plant preparations

Summary

Summary: Material prepared from plants for medicinal purposes.

Top Publications

  1. ncbi Interaction of phytoestrogens with estrogen receptors alpha and beta (II)
    Keiko Morito
    Department of Molecular and Cellular Biology, Faculty of Pharmaceutical Sciences, Kanazawa University, Ishikawa, Japan
    Biol Pharm Bull 25:48-52. 2002
  2. ncbi Dietary flaxseed inhibits atherosclerosis in the LDL receptor-deficient mouse in part through antiproliferative and anti-inflammatory actions
    Chantal M C Dupasquier
    Canadian Center for Agri food Research in Health and Medicine, St Boniface Hospital Research Center, Winnipeg, Canada
    Am J Physiol Heart Circ Physiol 293:H2394-402. 2007
  3. ncbi Effect of polyherbal formulation on experimental models of inflammatory bowel diseases
    A G Jagtap
    Department of Pharmacology, Bombay College of Pharmacy, Kalina, Santacruz E, Mumbai 400 098, India
    J Ethnopharmacol 90:195-204. 2004
  4. ncbi The effects of phytoestrogen isoflavones on bone density in women: a double-blind, randomized, placebo-controlled trial
    Charlotte Atkinson
    MRC Biostatistics Unit, Institute of Public Health, Robinson Way, Cambridge, United Kingdom
    Am J Clin Nutr 79:326-33. 2004
  5. ncbi Phyto-oestrogens and cancer
    Herman Adlercreutz
    Institute for Preventive Medicine, Nutrition, and Cancer, Folkhalsan Research Center, Division of Clinical Chemistry, University of Helsinki, Helsinki, Finland
    Lancet Oncol 3:364-73. 2002
  6. pmc Re-examining hypotheses concerning the use and knowledge of medicinal plants: a study in the Caatinga vegetation of NE Brazil
    Ulysses Paulino de Albuquerque
    Laboratório de Etnobotânica Aplicada, Área de Botânica, Departamento de Biologia, Universidade Federal Rural de Pernambuco, Rua Dom Manoel de Medeiros s n, Dois Irmãos Recife Pernambuco, 52171 030, Brasil
    J Ethnobiol Ethnomed 2:30. 2006
  7. pmc Ethnobotanical study of medicinal plants used by people in Zegie Peninsula, Northwestern Ethiopia
    Tilahun Teklehaymanot
    Endod and Other Medicinal Plants Unit, Aklilu Lemma Institute of Pathobiology, Addis Ababa University, PO Box 1176, Addis Ababa, Ethiopia
    J Ethnobiol Ethnomed 3:12. 2007
  8. ncbi Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta
    G G Kuiper
    Center for Biotechnology and Department of Medical Nutrition, Karolinska Institute, Huddinge, Sweden
    Endocrinology 139:4252-63. 1998
  9. ncbi An ethnobotanical study on the usage of wild medicinal herbs from Kopaonik Mountain (Central Serbia)
    Snezana Jarić
    Department of Ecology, The Sinisa Stanković Institute for Biological Research, University of Belgrade, Bulevar Despota Stefana 142, Belgrade, Serbia and Montenegro
    J Ethnopharmacol 111:160-75. 2007
  10. ncbi Almond consumption and cardiovascular risk factors in adults with prediabetes
    Michelle Wien
    University of Medicine and Dentistry of New Jersey, Newark, New Jersey, USA
    J Am Coll Nutr 29:189-97. 2010

Detail Information

Publications273 found, 100 shown here

  1. ncbi Interaction of phytoestrogens with estrogen receptors alpha and beta (II)
    Keiko Morito
    Department of Molecular and Cellular Biology, Faculty of Pharmaceutical Sciences, Kanazawa University, Ishikawa, Japan
    Biol Pharm Bull 25:48-52. 2002
    ..The results show that methylation or glucosidation of isoflavones generally inhibits their phytoestrogenic activities...
  2. ncbi Dietary flaxseed inhibits atherosclerosis in the LDL receptor-deficient mouse in part through antiproliferative and anti-inflammatory actions
    Chantal M C Dupasquier
    Canadian Center for Agri food Research in Health and Medicine, St Boniface Hospital Research Center, Winnipeg, Canada
    Am J Physiol Heart Circ Physiol 293:H2394-402. 2007
    ..Our results demonstrate that dietary flaxseed can inhibit atherosclerosis in the LDLrKO mouse through a reduction of circulating cholesterol levels and, at a cellular level, via antiproliferative and anti-inflammatory actions...
  3. ncbi Effect of polyherbal formulation on experimental models of inflammatory bowel diseases
    A G Jagtap
    Department of Pharmacology, Bombay College of Pharmacy, Kalina, Santacruz E, Mumbai 400 098, India
    J Ethnopharmacol 90:195-204. 2004
    ..The activity was comparable with the standard drug prednisolone. The results obtained established the efficacy of this polyherbal formulation against inflammatory bowel diseases...
  4. ncbi The effects of phytoestrogen isoflavones on bone density in women: a double-blind, randomized, placebo-controlled trial
    Charlotte Atkinson
    MRC Biostatistics Unit, Institute of Public Health, Robinson Way, Cambridge, United Kingdom
    Am J Clin Nutr 79:326-33. 2004
    ..Isoflavone phytoestrogen therapy has been proposed as a natural alternative to hormone replacement therapy (HRT). HRT has a beneficial effect on bone, but few trials in humans have investigated the effects of isoflavones on bone...
  5. ncbi Phyto-oestrogens and cancer
    Herman Adlercreutz
    Institute for Preventive Medicine, Nutrition, and Cancer, Folkhalsan Research Center, Division of Clinical Chemistry, University of Helsinki, Helsinki, Finland
    Lancet Oncol 3:364-73. 2002
    ..Whether these observed protective effects are caused by the presence of dietary phyto-oestrogens, or whether they are merely indicators of a healthy diet in general, has not been established...
  6. pmc Re-examining hypotheses concerning the use and knowledge of medicinal plants: a study in the Caatinga vegetation of NE Brazil
    Ulysses Paulino de Albuquerque
    Laboratório de Etnobotânica Aplicada, Área de Botânica, Departamento de Biologia, Universidade Federal Rural de Pernambuco, Rua Dom Manoel de Medeiros s n, Dois Irmãos Recife Pernambuco, 52171 030, Brasil
    J Ethnobiol Ethnomed 2:30. 2006
    ..However, very little information is available concerning the interaction of people with the plants of the Caatinga...
  7. pmc Ethnobotanical study of medicinal plants used by people in Zegie Peninsula, Northwestern Ethiopia
    Tilahun Teklehaymanot
    Endod and Other Medicinal Plants Unit, Aklilu Lemma Institute of Pathobiology, Addis Ababa University, PO Box 1176, Addis Ababa, Ethiopia
    J Ethnobiol Ethnomed 3:12. 2007
    ....
  8. ncbi Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta
    G G Kuiper
    Center for Biotechnology and Department of Medical Nutrition, Karolinska Institute, Huddinge, Sweden
    Endocrinology 139:4252-63. 1998
    ....
  9. ncbi An ethnobotanical study on the usage of wild medicinal herbs from Kopaonik Mountain (Central Serbia)
    Snezana Jarić
    Department of Ecology, The Sinisa Stanković Institute for Biological Research, University of Belgrade, Bulevar Despota Stefana 142, Belgrade, Serbia and Montenegro
    J Ethnopharmacol 111:160-75. 2007
    ..rheumatism and skin ailments) and Ficaria verna Huds. (tubers for treating haemorrhoids). In addition, 10 wild species used in veterinary medicine, as well as 25 herbs used for human nourishment were noted...
  10. ncbi Almond consumption and cardiovascular risk factors in adults with prediabetes
    Michelle Wien
    University of Medicine and Dentistry of New Jersey, Newark, New Jersey, USA
    J Am Coll Nutr 29:189-97. 2010
    ....
