biotransforming xenobiotics such as polycyclic hydrocarbons and halogenated aromatic hydrocarbons into carcinogenic or mutagenic compounds. They have been found in mammals and fish. This enzyme, encoded by CYP1A1 gene, can be measured by using ethoxyresorufin as a substrate for the ethoxyresorufin O-deethylase activity.

Top Publications

  1. ncbi Functional role of AhR in the expression of toxic effects by TCDD
    Junsei Mimura
    Department of Biomolecular Science, Graduate School of Life Science, Tohoku University, Aoba ku, 980 8578, Sendai, Japan
    Biochim Biophys Acta 1619:263-8. 2003
  2. ncbi Resveratrol, a natural aryl hydrocarbon receptor antagonist, protects lung from DNA damage and apoptosis caused by benzo[a]pyrene
    Ariel Revel
    Division of Reproductive Sciences, Department of Obstetrics and Gynecology, University of Toronto, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 21X5, Canada
    J Appl Toxicol 23:255-61. 2003
  3. ncbi Novel compound 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazo-phenyl)-amide (CH-223191) prevents 2,3,7,8-TCDD-induced toxicity by antagonizing the aryl hydrocarbon receptor
    Sun Hee Kim
    School of Environmental Science and Engineering, Pohang University of Science and Technology, Pohang 790 784, South Korea
    Mol Pharmacol 69:1871-8. 2006
  4. pmc Antiproliferative and cytostatic effects of the natural product eupatorin on MDA-MB-468 human breast cancer cells due to CYP1-mediated metabolism
    Vasilis Androutsopoulos
    Leicester School of Pharmacy, De Montfort University, The Gateway, Leicester, UK
    Breast Cancer Res 10:R39. 2008
  5. pmc Aryl hydrocarbon receptor-mediated transcription: ligand-dependent recruitment of estrogen receptor alpha to 2,3,7,8-tetrachlorodibenzo-p-dioxin-responsive promoters
    Jason Matthews
    Department of Biosciences at Novum, Karolinska Institutet, Novum 14157, Sweden
    Mol Cell Biol 25:5317-28. 2005
  6. ncbi Identification of the tryptophan photoproduct 6-formylindolo[3,2-b]carbazole, in cell culture medium, as a factor that controls the background aryl hydrocarbon receptor activity
    Mattias Oberg
    Institute of Environmental Medicine, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Toxicol Sci 85:935-43. 2005
  7. ncbi Aryl hydrocarbon receptor expression and activity in cerebellar granule neuroblasts: implications for development and dioxin neurotoxicity
    Mary A Williamson
    Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Toxicol Sci 83:340-8. 2005
  8. ncbi Phase I and II carcinogen metabolism gene expression in human lung tissue and tumors
    Simon D Spivack
    Wadsworth Center, New York State Department of Health, Albany, New York, USA
    Clin Cancer Res 9:6002-11. 2003
  9. ncbi Low-dose dioxins alter gene expression related to cholesterol biosynthesis, lipogenesis, and glucose metabolism through the aryl hydrocarbon receptor-mediated pathway in mouse liver
    Shoko Sato
    Laboratory of Nutrition, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan
    Toxicol Appl Pharmacol 229:10-9. 2008
  10. ncbi Correlation of cardiotoxicity mediated by halogenated aromatic hydrocarbons to aryl hydrocarbon receptor activation
    S E Heid
    Department of Pharmacology, University of Kentucky Medical Center, Lexington, Kentucky 40536, USA
    Toxicol Sci 61:187-96. 2001

Research Grants

  1. CYP1A1 GENOTYPE & INDUCIBIL PHENOTYPE-HUM LUNG CA RISK
    Jennifer Hu; Fiscal Year: 1992
  2. BREAST CANCER RISK--RESIDENTIAL ENVIRONMENT AND GENETICS
    Jo Freudenheim; Fiscal Year: 2001
  3. GENE MUTATIONS IN ESTROGEN-INDUCED CARCINOGENESIS
    JOACHIM LIEHR; Fiscal Year: 1999
  4. MINORITY PREDOCTORAL FELLOWSHIP PROGRAM
    DEANNA WORMLEY; Fiscal Year: 2002
  5. RECEPTOR MEDIATED OXIDATIVE STRESS
    HOWARD SHERTZER; Fiscal Year: 2003
  6. Carcinogenicity of Estrogens
    DAVID SPINK; Fiscal Year: 2009
  7. Glutathione in Environmental Toxicity and Disease
    HOWARD SHERTZER; Fiscal Year: 2007
  8. CYP1A1 GENE AND ENVIRONMENTAL TOXICITY
    Daniel Nebert; Fiscal Year: 2005
  9. PAHs: Balance of Detoxication vs Metabolic Activation
    Daniel Nebert; Fiscal Year: 2009
  10. Molecular Genetics of Cadmium Toxicity
    Daniel W Nebert; Fiscal Year: 2010

Detail Information

Publications286 found, 100 shown here

  1. ncbi Functional role of AhR in the expression of toxic effects by TCDD
    Junsei Mimura
    Department of Biomolecular Science, Graduate School of Life Science, Tohoku University, Aoba ku, 980 8578, Sendai, Japan
    Biochim Biophys Acta 1619:263-8. 2003
    ..We summarize the present knowledge about functional role of AhR in TCDD-induced biological effects...
  2. ncbi Resveratrol, a natural aryl hydrocarbon receptor antagonist, protects lung from DNA damage and apoptosis caused by benzo[a]pyrene
    Ariel Revel
    Division of Reproductive Sciences, Department of Obstetrics and Gynecology, University of Toronto, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 21X5, Canada
    J Appl Toxicol 23:255-61. 2003
    ..All BaP-induced effects could be prevented by resveratrol, suggesting a possible chemopreventive role for this natural phytoalexin against the development of lung cancer...
  3. ncbi Novel compound 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazo-phenyl)-amide (CH-223191) prevents 2,3,7,8-TCDD-induced toxicity by antagonizing the aryl hydrocarbon receptor
    Sun Hee Kim
    School of Environmental Science and Engineering, Pohang University of Science and Technology, Pohang 790 784, South Korea
    Mol Pharmacol 69:1871-8. 2006
    ..Taken together, these results demonstrate that this novel compound, CH-223191, may be a useful agent for the study of AhR-mediated signal transduction and the prevention of TCDD-associated pathology...
  4. pmc Antiproliferative and cytostatic effects of the natural product eupatorin on MDA-MB-468 human breast cancer cells due to CYP1-mediated metabolism
    Vasilis Androutsopoulos
    Leicester School of Pharmacy, De Montfort University, The Gateway, Leicester, UK
    Breast Cancer Res 10:R39. 2008
    ..In this study, we aimed to identify a possible mechanism of action for the antiproliferative effect of eupatorin, which can be attributed to CYP1 family-mediated metabolism...
  5. pmc Aryl hydrocarbon receptor-mediated transcription: ligand-dependent recruitment of estrogen receptor alpha to 2,3,7,8-tetrachlorodibenzo-p-dioxin-responsive promoters
    Jason Matthews
    Department of Biosciences at Novum, Karolinska Institutet, Novum 14157, Sweden
    Mol Cell Biol 25:5317-28. 2005
    ..Our data suggest that ERalpha acts as a coregulator of AhR-mediated transcriptional activation and that the recruitment of ERalpha by AhR represents a novel mechanism AhR-ERalpha cross talk...
  6. ncbi Identification of the tryptophan photoproduct 6-formylindolo[3,2-b]carbazole, in cell culture medium, as a factor that controls the background aryl hydrocarbon receptor activity
    Mattias Oberg
    Institute of Environmental Medicine, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Toxicol Sci 85:935-43. 2005
    ..These results clearly show that tryptophan derived AhR ligands, which have been suggested to be endogenous AhR ligands, influence the background levels of CYP1A1 activity in cells in culture...
