thioctic acid

Summary

Summary: A vitamin-like antioxidant.

Top Publications

  1. pmc Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential
    Kate Petersen Shay
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331 6512, USA
    Biochim Biophys Acta 1790:1149-60. 2009
  2. ncbi Lipoic acid - biological activity and therapeutic potential
    Anna Goraca
    Department of Cardiovascular Physiology, Medical University of Lodz, Mazowiecka 6 8, PL 92 215 Łódź, Poland
    Pharmacol Rep 63:849-58. 2011
  3. pmc Toxoplasma gondii scavenges host-derived lipoic acid despite its de novo synthesis in the apicoplast
    Michael J Crawford
    Department of Biology, University of Pennsylvania, Philadelphia, USA
    EMBO J 25:3214-22. 2006
  4. ncbi Irbesartan and lipoic acid improve endothelial function and reduce markers of inflammation in the metabolic syndrome: results of the Irbesartan and Lipoic Acid in Endothelial Dysfunction (ISLAND) study
    Srikanth Sola
    Division of Cardiology, Emory University School of Medicine, Atlanta, GA 30303, USA
    Circulation 111:343-8. 2005
  5. ncbi Anti-obesity effects of alpha-lipoic acid mediated by suppression of hypothalamic AMP-activated protein kinase
    Min Seon Kim
    Department of Internal Medicine, University of Ulsan College of Medicine, 138 736 Poongnap dong, Songpa Ku, Seoul 138 736, Korea
    Nat Med 10:727-33. 2004
  6. ncbi The pharmacology of the antioxidant lipoic acid
    G P Biewenga
    Leiden Amsterdam Center for Drug Research, Vrije Universiteit, Department of Pharmacochemistry, The Netherlands
    Gen Pharmacol 29:315-31. 1997
  7. ncbi Lipoic acid prevents high-fat diet-induced dyslipidemia and oxidative stress: a microarray analysis
    Rui Li Yang
    State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, China
    Nutrition 24:582-8. 2008
  8. ncbi Lipoic acid as an anti-inflammatory and neuroprotective treatment for Alzheimer's disease
    Annette Maczurek
    Department of Pharmacology, School of Medicine, University of Western Sydney, Australia
    Adv Drug Deliv Rev 60:1463-70. 2008
  9. pmc A novel two-gene requirement for the octanoyltransfer reaction of Bacillus subtilis lipoic acid biosynthesis
    Natalia Martin
    Instituto de Biologia Molecular y Celular de Rosario IBR CONICET, Facultad de Ciencias Bioquimicas y Farmaceuticas, Universidad Nacional de Rosario, Suipacha 531, 2000 Rosario, Argentina
    Mol Microbiol 80:335-49. 2011
  10. ncbi Direct and indirect antioxidant properties of α-lipoic acid and therapeutic potential
    Luc Rochette
    Inserm UMR866, Laboratoire de Physiopathologie et Pharmacologie Cardio Métaboliques, Universite de Bourgogne, Facultés de Médecine et Pharmacie, 21000 Dijon, France
    Mol Nutr Food Res 57:114-25. 2013

Detail Information

Publications331 found, 100 shown here

  1. pmc Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential
    Kate Petersen Shay
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331 6512, USA
    Biochim Biophys Acta 1790:1149-60. 2009
    ..Current trials are investigating whether these beneficial properties of LA make it an appropriate treatment not just for diabetes, but also for the prevention of vascular disease, hypertension, and inflammation...
  2. ncbi Lipoic acid - biological activity and therapeutic potential
    Anna Goraca
    Department of Cardiovascular Physiology, Medical University of Lodz, Mazowiecka 6 8, PL 92 215 Łódź, Poland
    Pharmacol Rep 63:849-58. 2011
    ..This review was undertaken to gather the most recent information regarding the therapeutic properties of LA and its possible utility in disease treatment...
  3. pmc Toxoplasma gondii scavenges host-derived lipoic acid despite its de novo synthesis in the apicoplast
    Michael J Crawford
    Department of Biology, University of Pennsylvania, Philadelphia, USA
    EMBO J 25:3214-22. 2006
    ..Our studies thus reveal an unexpected metabolic deficiency in T. gondii and raise the question whether the close interaction of host mitochondria with the parasitophorous vacuole is connected to lipoate supply by the host...
  4. ncbi Irbesartan and lipoic acid improve endothelial function and reduce markers of inflammation in the metabolic syndrome: results of the Irbesartan and Lipoic Acid in Endothelial Dysfunction (ISLAND) study
    Srikanth Sola
    Division of Cardiology, Emory University School of Medicine, Atlanta, GA 30303, USA
    Circulation 111:343-8. 2005
    ..We evaluated the ability of irbesartan, an angiotensin receptor blocker, and lipoic acid, an antioxidant, to affect endothelial function and inflammation in patients with the metabolic syndrome...
  5. ncbi Anti-obesity effects of alpha-lipoic acid mediated by suppression of hypothalamic AMP-activated protein kinase
    Min Seon Kim
    Department of Internal Medicine, University of Ulsan College of Medicine, 138 736 Poongnap dong, Songpa Ku, Seoul 138 736, Korea
    Nat Med 10:727-33. 2004
    ..Our findings indicate that hypothalamic AMPK is important in the central regulation of food intake and energy expenditure and that alpha-LA exerts anti-obesity effects by suppressing hypothalamic AMPK activity...
  6. ncbi The pharmacology of the antioxidant lipoic acid
    G P Biewenga
    Leiden Amsterdam Center for Drug Research, Vrije Universiteit, Department of Pharmacochemistry, The Netherlands
    Gen Pharmacol 29:315-31. 1997
    ..10. Within drug-related antioxidant pharmacology, lipoic acid is a model compound that enhances understanding of the mode of action of antioxidants in drug therapy...
  7. ncbi Lipoic acid prevents high-fat diet-induced dyslipidemia and oxidative stress: a microarray analysis
    Rui Li Yang
    State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, China
    Nutrition 24:582-8. 2008
    ..To elucidate the molecular mechanisms of that effect, we carried out experiments aimed at analyzing biochemical parameters and gene expression profiles...
  8. ncbi Lipoic acid as an anti-inflammatory and neuroprotective treatment for Alzheimer's disease
    Annette Maczurek
    Department of Pharmacology, School of Medicine, University of Western Sydney, Australia
    Adv Drug Deliv Rev 60:1463-70. 2008
    ....
  9. pmc A novel two-gene requirement for the octanoyltransfer reaction of Bacillus subtilis lipoic acid biosynthesis
    Natalia Martin
    Instituto de Biologia Molecular y Celular de Rosario IBR CONICET, Facultad de Ciencias Bioquimicas y Farmaceuticas, Universidad Nacional de Rosario, Suipacha 531, 2000 Rosario, Argentina
    Mol Microbiol 80:335-49. 2011
    ..coliΔlipB strain can be complemented with lipM, but not lipL. These data together with those of the companion article provide evidence that LipM and LipL catalyse sequential reactions in a novel pathway for lipoic acid biosynthesis...
  10. ncbi Direct and indirect antioxidant properties of α-lipoic acid and therapeutic potential
    Luc Rochette
    Inserm UMR866, Laboratoire de Physiopathologie et Pharmacologie Cardio Métaboliques, Universite de Bourgogne, Facultés de Médecine et Pharmacie, 21000 Dijon, France
    Mol Nutr Food Res 57:114-25. 2013
    ..The complex and intimate association between increased oxidative stress and increased inflammation in related disorders such as diabetes, makes it difficult to establish the temporal sequence of the relationship...