  11. ncbi Medicinal plants of the Shinasha, Agew-awi and Amhara peoples in northwest Ethiopia
    Mirutse Giday
    Aklilu Lemma Institute of Pathobiology, P O Box 1176, Addis Ababa University, Addis Ababa, Ethiopia
    J Ethnopharmacol 110:516-25. 2007
    ..Measures are needed to conserve plants that are reported as scarce in the study area but still are only harvested from the wild...
  12. ncbi Safety of herbal supplements: a guide for cardiologists
    Pieter A Cohen
    Harvard Medical School, Cambridge Health Alliance, Somerville, MA 02143, USA
    Cardiovasc Ther 28:246-53. 2010
    ..We review clinically relevant patterns of adverse cardiovascular reactions to herbal supplements, and we provide resources and recommendations for practicing cardiologists evaluating patients with suspected herbal adverse effects...
  13. ncbi Korean red ginseng (Panax ginseng) improves insulin sensitivity and attenuates the development of diabetes in Otsuka Long-Evans Tokushima fatty rats
    Hyun Joo Lee
    Department of Internal Medicine, Yonsei University College of Medicine, Seoul 120 752, Korea
    Metabolism 58:1170-7. 2009
    ....
  14. ncbi Folk phytotherapeutical plants from Maratea area (Basilicata, Italy)
    Paolo Maria Guarrera
    Museo Nazionale Arti e Tradizioni Popolari, Piazza Marconi 8 10, 00144 Rome, Italy
    J Ethnopharmacol 99:367-78. 2005
    ..graeca (coughs) and Ceterach officinarum (malaria), while in the ethnoveterinary field, we have Pteridium aquilinum (wolf bites) and Spartium junceum (fractures of animal limbs)...
  15. pmc Plants traditionally prescribed to treat tazo (malaria) in the eastern region of Madagascar
    Milijaona Randrianarivelojosia
    Groupe de Recherche sur le Paludisme, Institut Pasteur de Madagascar BP 1274, Antananarivo 101 Madagascar
    Malar J 2:25. 2003
    ..Thus, it is worth documenting the ethnobotanical data, and testing the antiplasmodial activity of the extractive from plants...
  16. ncbi Estrogen-like activity of ginsenoside Rg1 derived from Panax notoginseng
    Robbie Y K Chan
    The Open Laboratory of Chirotechnology, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, Peoples Republic of China
    J Clin Endocrinol Metab 87:3691-5. 2002
    ..Our results indicate that ginsenosides Rg1 has estrogen-like activity and should be classified as a novel class of potent phytoestrogen...
  17. ncbi Ethnobotanical study on medicinal plants around Mt.Yinggeling, Hainan Island, China
    Xi Long Zheng
    South China Botanical Garden, The Chinese Academy of Sciences, Guangzhou 510650, China
    J Ethnopharmacol 124:197-210. 2009
    ..The main objectives were to collect information on the use of medicinal plants and compare medicinal plant traditions between Run and Qi...
  18. ncbi The in vitro cytotoxic and apoptotic activity of Triphala--an Indian herbal drug
    Swayamjot Kaur
    Department of Botanical Sciences, Guru Nanak Dev University, Amritsar 143005, India
    J Ethnopharmacol 97:15-20. 2005
    ..The suppression of the growth of cancer cells in cytotoxic assays may be due to the gallic acid-a major polyphenol observed in "Triphala"...
  19. pmc Attitude and use of herbal medicines among pregnant women in Nigeria
    Titilayo O Fakeye
    Department of Clinical Pharmacy and Pharmacy Administration, University of Ibadan, Nigeria
    BMC Complement Altern Med 9:53. 2009
    ..The use of herbal medicines among pregnant women in Nigeria has not been widely studied...
  20. ncbi Oral ginseng formulae for stable chronic obstructive pulmonary disease: a systematic review
    Xuedong An
    Discipline of Chinese Medicine, School of Health Sciences, RMIT University, Bundoora, VIC 3083, Australia
    Respir Med 105:165-76. 2011
    ..Ginseng formulae for stable COPD patients show promising evidence of lung functions and Qol improvement. However, the degree of benefit is uncertain due to potential risk of bias of the included studies...
  21. pmc Dietary blueberry attenuates whole-body insulin resistance in high fat-fed mice by reducing adipocyte death and its inflammatory sequelae
    Jason DeFuria
    Obesity and Metabolism Laboratory and 5Antioxidants Research Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr 139:1510-6. 2009
    ..These results suggest that cytoprotective and antiinflammatory actions of dietary BB can provide metabolic benefits to combat obesity-associated pathology...
  22. ncbi Effect of supplemental phytonutrients on impairment of the flow-mediated brachial artery vasoactivity after a single high-fat meal
    Gary D Plotnick
    Cardiology Division, University of Maryland School of Medicine, Medical Center, 22 South Greene Street, Baltimore, MD 21201, USA
    J Am Coll Cardiol 41:1744-9. 2003
    ..Our objective was to determine if long-term daily administration of phytonutrient supplements can prevent the immediate adverse impact of a high-fat meal and increase the production of nitric oxide...
  23. ncbi Phenolic composition, antioxidant capacity and in vitro cancer cell cytotoxicity of nine prickly pear (Opuntia spp.) juices
    R A Chavez-Santoscoy
    Departamento de Biotecnologia e Ingenieria de Alimentos, Tecnológico de Monterrey, Av Eugenio Garza Sada 2501 Sur, Monterrey CP 64849, NL, Mexico
    Plant Foods Hum Nutr 64:146-52. 2009
    ..The research shows intervarietal differences among prickly pears in terms of juice properties and phytochemicals that could prevent oxidative stress and cancer...
  24. ncbi Herbal remedies in the United States: potential adverse interactions with anticancer agents
    Alex Sparreboom
    Clinical Pharmacology Research Core, Medical Oncology Clinical Research Unit, National Cancer Institute, Bethesda, Maryland 20892, USA
    J Clin Oncol 22:2489-503. 2004
    ..With the narrow therapeutic range associated with most anticancer drugs, there is an increasing need for understanding possible adverse drug interactions in medical oncology...
  25. ncbi Diets containing blueberry extract lower blood pressure in spontaneously hypertensive stroke-prone rats
    Kevin S Shaughnessy
    Department of Biology, University of Prince Edward Island, Charlottetown, PEI, Canada C1A 4P3
    Nutr Res 29:130-8. 2009
    ..Thus, a 3% BB diet may be capable of protecting the kidneys from oxidative damage in SHRSP, thereby reducing the magnitude of hypertension...
  26. pmc Ethnobotany in the Cumbres de Monterrey National Park, Nuevo León, México
    Eduardo Estrada
    Facultad de Ciencias Forestales, Universidad Autonoma de Nuevo Leon, km 145 Carretera Nacional Linares Cd, Victoria, AP 41, 67700, Linares, NL, Mexico
    J Ethnobiol Ethnomed 3:8. 2007
    ..Most of the cited uses (98) were found to be medicinal ones...
  27. ncbi Preliminary comparative analysis of medicinal plants used in the traditional medicine of Bulgaria and Italy
    Maria Lucia Leporatti
    Department of Vegetal Biology University La Sapienza, 00185, Roma, Italy
    J Ethnopharmacol 87:123-42. 2003
    ..The remaining 20% have very different uses, several of these being particularly noteworthy. The role played by edible plants, moreover, is important, about 30% being employed as medicine...
  28. ncbi Medicinal plants used by the Bapedi traditional healers to treat diarrhoea in the Limpopo Province, South Africa
    S S Semenya
    Department of Biodiversity, University of Limpopo, Sovenga 0727, South Africa
    J Ethnopharmacol 144:395-401. 2012
    ..Documentation of this nature usually provides the basis for selecting medicinal plants for future phytochemical and pharmaceutical studies aimed at developing new, effective and affordable plant-derived diarrhoea remedies...
