biological products

Summary

Summary: Complex pharmaceutical substances, preparations, or agents of organic origin, usually obtained by biological methods or assay, that depend for their action on the processes affecting immunity. They are used especially in diagnosis and treatment of disease (as vaccines or pollen extracts). Biological products are differentiated from BIOLOGICAL FACTORS in that the latter are compounds with biological or physiological activity made by living organisms. (From Webster's 3d ed)

Top Publications

  1. ncbi Natural products as a screening resource
    Alan L Harvey
    Strathclyde Institute for Drug Research, University of Strathclyde, 27 Taylor Street, Glasgow G4 0NR, UK
    Curr Opin Chem Biol 11:480-4. 2007
  2. ncbi Natural products as sources of new drugs over the last 25 years
    David J Newman
    Natural Products Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute Frederick, P O Box B, Frederick, MD 21702, USA
    J Nat Prod 70:461-77. 2007
  3. ncbi Drug discovery and natural products: end of an era or an endless frontier?
    Jesse W H Li
    Department of Chemistry, University of Alberta, Edmonton, Alberta T6G 2G2, Canada
    Science 325:161-5. 2009
  4. ncbi Marine natural products
    John W Blunt
    Department of Chemistry, University of Canterbury, Christchurch, New Zealand
    Nat Prod Rep 29:144-222. 2012
  5. ncbi Drug development from marine natural products
    Tadeusz F Molinski
    Department of Chemistry and Biochemistry and Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive, MC 0358, La Jolla, California 92093, USA
    Nat Rev Drug Discov 8:69-85. 2009
  6. ncbi Natural products in drug discovery
    Alan L Harvey
    Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 27 Taylor Street, Glasgow G4 0NR, UK
    Drug Discov Today 13:894-901. 2008
  7. ncbi Natural products as sources of new drugs over the period 1981-2002
    David J Newman
    Natural Products Branch and Pharmaceutical Resources Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, Maryland 20892, USA
    J Nat Prod 66:1022-37. 2003
  8. ncbi The odyssey of marine pharmaceuticals: a current pipeline perspective
    Alejandro M S Mayer
    Department of Pharmacology, Chicago College of Osteopathic Medicine, Midwestern University, 555 31st Street, Downers Grove, IL 60515, USA
    Trends Pharmacol Sci 31:255-65. 2010
  9. ncbi Big effects from small changes: possible ways to explore nature's chemical diversity
    Helge Björn Bode
    Universität Göttingen Institut für Organische Chemie Biomolekulare Chemie Tammannstrasse 2, 37077 Gottingen, Germany
    Chembiochem 3:619-27. 2002
  10. ncbi The evolving role of natural products in drug discovery
    Frank E Koehn
    Wyeth Research, 401 North Middletown Road, Pearl River, New York 10965, USA
    Nat Rev Drug Discov 4:206-20. 2005

Detail Information

Publications305 found, 100 shown here

  1. ncbi Natural products as a screening resource
    Alan L Harvey
    Strathclyde Institute for Drug Research, University of Strathclyde, 27 Taylor Street, Glasgow G4 0NR, UK
    Curr Opin Chem Biol 11:480-4. 2007
    ..A renaissance of drug discovery inspired by natural products can be predicted...
  2. ncbi Natural products as sources of new drugs over the last 25 years
    David J Newman
    Natural Products Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute Frederick, P O Box B, Frederick, MD 21702, USA
    J Nat Prod 70:461-77. 2007
    ....
  3. ncbi Drug discovery and natural products: end of an era or an endless frontier?
    Jesse W H Li
    Department of Chemistry, University of Alberta, Edmonton, Alberta T6G 2G2, Canada
    Science 325:161-5. 2009
    ..Advances in rapid genetic sequencing, coupled with manipulation of biosynthetic pathways, may provide a vast resource for the future discovery of pharmaceutical agents...
  4. ncbi Marine natural products
    John W Blunt
    Department of Chemistry, University of Canterbury, Christchurch, New Zealand
    Nat Prod Rep 29:144-222. 2012
    ..Biosynthetic studies, first syntheses, and syntheses that lead to the revision of structures or stereochemistries, have been included...
  5. ncbi Drug development from marine natural products
    Tadeusz F Molinski
    Department of Chemistry and Biochemistry and Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive, MC 0358, La Jolla, California 92093, USA
    Nat Rev Drug Discov 8:69-85. 2009
    ..Providing an outlook into the future, we also examine the advances that may further expand the promise of drugs from the sea...
  6. ncbi Natural products in drug discovery
    Alan L Harvey
    Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 27 Taylor Street, Glasgow G4 0NR, UK
    Drug Discov Today 13:894-901. 2008
    ..It is hoped that the more efficient and effective application of natural products will improve the drug discovery process...
  7. ncbi Natural products as sources of new drugs over the period 1981-2002
    David J Newman
    Natural Products Branch and Pharmaceutical Resources Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, Maryland 20892, USA
    J Nat Prod 66:1022-37. 2003
    ....
  8. ncbi The odyssey of marine pharmaceuticals: a current pipeline perspective
    Alejandro M S Mayer
    Department of Pharmacology, Chicago College of Osteopathic Medicine, Midwestern University, 555 31st Street, Downers Grove, IL 60515, USA
    Trends Pharmacol Sci 31:255-65. 2010
    ....
  9. ncbi Big effects from small changes: possible ways to explore nature's chemical diversity
    Helge Björn Bode
    Universität Göttingen Institut für Organische Chemie Biomolekulare Chemie Tammannstrasse 2, 37077 Gottingen, Germany
    Chembiochem 3:619-27. 2002
    ....
  10. ncbi The evolving role of natural products in drug discovery
    Frank E Koehn
    Wyeth Research, 401 North Middletown Road, Pearl River, New York 10965, USA
    Nat Rev Drug Discov 4:206-20. 2005
    ....
