snake venoms

Summary

Summary: Solutions or mixtures of toxic and nontoxic substances elaborated by snake (Ophidia) salivary glands for the purpose of killing prey or disabling predators and delivered by grooved or hollow fangs. They usually contain enzymes, toxins, and other factors.

Top Publications

  1. ncbi Skeletal muscle degeneration induced by venom phospholipases A2: insights into the mechanisms of local and systemic myotoxicity
    Jose Maria Gutierrez
    Instituto Clodomiro Picado, Facultad de Microbiologia, Universidad de Costa Rica, San Jose, Costa Rica
    Toxicon 42:915-31. 2003
  2. ncbi Early evolution of the venom system in lizards and snakes
    Bryan G Fry
    Australian Venom Research Unit, Level 8, School of Medicine, University of Melbourne, Parkville, Victoria 3010, Australia
    Nature 439:584-8. 2006
  3. pmc From genome to "venome": molecular origin and evolution of the snake venom proteome inferred from phylogenetic analysis of toxin sequences and related body proteins
    Bryan G Fry
    Australian Venom Research Unit, Level 8, School of Medicine, University of Melbourne, Parkville, Victoria 3010 Australia
    Genome Res 15:403-20. 2005
  4. ncbi Chemical modifications of phospholipases A2 from snake venoms: effects on catalytic and pharmacological properties
    Andreimar M Soares
    Departamento de Biotecnologia, Universidade de Ribeirão Preto UNAERP, Ribeirão Presto, SP, Brazil
    Toxicon 42:855-68. 2003
  5. ncbi Novel transcripts in the maxillary venom glands of advanced snakes
    Bryan G Fry
    Venom Evolution Laboratory, School of Biological Sciences, University of Queensland, St Lucia, Queensland 4072, Australia
    Toxicon 59:696-708. 2012
  6. ncbi Purification and partial characterization of two phospholipases A2 from Bothrops leucurus (white-tailed-jararaca) snake venom
    D A Higuchi
    University of Mogi das Cruzes, Av Dr Candido Xavier de Almeida Souza 200, Centro Cívico, CEP 08780 911 Mogi das Cruzes, Sao Paulo, Brazil
    Biochimie 89:319-28. 2007
  7. ncbi Molding the business end of neurotoxins by diversifying evolution
    Adi Kozminsky-Atias
    Department of Life Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    FASEB J 26:576-86. 2012
  8. ncbi Excitement ahead: structure, function and mechanism of snake venom phospholipase A2 enzymes
    R Manjunatha Kini
    Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore 117543
    Toxicon 42:827-40. 2003
  9. ncbi Assembling an arsenal: origin and evolution of the snake venom proteome inferred from phylogenetic analysis of toxin sequences
    B G Fry
    Australian Venom Research Unit, Department of Pharmacology, University of Melbourne, Parkville, Australia
    Mol Biol Evol 21:870-83. 2004
  10. ncbi Snake bite
    David A Warrell
    Nuffield Department of Clinical Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Lancet 375:77-88. 2010

Research Grants

  1. Remote-control mouse-implantable micropumps for establishment of regenerative cap
    JUAN GABRIEL contact SANTIAGO; Fiscal Year: 2010
  2. 2010 Angiotensin Gordon Research Conference
    Kathy K Griendling; Fiscal Year: 2010
  3. Center for Computational Mass-Spectrometry
    Pavel A Pevzner; Fiscal Year: 2011
  4. Viper Resource Center (VRC) at Texas A&M University-Kingsville
    JOHN CARLOS PEREZ; Fiscal Year: 2013
  5. Center for Computational Mass-Spectrometry
    Pavel A Pevzner; Fiscal Year: 2013
  6. Studies on anticoagulant properties of thrombin
    Enrico Di Cera; Fiscal Year: 2013
  7. Prokineticin 2 and Neuroinflammatory Mechanisms
    Arthi Kanthasamy; Fiscal Year: 2013
  8. Center for Allaying Health Disparities Through Research and Education (CADRE)
    CYNTHIA JACKSONHAMMOND; Fiscal Year: 2012
  9. FOUR TROPICAL DISEASES IN BRAZIL
    John David; Fiscal Year: 1993
  10. PROPERTIES OF CHEMICALLY MODIFIED PHOSPHOLIPASE A-2
    Philip Rosenberg; Fiscal Year: 1993

Detail Information

Publications258 found, 100 shown here

  1. ncbi Skeletal muscle degeneration induced by venom phospholipases A2: insights into the mechanisms of local and systemic myotoxicity
    Jose Maria Gutierrez
    Instituto Clodomiro Picado, Facultad de Microbiologia, Universidad de Costa Rica, San Jose, Costa Rica
    Toxicon 42:915-31. 2003
    ..In contrast, PLA2s that bind muscle cells in a more selective way are not sequestered by non-specific interactions with other cells and, consequently, are systemically distributed and reach muscle cells in other locations...
  2. ncbi Early evolution of the venom system in lizards and snakes
    Bryan G Fry
    Australian Venom Research Unit, Level 8, School of Medicine, University of Melbourne, Parkville, Victoria 3010, Australia
    Nature 439:584-8. 2006
    ..These results provide new insights into the evolution of the venom system in squamate reptiles and open new avenues for biomedical research and drug design using hitherto unexplored venom proteins...
  3. pmc From genome to "venome": molecular origin and evolution of the snake venom proteome inferred from phylogenetic analysis of toxin sequences and related body proteins
    Bryan G Fry
    Australian Venom Research Unit, Level 8, School of Medicine, University of Melbourne, Parkville, Victoria 3010 Australia
    Genome Res 15:403-20. 2005
    ..However, this study revealed that the toxin types, where the ancestral protein was extensively cysteine cross-linked, were the ones that flourished into functionally diverse, novel toxin multigene families...
  4. ncbi Chemical modifications of phospholipases A2 from snake venoms: effects on catalytic and pharmacological properties
    Andreimar M Soares
    Departamento de Biotecnologia, Universidade de Ribeirão Preto UNAERP, Ribeirão Presto, SP, Brazil
    Toxicon 42:855-68. 2003
    Phospholipases A2 (PLA2s) constitute major components of snake venoms and have been extensively investigated not only because they are very abundant in these venoms but mainly because they display a wide range of biological effects, ..
  5. ncbi Novel transcripts in the maxillary venom glands of advanced snakes
    Bryan G Fry
    Venom Evolution Laboratory, School of Biological Sciences, University of Queensland, St Lucia, Queensland 4072, Australia
    Toxicon 59:696-708. 2012
    ..were also recovered for the only recently characterised veficolin toxin class also shared between lizard and snake venoms. The additional complexity of snake venoms has important implications not only for understanding their ..
  6. ncbi Purification and partial characterization of two phospholipases A2 from Bothrops leucurus (white-tailed-jararaca) snake venom
    D A Higuchi
    University of Mogi das Cruzes, Av Dr Candido Xavier de Almeida Souza 200, Centro Cívico, CEP 08780 911 Mogi das Cruzes, Sao Paulo, Brazil
    Biochimie 89:319-28. 2007
    ..blD-PLA(2) did not have any effect upon platelet aggregation induced by arachidonic acid, ADP or collagen, but strongly inhibits coagulation and is able to stimulate Ehrlich tumor growth but not angiogenesis...
