- Identification and cloning potentially protective antigens of Coxiella burnetii using sera from mice experimentally infected with Nine Mile phase I
G Q Zhang
Department of Medical Microbiology and Immunology, Texas A M University System Health Science Center, College Station, Texas 77843 1114, USA
Ann N Y Acad Sci 990:510-20. 2003
..Further characterization of these proteins will provide essential information for developing novel, specific diagnostic reagents and potential subunit vaccine candidates against C. burnetii infection...
- Tularemia as a biological weapon: medical and public health management
D T Dennis
Division of Vector Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, PO Box 2087, Fort Collins, CO 80522, USA
JAMA 285:2763-73. 2001
..The Working Group on Civilian Biodefense has developed consensus-based recommendations for measures to be taken by medical and public health professionals if tularemia is used as a biological weapon against a civilian population...
- Tularaemia: bioterrorism defence renews interest in Francisella tularensis
Petra C F Oyston
Dstl Porton Down, Salisbury, Wiltshire, SP4 0JQ, UK
Nat Rev Microbiol 2:967-78. 2004
..This is a reflection of the increased funding of research on this pathogen, particularly in the United States...
- Vaccination with Clostridium perfringens recombinant proteins in combination with Montanide™ ISA 71 VG adjuvant increases protection against experimental necrotic enteritis in commercial broiler chickens
Seung I Jang
Animal Parasitic Diseases Laboratory, Animal and Natural Resources Institute, Agricultural Research Service US Department of Agriculture, Beltsville, MD 20705, USA
Vaccine 30:5401-6. 2012
..These results suggest that vaccination with clostridial recombinant proteins, particularly NetB toxin or PFO, in combination with ISA 71 VG enhances protective immunity against experimental necrotic enteritis in broiler chickens...
- A naturally derived outer-membrane vesicle vaccine protects against lethal pulmonary Burkholderia pseudomallei infection
Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA, USA
Vaccine 29:8381-9. 2011
..pseudomallei that can be exploited for other intracellular respiratory pathogens, including other Burkholderia and bacteria capable of establishing persistent infection...
- Leptospira: the dawn of the molecular genetics era for an emerging zoonotic pathogen
Albert I Ko
Division of Infectious Disease, Weill Medical College of Cornell University, New York, New York 10021, USA
Nat Rev Microbiol 7:736-47. 2009
..We discuss the life cycle of the bacterium, the recent advances in our understanding and the implications for the future prevention of leptospirosis...
- Control of Mycoplasma hyopneumoniae infections in pigs
Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium
Vet Microbiol 126:297-309. 2008
..Eradication of the infection at herd level based on age-segregation and medication is possible, but there is a permanent risk for re-infections...
- Progress toward development of vaccines against melioidosis: A review
Defence Science and Technology Laboratory, Salisbury, United Kingdom
Clin Ther 32:1437-45. 2010
..Treatment is often unsuccessful, with infection frequently relapsing. Burkholderia pseudomallei, the etiologic agent of melioidosis, is inherently resistant to many antibiotics...
- Evaluation of lipopolysaccharide and capsular polysaccharide as subunit vaccines against experimental melioidosis
Defence Science and Technology Laboratory, Porton Down, Salisbury SP4 0JQ, UK
J Med Microbiol 53:1177-82. 2004
..This study is the first time antigens protective by active immunization have been identified and suggests that polysaccharides have potential as vaccine candidates against melioidosis...
- Efficacy of a killed vaccine for the control of paratuberculosis in Australian sheep flocks
NSW Department of Primary Industries, PMB 8, Camden, NSW 2570, Australia
Vet Microbiol 115:77-90. 2006
..Data from this trial enabled the registration of Gudair in Australia in 2002 and underpins the pivotal role of vaccination in the current management of OJD...
- Immunization with the recombinant Burkholderia pseudomallei outer membrane protein Omp85 induces protective immunity in mice
Yu Ching Su
School of Biosciences and Biotechnology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600 UKM Bangi, Selangor Darul Ehsan, Malaysia
Vaccine 28:5005-11. 2010
..pseudomallei by human polymorphonuclear cells. In conclusion, we demonstrated that B. pseudomallei Omp85 is potentially able to induce protective immunity against melioidosis...
- Brucellosis vaccines: past, present and future
Gerhardt G Schurig
Center for Molecular Medicine and Infectious Diseases, Virginia Maryland Regional College of Veterinary Medicine, Virginia Tech, Blacksburg, VA 24061, USA
Vet Microbiol 90:479-96. 2002
..Limited success has been obtained with these or with DNA vaccines encoding known protective antigens in experimental models and further work is indicated...
- ATP-binding cassette transporters are targets for the development of antibacterial vaccines and therapies
Helen S Garmory
Department of Biomedical Sciences, Defence Science and Technology Laboratory, Porton Down, Salisbury SP4 0JQ, United Kingdom
Infect Immun 72:6757-63. 2004
- Vaccine assembly from surface proteins of Staphylococcus aureus
Yukiko K Stranger-Jones
Department of Microbiology, University of Chicago, 920 East 58th Street, Chicago, IL 60637, USA
Proc Natl Acad Sci U S A 103:16942-7. 2006
..When assembled into a combined vaccine, the four surface proteins afforded high levels of protection against invasive disease or lethal challenge with human clinical S. aureus isolates...