  7. ncbi Aryl hydrocarbon receptor expression and activity in cerebellar granule neuroblasts: implications for development and dioxin neurotoxicity
    Mary A Williamson
    Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Toxicol Sci 83:340-8. 2005
    ..These data suggest that (1) granule neuroblasts are direct targets for developmental AhR-mediated TCDD neurotoxicity and (2) TCDD exposure may disrupt granule cell neurogenesis...
  8. ncbi Phase I and II carcinogen metabolism gene expression in human lung tissue and tumors
    Simon D Spivack
    Wadsworth Center, New York State Department of Health, Albany, New York, USA
    Clin Cancer Res 9:6002-11. 2003
    ....
  9. ncbi Low-dose dioxins alter gene expression related to cholesterol biosynthesis, lipogenesis, and glucose metabolism through the aryl hydrocarbon receptor-mediated pathway in mouse liver
    Shoko Sato
    Laboratory of Nutrition, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan
    Toxicol Appl Pharmacol 229:10-9. 2008
    ..These results indicate that changes in gene expression by TCDD are mediated by AHR and that exposure to low-dose TCDD could affect energy metabolism via alterations of gene expression...
  10. ncbi Correlation of cardiotoxicity mediated by halogenated aromatic hydrocarbons to aryl hydrocarbon receptor activation
    S E Heid
    Department of Pharmacology, University of Kentucky Medical Center, Lexington, Kentucky 40536, USA
    Toxicol Sci 61:187-96. 2001
    ..These results indicate that the ability of HAHs to activate the avian AHR signaling pathway, in general, correlates with their ability to mediate cardiotoxicity in the chick embryo...
  11. ncbi Overexpression of cytochrome P450 1A1 and its novel spliced variant in ovarian cancer cells: alternative subcellular enzyme compartmentation may contribute to carcinogenesis
    Yuet Kin Leung
    Department of Surgery, University of Massachusetts Medical School, Worcester, Massachusetts 01605 2324, USA
    Cancer Res 65:3726-34. 2005
    ..Collectively, these data provided the first evidence that CYP1A1 overexpression and alternative splicing could contribute to ovarian cancer initiation and progression...
  12. ncbi Resveratrol is a selective human cytochrome P450 1A1 inhibitor
    Y J Chun
    College of Pharmacy, Chungang University, Seoul, Korea, 156 756
    Biochem Biophys Res Commun 262:20-4. 1999
    ..These results suggest that resveratrol is a selective human P450 1A1 inhibitor, and may be considered for use as a strong cancer chemopreventive agent in humans...
  13. ncbi Polymorphisms of the CYP1A1 and GSTM1 gene involved in oral squamous cell carcinoma in association with a cigarette dose
    K Tanimoto
    Department of Oral and Maxillofacial Surgery I, Hiroshima University School of Dentistry, Japan
    Oral Oncol 35:191-6. 1999
    ..The results also suggested that the involvement of such susceptibility in oral carcinogenesis might be different between the subsites of the oral cavity...
  14. ncbi Relationship between genetic polymorphisms of drug-metabolizing enzymes (CYP1A1, CYP2E1, GSTM1, and NAT2), drinking habits, histological subtypes, and p53 gene point mutations in Japanese patients with gastric cancer
    Shioto Suzuki
    Department of Molecular and Cellular Pathology, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan
    J Gastroenterol 39:220-30. 2004
    ..Therefore, we studied the relationship between the genetic polymorphisms of drug-metabolizing enzymes, drinking habits, histological subtypes, and p53 gene point mutations in Japanese patients with gastric cancer...
  15. pmc Multifactor-dimensionality reduction reveals high-order interactions among estrogen-metabolism genes in sporadic breast cancer
    M D Ritchie
    Program in Human Genetics, Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, TN 37232, USA
    Am J Hum Genet 69:138-47. 2001
    ..To our knowledge, this is the first report of a four-locus interaction associated with a common complex multifactorial disease...
  16. ncbi Resveratrol inhibits TCDD-induced expression of CYP1A1 and CYP1B1 and catechol estrogen-mediated oxidative DNA damage in cultured human mammary epithelial cells
    Zhi Hua Chen
    College of Pharmacy, Seoul National University, Seoul 151 742, South Korea
    Carcinogenesis 25:2005-13. 2004
    ....
  17. pmc Expression of CYP1A1 and CYP1B1 in human endothelial cells: regulation by fluid shear stress
    Daniel E Conway
    Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology Emory University School of Medicine, 313 Ferst Drive, Suite 2116, Atlanta, GA 30332 0535, USA
    Cardiovasc Res 81:669-77. 2009
    ....
  18. ncbi Role of aryl hydrocarbon receptor-mediated induction of the CYP1 enzymes in environmental toxicity and cancer
    Daniel W Nebert
    Department of Environmental Health and Center for Environmental Genetics, University of Cincinnati Medical Center, Cincinnati, Ohio 45267 0056, USA
    J Biol Chem 279:23847-50. 2004
    ..In the future, use of "humanized" mouse lines, containing a human AHR or CYP1 allele in place of the orthologous mouse gene, is one likely approach to show that the AHR and the CYP1 enzymes in human behave similarly to that in mouse...
  19. ncbi CYP1A1, cigarette smoking, and colon and rectal cancer
    Martha L Slattery
    Health Research Center, University of Utah Health Sciences Center, Salt Lake City, UT 84108, USA
    Am J Epidemiol 160:842-52. 2004
    ..These data support the association between smoking and colon and rectal cancer. Smoking may have a greater impact on colorectal cancer risk based on CYP1A1 genotype; this might further be modified by GSTM1 for rectal cancer risk...
  20. ncbi Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals
    Michael S Denison
    Department of Environmental Toxicology, University of California, Davis, California 95616, USA
    Annu Rev Pharmacol Toxicol 43:309-34. 2003
    ....
  21. ncbi Metabolic activation of polycyclic aromatic hydrocarbons to carcinogens by cytochromes P450 1A1 and 1B1
    Tsutomu Shimada
    Osaka Prefectural Institute of Public Health, Higashinari ku, Osaka 537 0025, Japan
    Cancer Sci 95:1-6. 2004
    ..Differences in the susceptibility of individuals to the adverse action of PAHs may, in part, be due to differences in the levels of expression of CYP1A1 and 1B1 and to genetic variations in the CYP1A1 and 1B1 genes...
  22. pmc Combinations of cytochrome P-450 genotypes and risk of early-onset lung cancer in Caucasians and African Americans: a population-based study
    M L Cote
    Population Studies and Prevention Program, Karmanos Cancer Institute at Wayne State University School of Medicine, Detroit, MI, United States
    Lung Cancer 55:255-62. 2007
    ..41 95% Cl 0.19-0.90). These results were not replicated among the African American population, nor were they modified by amount of smoking...
  23. ncbi Evidence for an aryl hydrocarbon receptor-mediated cytochrome p450 autoregulatory pathway
    Christopher R Chiaro
    Graduate Program in Genetics The Pennsylvania State University, University Park, PA 16802, USA
    Mol Pharmacol 72:1369-79. 2007
    ..These results suggest that there is an autoregulatory feedback loop between the AhR and cytochrome P450 1A1 in mouse lung...
  24. ncbi Interactive effects of superoxide anion and nitric oxide on blood pressure and renal hemodynamics in transgenic rats with inducible malignant hypertension
    Matthew E Patterson
    Dept of Physiology, Tulane Univ Health Sciences Center, 1430 Tulane Ave, SL39, New Orleans, LA 70112, USA
    Am J Physiol Renal Physiol 289:F754-9. 2005
    ..These findings indicate that superoxide anion contributes to the elevated RVR and increased arterial blood pressure, by a mechanism that is at least in part nitric oxide dependent, in Cyp1a1-Ren2 rats with malignant hypertension...
  25. ncbi Endothelial cell cytochrome P450 1A1 and 1B1: up-regulation by shear stress
    Suzanne G Eskin
    Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia 30309, USA
    Endothelium 11:1-10. 2004
    ..Protein levels of CYP1A1 in HUVECs were up-regulated under shear stress, whereas protein levels of CYP1B1 were not...