  29. pmc Reduction of common cold symptoms by encapsulated juice powder concentrate of fruits and vegetables: a randomised, double-blind, placebo-controlled trial
    Stephanie Roll
    Institute for Social Medicine, Epidemiology and Health Economics, Charité University Medical Centre, Luisenstrasse 57, 10098 Berlin, Germany
    Br J Nutr 105:118-22. 2011
    ..Intake of a dietary supplement from fruits and vegetables was associated with a 20 % reduction of moderate or severe common cold symptom days in healthcare professionals particularly exposed to patient contact...
  30. ncbi Effects of encapsulated fruit and vegetable juice powder concentrates on oxidative status in heavy smokers
    Cristina Novembrino
    Dipartimento di Scienze Mediche, Universita degli Studi di Padova, Padua, Italy
    J Am Coll Nutr 30:49-56. 2011
    ..We evaluated the effects of 2 different encapsulated formulas, consisting primarily of mixed juice powder concentrate, on oxidative status compared with placebo...
  31. ncbi Use of over-the-counter medications and herbal remedies in pregnancy
    Jerrie S Refuerzo
    Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Wayne State University, Detroit, Michigan 48201, USA
    Am J Perinatol 22:321-4. 2005
    ..5% of patients, with up to 13.6% consuming four or more medications. The use of prescribed and OTC, medications, and herbal/alternative therapy, is common in pregnancy, with many patients consuming more than one agent at a time...
  32. ncbi Relevance of in vitro and clinical data for predicting CYP3A4-mediated herb-drug interactions in cancer patients
    Andrew K L Goey
    Utrecht University, Utrecht Institute for Pharmaceutical Sciences, Department of Pharmaceutical Sciences, Division of Pharmacoepidemiology and Clinical Pharmacology, The Netherlands
    Cancer Treat Rev 39:773-83. 2013
    ..At last, midazolam as a model substrate for CYP3A4, has convincingly shown to correctly predict clinical interactions between CAM and anticancer drugs...
  33. ncbi Effects of almond dietary supplementation on coronary heart disease lipid risk factors and serum lipid oxidation parameters in men with mild hyperlipidemia
    Beman Ali Jalali-Khanabadi
    Department of Biochemistry, Faculty of Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
    J Altern Complement Med 16:1279-83. 2010
    ..The aim of this study was to evaluate the effects of dietary supplementation with almond on serum lipid levels and their relation to lipid oxidation parameters in men with mild hyperlipidemia...
  34. ncbi Revisiting the ancient concept of botanical therapeutics
    Barbara M Schmidt
    Rutgers University, School of Environmental and Biological Sciences, Biotech Center, 59 Dudley Road, New Brunswick, New Jersey 08901, USA
    Nat Chem Biol 3:360-6. 2007
    ..Developing innovative scientific methods for discovery, validation, characterization and standardization of these multicomponent botanical therapeutics is essential to their acceptance into mainstream medicine...
  35. pmc Unraveling the relationship between grapes and health
    John M Pezzuto
    College of Pharmacy and 6Department of Chemistry, University of Hawaii, Hilo, HI 96720, USA
    J Nutr 139:1783S-7S. 2009
    ..The ability to correlate heretofore-uncharacterized "signatures" with biologic outcome could fundamentally transform copious amounts of disparate information into a coherent explanation of human disease prevention...
  36. ncbi Safety and toxicological evaluation of a novel anti-obesity formulation LI85008F in animals
    A V Krishnaraju
    Laila Impex R and D Centre, Unit I, Phase III, Jawahar Autonagar, Vijayawada 520007, India
    Toxicol Mech Methods 20:59-68. 2010
    ..The NOAEL of LI85008F was found to be greater than 2500 mg/kg body weight. These results demonstrate the broad spectrum safety of LI85008F in animal models...
  37. ncbi Heavy metal hazards of Nigerian herbal remedies
    E Obi
    Toxicology Unit, Department of Pharmacology, College of Health Sciences, Nnamdi Azikiwe University, Nnewi, Nigeria
    Sci Total Environ 369:35-41. 2006
    ..These data alert us to the possibility of heavy metal toxicity from herbal products in Nigeria. The public health hazards from ingestion of herbal medicines should be identified and disclosed by in-depth risk assessment studies...
  38. ncbi Search for natural products related to regeneration of the neuronal network
    Chihiro Tohda
    Research Center for Ethnomedicines, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Sugitani, Japan
    Neurosignals 14:34-45. 2005
    ..Trigonelline, a constituent of coffee beans, demonstrated the regeneration of dendrites and axons, in addition to memory improvement...
  39. pmc Medicinal plants used in Northern Peru for reproductive problems and female health
    Rainer W Bussmann
    William L, Brown Center, Missouri Botanical Garden, St Louis, MO 63166 0299, USA
    J Ethnobiol Ethnomed 6:30. 2010
    ..The information gained on frequently used traditional remedies might give some leads for future targets for further analysis in order to develop new drugs...
  40. pmc Dietary flaxseed administered post thoracic radiation treatment improves survival and mitigates radiation-induced pneumonopathy in mice
    Melpo Christofidou-Solomidou
    Department of Medicine, Pulmonary Allergy and Critical Care Division, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    BMC Cancer 11:269. 2011
    ..We previously reported that dietary FS prevents pneumonopathy in a rodent model of thoracic X-ray radiation therapy (XRT). However, flaxseed's therapeutic usefulness in mitigating radiation effects post-exposure has never been evaluated...
  41. pmc Use of traditional medicines in the management of HIV/AIDS opportunistic infections in Tanzania: a case in the Bukoba rural district
    Daniel P Kisangau
    Department of Botany, University of Dar es Salaam, Dar es Salaam, Tanzania
    J Ethnobiol Ethnomed 3:29. 2007
    ..Other symptomatic but undefined conditions considered were skin rashes and chronic diarrhea...
  42. ncbi Herbal medicine
    E Ernst
    Department of Complementary Medicine, School of Sport and Health Sciences, University of Exeter, Exeter, United Kingdom
    Med Clin North Am 86:149-61. 2002
    ..The research required to fill the gaps in present knowledge should have a high priority...
  43. pmc An ethnobotanical survey of plants used to manage HIV/AIDS opportunistic infections in Katima Mulilo, Caprivi region, Namibia
    Kazhila C Chinsembu
    University of Namibia, Faculty of Science, Department of Biological Sciences, P B 13301, Windhoek, Namibia
    J Ethnobiol Ethnomed 6:25. 2010
    ..Further research is needed to isolate the plants' active chemical compounds and understand their modes of action...
  44. pmc Alpine ethnobotany in Italy: traditional knowledge of gastronomic and medicinal plants among the Occitans of the upper Varaita valley, Piedmont
    Andrea Pieroni
    University of Gastronomic Sciences, Via Amedeo di Savoia 8, I 12060 Pollenzo Bra, Italy
    J Ethnobiol Ethnomed 5:32. 2009
    ..glacialis, and A. umbelliformis) should be seriously reconsidered in terms of sustainability, given the limited availability of these species, even though their collection is culturally salient in the entire study area...
  45. ncbi The effect of HESA-A on psoriasis vulgaris
    Amrollah Ahmadi
    Cancer Institute Research Center, Tehran University of Medical Sciences, Tehran, Iran
    J Drugs Dermatol 7:559-61. 2008
    ..Psoriasis vulgaris is one of the most common chronic skin disorders without any curative treatment. The aim of this study was to investigate the efficacy and safety of HESA-A in the treatment of psoriasis...
  46. ncbi Chocolate and medicine: dangerous liaisons?
    Donatella Lippi
    Department of Anatomy, Histology and Legal Medicine, University of Florence, Italy
    Nutrition 25:1100-3. 2009
    ..Chocolate is no longer deemed a guilty pleasure, and it may have positive health benefits when eaten in moderation as part of a balanced diet...