  7. ncbi Molding the business end of neurotoxins by diversifying evolution
    Adi Kozminsky-Atias
    Department of Life Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    FASEB J 26:576-86. 2012
    ..Furthermore, we propose that the binding domains of unstudied toxins could be readily predicted using evolutionary considerations...
  8. ncbi Excitement ahead: structure, function and mechanism of snake venom phospholipase A2 enzymes
    R Manjunatha Kini
    Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore 117543
    Toxicon 42:827-40. 2003
    ..Thus research in this field will provide a lot of exciting opportunities...
  9. ncbi Assembling an arsenal: origin and evolution of the snake venom proteome inferred from phylogenetic analysis of toxin sequences
    B G Fry
    Australian Venom Research Unit, Department of Pharmacology, University of Melbourne, Parkville, Australia
    Mol Biol Evol 21:870-83. 2004
    ..Moreover, they provide a first insight into the composition of the earliest ophidian venoms and point the way toward a research program that could elucidate the functional context of the evolution of the snake venom proteome...
  10. ncbi Snake bite
    David A Warrell
    Nuffield Department of Clinical Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Lancet 375:77-88. 2010
    ..Its public health importance has been largely ignored by medical science. Snake venoms are rich in protein and peptide toxins that have specificity for a wide range of tissue receptors, making them ..
  11. pmc Profiling the venom gland transcriptomes of Costa Rican snakes by 454 pyrosequencing
    Jordi Durbán
    Consejo Superior de Investigaciones Cientificas, Jaime Roig, Valencia, Spain
    BMC Genomics 12:259. 2011
    ..In the absence of genome sequence, transcriptomes represent also valuable searchable databases for proteomic projects...
  12. ncbi Domain loss facilitates accelerated evolution and neofunctionalization of duplicate snake venom metalloproteinase toxin genes
    Nicholas R Casewell
    Alistair Reid Venom Research Unit, Liverpool School of Tropical Medicine, Liverpool, United Kingdom
    Mol Biol Evol 28:2637-49. 2011
    ....
  13. ncbi Inflammatory effects of snake venom myotoxic phospholipases A2
    C F P Teixeira
    Laboratories of Pharmacology, Instituto Butantan, 05503 900 Sao Paulo, SP, Brazil
    Toxicon 42:947-62. 2003
    ..This work reviews the proinflammatory and nociceptive effects evoked by myotoxic PLA2s and their mechanisms of action...
  14. ncbi Evolution of an arsenal: structural and functional diversification of the venom system in the advanced snakes (Caenophidia)
    Bryan G Fry
    Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3010, Australia
    Mol Cell Proteomics 7:215-46. 2008
    ....
  15. ncbi Randomized phase II study of cilengitide, an integrin-targeting arginine-glycine-aspartic acid peptide, in recurrent glioblastoma multiforme
    David A Reardon
    Duke University Medical Center, Durham, NC 27710, USA
    J Clin Oncol 26:5610-7. 2008
    ..The current multicenter phase II study was conducted to evaluate the activity and safety of cilengitide in GBM patients at first recurrence...
  16. ncbi Snake venom components and their applications in biomedicine
    D C I Koh
    Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 8 Medical Drive, Singapore, 117597, Singapore
    Cell Mol Life Sci 63:3030-41. 2006
    ..This review will focus on certain snake venom components and their applications in health and disease...
  17. ncbi Structural and pharmacological features of phospholipases A2 from snake venoms
    Rafael Cisne de Paula
    Departamento de Biologia Celular e Molecular, Instituto de Biologia, Universidade Federal Fluminense, Niteroi, RJ, Brasil
    Protein Pept Lett 16:899-907. 2009
    Phospholipases A(2) enzymes are found in many biological sources, including snake venoms. Here we reviewed aspects of PLA(2)s including biological and structural features, interaction with binding receptors, inhibitors used on structure-..
  18. ncbi Importance of snake venom metalloproteinases in cell biology: effects on platelets, inflammatory and endothelial cells
    A M Moura-da-Silva
    Laboratorio de Imunopatologia, Instituto Butantan, Av Vital Brasil, 1500, 05503 900, Sao Paulo, SP, Brazil
    Curr Pharm Des 13:2893-905. 2007
    Snake venom metalloproteinases (SVMPs) are widely distributed in snake venoms and play important roles in hemostatic disorders and local tissue damage that follows snakebite...
  19. ncbi Cellular pathology induced by snake venom phospholipase A2 myotoxins and neurotoxins: common aspects of their mechanisms of action
    C Montecucco
    Instituto Clodomiro Picado, Facultad de Microbiologia, Universidad de Costa Rica, San Jose 2060, Costa Rica
    Cell Mol Life Sci 65:2897-912. 2008
    ..The different systemic pathophysiological consequences caused by these toxins are not due to different mechanisms of cell toxicity, but to the intrinsic anatomical and physiological properties of the targeted tissues and cells...
  20. ncbi Structural and functional comparison of proteolytic enzymes from plant latex and snake venoms
    Júnia de O Costa
    Institute of Genetics and Biochemistry, Federal University of Uberlandia, MG, Brazil
    Biochimie 92:1760-5. 2010
    ..classification, functions, location, inhibition, activation, and therapeutic applications of proteases from snake venoms and vegetables...
  21. ncbi Isolation of a neurotoxin (alpha-colubritoxin) from a nonvenomous colubrid: evidence for early origin of venom in snakes
    Bryan G Fry
    Department of Biological Sciences, Faculty of Science, National University of Singapore, 119260 Singapore
    J Mol Evol 57:446-52. 2003
    ..These results support the role of venom as a key evolutionary innovation in the early diversification of advanced snakes and provide evidence that forces a fundamental rethink of the very concept of nonvenomous snake...
  22. ncbi Haemostatically active proteins in snake venoms
    Tamara Sajevic
    Department of Molecular and Biomedical Sciences, Jozef Stefan Institute, Jamova 39, SI 1000 Ljubljana, Slovenia
    Toxicon 57:627-45. 2011
    ..haemostatically active proteinases, phospholipases A₂, L-amino acid oxidases and 5'-nucleotidases from snake venoms. We also survey the non-enzymatic effectors of haemostasis from snake venoms--disintegrins, C-type lectins and ..
  23. ncbi Plant natural products active against snake bite--the molecular approach
    W B Mors
    Nucleo de Pesquisas de Produtos Naturais, Centro de Ciencias de Saude, Universidade Federal do Rio de Janeiro, Brazil
    Phytochemistry 55:627-42. 2000
    The article surveys the substances identified in plants reputed to neutralize the effects of snake venoms. Protective activity of many of them against the lethal action of the venom of the jararaca (Bothrops jararaca) snake was confirmed ..
  24. ncbi Snake venom metalloproteinases: their role in the pathogenesis of local tissue damage
    J M Gutierrez
    Instituto Clodomiro Picado, Facultad de Microbiologia, Universidad de Costa Rica, San Jose, Costa Rica
    Biochimie 82:841-50. 2000
    The biochemical characteristics of hemorrhagic metalloproteinases isolated from snake venoms are reviewed, together with their role in the pathogenesis of the local tissue damage characteristic of crotaline and viperine snake ..
  25. ncbi Snake venoms and hemostasis
    Q Lu
    Theodor Kocher Institute, University of Berne, Berne, Switzerland
    J Thromb Haemost 3:1791-9. 2005
    b>Snake venoms are complex mixtures of biologically active proteins and peptides. Many of them affect hemostasis by activating or inhibiting coagulant factors or platelets, or by disrupting endothelium...