  11. ncbi Natural products to drugs: natural product derived compounds in clinical trials
    Mark S Butler
    MerLion Pharmaceuticals, 1 Science Park Road, The Capricorn 05 01, Singapore Science Park II, Singapore 117528
    Nat Prod Rep 22:162-95. 2005
    ..Natural product derived drugs launched in the United States of America, Europe and Japan since 1998 and new natural product templates discovered since 1990 are discussed...
  12. ncbi Marine natural products and related compounds in clinical and advanced preclinical trials
    David J Newman
    Natural Products Branch, Developmental Therapeutics Program, NCI Frederick, P O Box B, Frederick, Maryland 21702, USA
    J Nat Prod 67:1216-38. 2004
    ..A substantial number of other potential agents are following in their wake in preclinical trials in these and in other diseases...
  13. ncbi Marine natural products as anticancer drugs
    T Luke Simmons
    College of Pharmacy, Oregon State University, 15th and Jefferson Avenue, Corvallis, OR 97331, USA
    Mol Cancer Ther 4:333-42. 2005
    ..This review highlights several marine natural products and their synthetic derivatives that are currently undergoing clinical evaluation as anticancer drugs...
  14. pmc Drug discovery from natural sources
    Young Won Chin
    Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA
    AAPS J 8:E239-53. 2006
    ....
  15. ncbi Marine natural products
    John W Blunt
    Department of Chemistry, University of Canterbury, Christchurch, New Zealand
    Nat Prod Rep 27:165-237. 2010
    ..Biosynthetic studies, first syntheses, and syntheses that lead to the revision of structures or stereochemistries, have been included...
  16. ncbi Developing a new resource for drug discovery: marine actinomycete bacteria
    William Fenical
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA 92093 0204, USA
    Nat Chem Biol 2:666-73. 2006
  17. pmc Novel chemical space exploration via natural products
    Josefin Rosén
    Department of Medicinal Chemistry, Division of Pharmacognosy, BMC, Uppsala University, Uppsala, Sweden
    J Med Chem 52:1953-62. 2009
    ..The identification of leads from a NP starting point may prove a useful strategy for drug discovery in the search for novel leads with unique properties...
  18. ncbi Natural products to drugs: natural product-derived compounds in clinical trials
    Mark S Butler
    MerLion Pharmaceuticals, 1 Science Park Road, The Capricorn 05 01, Singapore Science Park II, Singapore 117528
    Nat Prod Rep 25:475-516. 2008
    ..Also discussed are natural product-derived drugs launched since 2005, new natural product templates and late-stage development candidates...
  19. pmc Follow the leader: the use of leader peptides to guide natural product biosynthesis
    Trent J Oman
    Department of Chemistry, Howard Hughes Medical Institute, and Institute for Genomic Biology, University of Illinois at Urbana Champaign, Urbana, Illinois, USA
    Nat Chem Biol 6:9-18. 2010
    ....
  20. ncbi Charting, navigating, and populating natural product chemical space for drug discovery
    Hugo Lachance
    Departmen of Chemical Biology, Max Planck Institute of Molecular Physiology, Otto Hahn Strasse 11, 44227 Dortmund, Germany
    J Med Chem 55:5989-6001. 2012
    ..There are “holes” in these data sets that can and should be identified and explored by chemistry and biology...
  21. ncbi Mechanism of action of natural products used in the treatment of diabetes mellitus
    Pranav Kumar Prabhakar
    Department of Biotechnology, Indian Institute of Technology Madras, Chennai, India
    Chin J Integr Med 17:563-74. 2011
    ....
  22. doi American College of Rheumatology 2008 recommendations for the use of nonbiologic and biologic disease-modifying antirheumatic drugs in rheumatoid arthritis
    Kenneth G Saag
    University of Alabama, Birmingham, AL, USA
    Arthritis Rheum 59:762-84. 2008
  23. ncbi Bio-mining the microbial treasures of the ocean: new natural products
    Johannes F Imhoff
    Kieler Wirkstoff Zentrum am Leibniz Institut für Meereswissenschaften IFM GEOMAR, Düsternbrooker Weg 20, 24105 Kiel, Germany
    Biotechnol Adv 29:468-82. 2011
    ..One of these activities is represented by the Kieler Wirkstoff-Zentrum KiWiZ, which was founded in 2005 in Kiel (Germany)...
  24. pmc Statistical research on marine natural products based on data obtained between 1985 and 2008
    Gu Ping Hu
    School of Chemistry and Chemical Engineering, Sun Yat Sen University, Xingang Xilu, Guangzhou, China
    Mar Drugs 9:514-25. 2011
    ..The distribution and the temporal trend of these classes (biological classes and chemical structure classes) were investigated. We hope this article provides a comprehensive perspective on the research of marine natural products...
  25. ncbi Genomics-inspired discovery of natural products
    Jaclyn M Winter
    Leibniz Institute for Natural Product Research and Infection Biology, HKI, Jena D 07745, Germany
    Curr Opin Chem Biol 15:22-31. 2011
    ..As more genome sequences are becoming available, we are noticing the emergence of underexplored or neglected organisms as alternative resources for new therapeutic agents...
  26. ncbi Diterpenes from gorgonian corals
    Fabrice Berrue
    Department of Chemistry, Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, Prince Edward Island, C1A 4P3, Canada
    Nat Prod Rep 26:681-710. 2009
    ..There have been developments improving our understanding of the biosynthetic origin of selected diterpenes, and these will also be discussed. This review describes 602 new compounds from 177 articles...
  27. ncbi Marine natural products
    John W Blunt
    Department of Chemistry, University of Canterbury, Christchurch, New Zealand
    Nat Prod Rep 26:170-244. 2009
    ....