  47. ncbi Diet supplementation with acai (Euterpe oleracea Mart.) pulp improves biomarkers of oxidative stress and the serum lipid profile in rats
    Melina Oliveira de Souza
    Núcleo de Pesquisas em Ciências Biológicas, Universidade Federal de Ouro Preto, Ouro Preto, Minas Gerais, Brazil
    Nutrition 26:804-10. 2010
    ..We investigated the antioxidant potential and hypocholesterolemic effects of acai (Euterpe oleracea Mart.) pulp ingestion in rats fed a standard or hypercholesterolemic diet...
  48. ncbi Argemone mexicana decoction versus artesunate-amodiaquine for the management of malaria in Mali: policy and public-health implications
    Bertrand Graz
    Antenna Technologies, Geneva, Switzerland
    Trans R Soc Trop Med Hyg 104:33-41. 2010
    ..In view of the low rate of severe malaria and good tolerability, AM may also constitute a first-aid treatment when access to other antimalarials is delayed...
  49. ncbi Estrogen receptor alpha mediates the proliferative but not the cytotoxic dose-dependent effects of two major phytoestrogens on human breast cancer cells
    M Maggiolini
    Department of Pharmaco-Biology, University of Calabria, Rende-Cosenza, Italy
    Mol Pharmacol 60:595-602. 2001
    ..Thus, the mode of action of phytoestrogens and the balance between being risk or chemopreventive factors for breast cancer may depend on the dietary load...
  50. ncbi Assessment of herbal medicinal products: challenges, and opportunities to increase the knowledge base for safety assessment
    Scott A Jordan
    Marketed Biologicals, Biotechnology and Natural Health Products Bureau, Marketed Health Products Directorate, Health Canada, 200 Tunney s Pasture Driveway, Postal Locator 0701 A, Ottawa, Ontario, Canada
    Toxicol Appl Pharmacol 243:198-216. 2010
    ..The example of Aristolochia and aristolochic acids is used to highlight the challenges related to safety assessment, and the opportunities that exist to more accurately elucidate the toxicity of herbal medicines...
  51. pmc Preparation and use of plant medicines for farmers' health in Southwest Nigeria: socio-cultural, magico-religious and economic aspects
    Taiwo E Mafimisebi
    Department of Agricultural Economics and Extension, School of Agriculture and Agricultural Technology, The Federal University of Technology, Akure, Nigeria
    J Ethnobiol Ethnomed 6:1. 2010
    ....
  52. ncbi Serious psychiatric and neurological adverse effects of herbal medicines -- a systematic review
    E Ernst
    Complementary Medicine, Peninsula Medical School, Universities of Exeter and Plymouth, Exeter, UK
    Acta Psychiatr Scand 108:83-91. 2003
    ..The aim of this systematic review was to provide a summary of recent data on severe psychiatric and neurological adverse effects of herbal remedies...
  53. ncbi Passiflora: a review update
    Kamaldeep Dhawan
    Department of Drugs Control Administration, Government of Haryana State, Sector 6, Panchkula 134109, India
    J Ethnopharmacol 94:1-23. 2004
    ....
  54. ncbi Phytoestrogen supplements for the treatment of hot flashes: the Isoflavone Clover Extract (ICE) Study: a randomized controlled trial
    Jeffrey A Tice
    Division of General Internal Medicine, Department of Medicine, University of California, San Francisco 94143, USA
    JAMA 290:207-14. 2003
    ..Dietary supplements containing isoflavones are widely used as alternatives to hormonal therapies for hot flashes, but there is a paucity of data supporting their efficacy...
  55. ncbi Hawthorn: potential roles in cardiovascular disease
    Wei Tien Chang
    Emergency Resuscitation Center, Department of Medicine Section of Emergency Medicine, University of Chicago, IL 60637, USA
    Am J Chin Med 33:1-10. 2005
    ..Further clinical trials as well as pharmacokinetic and mechanistic studies are needed to explore and confirm its effectiveness, safety and pharmacological mechanism...
  56. ncbi An ethnobotanical study of medicinal and aromatic plants in the Natural Park of "Serra de São Mamede" (Portugal)
    Joana Camejo-Rodrigues
    J Ethnopharmacol 89:199-209. 2003
    ..This is the first study of medicinal and aromatic plants in Portugal to use ethnobotanical methodology...
  57. ncbi Benefit of an extract of Tripterygium Wilfordii Hook F in patients with rheumatoid arthritis: a double-blind, placebo-controlled study
    Xuelian Tao
    Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland 20892, USA
    Arthritis Rheum 46:1735-43. 2002
    ..To examine the safety and efficacy of an extract of Tripterygium wilfordii Hook F (TWHF) in the treatment of patients with rheumatoid arthritis (RA)...
  58. ncbi Ayurvedic medicine. Core concept, therapeutic principles, and current relevance
    Arvind Chopra
    Center for Rheumatic Diseases Hermes Doctor House, Bharati Hospital and Medical College, Inlaks Budhrani Hospital, Pune, India
    Med Clin North Am 86:75-89, vii. 2002
    ..To understand Ayurvedic medicine, it would be necessary to first understand the origin, basic concept and principles of Ayurveda...
  59. ncbi Cardiovascular adverse effects of herbal medicines: a systematic review of the recent literature
    E Ernst
    Complementary Medicine, Peninsula Medical School, University of Exeter, Devon, United Kingdom
    Can J Cardiol 19:818-27. 2003
    ..In conclusion, herbal medicinal products are regularly associated with serious cardiovascular adverse events but the size of this problem cannot be estimated at present. Vigilance and research seem to be the best way forward...
  60. pmc Spontaneous bleeding associated with ginkgo biloba: a case report and systematic review of the literature: a case report and systematic review of the literature
    Stephen Bent
    Osher Center for Integrative Medicine, University of California, San Francisco, USA
    J Gen Intern Med 20:657-61. 2005
    ..Ginkgo biloba (ginkgo) is a herbal remedy used by over 2% of the adult population in the United States. Several review articles have suggested that ginkgo may increase the risk of bleeding...
  61. pmc An ethnobotanical survey of medicinal plants in Babungo, Northwest Region, Cameroon
    David J Simbo
    Department of Bioscience Engineering, Faculty of Science, University of Antwerp, Groenenborgerlaan 171, 2020 Antwerp, Belgium
    J Ethnobiol Ethnomed 6:8. 2010
    ..An ethnobotanical survey was undertaken to record information on medicinal plants from traditional medical practitioners in Babungo and to identify the medicinal plants used for treating diseases...
  62. ncbi Contribution to the knowledge of the folk plant medicine in Calabria region (Southern Italy)
    N G Passalacqua
    Museo di Storia Naturale della Calabria ed Orto Botanico, Universita della Calabria, 87030 Arcavacata di Rende, Italy
    Fitoterapia 78:52-68. 2007
    ....
  63. ncbi Rose hip herbal remedy in patients with rheumatoid arthritis - a randomised controlled trial
    S N Willich
    Institute for Social Medicine, Epidemiology and Health Economics, Charité University Medical Centre, Berlin, Germany
    Phytomedicine 17:87-93. 2010
    ..To investigate if standardised powder made from rose-hip (Rosa canina) can reduce the symptom score in patients with rheumatoid arthritis...
  64. ncbi Preoperative use of herbal medicines and vitamin supplements
    R P Grauer
    Department of Anaesthesia, St Vincent s Hospital, Melbourne, Victoria
    Anaesth Intensive Care 32:173-7. 2004
    ..Clinicians should endeavour to familiarize themselves with the more popular and significant herbal medications and, as part of the routine preoperative assessment, ask all their patients about their consumption of herbal remedies...
