- New adjuvants for human vaccines
M Lamine Mbow
Novartis Vaccines and Diagnostics, Cambridge, MA, USA
Curr Opin Immunol 22:411-6. 2010
..This review highlights recent progress of clinically approved vaccine adjuvants and identifies potential novel adjuvants that can broaden the development of new vaccines against infectious diseases.
- Vaccine adjuvants: putting innate immunity to work
Robert L Coffman
Dynavax Technologies Corporation, Berkeley, CA 94710, USA
Immunity 33:492-503. 2010
Adjuvants enhance immunity to vaccines and experimental antigens by a variety of mechanisms...
- Use of defined TLR ligands as adjuvants within human vaccines
Malcolm S Duthie
Infectious Disease Research Institute, Seattle, WA, USA
Immunol Rev 239:178-96. 2011
..Experience with first generation vaccines, as well as rapid advances in developing defined vaccines containing Toll-like receptor ligands (TLRLs), indicate ..
- CpG DNA as a vaccine adjuvant
Cancer and Inflammation Program, National Cancer Institute, Frederick, MD 21702, USA
Expert Rev Vaccines 10:499-511. 2011
..Preclinical studies indicate that CpG ODNs improve the activity of vaccines targeting infectious diseases and cancer...
- Key roles of adjuvants in modern vaccines
Steven G Reed
Infectious Disease Research Institute, Seattle, Washington, USA
Nat Med 19:1597-608. 2013
b>Vaccines containing novel adjuvant formulations are increasingly reaching advanced development and licensing stages, providing new tools to fill previously unmet clinical needs...
- Role of sustained antigen release from nanoparticle vaccines in shaping the T cell memory phenotype
Stacey L Demento
Department of Biomedical Engineering, Yale University, New Haven, CT 06511, USA
Biomaterials 33:4957-64. 2012
Particulate vaccines are emerging promising technologies for the creation of tunable prophylactics against a wide variety of conditions...
- Reverse vaccinology: developing vaccines in the era of genomics
La Jolla Institute for Allergy and Immunology, San Diego, CA 92130, USA
Immunity 33:530-41. 2010
..development of a vaccine against serogroup B meningococcus, and it is now being used for several other bacterial vaccines. In this review, we will first summarize the impact that genome sequencing has had on vaccine development, and ..
- Vaccines for the twenty-first century society
Novartis Vaccines and Diagnostics Srl, Via Fiorentina 5, 53100 Siena, Italy
Nat Rev Immunol 11:865-72. 2011
b>Vaccines have been one of the major revolutions in the history of mankind and, during the twentieth century, they eliminated most of the childhood diseases that used to cause millions of deaths...
- Dendritic cell-targeted protein vaccines: a novel approach to induce T-cell immunity
Laboratory of Cellular Physiology and Immunology and Chris Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, NY 10065, USA
J Intern Med 271:183-92. 2012
Current vaccines primarily work by inducing protective antibodies. However, in many infections like HIV, malaria and tuberculosis as well as cancers, there remains a need for durable and protective T-cell immunity...
- Developing vaccines to combat hookworm infection and intestinal schistosomiasis
Peter J Hotez
Department of Microbiology, Immunology, and Tropical Medicine, George Washington University, Washington, DC 20037, USA
Nat Rev Microbiol 8:814-26. 2010
..The development of vaccines for these infections could substantially reduce the global disability associated with these helminthiases...
- Reverse vaccinology
IRIS, Chiron S p A, Via Fiorentina 1, 53100, Siena, Italy
Curr Opin Microbiol 3:445-50. 2000
..Many vaccines impossible to develop so far will become a reality...
- GlaxoSmithKline Adjuvant Systems in vaccines: concepts, achievements and perspectives
GlaxoSmithKline Biologicals, Research and Development, 1330 Rixensart, Belgium
Expert Rev Vaccines 6:723-39. 2007
..GSK) Biologicals to develop various Adjuvant Systems for the design of prophylactic and therapeutic vaccines. Adjuvant Systems are formulations of classical adjuvants mixed with immunomodulators, specifically adapted to ..
- Vaccines: correlates of vaccine-induced immunity
Stanley A Plotkin
Sanofi Pasteur, Doylestown, Pennsylvania, USA
Clin Infect Dis 47:401-9. 2008
The immune system is redundant, and B and T cells collaborate. However, almost all current vaccines work through induction of antibodies in serum or on mucosa that block infection or interfere with microbial invasion of the bloodstream...
- A small jab - a big effect: nonspecific immunomodulation by vaccines
Christine S Benn
Research Center for Vitamins and Vaccines CVIVA, Statens Serum Institut, Institute of Clinical Research, University of Southern Denmark, and Odense University Hospital, Denmark Electronic address
Trends Immunol 34:431-9. 2013
Recent epidemiological studies have shown that, in addition to disease-specific effects, vaccines against infectious diseases have nonspecific effects on the ability of the immune system to handle other pathogens...