  28. ncbi Natural products in anticancer therapy
    A B da Rocha
    Comprehensive Cancer Center, The Lutheran University of Brazil, Canoas, RS
    Curr Opin Pharmacol 1:364-9. 2001
    ..Other agents originating from marine sources are bryostatin-1, aplidine, dolastatin 10 and ET-743, which have recently entered phase I and II clinical trials...
  29. pmc Clustered patterns of species origins of nature-derived drugs and clues for future bioprospecting
    Feng Zhu
    Key Laboratory of Chemical Biology, Guangdong Province Graduate School at Shenzhen, Tsinghua University, Shenzhen, Guangdong 518055, People s Republic of China
    Proc Natl Acad Sci U S A 108:12943-8. 2011
    ..The potential impact of these technologies on drug productivity and on the distribution patterns of drug-productive families is yet to be revealed...
  30. ncbi A renaissance in marine pharmacology: from preclinical curiosity to clinical reality
    Keith B Glaser
    Cancer Research R47J AP9, Abbott Laboratories, Abbott Park, IL 60064 6121, USA
    Biochem Pharmacol 78:440-8. 2009
    ....
  31. ncbi Marine pharmacology in 2007-8: Marine compounds with antibacterial, anticoagulant, antifungal, anti-inflammatory, antimalarial, antiprotozoal, antituberculosis, and antiviral activities; affecting the immune and nervous system, and other miscellaneous mec
    Alejandro M S Mayer
    Department of Pharmacology, Chicago College of Osteopathic Medicine, Midwestern University, 555 31st Street, Downers Grove, IL 60515, USA
    Comp Biochem Physiol C Toxicol Pharmacol 153:191-222. 2011
    ....
  32. ncbi The impact of natural products upon modern drug discovery
    A Ganesan
    School of Chemistry, University of Southampton, Southampton, UK
    Curr Opin Chem Biol 12:306-17. 2008
    ..Interestingly, the natural product leads in the Lipinski and parallel universe had an identical success rate (50%) in delivering an oral drug...
  33. ncbi Genomic mining for Aspergillus natural products
    Jin Woo Bok
    Department of Plant Pathology, University of Wisconsin, Madison, 53706, USA
    Chem Biol 13:31-7. 2006
    ..nidulans. In this paper, we highlight that LaeA-based genome mining helps decipher the secondary metabolome of Aspergilli and provides an unparalleled view to assess secondary metabolism gene regulation...
  34. ncbi Chemistry. The renaissance of natural products as drug candidates
    Ian Paterson
    Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK
    Science 310:451-3. 2005
  35. pmc Marine drugs from sponge-microbe association--a review
    Tresa Remya A Thomas
    Biological Oceanography, National Institute of Oceanography, Dona Paula, Goa, Pin 403004, India
    Mar Drugs 8:1417-68. 2010
    ..The need to augment production of these compounds through tissue culture and mariculture has also been stressed. The reviewed database of these compounds is available at www.niobioinformatics.in/drug.php...
  36. ncbi Introducing the parvome: bioactive compounds in the microbial world
    Julian Davies
    Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada
    ACS Chem Biol 7:252-9. 2012
    ....
  37. pmc Natural products version 2.0: connecting genes to molecules
    Christopher T Walsh
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA
    J Am Chem Soc 132:2469-93. 2010
    ..We conclude by considering two questions: What would it take to find all natural product scaffolds? What kind of scientists will be studying natural products in the future?..
  38. ncbi Property distributions: differences between drugs, natural products, and molecules from combinatorial chemistry
    Miklos Feher
    SignalGene Inc, 335 Laird Road, Unit 2, Guelph, Ontario, N1G 4P7, Canada
    J Chem Inf Comput Sci 43:218-27. 2003
    ..It is suggested that by mimicking certain distribution properties of natural compounds, combinatorial products might be made that are substantially more diverse and have greater biological relevance...
  39. ncbi Natural products from true mangrove flora: source, chemistry and bioactivities
    Jun Wu
    Tropical Marine Biological Research Station in Hainan Key Laboratory of Marine Bio resourses Sustainable Utilization, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou, China
    Nat Prod Rep 25:955-81. 2008
    ..It includes 349 metabolites and 150 references. The molecular phylogeny and chemotaxonomy of true mangrove plants is discussed...
  40. pmc Mycolic acid-containing bacteria induce natural-product biosynthesis in Streptomyces species
    Hiroyasu Onaka
    Department of Biotechnology, Faculty of Engineering, Toyama Prefectural University, Toyama 939 0398, Japan
    Appl Environ Microbiol 77:400-6. 2011
    ..We used these results to develop a new coculture method, called the combined-culture method, which facilitates the screening of natural products...
  41. pmc Biosynthesis of polyketide synthase extender units
    Yolande A Chan
    Department of Bacteriology, University of Wisconsin Madison, Madison, WI 53706, USA
    Nat Prod Rep 26:90-114. 2009
    ..This review covers the biosynthesis of extender units that are utilized for the assembly of polyketides by polyketide synthases. The metabolic origins of each of the currently known polyketide synthase extender units are covered...
  42. ncbi Reversal of multidrug resitance by natural substances from plants
    J Molnar
    Institute of Medical Microbiology and Immunobiology, University of Szeged, H 6720 Szeged, Dóm tér 10 Hungary
    Curr Top Med Chem 10:1757-68. 2010
    ..The antiproliferative effects as well as the MDR reversal activity of the studied compounds, applied in combination with anticancer drugs, were also discussed...
  43. pmc Beneficial effects of marine algal compounds in cosmeceuticals
    Noel Vinay Thomas
    Marine Biochemistry Lab, Department of Chemistry, Pukyong National University, Busan 608 737, Korea
    Mar Drugs 11:146-64. 2013
    ..The proper development of marine algae compounds will be helpful in cosmeceutical product development and in the development of the cosmeceutical industry...
  44. pmc Engineering microbial factories for synthesis of value-added products
    Jing Du
    Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    J Ind Microbiol Biotechnol 38:873-90. 2011
    ..Related topics on lignocellulose degradation, sugar utilization, and microbial tolerance improvement will also be discussed...