- Recombinant Bacillus subtilis expressing the Clostridium perfringens alpha toxoid is a candidate orally delivered vaccine against necrotic enteritis
Tran H Hoang
School of Biological Sciences, Royal Holloway, University of London, Egham, Surrey TW20 0EX, United Kingdom
Infect Immun 76:5257-65. 2008
..Existing use of spores as competitive exclusion agents in animal feeds supports their use as a potentially economical and heat-stable vaccine for the poultry industry...
- Immunity to murine chlamydial genital infection
Richard P Morrison
Department of Microbiology, Montana State University, Bozeman 59717, USA
Infect Immun 70:2741-51. 2002
- Immunogenicity of a Salmonella typhimurium aroA aroD vaccine expressing a nontoxic domain of Clostridium difficile toxin A
S J Ward
Microbial Pathogenicity Research Group, Department of Microbiology, St Bartholomew s and the Royal London School of Medicine and Dentistry, London EC1A 7BE, United Kingdom
Infect Immun 67:2145-52. 1999
..The availability of live attenuated Salmonella typhi for human use may allow the development of a multivalent mucosal vaccine against CDAD, tetanus, and typhoid...
- Antigenic and genetic heterogeneity of Borrelia burgdorferi populations transmitted by ticks
Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27599, USA
Proc Natl Acad Sci U S A 98:670-5. 2001
..burgdorferi transmission. Implicit in our model is the concept that tick transmission converts a homogeneous spirochete population into a heterogeneous population that is poised to infect the mammalian host...
- Melioidosis vaccines: a systematic review and appraisal of the potential to exploit biodefense vaccines for public health purposes
Sharon J Peacock
Department of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
PLoS Negl Trop Dis 6:e1488. 2012
..Here, we discuss target populations for vaccination, consider the cost-benefit of different vaccination strategies and review potential vaccine candidates...
- Molecular immune responses to aerosol challenge with Francisella tularensis in mice inoculated with live vaccine candidates of varying efficacy
Institute for Biological Sciences, National Research Council Canada, Ottawa, Ontario, Canada
PLoS ONE 5:e13349. 2010
..A live vaccine strain (LVS) derived from the less virulent holarctica subspecies confers incomplete protection against aerosol challenge with subsp. tularensis. Moreover, correlates of protection have not been established for LVS...
- Antigen selection based on expression levels during infection facilitates vaccine development for an intracellular pathogen
Department of Molecular Biology, Max Planck Institute for Infection Biology, Schumannstrasse 21 22, D 10117 Berlin, Germany
Proc Natl Acad Sci U S A 101:8739-44. 2004
..In conclusion, we have established a rationale and an experimental strategy that will substantially facilitate vaccine development for Salmonella and possibly other intracellular pathogens...
- Lipopolysaccharide from Burkholderia thailandensis E264 provides protection in a murine model of melioidosis
Sarah A Ngugi
Dstl Porton Down, Salisbury, Wiltshire SP4 0JQ, UK
Vaccine 28:7551-5. 2010
..Similar protection levels were observed when either LPS was used as the immunogen. This data suggests that B. thailandensis LPS has the potential to be used as part of a subunit based vaccine against pathogenic B. pseudomallei...
- Tularemia in BALB/c and C57BL/6 mice vaccinated with Francisella tularensis LVS and challenged intradermally, or by aerosol with virulent isolates of the pathogen: protection varies depending on pathogen virulence, route of exposure, and host genetic back
National Research Council Canada, Institute for Biological Sciences, Ottawa, Ont, Canada K1A 0R6
Vaccine 21:3690-700. 2003
..tularensis. Neither mouse strain immunized with LVS was able to resist aerosol challenge with Type A F. tularensis, and only immunized BALB/c mice withstood exposure to aerosols of Type B F. tularensis...
- The Burkholderia pseudomallei Δasd mutant exhibits attenuated intracellular infectivity and imparts protection against acute inhalation melioidosis in mice
Michael H Norris
Department of Microbiology, University of Hawaii at Manoa, Manoa, HI, 96822, USA
Infect Immun 79:4010-8. 2011
..Thus, the B. pseudomallei Δasd mutant may be a promising live attenuated vaccine strain and a biosafe strain for consideration of exclusion from the select agent list...
- Killed but metabolically active microbes: a new vaccine paradigm for eliciting effector T-cell responses and protective immunity
D G Brockstedt
Cerus Corporation, 2411 Stanwell Drive, Concord, California 94520, USA
Nat Med 11:853-60. 2005
..Microbial KBMA vaccines used either as a recombinant vaccine platform or as a modified form of the pathogen itself may have broad use for the treatment of infectious disease and cancer...
