wasp venoms

Summary

Summary: Venoms produced by the wasp (Vespid) family of stinging insects, including hornets; the venoms contain enzymes, biogenic amines, histamine releasing factors, kinins, toxic polypeptides, etc., and are similar to bee venoms.

Top Publications

  1. ncbi Wasp venom blocks central cholinergic synapses to induce transient paralysis in cockroach prey
    G Haspel
    Department of Life Sciences, Ben Gurion University of the Negev, P O Box 653, Beer Sheva, Israel 84105
    J Neurobiol 54:628-37. 2003
  2. pmc Integrative approach reveals composition of endoparasitoid wasp venoms
    Jeremy Goecks
    Department of Biology, Emory University, Atlanta, Georgia, United States of America
    PLoS ONE 8:e64125. 2013
  3. pmc The venom composition of the parasitic wasp Chelonus inanitus resolved by combined expressed sequence tags analysis and proteomic approach
    Bruno Vincent
    UMR 6035 CNRS, Institut de Recherche sur la Biologie de l Insecte, Faculte des Sciences et Techniques, Universite Francois Rabelais, Parc Grandmont, 37200 Tours, France
    BMC Genomics 11:693. 2010
  4. ncbi The N-glycans of yellow jacket venom hyaluronidases and the protein sequence of its major isoform in Vespula vulgaris
    Daniel Kolarich
    Department of Chemistry, University of Natural Resources and Applied Life Sciences BOKU, Vienna, Austria
    FEBS J 272:5182-90. 2005
  5. ncbi Elevated basal serum tryptase and hymenoptera venom allergy: relation to severity of sting reactions and to safety and efficacy of venom immunotherapy
    G Haeberli
    Department of Medicine, Spital Bern Ziegler, Bern, Switzerland
    Clin Exp Allergy 33:1216-20. 2003
  6. ncbi Negative regulation of prophenoloxidase (proPO) activation by a clip-domain serine proteinase homolog (SPH) from endoparasitoid venom
    Guangmei Zhang
    Insect Molecular Biology Laboratory, Plant and Pest Science, Waite Campus, University of Adelaide, Glen Osmond, SA 5064, Australia
    Insect Biochem Mol Biol 34:477-83. 2004
  7. ncbi Hymenoptera venom allergy: analysis of double positivity to honey bee and Vespula venom by estimation of IgE antibodies to species-specific major allergens Api m1 and Ves v5
    U R Muller
    Spital Bern Ziegler, Internal Medicine, Switzerland
    Allergy 64:543-8. 2009
  8. ncbi Structure of recombinant Ves v 2 at 2.0 Angstrom resolution: structural analysis of an allergenic hyaluronidase from wasp venom
    Lars K Skov
    Biostructural Research, Department of Medicinal Chemistry, The Danish University of Pharmaceutical Sciences, Universitetsparken 2, DK 2100, Denmark
    Acta Crystallogr D Biol Crystallogr 62:595-604. 2006
  9. pmc Expression of immune-response genes in lepidopteran host is suppressed by venom from an endoparasitoid, Pteromalus puparum
    Qi Fang
    State Key Laboratory of Rice Biology and Key Laboratory of Molecular Biology of Crop Pathogens and Insects of Ministry of Agriculture, Institute of Insect Sciences, Zhejiang University, Hangzhou 310029, China
    BMC Genomics 11:484. 2010
  10. ncbi The basophil activation test in the diagnosis of allergy: technical issues and critical factors
    G J Sturm
    Department of Dermatology, Medical University of Graz, Austria
    Allergy 64:1319-26. 2009

Research Grants

  1. A Model System For Host-Pathogen Interactions: Drosophila And Its Parasitic Wasps
    TODD ALEXANDER SCHLENKE; Fiscal Year: 2012
  2. REGULATION OF G PROTEINS BY MASTOPARAN
    TSUTOMU HIGASHIJIMA; Fiscal Year: 1992
  3. Role of Erythrocytes in Circulatory Control
    Randy Sprague; Fiscal Year: 2004
  4. Mechanisms of ATP Release from RBC's
    Randy Sprague; Fiscal Year: 2007
  5. IN VITRO APPROACH TO PROBLEMS OF CLINICAL ALLERGY
    David Golden; Fiscal Year: 2005
  6. A cell-free system for exocytosis in the beta-cell
    SUSANNE STRAUB SHARP; Fiscal Year: 2005
  7. POTASSIUM CHANNELS AND CEREBRAL HEMODYNAMICS AFTER BRAIN
    William Armstead; Fiscal Year: 2005
  8. Plasminogen activators and cerebral ischemic injury
    William M Armstead; Fiscal Year: 2010

Detail Information

Publications219 found, 100 shown here

  1. ncbi Wasp venom blocks central cholinergic synapses to induce transient paralysis in cockroach prey
    G Haspel
    Department of Life Sciences, Ben Gurion University of the Negev, P O Box 653, Beer Sheva, Israel 84105
    J Neurobiol 54:628-37. 2003
    ..We conclude that the transient paralytic effect of the thoracic sting can be mainly accounted for by the presence of a venom active component that induces a postsynaptic block of central cholinergic synaptic transmission...
  2. pmc Integrative approach reveals composition of endoparasitoid wasp venoms
    Jeremy Goecks
    Department of Biology, Emory University, Atlanta, Georgia, United States of America
    PLoS ONE 8:e64125. 2013
    ..Our joint transcriptomic-proteomic approach for endoparasitoid wasp venoms is generally applicable to identification of functional protein subsets from any non-genome sequenced organism.
  3. pmc The venom composition of the parasitic wasp Chelonus inanitus resolved by combined expressed sequence tags analysis and proteomic approach
    Bruno Vincent
    UMR 6035 CNRS, Institut de Recherche sur la Biologie de l Insecte, Faculte des Sciences et Techniques, Universite Francois Rabelais, Parc Grandmont, 37200 Tours, France
    BMC Genomics 11:693. 2010
    ..In parallel, proteins from pure venom were separated by gel electrophoresis and individually submitted to a nano-LC-MS/MS analysis allowing comparison of peptides and ESTs sequences...