  26. pmc Confronting the neglected problem of snake bite envenoming: the need for a global partnership
    Jose Maria Gutierrez
    Instituto Clodomiro Picado, Facultad de Microbiologia, Universidad de Costa Rica, San Jose, Costa Rica
    PLoS Med 3:e150. 2006
  27. ncbi Accelerated evolution and molecular surface of venom phospholipase A2 enzymes
    R M Kini
    Bioscience Centre, Faculty of Science, National University of Singapore, 10, Kent Ridge Crescent, Singapore 119260
    J Mol Evol 48:125-32. 1999
    ..Thus natural substitutions in PLA2 enzymes, in contrast to popular belief, are not random substitutions but appear to be directed toward modifying the molecular surface...
  28. ncbi Snake venom serine proteinases: sequence homology vs. substrate specificity, a paradox to be solved
    Solange M T Serrano
    Laboratório Especial de Toxinologia Aplicada CAT CEPID, Instituto Butantan, Av Vital Brasil 1500, 05503 900 Sao Paulo SP, Brazil
    Toxicon 45:1115-32. 2005
    ..In this review we describe their biochemical/biophysical characteristics, biological activities as well as aspects of their evolution and structure-activity relationship...
  29. ncbi Animal experimentation in snake venom research and in vitro alternatives
    Paula G Sells
    Alistair Reid Venom Research Unit, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK
    Toxicon 42:115-33. 2003
    ..In the meantime, the principles of Reduce, Refine and Replace relating to animals in research are increasingly endorsed by those working in the field and the many agencies regulating ethical and research policy...
  30. ncbi Snake venom phospholipases A(2): a novel tool against bacterial diseases
    R P Samy
    Infectious Diseases Programme, Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597
    Curr Med Chem 19:6150-62. 2012
    ..In fact, the C-terminal cationic/hydrophobic segment (residues 115-129) of svPLA(2)s is bactericidal. Thus identification of the bactericidal sites in svPLA(2)s has potential for developing novel antimicrobials...
  31. ncbi Snake venomics. Strategy and applications
    Juan J Calvete
    Instituto de Biomedicina de Valencia, CSIC, Jaume Roig 11, 46010 Valencia, Spain
    J Mass Spectrom 42:1405-14. 2007
    ..The combined strategy allows us to assign unambiguously all the isolated venom toxins representing over 0.05% of the total venom proteins to known protein families. Protocols and applications of snake venomics are reviewed and discussed...
  32. pmc Pseudechetoxin: a peptide blocker of cyclic nucleotide-gated ion channels
    R L Brown
    Neurological Sciences Institute, Oregon Health Sciences University, 1120 NW 20th Avenue, Portland, OR 97209, USA
    Proc Natl Acad Sci U S A 96:754-9. 1999
    ..PsTx promises to be a valuable pharmacological tool for studies on the structure and physiology of CNG channels...
  33. ncbi Snake venomics and antivenomics: Proteomic tools in the design and control of antivenoms for the treatment of snakebite envenoming
    Jose Maria Gutierrez
    Instituto Clodomiro Picado, Facultad de Microbiologia, Universidad de Costa Rica, San Jose, Costa Rica
    J Proteomics 72:165-82. 2009
    ..This work discusses several aspects of antivenom manufacture and control in which the proteomic analysis of snake venoms, for which the term 'snake venomics' has been coined, might play a relevant supporting role...
  34. ncbi Structural considerations of the snake venom metalloproteinases, key members of the M12 reprolysin family of metalloproteinases
    Jay W Fox
    Department of Microbiology, Health Sciences Center, University of Virginia, Charlottesville, VA 22908 0734, USA
    Toxicon 45:969-85. 2005
    ..What the reader will observe is that there are very interesting structural features displayed by the various SVMP classes and subclasses that provide insight into their functional characteristics...
  35. pmc Inventing an arsenal: adaptive evolution and neofunctionalization of snake venom phospholipase A2 genes
    Vincent J Lynch
    Department of Ecology and Evolutionary Biology, Yale University, New Haven, CT 06511, USA
    BMC Evol Biol 7:2. 2007
    ..Snake venom phospholipase A2 genes are members of large multigene families with many diverse functions, thus they are excellent models to study the emergence of novel functions after gene duplications...
  36. pmc Atractaspis aterrima toxins: the first insight into the molecular evolution of venom in side-stabbers
    Yves Terrat
    Montreal University, Research Institute in Plant Biology, Montreal Botanical Garden, Montreal, Quebec, Canada
    Toxins (Basel) 5:1948-64. 2013
    Although snake venoms have been the subject of intense research, primarily because of their tremendous potential as a bioresource for design and development of therapeutic compounds, some specific groups of snakes, such as the genus ..
  37. ncbi Cilengitide inhibits metastatic bone colonization in a nude rat model
    Maren Bretschi
    Department of Medical Physics in Radiology, German Cancer Research Center, 69120 Heidelberg, Germany
    Oncol Rep 26:843-51. 2011
    ..In conclusion, during early pathogenic processes of bone colonization, cilengitide treatment exerted effects on tumor cells, osteoclasts and vasculature reducing the skeletal lesion size of experimental skeletal metastases...
  38. ncbi In vitro neuromuscular activity of snake venoms
    Wayne C Hodgson
    Department of Pharmacology, Monash Venom Group, PO Box 13E, Monash University, Melbourne, Victoria 3800, Australia
    Clin Exp Pharmacol Physiol 29:807-14. 2002
    1. Snake venoms consist of a multitude of pharmacologically active components used for the capture of prey. Neurotoxins are particularly important in this regard, producing paralysis of skeletal muscles...
  39. ncbi Bites of venomous snakes
    Barry S Gold
    Division of Emergency Medicine, University of Maryland School of Medicine, Baltimore 21201 1539, USA
    N Engl J Med 347:347-56. 2002
  40. ncbi Gene tree parsimony of multilocus snake venom protein families reveals species tree conflict as a result of multiple parallel gene loss
    Nicholas R Casewell
    School of Biological Sciences, Environment Centre Wales, Bangor University, Bangor, United Kingdom
    Mol Biol Evol 28:1157-72. 2011
    ..These results highlight the potential for gene tree parsimony analyses to be undermined by rapidly evolving multilocus gene families under strong natural selection...
  41. ncbi Protein complexes in snake venom
    R Doley
    Protein Science Laboratory, Department of Biological Sciences, Faculty of Science, National University of Singapore, 10 Kent Ridge Crescent, Singapore 119260, Singapore
    Cell Mol Life Sci 66:2851-71. 2009
    ..Here, we describe the structure and function of various protein complexes of snake venoms and their role in snake venom toxicity.
  42. ncbi Integrin alpha v beta 3 antagonist Cilengitide enhances efficacy of radiotherapy in endothelial cell and non-small-cell lung cancer models
    Jeffrey M Albert
    Department of Radiation Oncology, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA
    Int J Radiat Oncol Biol Phys 65:1536-43. 2006
    ..Radiotherapy also inhibits tumor growth and affects vasculature. We explored the combination of integrin antagonist Cilengitide (EMD 121974) and ionizing radiation...