- Francisella tularensis: unravelling the secrets of an intracellular pathogen
Petra C F Oyston
Biomedical Sciences, Dstl Porton Down, Salisbury, Wiltshire SP4 0JQ, UK
J Med Microbiol 57:921-30. 2008
..tularensis pathogenicity, and will facilitate the development of a vaccine to protect against infection...
- Vaccination with the Chlamydia trachomatis major outer membrane protein can elicit an immune response as protective as that resulting from inoculation with live bacteria
Department of Pathology and Laboratory Medicine, Medical Sciences I, Room D440, University of California, Irvine, Irvine, CA 92697 4800, USA
Infect Immun 73:8153-60. 2005
..05). In conclusion, immunization with a purified preparation of the MOMP is as effective as vaccination with viable C. trachomatis in eliciting a protective immune response against a genital challenge in mice...
- Staphylococcus aureus capsular polysaccharides
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Clin Microbiol Rev 17:218-34. 2004
..aureus vaccine. The genetics and mechanisms of capsule biosynthesis are complex, and much work remains to enhance our understanding of capsule biosynthesis and its regulation...
- Lung CD4-CD8- double-negative T cells are prominent producers of IL-17A and IFN-gamma during primary respiratory murine infection with Francisella tularensis live vaccine strain
Siobhán C Cowley
Division of Bacterial, Parasitic and Allergenic Products, Laboratory of Mycobacterial Diseases and Cellular Immunology, Center for Biologics Evaluation and Research, U S Food and Drug Administration, Rockville, MD 20852, USA
J Immunol 184:5791-801. 2010
- Polysaccharides and virulence of Burkholderia pseudomallei
Defence Science and Technology Laboratory, Porton Down, Salisbury SP4 0JQ, UK
J Med Microbiol 56:1005-10. 2007
..However, immunization with killed polysaccharide mutant strains conferred different degrees of protection, demonstrating the immunological importance of the polysaccharide clusters on the surface of B. pseudomallei...
- Nonviable Burkholderia mallei induces a mixed Th1- and Th2-like cytokine response in BALB/c mice
Pathogenesis and Immunology Branch, Bacteriology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland 21702, USA
Infect Immun 70:2319-25. 2002
..This may be the reason for the inability of the B. mallei cells that were examined as candidate vaccines to protect the mice from a live challenge...
- Identification of an essential Francisella tularensis subsp. tularensis virulence factor
Department of Medicine, University of Virginia, Charlottesville, Virginia 22908, USA
Infect Immun 77:152-61. 2009
..These experiments identified the FTT1103 protein as an essential virulence factor and also demonstrated the feasibility of creating defined attenuated vaccines based on a type A strain...
- Susceptibility to secondary Francisella tularensis live vaccine strain infection in B-cell-deficient mice is associated with neutrophilia but not with defects in specific T-cell-mediated immunity
C M Bosio
Laboratory of Mycobacteria, Division of Bacterial, Parasitic, and Allergenic Products, Center for Biologics, Evaluation, and Research, Food and Drug Administration, Rockville, Maryland 20852, USA
Infect Immun 69:194-203. 2001
..The neutrophilia was directly associated with B cells, since BKO mice reconstituted with naive B cells prior to a secondary challenge with LVS had decreased bacterial loads and neutrophils in the spleen and survived...
- The terminal portion of leptospiral immunoglobulin-like protein LigA confers protective immunity against lethal infection in the hamster model of leptospirosis
Everton F Silva
Gonçalo Moniz Research Centre, Oswaldo Cruz Foundation, Brazilian Ministry of Health, Salvador, Brazil
Vaccine 25:6277-86. 2007
..These findings indicate that the carboxy-terminal portion of LigA is an immunoprotective domain and may serve as a vaccine candidate for human and veterinary leptospirosis...
- Essential protective role attributed to the surface lipoproteins of Borrelia burgdorferi against innate defences
Department of Pathobiological Sciences, Louisiana State University, Baton Rouge, LA 70803, USA
Mol Microbiol 69:15-29. 2008
..Taken together, the study demonstrated that the surface lipoproteins provide B. burgdorferi with an essential protective function against host innate elimination...
- Cellular and humoral immunity are synergistic in protection against types A and B Francisella tularensis
Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115, USA
Vaccine 27:597-605. 2009
..tularensis and provide important insight into the development of a safer vaccine effective against infections caused by clinical type A and B strains of F. tularensis...
- A specific role for B cells in the generation of CD8 T cell memory by recombinant Listeria monocytogenes
Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
J Immunol 170:1443-51. 2003
..Elucidation of factors that regulate the death phase may allow us to manipulate this process to increase the level of immunological memory and thus, vaccine efficacy...
- Outer surface protein A protects Lyme disease spirochetes from acquired host immunity in the tick vector
James M Battisti
Rocky Mountain Laboratories, NIAID, NIH, 903 S 4th Street, Hamilton, MT 59840, USA
Infect Immun 76:5228-37. 2008
..We conclude that OspA serves a critical antibody-shielding role during vector blood meal uptake from immune hosts and is not required for persistence in the tick vector...