  11. ncbi Assembly of the covalent linkage between lipoic acid and its cognate enzymes
    Xin Zhao
    Department of Microbiology, University of Illinois, Urbana, IL 61801, USA
    Chem Biol 10:1293-302. 2003
    ..coli strain devoid of LipA activity. The labeled octanoyl domain was converted to lipoylated domain upon restoration of LipA. Moreover, octanoyl domain and octanoyl-PDH were substrates for sulfur insertion in vitro...
  12. ncbi A systematic review and meta-analysis of α-lipoic acid in the treatment of diabetic peripheral neuropathy
    Tingting Han
    Department of Endocrinology, Renji Hospital, Shanghai Jiaotong University, 200127 Shanghai, China
    Eur J Endocrinol 167:465-71. 2012
    ..To evaluate the effects and safety of 300-600 mg α-lipoic acid (ALA) given i.v. for diabetic peripheral neuropathy (DPN)...
  13. ncbi Ameliorating effect of DL-α-lipoic acid against cisplatin-induced nephrotoxicity and cardiotoxicity in experimental animals
    Asmma Hussein
    Department of Pharmacology and Toxicology, Faculty of Pharmacy, Omar Al Mukhtar University, Al Bayda, Libya
    Drug Discov Ther 6:147-56. 2012
    ..In conclusion, LA is suggested to be a potential candidate to ameliorate cisplatin-induced nephrotoxicity and cardiotoxicity without altering the antitumor efficacy of cisplatin...
  14. ncbi Neuroprotection of lipoic acid treatment promotes angiogenesis and reduces the glial scar formation after brain injury
    B Rocamonde
    Facultad Ciencias de Salud, Universidad CEU Cardenal Herrera, Moncada, Valencia, Spain
    Neuroscience 224:102-15. 2012
    ..These findings open new possibilities for restorative strategies after brain injury, stroke or related disorders...
  15. ncbi Beneficial effects of alpha-lipoic acid plus vitamin E on neurological deficit, reactive gliosis and neuronal remodeling in the penumbra of the ischemic rat brain
    O Gonzalez-Perez
    Division de Neurociencias, Centro de Investigación Biomédica de Occidente CIBO del Instituto Mexicano del Seguro Social IMSS, Sierra Mojada 800, Guadalajara Jalisco 44340, Mexico
    Neurosci Lett 321:100-4. 2002
    ..The beneficial effects of this antioxidant mixture suggest that it may be valuable for the treatment of cerebral ischemia in humans...
  16. ncbi α-lipoic acid prevents non-alcoholic fatty liver disease in OLETF rats
    Tae Sik Jung
    Department of Internal Medicine, Institute of Health Sciences, Gyeongsang National University School of Medicine, Jinju, Gyeongnam, Republic of Korea
    Liver Int 32:1565-73. 2012
    ..The powerful antioxidant α-lipoic acid (ALA) has been shown to improve insulin sensitivity and suppress inflammatory responses. This study explores how ALA administration protects against NAFLD...
  17. ncbi The oxidative stress and the mitochondrial dysfunction caused by endotoxemia are prevented by alpha-lipoic acid
    Virginia Vanasco
    Laboratory of Free Radical Biology, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina
    Free Radic Res 42:815-23. 2008
    ..The treatment with LA prevented the oxidative stress and mitochondrial dysfunction observed in this model...
  18. pmc Nrf2-dependent induction of proteasome and Pa28αβ regulator are required for adaptation to oxidative stress
    Andrew M Pickering
    Ethel Percy Andrus Gerontology Center of the Davis School of Gerontology, University of Southern California, Los Angeles, California 90089, USA
    J Biol Chem 287:10021-31. 2012
    ..Thus, immunoproteasome appears to be (at most) minimally regulated by the Nrf2 signal transduction pathway...
  19. pmc Dietary fructose accelerates the development of diabetes in UCD-T2DM rats: amelioration by the antioxidant, alpha-lipoic acid
    Bethany P Cummings
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California Davis, One Shields Ave, Davis, CA 95616, USA
    Am J Physiol Regul Integr Comp Physiol 298:R1343-50. 2010
    ..In conclusion, dietary fructose accelerates the onset of T2DM in UCD-T2DM rats, and LA ameliorates the effects of fructose by improving glucose homeostasis, possibly by preserving beta-cell function...
  20. pmc A fatal mitochondrial disease is associated with defective NFU1 function in the maturation of a subset of mitochondrial Fe-S proteins
    Aleix Navarro-Sastre
    Division of Inborn Errors of Metabolism, Department of Biochemistry and Molecular Genetics, Hospital Clinic, Instituto de Investigación Biomédica Pi Sunyer, 08028 Barcelona, Spain
    Am J Hum Genet 89:656-67. 2011
    ..Importantly, yeast Nfu1 protein carrying the individuals' missense mutation was functionally impaired. We conclude that NFU1 functions as a late-acting maturation factor for a subset of mitochondrial Fe-S proteins...
  21. pmc Lipoic acid metabolism in microbial pathogens
    Maroya D Spalding
    Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Room E5132, Baltimore, MD 21205, USA
    Microbiol Mol Biol Rev 74:200-28. 2010
    ..This review surveys the role of lipoate metabolism in bacterial, fungal, and protozoan pathogens and how these organisms have employed this metabolism to adapt to niche environments...
  22. ncbi Function, attachment and synthesis of lipoic acid in Escherichia coli
    John E Cronan
    Department of Microbiology, University of Illinois, Urbana, IL 61801, USA
    Adv Microb Physiol 50:103-46. 2005
    ..Homologues of the lipoic acid metabolism proteins are found in all branches of life, save the Archea, and thus these findings seem to have wide biological relevance...
  23. ncbi Pathogenesis of ganglion "cell death" in glaucoma and neuroprotection: focus on ganglion cell axonal mitochondria
    Neville N Osborne
    Nuffield Laboratory of Ophthalmology, University of Oxford, Walton Street, Oxford OX2 6AW, UK
    Prog Brain Res 173:339-52. 2008
    ....
  24. ncbi Beneficial effects of creatine, CoQ10, and lipoic acid in mitochondrial disorders
    M Christine Rodriguez
    Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada
    Muscle Nerve 35:235-42. 2007
    ..Future studies with larger sample sizes in relatively homogeneous groups will be required to determine whether such combination therapies influence function and quality of life...
  25. ncbi Oral administration of RAC-alpha-lipoic acid modulates insulin sensitivity in patients with type-2 diabetes mellitus: a placebo-controlled pilot trial
    S Jacob
    Hypertension and Diabetes Research Unit, Max Grundig Clinic, Bühl and City Hospital, Baden Baden, Germany
    Free Radic Biol Med 27:309-14. 1999
    ..The results suggest that oral administration of alpha-lipoic acid can improve insulin sensitivity in patients with type-2 diabetes. The encouraging findings of this pilot trial need to be substantiated by further investigations...
  26. pmc Lipoic acid synthesis and attachment in yeast mitochondria
    Melissa S Schonauer
    Department of Biochemistry, University of Arizona, Tucson, Arizona 85721, USA
    J Biol Chem 284:23234-42. 2009
    ..We propose a model for protein lipoylation in which Lip2, Lip3, Lip5, and Gcv3 function in a complex, which may be regulated by the availability of acetyl-CoA, and which in turn may regulate mitochondrial gene expression...
  27. ncbi Lipoic acid - the drug of the future?
    Anna Bilska
    Institute of Medical Biochemistry, Medical College, Jagiellonian University, Kopernika 7, PL 31 034 Kraków, Poland
    Pharmacol Rep 57:570-7. 2005
    ..Moreover, analysis of literature data suggests participation of lipoic acid in processes of cell growth and differentiation. This fact can be crucial to clinical practice, however, this problem requires further studies...