  26. ncbi Anticancer effects of the flavonoid diosmetin on cell cycle progression and proliferation of MDA-MB 468 breast cancer cells due to CYP1 activation
    Vasilis P Androutsopoulos
    Leicester School of Pharmacy, De Montfort University, The Gateway, Leicester, LE1 9BH, UK
    Oncol Rep 21:1525-8. 2009
    ..We suggest that diosmetin exerts cytostatic effects in MDA-MB 468 cells, due to CYP1A1 and CYP1B1 catalyzed conversion to the flavone luteolin...
  27. ncbi Association between xenobiotic gene polymorphisms and non-Hodgkin's lymphoma risk
    Ian Kerridge
    Hunter Haematology Research Group, Newcastle Mater Hospital, Newcastle, Australia
    Br J Haematol 118:477-81. 2002
    ....
  28. ncbi Genetically high susceptibility to oral squamous cell carcinoma in terms of combined genotyping of CYP1A1 and GSTM1 genes
    M Sato
    Maxillofacial Surgery, Graduate School, Tokyo Medical and Dental University, 5 45, Yushima 1 chome, Bunkyo ku, Tokyo, Japan
    Oral Oncol 36:267-71. 2000
    ..Individuals with a combined genotype of Val/Val and GSTM1(-) were at an increased risk for oral SCC compared with other combined genotypes, in particular, at a low dose level of cigarette smoking...
  29. ncbi Induction of cytochrome P4501A1
    J P Whitlock
    Department of Molecular Pharmacology, Stanford University School of Medicine, California 94305 5332, USA
    Annu Rev Pharmacol Toxicol 39:103-25. 1999
    ....
  30. ncbi Dietary accumulation and biochemical responses of juvenile rainbow trout (Oncorhynchus mykiss) to 3,3',4,4',5-pentachlorobiphenyl (PCB 126)
    Scott B Brown
    Environment Canada, National Water Research Institute, 867 Lakeshore Blvd, PO Box 5050, Ont, L7R 4A6, Burlington, Canada
    Aquat Toxicol 59:139-52. 2002
    ..This indicates that the functional competences of the physiological factors associated with growth were maintained under the experimental conditions...
  31. ncbi Involvement of a post-transcriptional mechanism in the inhibition of CYP1A1 expression by resveratrol in breast cancer cells
    J E Lee
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, 4466 TAMU, College Station, TX 77843-4466, USA
    Biochem Pharmacol 62:1113-24. 2001
    ..These data suggest that resveratrol inhibits CYP1A1 via an AhR-independent post-transcriptional pathway...
  32. ncbi Altered thyroxin and retinoid metabolic response to 2,3,7,8-tetrachlorodibenzo-p-dioxin in aryl hydrocarbon receptor-null mice
    Noriko Nishimura
    Endocrine Disruptors and Dioxin Research Project, National Institute for Environmental Studies, 305 8506 Tsukuba, Japan
    Arch Toxicol 79:260-7. 2005
    ..We conclude that disruption of thyroid hormone and retinoid homeostasis is mediated entirely via AhR. Induction of UGT1A6 is thought to be responsible at least partly for reduced serum thyroid hormone levels in TCDD-exposed mice...
  33. ncbi Nucleocytoplasmic shuttling of the aryl hydrocarbon receptor
    T Ikuta
    Saitama Cancer Center Research Institute, Komuro, Ina machi, Kitaadachi gun, Saitama 362 0806, Japan
    J Biochem 127:503-9. 2000
    ..The findings suggest that nuclear-cytoplasmic shuttling of AhR is essential for the inducible expression of the CYP1A1 protein...
  34. ncbi Analysis of aryl hydrocarbon receptor-mediated signaling during physiological hypoxia reveals lack of competition for the aryl hydrocarbon nuclear translocator transcription factor
    R S Pollenz
    Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina 29403, USA
    Mol Pharmacol 56:1127-37. 1999
    ....
  35. ncbi Cytochrome P4501A (CYP1A) in killifish (Fundulus heteroclitus): heritability of altered expression and relationship to survival in contaminated sediments
    Joel N Meyer
    Nicholas School of the Environment and Earth Sciences and Integrated Toxicology Program, Duke University, Durham, North Carolina 27708 0328, USA
    Toxicol Sci 68:69-81. 2002
    ..Additionally, we investigated the hypothesis that low CYP1A activity (measured as in ovo EROD activity) would correlate to increased survival in Elizabeth River sediment pore water; this hypothesis was not supported by our results...
  36. ncbi Determination of cytochrome P450 1A activities in mammalian liver microsomes by high-performance liquid chromatography with fluorescence detection
    N Hanioka
    Division of Environmental Chemistry, National Institute of Health Sciences, Tokyo, Japan
    J Chromatogr B Biomed Sci Appl 744:399-406. 2000
    ..Therefore, this method is applicable to in vivo and in vitro studies on the interaction of xenobiotic chemicals with cytochrome CYP1A isoforms in mammals...
  37. ncbi Polychlorinated biphenyls, cytochrome P450 1A1, and breast cancer risk in the Nurses' Health Study
    Francine Laden
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 11:1560-5. 2002
    ..99-7.82). The majority of studies have concluded that exposure to PCBs is unlikely to be a major cause of breast cancer, but these findings indicate that further studies of genetically susceptible populations are warranted...
  38. ncbi Effects of occupation, lifestyle and genetic polymorphisms of CYP1A1, CYP2E1, GSTM1 and GSTT1 on urinary 1-hydroxypyrene and 2-naphthol concentrations
    H M Nan
    Department of Preventive Medicine, College of Medicine, Chungbuk National University, South Korea
    Carcinogenesis 22:787-93. 2001
    ..In individuals not occupationally exposed to PAHs GSTM1 and smoking seem to influence the urinary concentration of 2-naphthol...
  39. ncbi 2,3,7,8-tetrachlorodibenzo-p-dioxin toxicity in the zebrafish embryo: local circulation failure in the dorsal midbrain is associated with increased apoptosis
    Wu Dong
    Department of Toxicology, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu 069 8501, Japan
    Toxicol Sci 69:191-201. 2002
    ..Taken together, these results suggest that TCDD induces apoptosis in the midbrain of the zebrafish embryo secondary to local circulation failure, which could be related to AHR activation, induction of CYP1A, and oxidative stress...
  40. ncbi A constitutively active dioxin/aryl hydrocarbon receptor promotes hepatocarcinogenesis in mice
    Oliver Moennikes
    Institut fur Pharmakologie und Toxikologie, Abteilung Toxikologie, Universitat Tubingen, Wilhelmstrasse 56, 72074 Tubingen, Germany
    Cancer Res 64:4707-10. 2004
    ....
  41. ncbi The human CYP1A1 gene is regulated in a developmental and tissue-specific fashion in transgenic mice
    Alema Galijatovic
    Laboratory of Environmental Toxicology, Department of Pharmacology, University of California, San Diego, La Jolla 92093, USA
    J Biol Chem 279:23969-76. 2004
    ..Combined these results indicate that tissue-specific and developmental factors are controlling aryl hydrocarbon receptor-mediated induction of human CYP1A1...
  42. pmc A constitutively active dioxin/aryl hydrocarbon receptor induces stomach tumors
    Patrik Andersson
    Department of Cell and Molecular Biology, Institute of Environmental Medicine, Karolinska Institute, S 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 99:9990-5. 2002
    ....
  43. ncbi Resistance of MCF-7 cells to dimethylbenz(a)anthracene-induced apoptosis is due to reduced CYP1A1 expression
    Henry P Ciolino
    Cellular Defense and Carcinogenesis Section, Basic Research Laboratory, Center for Cancer Research, National Cancer Institute at Frederick, National Institutes of Health, Frederick, MD 21702 1201, USA
    Int J Oncol 21:385-91. 2002
    ..These data demonstrate that AH resistance in these cells is mediated by changes in the signal transduction pathway which regulates CYP1A1 expression...
  44. ncbi Relationship of tobacco smoking CYP1A1 GSTM1 gene polymorphism and esophageal cancer in Xi'an
    An hui Wang
    Department of Epidemiology, Faculty of Preventive Medicine, Fourth Military Medical University Xi an 710032, Shaanxi Province, China
    World J Gastroenterol 8:49-53. 2002
    ..To analyze the association of tobacco smoking polymorphism of CYP1A1 (7th exon) and GSTM1 genotype and esophageal cancer(EC) in Xi'an...