- Temporal regulation of outer surface proteins of the Lyme-disease spirochaete Borrelia burgdorferi
T G Schwan
Laboratory of Human Bacterial Pathogenesis, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 South 4th Street, Hamilton, MT 59840, USA
Biochem Soc Trans 31:108-12. 2003
..Future experiments in ticks with mutant spirochaetes that lack these proteins should clarify the speculative functions currently given to these proteins...
- Vaccination against paratuberculosis
WIV Pasteur Institute Brussels, Laboratory of Mycobacterial Immunology, 642 Engelandstraat, B1180 Brussels, Belgium
Expert Rev Vaccines 7:817-32. 2008
..It provides an overview of the existing MAP vaccines and comments on the development of second-generation subunit vaccines based on new technologies...
- Immune responses in mice to Mycobacterium avium subsp. paratuberculosis following vaccination with a novel 74F recombinant polyprotein
Li Hsuen Chen
College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Vaccine 26:1253-62. 2008
..Results of this study indicated that immunization of mice with Map74F protected mice against MAP infection...
- Variable protection after vaccination of broiler chickens against necrotic enteritis using supernatants of different Clostridium perfringens strains
Department of Pathology, Bacteriology and Avian Diseases, Research Group Veterinary Public Health and Zoonoses, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, Merelbeke, Belgium
Vaccine 28:5920-3. 2010
..Our results indicate that the protective characteristics of the supernatants are not solely based on the presence of NetB or alpha toxin...
- Evaluation of the trimeric autotransporter Ata as a vaccine candidate against Acinetobacter baumannii infections
Leticia V Bentancor
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Infect Immun 80:3381-8. 2012
..The ability of Ata to engender anti-adhesive, bactericidal, opsonophagocytic, and protective antibodies validates its potential use as an antigenic target against MDR A. baumannii infections...
- Safety and efficacy of a maternal vaccine for the passive protection of broiler chicks against necrotic enteritis
C F Crouch
Intervet Schering Plough Animal Health, Walton Manor, Walton, Milton Keynes, UK
Avian Pathol 39:489-97. 2010
..These results indicate that, under commercial conditions, maternal vaccination with Netvax™ can help to control losses related to necrotic enteritis...
- Gene expression profiling in naïve and vaccinated rainbow trout after Yersinia ruckeri infection: insights into the mechanisms of protection seen in vaccinated fish
Nor Omaima Harun
Scottish Fish Immunology Research Centre, University of Aberdeen, Institute of Biological and Environmental Sciences, Tillydrone Avenue, Aberdeen AB24 2TZ, Scotland, UK
Vaccine 29:4388-99. 2011
..Thus, it is possible that different types of adaptive responses are on-going within the vaccinated fish during infection with Y. ruckeri, potentially affected by the site and stage of infection...
- Evaluation of two mutants of Mycobacterium avium subsp. paratuberculosis as candidates for a live attenuated vaccine for Johne's disease
Kun Taek Park
Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman, WA 99164, United States
Vaccine 29:4709-19. 2011
..The mutant also elicited an immune response that limited colonization by challenge wild type Map. The findings show the relA mutant is a good candidate for development of a live attenuated vaccine for Johne's disease...
- Structure-based approach to rationally design a chimeric protein for an effective vaccine against Group B Streptococcus infections
Novartis Vaccines and Diagnostics, 53100 Siena, Italy
Proc Natl Acad Sci U S A 108:10278-83. 2011
..In addition, this work describes a template procedure that can be followed to develop vaccines against other bacterial pathogens...
- Identification of Francisella tularensis outer membrane protein A (FopA) as a protective antigen for tularemia
Anthony J Hickey
Albany Medical College, Center for Immunology and Microbial Disease, Albany, NY 12208, USA
Vaccine 29:6941-7. 2011
..tularensis; however, the findings demonstrate proof of principle that an immune response generated against a component of a subunit vaccine is protective against lethal respiratory and intradermal tularemia...
- Partial protection against chlamydial reproductive tract infection by a recombinant major outer membrane protein/CpG/cholera toxin intranasal vaccine in the guinea pig Chlamydia caviae model
Dean W Andrew
Infectious Diseases Program, Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Brisbane 4059, Australia
J Reprod Immunol 91:9-16. 2011
..This data demonstrates the value of using the guinea pig model to evaluate potential chlamydial vaccines for protection against infection and disease pathology caused by C. trachomatis in the female reproductive tract...
- Protection against Acinetobacter baumannii infection via its functional deprivation of biofilm associated protein (Bap)
Department of Biology, Shahed University, Tehran Qom Express Way, Opposite Imam Khomeini s Shrine, Tehran 3319118651, Iran
Microb Pathog 51:402-6. 2011
..Immunodominant region of Bap possesses target sites for a protective humoral immune response to A. baumannii. This seems to be a conserved region erecting efficacy of Bap as an appropriate vaccine candidate...