  28. ncbi Reactive oxygen species mediate caspase activation and apoptosis induced by lipoic acid in human lung epithelial cancer cells through Bcl-2 down-regulation
    Jirapan Moungjaroen
    West Virginia University, Department of Pharmaceutical Sciences, Morgantown, WV 26506, USA
    J Pharmacol Exp Ther 319:1062-9. 2006
    ..Together, our findings indicate a novel pro-oxidant role of LA in apoptosis induction and its regulation by Bcl-2, which may be exploited for the treatment of cancer and related apoptosis disorders...
  29. pmc Alpha-lipoic acid attenuates LPS-induced inflammatory responses by activating the phosphoinositide 3-kinase/Akt signaling pathway
    Wei Jian Zhang
    Linus Pauling Institute, Oregon State University, 571 Weniger Hall, Corvallis, OR 97331 6512
    Proc Natl Acad Sci U S A 104:4077-82. 2007
    ..Lipoic acid may be useful in the prevention of sepsis and inflammatory vascular diseases...
  30. ncbi Alpha-lipoic acid increases insulin sensitivity by activating AMPK in skeletal muscle
    Woo Je Lee
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Ulsan College of Medicine, Seoul, Republic of Korea
    Biochem Biophys Res Commun 332:885-91. 2005
    ..These results suggest that ALA-induced improvement of insulin sensitivity is mediated by activation of AMPK and reduced triglyceride accumulation in skeletal muscle...
  31. ncbi Protective effect of lipoic acid on oxidative and peroxidative damage in cyclosporine A-induced renal toxicity
    Ganapathy Amudha
    Department of Medical Biochemistry, Dr ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai, 600 113, India
    Int Immunopharmacol 7:1442-9. 2007
    ..These results indicate that the antioxidant LA might have a protective effect against CsA-induced peroxidative changes and cellular damage of the renal tissue of the rat...
  32. ncbi Lipoic acid and N-acetyl cysteine decrease mitochondrial-related oxidative stress in Alzheimer disease patient fibroblasts
    Paula I Moreira
    Center for Neuroscience and Cell Biology, University of Coimbra, 3004 517 Coimbra, Portugal
    J Alzheimers Dis 12:195-206. 2007
    ..These data suggest mitochondria are important in oxidative damage that occurs in AD. As such, antioxidant therapies based on lipoic acid and N-acetyl cysteine supplementation may be promising...
  33. ncbi Biological actions of lipoic acid associated with sulfane sulfur metabolism
    Anna Bilska
    The Chair of Medical Biochemistry, Jagiellonian University, Collegium Medicum, Kopernika 7, PL 31 034 Kraków, Poland
    Pharmacol Rep 60:225-32. 2008
    ..It demonstrated for the first time in vivo that biological activity of lipoate might be connected with anaerobic cysteine metabolism to S(*) and with rhodanese activity...
  34. pmc Age-associated mitochondrial oxidative decay: improvement of carnitine acetyltransferase substrate-binding affinity and activity in brain by feeding old rats acetyl-L- carnitine and/or R-alpha -lipoic acid
    Jiankang Liu
    Division of Biochemistry and Molecular Biology, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 99:1876-81. 2002
    ..Thus, feeding old rats high levels of key mitochondrial metabolites can ameliorate oxidative damage, enzyme activity, substrate-binding affinity, and mitochondrial dysfunction...
  35. pmc Lipoic acid metabolism in Escherichia coli: the lplA and lipB genes define redundant pathways for ligation of lipoyl groups to apoprotein
    T W Morris
    Department of Microbiology, University of Illinois at Urbana Champaign 61801
    J Bacteriol 177:1-10. 1995
    ..These results support a two-pathway/two-ligase model of lipoate metabolism in E. coli...
  36. ncbi Antioxidant and prooxidant activities of alpha-lipoic acid and dihydrolipoic acid
    Hadi Moini
    Department of Applied Chemistry and Microbiology, PB 56 Viikki Biocenter, FIN 00014, University of Helsinki, Helsinki, Finland
    Toxicol Appl Pharmacol 182:84-90. 2002
    ..Whether alpha-lipoic acid and/or dihydrolipoic acid-induced oxidative protein modifications contribute to their versatile effects observed in vivo warrants further investigation...
  37. ncbi Anti-apoptotic and neuroprotective effects of α-lipoic acid on spinal cord ischemia-reperfusion injury in rabbits
    Hakan Emmez
    Department of Neurosurgery, Faculty of Medicine, Gazi University, Polikliniği Kat 1, Ankara 06500, Turkey
    Acta Neurochir (Wien) 152:1591-600; discussion 1600-1. 2010
    ..The aim of this study is to investigate the neuroprotective and anti-apoptotic effects of alpha-lipoic acid on spinal cord ischemia-reperfusion...
  38. ncbi Chronic dietary alpha-lipoic acid reduces deficits in hippocampal memory of aged Tg2576 mice
    Joseph F Quinn
    Portland Veterans Affairs Medical Center, P3 R and D Portland, OR, United States
    Neurobiol Aging 28:213-25. 2007
    ..These data indicate that chronic dietary ALA can reduce hippocampal-dependent memory deficits of Tg2576 mice without affecting beta-amyloid levels or plaque deposition...
  39. ncbi Lipoic acid and vitamin C potentiate nitric oxide synthesis in human aortic endothelial cells independently of cellular glutathione status
    Francesco Visioli
    Linus Pauling Institute, Oregon State University, Corvallis, Oregon, USA
    Redox Rep 7:223-7. 2002
    ..Thus, vitamin C and lipoic acid potentiate endothelial NO synthesis and bioactivity by mechanisms that appear to be independent of cellular GSH levels and redox environment...
  40. ncbi The contributions of antioxidant activity of lipoic acid in reducing neurogenerative progression of Parkinson's disease: a review
    Dayane Pessoa De Araújo
    Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceara, Brazil
    Int J Neurosci 121:51-7. 2011
    ..Therefore, this antioxidant has been used in the treatment of many diseases, including a new perspective for the treatment of Parkinson's disease...
  41. ncbi Alpha-lipoic acid-induced heme oxygenase-1 expression is mediated by nuclear factor erythroid 2-related factor 2 and p38 mitogen-activated protein kinase in human monocytic cells
    Richard M Ogborne
    MRC Human Nutrition Research, Elsie Widdowson Laboratory, Cambridge, CB1 9NL, UK
    Arterioscler Thromb Vasc Biol 25:2100-5. 2005
    ..This study examined the effects of ALA on HO-1 expression in human monocytic cells...
  42. ncbi Burning mouth syndrome (BMS): controlled open trial of the efficacy of alpha-lipoic acid (thioctic acid) on symptomatology
    F Femiano
    Stomatology Clinic II, University of Medicine and Surgery, Napoli, Italy
    Oral Dis 6:274-7. 2000
    Alpha-lipoic acid (ALA), is a potent antioxidant mitochondrial coenzyme, the trometamol salt of thioctic acid that has been shown in clinical studies to be neuroprotective...
  43. ncbi Protective effect of α-lipoic acid on oxidized low density lipoprotein-induced human umbilical vein endothelial cell injury
    Yan Xia Liu
    Department of Clinical Pharmacology, College of Pharmacy, Dalian Medical University, 9 west section, Lvshun South Road, Lvshunkou District, Dalian 116044, Liaoning Province, China
    Pharmacol Rep 63:1180-8. 2011
    ..The cytoprotective effects are not thought to be due to inhibited C-reactive protein (CRP) protein expression in HUVECs...
  44. pmc Acute reversal of endothelial dysfunction in the elderly after antioxidant consumption
    D Walter Wray
    Geriatric Research, Education, and Clinical Center, Salt Lake City Veterans Affairs Medical Center, Salt Lake City, UT 84132, USA
    Hypertension 59:818-24. 2012
    ....
  45. pmc Cap-independent Nrf2 translation is part of a lipoic acid-stimulated detoxification stress response
    Kate Petersen Shay
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    Biochim Biophys Acta 1823:1102-9. 2012
    ..Thus, translational control of Nrf2 synthesis, rather than reliance solely on pre-existing protein, may mediate the rapid burst of Nrf2 nuclear accumulation following stress stimuli...