  45. ncbi Influence of genetic polymorphisms of CYP1A1 and GSTM1 on the urinary levels of 1-hydroxypyrene
    P Apostoli
    Chair of Industrial Hygiene, Department of Experimental and Applied Medicine, University of Brescia, P le Spedali Civili, 1, Brescia 25123, Italy
    Toxicol Lett 144:27-34. 2003
    ..No influence of the genetic polymorphism of CYP1A1 and GSTM1 on the urinary levels of 1-OH-P was observed in this study...
  46. ncbi Polychlorinated biphenyls, cytochrome P4501A1 polymorphism, and postmenopausal breast cancer risk
    K B Moysich
    Department of Social and Preventive Medicine, SUNY Buffalo, New York 14214, USA
    Cancer Epidemiol Biomarkers Prev 8:41-4. 1999
    ..These results should be considered preliminary, pending replication by other studies...
  47. ncbi Oral exposure to benzo[a]pyrene in the mouse: detoxication by inducible cytochrome P450 is more important than metabolic activation
    Shigeyuki Uno
    Department of Environmental Health, Center for Environmental Genetics, University of Cincinnati Medical Center, OH 45267 0056, USA
    Mol Pharmacol 65:1225-37. 2004
    ....
  48. pmc In vitro evaluation of amino acid prodrugs of novel antitumour 2-(4-amino-3-methylphenyl)benzothiazoles
    T D Bradshaw
    Cancer Research Laboratories, School of Pharmaceutical Sciences, University of Nottingham, Nottingham NG7 2RD, UK
    Br J Cancer 86:1348-54. 2002
    ..Amino acid prodrugs meet the criteria of aqueous solubility, chemical stability and quantitative reversion to parent molecule, and thus are suitable for in vivo preclinical evaluation...
  49. ncbi Aryl hydrocarbon receptor mediates sensitivity of MCF-7 breast cancer cells to antitumor agent 2-(4-amino-3-methylphenyl) benzothiazole
    Andrea I Loaiza-Pérez
    Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    Mol Pharmacol 61:13-9. 2002
    ..These results suggest that clarification of the basis for differential engagement of AhR-related signaling in different tumor cell types may aid in further preclinical development and perhaps early clinical studies...
  50. ncbi Preclinical evaluation of amino acid prodrugs of novel antitumor 2-(4-amino-3-methylphenyl)benzothiazoles
    Tracey D Bradshaw
    Cancer Research Laboratories, School of Pharmaceutical Sciences, University of Nottingham, Nottingham NG7 2RD, United Kingdom
    Mol Cancer Ther 1:239-46. 2002
    ..The lysyl amide prodrug of 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole is potentially suitable for clinical evaluation...
  51. ncbi Genetic susceptibility and environmental factors of esophageal cancer in Xi'an
    An hui Wang
    Department of Epidemiology, Faculty of Preventive Medicine, Fourth Military Medical University, Xi an 710033, Shanxi Province, China
    World J Gastroenterol 10:940-4. 2004
    ..To analyse the role of genetic susceptibility and environmental factors in the process of esophageal cancer (EC) formation in Xi'an, China...
  52. ncbi Constitutive regulation of CYP1B1 by the aryl hydrocarbon receptor (AhR) in pre-malignant and malignant mammary tissue
    Xinhai Yang
    Department of Environmental Health, Boston University School of Public Health, Boston, Massachusetts 02118, USA
    J Cell Biochem 104:402-17. 2008
    ..These studies suggest that constitutively active AhR mediates different molecular outcomes than environmental chemical-activated AhR, and further implicate the AhR in mammary tumorigenesis...
  53. ncbi Genetic polymorphisms of drug-metabolizing enzymes and susceptibility to oral cavity cancer
    Matthias Hahn
    Institute of Pathology, Department of Medicine of the Ruprecht Karls University Heidelberg, Theodor Kutzer Ufer, 68135 Mannheim, Germany
    Oral Oncol 38:486-90. 2002
    ..587). Almost identical genotype distributions between cases and controls were found for all three NAT2 acetylators. Hence, these three genetic polymorphisms are unlikely to be associated with oral cavity cancer in the population studied...
  54. ncbi 2,3,7,8-Tetrachlorodibenzo-p-dioxin induces apoptotic cell death and cytochrome P4501A expression in developing Fundulus heteroclitus embryos
    B H Toomey
    Nicholas School of the Environment, Duke University, Durham, NC 27709, USA
    Aquat Toxicol 53:127-38. 2001
    ..In addition the dose response relationships for apoptosis and mortality were similar, while CYP1A expression appeared more sensitive to TCDD induction...
  55. ncbi Role of human cytochrome P450 (CYP) in the metabolic activation of N-alkylnitrosamines: application of genetically engineered Salmonella typhimurium YG7108 expressing each form of CYP together with human NADPH-cytochrome P450 reductase
    K Fujita
    Laboratory of Drug Metabolism, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita-Ku N12W6, 060-0812, Sapporo, Japan
    Mutat Res 483:35-41. 2001
    ..CYP2A6 played major roles in the activation of NDEA, NDPA, NMPA, NMBA and NEBA. Interestingly, CYP1A1 became a molecular form of CYP playing a major role in the metabolic activation of NDBA...
  56. ncbi Immunohistochemical localization of thyroid stimulating hormone induced by a low oral dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin in female Sprague-Dawley rats
    Noriko Nishimura
    Environmental Health Sciences Division, National Institute for Environmental Studies, 16 2 Onogawa, 305 8506, Tsukuba, Japan
    Toxicology 171:73-82. 2002
    ....
  57. ncbi Role of coactivators in transcriptional activation by the aryl hydrocarbon receptor
    Oliver Hankinson
    Department of Pathology and Laboratory Medicine, Molecular Biology Institute, and Jonsson Comprehensive Cancer Center, School of Medicine, University of California, Los Angeles, CA 90095, USA
    Arch Biochem Biophys 433:379-86. 2005
    ....
  58. ncbi Genetic polymorphism of cytochrome P4501A1 and susceptibility to oral squamous cell carcinoma and oral precancer lesions associated with smoking/betel use
    Shou Yen Kao
    Department of Dentistry, Oral and Maxillofacial Surgery, Taipei Veterans General Hospital, Taiwan, ROC
    J Oral Pathol Med 31:505-11. 2002
    ..It is also important to evaluate the association between CYP1A1 polymorphisms and susceptibility of oral precancerous lesion (OPL) to confirm the findings in OSCC cases...
  59. ncbi The effect of synthetic glucocorticoid, dexamethasone on CYP1A1 inducibility in adult rat and human hepatocytes
    Katalin Monostory
    Chemical Research Center, Hungarian Academy of Sciences, PO Box 17, H 1525 Budapest, Hungary
    FEBS Lett 579:229-35. 2005
    ..Dexamethasone potentiates the induction of CYP1A1 about 3- to 4-fold in rat cells. In human hepatocytes, it reduces CYP1A1 induction by 50-60% at enzyme protein level, while it does not have an effect on CYP1A1 mRNA amount...
  60. ncbi Polymorphism in CYP1A1 and CYP2E1 genes and susceptibility to leukoplakia in Indian tobacco users
    Nilabja Sikdar
    Anthropology and Human Genetics Unit, Biological Sciences Division, Indian Statistical Institute, 203 B T Road, Kolkata 700108, India
    Cancer Lett 195:33-42. 2003
    ..But the low sample size limited the power to precisely estimate the tobacco-genotype interactions...
  61. ncbi Characterization of the oxidative metabolites of 17beta-estradiol and estrone formed by 15 selectively expressed human cytochrome p450 isoforms
    Anthony J Lee
    Department of Basic Pharmaceutical Sciences, College of Pharmacy, University of South Carolina, Columbia, South Carolina 29208, USA
    Endocrinology 144:3382-98. 2003
    ..In conclusion, many human CYP isoforms are involved in the oxidative metabolism of 17beta-estradiol and estrone, with a varying degree of catalytic activity and distinct regioselectivity...