  4. ncbi The N-glycans of yellow jacket venom hyaluronidases and the protein sequence of its major isoform in Vespula vulgaris
    Daniel Kolarich
    Department of Chemistry, University of Natural Resources and Applied Life Sciences BOKU, Vienna, Austria
    FEBS J 272:5182-90. 2005
    ..Close homologues of this new, putative hyaluronidase b (Ves v 2b) were also the major isoform in the other wasp venoms.
  5. ncbi Elevated basal serum tryptase and hymenoptera venom allergy: relation to severity of sting reactions and to safety and efficacy of venom immunotherapy
    G Haeberli
    Department of Medicine, Spital Bern Ziegler, Bern, Switzerland
    Clin Exp Allergy 33:1216-20. 2003
    ..Mastocytosis and/or elevated basal serum tryptase may be associated with severe anaphylaxis...
  6. ncbi Negative regulation of prophenoloxidase (proPO) activation by a clip-domain serine proteinase homolog (SPH) from endoparasitoid venom
    Guangmei Zhang
    Insect Molecular Biology Laboratory, Plant and Pest Science, Waite Campus, University of Adelaide, Glen Osmond, SA 5064, Australia
    Insect Biochem Mol Biol 34:477-83. 2004
    ..sexta proPO, PAP-1, and SPHs were impaired by this venom protein. A similar strategy might be employed by C. rubecula to negatively impact the proPO activation reaction in its natural host...
  7. ncbi Hymenoptera venom allergy: analysis of double positivity to honey bee and Vespula venom by estimation of IgE antibodies to species-specific major allergens Api m1 and Ves v5
    U R Muller
    Spital Bern Ziegler, Internal Medicine, Switzerland
    Allergy 64:543-8. 2009
    ..In patients with hymenoptera venom allergy diagnostic tests are often positive with honey bee and Vespula venom causing problems in selection of venoms for immunotherapy...
  8. ncbi Structure of recombinant Ves v 2 at 2.0 Angstrom resolution: structural analysis of an allergenic hyaluronidase from wasp venom
    Lars K Skov
    Biostructural Research, Department of Medicinal Chemistry, The Danish University of Pharmaceutical Sciences, Universitetsparken 2, DK 2100, Denmark
    Acta Crystallogr D Biol Crystallogr 62:595-604. 2006
    ..The analysis suggests that the harboured allergic IgE-mediated cross-reactivity between Ves v 2 and the allergen from D. maculata is much higher than that between Ves v 2 and the allergen from A. mellifera...
  9. pmc Expression of immune-response genes in lepidopteran host is suppressed by venom from an endoparasitoid, Pteromalus puparum
    Qi Fang
    State Key Laboratory of Rice Biology and Key Laboratory of Molecular Biology of Crop Pathogens and Insects of Ministry of Agriculture, Institute of Insect Sciences, Zhejiang University, Hangzhou 310029, China
    BMC Genomics 11:484. 2010
    ..In this study, we tested our hypothesis that P. puparum venom influences host gene expression in the two main immunity-conferring tissues, hemocytes and fat body...
  10. ncbi The basophil activation test in the diagnosis of allergy: technical issues and critical factors
    G J Sturm
    Department of Dermatology, Medical University of Graz, Austria
    Allergy 64:1319-26. 2009
    ..Nevertheless, several pitfalls have to be considered and outcomes may differ because of diverse in-house protocols and commercially available kits. We aimed to identify the factors that may influence results of the CD63-based BAT...
  11. ncbi Identification by immunoblot of venom glycoproteins displaying immunoglobulin E-binding N-glycans as cross-reactive allergens in honeybee and yellow jacket venom
    W Hemmer
    FAZ Floridsdorf Allergy Centre, Vienna, Austria
    Clin Exp Allergy 34:460-9. 2004
    ..As these antibodies possibly have low clinical relevance they may be misleading in the diagnosis of venom allergy...
  12. ncbi Identification of proteins from venom of the paralytic spider wasp, Cyphononyx dorsalis
    Tsuyoshi Yamamoto
    Graduate School of Science, Nagoya University, Furo cho, Chikusa, Nagoya 464 8602, Japan
    Insect Biochem Mol Biol 37:278-86. 2007
    ..coli were purified and used for bioassay. The results showed that the arginine kinase-like protein exhibited paralytic activity against spiders with the same characteristic symptoms as the crude venom...
  13. ncbi Specific immunotherapy using Hymenoptera venom: systematic review
    Alexandra Sayuri Watanabe
    Universidade de Sao Paulo, Sao Paulo, Brazil
    Sao Paulo Med J 128:30-7. 2010
    ..The aim of this study was to review the literature to assess the effects of venom immunotherapy among patients presenting severe reactions after Hymenoptera stings...
  14. ncbi Deadly venom of Asobara japonica parasitoid needs ovarian antidote to regulate host physiology
    A D N Mabiala-Moundoungou
    Laboratoire de Biologie des Entomophages, EA 3900 BioPI, Universite de Picardie Jules Verne, 33 rue Saint Leu, 80039 Amiens Cedex, France
    J Insect Physiol 56:35-41. 2010
    ..These results also demonstrate that A. japonica secretions from both venom gland and ovary are required to regulate synergistically the host physiology for the success of the parasitoid...
  15. ncbi Identification of an aspartylglucosaminidase-like protein in the venom of the parasitic wasp Asobara tabida (Hymenoptera: Braconidae)
    S J M Moreau
    Laboratoire de Biologie des Entomophages, Universite de Picardie Jules Verne, 33 rue Saint Leu, 80039 Amiens Cedex, France
    Insect Biochem Mol Biol 34:485-92. 2004
    ..These results constitute the first description of an AGA-like protein in an insect venom and are discussed with respect to the knowledge acquired on lysosomal and venom enzymes...
  16. pmc Extracellular superoxide dismutase in insects: characterization, function, and interspecific variation in parasitoid wasp venom
    Dominique Colinet
    Evolution and Specificity of Multitrophic Interactions, UMR 1301 Biotic Interactions and Plant Health, Institut National de la Recherche Agronomique, INRA PACA, Sophia Antipolis 06903, France
    J Biol Chem 286:40110-21. 2011
    ....
  17. ncbi Reassessing the role of hyaluronidase in yellow jacket venom allergy
    Chunsheng Jin
    Department of Chemistry, University of Natural Resources and Applied Life Sciences, Vienna, Austria
    J Allergy Clin Immunol 125:184-90.e1. 2010
    ..It shows 50% homology with the hyaluronidase from honeybee venom, Api m 2. Recently, IgE binding to YJ-HYA and cross-reactivity with Api m 2 has been shown to be due to cross-reactive carbohydrate determinants (CCDs)...