  46. ncbi Thioctic acid and acetyl-L-carnitine in the treatment of sciatic pain caused by a herniated disc: a randomized, double-blind, comparative study
    Antonio Memeo
    Ortopedia Pediatrica, Istituto Ortopedico Gaetano Pini, Milan, Italy
    Clin Drug Investig 28:495-500. 2008
    ..b>Thioctic acid, a key compound in oxidative metabolism, has antioxidant properties that may help the recovery of nerve ..
  47. ncbi The impact of lipoic acid on endothelial function and proteinuria in quinapril-treated diabetic patients with stage I hypertension: results from the QUALITY study
    Syed T Rahman
    Emory University School of Medicine, Division of Cardiology, Atlanta, GA, USA
    J Cardiovasc Pharmacol Ther 17:139-45. 2012
    ....
  48. ncbi Thioredoxin and dihydrolipoic acid are required for 3-mercaptopyruvate sulfurtransferase to produce hydrogen sulfide
    Yoshinori Mikami
    Department of Molecular Pharmacology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Ogawa Higashi, Kodaira, Tokyo, Japan
    Biochem J 439:479-85. 2011
    ..We also show that 3MST produces H2S from thiosulfate. The present study provides a new insight into a mechanism for the production of H2S by 3MST...
  49. ncbi Lipoic acid administration prevents nonalcoholic steatosis linked to long-term high-fat feeding by modulating mitochondrial function
    M Pilar Valdecantos
    Department of Nutrition, Food Science, Physiology and Toxicology, University of Navarra, 31008 Pamplona, Spain
    J Nutr Biochem 23:1676-84. 2012
    ..The reduction in mitochondrial energy efficiency could also explain, at least in part, the beneficial effects of lipoic acid not only in fatty liver but also in preventing excessive body weight gain...
  50. ncbi Lipoic acid improves mitochondrial function in nonalcoholic steatosis through the stimulation of sirtuin 1 and sirtuin 3
    M Pilar Valdecantos
    Department of Nutrition, Food Science, Physiology and Toxicology, University of Navarra, Pamplona, Spain
    Obesity (Silver Spring) 20:1974-83. 2012
    ....
  51. ncbi Evaluation of anti-oxidant treatments in an in vitro model of alkaptonuric ochronosis
    Daniela Braconi
    Dipartimento di Biologia Molecolare, Universita degli Studi di Siena, Via Fiorentina 1, 53100 Siena, Italy
    Rheumatology (Oxford) 49:1975-83. 2010
    ....
  52. ncbi Antioxidant properties of an endogenous thiol: Alpha-lipoic acid, useful in the prevention of cardiovascular diseases
    Stéliana Ghibu
    University Cluj Napoca, Romania
    J Cardiovasc Pharmacol 54:391-8. 2009
    ..A more complete understanding of cellular biochemical events that influence oxidative damage is required to guide future therapeutic advances...
  53. ncbi Efficacy of DL-alpha lipoic acid against systemic inflammation-induced mice: antioxidant defense system
    E Philip Jesudason
    Bio organic and Neurochemistry Laboratory, Central Leather Research Institute, Adyar, Chennai 600 020, India
    Mol Cell Biochem 313:113-23. 2008
    ....
  54. ncbi alpha-lipoic acid inhibits endotoxin-stimulated expression of iNOS and nitric oxide independent of the heat shock response in RAW 264.7 cells
    Vincent G Demarco
    Department of Child Health, University of Missouri, Columbia, MO 65211, USA
    Free Radic Res 38:675-82. 2004
    ..Likewise, no effect of LA on HSF-1 protein expression was detected. These data suggest that LA inhibits LPS-induced activation of iNOS in macrophages independent of the heat shock response...
  55. ncbi The comparison of antioxidant and hematological properties of N-acetylcysteine and alpha-lipoic acid in physically active males
    A Zembron-Lacny
    University of Physical Education Poznan, Faculty of Physical Culture Gorzow Wlkp, Department of Biochemistry, Gorzow Wlkp, Poland
    Physiol Res 58:855-61. 2009
    ..Our study has shown that both N-acetylcysteine and alpha-lipoic acid intake reveal an antioxidant action, but only N-acetylcysteine improves the haematological response...
  56. ncbi Dietary lipoic acid-dependent changes in the activity and mRNA levels of hepatic lipogenic enzymes in rats
    Doan Thi Thanh Huong
    Laboratory of Nutritional Function, Division of Food Function, National Food Research Institute, 2 1 12 Kannondai, Tsukuba 305 8642, Japan
    Br J Nutr 100:79-87. 2008
    ..Lipoic acid appeared to reduce hepatic lipogenesis and hence decreases serum and liver lipid levels. Alterations in serum concentrations of insulin and (or) adiponectin may trigger this consequence...
  57. ncbi The mitochondrial cocktail: rationale for combined nutraceutical therapy in mitochondrial cytopathies
    M A Tarnopolsky
    Department of Pediatrics and Medicine, McMaster University, 1200 Main St W, HSC 2H26, Hamilton, Ontario L8N3Z5, Canada
    Adv Drug Deliv Rev 60:1561-7. 2008
    ....
  58. ncbi Alpha lipoic acid protects heart against myocardial ischemia-reperfusion injury through a mechanism involving aldehyde dehydrogenase 2 activation
    Lan He
    Department of Pharmacology, School of Pharmaceutical Sciences, Central South University, Changsha 410078, China
    Eur J Pharmacol 678:32-8. 2012
    ..The regulatory effect of lipoic acid on ALDH2 activity is dependent on PKCε signaling pathway...
  59. ncbi Cellular mechanisms by which lipoic acid confers protection during the early stages of cerebral ischemia: a possible role for calcium
    Marc J P Richard
    Department of Biomedical Science, Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, PE, C1A 4P3, Canada
    Neurosci Res 69:299-307. 2011
    ..In summary, these findings suggest that LA does not affect neuronal physiology under normal conditions, but can protect cells from an ischemic event...
  60. ncbi Dietary alpha-lipoic acid supplementation lowers blood pressure in spontaneously hypertensive rats
    S Vasdev
    Department of Medicine, Health Sciences Centre, Memorial University of Newfoundland, St John s, Canada
    J Hypertens 18:567-73. 2000
    ....
  61. ncbi R-alpha-lipoic acid action on cell redox status, the insulin receptor, and glucose uptake in 3T3-L1 adipocytes
    Hadi Moini
    Department of Molecular Pharmacology and Toxicology, School of Pharmacy, University of Southern California, Los Angeles, California 90033, USA
    Arch Biochem Biophys 397:384-91. 2002
    ....
  62. pmc A novel amidotransferase required for lipoic acid cofactor assembly in Bacillus subtilis
    Quin H Christensen
    Departments of Microbiology Biochemistry Chemistry Biology Interface Training Program, University of Illinois, Urbana, IL 61801, USA
    Mol Microbiol 80:350-63. 2011
    ..Thus, these two homologous enzymes have convergent architectures...
  63. ncbi The effect of alpha-lipoic acid on symptoms and skin blood flow in diabetic neuropathy
    H Y Jin
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Chonbuk National University, Medical School, Jeon Ju, South Korea
    Diabet Med 24:1034-8. 2007
    ..The aim of this study was to assess the effect of alpha-lipoic acid on skin blood flow in patients with diabetic neuropathy...
  64. ncbi Long-term safety of alpha-lipoic acid (ALA) consumption: A 2-year study
    D R Cremer
    Degussa Food Ingredients GmbH, Lise Meitnerstr 34 D 85354 Freising, Germany
    Regul Toxicol Pharmacol 46:193-201. 2006
    Alpha-lipoic acid (ALA) (CAS RN 1077-28-7), also referred to as thioctic acid, has been demonstrated to exhibit strong anti-oxidant properties...