  62. ncbi Interactions between the aryl hydrocarbon receptor and P-TEFb. Sequential recruitment of transcription factors and differential phosphorylation of C-terminal domain of RNA polymerase II at cyp1a1 promoter
    Yanan Tian
    Department of Veterinary Physiology and Pharmacology, MS 4466, Texas A and M University, College Station, Texas 77843, USA
    J Biol Chem 278:44041-8. 2003
    ..Finally, we show that ligand-activated AhR associated with P-TEFb through the C terminus of cyclin T1, suggesting that AhR recruit the P-TEFb to the cyp1a1 promoter whereupon its kinase subunit phosphorylates the RNA PII CTD...
  63. ncbi The presence of inducible cytochrome P450 types 1A1 and 1A2 in the BeWo cell line
    M L Avery
    Department of Pharmaceutical Chemistry, School of Pharmacy, The University of Kansas, Lawrence 66047, USA
    Placenta 24:45-52. 2003
    ..These results show that major cytochrome P450 forms present in human placenta are present and inducible in BeWo cells, a potential model for investigation of drug metabolism mechanisms in the human trophoblast...
  64. ncbi Physiological role of the N-terminal processed P4501A1 targeted to mitochondria in erythromycin metabolism and reversal of erythromycin-mediated inhibition of mitochondrial protein synthesis
    H K Anandatheerthavarada
    Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6047, USA
    J Biol Chem 274:6617-25. 1999
    ..These results for the first time suggest a physiological function for the xenobiotic inducible cytochrome P4501A1 against drug-mediated mitochondrial toxicity...
  65. ncbi Activation of mitogen-activated protein kinases (MAPKs) by aromatic hydrocarbons: role in the regulation of aryl hydrocarbon receptor (AHR) function
    Zongqing Tan
    Department of Environmental Health, Center for Environmental Genetics, University of Cincinnati Medical Center, Cincinnati, OH 45267 0056, USA
    Biochem Pharmacol 64:771-80. 2002
    ..These data indicate that AHR ligands elicit AHR-independent non-genomic events that are essential for AHR activation and function...
  66. ncbi Sex differences in lung CYP1A1 expression and DNA adduct levels among lung cancer patients
    S Mollerup
    Department of Toxicology, National Institute of Occupational Health, Oslo, Norway
    Cancer Res 59:3317-20. 1999
    ..50, P = 0.009). In conclusion, the observed sex difference in aromatic/hydrophobic DNA adduct levels may at least in part be explained by different levels of CYP1A1 expression...
  67. ncbi A C4887A polymorphism in exon 7 of human CYP1A1: population frequency, mutation linkages, and impact on lung cancer susceptibility
    I Cascorbi
    Institute of Clinical Pharmacology, University Clinic Charite, Humboldt University of Berlin, Germany
    Cancer Res 56:4965-9. 1996
    ..87% (95% confidence limits, 1.32%, 5.37%); it was 2.87% (95% confidence limits, 1.71%, 4.49%) in 314 controls matched by age and sex. Thus, the novel m4-mutation may not represent a susceptibility factor for lung cancer...
  68. ncbi Interaction of cytochrome P4501A1 genotypes with other risk factors and susceptibility to lung cancer
    Parag P Shah
    Developmental Toxicology Division, Industrial Toxicology Research Centre, Lucknow 226001, India
    Mutat Res 639:1-10. 2008
    ....
  69. ncbi Dose-dependent titration of prorenin and blood pressure in Cyp1a1ren-2 transgenic rats: absence of prorenin-induced glomerulosclerosis
    Barbara Peters
    Department of Cardiovascular Medicine, University of Greifswald, Greifswald, Germany
    J Hypertens 26:102-9. 2008
    ..In cyp1a1ren-2 transgenic rats, prorenin levels and arterial pressure can be increased by oral administration of indole-3-carbinol (I3C). The transgenic strain has been used as a model of malignant hypertension...
  70. pmc Regulation of cytochrome P4501A1 expression by hyperoxia in human lung cell lines: Implications for hyperoxic lung injury
    Kushal Y Bhakta
    Department of Pediatrics, Section of Neonatology, Baylor College of Medicine, Houston, Texas, USA
    Toxicol Appl Pharmacol 233:169-78. 2008
    ..This novel finding of induction of CYP1A1 in the absence of exogenous AHR ligands could lead to novel interventions in the treatment of BPD...
  71. pmc Flavonoids as aryl hydrocarbon receptor agonists/antagonists: effects of structure and cell context
    Shu Zhang
    Department of Veterinary Physiology and Pharmacology, Texas AM University, College Station 77843 4466, USA
    Environ Health Perspect 111:1877-82. 2003
    ....
  72. ncbi In vivo and in vitro inhibition of CYP1A-dependent activity in Fundulus heteroclitus by the polynuclear aromatic hydrocarbon fluoranthene
    K L Willett
    Department of Pharmacology and Environmental Toxicology Research Program, University of Mississippi, University, Mississippi 38677 1848, USA
    Toxicol Appl Pharmacol 177:264-71. 2001
    ..Because FL and perhaps other inhibitory PAHs, co-occur in the environment with CYP1A inducers, CYP1A-dependent bioassays may cause an underestimation of PAH exposures...
  73. ncbi Antitumor benzothiazoles. 14. Synthesis and in vitro biological properties of fluorinated 2-(4-aminophenyl)benzothiazoles
    I Hutchinson
    Cancer Research Laboratories, School of Pharmaceutical Sciences, University of Nottingham, Nottingham NG7 2RD, United Kingdom
    J Med Chem 44:1446-55. 2001
    ..Induction of cytochrome P450 CYP1A1, a crucial event in determining the antitumor specificity of this series of benzothiazoles, was not compromised. 10h is currently the focus of pharmaceutical and preclinical development...
  74. ncbi A dioxin sensitive gene, mammalian WAPL, is implicated in spermatogenesis
    Masahiko Kuroda
    Department of Pathology, Tokyo Medical University, 6 1 1 Shinjuku, Shinjuku ku, Tokyo 160 8402, Japan
    FEBS Lett 579:167-72. 2005
    ..Thus, mammalian WAPL such as hWAPL and mWAPL may be involved in spermatogenesis and be target genes mediating the reproductive toxicity induced by TCDD...
  75. pmc Genetic polymorphisms in biotransformation enzymes in Crohn's disease: association with microsomal epoxide hydrolase
    D J de Jong
    Department of Gastroenterology and Hepatology, University Medical Centre Nijmegen, The Netherlands
    Gut 52:547-51. 2003
    ..As chemical or oxidative stress may be involved in the aetiology of Crohn's disease, genes encoding for enzymes involved in the prevention of such stress may be candidates for genetic susceptibility to Crohn's disease...
  76. ncbi Requirement of aryl hydrocarbon receptor overexpression for CYP1B1 up-regulation and cell growth in human lung adenocarcinomas
    Jinghua Tsai Chang
    Institute of Medical and Molecular Toxicology, Chung Shan Medical University, Taiwan, ROC
    Clin Cancer Res 13:38-45. 2007
    ..We examined the association between AhR, CYP1B1, and CYP1A1 expression in noninvasive bronchioloalveolar carcinomas (BAC) and lung adenocarcinomas and investigated the effects of AhR overexpression on cell physiology...
  77. pmc Crosstalk between the aryl hydrocarbon receptor and hypoxia on the constitutive expression of cytochrome P4501A1 mRNA
    Nan Zhang
    College of Pharmacy, University of New Mexico Health Sciences Center, 2703 Frontier NE, Albuquerque, NM 87131 5691, USA
    Cardiovasc Toxicol 7:282-90. 2007
    ..In conclusion, constitutive CYP1A1 mRNA expression is dependent on AHR and is reduced by hypoxia via a HIF-2alpha-dependent mechanism, which may be mediated by a HIF-2alpha-dependent reduction of AHR expression...