- Efficacy of two vaccine formulations against contagious bovine pleuropneumonia (CBPP) in Kenyan indigenous cattle
Kenya Agricultural Research Institute, Veterinary Research Centre, P O Box 32, 00902 Kikuyu, Kenya
Res Vet Sci 93:568-73. 2012
..Because of its longer half life after reconstitution, the modified vaccine might be preferred in field situations where the reconstituted vaccine is likely not to be administered immediately...
- Protective immunity against mouse upper genital tract pathology correlates with high IFNγ but low IL-17 T cell and anti-secretion protein antibody responses induced by replicating chlamydial organisms in the airway
Department of Microbiology and Immunology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
Vaccine 30:475-85. 2012
..These observations have provided important information on how to develop subunit vaccines for inducing protective immunity against urogenital infection with Chlamydia trachomatis organisms...
- Multi high-throughput approach for highly selective identification of vaccine candidates: the Group A Streptococcus case
Novartis Vaccines and Diagnostics, Via Fiorentina 1, 53100 Siena, Italy
Mol Cell Proteomics 11:M111.015693. 2012
We propose an experimental strategy for highly accurate selection of candidates for bacterial vaccines without using in vitro and/or in vivo protection assays...
- Serotype-independent pneumococcal experimental vaccines that induce cellular as well as humoral immunity
Division of Infectious Diseases, Department of Medicine, Children s Hospital Boston and Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 109:3623-7. 2012
..Such constructs induce accelerated clearance when given intranasally and induce both immune mechanisms when injected. The defined composition permits analysis of structure-function activity...
- Identification of CD4+ T cell epitopes in C. burnetii antigens targeted by antibody responses
Department of Microbial and Molecular Pathogenesis, Texas A and M Health Science Center, College Station, Texas, United States of America
PLoS ONE 6:e17712. 2011
..This suggests that a complete map of CD4(+) response targets in PI-WCV vaccinated mice will likely include antigens against which no antibody responses are made...
- Chlamydia muridarum T-cell antigens formulated with the adjuvant DDA/TDB induce immunity against infection that correlates with a high frequency of gamma interferon (IFN-gamma)/tumor necrosis factor alpha and IFN-gamma/interleukin-17 double-positive CD4+
British Columbia Centre for Disease Control, Vancouver, BC, Canada
Infect Immun 78:2272-82. 2010
- Identification of Francisella tularensis live vaccine strain CuZn superoxide dismutase as critical for resistance to extracellularly generated reactive oxygen species
Amanda A Melillo
Center for Immunology and Microbial Disease, MC 151, Albany Medical College, 47 New Scotland Ave, Albany, NY 12208, USA
J Bacteriol 191:6447-56. 2009
..To conclude, this study demonstrates that SodB and SodC act to confer protection against host-derived oxidants and contribute to intramacrophage survival and virulence of F. tularensis in mice...
- Protective efficacy of heat-inactivated B. thailandensis, B. mallei or B. pseudomallei against experimental melioidosis and glanders
Defence Science and Technology Laboratory, Porton Down, Salisbury, Wiltshire, SP4 OJQ, UK
Vaccine 27:4447-51. 2009
..These studies indicate the longer term potential for heat-inactivated bacteria to be developed as vaccines against melioidosis and glanders...
- Immunogenic Burkholderia pseudomallei outer membrane proteins as potential candidate vaccine targets
Malaysia Genome Institute, UKM MTDC Smart Technology Centre, Bangi, Selangor, Malaysia
PLoS ONE 4:e6496. 2009
..There is no vaccine towards the bacterium available in the market, and the efficacy of many of the bacterium's surface and secreted proteins are currently being evaluated as vaccine candidates...
- A multi-subunit chlamydial vaccine induces antibody and cell-mediated immunity in immunized koalas (Phascolarctos cinereus): comparison of three different adjuvants
Alison J Carey
Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, QLD, Australia
Am J Reprod Immunol 63:161-72. 2010
..Little is known about the immune response in koalas, or the safety of commonly used adjuvants for induction of protective systemic and mucosal immunity...
- Identification of immunogenic proteins from Burkholderia cepacia secretome using proteomic analysis
Department of Medical Microbiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
Vaccine 28:1318-24. 2010
..Eighteen of these immunogenic proteins which reacted with all three antibodies were identified and might be potential molecules as a diagnostic marker or a putative candidate vaccine against B. cepacia infections...
- Directed mutagenesis of the Rickettsia prowazekii pld gene encoding phospholipase D
Lonnie O Driskell
Department of Microbiology and Immunology, University of South Alabama College of Medicine, Mobile, 36688 0002, USA
Infect Immun 77:3244-8. 2009
..This study demonstrates the feasibility of generating site-directed rickettsial gene mutants, providing a new tool for understanding rickettsial biology and furthering advances in the prevention of epidemic typhus...
- Persistence of mucosal and systemic immune responses following sublingual immunization
Donatella R M Negri
Department of Infectious, Parasitic and Immune Mediated Diseases, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
Vaccine 28:4175-80. 2010
- Canine leptospirosis--do we have a problem?