  43. ncbi Comparison of textilinin-1 with aprotinin as serine protease inhibitors and as antifibrinolytic agents
    Simone Flight
    School of Medicine, University of Queensland, Princess Alexandra Hospital, Brisbane, Australia
    Pathophysiol Haemost Thromb 34:188-93. 2005
    ..9 +/- 0.7). The same trend was found with the lysis of euglobulin fractions. From these data textilinin-1 appears to be a more specific plasmin inhibitor than aprotinin but aprotinin inhibits clot lysis to a greater extent...
  44. ncbi Phase I and pharmacokinetic study of continuous twice weekly intravenous administration of Cilengitide (EMD 121974), a novel inhibitor of the integrins alphavbeta3 and alphavbeta5 in patients with advanced solid tumours
    F A L M Eskens
    Erasmus Medical Center, Department of Medical Oncology, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Eur J Cancer 39:917-26. 2003
    ..Cilengitide can be safely administered using a continuous twice-weekly infusion regimen. As DLT was not reached, future trials should explore Cilengitide at different doses...
  45. ncbi [Understanding snake venoms: 50 years of research in Latin America]
    Jose Maria Gutierrez
    Instituto Clodomiro Picado, Facultad de Microbiologia, Universidad de Costa Rica, San Jose, Costa Rica
    Rev Biol Trop 50:377-94. 2002
    ..Toxinology has become a fruitful and stimulating research field in Latin America which has contributed to a better understanding of snake venoms as well as to an improved management of snake bitten patients.
  46. ncbi Radiation sensitization of glioblastoma by cilengitide has unanticipated schedule-dependency
    Tom Mikkelsen
    Department of Neurosurgery, Hermelin Brain Tumor Center, Henry Ford Hospital, Detroit, MI 48202, USA
    Int J Cancer 124:2719-27. 2009
    ..Our results demonstrate that blockade of alphav integrins mediates an unanticipated rapid potentiation of radiation, and suggests possible clinical translation for glioma therapy...
  47. ncbi Venoms, venomics, antivenomics
    Juan J Calvete
    Instituto de Biomedicina de Valencia, C S I C, Jaume Roig 11, 46010 Valencia, Spain
    FEBS Lett 583:1736-43. 2009
    ..Here we review our proteomic protocols for uncoiling the composition, immunological profile, and evolution of snake venoms. Our long-term goal is to gain a deep insight of all viperid venom proteomes...
  48. ncbi Cilengitide targeting of alpha(v)beta(3) integrin receptor synergizes with radioimmunotherapy to increase efficacy and apoptosis in breast cancer xenografts
    Patricia A Burke
    University of California at Davis, Sacramento Medical Center, Radiodiagnosis and Therapy Internal Medicine, Sacramento, California 95816, USA
    Cancer Res 62:4263-72. 2002
    ..The enhanced therapeutic synergy is of particular note, having been achieved without additional toxicity...
  49. ncbi Stability, distribution and use of antivenoms for snakebite envenomation in Latin America: report of a workshop
    Jose Maria Gutierrez
    Instituto Clodomiro Picado, Facultad de Microbiologia, Universidad de Costa Rica, 1000 San José, Costa Rica
    Toxicon 53:625-30. 2009
    ..It was concluded that, in addition to the fostering of antivenom production and quality control, renewed efforts should be implemented at improving the stability, distribution and correct use of antivenoms in the region...
  50. ncbi Envenoming bites by kraits: the biological basis of treatment-resistant neuromuscular paralysis
    S Prasarnpun
    School of Neurology, Neurobiology and Psychiatry, Faculty of Medical Sciences, University of Newcastle upon Tyne, UK
    Brain 128:2987-96. 2005
    ....
  51. ncbi Some aspects of the venom proteome of the Colubridae snake Philodryas olfersii revealed from a Duvernoy's (venom) gland transcriptome
    Ana T C Ching
    Centro de Biotecnologia, Instituto Butantan, Av Vital Brazil, 1500, Sao Paulo, SP 05503 900, Brazil
    FEBS Lett 580:4417-22. 2006
    ..We suggest that these precursors constitute a monophyletic group derived from the vertebrate CNPs...
  52. ncbi Effect of crotapotin and heparin on the rat paw oedema induced by different secretory phospholipases A2
    E C Landucci
    Department of Pharmacology, Faculty of Medical Sciences, UNICAMP, Campinas, SP, Brazil
    Toxicon 38:199-208. 2000
    ..Since heparin reduced paw oedema induced by PLA2 from Naja mocambique mocambique venom it is likely that this sPLA2 is similar to the novel heparin-sensitive PLA2 found in mast cells...
  53. ncbi Snake venom fibrin(ogen)olytic enzymes
    S Swenson
    Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Centre, University of Southern California, Keck School of Medicine, Los Angeles, CA 90033, USA
    Toxicon 45:1021-39. 2005
    b>Snake venoms contain a number of serine and metalloproteinases and included among these are the fibrin(ogen)olytic proteinases. Some years ago it was postulated that the fibrin(ogen)olytic enzymes may be clinically useful...
  54. ncbi Trends in snakebite envenomation therapy: scientific, technological and public health considerations
    Jose Maria Gutierrez
    Instituto Clodomiro Picado, Facultad de Microbiologia, Universidad de Costa Rica, San Jose, Costa Rica
    Curr Pharm Des 13:2935-50. 2007
    ..b) The growing knowledge on the biochemistry and toxicology of snake venoms should pave the way for the identification of natural and synthetic inhibitors of venom toxins, particularly of ..
  55. ncbi Antibacterial activity of snake, scorpion and bee venoms: a comparison with purified venom phospholipase A2 enzymes
    R Perumal Samy
    Venom and Toxin Research Programme, Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    J Appl Microbiol 102:650-9. 2007
    ..Venoms of snakes, scorpions, bees and purified venom phospholipase A(2) (PLA(2)) enzymes were examined to evaluate the antibacterial activity of purified venom enzymes as compared with that of the crude venoms...
  56. ncbi A new Pan African polyspecific antivenom developed in response to the antivenom crisis in Africa
    G D Laing
    Alistair Reid Venom Research Unit, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK
    Toxicon 42:35-41. 2003
    ..This new antivenom, and a similar product being manufactured in Costa Rica, are now candidates for clinical testing at an appropriate site in Africa...
  57. pmc Anticoagulant proteins from snake venoms: structure, function and mechanism
    R Manjunatha Kini
    Protein Science Laboratory, Department of Biological Sciences, Faculty of Science, National University of Singapore, 14 Science Drive 4, Singapore
    Biochem J 397:377-87. 2006
    ..This review describes the details of the structure, mechanism and structure-function relationships of anticoagulant proteins from snake venoms.
  58. ncbi Medicinal plants with inhibitory properties against snake venoms
    Andreimar M Soares
    Departamento de Analises Clinicas, Toxicologicas e Bromatologicas, Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, FCFRP, Universidade de Sao Paulo, USP, Ribeirao Preto SP, Brazil
    Curr Med Chem 12:2625-41. 2005
    ..This article presents a review of plants showing neutralizing properties against snake venoms which were assayed in research laboratories, correlating them with ethnopharmacological studies, as (i) the ..
  59. ncbi Alpha neurotoxins
    Carmel M Barber
    Monash Venom Group, Department of Pharmacology, Monash University, Clayton, Victoria 3800, Australia
    Toxicon 66:47-58. 2013
    Neurotoxins have been isolated from hydrophid, elapid and, more recently, colubrid snake venoms. Also referred to as postsynaptic neurotoxins or 'curare mimetic' neurotoxins, they play an important role in the capture and/or killing of ..