  65. ncbi Ethnomedicinal study of plants used by Sheko ethnic group of Ethiopia
    Mirutse Giday
    Aklilu Lemma Institute of Pathobiology, P O Box 1176, Addis Ababa University, Addis Ababa, Ethiopia
    J Ethnopharmacol 132:75-85. 2010
    ..This study was conducted to document and evaluate knowledge on medicinal plant use by Sheko ethnic group in Southwest Ethiopia...
  66. ncbi Effect of Aloe vera preparations on the human bioavailability of vitamins C and E
    J A Vinson
    Department of Chemistry, University of Scranton, Scranton, PA, 18510 4626, USA
    Phytomedicine 12:760-5. 2005
    ..The absorption is slower and the vitamins last longer in the plasma with the Aloes. Aloe is the only known supplement to increase the absorption of both of these vitamins and should be considered as a complement to them...
  67. ncbi Medicinal plants used by the Criollos of Northwestern Argentine Chaco
    Gustavo F Scarpa
    Instituto de Botánica Darwinion, Casilla de correo 22, B1642HYD, San Isidro, Provincia de Buenos Aires, Buenos Aires, Argentina
    J Ethnopharmacol 91:115-35. 2004
    ..5% of total uses); skin affections (14.6%); respiratory disorders (9.1%); reproductive disorders (8.4%) and affections of the circulatory system (7.7%); and as antipyretics (7.5% of total uses)...
  68. ncbi Lower doses of vanadate in combination with trigonella restore altered carbohydrate metabolism and antioxidant status in alloxan-diabetic rats
    Sameer Mohammad
    School of Life Sciences, Jawaharlal Nehru University, New Delhi 110 067, India
    Clin Chim Acta 342:105-14. 2004
    ..We used low doses of vanadate in combination with Trigonella foenum graecum seed powder (TSP) and evaluated their effect on the enzyme changes in diabetic rats...
  69. ncbi Beneficial role of dietary phytoestrogens in obesity and diabetes
    Sam J Bhathena
    Phytonutrients Laboratory, Beltsville Human Nutrition Research Center, Agricultural Research Service, US Department of Agriculture, Beltsville, MD 20705, USA
    Am J Clin Nutr 76:1191-201. 2002
    ..Further investigations are needed to evaluate the long-term effects of phytoestrogens on obesity and diabetes mellitus and their associated possible complications...
  70. ncbi Short-term blueberry-enriched diet prevents and reverses object recognition memory loss in aging rats
    David H Malin
    University of Houston Clear Lake, Houston, Texas, USA
    Nutrition 27:338-42. 2011
    ..Experiment 2 determined whether a 1-mo BB diet could subsequently reverse existing object memory impairment in aging rats...
  71. ncbi A review of the clinical and toxicological aspects of 'traditional' (herbal) medicines adulterated with heavy metals
    Emma Lynch
    Sandwell and West Birmingham NHS Trust, Regional Laboratory for Toxicology, City Hospital, Birmingham, B18 7QH, UK
    Expert Opin Drug Saf 4:769-78. 2005
    ....
  72. ncbi Preoperative use of herbal medicines: a patient survey
    C M Skinner
    Royal Berkshire Hospital, Reading, UK
    Br J Anaesth 89:792-5. 2002
    ..In addition, herbal remedies can interact with many drugs given in the perioperative period. In this article we summarize the potential perioperative complications that can occur...
  73. ncbi The influence of St. John's wort on the pharmacokinetics and protein binding of imatinib mesylate
    Patrick Smith
    School of Pharmacy and Pharmaceutical Sciences, University of Buffalo, Buffalo, New York, USA
    Pharmacotherapy 24:1508-14. 2004
    ..To determine the effect of St. John's wort on the pharmacokinetics of imatinib mesylate...
  74. pmc Ethnomedicinal study of plants used in villages around Kimboza forest reserve in Morogoro, Tanzania
    Ezekiel Amri
    Department of Science and Laboratory Technology, Dar es Salaam Institute of Technology, Dar es Salaam, Tanzania
    J Ethnobiol Ethnomed 8:1. 2012
    ..An ethnomedicinal study was conducted to document medicinal plants used in the treatment of ailments in villages surrounding Kimboza forest reserve, a low land catchment forest with high number of endemic plant species...
  75. ncbi A multidisciplinary approach to the toxicologic problems associated with the use of herbal medicines
    Thomas Y K Chan
    Drug and Poisons Information Bureau, Division of Clinical Pharmacology, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, China
    Ther Drug Monit 27:53-7. 2005
    ..Toxicological problems associated with the use of herbal medicines are complex and may be easily overlooked. A multidisciplinary team of experts should be made available to provide advice to frontline healthcare professionals...
  76. ncbi Herbal supplements in pregnancy: unexpected results from a multicentre study
    F Facchinetti
    Unit of Obstetrics, Mother Infant Department, University of Modena and Reggio Emilia, Modena, Italy
    Hum Reprod 27:3161-7. 2012
    ..How common is the use of herbal supplements during pregnancy and does it adversely affect the pregnancy outcome?..
  77. ncbi Assessing subjective and psychomotor effects of the herbal medication valerian in healthy volunteers
    Sandra Gutierrez
    Department of Anesthesia and Critical Care, The University of Chicago, MC4028, 5841 South Maryland Avenue, Chicago, IL 60637, USA
    Pharmacol Biochem Behav 78:57-64. 2004
    ..The data suggest that acute administration of valerian does not have mood-altering or psychomotor/cognitive effects in young healthy volunteers...
  78. ncbi The potential adverse effects of habitual use of Catha edulis (khat)
    Molham Al-Habori
    Department of Clinical Biochemistry, Faculty of Medicine and Health Sciences, University of Sana a, P O Box 19065, Sana a, Republic of Yemen
    Expert Opin Drug Saf 4:1145-54. 2005
    ....
  79. ncbi Wormwood (Artemisia absinthium) suppresses tumour necrosis factor alpha and accelerates healing in patients with Crohn's disease - A controlled clinical trial
    Simone Krebs
    Department of Nuclear Medicine, Faculty of Medicine, University of Freiburg, Germany
    Phytomedicine 17:305-9. 2010
    ..These findings provide a base to test wormwood in clinical conditions thought to be mediated by increased production of pro-inflammatory cytokines such as TNF-alpha...
  80. ncbi Demographic and health-related correlates of herbal and specialty supplement use
    Susan Gunther
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    J Am Diet Assoc 104:27-34. 2004
    ....
  81. ncbi An ethnobotanical study of medicinal plants used by the Zay people in Ethiopia
    Mirutse Giday
    Institute of Pathobiology, Addis Ababa University, P O Box 12577, Ethiopia
    J Ethnopharmacol 85:43-52. 2003
    ..Measures for conservation of medicinal plants of the Zay people are urgently needed...
  82. ncbi Botanical medicines for the urinary tract
    Eric Yarnell
    World J Urol 20:285-93. 2002
    ....
  83. ncbi Medication use in a rural gynecologic population: prescription, over-the-counter, and herbal medicines
    Douglas D Glover
    Department of Obstetrics and Gynecology, School of Medicine, Consortium on Reproductive and Developmental Health, Robert C Byrd Health Sciences Center of West Virginia University, Morgantown, WV, USA
    Am J Obstet Gynecol 190:351-7. 2004
    ..The purpose of this study was to document current medication use by a rural female population...
  84. ncbi Treating pregnancy-related nausea and vomiting with ginger
    Sarah A Boone
    Raabe College of Pharmacy, Ohio Northern University, Ada, OH 45810 1078, USA
    Ann Pharmacother 39:1710-3. 2005
    ..To review literature assessing the safety and efficacy of the use of ginger to treat nausea and vomiting in pregnancy...
  85. pmc Effects of Maharishi Amrit Kalash 5 as an Ayurvedic herbal food supplement on immune functions in aged mice
    Ryoichi Inaba
    Department of Occupational Health, Graduate School of Medicine, Gifu University, Gifu, Japan
    BMC Complement Altern Med 5:8. 2005
    ..In this study, we determined the effects of administration of MAK5, one of the Ayurvedic food supplements on immune functions in young and old mice...