  18. ncbi Dissecting cross-reactivity in hymenoptera venom allergy by circumvention of alpha-1,3-core fucosylation
    Henning Seismann
    Institute of Biochemistry and Molecular Biology, University of Hamburg, Hamburg, Germany
    Mol Immunol 47:799-808. 2010
    ..These findings show that the use of recombinant molecules devoid of CCDs represents a novel strategy with major implications for diagnostic and therapeutic approaches...
  19. ncbi Direct injection of venom by a predatory wasp into cockroach brain
    Gal Haspel
    Zlotowski Center for Neuroscience and Department of Life Sciences, Ben Gurion University, Beer Sheva, Israel
    J Neurobiol 56:287-92. 2003
    ..To our knowledge, this is the first direct evidence documenting targeted delivery of venom by a predator into the brain of its prey...
  20. ncbi Recombinant allergens with reduced allergenicity but retaining immunogenicity of the natural allergens: hybrids of yellow jacket and paper wasp venom allergen antigen 5s
    T P King
    Rockefeller University, New York, NY 10021, USA
    J Immunol 166:6057-65. 2001
    ..Our findings suggest that hybrids represent a useful approach to map the discontinuous B cell epitope-containing regions of proteins. They also suggest that Ag 5 hybrids may be useful immunotherapeutic reagents in man...
  21. ncbi Identification, recombinant expression, and characterization of the 100 kDa high molecular weight Hymenoptera venom allergens Api m 5 and Ves v 3
    Simon Blank
    Department of Chemistry, Institute of Biochemistry and Molecular Biology, University of Hamburg, Germany
    J Immunol 184:5403-13. 2010
    ..Moreover, the patient IgE reactivity together with the cellular activation demonstrates for the first time the relevance of high m.w. allergens in the context of hymenoptera venom allergy...
  22. ncbi Structural and immunological characterization of the N-glycans from the major yellow jacket allergen Ves v 2: the N-glycan structures are needed for the human antibody recognition
    Ulla Seppälä
    Vaccine Research and Discovery, ALK ABELLO, Boge Allé 6 8, 2970 Horsholm, Denmark
    Mol Immunol 46:2014-21. 2009
    ..The occurrences of carbohydrate-specific antibodies against nVes v 2, however, suggest that non-mammalian glycan structures as in nVes v 2 may provide a link between T cells and other effector cells in allergic responses...
  23. ncbi Structural and immunological aspects of Polybia scutellaris Antigen 5
    Maria L Pirpignani
    Instituto de Química y Fisicoquímica Biológicas UBA CONICET, Junin 956, Universidad de Buenos Aires, Buenos Aires, Argentina
    Arch Biochem Biophys 407:224-30. 2002
    ..Moreover, results suggest that the protein-a new member of an extracellular protein superfamily-could be a good candidate for immunotherapy related to vespid allergy...
  24. ncbi Molecular cloning and expression in Pichia pastoris of a hypoallergenic antigen 5
    Sabrina E Vinzón
    Departamento de Quimica Biologica, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Instituto de Quimica y Fisicoquimica Biologicas, Junin 956 1113 Buenos Aires, Argentina
    Protein Expr Purif 73:23-30. 2010
    ..In conclusion, a novel protocol for the recombinant expression of Poly s 5 in P. pastoris was designed thus bringing about a high yield of the protein useful for clinical and scientific purposes...
  25. ncbi The first report of kininogen from invertebrates
    Zuohong Zhou
    Key Laboratory of Microbiological Engineering of Agricultural Environment, Ministry of Agriculture, Life Sciences College of Nanjing Agricultural University, Nanjing, Jiangsu 210095, China
    Biochem Biophys Res Commun 347:1099-102. 2006
    ..Several bradykinin-like peptides, vespakinins, have been found in wasp venoms since 1970s, but the mode of biosynthesis of these peptides is unknown...
  26. ncbi An anticoagulant serine protease from the wasp venom of Vespa magnifica
    Junyou Han
    Biotoxin Units of Key Laboratories of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, China
    Toxicon 51:914-22. 2008
    ..Magnvesin shares 52% identity with allergen serine protease from the wasp Polistes dominulus. Magnvesin exerted its anti-coagulant function by hydrolyzing coagulant factors TF, VII, VIII, IX and X...
  27. ncbi The mastoparanogen from wasp
    Xueqing Xu
    Biotoxin Units of Key Laboratories of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, China
    Peptides 27:3053-7. 2006
    ..The glycine at the tetradecapeptide end is the donator of -NH(4) for the amidation of the leucine at the C-terminal. As far as we know, this is the first report of the precursor of animal mastoparan...
  28. ncbi Asymptomatic sensitization to hymenoptera venom is related to total immunoglobulin E levels
    Gunter J Sturm
    Department of Dermatology, Division of Environmental Dermatology and Venerology, Medical University of Graz, Graz, Austria
    Int Arch Allergy Immunol 148:261-4. 2009
    ..The detection of specific serum immunoglobulin E (sIgE) to Hymenoptera venoms is an established diagnostic tool to diagnose insect venom hypersensitivity. However, the specificity of sIgE detection is a debated issue...
  29. ncbi Wasp parasitoid disruption of host development: implications for new biologically based strategies for insect control
    Nancy E Beckage
    Department of Entomology, University of California Riverside, Riverside, California 92521, USA
    Annu Rev Entomol 49:299-330. 2004
    ..Possibilities for using regulatory molecules produced by the parasitoid or its products that would be potentially useful in developing new, environmentally safe insect control agents are discussed...
  30. pmc Insights into the venom composition of the ectoparasitoid wasp Nasonia vitripennis from bioinformatic and proteomic studies
    D C de Graaf
    Laboratory of Zoophysiology, Ghent University, Ghent, Belgium
    Insect Mol Biol 19:11-26. 2010
    ..The present study contributes greatly to the understanding of the biological diversity of the venom of parasitoid wasps at the molecular level...