  60. pmc Neuromuscular effects of candoxin, a novel toxin from the venom of the Malayan krait (Bungarus candidus)
    S Nirthanan
    Venom and Toxin Research Programme, Department of Pharmacology, Faculty of Medicine, National University of Singapore, Singapore
    Br J Pharmacol 139:832-44. 2003
    ..In contrast, curaremimetic alpha-neurotoxins have been reported to antagonize both binding sites with equal affinity...
  61. ncbi Analysis of Colubroidea snake venoms by liquid chromatography with mass spectrometry: evolutionary and toxinological implications
    Bryan G Fry
    Department of Pharmacology, University of Melbourne, Parkville, VIC 3010, Australia
    Rapid Commun Mass Spectrom 17:2047-62. 2003
    ..The data will also be useful in biodiscovery...
  62. ncbi Snakebite-induced acute kidney injury in Latin America
    Fábia M Oliveira Pinho
    Department of Medicine, Catholic University of Goias, Goiania, Brazil
    Semin Nephrol 28:354-62. 2008
    ..In this article the main characteristics of Bothrops and Crotalus snakes and their venoms, the clinical picture, and the pattern of accidents, risk factors, and mechanisms of renal injury are reviewed...
  63. pmc Peptidomics of three Bothrops snake venoms: insights into the molecular diversification of proteomes and peptidomes
    Alexandre K Tashima
    Laboratório Especial de Toxinologia Aplicada, CAT CEPID, Instituto Butantan, Sao Paulo, Brazil
    Mol Cell Proteomics 11:1245-62. 2012
    ..The use of proteinase inhibitors clearly showed different outcomes in the peptidome characterization and suggested that degradomic-peptidomic analysis of snake venoms is highly sensitive to the conditions of sampling procedures.
  64. ncbi A family of textilinin genes, two of which encode proteins with antihaemorrhagic properties
    Igor Filippovich
    The Queensland Cancer Fund Research Unit, The Queensland Institute of Medical Research, Royal Brisbane Hospital, Herston, Australia
    Br J Haematol 119:376-84. 2002
    ....
  65. ncbi Inhibitors of snake venoms and development of new therapeutics
    Elda E Sanchez
    Natural Toxins Research Center, College of Arts and Sciences, Texas A and M University Kingsville, Kingsville, Texas, USA
    Immunopharmacol Immunotoxicol 30:647-78. 2008
    Natural inhibitors of snake venoms play a significant role in the ability to neutralize the degradation effects induced by venom toxins...
  66. ncbi Snake venom glutaminyl cyclase
    Joanna Pawlak
    Department of Biological Sciences, Faculty of Science, National University of Singapore, Science Drive 4, Singapore 117543, Singapore
    Toxicon 48:278-86. 2006
    ..We propose that QC expressed in snake venom gland tissue plays a role in the N-terminal pyroglutamate formation of several snake venom toxins, indirectly contributing to venom potency...
  67. ncbi Pro and antiinflammatory properties of toxins from animal venoms
    Sandra H P Farsky
    Rheumatology Division, Department of Internal Medicine, School of Medicine, University of Sao Paulo, Av Dr Arnaldo 455, Sao Paulo, SP, CEP 01246 903, Brazil
    Curr Drug Targets Inflamm Allergy 4:401-11. 2005
    ....
  68. ncbi What have snakes taught us about integrins?
    T F Huang
    Pharmacological Institute, College of Medicine, National Taiwan University, Taipei
    Cell Mol Life Sci 54:527-40. 1998
    b>Snake venoms contain unique components that affect cell-matrix interactions...
  69. ncbi Antivenom use, premedication and early adverse reactions in the management of snake bites in rural Papua New Guinea
    David J Williams
    School of Public Health and Tropical Medicine, James Cook University, Townsville, QLD, Australia
    Toxicon 49:780-92. 2007
    ..To examine antivenom use, premedication, early adverse reactions and patient outcomes after snake bite in rural Papua New Guinea...
  70. ncbi An overview on nucleases (DNase, RNase, and phosphodiesterase) in snake venoms
    B L Dhananjaya
    Department of Studies in Biochemistry, University of Mysore, Manasagangothri, Mysore, 570006, India
    Biochemistry (Mosc) 75:1-6. 2010
    ..We hope that this review will stimulate renewed interest among toxicologists to biologically characterize these enzymes and elucidate their role in envenomation...
  71. ncbi Evolution of snake venom disintegrins by positive Darwinian selection
    Paula Juárez
    Instituto de Biomedicina de Valencia, Consejo Superior de Investigaciones Biológicas, Valencia, Spain
    Mol Biol Evol 25:2391-407. 2008
    ..Perhaps, this represents a consequence of the neofunctionalization potential of the disintegrin domain, a feature that may underlie its recruitment into the venom proteome followed by its successful transformation into a toxin...
  72. ncbi Snake venom disintegrins: evolution of structure and function
    Juan J Calvete
    Instituto de Biomedicina de Valencia, C S I C, Jaume Roig 11, 46010 Valencia, Spain
    Toxicon 45:1063-74. 2005
    ..The role of the composition, conformation, and dynamics of the integrin inhibitory loop acting in concert with the C-terminal tail in determining the selective inhibition of integrin receptors is discussed...
  73. ncbi Integrins: molecular targets in cancer therapy
    Gordon C Tucker
    Institut de Recherches Servier, Cancer Drug Discovery, 125 Chemin de Ronde, 78290 Croissy sur Seine, France
    Curr Oncol Rep 8:96-103. 2006
    ..Possible reasons for this are discussed in this review. The parallel development of integrin antagonists as imaging tools for patient selection may accelerate the discovery of new avenues for their use...
  74. pmc Phase I and correlative biology study of cilengitide in patients with recurrent malignant glioma
    L Burt Nabors
    New Approaches to Brain Tumor Therapy CNS Consortium, Baltimore, MD 21231, USA
    J Clin Oncol 25:1651-7. 2007
    ..This multi-institutional phase I trial was designed to determine the maximum-tolerated dose (MTD) of cilengitide (EMD 121974) and to evaluate the use of perfusion magnetic resonance imaging (MRI) in patients with recurrent malignant glioma...
  75. ncbi Lebectin and lebecetin, two C-type lectins from snake venom, inhibit alpha5beta1 and alphaV-containing integrins
    Sameh Sarray
    Institut Pasteur de Tunis, Tunis, Tunisia
    Matrix Biol 26:306-13. 2007
    ..Lebectin and lebecetin are thus the first examples of venom C-type lectins inhibiting an integrin other than the collagen receptor alpha2beta1...
  76. ncbi alpha(9)beta(1) integrin engagement inhibits neutrophil spontaneous apoptosis: involvement of Bcl-2 family members
    Roberta F Saldanha-Gama
    Departamento de Farmacologia, Instituto de Biologia Roberto Alcantara Gomes, Universidade do Estado do Rio de Janeiro, Avenida 28 de Setembro 87 Fundos, 5 degrees andar, Vila Isabel, Rio de Janeiro, RJ, Brasil CEP 20511 030
    Biochim Biophys Acta 1803:848-57. 2010
    ....
  77. ncbi Snakebite nephropathy
    Visith Sitprija
    Queen Saovabha Memorial Institute and King Chulalongkorn Memorial Hospital, Bangkok, Thailand
    Nephrology (Carlton) 11:442-8. 2006
    ..Direct nephrotoxicity can be induced by the venom through metalloproteases and phosphilipase A2. Immunologic mechanism plays a minor role in the pathogenesis of the renal lesion...