Ecole Nationale Veterinaire de Nantes, Bacteriologie Medicale et Moleculaire des Leptospires B2ML, Route de Gachet, BP 40706, 44307 Nantes Cedex 03, France
Vet Microbiol 117:19-24. 2006
..In a survey on 98 ill cats, 48% were positive in microagglutination test (MAT) to Leptospira spp., showing that this infection is also frequent in the feline species...
- Leptospira and leptospirosis
Australian Research Council Centre of Excellence in Structural and Functional Microbial Genomics, Monash University, Clayton, Australia
Vet Microbiol 140:287-96. 2010
..However, the recent development of defined mutagenesis systems for Leptospira heralds the potential for gaining a much improved understanding of pathogenesis in leptospirosis...
- Mannheimia haemolytica and bovine respiratory disease
J A Rice
Dow AgroSciences, Indianapolis, IN, USA
Anim Health Res Rev 8:117-28. 2007
..haemolytica pneumonia. Effective control of M. haemolytica pneumonia is likely to require a combination of more definitive diagnosis, efficacious vaccines, therapeutic intervention and improved management practices...
- An improved vaccine for prevention of respiratory tularemia caused by Francisella tularensis SchuS4 strain
Chandra Shekhar Bakshi
Center for Immunology and Microbial Disease, Albany Medical College, Albany, NY 12208, USA
Vaccine 26:5276-88. 2008
..Collectively, this study describes an improved live vaccine candidate against respiratory tularemia that has an attenuated virulence and enhanced protective efficacy than the LVS...
- Aerosol-, but not intradermal-immunization with the live vaccine strain of Francisella tularensis protects mice against subsequent aerosol challenge with a highly virulent type A strain of the pathogen by an alphabeta T cell- and interferon gamma- depende
J Wayne Conlan
National Research Council Canada, Institute for Biological Sciences, Ottawa, Ont, Canada K1A 0R6
Vaccine 23:2477-85. 2005
..Further, understanding of how inhaled LVS elicits local cell-mediated protective immunity will be critical for devising improved vaccines against pulmonary tularemia...
- Analysis of peptide mimotopes of Burkholderia pseudomallei exopolysaccharide
Joseph B Legutki
Department of Microbiology, The Ohio State University, 484 W 12th Ave Rm 376, Columbus, OH 43210, United States
Vaccine 25:7796-805. 2007
..00 days over the 2.18 days afforded by immunization with thyroglobulin alone. This mimotope may be of use in developing an antibody response against B. pseudomallei exopolysaccharide...
- Comparison of the abilities of different attenuated Salmonella typhimurium strains to elicit humoral immune responses against a heterologous antigen
S J Dunstan
Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria, Australia
Infect Immun 66:732-40. 1998
- IFN-β mediates suppression of IL-12p40 in human dendritic cells following infection with virulent Francisella tularensis
Timothy J Bauler
Immunity to Pulmonary Pathogens Section, Laboratory of Intracellular Parasites Rocky Mountain Laboratories National Institute of Allergy and Infectious Disease National Institutes of Health, Hamilton, MT 59840, USA
J Immunol 187:1845-55. 2011
..Together, these data demonstrated a novel mechanism by which virulent bacteria, in contrast to attenuated strains, modulate human cells to cause disease...
- Safety, reactogenicity and immunogenicity of Francisella tularensis live vaccine strain in humans
H M El Sahly
Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, United States
Vaccine 27:4905-11. 2009
- Tularemia: history, epidemiology, pathogen physiology, and clinical manifestations
Department of Clinical Bacteriology, Clinical Microbiology, Umea University, SE 901 85 Umea, Sweden
Ann N Y Acad Sci 1105:1-29. 2007
..This article summarizes, predominantly with a historical perspective, the epidemiology and clinical manifestations of tularemia and the physiology of F. tularensis...
- Bactericidal monoclonal antibodies that define unique meningococcal B polysaccharide epitopes that do not cross-react with human polysialic acid
D M Granoff
Chiron Vaccines, Emeryville, CA 94608, USA
J Immunol 160:5028-36. 1998
..These Abs may be useful for the identification of molecular mimetics capable of eliciting protective Abs specific to the bacteria, without the risk of evoking autoimmune disease...
- Prevention of Coxiella burnetii shedding in infected dairy herds using a phase I C. burnetii inactivated vaccine
Ecole Nationale Veterinaire de Nantes, UMR 1300 Bio Agression, Epidémiologie et Analyse de Risque, F 44307 Nantes, France
Vaccine 26:4320-8. 2008
..e. at least the heifers. The vaccination of the dairy cows should be performed when the within-herd seroprevalence is low, i.e. in herds where the infection has not spread widely yet...