  31. ncbi In vitro hymenoptera venom allergy diagnosis: improved by screening for cross-reactive carbohydrate determinants and reciprocal inhibition
    U Jappe
    Department of Dermatology and Venereology, University of Heidelberg, Heidelberg, Germany
    Allergy 61:1220-9. 2006
    ..The aim of this study was to clarify the cause and relation of the cross-reactivity in patients with insect venom allergy...
  32. ncbi A phospholipase A1 platelet activator from the wasp venom of Vespa magnifica (Smith)
    Hailong Yang
    Biotoxin Units of Key Laboratories of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, China
    Toxicon 51:289-96. 2008
    ..Magnifin can activate platelet aggregation and induce thrombosis in vivo. The current results proved that PLA(1) in wasp venom could be contributable to aortic thrombosis after massive wasp stings...
  33. pmc Display of wasp venom allergens on the cell surface of Saccharomyces cerevisiae
    Irina Borodina
    Dermato Allergological Dept K, CUH Gentofte, Rigshospitalet Dept 7551, Blegdamsvej 9, 2100 København Ø, Denmark
    Microb Cell Fact 9:74. 2010
    ..We chose to use the major allergens from the common wasp Vespula vulgaris venom: phospholipase A1, hyaluronidase and antigen 5 as the model...
  34. ncbi Hymenoptera venom allergy
    Bernhard Przybilla
    Klinik und Poliklinik fur Dermatologie und Allergologie, AllergieZentrum, Ludwig Maximilians Universitat, Munich, Germany
    J Dtsch Dermatol Ges 8:114-27; quiz 128-30. 2010
    ....
  35. ncbi Parasitism of Pieris rapae (Lepidoptera: Pieridae) by a pupal endoparasitoid, Pteromalus puparum (Hymenoptera: Pteromalidae): effects of parasitization and venom on host hemocytes
    Jun Cai
    Department of Micriobiology, Life Sciences College, Nankai University, Tianjin, China
    J Insect Physiol 50:315-22. 2004
    ..The results suggested that venom of P. puparum could actively suppress the hemocyte immune response of its host, but not by destroying the host hemocyte cytoskeleton...
  36. pmc Allergen-specific immunosuppression by mucosal treatment with recombinant Ves v 5, a major allergen of Vespula vulgaris venom, in a murine model of wasp venom allergy
    Birgit Winkler
    Department of Pathophysiology, University of Vienna, Austria
    Immunology 110:376-85. 2003
    ....
  37. ncbi Cross-reactive carbohydrate determinants strongly affect the results of the basophil activation test in hymenoptera-venom allergy
    M Mertens
    Department of Dermatology, University of Munster, Von Esmarch Strasse 58, Munster, Germany
    Clin Exp Allergy 40:1333-45. 2010
    ..This phenomenon is mainly caused by specific IgE (sIgE) against cross-reactive carbohydrate determinants (CCD). Whether or not these antibodies can induce clinical symptoms is a longstanding debate...
  38. pmc Mechanism of the cell-penetrating peptide transportan 10 permeation of lipid bilayers
    Lindsay E Yandek
    Department of Chemistry and Biochemistry, University of North Carolina Wilmington, Wilmington, North Carolina 28403, USA
    Biophys J 92:2434-44. 2007
    ....
  39. ncbi Major venom allergen of yellow jackets, Ves v 5: structural characterization of a pathogenesis-related protein superfamily
    A Henriksen
    Protein Structure Group, Department of Chemistry, University of Copenhagen, Copenhagen, Denmark
    Proteins 45:438-48. 2001
    ..The structure of Ves v 5 allows a detailed analysis of the epitopes that may participate in antigenic cross-reactivity, findings that are useful for the development of a vaccine for treatment of insect allergy...
  40. ncbi Two novel proteins expressed by the venom glands of Apis mellifera and Nasonia vitripennis share an ancient C1q-like domain
    D C de Graaf
    Laboratory of Zoophysiology, Ghent University, Ghent, Belgium
    Insect Mol Biol 19:1-10. 2010
    ..A preliminary test using recombinant proteins failed to demonstrate Am_C1q-VP-specific immunoglobulin E recognition by serum from patients with a documented severe bee venom allergy...
  41. ncbi Venom from the ectoparasitic wasp Nasonia vitripennis increases Na+ influx and activates phospholipase C and phospholipase A2 dependent signal transduction pathways in cultured insect cells
    David B Rivers
    Department of Biology, Loyola College in Maryland, 4501 North Charles Street, Baltimore, MD 21210, USA
    Toxicon 40:9-21. 2002
    ..A possible mode of action for venom from N. vitripennis requiring dual activation of PLC and PLA2 is discussed and compared to the pathways known to be activated by mastoparan...
  42. ncbi Parasitism of Lacanobia oleracea (Lepidoptera) by the ectoparasitoid, Eulophus pennicornis, is associated with a reduction in host haemolymph phenoloxidase activity
    E H Richards
    Central Science Laboratory, Sand Hutton, York, UK
    Comp Biochem Physiol B Biochem Mol Biol 127:289-98. 2000
    ..The results are discussed with reference to the survival advantages of suppressing the activity of this host enzyme, and to the possible source(s) of putative suppressive factors...
  43. ncbi Localization of intracellular calcium release in cells injured by venom from the ectoparasitoid Nasonia vitripennis (Walker) (Hymenoptera: Pteromalidae) and dependence of calcium mobilization on G-protein activation
    David B Rivers
    Department of Biology, Loyola College in Maryland, 4501 North Charles Street, Baltimore, MD 21210, USA
    J Insect Physiol 51:149-60. 2005
    ..Mobilization of calcium in this fashion could stimulate cAMP formation, and subsequently promote calcium release from NAADP-sensitive stores...
  44. ncbi A gamma-glutamyl transpeptidase of Aphidius ervi venom induces apoptosis in the ovaries of host aphids
    Patrizia Falabella
    Dipartimento di Biologia, Difesa e Biotecnologie Agro Forestali, Universita della Basilicata, Potenza, Italy
    Insect Biochem Mol Biol 37:453-65. 2007
    ..ervi and in the chromatographic fractions containing Ae-gamma-GT. Thus, we suggest that this venom protein may induce apoptosis in the host ovarioles by generating an alteration of the GSH metabolism and a consequent oxidative stress...