  78. ncbi Bothrops insularis venomics: a proteomic analysis supported by transcriptomic-generated sequence data
    Richard H Valente
    Oswaldo Cruz Foundation, IOC, Laboratory of Toxinology, Rio de Janeiro, Brazil
    J Proteomics 72:241-55. 2009
    ..Altogether, our data point to the influence of transcriptional and post-translational events on the final venom composition and stress the need for a multivariate approach to snake venomics studies...
  79. ncbi Molecular cloning of disintegrin-like transcript BA-5A from a Bitis arietans venom gland cDNA library: a putative intermediate in the evolution of the long-chain disintegrin bitistatin
    Paula Juárez
    Instituto de Biomedicina de Valencia, CSIC, Jaime Roig 11, 46010 Valencia, Spain
    J Mol Evol 63:142-52. 2006
    ..Whether BA-5A plays a physiological role or represents an orphan protein which could eventually evolve a role in the adaptation of snakes to changing ecological niches and prey habits deserves further investigation...
  80. ncbi Antimicrobial proteins from snake venoms: direct bacterial damage and activation of innate immunity against Staphylococcus aureus skin infection
    R P Samy
    Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597
    Curr Med Chem 18:5104-13. 2011
    ..Antimicrobial proteins produced by snake venoms have recently attracted significant attention due to their relevance to bacterial infection and potential ..
  81. ncbi Human anti-snake venom IgG antibodies in a previously bitten snake-handler, but no protection against local envenoming
    Geoffrey K Isbister
    Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle Hospital, New South Wales, Australia
    Toxicon 55:646-9. 2010
    ..However, despite the presence of antibodies to death adder venom and free venom not being detected, the patient still developed significant local myotoxicity...
  82. ncbi Peptide fingerprinting of snake venoms by direct infusion nano-electrospray ionization mass spectrometry: potential use in venom identification and taxonomy
    Gustavo H M F Souza
    Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas UNICAMP, Campinas, SP, Brazil
    J Mass Spectrom 43:594-9. 2008
    ..Most of these studies have concentrated on components heavier than 3 kDa, but Bothrops snake venoms contain many biologically active peptides, principally C-type natriuretic peptides and bradykinin-potentiating ..
  83. ncbi Biological and structural characterization of crotoxin and new isoform of crotoxin B PLA(2) (F6a) from Crotalus durissus collilineatus snake venom
    Luis Alberto Ponce-Soto
    Departamento de Bioquimica, Instituto de Biologia IB, Universidade Estadual de Campinas UNICAMP, CP 6109, CEP 13083 970 Campinas, SP, Brazil
    Protein J 26:221-30. 2007
    ..Whole crotoxin was devoid of cytolytic activity upon myoblasts and myotubes in vitro, whereas new crotoxin B isoform PLA(2) (F6a) was clearly cytotoxic to these cells...
  84. ncbi Unmasking venom gland transcriptomes in reptile venoms
    Tianbao Chen
    Pharmaceutical Biotechnology, School of Biomedical Sciences, University of Ulster, Coleraine BT52 1SA, Ireland
    Anal Biochem 311:152-6. 2002
    ....
  85. ncbi Snake venoms and the neuromuscular junction
    Robert L Lewis
    Department of Neurology, Robert C Byrd Health Sciences Center, West Virginia University, Morgantown, West Virginia 26505, USA
    Semin Neurol 24:175-9. 2004
    ..A unique feature of timber rattlesnake venom is its ability to cause clinical myokymia. This likely results from a blockade of voltage gated K+ antibodies...
  86. ncbi Snake venom probes of platelet adhesion receptors and their ligands
    Lakshmi C Wijeyewickrema
    Department of Biochemistry and Molecular Biology, Monash University, Wellington Road, Clayton, VIC 3168, Australia
    Toxicon 45:1051-61. 2005
    ..Whether homologous adhesion/counter-receptors on platelets and other vascular cells are also potential snake venom targets is as yet largely unexplored...
  87. ncbi Snake venom alpha-neurotoxins and other 'three-finger' proteins
    V Tsetlin
    Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia
    Eur J Biochem 264:281-6. 1999
    ..The main emphasis is placed on recent data characterizing the alpha-neurotoxin interactions with nicotinic acetylcholine receptors...
  88. ncbi BJ46a, a snake venom metalloproteinase inhibitor. Isolation, characterization, cloning and insights into its mechanism of action
    R H Valente
    , , Rio de Janeiro, Brazil
    Eur J Biochem 268:3042-52. 2001
    ..Furthermore, the data shows that the stoichiometry involved in this interaction is of one inhibitor monomer to two enzyme molecules, suggesting an interesting mechanism of metalloproteinase inhibition...
  89. ncbi Inhibitory effect of tea polyphenols on local tissue damage induced by snake venoms
    P Pithayanukul
    Department of Pharmacy, Faculty of Pharmacy, Mahidol University, Bangkok 10400, Thailand
    Phytother Res 24:S56-62. 2010
    ..It is suggested that the inhibitory potential of the CS extract against local tissue damage induced by snake venoms may be attributed to complexation and chelation between the venom proteins and the phenolic contents of the ..
  90. ncbi Anti-necrosis potential of polyphenols against snake venoms
    Jiraporn Leanpolchareanchai
    Department of Pharmacy, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand
    Immunopharmacol Immunotoxicol 31:556-62. 2009
    ..The inhibitory activity of plant polyphenols against local tissue necrosis induced by snake venoms may be caused by inhibition of inflammatory reactions, hemorrhage, and necrosis...
  91. ncbi Preliminary in vitro studies on the Marsypianthes chamaedrys (boia-caá) extracts at fibrinoclotting induced by snake venoms
    K N C Castro
    Departamento de Bioquimica Medica, ICB CCS, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941 590, Brazil
    Toxicon 41:929-32. 2003
    ..used against snakebites, in the present study was shown to inhibit fibrinoclotting induced by several Brazilian snake venoms or thrombin. These data indicate that this extract affected thrombin-like enzymes...
  92. ncbi Current use of Australian snake antivenoms and frequency of immediate-type hypersensitivity reactions and anaphylaxis
    Geoffrey K Isbister
    Menzies School of Health Research, Charles Darwin University, Darwin, NT
    Med J Aust 188:473-6. 2008
    ..To investigate current use of Australian snake antivenoms and the frequency and severity of immediate-type hypersensitivity reactions...
  93. ncbi Antidotes against venomous animals: state of the art and prospectives
    G P Espino-Solis
    Departamento de Medicina Molecular y Bioprocesos, Instituto de Biotecnologia, Universidad Nacional Autonoma de Mexico, Cuernavaca, Morelos, 62210, Mexico
    J Proteomics 72:183-99. 2009
    ....
  94. ncbi Endogenous thrombin potential as a novel method for the characterization of procoagulant snake venoms and the efficacy of antivenom
    Geoffrey K Isbister
    Faculty of Health, University of Newcastle, Newcastle, New South Wales, Australia
    Toxicon 56:75-85. 2010
    ..consumption coagulopathy occurs in snake envenoming worldwide but the interaction between procoagulant snake venoms and human coagulation remains poorly understood...