- Understanding immunosenescence to improve responses to vaccines
Jorg J Goronzy
The Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, California, USA
Nat Immunol 14:428-36. 2013
- Designing vaccines based on biology of human dendritic cell subsets
Baylor Institute for Immunology Research, 3434 Live Oak Avenue, Dallas, TX 75204, USA
Immunity 33:464-78. 2010
The effective vaccines developed against a variety of infectious agents, including polio, measles, and hepatitis B, represent major achievements in medicine...
- Prenatal and infant exposure to thimerosal from vaccines and immunoglobulins and risk of autism
Cristofer S Price
Abt Associates Inc, Cambridge, MA, USA
Pediatrics 126:656-64. 2010
Exposure to thimerosal, a mercury-containing preservative that is used in vaccines and immunoglobulin preparations, has been hypothesized to be associated with increased risk of autism spectrum disorder (ASD)...
- Plant-made vaccines for humans and animals
Edward P Rybicki
Department of Molecular and Cell Biology, University of Cape Town, Rondebosch, South Africa ed rybicki uct ac za
Plant Biotechnol J 8:620-37. 2010
The concept of using plants to produce high-value pharmaceuticals such as vaccines is 20 years old this year and is only now on the brink of realisation as an established technology...
- Mucosal immunity and vaccines
Department of Medical Microbiology and Immunology and Göteborg University Vaccine Research Institute, Goteborg University, SE 405 30 Goteborg, Sweden
Nat Med 11:S45-53. 2005
There is currently great interest in developing mucosal vaccines against a variety of microbial pathogens...
- Unmet needs in modern vaccinology: adjuvants to improve the immune response
Centre for Vaccinology, Ghent University and Hospital, Belgium
Vaccine 28:C25-36. 2010
..New vaccine technology has led to vaccines containing highly purified antigens with improved tolerability and safety profiles, but the immune response they ..
- Chloroplast-derived vaccines against human diseases: achievements, challenges and scopes
Andreas G Lössl
Department of Applied Plant Sciences and Plant Biotechnology DAPP, University of Natural Resources and Applied Life Sciences BOKU, Vienna, Austria
Plant Biotechnol J 9:527-39. 2011
..For this reason, different options can be considered for the production of affordable vaccines. Plants have been proved as an alternative expression system for various compounds of biological importance...
- Systems biology approaches to new vaccine development
Ann L Oberg
Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, United States
Curr Opin Immunol 23:436-43. 2011
..applying this approach and its resulting data to expand our knowledge base and drive directed development of new vaccines. We also provide applied examples and point out new directions for the field in order to illustrate the power of ..
- Immunology of gut mucosal vaccines
Marcela F Pasetti
Center for Vaccine Development, University of Maryland School of Medicine, 685 West Baltimore St, Room 480, Baltimore, MD 21201, USA
Immunol Rev 239:125-48. 2011
..oral immunization and the cross-talk between mucosal and systemic immunity should expedite the development of vaccines to diminish the global burden caused by enteric pathogens...
- Cationic liposomes as vaccine adjuvants
Statens Serum Institut, Department of Infectious Disease Immunology, Copenhagen, Denmark
Expert Rev Vaccines 10:513-21. 2011
..In this article we review the recent progress on the application of cationic liposomes as vaccine delivery systems/adjuvants...
- Targeting dendritic cells with biomaterials: developing the next generation of vaccines
Sai T Reddy
Institute of Bioengineering, Ecole Polytechnique Federale de Lausanne EPFL, CH 1015 Lausanne, Switzerland
Trends Immunol 27:573-9. 2006
..in both efficacy and practicality: many chronic diseases cannot yet be addressed by vaccination, and several vaccines that do function well require multiple injections, which is a substantial limitation in various parts of the ..
- Chitosan as a novel nasal delivery system for vaccines
West Pharmaceutical Services, Drug Delivery and Clinical Research Centre Ltd, Albert Einstein Centre, Nottingham Science and Technology Park, NG7 2TN, Nottingham, UK
Adv Drug Deliv Rev 51:81-96. 2001
..our work on the use of the cationic polysaccharide, chitosan as a delivery system for nasally administered vaccines. Several animal studies have been carried out on influenza, pertussis and diphtheria vaccines with good results...
- Adjuvants designed for veterinary and human vaccines
Seppic 75, Quai d Orsay, 75321 Cedex 07, Paris, France
Vaccine 19:2666-72. 2001
Adjuvants play an important role in the efficacy of vaccines as the antigens become more and more purified. Indeed recombinant proteins or synthetic peptides are safer than crude inactivated micro-organism, but less immunogenic...