  45. pmc Bioactivity and applications of sulphated polysaccharides from marine microalgae
    Maria Filomena de Jesus Raposo
    CBQF Centro de Biotecnologia e Química Fina, Escola Superior de Biotecnologia, Centro Regional do Porto da Universidade Católica Portuguesa, Rua Dr Antonio Bernardino de Almeida, 4200 072 Porto, Portugal
    Mar Drugs 11:233-52. 2013
    ..Therefore, the great potentials of sPS from marine microalgae to be used as nutraceuticals, therapeutic agents, cosmetics, or in other areas, such as engineering, are approached in this review...
  46. pmc Modern natural products drug discovery and its relevance to biodiversity conservation
    David G I Kingston
    Department of Chemistry, M C 0212, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, United States
    J Nat Prod 74:496-511. 2011
    ..Results from International Cooperative Biodiversity Groups (ICBGs) working in Madagascar, Panama, and Suriname are used as examples of what can be achieved when biodiversity conservation is linked to drug discovery...
  47. ncbi Hexane fraction from Laminaria japonica exerts anti-inflammatory effects on lipopolysaccharide-stimulated RAW 264.7 macrophages via inhibiting NF-kappaB pathway
    Ji Young Lee
    Department of Food Science and Nutrition, Pukyong National University, 599 1, Daeyeon dong, Nam Gu, Busan, 608 737, South Korea
    Eur J Nutr 52:409-21. 2013
    ..japonica extract was shown to exert various biological activities; however, its anti-inflammatory activity has not been reported. The aim of this study is to investigate the molecular mechanisms underlying its anti-inflammatory action...
  48. pmc Breaking the silence: protein stabilization uncovers silenced biosynthetic gene clusters in the fungus Aspergillus nidulans
    Jennifer Gerke
    Abteilung für Molekulare Mikrobiologie and Genetik, Institut für Mikrobiologie and Genetik, Georg August Universitat, Gottingen, Germany
    Appl Environ Microbiol 78:8234-44. 2012
    ..The csnE/CSN5 gene is highly conserved in fungi, and therefore, the deletion is a feasible approach for the identification of new SMs...
  49. ncbi Towards mild metal-catalyzed C-H bond activation
    Joanna Wencel-Delord
    Westfalische Wilhelms Universitat Munster, Organisch Chemisches Institut, Corrensstrasse 40, 48149 Munster, Germany
    Chem Soc Rev 40:4740-61. 2011
    ..In addition, we examine select examples in complex natural product synthesis to demonstrate the synthetic utility of mild C-H functionalization (84 references)...
  50. pmc Pulmonary surfactant coating of multi-walled carbon nanotubes (MWCNTs) influences their oxidative and pro-inflammatory potential in vitro
    Michael Gasser
    Adolphe Merkle Institute, University of Fribourg, Marly, Switzerland
    Part Fibre Toxicol 9:17. 2012
    ..The effect of MWCNTs surface charge was also investigated in terms of amino (-NH2) and carboxyl (-COOH) surface modifications...
  51. ncbi Natural products and traditional medicine: turning on a paradigm
    Geoffrey A Cordell
    Natural Products Inc, Evanston, Illinois 60203, United States
    J Nat Prod 75:514-25. 2012
    ....
  52. ncbi Discovery of a natural product inhibitor targeting protein neddylation by structure-based virtual screening
    Hai Jing Zhong
    Institute of Chinese Medical Sciences, University of Macau, Macao SAR, China
    Biochimie 94:2457-60. 2012
    ..We envisage that the identification and molecular docking analysis of this bioactive scaffold as an NAE inhibitor would provide the scientific community with useful information in order to generate more potent analogues...
  53. ncbi Scaffold diversity of natural products: inspiration for combinatorial library design
    Kristina Grabowski
    Institute of Organic Chemistry and Chemical Biology, ZAFES CMP, Goethe University, Siesmayerstrasse 70, Frankfurt a M, Germany
    Nat Prod Rep 25:892-904. 2008
    ..In particular, an application of the self-organizing map technique is presented for natural product-derived compound and library design...
  54. ncbi A genomic screening approach to the structure-guided identification of drug candidates from natural sources
    Andreas Hornung
    Combinature Biopharm AG, Robert Roessle Strasse 10, 13125 Berlin, Germany
    Chembiochem 8:757-66. 2007
    ..The described screening strategy allows rapid access to novel natural products with predetermined structural properties...
  55. pmc Inhibition of dengue virus infections in cell cultures and in AG129 mice by a small interfering RNA targeting a highly conserved sequence
    David A Stein
    Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, OR, USA
    J Virol 85:10154-66. 2011
    ..Overall, the data indicate that DC-3 siRNA represents a useful research reagent and has potential as a novel approach to therapeutic intervention against the genetically diverse dengue viruses...
  56. pmc Current issues with acetaminophen hepatotoxicity--a clinically relevant model to test the efficacy of natural products
    Hartmut Jaeschke
    Department of Pharmacology, Toxicology and Therapeutics University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA
    Life Sci 88:737-45. 2011
    ..This review should assist investigators in the optimal use of this model to test the efficacy of natural compounds and obtain reliable mechanistic information...
  57. ncbi Marine natural products of fungal origin
    Muhammad Saleem
    Pharmaceutical Research Center, PCSIR Labs Complex, 75280, Karachi, Pakistan
    Nat Prod Rep 24:1142-52. 2007
    ..However, the potential of marine fungi has only been investigated to a limited extent. This review article contains 103 marine-derived fungal metabolites and 77 references...
  58. ncbi Developing a drug-like natural product library
    Ronald J Quinn
    Eskitis Institute, Griffith University, Brisbane, Australia
    J Nat Prod 71:464-8. 2008
    ..The knowledge generated in creation of the library of structurally characterized pure natural products may provide opportunities to front-load lead-like property space in natural product drug discovery programs...