  95. ncbi Anticoagulant and antifibrinogenolytic properties of the aqueous extract from Bauhinia forficata against snake venoms
    Clayton Z Oliveira
    Unidade de Biotecnologia, Universidade de Ribeirao Preto, UNAERP, 14096 900 Ribeirão Preto, SP, Brazil
    J Ethnopharmacol 98:213-6. 2005
    ..In addition, it did not inhibited the phospholipase A2 activity of Bothrops snake venoms. Interaction studies between Bauhinia forficata extract and snake venoms, when analyzed by SDS-PAGE, did not ..
  96. ncbi Natural protease inhibitors to hemorrhagins in snake venoms and their potential use in medicine
    J C Perez
    Department of Biology, Texas A and M University Kingsville, 78363, USA
    Toxicon 37:703-28. 1999
    b>Snake venoms are complex mixtures of many toxins and enzymes which effectively immobilize prey without a struggle and assist in digestion. Certain animals have a remarkable resistance to envenomation of snakes...
  97. ncbi Estimates of disease burden due to land-snake bite in Sri Lankan hospitals
    A Kasturiratne
    Department of Community and Family Medicine, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka
    Southeast Asian J Trop Med Public Health 36:733-40. 2005
    ..Health care planning using data based on environmental information, rather than merely on political boundaries, could lead to targeted distribution of AV and intensive care requirements to manage snake bites...
  98. ncbi Epidemiological profile of snake-bite cases from Andhra Pradesh using immunoanalytical approach
    Ganneru Brunda
    Department of Biochemistry, University College of Science, Osmania University, Hyderabad, India
    Indian J Med Res 125:661-8. 2007
    ..This study was undertaken to find out the epidemiological profile of snake-bite incidences in the State of Andhra Pradesh, based on the data collected from State Forensic Science Laboratory, Hyderabad...
  99. ncbi Snake antivenoms
    David G Lalloo
    Liverpool School of Tropical Medicine, Liverpool, UK
    J Toxicol Clin Toxicol 41:277-90; 317-27. 2003
  100. pmc A randomized multi-center phase II trial of the angiogenesis inhibitor Cilengitide (EMD 121974) and gemcitabine compared with gemcitabine alone in advanced unresectable pancreatic cancer
    Helmut Friess
    Department of General Surgery, University of Heidelberg, Heidelberg, Germany
    BMC Cancer 6:285. 2006
    ..In this study, the treatment effects of the angiogenesis inhibitor Cilengitide and gemcitabine were compared with gemcitabine alone in patients with advanced unresectable pancreatic cancer...
  101. ncbi Integrin inhibitors reaching the clinic
    Roger Stupp
    J Clin Oncol 25:1637-8. 2007

Research Grants62

  1. Remote-control mouse-implantable micropumps for establishment of regenerative cap
    JUAN GABRIEL contact SANTIAGO; Fiscal Year: 2010
    ..Our mouse- implantable remote-control micropump technology overcomes this limitation;enabling more rapid, efficient, and economical discovery and delivery of regenerative therapies. ..
  2. 2010 Angiotensin Gordon Research Conference
    Kathy K Griendling; Fiscal Year: 2010
    ..Research into the actions of angiotensin continues to provide new avenues for treating patients with cardiovascular disease, thereby prolonging life and its quality. ..
  3. Center for Computational Mass-Spectrometry
    Pavel A Pevzner; Fiscal Year: 2011
    ..addressing the need to constantly reformulate the influenza vaccine to make it efficient, and (v) sequencing of snake venoms that proved instrumental in design of blood clotting drugs...
  4. Viper Resource Center (VRC) at Texas A&M University-Kingsville
    JOHN CARLOS PEREZ; Fiscal Year: 2013
    ..It is our hypothesis that snake venoms are abundant and stable sources of many molecules and once purified, characterized, and cloned, could have many ..
  5. Center for Computational Mass-Spectrometry
    Pavel A Pevzner; Fiscal Year: 2013
    ..addressing the need to constantly reformulate the influenza vaccine to make it efficient, and (v) sequencing of snake venoms that proved instrumental in design of blood clotting drugs...
  6. Studies on anticoagulant properties of thrombin
    Enrico Di Cera; Fiscal Year: 2013
    ....
  7. Prokineticin 2 and Neuroinflammatory Mechanisms
    Arthi Kanthasamy; Fiscal Year: 2013
    ....
  8. Center for Allaying Health Disparities Through Research and Education (CADRE)
    CYNTHIA JACKSONHAMMOND; Fiscal Year: 2012
    ..abstract_text> ..
  9. FOUR TROPICAL DISEASES IN BRAZIL
    John David; Fiscal Year: 1993
    ..Convit); the production of monoclonal antibodies against snake venoms for immunotherapy of snakebites will be initiated...
  10. PROPERTIES OF CHEMICALLY MODIFIED PHOSPHOLIPASE A-2
    Philip Rosenberg; Fiscal Year: 1993
    ..Clinical disorders could be associated with abnormal enzymatic activity or toxic effects unrelated to enzymatic activity...
  11. Development of Tethered Toxins for Neuroscience Research
    Nathaniel Heintz; Fiscal Year: 2006
    ..These studies will allow unprecedented precision in the genetic dissection of functions required for CNS development, function and dysfunction in vivo. ..
  12. MOLECULAR GENETICS OF HUMAN PLATELET GLYCOPROTEINS
    Jose Lopez; Fiscal Year: 2000
    ..This knowledge should prove useful for the design of anti-thrombotic agents that work by blocking primary platelet adhesion. ..
  13. VENOM PROTEASES: ACTION ON PLASMA PROTEASE
    LAWRENCE KRESS; Fiscal Year: 1991
    ....
  14. STRUCTURE FUNCTION ANALYSIS OF ALPHA NEUROTOXINS
    Edward Hawrot; Fiscal Year: 2002
    ..This information will be useful in providing valuable models for drug design efforts and in developing new pharmacological tools for the study of neuronal nAChRs. ..
  15. ULTRASENSITIVE IMMUNOASSAYS FOR CLOTTING FACTORS
    George Doellgast; Fiscal Year: 1991
    ..This project will extend the number of applications for this basic technology in the area of thrombosis research, resulting in a single technology which is universally applicable to measurement of relevant coagulation parameters...
  16. PURIFICATION OF VENOM FOR PRODUCTION OF IMMUNOTOXINS
    John Perez; Fiscal Year: 1990
    ..b>Snake venoms have many toxins and enzymes which destroy tissue rapidly...
  17. Production of plant-based recombinant human thrombin
    BRIAN HOOKER; Fiscal Year: 2002
    ..The current world market for such adhesives is over $400 million. ..
  18. KINETICS OF CHLORPROMAZINE-DOPAMINE RECEPTOR REACTIONS
    DAVID TOPPEN; Fiscal Year: 1980
    ..Kinetics studies of chlorpromazine metabolites will also be undertaken...
  19. INTERACTION OF CELLS WITH POLYMERIZING FIBRIN
    Stefan Niewiarowski; Fiscal Year: 1992
    ..We propose to test the hypothesis that polymerizing fibrin monomers bind to platelet surface receptors other than those associated with the GPIlb/IIIa complex...
  20. STRUCTURE AND FUNCTION OF THE CARDIAC CALCIUM CHANNEL
    JOSEPH MOORMAN; Fiscal Year: 1990
    ..Studies proposed in this application will undertake identification of active subunits of atrotoxin and other snake venoms as a means for subsequent isolation and purification of the calcium channel protein. 2)...