- Epitope mapping: the first step in developing epitope-based vaccines
Jonathan M Gershoni
Department of Cell Research and Immunology, Tel Aviv University, Tel Aviv, Israel
BioDrugs 21:145-56. 2007
..Thus, understanding the antibody/epitope interaction provides a basis for the rational design of preventive vaccines. It is assumed that immunization with the precise epitope, corresponding to an effective neutralizing antibody, ..
- Epitope-based vaccines: an update on epitope identification, vaccine design and delivery
La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
Curr Opin Immunol 15:461-70. 2003
..Recent advances in understanding the mechanisms of immunodominance thus represent an opportunity to further develop the epitope-based approach...
- Vaccines against intracellular infections requiring cellular immunity
R A Seder
Clinical Immunology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Nature 406:793-8. 2000
b>Vaccines against a variety of infectious diseases represent one of the great triumphs of medicine. The immune correlates of protection induced by most current vaccines seem to be mediated by long-lived humoral immune responses...
- Solar-powered factories for new vaccines and antibiotics
Max Planck Institut fur Molekulare Pflanzenphysiologie, Am Muhlenberg 1, D 14476 Potsdam Golm, Germany
Trends Biotechnol 28:246-52. 2010
..has been made with the chloroplast-based production of two particularly important classes of pharmaceuticals: vaccines and antibiotics...
- Carbohydrate vaccines: developing sweet solutions to sticky situations?
Rena D Astronomo
Department of Immunology and Microbial Science, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
Nat Rev Drug Discov 9:308-24. 2010
..Here, we review the progress being made in addressing challenges posed by targeting the surface carbohydrates of bacteria, protozoa, helminths, viruses, fungi and cancer cells for vaccine purposes...
- Effective induction of high-titer antibodies by viral vector vaccines
Simon J Draper
The Jenner Institute, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Headington, Oxford OX3 7DQ, UK
Nat Med 14:819-21. 2008
Protein-in-adjuvant vaccines have shown limited success against difficult diseases such as blood-stage malaria...
- Viruses as vaccine vectors for infectious diseases and cancer
Simon J Draper
The Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford, OX3 7DQ, UK
Nat Rev Microbiol 8:62-73. 2010
..Viral-vector vaccines remain the best means to induce cellular immunity and are now showing promise for the induction of strong humoral ..
- Efficacy of recombinant birch pollen vaccine for the treatment of birch-allergic rhinoconjunctivitis
University Hospital, Strasbourg, France
J Allergy Clin Immunol 122:951-60. 2008
Recombinant DNA technology has the potential to produce allergen-specific immunotherapy vaccines with defined composition.
- Nanoparticles as potential oral delivery systems of proteins and vaccines: a mechanistic approach
Anne des Rieux
Universite Catholique de Louvain, Unite de Pharmacie Galenique, avenue E Mounier, 73 20, 1200 Brussels, Belgium
J Control Release 116:1-27. 2006
..Encouraging results upon in vivo testing are reported but low bioavailability and lack of control on absorbed dose slow down products development. Vaccines are certainly the most promising applications for orally delivered nanoparticles.
- New vaccines for neglected parasitic diseases and dengue
Coreen M Beaumier
Sabin Vaccine Institute and Texas Children s Hospital Center for Vaccine Development, National School of Tropical Medicine, Baylor College of Medicine, Houston 77030, Tex, USA
Transl Res 162:144-55. 2013
..Preventative and therapeutic NTD vaccines are needed as long-term solutions...
- Co-administration of morphine and oxycodone vaccines reduces the distribution of 6-monoacetylmorphine and oxycodone to brain in rats
Minneapolis Medical Research Foundation, 600 Shapiro Building, 914 8th Street, Minneapolis, MN 55404, USA
Vaccine 30:4617-24. 2012
Opioid conjugate vaccines have shown promise in animal models as a potential treatment for opioid addiction. Individual vaccines are quite specific and each targets only a limited number of structurally similar opioids...
- Biology of immune responses to vaccines in elderly persons
Immunology Division, Institute for Biomedical Aging Research, Austrian Academy of Sciences, Innsbruck, Austria
Clin Infect Dis 46:1078-84. 2008
..Improved vaccination strategies, new adjuvants, and new vaccines that specifically target the aged immune system will help to overcome the limitations of immunosenescence and ..
- Vaccines against drug abuse
X Y Shen
Immunology Allergy and Rheumatology, Department of Medicine, Baylor College of Medicine, Houston, Texas, USA
Clin Pharmacol Ther 91:60-70. 2012
The currently available medications for the treatment of drug abuse have had only limited success. Anti-addiction vaccines, aimed at eliciting antibodies that block the pharmacological effects of drugs, have great potential for treating ..