  59. pmc An aldol-based build/couple/pair strategy for the synthesis of medium- and large-sized rings: discovery of macrocyclic histone deacetylase inhibitors
    Lisa A Marcaurelle
    Chemical Biology Platform, Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, United States
    J Am Chem Soc 132:16962-76. 2010
    ..The development of stereo-structure/activity relationships was made possible by screening all 16 stereoisomers of the macrolactams produced through the aldol-based B/C/P strategy...
  60. pmc Highlights of marine invertebrate-derived biosynthetic products: their biomedical potential and possible production by microbial associants
    Ocky K Radjasa
    Department of Marine Science, Faculty of Fishery and Marine Science, Diponegoro University, Semarang 50275, Central Java, Indonesia
    Bioorg Med Chem 19:6658-74. 2011
    ..Also significant is the circumstance that there are some 14 sponge-derived compounds that are available to facilitate fundamental biological investigations...
  61. ncbi Biosimilar epoetins and other "follow-on" biologics: update on the European experiences
    Wolfgang Jelkmann
    Institute of Physiology, University of Luebeck, Ratzeburger Allee 160, Luebeck, Germany
    Am J Hematol 85:771-80. 2010
    ..Only on proof of quality, efficacy and safety, biosimilars are a viable option because of their lower costs...
  62. ncbi Current approaches to exploit actinomycetes as a source of novel natural products
    Olga Genilloud
    Fundación MEDINA, Centro de Excelencia en Investigación de Medicamentos Innovadores en Andalucía, Avda Conocimiento 3, Parque Tecnologico Ciencias de la Salud, 18100 Granada, Spain
    J Ind Microbiol Biotechnol 38:375-89. 2011
    ....
  63. ncbi Cancer multidrug resistance (MDR): a major impediment to effective chemotherapy
    Mohd Fahad Ullah
    Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, Aligarh, Uttar Pradesh, India
    Asian Pac J Cancer Prev 9:1-6. 2008
    ..Since many of these are essential components of the human diet, they are expected to possess fewer side effects and may possibly represent a new generation of MDR modulators...
  64. pmc Marine pharmacology in 2005-2006: antitumour and cytotoxic compounds
    Alejandro M S Mayer
    Department of Pharmacology, Chicago College of Osteopathic Medicine, Midwestern University, Downers Grove, IL 60515, USA
    Eur J Cancer 44:2357-87. 2008
    ..Finally, this 2005-2006 overview of the marine pharmacology literature highlights the fact that the discovery of novel marine antitumour agents continued at the same active pace as during 1998-2004...
  65. ncbi Utilization of biologic agents in rheumatoid arthritis in the United States: analysis of prescribing patterns in 16,752 newly diagnosed patients and patients new to biologic therapy
    Yusuf Yazici
    New York University School of Medicine, NY, USA
    Bull NYU Hosp Jt Dis 66:77-85. 2008
    ..However, the extent to which these agents are used in current clinical practice in the United States (U.S.) has not been systematically evaluated...
  66. ncbi Deep-sea natural products
    Danielle Skropeta
    School of Chemistry, University of Wollongong, Wollongong, Australia
    Nat Prod Rep 25:1131-66. 2008
    ..Relevant synthetic studies on the deep-sea natural products have also been included...
  67. ncbi A randomized, multicenter masked comparison trial of poractant alfa (Curosurf) versus beractant (Survanta) in the treatment of respiratory distress syndrome in preterm infants
    Rangasamy Ramanathan
    Department of Pediatrics, Division of Neonatal Medicine, Women s and Children s Hospital and Good Samaritan Hospital, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Am J Perinatol 21:109-19. 2004
    ..05) than either beractant or poractant alfa (100 mg/kg dosing) in infants < or =32 weeks gestation with RDS...
  68. pmc Recent advances in awakening silent biosynthetic gene clusters and linking orphan clusters to natural products in microorganisms
    Yi Ming Chiang
    Graduate Institute of Pharmaceutical Science, Chia Nan University of Pharmacy and Science, Tainan 71710, Taiwan, ROC
    Curr Opin Chem Biol 15:137-43. 2011
    ..This review will highlight some of the most recent strategies to activate silent biosynthetic gene clusters and to elucidate their corresponding products and pathways...
  69. ncbi Targeting COX-2 expression by natural compounds: a promising alternative strategy to synthetic COX-2 inhibitors for cancer chemoprevention and therapy
    Claudia Cerella
    Laboratoire de Biologie Moléculaire et Cellulaire du Cancer, Fondation de Recherche Cancer et Sang, Hopital Kirchberg, 9 rue Edward Steichen, L 2540 Luxembourg, Luxembourg
    Biochem Pharmacol 80:1801-15. 2010
    ..In this review, we will analyze how natural compounds may modulate the multistep regulation of COX-2 gene expression and discuss their potential as a new generation of COX-2 targeting agents alternative to the synthetic COX-2 inhibitors...
  70. ncbi PKS and NRPS release mechanisms
    Liangcheng Du
    Department of Chemistry, University of Nebraska Lincoln, NE 68588, USA
    Nat Prod Rep 27:255-78. 2010
    ..The emphasis is on the novel enzymology and mechanistic insights revealed by the biosynthetic studies of new natural products...
  71. pmc Potential anti-HIV agents from marine resources: an overview
    Thanh Sang Vo
    Marine Biochemistry Laboratory, Department of Chemistry, Pukyong National University, Busan, Korea
    Mar Drugs 8:2871-92. 2010
    ..This contribution presents an overview of anti-HIV therapeutics derived from marine resources and their potential application in HIV therapy...
  72. ncbi Diversifying microbial natural products for drug discovery
    V Knight
    Cetek Corporation, 260 Cedar Hill St, Marlborough, MA 01752, USA
    Appl Microbiol Biotechnol 62:446-58. 2003
    ..This review will focus on approaches for diversifying microbial natural product strains and extract libraries, while decreasing genetic and chemical redundancy...