  21. METALLOPROTEASE DISINTEGRIN MDC9
    Carl Blobel; Fiscal Year: 2002
    ....
  22. ENDOGENOUS INHIBITORS OF ADAMS/MDC PROTEINASES
    Jay Fox; Fiscal Year: 2001
    ..Isolation and characterization of these inhibits could therefore be of future importance in developing novel pharmacological agents for the regulation of ADAMs proteins' functions in pathological states. ..
  23. SYNTHETIC APPROACHES TO PEPTIDE AND PROTEIN MIMETICS
    Michael Kahn; Fiscal Year: 1991
    ..the proposed essential residues for neurotoxic activity that are invariant in all cholinergic neurotoxic snake venoms, is detailed...
  24. PHOSPHOLIPASIC NEUROTOXINS--STRUCTURE AND FUNCTION
    PAUL SIGLER; Fiscal Year: 1992
    ....
  25. TWO STEP INHIBITION OF INVASION AND METASTASIS
    Yves DeClerck; Fiscal Year: 1992
    ..Inhibition of attachment will be explored using small disulfide-rich peptides from snake venoms, called disintegrins, that act to block the binding of extracellular matrix proteins to their integrin ..
  26. RADIOLABLED PEPTIDES FOR IMAGING THROMBI AND EMBOLI
    LINDA KNIGHT; Fiscal Year: 2003
    ..abstract_text> ..
  27. INVESTIGATION INTO THE FUNCTION OF FIG1
    Charles Chu; Fiscal Year: 2001
    ....
  28. STEREOCHEMISTRY OF ADENYLYL TRANSFER REACTIONS
    Ming Daw Tsai; Fiscal Year: 1980
    ....
  29. FUNCTIONS OF NEURONAL PENTRAXINS AND TCBP49
    MARK PERIN; Fiscal Year: 2003
    ..abstract_text> ..
  30. ADAMS IN MUSCLE DEVELOPMENT
    Eva Engvall; Fiscal Year: 2001
    ..This research will generate basic information on the ADAM family of protein, generate new model systems for research, and contribute new insights in the biology of muscle. ..
  31. Effects of KTS-disintegrins on cardiac endothelial cells
    MEGHAN BROWN; Fiscal Year: 2007
    ..These studies will clarify correlation between structure and function of these biologically active molecules and will be helpful for explanation of role of alpha 1 beta 1 integrin in cardiac angiogenesis. ..
  32. MESANGIAL RESPONSE TO INJURY
    Richard Johnson; Fiscal Year: 1999
    ..It is hoped that these studies will clarify the role of MC migration in both glomerular disease and development, and may provide new insights into the mechanisms of glomerular repair. ..
  33. NOVEL ULTRASENSITIVE COLORIMETRIC ASSAY FOR DNA
    Mark Triscott; Fiscal Year: 1993
    ..They are detection of the deltaF508 mutation of cystic fibrosis, a codon 12 mutation in the first exon of K- ras for colon cancer, and the mecA gene in methicillin resistant Staphlococcus aureus...
  34. THERAPEUTIC COAGULATION INHIBITOR
    Uma Sinha; Fiscal Year: 1991
    DESCRIPTION (Investigator's Abstract): A Phase I study is proposed to screen commercially available snake venoms for selective antithrombotics, specifically inhibition of Factor VIII/Tissue Factor and prothrombinase...
  35. Mesangial Cell Progenitors in Adults
    Feng Zheng; Fiscal Year: 2004
    ....
  36. MECHANSISM OF VENOM ALPHA-NEUROTOXIN ACTION
    Richard Hudson; Fiscal Year: 1980
    ..Synthetic chemical methods are used to examine the mechanism of action of the curare mimicking neurotoxins present in snake venom...
  37. INSTRUMENTATION FOR PROTEOMICS
    Jay Fox; Fiscal Year: 2001
    ..abstract_text> ..
  38. Quantative and Phospho Proteomics Instrumentation
    Jay Fox; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  39. Development of a combination therapy for the treatment of prostate cancer
    FRANCIS MARKLAND; Fiscal Year: 2007
    ..These studies will advance the clinical potential of this novel anticancer protein. [unreadable] [unreadable] [unreadable]..
  40. Antiidiotype mAb:an Antiangiogenic /Antimetastatic Agent
    FRANCIS MARKLAND; Fiscal Year: 2002
    ..According to the Angiogenesis Foundation, diseases that may be treatable with angiogenesis-based drugs encompass markets representing 20% of the $322 billion global pharmaceutical market. ..
  41. Liposomal Disintegrin: Novel and Effective Antitumor Agent Phase I
    FRANCIS MARKLAND; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  42. Melanoma Metastasis Inhibition by Eristostatin
    Mary Ann McLane; Fiscal Year: 2005
    ..This information will, in turn, lead to a rational design of therapeutic agents which would target these cells. ..
  43. Phase II Study of 44Gy from 131I-81C6 for CNS Tumors
    David Reardon; Fiscal Year: 2004
    ..To further define the toxicity of this approach and Specific Aim 3.To determine the impact of this therapy on quality of life. ..
  44. Targeting alfa 1beta1 integrin in cancer development
    Cezary Marcinkiewicz; Fiscal Year: 2007
    ..abstract_text> ..
  45. NABTC - M.D. Anderson Clinical Center
    Mark Gilbert; Fiscal Year: 2008
    ..The NABTC continues with the long-term goal of developing more effective treatments for patients with primary brain tumors, particularly malignant gliomas, combining longevity with the quality of survival. ..
  46. NEW APPLICATIONS IN BRAIN TUMOR THERAPY
    Tom Mikkelsen; Fiscal Year: 2008
    ..These efforts speak to the ultimate goal of our group and NABTT Consortium: improving the outcome of brain tumor patients. ..
  47. Novel Anticoagulant Mechanisms
    MARY HEEB; Fiscal Year: 2006
    ..We will find whether a ZPI polymorphism we identified affects function. ..
  48. Regulation- Medulloblastoma Growth by alpha-v integrins
    Tobey Macdonald; Fiscal Year: 2006
    ..The long-range goal of this work is to broaden our understanding of medulloblastoma growth, so that novel biologic therapies may be developed into new treatments for medulloblastoma, the most common malignant brain tumor in children. ..
  49. A MULTI-USE GLIOMA BIOREPOSITORY
    Tom Mikkelsen; Fiscal Year: 2006
    ..We seek support to expand this multi-use glioma biorepository into an ongoing resource of the best characterized glioma material with clinical correlative and genomic data available. ..
  50. MOLECULAR GLIOMA THERAPIES AND DIAGNOSTICS
    Tom Mikkelsen; Fiscal Year: 2004
    ..abstract_text> ..
  51. FORMS OF PROSTATE SPECIFIC ANTIGEN AND HK2 IN CANCER
    MARY HEEB; Fiscal Year: 2003
    ..Techniques will include protein purification, antibody and ELISA development, immunoblotting, enzyme activity assays, and peptide synthesis. ..
  52. INTEGRIN ANTAGONISTS IN GLIOMA BIOLOGY, IMAGING, THERAPY
    Tom Mikkelsen; Fiscal Year: 2003
    ..abstract_text> ..
  53. A Variant of Ileal Bile Acid Binding Protein in Colon Cancer
    Jeffrey Smith; Fiscal Year: 2006
    ..unreadable] [unreadable]..