  86. ncbi [Preclinical studies of cucurbita maxima (pumpkin seeds) a traditional intestinal antiparasitic in rural urban areas]
    Daysi Díaz Obregón
    Hospital Nacional Edgardo Rebagliati Martins HNERM, Lima
    Rev Gastroenterol Peru 24:323-7. 2004
    ..These findings are accentuated when experimenting with Cucurbita Maxima in a concentration of 30 and 32 gr. Superficial non-erosive gastritis was found in weys rats after 4 hours of administering 9 gr/kg...
  87. pmc Analyzing factors that influence the folk use and phytonomy of 18 medicinal plants in Navarra
    Silvia Akerreta
    Departamento de Biología Vegetal Sección Botánica, Universidad de Navarra, C Irunlarrea s n, Pamplona, 31080, Navarra, Spain
    J Ethnobiol Ethnomed 3:16. 2007
    ..high blood pressure (Rhamnus alaternus, Olea europaea...) or skin diseases (Hylotelephium maximum, H. telephium, Anagallis arvensis, A. foemina)...
  88. pmc Ethnophytotherapeutical research in the high Molise region (Central-Southern Italy)
    Paolo Maria Guarrera
    Museo Nazionale Arti e Tradizioni Popolari, Piazza Marconi 8 10, 00144 Rome, Italy
    J Ethnobiol Ethnomed 4:7. 2008
    ..Primordial traditions (e.g. harvest feasts) are typical of the region...
  89. ncbi Does the hip powder of Rosa canina (rosehip) reduce pain in osteoarthritis patients?--a meta-analysis of randomized controlled trials
    R Christensen
    The Parker Institute, Musculoskeletal Statistics Unit, Frederiksberg Hospital, Denmark
    Osteoarthritis Cartilage 16:965-72. 2008
    ..Meta-analysis of randomized controlled trials (RCTs)--of a hip powder of Rosa canina (rosehip) preparation for symptomatic treatment of osteoarthritis (OA), in order to estimate the empirical efficacy as a pain reducing compound...
  90. ncbi Role of apoptosis in HESA--a teratogenicity in mouse fetus
    Seyed A Moallem
    Pharmacy Faculty, Mashhad University of Medical Sciences, Mashhad, Iran
    Drug Chem Toxicol 32:186-90. 2009
    ..HESA-A changed the cell-death pattern; in moderate doses of the drug, the apoptosis-to-necrosis ratio was more than 1, and in higher doses, this ratio was less than 1...
  91. ncbi Studies on correlation of antimutagenic and antiproliferative activities of Juglans regia L
    Kamaljit Kaur
    Department of Botanical Sciences, Guru Nanak Dev University, Amritsar, India
    J Environ Pathol Toxicol Oncol 22:59-67. 2003
    ..Further studies are still needed to evaluate the cytotoxicity in experiments carried out in vivo...
  92. ncbi Self-reported competence of Estonian community pharmacists in relation to herbal products: findings from a health-system in transition
    Daisy Volmer
    Department of Pharmacy, University of Tartu, Tartu, Estonia
    Phytother Res 25:381-6. 2011
    ..Health system reforms in Estonia may need to be accompanied by enhanced training for pharmacists to provide advice about the safe and appropriate use of herbal products...
  93. pmc Evaluation and implications of natural product use in preoperative patients: a retrospective review
    Allison R King
    University of Kansas Drug Information Center, 3901 Rainbow Boulevard, MS 4040, Kansas City, Kansas 66160, USA
    BMC Complement Altern Med 9:38. 2009
    ....
  94. ncbi Screening of the topical anti-inflammatory activity of some Central American plants
    S Sosa
    DEMREP, University of Trieste, Via A Valerio 6, 34127, Trieste, Italy
    J Ethnopharmacol 81:211-5. 2002
    ..Therefore, the tested plants are promising sources of principles with high anti-inflammatory activity...
  95. ncbi Plants used to treat malaria in Nyakayojo sub-county, western Uganda
    Torunn Stangeland
    Department of Ecology and Natural Resource Management, Norwegian University of Life Sciences, P O Box 5003, NO 1432 Aas, Norway
    J Ethnopharmacol 137:154-66. 2011
    ..Two of the most vulnerable groups affected by malaria are young children and pregnant women and plants are commonly used in their treatment...
  96. ncbi Ethnoknowledge of Bukusu community on livestock tick prevention and control in Bungoma district, western Kenya
    Wycliffe Wanzala
    School of Pure and Applied Sciences, Department of Biological Sciences, South Eastern University College A Constituent College of the University of Nairobi, P O Box 170 90200, Kitui, Kenya
    J Ethnopharmacol 140:298-324. 2012
    ..Their collective and accumulative ethnoveterinary knowledge is likely to be just as rich and worth documenting...
  97. ncbi Effect of Mimosa pudica root powder on oestrous cycle and ovulation in cycling female albino rat, Rattus norvegicus
    S Valsala
    Department of Zoology, Annamalai University, Annamalainagar 608002, Tamilnadu, India
    Phytother Res 16:190-2. 2002
    ..There was a significant reduction in the number of normal ova in rats treated with the root powder compared with the control rats, and a significant increase in the number of degenerated ova...
  98. ncbi Korean mistletoe lectin-induced apoptosis in hepatocarcinoma cells is associated with inhibition of telomerase via mitochondrial controlled pathway independent of p53
    Su Yun Lyu
    College of Natural Sciences, Seoul Women s University, Seoul, Korea
    Arch Pharm Res 25:93-101. 2002
    ..Taken together, our results suggest that the VCA, considered as a telomerase-inhibitor, can be envisaged as a candidate for enhancing sensitivity of conventional anticancer drugs...
  99. ncbi Young coconut juice, a potential therapeutic agent that could significantly reduce some pathologies associated with Alzheimer's disease: novel findings
    Nisaudah Radenahmad
    Department of Anatomy, Faculty of Science, Prince of Songkla University, Hat Yai, Thailand
    Br J Nutr 105:738-46. 2011
    ..This is a novel study demonstrating that YCJ could have positive future implications in the prevention and treatment of AD in menopausal women...
  100. ncbi Multiple organ toxicity of a Nigerian herbal supplement (U & D Sweet bitter) in male albino rats
    Ezejiofor Na
    Abia State University, College of Health Sciences, Uturu, Abia State, Nigeria
    Pak J Pharm Sci 21:426-9. 2008
    ..This study suggests that U & Dee Sweet Bitter may have toxic effect on the spleen, pancreas, and heart of male albino rat...
  101. ncbi Anticancer effects of HESA-A in patients with metastatic colon cancer
    Amrollah Ahmadi
    Institute of Cancer Research, Medical Sciences University of Tehran, Tehran, Iran
    Integr Cancer Ther 8:71-4. 2009
    ..HESA-A is a natural biological compound of herbal-marine origin. The aim of this study was to investigate the therapeutic effects of HESA-A in patients with metastatic colon cancer...

Research Grants70

  1. TOXICOLOGY OF ENVIRONMENT CONTAMINANTS
    Stephen Safe; Fiscal Year: 2007
    ..The proposed training program will continue to provide trainees with a challenging academic and research environment that will prepare them for future careers in academic, industry and government. ..
  2. Effect of Rhamnetin on Oxidative Stress and Prostate Cancer
    Sanjeev Shukla; Fiscal Year: 2013
    ..Since prostate cancer is a disease of aging male population and second largest killer after lung cancer in the United States, prevention strategies are urgently needed. ..
  3. Exploratory Planning for a Proposed GEOHealth Hub in the Alto Mayo Region: - USA
    Paula E North; Fiscal Year: 2013
    ..focus on indoor/outdoor air quality, water/soil quality, and quality and safety of traditional medicinal plant preparations. Although health concerns of the broad populace will be addressed, the critical problems of infant/maternal ..