  65. ncbi Alpha lipoic acid: a new treatment for neuropathic pain in patients with diabetes?
    G S Mijnhout
    Department of Internal Medicine, Isala Clinics, Zwolle, The Netherlands
    Neth J Med 68:158-62. 2010
    ..Neuropathic pain is difficult to treat. We identified those studies in the literature in which the effectiveness of alpha lipoic acid as a treatment for neuropathic pain was evaluated...
  66. ncbi Heme oxygenase-1 contributes to the cytoprotection of alpha-lipoic acid via activation of p44/42 mitogen-activated protein kinase in vascular smooth muscle cells
    Pao Yun Cheng
    Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan
    Free Radic Biol Med 40:1313-22. 2006
    ..This study demonstrated that ALA increases the expression of HO-1, a critical cytoprotective molecule, and identified a novel pleiotropic effect of ALA on cardiovascular protection...
  67. ncbi Burning mouth syndrome (BMS): double blind controlled study of alpha-lipoic acid (thioctic acid) therapy
    F Femiano
    Stomatology Clinic II, University of Medicine and Surgery, Napoli, Italy
    J Oral Pathol Med 31:267-9. 2002
    ..Alpha-lipoic acid is an antioxidant able to increase the levels of intracellular glutathione and eliminate free radicals. This study aimed to examine the effectiveness of alpha-lipoic acid in the therapy of BMS...
  68. ncbi Effect of DL-alpha-lipoic acid on the status of lipid peroxidation and antioxidant enzymes in various brain regions of aged rats
    P Arivazhagan
    Department of Medical Biochemistry, Dr AL Mudaliar Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai 600 113, India
    Exp Gerontol 37:803-11. 2002
    ....
  69. ncbi Effects of alpha-lipoic Acid on body weight in obese subjects
    Eun Hee Koh
    Department of Internal Medicine, University of Ulsan College of Medicine, Seoul, Republic of Korea
    Am J Med 124:85.e1-8. 2011
    ..We previously reported that alpha-lipoic acid markedly reduced body weight gain in rodents. The purpose of this study was to determine whether alpha-lipoic acid reduces body weight in obese human subjects...
  70. ncbi Pro-oxidant actions of alpha-lipoic acid and dihydrolipoic acid
    Ufuk Cakatay
    Istanbul University, Istanbul Faculty of Medicine, Central Laboratory of Biochemistry, Capa 34390, Istanbul, Turkey
    Med Hypotheses 66:110-7. 2006
    ..This aspect remains to be elucidated. In further studies, careful evaluation will be necessary for the decision in the biological system whether LA administration is beneficial or harmful...
  71. ncbi Alpha-lipoic acid improves vascular endothelial function in patients with type 2 diabetes: a placebo-controlled randomized trial
    B B Heinisch
    Medical University of Vienna, Vienna, Austria
    Eur J Clin Invest 40:148-54. 2010
    ..The aim of this study was to investigate the effect of alpha-lipoic acid (ALA) treatment on endothelium-dependent and -independent vasodilatation, assessed by forearm blood flow (FBF), in patients with type 2 diabetes mellitus...
  72. ncbi The potential protective role of alpha-lipoic acid against acetaminophen-induced hepatic and renal damage
    Ahmed O Abdel-Zaher
    Department of Pharmacolog, Faculty of Medicine, Assiut University, Assiut, Egypt
    Toxicology 243:261-70. 2008
    ..These results provide evidence that inhibition of NO overproduction and maintenance of intracellular antioxidant status may play a pivotal role in the protective effects of alpha-LA against APAP-induced hepatic and renal damage...
  73. ncbi Alpha-lipoic acid preconditioning reduces ischemia-reperfusion injury of the rat liver via the PI3-kinase/Akt pathway
    Christian Muller
    Dept of Pharmacy, Center of Drug Research, Univ of Munich, Germany
    Am J Physiol Gastrointest Liver Physiol 285:G769-78. 2003
    ..This study shows for the first time that the PI3-kinase/Akt pathway plays a central protective role in IRI of the rat liver and that LA administration attenuates IRI via this pathway...
  74. ncbi Alpha-lipoic acid: a multifunctional antioxidant that improves insulin sensitivity in patients with type 2 diabetes
    J L Evans
    Medical Research Institute, San Bruno, California 94066, USA
    Diabetes Technol Ther 2:401-13. 2000
    ..If the limitations of oral therapy can be overcome, LA could emerge as a safe and effective adjunctive antidiabetic agent with insulin sensitizing activity...
  75. ncbi Mitochondrial fatty acid synthesis and respiration
    J Kalervo Hiltunen
    Department of Biochemistry and Biocenter Oulu, University of Oulu, PO Box 3000, FI 90014 Oulu, Finland
    Biochim Biophys Acta 1797:1195-202. 2010
    ..The linkage of FAS II genes to published animal models for human disease supports the hypothesis that mitochondrial FAS dysfunction leads to the development of disorders in mammals...
  76. ncbi The effects and mechanisms of mitochondrial nutrient alpha-lipoic acid on improving age-associated mitochondrial and cognitive dysfunction: an overview
    Jiankang Liu
    Institute for Brain Aging and Dementia, University of California, 1261 Gillespie Neuroscience Research Facility, Irvine, CA 92697, USA
    Neurochem Res 33:194-203. 2008
    ....
  77. ncbi Improvement of insulin sensitivity in patients with type 2 diabetes mellitus after oral administration of alpha-lipoic acid
    Petya Kamenova
    Department of Diabetology, University Hospital of Endocrinology, Medical University, Sofia, Bulgaria
    Hormones (Athens) 5:251-8. 2006
    ..Amelioration of insulin resistance could improve both glycaemic control and cardiovascular risk factors in patients with type 2 diabetes mellitus. Alpha-lipoic acid has been shown to improve insulin action after parenteral administration...
  78. ncbi Increased ROS generation and p53 activation in alpha-lipoic acid-induced apoptosis of hepatoma cells
    G Simbula
    Department of Toxicology, Oncology and Molecular Pathology Unit, Italy
    Apoptosis 12:113-23. 2007
    ..In conclusion, this study provides evidence that alpha-LA induces apoptosis in hepatoma cells, describes a possible sequence of molecular events underlying its lethal effect, and suggests that it may prove useful in liver cancer therapy...
  79. ncbi Treatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid: a meta-analysis
    D Ziegler
    German Diabetes Research Institute, Leibriz Institute at the Heinrich Heine University, Dusseldorf, Germany
    Diabet Med 21:114-21. 2004
    ..To determine the efficacy and safety of 600 mg of alpha-lipoic acid given intravenously over 3 weeks in diabetic patients with symptomatic polyneuropathy...
  80. ncbi The antihyperglycemic drug alpha-lipoic acid stimulates glucose uptake via both GLUT4 translocation and GLUT4 activation: potential role of p38 mitogen-activated protein kinase in GLUT4 activation
    D Konrad
    Programme in Cell Biology, The Hospital for Sick Children, 555 University Ave, Toronto, Ontario, M5G 1X8, Canada
    Diabetes 50:1464-71. 2001
    ..Instead, it is likely that regulation of transporter activity is sensitive to these inhibitors...
  81. ncbi Attenuation of myocardial apoptosis by alpha-lipoic acid through suppression of mitochondrial oxidative stress to reduce diabetic cardiomyopathy
    Chun jun Li
    The Ministry of Health Key Laboratory of Hormone and Development, Department of Endocrinology, Metabolic Disease Hospital of Tianjin Medical University, Tianjin 300070, China
    Chin Med J (Engl) 122:2580-6. 2009
    ..This study aimed to test whether the antioxidant alpha-lipoic acid (alpha-LA) could attenuate mitochondrion-dependent myocardial apoptosis through suppression of mitochondrial oxidative stress to reduce diabetic cardiomyopathy...