  78. ncbi Risk potentials for humans of original and remediated PAH-contaminated soils: application of biomarkers of effect
    Peter H Roos
    Institute of Occupational Physiology, University of Dortmund, Ardeystr 67, D 44139 Dortmund, Germany
    Toxicology 205:181-94. 2004
    ..This concerns, for example, the identification of the suitable animal model, the identification of biomarkers for other contaminants and concepts to transpose the in vivo data to in vitro technologies or to mathematical modelling...
  79. ncbi Juvenile sea bass liver P450, EROD induction, and erythrocytic genotoxic responses to PAH and PAH-like compounds
    C Gravato
    Animal Physiology Ecotoxicology Sector, University of Aveiro, 3810 193 Aveiro, Portugal
    Ecotoxicol Environ Saf 51:115-27. 2002
    ..Despite the low liver P450 content and EROD activity induction by NAPH and B(a)P, their genotoxic potential was higher than that of BNF...
  80. pmc Functional interference between hypoxia and dioxin signal transduction pathways: competition for recruitment of the Arnt transcription factor
    K Gradin
    Department of Medical Nutrition, Karolinksa Institute, Huddinge, Sweden
    Mol Cell Biol 16:5221-31. 1996
    ..Given the critical role of hsp90 for ligand binding activity and activation of the dioxin receptor, it is therefore possible that HIF-1 alpha is regulated by a similar mechanism, possibly by binding an as yet unknown class of ligands...
  81. pmc Resveratrol inhibits benzo[a]pyrene-DNA adduct formation in human bronchial epithelial cells
    G Berge
    Department of Toxicology, National Institute of Occupational Health, PO Box 8149 Dep, Oslo N 0033, Norway
    Br J Cancer 91:333-8. 2004
    ..In conclusion, these data lend support to a chemopreventive role of resveratrol in polycyclic aromatic hydrocarbon-induced carcinogenesis...
  82. ncbi Route-specific cellular expression of cytochrome P4501A (CYP1A) in fish (Fundulus heteroclitus) following exposure to aqueous and dietary benzo[a]pyrene
    P A Van Veld
    College of William and Mary, Virginia Institute of Marine Science, School of Marine Science, Gloucester Point 23062, USA
    Toxicol Appl Pharmacol 142:348-59. 1997
    ..The results of this study support the use of tissue-specific patterns of CYP1A expression in identification of target sites and exposure routes for polycyclic aromatic hydrocarbons and other compounds...
  83. ncbi Expression and function of ABCB1 and ABCG2 in human placental tissue
    Dhanashri Kolwankar
    Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, 308 Harvard St SE, Minneapolis, MN 55455, USA
    Drug Metab Dispos 33:524-9. 2005
    ..In summary, both ABCB1 and ABCG2 are expressed at high levels in human placenta and are functionally active, suggesting a protective role with respect to fetal exposure to xenobiotics ingested by the mother...
  84. pmc Phenotype of the Cyp1a1/1a2/1b1-/- triple-knockout mouse
    Nadine Dragin
    Department of Environmental Health, University of Cincinnati Medical Center, P O Box 670056, Cincinnati, OH 45267 0056, USA
    Mol Pharmacol 73:1844-56. 2008
    ....
  85. ncbi CYP1A1 gene polymorphism and risk of epithelial ovarian neoplasm
    Dilek Aktas
    Department of Genetics, Hacettepe University Medical School, 06100, Sihhiye, Ankara, Turkey
    Gynecol Oncol 86:124-8. 2002
    ..Therefore, we assessed the association of CYP1A1 gene polymorphism in patients with epithelial ovarian neoplasm in the Turkish populations through a case-control study...
  86. ncbi Increased arylhydrocarbon receptor expression offers a potential therapeutic target for pancreatic cancer
    Alexander Koliopanos
    Department of Visceral and Transplantation Surgery, University of Bern, Inselspital, Switzerland
    Oncogene 21:6059-70. 2002
    ..In addition, almost all human pancreatic cancer tissues expressed this receptor at high levels, suggesting that these or related compounds may play a role in the therapy of pancreatic cancer in the future...
  87. ncbi CYP1A1 Val462 and NQO1 Ser187 polymorphisms, cigarette use, and risk for colorectal adenoma
    Lifang Hou
    Department of Human and Health Services, Division of Cancer Epidemiology and Genetics, Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 7240, USA
    Carcinogenesis 26:1122-8. 2005
    ..002). In summary, joint carriage of CYP1A1 Val(462) and NQO1 Ser(187) alleles, particularly in smokers, was related to colorectal adenoma risk, with a propensity for formation of multiple lesions...
  88. ncbi Conditional deletion of cytochrome P450 oxidoreductase in the liver and gastrointestinal tract: a new model for studying the functions of the P450 system
    Robert D Finn
    Cancer Research UK Molecular Pharmacology Unit, Biomedical Research Centre, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    J Pharmacol Exp Ther 322:40-7. 2007
    ..This model provides a powerful approach for studying the functions of POR as well as in the evaluation of the role of hepatic and gastrointestinal P450s in drug deposition and chemical toxicity...
  89. ncbi CYP1A1 and GSTM1 genotypes affect benzo[a]pyrene DNA adducts in smokers' lung: comparison with aromatic/hydrophobic adduct formation
    Kroum Alexandrov
    German Cancer Research Center DKFZ, Division of Toxicology and Cancer Risk Factors, P O Box 101949, D 69009 Heidelberg, Germany
    Carcinogenesis 23:1969-77. 2002
    ....
  90. ncbi Null type of glutathione S-transferase M1 polymorphism is associated with early onset pterygium
    Yi Yu Tsai
    Department of Ophthalmology, China Medical University Hospital and Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan
    Mol Vis 10:458-61. 2004
    ..To investigate the association of glutathione S-transferase M1 (GSTM1) null genotype with pterygium...
  91. ncbi Chromium inhibits transcription from polycyclic aromatic hydrocarbon-inducible promoters by blocking the release of histone deacetylase and preventing the binding of p300 to chromatin
    Yu Dan Wei
    Center for Environmental Genetics and Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio 45220 0056, USA
    J Biol Chem 279:4110-9. 2004
    ..These results provide a mechanistic explanation for the observation that chromium inhibits inducible but not constitutive gene expression...
  92. ncbi Effects of polybrominated diphenyl ethers on basal and TCDD-induced ethoxyresorufin activity and cytochrome P450-1A1 expression in MCF-7, HepG2, and H4IIE cells
    A K Peters
    Institute for Risk Assessment Sciences, Utrecht University, PO Box 80176, 3508 TD Utrecht, The Netherlands
    Toxicol Sci 82:488-96. 2004
    ..However, inhibition of luciferase induction in mouse (Hepa) and rat (H4IIE) hepatoma cells containing a stably transfected AhR-responsive luciferase reporter gene, suggests that BDE77 is a weak AhR antagonist or partial agonist...
  93. ncbi The development of the antitumour benzothiazole prodrug, Phortress, as a clinical candidate
    T D Bradshaw
    Centre for Biomolecular Sciences, School of Pharmacy, University of Nottingham, University Park, Nottingham NG7 2RD, UK
    Curr Med Chem 11:1009-21. 2004
    ..Aspects of mechanism of action studies, in vitro and in vivo screening, synthetic chemistry and pharmacokinetics are reviewed here...
  94. ncbi Pooled analysis of the CYP1A1 exon 7 polymorphism and lung cancer (United States)
    Loic Le Marchand
    Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI 96813, USA
    Cancer Causes Control 14:339-46. 2003
    ....
  95. ncbi DRESSA: biosensing of dioxin and dioxin-like chemicals using secreted alkaline phosphatase
    Ayumi Kasai
    Department of Biochemistry, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Tamaho, Yamanashi 409 3898, Japan
    Anal Biochem 335:73-80. 2004
    ....
  96. ncbi Aryl hydrocarbon receptor activation of an antitumor aminoflavone: basis of selective toxicity for MCF-7 breast tumor cells
    Andrea I Loaiza-Pérez
    Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute Frederick, Building 322, Room 104, Frederick, MD 21702, USA
    Mol Cancer Ther 3:715-25. 2004
    ..These results suggest that the cytotoxicity of aminoflavone in a sensitive breast tumor cell line is the result of the engagement of AhR-mediated signal transduction...