  4. Herb-Opioid Interactions
    Danny Shen; Fiscal Year: 2003
    ..Overall, the proposed research will provide a definitive assessment of the potential and clinical significance of adverse interactions between SJW and opioids in the context of cancer pain therapy. ..
  5. 5-Lipoxygenase inhibition as an adjuvant glioma therapy
    Glen Stevens; Fiscal Year: 2005
    ..It would allow patients to "take charge" of their lives, which is itself a life enhancing experience and a major reason whv patients with GBM frequentlv use CAM therapies. ..
  6. Ginkgo biloba for ECT-induced Memory Deficits
    JOHN MARKOWITZ; Fiscal Year: 2003
    ..will utilize larger groups and additional cognitive tests will be incorporated to provide more definitive conclusions regarding efficacy, optimal dose and duration, persistence of effects, and safety and tolerability ..
  7. Novel Herbal Medicine for the Treatment of Prostate Cancer
    CHENDIL DAMODARAN; Fiscal Year: 2009
    ..Additionally, the results from the proposed studies can be exploited to develop chemotherapeutic and/or chemoprevention strategies for PCa, thus leading to clinical trials to determine the efficacy of the cRL-CI against PCa. ..
  8. MENTORED MEDICAL STUDENT CLINCAL RESEARCH PROGRM
    Harriet Hopf; Fiscal Year: 2000
    ..It is expected that this will consolidate information and skills acquired in previous training and will be the first step in a career in patient-based investigation. ..
  9. Functional Bowel Disorders in Chinese Medicine
    Brian Berman; Fiscal Year: 2004
    ..abstract_text> ..
  10. Androgenic And Antiandorgenic Interactions Of PC-SPES
    CHARLES ROSELLI; Fiscal Year: 2002
    ..Specific Aim 3: To evaluate the effect of PCSPES on Cytochrome P450-mediated metabolism of androgenic and antiandrogenic drugs by the liver, in order to identify possible interactions of PC-SPES with other hormone therapies. ..
  11. EFFICACY OF HERBAL EXTRACT TO TREAT GI BLEEDING
    SUDERSHAN SANDUJA; Fiscal Year: 2001
    ..PROPOSED COMMERCIAL APPLICATION: The market for an effective and safe therapeutic agent to treat several types of hemorrhagic disorder notably bleeding from esophageal varices, gastric and duodenal ulcers will be enormous. ..
  12. Clinical Assessment of Herb-Drug Interactions
    Bill Gurley; Fiscal Year: 2005
    ..e. CYPIA2, CYP2D6 and CYP3A4); and (3) whether prolonged herb use can modulate P-gp-mediated drug absorption and elimination. ..
  13. Plant Foods and Endometrial Cancer Epidemiology
    PAMELA HORN ROSS; Fiscal Year: 2005
    ..A priori definitions and factor analysis will be used to identify dietary patterns. The results of the proposed analyses will provide further understanding of the etiology of endometrial cancer. ..
  14. PHARMACOLOGY OF COMBINED EPHEDRINE/CAFFEINE SUPPLEMENTS
    Christine Haller; Fiscal Year: 2004
    ..The long-term objective for the proposed studies is to develop Dr. Haller into an independent career clinical researcher in this field of study. ..
  15. Multidiscipli. GCRC-Mentorship Program in Womens Health
    Lorraine Fitzpatrick; Fiscal Year: 2003
    ..abstract_text> ..
  16. DNA Damage: Fruit & Vegetable Effects in a Feeding Trial
    Johanna Lampe; Fiscal Year: 2005
    ..The existing intervention provides an ideal design in which to evaluate the relationships between biotransformation enzyme systems and DNA damage in humans. ..
  17. UGT Polymorphisms and Hormonally-Mediated Biomarkers in Premenopausal Women
    Johanna Lampe; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  18. ALTERNATIVE THERAPIES FOR MENOPAUSE: A RANDOMIZED TRIAL
    Katherine Newton; Fiscal Year: 2004
    ....
  19. Hormone Status Postmenopause: Colonic Bacterial Effects
    Johanna Lampe; Fiscal Year: 2003
    ..The results of this study will provide novel data regarding the relationship of the equol-producer phenotype, a marker of colonic nticrofloral environment, to lifetime estrogen exposure. ..
  20. HRT Decision Making in the Post-WHI Era
    Katherine Newton; Fiscal Year: 2006
    ..This study will provide key information about HRT decision making, and experiences with HRT discontinuation, in an era of increased scientific clarity about HRT's risks and benefits. [unreadable] [unreadable]..
  21. GLUTATHIONE TRANSFERASES IN HUMANS: DIETARY INFLUENCES
    Johanna Lampe; Fiscal Year: 2006
    ..abstract_text> ..
  22. Ginger Control of Chemotherapy Induced Nausea and Emesis
    Suzanna Zick; Fiscal Year: 2004
    ..Participants will be followed for 48 hours after infusion in order to assess frequency and severity of nausea and vomiting. Baseline and 48 hour post chemotherapy labs will be used to assess safety profile of ginger. ..
  23. Breast Cancer, Benign Breast Disease, and Isoflavone Metabolism in Chinese Women
    Johanna Lampe; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  24. Glucuronidation in Humans--Genotypes and Phenotypes
    Johanna Lampe; Fiscal Year: 2004
    ..The randomized cross-over design will allow us to test efficiently for diet effects within individuals, as well as for gene-by-diet and sex-by-diet interactions. ..
  25. Serum IGFs--Effects of a Soy Intervention in Humans
    Johanna Lampe; Fiscal Year: 2002
    ..It provides an ideal design to evaluate the effects of isoflavones on the IGF system and to explore relationships between IGFs and colonic epithelial cell proliferation in humans. ..
  26. Evolution of Estrogen Receptor-Ligand Interactions
    Jennifer Fox; Fiscal Year: 2006
    ..Such an experimental system will allow the rigorous testing of hypotheses about ER-ligand structure function relationships and the dynamics of receptor-ligand coevolution. ..
  27. Human Gut Microflora Profiling for Population Studies
    Johanna Lampe; Fiscal Year: 2006
    ..abstract_text> ..
  28. Breast and Bone Density: Impact of Colonic Environment
    Johanna Lampe; Fiscal Year: 2006
    ..If equol-producer phenotype can predict differences in cumulative estrogen exposure / metabolism, it may serve as an early marker of breast cancer risk. ..
  29. HOST GENES AND COLONIC BACTERIA--PROBING FOR INHERITANCE
    Johanna Lampe; Fiscal Year: 2002
    ..If we can establish that the equol-producer phenotype is an inherited trait, we can then work to identify the associated genotype and determine more effectively whether this is a biomarker of breast cancer risk. ..
  30. Inhibition of Pancreatic Cancer by New PPARgamma Agonis*
    Stephen Safe; Fiscal Year: 2008
    ..PPAR? -active C-substituted DIMs that inhibit pancreatic cancer cell growth in vitro and in vivo, and these will serve as lead compounds for development of new drugs for clinical treatment of this devastating disease ..
  31. Nutrition and Thyroid Cancer Risk in the CTS Cohort
    PAMELA HORN ROSS; Fiscal Year: 2007
    ..The results of this research will have important implications for improving our understanding of the etiology of this disease which disproportionately affects young women. [unreadable] [unreadable] [unreadable]..
  32. Missed Opportunities for Diagnosis of Child Maltreatment
    ELISABETH GUENTHER SKOKAN; Fiscal Year: 2007
    ..abstract_text> ..
  33. Effect of Chinese herbal medicine on food allergy
    Xiu Min Li; Fiscal Year: 2010
    ....
  34. Ascorbylation of Oxidized Lipids and Atherosclerosis
    Jan Frederik Stevens; Fiscal Year: 2010
    ..This project contributes to our long- term goal to determine the role of lipid peroxidation in inflammatory and age-related disease and how its effects can be modulated by therapeutic or dietary intervention. ..