  82. ncbi Thioctic acid for patients with symptomatic diabetic polyneuropathy: a critical review
    Dan Ziegler
    German Diabetes Clinic, German Diabetes Research Institute, Leibniz Institute at the Heinrich Heine University, Dusseldorf, Germany
    Treat Endocrinol 3:173-89. 2004
    ..diabetic neuropathy, oxygen free-radical activity in the sciatic nerve is increased, and treatment with thioctic acid, a potent lipophilic antioxidant, results in prevention or improvement of the diabetes-induced neurovascular ..
  83. ncbi Is alpha-lipoic acid a scavenger of reactive oxygen species in vivo? Evidence for its initiation of stress signaling pathways that promote endogenous antioxidant capacity
    Kate Petersen Shay
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    IUBMB Life 60:362-7. 2008
    ..This would promote a sustained improvement in cellular resistance to pathologies where oxidative stress is involved, which would not be forthcoming if LA solely acted as a transient ROS scavenger...
  84. ncbi The plasma pharmacokinetics of R-(+)-lipoic acid administered as sodium R-(+)-lipoate to healthy human subjects
    David A Carlson
    GeroNova Research, Inc, 4677 Meade St, Richmond, California 94804, USA
    Altern Med Rev 12:343-51. 2007
    ..Rac-LA and the natural form, R-lipoic acid (RLA), are widely available as nutritional supplements, marketed as antioxidants. Rac-LA sodium salt (NaLA) or rac-LA potassium salt (KLA) has been used to improve the aqueous solubility of LA...
  85. pmc Lipoic acid effects on established atherosclerosis
    Zhekang Ying
    Davis Heart Lung Research Institute, College of Medicine, and Division of Environmental Health Sciences, College of Public Health, The Ohio State University, Columbus, Ohio 43210 1252, USA
    Life Sci 86:95-102. 2010
    ..We investigated the mechanisms by which LA may confer protection in models of established atherosclerosis...
  86. ncbi Evidence that α-lipoic acid inhibits NF-κB activation independent of its antioxidant function
    Zhekang Ying
    Davis Heart and Lung Research Institute, Colleges of Medicine and Public Health, The Ohio State University, Room 110, 473W 12th Avenue, Columbus, OH 43210 1252, USA
    Inflamm Res 60:219-25. 2011
    ..It is postulated that the anti-inflammatory function of LA results from its antioxidant function. In this study we tested whether inhibition of NF-κB by LA is dependent on its antioxidant function...
  87. ncbi New metabolic pathways of alpha-lipoic acid
    H Schupke
    Department of Metabolism and Development, elbion AG, Radebeul, Germany
    Drug Metab Dispos 29:855-62. 2001
    ..Furthermore, new data are presented that suggest conjugation with glycine occurred as a separate metabolic pathway in competition with beta-oxidation, predominantly in mice...
  88. ncbi Distribution study of orally administered lipoic acid in rat brain tissues
    H T Chng
    Department of Pharmacy, Faculty of Science, National University of Singapore, 18 Science Drive 4, 117543 Singapore
    Brain Res 1251:80-6. 2009
    ..01, respectively. Our results demonstrate for the first time that LA does not cross the blood-brain barrier readily and suggest that the antioxidant effect of LA in brain may not be due to its direct effect in the central nervous system...
  89. ncbi The natural antioxidant alpha-lipoic acid induces p27(Kip1)-dependent cell cycle arrest and apoptosis in MCF-7 human breast cancer cells
    Elena Dozio
    Department of Human Morphology and Biomedical Sciences Citta Studi, Via L Mangiagalli 31, Universita degli Studi di Milano, Milan, Italy
    Eur J Pharmacol 641:29-34. 2010
    ..Thus, the anti-tumor activity of alpha-lipoic acid observed in MCF-7 cells further stresses the role of redox state in regulating cancer initiation and progression...
  90. ncbi A randomized double-blind placebo-controlled trial of thioctic acid in migraine prophylaxis
    Delphine Magis
    Headache Research Unit, Neurology Department, University of Liege, Liege, Belgium
    Headache 47:52-7. 2007
    ..b>Thioctic acid (-lipoic acid) is another substance known to enhance energy metabolism in mitochondria and to be beneficial in ..
  91. ncbi Ca2+/calmodulin-dependent protein kinase kinase is involved in AMP-activated protein kinase activation by alpha-lipoic acid in C2C12 myotubes
    Qingwu W Shen
    Department of Animal Science, Interdepartmental Molecular and Cellular Life Science Program, University of Wyoming, Laramie, WY 82071, USA
    Am J Physiol Cell Physiol 293:C1395-403. 2007
    ..These data show that CaMKK is the kinase responsible for ALA-induced AMPK activation in C2C12 myotubes...
  92. ncbi Antiplatelet activity of alpha-lipoic acid
    Yuan Shu Lai
    Taipei City Hospital, Taipei, Taiwan
    J Agric Food Chem 58:8596-603. 2010
    ..Moreover, inhibition of ROS formation and increase of platelet membrane fluidity may also involve its actions...
  93. ncbi [Effects of α-lipoic acid and vitamin C on oxidative stress in rat exposed to chronic arsenic toxicity]
    Chong bin Liu
    Institute of Nutrition and Health Ecology, School of Basic Medicine, Wenzhou Medical College, Wenzhou 325035, China
    Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 28:891-4. 2010
    ..To explore arsenic-induced oxidative stress and the protective efficacy of α-lipoic acid and vitamin c...
  94. ncbi Alpha-lipoic acid rebalances redox and immune-testicular milieu in septic rats
    Abdelkader E Ashour
    Department of Pharmacology and Toxicology, King Saud University, Riyadh, Saudi Arabia
    Chem Biol Interact 189:198-205. 2011
    ..Pretreatment with ALA ameliorated all these effects by its immune-modulator and antioxidant mechanisms suggesting a protective role against male infertility in septic or severely infected patients...
  95. ncbi Alpha-lipoic acid prevents lipotoxic cardiomyopathy in acyl CoA-synthase transgenic mice
    Young Lee
    Gifford Laboratories, Touchstone Center for Diabetes Research, University of Texas, Southwestern Medical Center, Dallas, TX 75390 8854, USA
    Biochem Biophys Res Commun 344:446-52. 2006
    ..Since food restriction did not prevent lipotoxicity, we conclude that alpha-LA treatment, like hyperleptinemia, protects the heart of ACS-transgenic mice from lipotoxicity...
  96. ncbi Effect of alpha-lipoic acid on visual evoked potentials in rats exposed to sulfite
    Narin Derin
    Department of Biophysics, Akdeniz University School of Medicine, 07070 Antalya, Turkey
    Neurotoxicol Teratol 31:34-9. 2009
    ..Though not significant, a similar increase in GSH:GSSG ratio was also observed in the retina of SL group. This study showed that LA is protective against sulfite-induced VEP alterations and oxidative stress in the brain and retina...
  97. ncbi Intervention of alpha-lipoic acid ameliorates methotrexate-induced oxidative stress and genotoxicity: A study in rat intestine
    V P Dadhania
    Johnson and Johnson Limited, L B S Marg, Mulund W, Mumbai 400080, India
    Chem Biol Interact 183:85-97. 2010
    ....
  98. ncbi Dietary lipoic acid supplementation attenuates hypertension in Dahl salt sensitive rats
    Sudesh Vasdev
    Department of Medicine, Room H 4310, Health Sciences Centre, Memorial University of Newfoundland, St John s, Newfoundland, Canada
    Mol Cell Biochem 275:135-41. 2005
    ..Dietary lipoic acid supplementation attenuated the increase in systolic blood pressure and associated biochemical and histopathological changes...