  97. ncbi Polymorphisms in steroid hormone pathway genes and mammographic density
    Christopher A Haiman
    Department of Epidemiology, Harvard School of Public Health Boston, MA, USA
    Breast Cancer Res Treat 77:27-36. 2003
    ..However, our findings of differences in associations for UGT1A1 and AIB1 genotypes with breast density by menopausal status needs additional corroboration...
  98. pmc DNA damage and cell cycle arrest induced by 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole (5F 203, NSC 703786) is attenuated in aryl hydrocarbon receptor deficient MCF-7 cells
    V Trapani
    School of Pharmaceutical Sciences, University of Nottingham, UK
    Br J Cancer 88:599-605. 2003
    ..The data confirm that activation of the AhR signalling pathway is an important feature of the antitumour activity of 5F 203...
  99. ncbi Relationships between tissue levels of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), mRNAs, and toxicity in the developing male Wistar(Han) rat
    David R Bell
    School of Biology, University of Nottingham, University Park, Nottingham NG7 2RD, United Kingdom
    Toxicol Sci 99:591-604. 2007
    ..These data characterize the maternal and fetal disposition of TCDD, induction of CYP1A1 RNA as a measure of AhR activation, and suggest that lactational transfer of TCDD determines the difference in delay in BPS between the two studies...
  100. ncbi An evidence for regulatory cross-talk between aryl hydrocarbon receptor and glucocorticoid receptor in HepG2 cells
    Z Dvorak
    Institute of Medical Chemistry and Biochemistry, Faculty of Medicine, Palacky University Olomouc, Hnevotinska 3, Olomouc, Czech Republic
    Physiol Res 57:427-35. 2008
    ..Future research should be focused on the investigation of AhR-GR cross-talk in various normal human cells and tissues both in vitro and in vivo...
  101. ncbi Association of CYP1A1 polymorphisms with breast cancer in North Indian women
    Neetu Singh
    Genotoxicity Laboratory, Toxicology Division, Central Drug Research Institute, Lucknow 226 001, Uttar Pradesh, India
    Oncol Res 16:587-97. 2007
    ..This indicates that out of ml and m2 polymorphisms that have been reported in Asians, only m2 is associated with North Indians...

Research Grants64

  1. CYP1A1 GENOTYPE & INDUCIBIL PHENOTYPE-HUM LUNG CA RISK
    Jennifer Hu; Fiscal Year: 1992
    ....
  2. BREAST CANCER RISK--RESIDENTIAL ENVIRONMENT AND GENETICS
    Jo Freudenheim; Fiscal Year: 2001
    ..This is a unique and cost effective opportunity to examine a hypothesis of potentially great public health importance in a relatively residentially stable population. ..
  3. GENE MUTATIONS IN ESTROGEN-INDUCED CARCINOGENESIS
    JOACHIM LIEHR; Fiscal Year: 1999
    ....
  4. MINORITY PREDOCTORAL FELLOWSHIP PROGRAM
    DEANNA WORMLEY; Fiscal Year: 2002
    ..LTP decrements and dysregulation of AhR, ARNT, and CYP 1A1/1A2 in the developing nervous system. These results will suggest that environmental mixtures play an antagonistic role in the development of the CNS. ..
  5. RECEPTOR MEDIATED OXIDATIVE STRESS
    HOWARD SHERTZER; Fiscal Year: 2003
    ..These studies will improve our understanding of how PHAHs such as TCDD generate oxidative stress and mutagenesis, leading to better models for risk assessment and novel strategies for intervention in PHAH-mediated toxicity. ..
  6. Carcinogenicity of Estrogens
    DAVID SPINK; Fiscal Year: 2009
    ..These studies may elucidate roles of estrogen in the regulation of Ah responsiveness, CYP1 expression, and carcinogen bioactivation that may lead to novel breast cancer chemoprevention strategies. ..
  7. Glutathione in Environmental Toxicity and Disease
    HOWARD SHERTZER; Fiscal Year: 2007
    ..Our proposed research should therefore help focus future genotype-phenotype association studies between the appropriate DNA variant sites in the GCLC and GCLM genes and disease. ..
  8. CYP1A1 GENE AND ENVIRONMENTAL TOXICITY
    Daniel Nebert; Fiscal Year: 2005
    ..abstract_text> ..
  9. PAHs: Balance of Detoxication vs Metabolic Activation
    Daniel Nebert; Fiscal Year: 2009
    ..dissemination of ingested BaP and will be informative in clinical studies in which we would determine which haplotypes of these three human genes might be associated with resistance vs. sensitivity to PAH-induced toxicity and cancer. ..
  10. Molecular Genetics of Cadmium Toxicity
    Daniel W Nebert; Fiscal Year: 2010
    ....
  11. GENOTOXICITY IN CYP1A2 DEFICIENT TRANSGENIC MICE
    Daniel Nebert; Fiscal Year: 2002
    ..S. population. ..
  12. The TGFbeta Pathway, Gene Variants and Colorectal Neopl*
    Loic Le Marchand; Fiscal Year: 2005
    ..abstract_text> ..
  13. Diet, Genetic Susceptibility and Colorectal Neoplasia
    Loic Le Marchand; Fiscal Year: 2006
    ..Genotyping for random markers will permit to exclude residual confounding by ethnicity. ..
  14. Ethnic/Racial Minorities in the Colon CFR
    Loic Le Marchand; Fiscal Year: 2008
    ..abstract_text> ..
  15. Molecular Epidemiology of Pancreatic Cancer
    Donghui Li; Fiscal Year: 2008
    ..Such information will be valuable for the primary prevention of this deadly disease. ..
  16. GENES, DIET AND CARCINOGEN ACTIVATION IN SMOKERS
    Loic Le Marchand; Fiscal Year: 2004
    ..The elucidation of the main enzymes responsible for carcinogen activation and of the impact of dietary factors on these enzymes would have important implications for cancer prevention. ..
  17. Case-Control Study of Adenoma in Sao Paulo Japanese
    Loic Le Marchand; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  18. Hawaii Colorectal Cancer Family Registry
    Loic Le Marchand; Fiscal Year: 2008
    ..We will also propose a CFR pilot study exploring the feasibility of assessing assorted mating as evidence for population stratification. ..
  19. Roles of CYP1 & 19 in Fundulus Steroids & PAH Metabolism
    Kristine Willett; Fiscal Year: 2009
    ..This research will further define the utility of Fundulus as a model organism for studying PAH-associated toxicities and in the development of human CYP19 or CYP1 B-related therapeutics. ..
  20. Cytochrome P450 regulation by hyperoxia and nitric oxide
    Xanthi Couroucli; Fiscal Year: 2006
    ..The studies will also help identify appropriate supportive therapies to minimize any adverse effects arising out of this clinically important therapy. ..
  21. Regulation of cyp1a1 by Ah Receptor and NFkB Interaction
    Yanan Tian; Fiscal Year: 2009
    ..The proposed studies will help us gain mechanistic understandings of the functions of AhR and NF-kB in normal physiology as well as pathogenesis induced by dioxin and related compounds. ..
  22. MECHANISM OF PORPHYRIA CAUSED BY TCDD
    Peter Sinclair; Fiscal Year: 2002
    ..II. To determine whether human CYP1A2 has an essential role in UROgen oxidation and the development of uroporphyria. III. To study the interaction of Fe and CYP1A2 in the development of uroporphyria. ..
  23. Analysis and Effect of Persistent Ah Receptor Activation
    Michael Denison; Fiscal Year: 2008
    ..abstract_text> ..
  24. Aldosterone in angiotensin II-induced hypertension
    Rudy Ortiz; Fiscal Year: 2005
    ..Unlike previous studies, the present study will provide a more comprehensive examination of the renal effects induced by aldo antagonism. ..