  73. pmc Role of natural product diversity in chemical biology
    Jiyong Hong
    Department of Chemistry, Duke University, Durham, NC 27708, USA
    Curr Opin Chem Biol 15:350-4. 2011
    ....
  74. ncbi Marine natural products
    John W Blunt
    Department of Chemistry, University of Canterbury, Christchurch, New Zealand
    Nat Prod Rep 21:1-49. 2004
    ..Syntheses that lead to the revision of structures or stereochemistries have been included (114), including any first total syntheses of a marine natural product...
  75. ncbi Pharmacological significance of glycosylation in therapeutic proteins
    Huijuan Li
    GlycoFi, Inc, a wholly owned subsidiary of Merck and Co, Inc 21 Lafayette St, Suite 200, Lebanon, NH 03766, United States
    Curr Opin Biotechnol 20:678-84. 2009
    ....
  76. pmc The relevance of higher plants in lead compound discovery programs
    A Douglas Kinghorn
    Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, Ohio 43210, USA
    J Nat Prod 74:1539-55. 2011
    ..In this review, progress made in the senior author's laboratory in research work on naturally occurring sweeteners and other taste-modifying substances and on potential anticancer agents from tropical plants will be described...
  77. ncbi Red yeast rice for dyslipidemia in statin-intolerant patients: a randomized trial
    David J Becker
    Chestnut Hill Hospital, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Ann Intern Med 150:830-9, W147-9. 2009
    ..Red yeast rice is an herbal supplement that decreases low-density lipoprotein (LDL) cholesterol level...
  78. ncbi Marine natural products as targeted modulators of the transcription factor NF-kappaB
    Florence Folmer
    Marine Natural Products Laboratory, Chemistry Department, University of Aberdeen, Old Aberdeen, Scotland
    Biochem Pharmacol 75:603-17. 2008
    ..The chemical characteristics and molecular targets of marine NF-kappaB inhibitors discovered to date are presented and discussed in the context of marine chemical ecology...
  79. pmc siRNAs: potential therapeutic agents against hepatitis C virus
    Usman A Ashfaq
    Division of Molecular Medicine, National Centre of Excellence in Molecular Biology, University of the Punjab, Lahore, Pakistan
    Virol J 8:276. 2011
    ..In the present review, we focused that combination of siRNAs against virus and host genes will be a better option to treat HCV...
  80. ncbi Marine natural products
    D John Faulkner
    Scripps Institution of Oceanography, University of California at San Diego, La Jolla 92093 0212, USA
    Nat Prod Rep 19:1-48. 2002
    ..The review contains 869 structures and 592 references, of which 434 appeared between January and December 2000...
  81. pmc ChEBI: a database and ontology for chemical entities of biological interest
    Kirill Degtyarenko
    European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
    Nucleic Acids Res 36:D344-50. 2008
    ..ChEBI includes an ontological classification, whereby the relationships between molecular entities or classes of entities and their parents and/or children are specified. ChEBI is available online at http://www.ebi.ac.uk/chebi/..
  82. ncbi Strategies for the discovery of new natural products by genome mining
    Malek Zerikly
    Department of Chemistry, University of Warwick, Coventry, UK
    Chembiochem 10:625-33. 2009
    ..This information can be exploited in a variety of ways in the search for new bioactive natural products...
  83. ncbi Metabolic engineering for plant natural product biosynthesis in microbes
    Joseph A Chemler
    Department of Chemical and Biological Engineering, University at Buffalo, The State University of New York, Buffalo, NY 14260, USA
    Curr Opin Biotechnol 19:597-605. 2008
    ....
  84. ncbi Factors influencing the immunogenicity of therapeutic proteins
    Huub Schellekens
    Department of Innovation Studies, Central Laboratory Animal Institute, Utrecht University, PO Box 80 190, 3508 TD Utrecht, The Netherlands
    Nephrol Dial Transplant 20:vi3-9. 2005
    ..The possible role of micelle (polysorbate 80 plus epoetin-alpha) formation in the PRCA upsurge with Eprex is currently being investigated...
  85. ncbi Biohalogenation: nature's way to synthesize halogenated metabolites
    Claudia Wagner
    Institute for Pharmaceutical Biology, University of Bonn, Nussallee 6, D 53115 Bonn, Germany
    J Nat Prod 72:540-53. 2009
    ..This review aims to give a comprehensive overview on the current knowledge concerning biological halogenations...
  86. ncbi Fishing for drugs from nature: zebrafish as a technology platform for natural product discovery
    Alexander D Crawford
    Department of Pharmaceutical Sciences, Katholieke Universiteit Leuven, Leuven, Belgium
    Planta Med 74:624-32. 2008
    ..Here, we review recent natural product research using zebrafish and evaluate the potential of this vertebrate model as a discovery platform for the systematic identification of bioactive natural products...
  87. ncbi Marine compounds and their antiviral activities
    Jarred Yasuhara-Bell
    Department of Tropical Medicine, Medical Microbiology and Pharmacology, John A Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI 96822, USA
    Antiviral Res 86:231-40. 2010
    ....
  88. ncbi Marine natural products
    John W Blunt
    Department of Chemistry, University of Canterbury, Christchurch, New Zealand
    Nat Prod Rep 20:1-48. 2003
    ..Syntheses that confirm or revise structures or stereochemistries have been included (95), including any first total synthesis of a marine natural product...
  89. ncbi Biodiversity as a source of anticancer drugs
    G Tan
    Program for Collaborative Research in the Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, 833 South Wood St, Chicago, IL 60612, USA
    Curr Drug Targets 7:265-77. 2006
    ..Far from being mutually exclusive, biodiversity and genomics should be the driving force of drug discovery in the 21st century...