  99. ncbi Lipid stability and antioxidant profile of microsomal fraction of broiler meat enriched with α-lipoic acid and α-tocopherol acetate
    Muhammad S Arshad
    National Institute of Food Science and Technology, Faisalabad, Pakistan
    J Agric Food Chem 59:7346-52. 2011
    ..63 ± 0.008 μg/mg of protein), in which the only oxidized oil was used. Oxidized oil in feed reduced weight gain and increased TBARS, whereas TPC, DPPH, ALA, and ATA values decreased in both leg and breast meat...
  100. ncbi Protective effect of acetyl-l-carnitine and α-lipoic acid against the acute toxicity of diepoxybutane to human lymphocytes
    Filipa Ponte
    REQUIMTE, Laboratory of Toxicology, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Rua Anibal Cunha, 164, 4099 030 Porto, Portugal
    Toxicology 289:52-8. 2011
    ....
  101. ncbi Lipoic acid stimulates cAMP production in T lymphocytes and NK cells
    R V Schillace
    Portland Veterans Affairs Medical Center and Department of Neurology, Oregon Health and Science University, Portland, OR 97239, USA
    Biochem Biophys Res Commun 354:259-64. 2007
    ..This novel mechanism of action is highly relevant to the immunomodulatory effects of LA and provides further support for the study of LA as a therapeutic agent for multiple sclerosis and other autoimmune diseases...

Research Grants62

  1. Prevention of Complications in Thalassemia
    Elliott P Vichinsky; Fiscal Year: 2011
    ..Ourmissionalsoincludesmonitorinbgloodsafety amongtransfusion-dependtehnatlassemipaatientsa,ndprovidingoutreachand educationservicestoallat-riskpopulationtshroughoutht estate. ..
  2. Dose Ranging study of the Effects of Alpha Acid on Oxidative Stress
    Pamela Ouyang; Fiscal Year: 2010
    ..This study will determine the effective dose that should be studied in future larger studies powered to evaluate whether alpha lipoic acid therapy improves vascular function. ..
  3. Anti-Inflammatory Interventions in Maintenance Hemodialysis Patients
    Talat Alp Ikizler; Fiscal Year: 2013
    ....
  4. Alpha Lipoic Acid Derivatives for Treatment of Hypertension
    DESIKAN RAJAGOPAL; Fiscal Year: 2010
    ..The outcomes of this study will help to further advance the commercial development of such molecules. ..
  5. Multifunctional PEG Hydrogel Nano/Microparticles for Targeted Treatment of NSCLC
    Patrick J Sinko; Fiscal Year: 2013
    ....
  6. Suppression of Mutagenesis with Antioxidants
    WILFREDO HERNANDEZ; Fiscal Year: 2012
    ..We will test the protection against mutations and DNA damage, which is a precursor to mutations. If antioxidants work, they may be used to reduce risk of cancer and other diseases typical of old age. ..
  7. RICKETTSIA RICKETTSII IN HUMAN ENDOTHELIAL CELLS
    David Silverman; Fiscal Year: 2002
    ....
  8. REACTIVE NITROGEN & CEREBRAL ISCHEMIC INJURY
    MUSH KHAN; Fiscal Year: 2003
    ....
  9. VASCULAR DISEASE IN DIABETIC NEUROPATHY
    Mark Yorek; Fiscal Year: 2003
    ..In summary, these studies will provide us with a better understanding of the etiology of DN and improved treatments for preventing the diabetes-induced changes in vascular and neural function. ..
  10. Painful HIV Neuropathy: Treatment with Alpha-Lipoic Acid
    J Mann; Fiscal Year: 2004
    ..Possible benefits of the study to patients with HIV-associated painful neuropathy include reduction in pain and disability, reduced use of medications and enhanced cellular metabolism. ..
  11. THERAPEUTIC ROLE OF ANTIOXIDANTS IN LEAD POISONING
    Nuran Ercal; Fiscal Year: 2000
    ..In addition, the proposal may offer insights into our understanding of the mechanisms of enantiomeric selectivity of thiols in general. ..
  12. Oxidant Stress and Antioxidants during HIV Therapy
    Todd Hulgan; Fiscal Year: 2007
    ..The candidate's long-term goal is to develop into an independent clinical investigator in this field of study. ..
  13. GLOBOID CELL LEUKODYSTROPHY
    Avtar Singh; Fiscal Year: 2005
    ....
  14. MINORITY PREDOCTORAL FELLOWSHIP PROGRAM
    NATASHA NESBITT; Fiscal Year: 2005
    Lipoic acid, 6,8,-thioctic acid, is a key component of many multienzyme complexes that are essential in primary metabolism. It is found in most prokaryotes and eukaryotes as well as plant and animal tissue...
  15. Lipoic Acid and Insulin Resistance
    Ira Goldfine; Fiscal Year: 2009
    ....
  16. Targeting Antioxidant Therapy to Cardiac Mitochondria
    EVAN ABEL; Fiscal Year: 2006
    ..Once efficacy is determined, promising reagents can then be subjected to pharmacokinetic and toxicological analysis following systemic administration. ..
  17. SBIR TOPIC NCCAM: 001 R AND RS-ALPHA-LIPOIC ACID ANALYTICAL METHODS VALIDATION
    Deanna Nelson; Fiscal Year: 2011
    ..abstract_text> ..
  18. Fish oil & alpha lipoic acid in mild Alzheimer's disease
    Lynne Shinto; Fiscal Year: 2004
    ..Compliance of fish oil supplementation will be assessed by red blood cell membrane fatty acid analysis. ..
  19. Immune restoration by lipoic acid in AIDS
    RAXIT JARIWALLA; Fiscal Year: 2002
    ..The proposed research will show whether GSH augmentation by ALA increases CD4+ cell number and T cell function and reduces viral load in subjects unresponsive to antiretroviral therapy. ..
  20. Glycogen Synthase Kinase-3 and Muscle Insulin Resistance
    ERIK HENRIKSEN; Fiscal Year: 2007
    ..abstract_text> ..
  21. Antioxidant Functions of Lipoic Acid
    James May; Fiscal Year: 2004
    ..Despite the widespread use of lipoic acid, these studies are necessary to establish the biological basis and rationale for the clinical use of the agent. ..
  22. DELAYING MITOCHONDRIAL DECAY WITH CARNITINE AND LIPOATE
    Bruce Ames; Fiscal Year: 2001
    ..abstract_text> ..
  23. QUANTITATIVE METALLOPROTEOMICS: THE HUMAN ERYTHROCYTE
    Bruce Ames; Fiscal Year: 2006
    ..abstract_text> ..
  24. MALDI-TOF MASS SPECTROMETER
    Bruce Ames; Fiscal Year: 2002
    ..abstract_text> ..
  25. Antioxidant vitamins in models of Alzheimer's Disease
    James May; Fiscal Year: 2008
    ..If antioxidant vitamins ameliorate toxicity in cell and animal models of Alzheimer's disease, then oxidant stress is involved in disease progression, and antioxidant vitamin supplements may be beneficial. ..
  26. Lipoic Acid, Endothelial Activation and Atherosclerosis
    Weijian Zhang; Fiscal Year: 2002
    ....
  27. Mitochondrial Nutrients Protect RPE from Oxidant Damage
    Bruce Ames; Fiscal Year: 2006
    ..This in vitro analysis of mitochondrial nutrients may provide the basis for the development of therapeutic agents that can prevent and/or reduce the retinal and RPE pathophysiology observed in AMD. [unreadable] [unreadable] [unreadable]..
  28. Antioxidant Interaction of Selenium and Vitamins C & E
    James May; Fiscal Year: 2008
    ..Using this approach, it will be possible to relate the crucial, mitochondrial functions of selenium and vitamins C and E to the antioxidant defenses of the whole animal. ..