- Effective induction of protective systemic immunity with nasally administered vaccines adjuvanted with IL-1
William M Gwinn
Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA
Vaccine 28:6901-14. 2010
- Reintroduction of two deleted virulence loci restores full virulence to the live vaccine strain of Francisella tularensis
FOI Swedish Defence Research Agency, Division of CBRN Defence and Security, Umea, Sweden
Infect Immun 77:3424-31. 2009
..The identification of the two attenuating deletion events could facilitate the licensing of LVS for use in humans...
- Human health benefits from livestock vaccination for brucellosis: case study
Swiss Centre for International Health, Swiss Tropical Institute, Basle, Switzerland
Bull World Health Organ 81:867-76. 2003
..To estimate the economic benefit, cost-effectiveness, and distribution of benefit of improving human health in Mongolia through the control of brucellosis by mass vaccination of livestock...
- Effect of vaccination with phase I and phase II Coxiella burnetii vaccines in pregnant goats
INRA, Pathologie Infectieuse et Immunologie, F 37380 Nouzilly, France
Vaccine 23:4392-402. 2005
..Phase I vaccine was effective and dramatically reduced both abortion and excretion of bacteria in the milk, vaginal mucus and feces. In contrast, the phase II vaccine did not affect the course of the disease or excretion...
- Recombinant attenuated Salmonella enterica serovar typhimurium expressing the carboxy-terminal domain of alpha toxin from Clostridium perfringens induces protective responses against necrotic enteritis in chickens
The Biodesign Institute, Center for Infectious Diseases and Vaccinology, Arizona State University, 1001 S McAllister, Tempe, AZ 85287 5401, USA
Clin Vaccine Immunol 15:805-16. 2008
..RASV-immunized chickens had reduced intestinal mucosal pathology after challenge with virulent C. perfringens. These results indicate that oral RASV expressing an alpha toxin C-terminal peptide induces protective immunity against NE...
- Two Listeria monocytogenes vaccine vectors that express different molecular forms of human papilloma virus-16 (HPV-16) E7 induce qualitatively different T cell immunity that correlates with their ability to induce regression of established tumors immortal
G R Gunn
Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
J Immunol 167:6471-9. 2001
..These studies demonstrate the complexity of L. monocytogenes-mediated tumor immunotherapy targeting the human tumor Ag, HPV-16 E7...
- Current status of veterinary vaccines
Els N T Meeusen
Animal Biotechnology Research Laboratories, Department of Physiology, Building 13F, Monash University, Clayton, Victoria 3800, Australia
Clin Microbiol Rev 20:489-510, table of contents. 2007
..The continued interaction between animals and human researchers and health professionals will be of major importance for adapting new technologies, providing animal models of disease, and confronting new and emerging infectious diseases...
- Actinobacillus pleuropneumoniae surface polysaccharides: their role in diagnosis and immunogenicity
J D Dubreuil
Groupe de Recherche sur les Maladies Infectieuses du Porc, Faculte de Medecine Veterinaire, Universite de Montreal, Saint Hyacinthe, Quebec, Canada
Anim Health Res Rev 1:73-93. 2000
..Here, we review current knowledge on CPS and LPS of A. pleuropneumoniae used as diagnostic tools to monitor the infection and as immunogens for inclusion in vaccine preparations for animal protection...
- Innate and adaptive immune responses to an intracellular bacterium, Francisella tularensis live vaccine strain
Karen L Elkins
Laboratory of Mycobacteria, Division of Bacterial, Parasitic, and Allergenic Products, Center for Biologics Evaluation and Research, US Food and Drug Administration, 1401 Rockville Pike, HFM 431, Rockville, MD 20852, USA
Microbes Infect 5:135-42. 2003
..Here we review this infection model, which provides a convenient means of studying protective immune mechanisms not only for Francisella, but also for the large and important class of intracellular pathogens...
- Induction of protective immunity against Burkholderia pseudomallei using attenuated mutants with defects in the intracellular life cycle
Friedrich Loeffler Institute of Medical Microbiology, Ernst Moritz Arndt University Greifswald, Martin Luther Str 6, 17489 Greifswald, Germany
Trans R Soc Trop Med Hyg 102:S89-94. 2008
..Further studies are required to analyze the precise nature of the immune response induced by the various live attenuated vaccines with different protective potential...
- Host immunity in the protective response to vaccination with heat-killed Burkholderia mallei
Gregory C Whitlock
Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA
BMC Immunol 9:55. 2008
..We performed initial cell, cytokine and complement depletion studies to investigate the possible role of these effectors in response to vaccination with heat-killed Burkholderia mallei in a susceptible BALB/c mouse model of infection...
- Utilization of Fc receptors as a mucosal vaccine strategy against an intracellular bacterium, Francisella tularensis
Deepak B Rawool
Center for Immunology and Microbial Disease, Albany Medical College, Albany, NY 12208, USA
J Immunol 180:5548-57. 2008
..tularensis, a category A biothreat agent. In summary, these studies show for the first time the use of FcRs as a highly effective vaccination strategy against a highly virulent mucosal intracellular pathogen...
- Efficacy of vaccines against bacterial diseases in swine: what can we expect?