  25. SWAN Sleep Study II - Chicago (Rush) Site
    Howard Kravitz; Fiscal Year: 2008
    ..The results can inform primary prevention of adverse health outcomes due to the menopause-related sleep disturbances. ..
  26. CYTOKINES AS PREDICTORS OF DISEASE PROGRESSION IN SCLERODERMA LUNG DISEASE
    Michael Roth; Fiscal Year: 2009
    ..It will also allow us to develop biologic markers and predictors of disease progression and to determine which patients would benefit most from treatment with cytotoxic therapy. ..
  27. SCREENS TO IDENTIFY GAIN OF FUNCTION AH RECEPTOR MUTANTS INVOLVED IN DEGRADATION
    RICHARD POLLENZ; Fiscal Year: 2008
    ..e. steroid hormone receptors). [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  28. Molecular mechanisms of cytochrome P4501A regulation by hyperoxia
    Bhagavatula Moorthy; Fiscal Year: 2010
    ..Using animal and cell culture models, this project is aimed at developing rational strategies for the prevention and treatment of lung diseases (e.g. BPD and ARDS) associated with hyperoxia. ..
  29. METABOLISM OF CARCINOGENIC TOBACCO SPECIFIC NITROSAMINES
    Stephen Hecht; Fiscal Year: 2003
    ..abstract_text> ..
  30. CARCINOGEN ACTIVATION AND SCREENING IN VARIANT CELLS
    Oliver Hankinson; Fiscal Year: 2010
    ..abstract_text> ..
  31. DIET AND DURATION OF CERVICAL HPV INFECTION
    MARC GOODMAN; Fiscal Year: 2009
    ....
  32. Resistance and Response Mechanisms to Prostate Cancer Therapy
    TOMASZ BEER; Fiscal Year: 2009
    ..We will test the effectiveness of novel treatments that exploit newly discovered targets in the laboratory and lay the foundation for human trials to develop effective prostate cancer treatment. ..
  33. Change in Bone, Arthritis, Function: Hormones & Obesity
    MaryFran Sowers; Fiscal Year: 2009
    ....
  34. CARCINOGENIC CYCLIC NITROSAMINE DNA ADDUCTS
    Stephen S Hecht; Fiscal Year: 2010
    ..The proposed research is significant because of the known human exposure to these carcinogens through the diet, tobacco products, and endogenous formation. ..
  35. 2008 Oceans and Human Health Gordon Research Conference
    JOHN STEGEMAN; Fiscal Year: 2008
    ..The significance of the field is reflected by the support of Centers for Oceans and Human Health by the NIEHS and the National Science Foundation. [unreadable] [unreadable] [unreadable] [unreadable]..
  36. Functional Status and the Menopause Transition
    MaryFran R Sowers; Fiscal Year: 2010
    ..Among the elderly, older women live longer, develop more chronic disease and experience more prolonged and severe disability than older men. ..
  37. Telomere dysfunction, oxidative damage and breast cancer risk
    Jing Shen; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  38. Anticancer Potential of Black Cohosh on Breast Cancer
    LINDA EINBOND; Fiscal Year: 2007
    ..This research project could identify new approaches to breast cancer prevention and therapy. ..
  39. Sphingolipid signaling in olfactory mucosa
    Mary Beth Genter; Fiscal Year: 2004
    ..abstract_text> ..
  40. Acupuncture for hot flashes in prostate cancer patients
    TOMASZ BEER; Fiscal Year: 2004
    ..The overall goal is to provide prostate cancer patients an effective, low toxicity, non-pharmacologic treatment modality for hot flashes. ..
  41. NO, Genotype Dependent & Environment Specific Regulation
    Xing Li Wang; Fiscal Year: 2004
    ....
  42. Pharmacogenetic Epidemiology of Birth Defects and Cancer
    Timothy Rebbeck; Fiscal Year: 2004
    ....
  43. Chemoprevention in Mice after Tobacco Smoke Exposure
    Hanspeter Witschi; Fiscal Year: 2004
    ..Eventually, these preclinical studies in an animal model of "former smokers" will help to evaluate the potential usefulness and also possible dosage regimens of chemopreventive agents characterized by their suppressing action. ..
  44. IL-1 Beta influences on NGF in neural Development
    ANNA JELASO; Fiscal Year: 2003
    ..This work will establish a system for understanding how cytokines and neurotrophins interact during neural development to influence the development and/or maintenance of functional neural circuits. ..
  45. Hormones, DNA Repair, BRCA1/2 and Ovarian Cancer Preven*
    Francesmary Modugno; Fiscal Year: 2003
    ..The expertise and data we will collect will promote future innovative research into understanding ovarian cancer. ..
  46. Serum Markers of Breast /Ovarian Cancer Risk
    Francesmary Modugno; Fiscal Year: 2003
    ..We also expect to identify additional related research questions, which we anticipate studying further in a multi-center, collaborative fashion within the various arms of the WHI. ..
  47. Implications of Genomics Research on Racial Definition
    Seymour Garte; Fiscal Year: 2003
    ..A new paradigm of gene-specific variation will be developed for a biomedically useful method of division of the human population into groups based on criteria different from current definitions of race. ..
  48. MECHANISM OF INDUCTION OF OLFACTORY TUMORS BY ALACHLOR
    Mary Beth Genter; Fiscal Year: 2002
    ....
  49. IMPACT OF AH RECEPTOR DEGRADATION IN VIVO AND IN VITRO
    RICHARD POLLENZ; Fiscal Year: 2005
    ..abstract_text> ..
  50. ETHANOL METABOLISM IN PREGNANCY--ROLE OF DIET
    Martin Ronis; Fiscal Year: 2005
    ....
  51. FT-IR/GC-MS MODELS FOR PREDICTING PROSTATE CANCER
    DONALD MALINS; Fiscal Year: 2002
    ..At the conclusion of these studies we expect to have significantly increased understanding of the etiology of prostate cancer and established a promising basis for cancer prediction. ..
  52. Cytochrome P450-reductase interactions in P450 1A subfamily
    GRAZYNA SZKLARZ; Fiscal Year: 2007
    ..Furthermore, this project will also provide opportunities for summer research by undergraduate students, as part of WV-BRIN and WV-INBRE programs. [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  53. ETHANOL EFFECTS ON BONE FORMATION IN PREGNANCY
    Martin Ronis; Fiscal Year: 2006
    ..The role of CYP2E1 and free radicals in the skeletal toxicity of ethanol during these periods will also be studied. ..
  54. Individual Promoter SNP and CpG Methylation Signatures
    SIMON SPIVACK; Fiscal Year: 2006
    ..abstract_text> ..
  55. MENOPAUSAL TRANSITION: A BIOBEHAVIORAL MODEL OF SYMPTOMS
    Ellen Mitchell; Fiscal Year: 2006
    ..abstract_text> ..
  56. Estrogen, Metabolism, Menopause, and Health Outcomes
    MaryFran Sowers; Fiscal Year: 2006
    ..This is a unique opportunity to prospectively integrate lifestyle elements with measures of hormone metabolism pathways into a comprehensive examination of multiple human health effects. ..
  57. ARNT:Roles in Tumor Induction and Growth, and Toxicity.
    Oliver Hankinson; Fiscal Year: 2006
    ..abstract_text> ..
  58. Adjuvant immunotherapy for non-small cell lung cancer
    Michael Roth; Fiscal Year: 2005
    ..abstract_text> ..
  59. DNA Damage as Women Age: Implications for Breast Cancer
    DONALD MALINS; Fiscal Year: 2005
    ....
  60. Luminal Lipid Exposure, Genetics and Colon Cancer Risk
    Ikuko Kato; Fiscal Year: 2006
    ..In addition, accumulated dietary data and biological specimens will serve as an important resource for future research on other nutrient-gene interactions. ..
  61. "Ligand Independent" endocrine disruption by pesticides
    Patrick Wong; Fiscal Year: 2005
    ..abstract_text> ..
  62. Genetic Susceptibility to Infection Related Cancer
    Ikuko Kato; Fiscal Year: 2005
    ..Secondary aims include to examine histopathological correlates of these polymorphisms and to determine whether selected environmental factors modify the above associations. ..