  29. DO HIGH DOSE B VITAMINS DELAY AGE-RELATED DECAY
    Bruce Ames; Fiscal Year: 2005
    ....
  30. Mitochondrial Metabiolites to Treat Parkinson's Disease
    Bruce Ames; Fiscal Year: 2005
    ..This project on PD is a new direction for our work on preventing mitochondrial decay and could lead to an effective and cost efficient prevention /therapy for PD. ..
  31. PLACENTAL VITAMIN TRANSPORT-MOLECULAR & CELLULAR ASPECTS
    Puttur Prasad; Fiscal Year: 2003
    ..Proposed studies will also investigate the regulation of SVCT2 expression in rat placenta and BeWo cells in response to substrate availability and ontogenic development of SVCT2 in rat placenta. ..
  32. Tuning-Up Human Metabolism
    Bruce Ames; Fiscal Year: 2005
    ..Previous results showed that high doses of key mitochondrial metabolites delay mitochondrial decay and involve Km. 4) Minimizing DNA damage and cancer by optimizing micronutrient levels, particularly in the elderly. ..
  33. Metalloproteome of the Aging Rat Brain Mitochondria
    Bruce Ames; Fiscal Year: 2007
    ..Thus, this work has significant potential to integrate numerous aspects of mitochondrial metabolism and physiology and reveal novel opportunities for combating aging-related decline. [unreadable] [unreadable] [unreadable]..
  34. EPIGALLOCATECHIN GALLATE AS A NEUROPROTECTANT IN A MODEL OF MULTIPLE SCLEROSIS
    Gail Marracci; Fiscal Year: 2007
    ..The purpose of this research is to provide the groundwork necessary to develop EGCG as a novel neuroprotective treatment for the human disease, multiple sclerosis. ..
  35. Can dynamic pupillography and/or spectral analysis of heart rate variability prov
    Solomon Tesfaye; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  36. Taurine and Painful Diabetic Neuropathy
    Martin Stevens; Fiscal Year: 2007
    ..These studies will test a novel mechanistically based therapeutic approach to a common disabling and often-refractory complication of diabetes. ..
  37. DYSREGULATION OF THE TAURINE TRANSPORTER IN DIABETES
    Martin Stevens; Fiscal Year: 2002
    ..As an alternative, if in aim 1 little correlation between hTT mRNA abundance and hTT activity is found, then glucose mediated post-translational modifications will be examined. ..
  38. Use of host derived lipoate by Listeria monocytogenes
    MARY O RIORDAN; Fiscal Year: 2009
    ..In addition, the characterization of Lm mutants that are defective in intracellular growth will provide new candidates for live vaccine development and may identify new targets for anti-microbial therapeutics. ..
  39. Retinal Oxygenation in Diabetic Retinopathy
    BRUCE BERKOWITZ; Fiscal Year: 2004
    ..The results of these studies could lead to the development of a non-invasive real time method for the early evaluation of diabetic retinopathy and its treatment. ..
  40. Redox Control of Radiation Response
    John Biaglow; Fiscal Year: 2006
    ..Ultimately, we hope to develop specific strategies for modifying thiol redox homeostasis in vivo, to make human tumors more sensitive to ionizing radiation. ..
  41. ALUMINUM/IRON INTERACTIONS IN NEURODEGENERATIVE DISEASE
    Stephen Bondy; Fiscal Year: 2005
    ..Together, these five objectives delineate a research strategy that will allow resolution of the seemingly contradictory evidence relating aluminum to neurological degeneration. ..
  42. Adjuvant Therapy for Vascular Inflammation in Diabetes
    Sushil Jain; Fiscal Year: 2006
    ..abstract_text> ..
  43. Reducing Renal TGF-B in Diabetic Glomerulosclerosis
    MARGO COHEN; Fiscal Year: 2005
    ..abstract_text> ..
  44. AGE RELATED NEURODEGENERATIVE DISEASES IN MICRONESIA
    Douglas Galasko; Fiscal Year: 2006
    ..Subproject by Lee: 'PHF-tau in neurodegenerative diseases of Guam' will assess oxidative markers related to brain lesions in ALS, PDC and dementia. ..
  45. Evaluation of Antioxidant Suppl in Focal CNS Ischemia
    Wayne Clark; Fiscal Year: 2003
    ..The information obtained from this project will be critical in planning future clinical stroke trials involving these agents. ..
  46. North Carolina Needs Assessment for Oral Cancer Control
    Lauren Patton; Fiscal Year: 2003
    ....
  47. Point-of-Care Measurement of Glycated Hemoglobin
    MARGO COHEN; Fiscal Year: 2004
    ....
  48. Anti-Trypanosomal Agents from a Neotropical Cloudforest
    WILLIAM SETZER; Fiscal Year: 2004
    ..The long-term benefit of this research project is the development of new medicines to treat patients with Chagas disease. ..
  49. Ketosis, Vascular Inflammation and Its Therapy in Type 1 Diabetic Patients
    Sushil K Jain; Fiscal Year: 2010
    ..The long-term goal is to understand the role of ketosis in CVD and to discover a relatively low-cost dietary supplement that could be used as an adjuvant therapy for CVD prevention in type 1 diabetes. ..
  50. MECHANISM OF E. COLI PYRUVATE DEHYDROGENASE COMPLEX-E1
    Frank Jordan; Fiscal Year: 2004
    ....
  51. MR STUDIES OF EXPERIMENTAL RETINOPATHY OF PREMATURITY
    BRUCE BERKOWITZ; Fiscal Year: 2001
    ..This work may have broad impact beyond ROP since abnormal blood vessel growth is a common pathobiologic event for other blinding disorders, such as diabetic retinopathy. ..
  52. Localized Bioimpedance in Neuromuscular Disease
    SEWARD RUTKOVE; Fiscal Year: 2006
    ..As part of this aim, a prototype device for easy use will be developed and tested in the clinical setting. ..
  53. Oxidative Damage in Smokers and Passive Smokers
    Gladys Block; Fiscal Year: 2003
    ..smokers 6) To determine the level of vitamin C required by smokers to attain the plasma vitamin C levels of non-smokers 7) To study the effect of supplemental vitamin C or antioxidant cocktail on other plasma antioxidants ..
  54. Alzheimer's Disease in Down Syndrome: Antioxidant Trial
    Ira Lott; Fiscal Year: 2005
    ..The pilot trial should also contribute information as to the possible role of antioxidants in the treatment or prevention of AD in the general population. ..
  55. Manganese-enhanced MRI Studies of Retinal Neovascularization
    BRUCE BERKOWITZ; Fiscal Year: 2008
    ..The novel methods in this application will also contribute to the advancement of functional MRI for the study of retinal diseases. [unreadable] [unreadable] [unreadable]..
  56. HPLC DETECTION OF RADICAL INTERMEDIATES
    Detcho Stoyanovsky; Fiscal Year: 2002
    ..The method is expected to display several orders of magnitude higher sensitivity than then traditional ESR spin trapping technique and may be a new approach in assays of oxidative stress. ..
  57. Spanish Translation and Validation of Sleep Measures
    Carol Baldwin; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  58. Ambulatory Foot Temperature in Diabetic Neuropathy
    SEWARD RUTKOVE; Fiscal Year: 2006
    ..Ultimately, the results obtained in this work may justify the use of ambulatory foot temperature monitoring in DN clinical trials, both as a screening tool for early disease and as an outcome measure. ..
  59. Development of a Diagnostic Test for Alzheimer's Disease
    Mark Lovell; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  60. LDL Modification in Diabetic Complications
    MARGO COHEN; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  61. Neurodegenration and Mitochnodrial Dysfunction in Aging
    Stephen Bondy; Fiscal Year: 2008
    ..This is also likely to be relevant to slowing the onset of, and reducing the incidence of, several neurodegenerative diseases where age is a major co-factor. [unreadable] [unreadable]..