Department of Pathology, Bacteriology and Poultry Diseases, Faculty of Veterinary Medicine, Ghent University, 9820 Merelbeke, Belgium
Vet Microbiol 100:255-68. 2004
..As an example, vaccination against Salmonella enterica serotype Typhimurium is discussed...
- The continuing challenges of leprosy
D M Scollard
Laboratory Research Branch, National Hansen s Disease Programs, LSU SVM, Skip Bertman Dr, Baton Rouge, LA 70803, USA
Clin Microbiol Rev 19:338-81. 2006
..In nearly all of these areas, however, leprosy remains poorly understood compared to other major bacterial diseases...
- Distribution and genetic variability of three vaccine components in a panel of strains representative of the diversity of serogroup B meningococcus
Novartis V and D, Via Fiorentina 1, 53100 Siena, Italy
Vaccine 27:2794-803. 2009
..Sequencing each gene in the different strains will be important to evaluate antigen conservation and assortment and to allow a future prediction of potential vaccine coverage...
- Colonization factors of human enterotoxigenic Escherichia coli (ETEC)
Dept of Bacteriology, Utrecht University, The Netherlands
Trends Microbiol 4:444-52. 1996
..The ability of ETEC to adhere to the intestinal epithelium of the host is an important virulence determinant, and adhesion is mediated by proteinaceous surface appendages called colonization factors...
- Modulation of virulence factors in Francisella tularensis determines human macrophage responses
Paul E Carlson
Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
Microb Pathog 42:204-14. 2007
..This work provides a basis for investigation of Francisella virulence factor regulation and the identification of additional factors, co-regulated with IglC, that affect macrophage responses...
- Interleukin-17 is a critical mediator of vaccine-induced reduction of Helicobacter infection in the mouse model
Division of Gastroenterology and Hepatology, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland
Gastroenterology 136:2237-2246.e1. 2009
..This study explores the possibility that interleukin (IL)-17 plays a role in the reduction of Helicobacter infection following vaccination of wild-type animals or in spontaneous reduction of bacterial infection in IL-10-deficient mice...
- Clostridium difficile toxoid vaccine in recurrent C. difficile-associated diarrhea
Gastroenterology Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, 02215, USA
Gastroenterology 128:764-70. 2005
..Our aim was to examine whether the vaccine is also well tolerated and immunogenic in patients with recurrent CDAD...
- Vaccination of sheep against M. paratuberculosis: immune parameters and protective efficacy
D J Begg
Disease Research Laboratory, Department of Microbiology and Immunology, University of Otago, P O Box 56, Dunedin, New Zealand
Vaccine 23:4999-5008. 2005
..Immune animals had stronger cell-mediated responses and altered proportions of CD4+, CD8+, CD25+ and B cells in blood, spleen and the gut lymphatics, than diseased animals...
- Bacterial DNA containing CpG motifs stimulates lymphocyte-dependent protection of mice against lethal infection with intracellular bacteria
K L Elkins
Laboratory of Mycobacteria, Division of Bacterial Products, Rockville, MD 20852, USA
J Immunol 162:2291-8. 1999
..These findings indicate that host innate immune responses to bacterial DNA may contribute to the induction of protective immunity to bacteria and the subsequent development of memory...
- Comparison of intranasal and transcutaneous immunization for induction of protective immunity against Chlamydia muridarum respiratory tract infection
Kathryn A Skelding
Discipline of Immunology and Microbiology, School of Biomedical Sciences, Faculty of Health, The University of Newcastle, Callaghan, NSW 2308, Australia
Vaccine 24:355-66. 2006
..The best protection was obtained following IN immunization and correlated with IFNgamma production by mononuclear cells in lung-draining LN and MOMP-specific IgA in BAL...
- Active suppression of the pulmonary immune response by Francisella tularensis Schu4
Catharine M Bosio
Department of Microbiology, Immunology and Pathology, Colorado State University, Ft Collins, CO 80523, USA
J Immunol 178:4538-47. 2007
..tularensis, Schu4 induced broad immunosuppression within the first few days after aerosol infection. This difference may explain the increased virulence of type A strains compared with their more attenuated counterparts...
Defence Science and Technology Laboratory, CBS Porton Down, Salisbury, Wiltshire SP4 0JQ, United Kingdom
Clin Microbiol Rev 15:631-46. 2002
..tularensis. In the absence of a licensed vaccine, aminoglycoside antibiotics play a key role in the prevention and treatment of tularemia...
- Aerogenic vaccination with a Burkholderia mallei auxotroph protects against aerosol-initiated glanders in mice
Ricky L Ulrich
Bacteriology Division, United States Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, MD 21702, USA
Vaccine 23:1986-92. 2005
..Thus, live attenuated strains that promote a Th1-like Ig response may serve as promising vaccine candidates against aerosol infection with B. mallei...
Sharon J Peacock
Wellcome Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
Curr Opin Infect Dis 19:421-8. 2006
..A brief summary of studies relating to genomics and genotyping, immunology and pathogenesis is provided...