  35. EFFECTS OF SAM IN PATIENTS WITH ALCOHOLIC LIVER DISEASE
    Charles Halsted; Fiscal Year: 2007
    ..By confirming the relationship of abnormal methionine metabolism to clinical, biochemical, and pathologic disease severity, the study will establish a metabolic basis for determining the efficacy of SAM intervention in ALD. ..
  36. Use of Curcumin and Flaxsseed in Radiation Pneumonopathy
    Melpo Christofidou Solomidou; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  37. MECHANISMS OF CADMIUM TOXICITY IN EPITHELIAL CELLS
    WALTER PROZIALECK; Fiscal Year: 2007
    ..Furthermore, the results of these studies could have more general implications regarding the mechanisms by which toxic substances affect living organisms. ..
  38. DIETARY OBESITY
    George Bray; Fiscal Year: 2007
    ..We now propose these well founded, important and exciting studies which will provide critical new insights into anatomical, physiological and molecular mechanisms by which high levels of dietary fat induce obesity. ..
  39. ALA & EPA/DHA (w-3) Effects On Inflammatory Markers in Insulin Resistant Adults
    Christopher Gardner; Fiscal Year: 2007
    ..The adults with the metabolic syndrome selected for this study are those that are at increased risk of heart disease, and those most likely to be benefit from the different therapies tested. [unreadable] [unreadable] [unreadable]..
  40. Prediction of Drug-Drug Interactions
    Zeruesenay Desta; Fiscal Year: 2007
    ..The in vitro parameter estimates will be incorporated into our physiological pharmacokinetic models to test the predictive power and build a universal platform for complex interactions between chemicals. ..
  41. Botanicals for Chlamydia pneumonia infections-Revision 1
    Gail Mahady; Fiscal Year: 2005
    ..Data and active standardized extracts developed during this work will be used as the basis for future clinical trials. ..
  42. EICOSANOIDS AND NO IN CEREBROVASCULAR THROMBOSIS
    Kenneth Wu; Fiscal Year: 2003
    ..It is intended that this program will enable several laboratories to work individually and together to achieve the highest degree of innovating and productivity. ..
  43. BIODEFENSE THERAPEUTICS FROM UNCULTURED MICROORGANISMS
    Kim Lewis; Fiscal Year: 2005
    ..Determination of chemical structure will be performed by a combination of MS and NMR methods. ..
  44. Creatine: Is It a Body Builder for Cancer Patients?
    Aminah Jatoi; Fiscal Year: 2004
    ..obtain longitudinal toxicity and quality of life data on this same cohort of 50 patients and will make direct comparisons between treatment arms on toxicity incidence and severity and on maximal quality of life scores ..
  45. Conference on Molecular Biology of the Heart
    Leslie Leinwand; Fiscal Year: 2002
    ..It will be a multidisciplinary meeting that should bring together people who are beginning to have regular dialogues but whose traditions have been somewhat separate. ..
  46. Conference on Emerging Research Technologies
    Gail Mahady; Fiscal Year: 2004
    ....
  47. A sensitive triple quadrupole mass spectrometer
    Stephen Barnes; Fiscal Year: 2004
    ..It is anticipated that a commercial nanospray interface for use in nanoLC-MS analysis will be available by the fall of 2003. ..
  48. Benefits & Risks of Popular Weight Loss Diets
    Christopher Gardner; Fiscal Year: 2003
    ..The data generated from this preliminary/feasibility study will be used to strengthen the proposal and design of a future full-scale study. ..
  49. ESTROGEN INDUCED RESPONSES VIA ER/SPL COMPLEXES
    Stephen Safe; Fiscal Year: 2002
    ..These results will ultimately facilitate design of chemotherapeutic approaches which target specific genes. ..
  50. PEDIATRIC ONCOLOGY GROUP STUDIES
    Thomas McLean; Fiscal Year: 2002
    ....
  51. Liquid Chromatography Mass Spectrometry system
    Adrian Franke; Fiscal Year: 2005
    ..abstract_text> ..
  52. Pressure-Based Pharmacological Alcoholism Treatments
    DARYL DAVIES; Fiscal Year: 2005
    ..These agents can form the bases of novel prevention and treatment strategies for alcoholism and alcohol abuse. ..
  53. Hybrid triple quadrupole linear ion trap mass spectrometer
    Jan Stevens; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  54. The Role of Statin Lactones in Statin Toxicity
    Uwe Christians; Fiscal Year: 2006
    ..Our secondary goal will be to compare the lactones/acids of the different statins with each other. ..
  55. MATRIX-ASSISTED LASER DESORPTION TOF MASS SPECTROMETER
    Richard van Breemen; Fiscal Year: 2001
    ..abstract_text> ..
  56. 2,3,7,8,--TCDD Effects on the Estrogenic Responses
    Stephen Safe; Fiscal Year: 2006
    ..The proposed Aims will address important mechanistic considerations on IDRE-independent inhibitory AhR-ERa crosstalk and pathways critical for inhibition of mammary tumor growth by SAhRMs. ..
  57. Training in Alternative Tropical Botanical Medicine
    BRADLEY BENNETT; Fiscal Year: 2005
    ..Our training prepares researchers for careers devoted to the study of tropical botanical medicines and our research focuses examines many of the poorly known plants that are widely used in the region. ..
  58. Bioavailability of Tea Polyphenols in Prostate Cancer
    Susanne Henning; Fiscal Year: 2002
    ..ODC enzyme activity will be determined measuring the release of 14C CO2 from 14C ornithine. These studies will provide information important in designing studies to critically test the role of dietary supplementation in prostate cancer. ..
  59. Botanicals from Central America for Menopause
    Gail Mahady; Fiscal Year: 2005
    ..Successful validation and standardization of traditional plant-based medicines used to treat menopause has great significance not only for the women of Central America but the rest of the world as well. ..
  60. Tea Polyphenols in Chemoprevention of Prostate Cancer
    SUSANNE MARGARETE HENNING; Fiscal Year: 2011
    ..The results will assist in designing dietary supplements for chemoprevention of early stages of prostate cancer or during watchful waiting. ..
  61. Calcium, Dairy, and Body Fat in Adolescents
    Connie Weaver; Fiscal Year: 2006
    ..This study will evaluate calcium/dairy as a modulator of energy balance, important to the management of body fat in children. ..
  62. Nutritional Supplements and Cancer Chemoprevention
    JOHN PEZZUTO; Fiscal Year: 2002
    ..Attracting the attention of these participants should provide a valuable pedagogical experience and help to foster additional progress in the field of cancer chemoprevention. ..
  63. Emerging Trends of Tryptamine Use: Contexts & Risks
    Brian Kelly; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  64. Club Drug Initiation & HIV Risk of Mobile Suburban Youth
    Brian Kelly; Fiscal Year: 2003
    ..Determining the pathways to club drug initiation and transitions to later stages of use and abuse is, therefore, of utmost importance. ..
  65. 24,25-DIHYDROXYVITAMIN D: MARKER OF SALT SENSITIVITY
    Connie Weaver; Fiscal Year: 2001
    ..Furthermore, they should provide an explanation for the paradox that blacks can build higher bone density, have a lower rate of bone turnover, and excrete less urinary calcium on the same sodium loads compared to whites. ..
  66. CALCIUM METABOLISM IN ASIAN GIRLS AND POSTMENOPAUSAL WOMEN
    Connie Weaver; Fiscal Year: 2006
    ..Optimizing calcium retention during periods of rapid growth is a key nutritional strategy to build peak bone mass and reduce lifelong risk of osteoporosis. ..
  67. SIGNIFICANCE OF GGT EXPRESSION IN TUMORS
    MARIE HANIGAN; Fiscal Year: 2008
    ..The goal of this research is to understand the molecular mechanisms by which cisplatin kills cells and the mechanism by which cells become resistant to cisplatin. ..