- Understanding human myeloid dendritic cell subsets for the rational design of novel vaccines
Baylor Institute for Immunology Research, Dallas, Texas, USA
Hum Immunol 70:281-8. 2009
..The biologic raison d'être for separate DC subsets has been the focus of many studies including our own and is being reviewed with an emphasis on human skin DCs...
- Integrating experimental (in vitro and in vivo) neurotoxicity studies of low-dose thimerosal relevant to vaccines
Jose G Dorea
Faculty of Health Sciences, Universidade de Brasilia, CP 04322, 70919 970, Brasilia, DF, Brazil
Neurochem Res 36:927-38. 2011
..pregnant mothers, newborns and young children who must receive repeated doses of Thimerosal-containing vaccines (TCVs)...
- Mucosal vaccines: recent progress in understanding the natural barriers
Centre for Neuroscience and Cell Biology and Faculty of Pharmacy, University of Coimbra, Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000 548, Coimbra, Portugal
Pharm Res 27:211-23. 2010
..The development of vaccines for mucosal application requires antigen delivery systems and immunopotentiators that efficiently facilitate the ..
- Production and proteomic characterization of pharmaceutical-grade Dermatophagoides pteronyssinus and Dermatophagoides farinae extracts for allergy vaccines
Recherche et Developpement, Stallergènes, Antony, France
Int Arch Allergy Immunol 140:295-305. 2006
..Hence large quantities of well-characterized HDM extracts are needed to prepare pharmaceutical-grade allergy vaccines. To this aim, the present study was undertaken to define optimal conditions for large-scale cultures.
- Formulation of vaccines containing CpG oligonucleotides and alum
Joan A Aebig
Malaria Vaccine Development Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 5640 Fishers Lane, Rockville, MD, 20852 USA
J Immunol Methods 323:139-46. 2007
CpG oligodeoxynucleotides are potent immunostimulants. For parenterally delivered alum-based vaccines, the immunostimulatory effect of CpG depends on the association of the CpG and antigen to the alum...
- Immunization without needles
Department of Chemical Engineering, University of California, Santa Barbara, California 93106, USA
Nat Rev Immunol 5:905-16. 2005
..This article focuses on contemporary developments in needle-free methods of immunization, such as liquid-jet injectors, topical application to the skin, oral pills and nasal sprays...
- Targeting human dendritic cell subsets for improved vaccines
Baylor Institute for Immunology Research, Baylor Research Institute, 3434 Live Oak, Dallas, TX 75204, USA
Semin Immunol 23:21-7. 2011
..These progresses in our understanding of DC biology provide a new framework for improving human health. In this review, we discuss human DC subsets in the context of their medical applications, with a particular focus on DC targeting...
- Substance abuse vaccines
Frank M Orson
Veterans Affairs Medical Center, Houston, TX 77030, USA
Ann N Y Acad Sci 1141:257-69. 2008
..Although several potential mechanisms for the effects of antidrug vaccines have been suggested, the most straightforward and intuitive mechanism involves binding of the drug by antibodies ..
- Particulate vaccines: on the quest for optimal delivery and immune response
Marie Luce De Temmerman
Laboratory of General Biochemistry and Physical Pharmacy, Faculty of Pharmaceutical Sciences, Ghent University, Harelbekestraat 72, B 9000 Ghent, Belgium
Drug Discov Today 16:569-82. 2011
Subunit vaccines offer a safer alternative to traditional organism-based vaccines, but their immunogenicity is impaired. This hurdle might be overcome by the use of micro- and nanodelivery systems carrying the antigen(s)...
- Epitope identification and discovery using phage display libraries: applications in vaccine development and diagnostics
Lin Fa Wang
CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong 3220, Victoria, Australia
Curr Drug Targets 5:1-15. 2004
..Instead, this review aims to focus on specific applications related to the discovery and identification of epitopes which have potential as vaccine candidates or can be used in disease diagnosis...
- Vaccines and the future of human immunology
Ronald N Germain
Lymphocyte Biology Section and Program in Systems Immunology and Infectious Disease Modeling, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1892, USA
Immunity 33:441-50. 2010
..a collection of detailed reviews summarizes needs, opportunities, and roadblocks to the development of new vaccines, all in the context of our current knowledge and understanding of key aspects of immune function and microbial ..
- CD8+ T cell priming by dendritic cell vaccines requires antigen transfer to endogenous antigen presenting cells
Alice W Yewdall
Cancer Institute, New York University School of Medicine, New York, New York, United States of America
PLoS ONE 5:e11144. 2010
..To overcome this problem, autologous DCs are generated ex vivo, loaded with tumor antigens, and activated in this non-suppressive environment before administration to patients. However, DC-based vaccines rarely induce tumor regression.