  45. ncbi Variation of success of Leptopilina boulardi in Drosophila yakuba: the mechanisms explored
    Aurore Dubuffet
    Universite Francois Rabelais, IRBI, Parc Grandmont, 37200 Tours, France
    Dev Comp Immunol 32:597-602. 2008
    ..melanogaster immune system as well as the role of parasitoid venoms in intra-specific variation of parasitoid virulence...
  46. ncbi Prevalence and clinical relevance of specific immunoglobulin E to pollen caused by sting- induced specific immunoglobulin E to cross-reacting carbohydrate determinants in Hymenoptera venoms
    A M Kochuyt
    Department of Internal Medicine, Division of Allergy and Clinical Immunology, University Hospital Gasthuisberg, Leuven, Belgium
    Clin Exp Allergy 35:441-7. 2005
    ..sIgE to such cross-reacting CD (CCD) are believed to have little or no biological activity and thus may cause misdiagnosis of pollen sensitization after a sting...
  47. ncbi Hydrolase activity in the venom of the pupal endoparasitic wasp, Pimpla hypochondriaca
    M P Dani
    Central Science Laboratory, Sand Hutton, York YO41 1LZ, UK
    Comp Biochem Physiol B Biochem Mol Biol 141:373-81. 2005
    ..oleracea haemocytes. The results suggest that, despite the relatively high levels of acid phosphatase activity in venom, venom acid phosphatase plays no role in the antihaemocytic activity of P. hypochondriaca venom in vitro...
  48. ncbi A serine proteinase homolog venom protein from an endoparasitoid wasp inhibits melanization of the host hemolymph
    Sassan Asgari
    Insect Molecular Biology Lab, Plant and Pest Science, Waite Campus, University of Adelaide, Glen Osmond, SA 5064, Australia
    Insect Biochem Mol Biol 33:1017-24. 2003
    ..The data presented here indicate that the protein interferes with the proteolytic cascade, which under normal circumstances leads to the activation of proPO and melanin formation...
  49. ncbi A calreticulin-like protein from endoparasitoid venom fluid is involved in host hemocyte inactivation
    Guangmei Zhang
    Insect Molecular Biology Laboratory, Plant and Pest Science, Waite Campus, University of Adelaide, Glen Osmond, SA 5064, Australia
    Dev Comp Immunol 30:756-64. 2006
    ..It is possible that the protein might function as an antagonist competing for binding sites with the host hemocyte calreticulin, which mediates early-encapsulation reactions...
  50. ncbi Venom proteins from polydnavirus-producing endoparasitoids: their role in host-parasite interactions
    Sassan Asgari
    School of Integrative Biology, University of Queensland, St Lucia, Queensland, Australia
    Arch Insect Biochem Physiol 61:146-56. 2006
    ..rubecula venom proteins in host-parasitoid interactions...
  51. ncbi Bacterial fermentation of recombinant major wasp allergen Antigen 5 using oxygen limiting growth conditions improves yield and quality of inclusion bodies
    Stefanie Kischnick
    Allergopharma Joachim Ganzer KG, Reinbek, Germany
    Protein Expr Purif 47:621-8. 2006
    ..This has an influence on inclusion body formation, which in turn influences the renaturation rate and absolute product yield. This might also be true for other recombinant proteins that accumulate as inclusion bodies in Escherichia coli...
  52. ncbi Parasitoid wasp uses a venom cocktail injected into the brain to manipulate the behavior and metabolism of its cockroach prey
    Ram Gal
    Department of Life Sciences, Ben Gurion University, Beer Sheva, Israel
    Arch Insect Biochem Physiol 60:198-208. 2005
    ..The alteration in the octopaminergic neurons' activity could be one of the mechanisms by which the venom modulates the escape circuit in the cockroach's central nervous system and metabolism in the peripheral system...
  53. ncbi Towards a comprehensive view of the primary structure of venom proteins from the parasitoid wasp Pimpla hypochondriaca
    Neil M Parkinson
    Central Science Laboratory, Sand Hutton, York YO41 1LZ, UK
    Insect Biochem Mol Biol 34:565-71. 2004
    ..The random sequencing approach has provided a rapid means of determining the primary structure of the majority of Pimpla hypochondriaca venom proteins...
  54. ncbi Characterization of phenoloxidase activity in venom from the ectoparasitoid Nasonia vitripennis (Walker) (Hymenoptera: Pteromalidae)
    Michael Abt
    Department of Biology, Loyola College, 4501 North Charles Street, Baltimore, MD 21210, USA
    J Invertebr Pathol 94:108-18. 2007
    ..These observations collectively argue that wasp venom PO is unique from that of the fly hosts, and that the venom enzyme is critical in the intoxication pathway leading to cell death...
  55. ncbi Parasitoid wasp sting: a cocktail of GABA, taurine, and beta-alanine opens chloride channels for central synaptic block and transient paralysis of a cockroach host
    Eugene L Moore
    Department of Entomology, University of California, Riverside, 92521, USA
    J Neurobiol 66:811-20. 2006
    ..Together these data demonstrate that Ampulex utilizes GABAergic chloride channel activation as a strategy for central synaptic block to induce transient and focal leg paralysis in its host...
  56. ncbi A proteomic study of the major allergens from yellow jacket venoms
    Daniel Kolarich
    Biochemistry Division, Department of Chemistry, University of Natural Resources and Applied Life Sciences BOKU, Vienna, Austria
    Proteomics 7:1615-23. 2007
    ..vulgaris, germanica, maculifrons, pensylvanica, flavopilosa and squamosa revealed the latter as a taxonomic outlier and led to the discovery of several not previously reported amino acid differences...
  57. ncbi Advances and prospects on biosynthesis, structures and functions of venom proteins from parasitic wasps
    S J M Moreau
    UMR CNRS 6035, Institut de Recherche sur la Biologie de l Insecte, Universite Francois Rabelais, Avenue Monge, Parc Grandmont, 37200 Tours, France
    Insect Biochem Mol Biol 35:1209-23. 2005
    ....
  58. ncbi A novel venom peptide from an endoparasitoid wasp is required for expression of polydnavirus genes in host hemocytes
    Guangmei Zhang
    Insect Molecular Biology Laboratory, Department of Plant and Pest Science, Waite Campus, University of Adelaide, Glen Osmond SA 5064, Australia
    J Biol Chem 279:41580-5. 2004
    ..The peptide consists of 14 amino acids with a molecular mass of 1598 Da. In the absence of Vn1.5 or total venom proteins, CrBV genes are not expressed in host cells and did not cause inactivation of host hemocytes...