  90. ncbi Multi-targeted natural products evaluation based on biological activity prediction with PASS
    Alexey Lagunin
    Institute of Biomedical Chemistry of Russian Academy Medical Science, Moscow, Russia
    Curr Pharm Des 16:1703-17. 2010
    ....
  91. ncbi Biosimilars: pharmacovigilance and risk management
    Leyre Zuñiga
    Faculty of Pharmacy, Pharmaceutical Technology Department, University of the Basque Country, Vitoria Gasteiz, Spain
    Pharmacoepidemiol Drug Saf 19:661-9. 2010
    ..Biologicals should always be commercialized with a brand name or the INN plus the manufacturer's name...
  92. pmc Abatacept with methotrexate versus other biologic agents in treatment of patients with active rheumatoid arthritis despite methotrexate: a network meta-analysis
    Patricia Guyot
    Mapi Values the Netherlands, De Molen 84, 3995 AX Houten, The Netherlands
    Arthritis Res Ther 13:R204. 2011
    ..6) between abatacept and other biologic disease modifying anti-rheumatic drugs (DMARDs) in patients with rheumatoid arthritis (RA) who have inadequate response to methotrexate (MTX-IR)...
  93. ncbi Rapid biomimetic total synthesis of (±)-rossinone B
    Ziyang Zhang
    Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education and Beijing National Laboratory for Molecular Science BNLMS, College of Chemistry, Peking University, Beijing 100871, China
    Org Lett 12:5554-7. 2010
    ....
  94. pmc Evaluation of the human host range of bovine and porcine viruses that may contaminate bovine serum and porcine trypsin used in the manufacture of biological products
    Carol Marcus-Sekura
    Biotechnology Assessment Services Inc, 7413 Ottenbrook Terrace, Rockville, MD 20855, USA
    Biologicals 39:359-69. 2011
    Current U.S. requirements for testing cell substrates used in production of human biological products for contamination with bovine and porcine viruses are U.S...
  95. pmc Kinase inhibitors from marine sponges
    Danielle Skropeta
    School of Chemistry, University of Wollongong, Wollongong, NSW 2522, Australia
    Mar Drugs 9:2131-54. 2011
    ..These compounds, which belong to diverse structural classes, are reviewed herein, and ordered based upon the kinase that they inhibit. Relevant synthetic studies on the marine natural product kinase inhibitors have also been included...
  96. ncbi Didemnins, tamandarins and related natural products
    Jisun Lee
    University of Pennsylvania, Department of Chemistry, Philadelphia, Pennsylvania, United States
    Nat Prod Rep 29:404-24. 2012
    ..This review highlights the long-standing study of didemnins and its critical application towards the understanding of the molecular mechanism of action of tamandarins and their potential use as therapeutic agents...
  97. pmc Chasing the treasures of the sea - bacterial marine natural products
    Tobias A M Gulder
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, and the Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego, La Jolla, CA 92093, USA
    Curr Opin Microbiol 12:252-60. 2009
    ..The increasingly interdisciplinary field of marine natural product chemistry thus strongly impacts future developments in medicine, chemistry, and biology...
  98. ncbi Marine chemical ecology
    Valerie J Paul
    Smithsonian Marine Station at Fort Pierce, 701 Seaway Drive, Fort Pierce, FL 34949, USA
    Nat Prod Rep 25:662-95. 2008
    ..This review covers the recent marine chemical ecology literature for benthic cyanobacteria, macroalgae, sponges, octocorals, molluscs, other benthic invertebrates, fish and seabirds...
  99. ncbi Probiotic Enterococcus lactis IITRHR1 protects against acetaminophen-induced hepatotoxicity
    Sapna Sharma
    Herbal Research Section, Indian Institute of Toxicology Research CSIR, Lucknow, Uttar Pradesh, India
    Nutrition 28:173-81. 2012
    ..In the present study, the protective effect of probiotic Enterococcus lactis IITRHR1 was evaluated at different doses (10(7), 10(8), and 10(9) colony-forming units) against APAP-induced liver damage...
  100. ncbi Tolerability of red yeast rice (2,400 mg twice daily) versus pravastatin (20 mg twice daily) in patients with previous statin intolerance
    Steven C Halbert
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Am J Cardiol 105:198-204. 2010
    ..In conclusion, red yeast rice was tolerated as well as pravastatin and achieved a comparable reduction of low-density lipoprotein cholesterol in a population previously intolerant to statins...
  101. ncbi Efficient mining of myxobacterial metabolite profiles enabled by liquid chromatography-electrospray ionisation-time-of-flight mass spectrometry and compound-based principal component analysis
    Daniel Krug
    Institute for Pharmaceutical Biotechnology, Universitat des Saarlandes, Saarbrucken, Germany
    Anal Chim Acta 624:97-106. 2008
    ....

Research Grants62

  1. SUPPORT CONTRACT FOR THE NTP INTERAGENCY CENTER/VALIDATION OF ALT METHODS
    David Allen; Fiscal Year: 2009
    ..Biologics Testing Biological products (commonly referred to as biologics) include vaccines, blood and blood components, allergenics, somatic ..
  2. Mechanisms Regulating Hemangioendothelioma: A Plastic Surgeon's Challenge
    Gayle M Gordillo; Fiscal Year: 2013
    ..how nox-4 regulates the growth of endothelial cells that develop into tumors and to determine whether the biological products that result from nox-4 derived oxidants can be used as biomarkers...
  3. Novel Strategies for Brain Tumor Therapy
    Ian F Pollack; Fiscal Year: 2012
    ..Laboratory Core (C) provides banking of tissue and serum samples, maintenance of cell lines, preparation of biological products, and therapeutic monitoring essential for the clinical protocols in this program...
  4. Continuous Countercurrent Tangential Chromatography
    Oleg Shinkazh; Fiscal Year: 2011
    ..of using Continuous Countercurrent Tangential Chromatography (CCTC) for the purification of high value biological products, e.g...