- Improving the performance of enteric vaccines in the developing world
Andrew C Serazin
The Global Health Program, The Bill and Melinda Gates Foundation, Seattle, WA, USA
Nat Immunol 11:769-73. 2010
b>Vaccines against important enteric pathogens such as rotavirus and poliovirus have shown lower efficacy in some populations...
- Mucosal adjuvants and anti-infection and anti-immunopathology vaccines based on cholera toxin, cholera toxin B subunit and CpG DNA
Department of Medical Microbiology and Immunology and Göteborg University Vaccine Research Institute GUVAX, Goteborg University, P O Box 435, SE 40530 Goteborg, Sweden
Immunol Lett 97:181-8. 2005
..The development of mucosal vaccines, whether for prevention of infectious diseases or for oral tolerance immunotherapy, requires efficient antigen ..
- Anti-tick vaccines
CSIRO Livestock Industries, Queensland Bioscience Precinct, 306 Carmody Road, St Lucia, Queensland 4067, Australia
Parasitology 129:S367-87. 2004
..The existence of two commercial vaccines has allowed a number of field studies showing that the existing products can make an important contribution to an ..
- Controlling endemic cholera with oral vaccines
Ira M Longini
Vaccine and Infectious Disease Institute, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
PLoS Med 4:e336. 2007
..Internationally licensed, killed whole-cell based oral cholera vaccines (OCVs) have been available for over a decade, but have not been used for the control of cholera...
- New horizons in adjuvants for vaccine development
Steven G Reed
Infectious Disease Research Institute, 1124 Columbia St Suite 400, Seattle, WA 98104, USA
Trends Immunol 30:23-32. 2009
Over the last decade, there has been a flurry of research on adjuvants for vaccines, and several novel adjuvants are now in licensed products or in late stage clinical development...
- Random-peptide libraries and antigen-fragment libraries for epitope mapping and the development of vaccines and diagnostics
M B Irving
Department of Molecular Biology and Biochemistry, Simon Fraser University, BC V5A 1S6, Burnaby, Canada
Curr Opin Chem Biol 5:314-24. 2001
..These may prove useful for diagnosis and, possibly, in determining disease etiology...
- Aluminum salts in vaccines--US perspective
Norman W Baylor
Food and Drug Administration, Center for Biologics Evaluation and Research, Office of Vaccines Research and Review, Bethesda, MD, USA
Vaccine 20:S18-23. 2002
..in the form of aluminum hydroxide, aluminum phosphate or alum has been commonly used as an adjuvant in many vaccines licensed by the US Food and Drug Administration. Chapter 21 of the US Code of Federal Regulations [610...
- Alum interaction with dendritic cell membrane lipids is essential for its adjuvanticity
Tracy L Flach
Immunology Research Group, Department of Microbiology and Infectious Diseases, and Snyder Institute, University of Calgary, Calgary, Alberta, Canada
Nat Med 17:479-87. 2011
..This study therefore suggests an unexpected mechanism for how this crystalline structure interacts with the immune system and how the DC plasma membrane may behave as a general sensor for solid structures...
- Clinical development of plant-produced recombinant pharmaceuticals: vaccines, antibodies and beyond
Fraunhofer USA Center for Molecular Biotechnology, Newark, DE, USA
Hum Vaccin 7:313-21. 2011
..This builds on two decades of research, starting with transgenic approaches to develop oral vaccines in which antigens or therapeutics can be delivered in processed plant biomass, and progressing to transient ..
- Designing the next generation of vaccines for global public health
Novartis Vaccines and Diagnostics, Siena, Italy
OMICS 15:545-66. 2011
..emergence of multidrug resistant bacteria; (3) the need for improving the safety of the more traditional licensed vaccines; and finally, (4) the great promise for innovative vaccine design and research with convergence of omics sciences,..
- Aluminium compounds for use in vaccines
Erik B Lindblad
Adjuvant Department, Brenntag Biosector, DK 3600 Frederikssund, Denmark
Immunol Cell Biol 82:497-505. 2004
Aluminium adjuvants are the most widely used adjuvants in both human and veterinary vaccines. These adjuvants have been used in practical vaccination for more than 60 years and are generally recognized as safe and as stimulators of Th2 ..
- A novel M cell-specific carbohydrate-targeted mucosal vaccine effectively induces antigen-specific immune responses
Division of Mucosal Immunology, The Institute of Medical Science, The University of Tokyo, Tokyo 108 8639, Japan
J Exp Med 204:2789-96. 2007
..The use of NKM 16-2-4 to target vaccine antigens to the M cell-specific carbohydrate moiety is a new strategy for developing highly effective mucosal vaccines.