  59. ncbi New developments in the diagnosis and treatment of hymenoptera venom allergy
    U R Muller
    Medizinische Klinik, Zieglerspital, Bern, Schweiz
    Int Arch Allergy Immunol 124:447-53. 2001
    ..While most patients are still fully protected 1 year after discontinuation of therapy, relapses may occur in up to 20% of patients reexposed many years after treatment. Various risk factors for such relapses have been identified...
  60. ncbi A venom metalloproteinase from the parasitic wasp Eulophus pennicornis is toxic towards its host, tomato moth (Lacanobia oleracae)
    D R G Price
    University of Durham, UK
    Insect Mol Biol 18:195-202. 2009
    ..EpMP3 is expressed specifically in venom glands. These results suggest that EpMP3 is a functional component of Eulophus venom, which is able to manipulate host development...
  61. ncbi A serpin from the parasitoid wasp Leptopilina boulardi targets the Drosophila phenoloxidase cascade
    Dominique Colinet
    Institut National de la Recherche Agronomique, INRA, UMR 1301, France
    Dev Comp Immunol 33:681-9. 2009
    ..Altogether, our results identify the first serpin used as a virulence factor by a parasitoid wasp and show that it disrupts the activation pathway of the PO in the Drosophila host...
  62. ncbi Isolation and characterization of an immunosuppressive protein from venom of the pupa-specific endoparasitoid Pteromalus puparum
    Ma Li Wu
    State Key Laboratory of Rice Biology, Institute of Insect Sciences, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou 310029, China
    J Invertebr Pathol 99:186-91. 2008
    ..It is suggested that this protein is an actual component of P. puparum crude venom as host cellular-immune suppressive factor...
  63. ncbi Biochemical isolation of an insect haemocyte anti-aggregation protein from the venom of the endoparasitic wasp, Pimpla hypochondriaca, and identification of its gene
    Elaine H Richards
    Central Science Laboratory, Sand Hutton, York Y041 1LZ, UK
    J Insect Physiol 54:1041-9. 2008
    ..Furthermore, its gene has been identified as vpr3. The work is presented within the context of the role of P. hypochondriaca venom and the isolated protein in host immune suppression...
  64. ncbi A parasitoid wasp manipulates the drive for walking of its cockroach prey
    Ram Gal
    Zlotowski Center for Neuroscience, Ben Gurion University of the Negev, PO Box 653, Be er Sheva 84105, Israel
    Curr Biol 18:877-82. 2008
    ..We thus report that the venom, rather than decreasing overall arousal, manipulates neuronal centers within the cerebral ganglia that are specifically involved in the initiation and maintenance of walking...
  65. ncbi The constituents of Microctonus sp. parasitoid venoms
    A M Crawford
    AgResearch Invermay Agricultural Centre, Puddle Alley, Private Bag 50034, Mosgiel, New Zealand
    Insect Mol Biol 17:313-24. 2008
    ..hyperodae being found in M. aethiopoides. Pyrosequencing should provide a valuable new method for rapidly sampling transcripts from a wide range of specialised insect tissues...
  66. ncbi A venom protein from the endoparasitoid wasp Pimpla hypochondriaca is similar to snake venom reprolysin-type metalloproteases
    Neil Parkinson
    Central Science Laboratory, Sand Hutton, York YO41 1LZ, UK
    J Invertebr Pathol 79:129-31. 2002
  67. ncbi Interaction and structure induction of cell-penetrating peptides in the presence of phospholipid vesicles
    M Magzoub
    Department of Biochemistry and Biophysics, Arrhenius Labratories, Stockholm University, Sweden
    Biochim Biophys Acta 1512:77-89. 2001
    ..We conclude that the exact nature of any secondary structure induced by the membrane model systems is not directly correlated with the common transport property of these translocating peptides...
  68. ncbi Bee, wasp and ant venomics pave the way for a component-resolved diagnosis of sting allergy
    Dirk C de Graaf
    Laboratory of Zoophysiology, Ghent University, B 9000 Ghent, Belgium
    J Proteomics 72:145-54. 2009
    ..The information the physician will get from such a single run will largely exceed the output from current IgE capturing tools using whole venom preparations...
  69. ncbi Hymenoptera venom allergens
    Donald R Hoffman
    Department of Pathology and Laboratory Medicine, Brody School of Medicine at East Carolina University, Greenville, NC, USA
    Clin Rev Allergy Immunol 30:109-28. 2006
    ..Examples of the use of these techniques with venom proteins are presented...
  70. ncbi Isolation, cloning, and characterization of new chitinase stored in active form in chitin-lined venom reservoir
    A Krishnan
    Graduate Center for Toxicology, University of Kentucky, Lexington 40506
    J Biol Chem 269:20971-6. 1994
    ..The kinetic properties of the 52-kDa wasp chitinase were quite distinct from Serratia marcescens chitinase for both catalytic rate and substrate inhibition...
  71. ncbi Molecular and biochemical analysis of an aspartylglucosaminidase from the venom of the parasitoid wasp Asobara tabida (Hymenoptera: Braconidae)
    S Vinchon
    Laboratoire de Biologie des Entomophages, EA3900 BioPI, Universite de Picardie Jules Verne, 33 rue Saint Leu, 80039 Amiens Cedex, France
    Insect Biochem Mol Biol 40:38-48. 2010
    ..The study of this enzyme may allow a better understanding of the functional evolution of venom enzymes in hymenopteran parasitoids...
  72. ncbi Venom of the egg-larval parasitoid Chelonus inanitus is a complex mixture and has multiple biological effects
    Martha Kaeslin
    Institute of Cell Biology, University of Berne, Baltzerstrasse 4, CH 3012 Berne, Switzerland
    J Insect Physiol 56:686-94. 2010
    ..The multifunctionality of the venom might thus be essential in enabling parasitization of all stages of host eggs...
  73. ncbi Isolation and characterization of a novel venom protein from an endoparasitoid, Cotesia rubecula (Hym: Braconidae)
    Sassan Asgari
    Department of Applied and Molecular Ecology, The University of Adelaide, Glen Osmond, South Australia
    Arch Insect Biochem Physiol 53:92-100. 2003
    ..The coding region for Vn4.6 is located upstream in the opposite direction of a gene coding for a C. rubecula PDV-protein (Crp32)...
  74. ncbi Variation of Leptopilina boulardi success in Drosophila hosts: what is inside the black box?
    A Dubuffet
    Institute of Integrative and Comparative Biology, Faculty of Biological Sciences, University of Leeds, United Kingdom
    Adv Parasitol 70:147-88. 2009
    ..This chapter focuses on the physiological and molecular aspects of L. boulardi interactions with two Drosophila host species, while most of the evolutionary hypotheses and models are presented in Chapter 11 of Dupas et al...
  75. ncbi A new form of arthropod phenoloxidase is abundant in venom of the parasitoid wasp Pimpla hypochondriaca
    N Parkinson
    Central Science Laboratory, Sand Hutton, YO41 1LZ, York, UK
    Insect Biochem Mol Biol 31:57-63. 2001
    ..A novel means of host immune suppression, mediated by the unregulated activity of venom PO in the haemocoel, is proposed...
  76. ncbi Molecular cloning and characterization of acid phosphatase in venom of the endoparasitoid wasp Pteromalus puparum (Hymenoptera: Pteromalidae)
    Jia Ying Zhu
    State Key Laboratory of Rice Biology, Institute of Insect Sciences, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou, China
    Toxicon 51:1391-9. 2008
    ..Compared to the mRNA expression, a time-course-related enzyme activity in an individual venom apparatus was also found...
  77. ncbi Cargo delivery kinetics of cell-penetrating peptides
    M Hällbrink
    Department of Neurochemistry and Neurotoxicology, Arrhenius Laboratories, Stockholm University, Sweden
    Biochim Biophys Acta 1515:101-9. 2001
    ..In summary, the yield and kinetics of cellular cargo delivery for four different CPPs has been quantitatively characterized...
  78. ncbi Vespid chemotactic peptide precursor from the wasp, Vespa magnifica (Smith)
    Haining Yu
    College of Life Sciences School of Hebei Normal University, Shijiazhuang, Hebei 050016, China
    Toxicon 50:377-82. 2007
    ..The current results suggested that the biosynthesis mode of VCP was different from that of temporin AMP, even though the two mature peptides were similar in many ways. It is also the first report about VCP precursor from wasp venom...
  79. ncbi Morphology and ultrastructure of the venom apparatus in the endoparasitic wasp Pteromalus puparum (Hymenoptera: Pteromalidae)
    Jia Ying Zhu
    State Key Laboratory of Rice Biology, Institute of Insect Sciences, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou 310029, China
    Micron 39:926-33. 2008
    ..The venom proteins are first mainly produced in the secretory unit of venom gland, then drained to the lumen through the end apparatus, and are finally collected and stored in the venom reservoir...
  80. ncbi Two families of antimicrobial peptides from wasp (Vespa magnifica) venom
    Xueqing Xu
    Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China
    Toxicon 47:249-53. 2006
    ..These peptides show antimicrobial activities against bacteria and fungi. However, they show little hemolytic activity against human blood red cells...
  81. ncbi The basophil activation test in wasp venom allergy: sensitivity, specificity and monitoring specific immunotherapy
    S M Erdmann
    Department of Dermatology and Allergology, University Hospital of Aachen, Aachen, Germany
    Allergy 59:1102-9. 2004
    ..Furthermore, to date, no in vitro test exists to monitor successful specific immunotherapy (SIT) with wasp venom. Therefore, the potentially harmful sting challenge is still recommended...
  82. ncbi Characterization of the major allergens purified from the venom of the paper wasp Polistes gallicus
    Barbara Pantera
    Department of Biochemical Sciences, University of Florence, Viale Morgagni 50, 50134 Florence, Italy
    Biochim Biophys Acta 1623:72-81. 2003
    ....
  83. ncbi Differential membrane perturbation caused by the cell penetrating peptide Tp10 depending on attached cargo
    Elsa Bárány-Wallje
    Department of Biochemistry and Biophysics, The Arrhenius Laboratories, Stockholm University, S 10691 Stockholm, Sweden
    FEBS Lett 581:2389-93. 2007
    ..The results suggest that direct membrane effects may cause membrane translocation of Tp10 alone and of smaller complexes, whereas these effects do not contribute for larger cargoes...
  84. doi [Hymenoptera venom allergy. Life-threatening but curable]
    B Przybilla
    Klinik und Poliklinik fur Dermatologie und Allergologie, Ludwig Maximilians Universitat, Munchen
    Hautarzt 59:182-3. 2008
  85. ncbi [Hymenoptera stings]
    Krzysztof Ciszowski
    Oddzial Kliniczny Toksykologii i Chorób Srodowiskowych WSS im L Rydygiera w Krakowie
    Przegl Lek 64:282-9. 2007
    ..In the present review types of reaction after hymenoptera stings were described with special interest of anaphylactic and toxic reactions as well as therapeutic management after stings...
  86. ncbi Fatal anaphylactic sting reaction in a patient with mastocytosis
    N Wagner
    Hautklinik, Klinikum Darmstadt, Darmstadt, Deutschland
    Int Arch Allergy Immunol 146:162-3. 2008
    ..However, no criteria have been established in order to allow a selection of mastocytosis patients eligible for such a 'prophylactic' VIT...
  87. ncbi European Polistes venom allergy
    M G Severino
    Allergy Clinic, Nuovo Ospedale San Giovanni di Dio Florence, Florence, Italy
    Allergy 61:860-3. 2006
    ..Moreover, we found a high rate of cross-reactivity between P. dominulus and P. gallicus. To conclude, P. dominulus and/or P. gallicus venoms are necessary for diagnosis and therefore in the therapy of European patients...
  88. ncbi Outcome survey of insect venom allergic patients with venom immunotherapy in a rural population
    Alexander Roesch
    Department of Dermatology, Regensburg University Hospital, Regensburg, Germany
    J Dtsch Dermatol Ges 6:292-7. 2008
    ..Hymenoptera venom anaphylaxis is a frightening event that affects physical and psychical functioning...
  89. ncbi Hypersensitivity to Vespula and Polistes: can we tell the primary sensitization from the clinical history?
    A J Pérez Pimiento
    Allergy Department Hospital Universitario Puerta de Hierro Madrid Spain
    Allergol Immunopathol (Madr) 35:225-7. 2007
    To study the relationship between the primary sensitization to wasp venoms and the geographical and seasonal circumstances of the anaphylaxis-induced sting.