- Smallpox vaccines: targets of protective immunity
Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 3210, USA
Immunol Rev 239:8-26. 2011
..with the present susceptibility of unimmunized populations have spurred the development of new-generation vaccines that are safer than the original and can be produced by modern methods...
- Vaccine adjuvants: current challenges and future approaches
Jennifer H Wilson-Welder
Department of Veterinary Microbiology and Preventive Medicine, Iowa State University, Ames, Iowa 50011, USA
J Pharm Sci 98:1278-316. 2009
..A comprehensive discussion is presented of current vaccine adjuvants, their effects on the induction of immune responses, and vaccine adjuvants that have shown promise in recent literature...
- Cationic liposomes formulated with synthetic mycobacterial cordfactor (CAF01): a versatile adjuvant for vaccines with different immunological requirements
Else Marie Agger
Adjuvant Research, Department of Infectious Disease Immunology, Statens Serum Institut, Copenhagen, Denmark
PLoS ONE 3:e3116. 2008
It is now emerging that for vaccines against a range of diseases including influenza, malaria and HIV, the induction of a humoral response is insufficient and a substantial complementary cell-mediated immune response is necessary for ..
- Chitosan solution enhances both humoral and cell-mediated immune responses to subcutaneous vaccination
David A Zaharoff
Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, United States
Vaccine 25:2085-94. 2007
The development of safe, novel adjuvants is necessary to maximize the efficacy of new and/or available vaccines. Chitosan is a non-toxic, biocompatible, biodegradable, natural polysaccharide derived from the exoskeletons of crustaceans ..
- Saponin-adjuvanted particulate vaccines for clinical use
Caroline D Skene
Centre for Animal Biotechnology, University of Melbourne, Melbourne, VIC 3010, Australia
Methods 40:53-9. 2006
..These particulate vaccines retain the adjuvant activity of the saponin component but without toxicity...
- Rice-based mucosal vaccine as a global strategy for cold-chain- and needle-free vaccination
Division of Mucosal Immunology, Department of Microbiology and Immunology, The Institute of Medical Science, University of Tokyo, Tokyo 108 8639, Japan
Proc Natl Acad Sci U S A 104:10986-91. 2007
..Because they require neither refrigeration (cold-chain management) nor a needle, these rice-based mucosal vaccines offer a highly practical and cost-effective strategy for orally vaccinating large populations against mucosal ..
- Identification and characterization of a full-length cDNA encoding paramyosin of Trichinella spiralis
Department of Parasitology, School of Basic Medical Sciences, Capital Medical University, 10 Xitoutiao, You An Men, Beijing 100069, PR China
Biochem Biophys Res Commun 365:528-33. 2008
..These studies showed that rTs-Pmy induced protective immunity in mice and could be considered as a potential vaccine candidate for trichinellosis...
- Vaccines: from empirical development to rational design
Department of Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research, Braunschweig, Germany
PLoS Pathog 8:e1003001. 2012
..Furthermore, most currently available vaccines were empirically designed...
- Systems vaccinology: learning to compute the behavior of vaccine induced immunity
Helder I Nakaya
Emory Vaccine Center, Yerkes National Primate Research Center, Atlanta, GA, USA
Wiley Interdiscip Rev Syst Biol Med 4:193-205. 2012
..systems biology is being applied to vaccinology, with the goal of: (1) understanding the mechanisms by which vaccines stimulate protective immunity, and (2) predicting the immunogenicity or efficacy of vaccines...
- Tick vaccines and the control of tick-borne pathogens
SaBio, Instituto de Investigación en Recursos Cinegéticos IREC CSIC UCLM JCCM Ciudad Real, Spain
Front Cell Infect Microbiol 3:30. 2013
..In this article, we review the tick-protective antigens that have been identified for the formulation of tick vaccines and the effect of these vaccines on the control of tick-borne pathogens.
- Developments in allergen-specific immunotherapy: from allergen extracts to allergy vaccines bypassing allergen-specific immunoglobulin E and T cell reactivity
Christian Doppler Laboratory for Allergy Research, Division of Immunopathology, Department of Pathophysiology, Center for Pathophysiology, Immunology and Infectiology, Immunology and Infectiology, Medical University of Vienna, Vienna, Austria
Clin Exp Allergy 40:385-97. 2010
..poor quality of natural allergen extracts, which are the active ingredients of all currently available allergy vaccines. Because of the progress made in the field of molecular allergen characterization, new allergy vaccines based on ..