  90. ncbi Implications of venom hypersensitivity for a deploying soldier
    Karla L Davis
    Department of Allergy and Immunology, Walter Reed Army Medical Center, Washington, DC 20307, USA
    Mil Med 172:544-7. 2007
    ..This case demonstrates that, with proper coordination and appropriate risk assessment, continuation of complex medical care, such as VIT, can be supported in a combat zone...
  91. doi Prevalence and alternative therapy methods for bee and wasp allergy in Van
    K Onbasi
    Department of Internal Medicine, Yuzuncu Yil University Hospital, Iskele Cad Altingö l Bloklari, A Blok, no 84, Daire 10 65040 Van, Turkey
    Allergy 63:246-7. 2008
  92. ncbi Expansion of circulating Foxp3+)D25bright CD4+ T cells during specific venom immunotherapy
    M C Pereira-Santos
    Unidade de Imunologia Clinica, Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal
    Clin Exp Allergy 38:291-7. 2008
    ..Regulatory T cells are thought to play an important role in allergic diseases and tolerance induction during specific immunotherapy...
  93. ncbi Safety of specific immunotherapy using a four-hour ultra-rush induction scheme in bee and wasp allergy
    A Roll
    Allergy Unit, Department of Dermatology, University Hospital, Zurich, Switzerland
    J Investig Allergol Clin Immunol 16:79-85. 2006
    ..L. Mueller classification, concentration of venom inducing positive skin tests, level of specific IgE, serum tryptase concentration, and hymenoptera venom used for treatment...
  94. ncbi [Insect venom allergy. Removing the sting of killer bees!]
    B Przybilla
    ,
    MMW Fortschr Med 143:41-4. 2001
    ..If, however, the individual patient is at a particular risk, hyposensitization must be continued for a longer period, possibly even life-long...
  95. ncbi Multiple organ dysfunction syndrome following single wasp sting
    R Rathi Sharmila
    Department of Pediatrics, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India
    Indian J Pediatr 74:1111-2. 2007
    ..We report here the clinical course of a 12 year old child who developed Multiple Organ Dysfunction Syndrome (MODS) and died after a single wasp sting...
  96. ncbi Cellular in vitro assays in the diagnosis of Hymenoptera venom allergy
    K Scherer
    Allergy Unit, Department of Dermatology, University Hospital Basel, Basel, Switzerland
    Int Arch Allergy Immunol 146:122-32. 2008
    ..Sometimes, the culprit insect remains unidentified. The usefulness of the cellular assays CAST-ELISA and Flow-CAST in the management of hymenoptera venom allergy was investigated...
  97. ncbi Long-term efficacy of venom immunotherapy
    Tomaz Hafner
    University Clinic of Respiratory and Allergic Diseases, Golnik, Slovenia
    Ann Allergy Asthma Immunol 100:162-5. 2008
    ..The long-term efficacy of venom immunotherapy (VIT) in patients who either prematurely discontinue VIT or who experience subsequent stings after discontinuation of VIT remains uncertain...
  98. ncbi Premedication with montelukast reduces local reactions of allergen immunotherapy
    Stefan Wöhrl
    Division of Immunology, Allergy and Infectious Diseases, Department of Dermatology, Medical University of Vienna, Vienna, Austria
    Int Arch Allergy Immunol 144:137-42. 2007
    ..We were interested whether pretreatment with the leukotriene antagonist montelukast would be better suited for preventing those reactions than pretreatment with the antihistamine desloratadine...
  99. ncbi [Bionomics and defensive behaviour of bees and diplopterous wasps (Hymenoptera, Apidae, Vespidae) causing venom allergies in Germany]
    V Mauss
    Zentrum für Wespenkunde, 74545, Michelfeld Gnadental
    Hautarzt 59:184, 186-93. 2008
    ..Geographical and altitudinal distribution, phenology, nest sites and foraging habitats of these species are concisely characterized. Their defensive behavior is described...
  100. ncbi Hymenoptera stings
    Kevin T FitzGerald
    Alameda East Veterinary Hospital, Denver CO 80231, USA
    Clin Tech Small Anim Pract 21:194-204. 2006
    ..Bee and wasp venoms are made up primarily of protein. Conversely, fire ant venoms are 95% alkaloids...
  101. ncbi [Cross-reactivity to honeybee and wasp venom]
    W Hemmer
    FAZ Floridsdorfer Allergiezentrum, Franz Jonas Platz 8 6, 1210, Wien
    Hautarzt 59:194-9. 2008
    ..Future in-vitro diagnosis will be markedly improved when recombinant allergens lacking CCDs become commercially available...

Research Grants9

  1. A Model System For Host-Pathogen Interactions: Drosophila And Its Parasitic Wasps
    TODD ALEXANDER SCHLENKE; Fiscal Year: 2012
    ....
  2. REGULATION OF G PROTEINS BY MASTOPARAN
    TSUTOMU HIGASHIJIMA; Fiscal Year: 1992
    ..Affinity crosslinking of MP targets in cells, measurements of MP uptake and its mechanism and the use of MP as an affinity chromatographic ligand will be included in these experiments...
  3. Role of Erythrocytes in Circulatory Control
    Randy Sprague; Fiscal Year: 2004
    ..abstract_text> ..
  4. Mechanisms of ATP Release from RBC's
    Randy Sprague; Fiscal Year: 2007
    ..abstract_text> ..
  5. IN VITRO APPROACH TO PROBLEMS OF CLINICAL ALLERGY
    David Golden; Fiscal Year: 2005
    ..We need to continue to study these patients to develop the most useful clinical guidelines. ..
  6. A cell-free system for exocytosis in the beta-cell
    SUSANNE STRAUB SHARP; Fiscal Year: 2005
    ..physiological mechanisms such as time-dependent potentiation and biphasic insulin release. The method will also allow the study of some aspects of endocytosis. ..
  7. POTASSIUM CHANNELS AND CEREBRAL HEMODYNAMICS AFTER BRAIN
    William Armstead; Fiscal Year: 2005
    ..These studies may lead to therapies for brain injured children. ..
  8. Plasminogen activators and cerebral ischemic injury
    William M Armstead; Fiscal Year: 2010
    ....