- Helminthes could influence the outcome of vaccines against TB in the tropics
Armauer Hansen Research Institute, Addis Ababa, Ethiopia
Parasite Immunol 28:507-13. 2006
..This information would also be of great relevance in the design of vaccines against diseases of major public health importance, including malaria and HIV/AIDS.
- T cell responses induced by adenoviral vectored vaccines can be adjuvanted by fusion of antigen to the oligomerization domain of C4b-binding protein
Emily K Forbes
The Jenner Institute, University of Oxford, Oxford, United Kingdom
PLoS ONE 7:e44943. 2012
Viral vectored vaccines have been shown to induce both T cell and antibody responses in animals and humans...
- Cytokines: the future of intranasal vaccine adjuvants
Afton L Thompson
Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA
Clin Dev Immunol 2011:289597. 2011
Due to its potential as an effective, needle-free route of immunization for use with subunit vaccines, nasal immunization continues to be evaluated as a route of immunization in both research and clinical studies...
- Commonly used prophylactic vaccines as an alternative for synthetically produced TLR ligands to mature monocyte-derived dendritic cells
Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Blood 116:564-74. 2010
Currently dendritic cell (DC)-based vaccines are explored in clinical trials, predominantly in cancer patients...
- Chitosan-based delivery systems for mucosal vaccines
Archimedes Development Ltd, Albert Einstein Centre, Nottingham Science and Technology Park, University Boulevard, Nottingham, UK
Expert Opin Drug Deliv 9:1051-67. 2012
..Chitosan-based delivery systems are reviewed here as they address these issues and hence represent the most promising candidates for the delivery of mucosal vaccines.
- The biotechnology-value chain: development of Sm14 as a schistosomiasis vaccine
Fundacao Oswaldo Cruz, Laboratório de Esquistossomose Experimental, Av Brasil, 4365, Manguinhos, Rio de Janeiro, RJ, CEP 21 045 900, Brazil Institute FIOCRUZ, Brazil
Acta Trop 108:263-6. 2008
..With regard to schistosomiasis, more than 10 important antigens with strong potential as vaccines candidates emerged from the several 100 scientific projects supported by international donor agencies and ..
- Protective efficacy of bacterial membranes containing surface-exposed BM95 antigenic peptides for the control of cattle tick infestations
Instituto de Investigacion en Recursos Cinegeticos IREC CSIC UCLM JCCM, Ronda de Toledo s n, 13005 Ciudad Real, Spain
Vaccine 27:7244-8. 2009
..coli and suggests the possibility of using recombinant bacterial membrane fractions for vaccination against cattle tick infestations...
- Optimizing efficacy of mucosal vaccines
University of Strathclyde, Strathclyde Institute of Pharmacy and Biomedical Sciences SIPBS, Glasgow, Scotland, UK
Expert Rev Vaccines 11:1139-55. 2012
In general, there are only a few vaccines administered via mucosal routes, as the mucosal immune system presents numerous hurdles, including diversity in mucosal surface structure, complexity in immune cell interaction and limitations in ..
- During the 'decade of vaccines,' the lives of 6.4 million children valued at $231 billion could be saved
Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
Health Aff (Millwood) 30:1010-20. 2011
..In this article we explore the benefits of expanding the delivery of life-saving vaccines in seventy-two low- and middle-income countries, which we estimate would prevent the deaths of 6...
- Intradermal delivery of vaccines: potential benefits and current challenges
J K Hickling
Tandem Ltd, Cambridge, England
Bull World Health Organ 89:221-6. 2011
..This is known as dose-sparing and has been demonstrated in clinical trials with some, but not all, vaccines. Dose-sparing could be beneficial to immunization programmes by potentially reducing the costs of purchase, ..
- Effector and memory T-cell differentiation: implications for vaccine development
Susan M Kaech
Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Nat Rev Immunol 2:251-62. 2002
..Models of the pathways of effector and memory T-cell differentiation are discussed, and we highlight the implications of this new understanding for the optimization of vaccine strategies...
- Vaccines to combat the neglected tropical diseases
Jeffrey M Bethony
Microbiology, Immunology, and Tropical Medicine, George Washington University Medical Center, Washington, DC 20037, USA
Immunol Rev 239:237-70. 2011
..Despite their global public health importance, progress on developing vaccines for NTD pathogens has lagged because of some key technical hurdles and the fact that these infections occur ..
- Mucosal vaccines: the promise and the challenge
Marian R Neutra
GI Cell Biology Research Laboratory, Children s Hospital and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115, USA
Nat Rev Immunol 6:148-58. 2006
..induced by mucosal immunization through oral, nasal, rectal or vaginal routes, but the vast majority of vaccines in use today are administered by injection...
- A decade of vaccines: Integrating immunology and vaccinology for rational vaccine design
David A D'Argenio
Global Health Discovery, Global Health Program, Bill and Melinda Gates Foundation, PO Box 23350, Seattle, WA 98102, USA
Immunity 33:437-40. 2010
..New approaches will be needed, however, to develop highly effective vaccines to prevent tuberculosis, HIV-AIDS, and malaria and to eradicate polio...
- What the world's religions teach, applied to vaccines and immune globulins
John D Grabenstein
Merck Vaccines, 770 Sumneytown Pike, WP97 B364, West Point, PA 19426, USA
Vaccine 31:2011-23. 2013
..a temple not to be defiled' is contrasted with other teaching and quality-control requirements in manufacturing vaccines and immune globulins...
- Vaccines against diseases transmitted from animals to humans: a one health paradigm
Thomas P Monath
One Health Initiative Pro Bono Team, United States 1 Austria PaxVax Inc, United States Electronic address
Vaccine 31:5321-38. 2013
..Three frameworks for the use of vaccines in this context are described, and examples are provided of successes and failures...
- Effect of a nicotine vaccine on nicotine binding to β2*-nicotinic acetylcholine receptors in vivo in human tobacco smokers
Department of Psychiatry, Yale University, New Haven, Conneticut, USA
Am J Psychiatry 170:399-407. 2013
..This likely contributes to maintenance of smoking dependence and cessation difficulty. Developing nicotine vaccines could improve treatments...
- Molecular Pharming: future targets and aspirations
Molecular Immunology Unit, Research Centre for Infection and Immunity, St George s Hospital Medical School, London, UK
Hum Vaccin 7:375-82. 2011
..is in the prevention of infectious diseases, particular in underdeveloped countries where access to medicines and vaccines has historically been limited. This is why, at St...
- Self-report compared to electronic medical record across eight adult vaccines: do results vary by demographic factors?
S J Rolnick
HealthPartners Institute for Education and Research, P O Box 1524, Minneapolis, MN 55440 1524, USA
Vaccine 31:3928-35. 2013
..to comprehensively assess the validity of self-reported adult vaccination status for the eight most common adult vaccines we conducted a survey of vaccination receipt and compared it to the electronic medical record (EMR), which was ..
- Thimerosal exposure in early life and neuropsychological outcomes 7-10 years later
John P Barile
Department of Psychology, Georgia State University, USA
J Pediatr Psychol 37:106-18. 2012
The authors used a public use data set to investigate associations between the receipt of thimerosal-containing vaccines and immune globulins early in life and neuropsychological outcomes assessed at 7-10 years.
- Immune effector mechanisms against schistosomiasis: looking for a chink in the parasite's armour
R Alan Wilson
Department of Biology, University of York, PO Box 373, York YO10 5YW, UK
Trends Parasitol 25:423-31. 2009
..In addition, ways need to be found of keeping the immune system on permanent alert, either to achieve adequate inhibition of protein function in adults, or because a trickle of incoming parasites does not amplify the secondary response...
- "IDEAL" vaccines for resource poor settings
Myron M Levine
Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Vaccine 29:D116-25. 2011
In developing countries, immunization delivery would be more efficient, safer and economical if all vaccines could elicit long-term protection following needle-free administration of just a single dose and without need for a cold chain, ..
- Vaccine and Immunization Surveillance in Ontario (VISION) - using linked health administrative databases to monitor vaccine safety
Ottawa Hospital, Civic Campus, 1053 Carling Avenue, Administrative Services Building, Room 1009, Box 684, Ottawa, ON K1Y 4E9, Canada
Vaccine 30:6115-20. 2012
..conducted population based self-controlled case series analyses to evaluate the safety of recommended pediatric vaccines in the general population and in specific subgroups...
- High immunogenicity of nicotine vaccines obtained by intradermal delivery with safe adjuvants
Wellman Center for Photomedicine, Massachusetts General Hospital, Department of Dermatology, Harvard Medical School, Boston, MA 02114, United States
Vaccine 31:159-64. 2012
..for tobacco addiction may offer a safe, alternative treatment if the immunogenicity of the current nicotine vaccines can be improved...
- The next decade of vaccines: societal and scientific challenges
E Richard Moxon
University of Oxford Department of Paediatrics, John Radcliffe Hospital, Oxford, UK
Lancet 378:348-59. 2011
b>Vaccines against microbial diseases have improved the health of millions of people...
- Immunomodulators as adjuvants for vaccines and antimicrobial therapy
Erin F Nicholls
Center for Microbial Diseases and Immunity Research, University of British Columbia, Vancouver, British Columbia, Canada
Ann N Y Acad Sci 1213:46-61. 2010
..The effectiveness of many vaccines currently in use is due in part to adjuvants, molecules that have little immunogenicity by themselves but which ..