  5. Hospital Medicine and Economics Centers for Education & Research for Therapeutics
    David O Meltzer; Fiscal Year: 2010
    DESCRIPTION (Provided by the Applicant): Hospitals are the site of intensive use of drugs, biological products, and devices, with a major impact on both the outcome and cost of care...
  6. Packaging Cell Lines for Lentiviral Vector Products
    KENNETH G CORNETTA; Fiscal Year: 2010
    ..Rimedion proposes to generate a series of lentiviral packaging cell lines that will allow manufacturing of lentiviral products suitable for FDA licensure specifications. ..
  7. Phase II Commercialization of Continuous Countercurrent Tangential Chromatography
    Oleg Shinkazh; Fiscal Year: 2013
    ..commercialize Continuous Countercurrent Tangential Chromatography (CCTC) for the purification of high value biological products, e.g., monoclonal antibodies for the treatment of cancer and arthritis...
  8. CERT Coordinating Center
    MARK CHRISTOPHER HORNBROOK; Fiscal Year: 2010
    ..research and providing education that will advance the optimal use of drugs, medical devices, and biological products;3) Develop the CERTs strategic plan and tactical priorities for the next 4-year funding cycle;and 4) ..
  9. Tissue-Based Cytokine Immunotherapy for Skin Cancer
    Mary A Lokuta; Fiscal Year: 2011
    ..qualified using a panel of tests recommended by the FDA for characterization of cell lines used to produce biological products. Successful completion of the research outlined in this Fast-Track proposal will generate critical pre-..
  10. Granulin specific monoclonal antibodies to investigate their expression and role
    Ginette Serrero; Fiscal Year: 2013
    ..Providing tools that can detect measure and elucidate the role of these important biological products may also be useful in revealing the potential to use them as therapeutic targets or surrogate markers for ..
  11. Bioprocessing of Plasma Therapeutic Proteins using Sequential Affinity Monolithic
    Yow Pin Lim; Fiscal Year: 2007
    ..The FDA through the Center of Biologics Evaluation (CDER) has long recognized that the development of biological products is becoming increasingly challenging...
  12. New deubiquitinating enzymes, poly-ubiquitin substrates and assays.
    KIRSTY LAPAN; Fiscal Year: 2009
    ..PUBLIC HEALTH RELEVANCE: SBIR research project is to support the design, development, and production of biological products and diagnostic laboratory analysis kits...
  13. NOVEL ASSAY FOR MEASUREMENT OF ENDOTOXIN
    CONSTANCE WILSON; Fiscal Year: 2000
    ..lysate (LAL) assay, is FDA approved for the detection of endotoxin in human and animal parenteral drugs, biological products, and medical devices...
  14. Development of a production method for scaling up lentiviral vector manufacture
    MADHUSUDAN PESHWA; Fiscal Year: 2006
    ..plasmids into suspension cells, which offer a number of advantages over adherent cells for manufacturing biological products. The goal is to generate an efficient, suspension cell-based method for lentivirus production that can be ..
  15. GENE MARKERS IN SCHIZOPHRENIA AND OTHER PSYCHOSES
    Miron Baron; Fiscal Year: 1991
    ..goals will include the identification and characterization of the defective gene(s) and the associated biological products, and the assessment of gene-environment interaction...
  16. TOTAL SYNTHESIS OF AZADIRACHTIN
    K Nicolaou; Fiscal Year: 2008
    ..The proposed work is expected to impact the general areas of pharmaceutical and agricultural research, and infectious diseases in particular, through discoveries in synthetic organic chemistry and chemical biology. ..
  17. SYNTHESIS OF ANTICANCER AGENTS
    K C Nicolaou; Fiscal Year: 2010
    ..abstract_text> ..
  18. TOTAL SYNTHESIS OF APOPTOLIDIN
    K Nicolaou; Fiscal Year: 2004
    ..The proposed work is expected to have significant impact in the area of cancer chemotherapy and should provide enabling technologies and tools for biology and medicine. ..
  19. TOTAL SYNTHESIS OF NATURAL PRODUCTS
    K Nicolaou; Fiscal Year: 2002
    ..3] sigmatropic rearrangement and a radical based ring closure to form the bicyclic skeleton. ..
  20. Enabling Technologies for Combinatorial Chemistry
    K Nicolaou; Fiscal Year: 2005
    ..abstract_text> ..
  21. Postmarketing Assessments of Pharmaceutical Risk
    Robert Califf; Fiscal Year: 2002
    ..The CERTs have the mission of conducting research and providing education that will advance the optimal use of drugs, medical devices, and biological products.
  22. Domoic Acid and Neonatal Microglia Activation
    Alejandro Mayer; Fiscal Year: 2004
    ..activated microglia cells and their mediators play in DOM-induced excitotoxic neuronal injury and thus contribute to potential novel approaches for the therapy of the neuropathology associated with Amnesic Shellfish Poisoning in humans ..
  23. ANTIFUNGALS FROM MARINE INVERTEBRATES--AIDS ADJUVANTS
    Tadeusz F Molinski; Fiscal Year: 2010
    ..Optimized leads identified from those libraries will be advanced to in vitro and in vivo trials. ..
  24. NOVEL PROBES FOR IMMUNOPHILIN MEDIATED CELL CONTROL
    TADEUSZ MOLINSKI; Fiscal Year: 2001
    ..5. To understand how modulation of the FKBP12/ryanodine receptor complex by bastadins influences cellular growth and differentiation using the BC3H1 cell line as model. ..
  25. Nanoscale-Natural Products Chemistry
    TADEUSZ MOLINSKI; Fiscal Year: 2009
    ....
  26. Natural Product Antitumor Inducers of Apoptosis
    TADEUSZ MOLINSKI; Fiscal Year: 2004
    ..abstract_text> ..
  27. Synthesis of Macrolides, Steroids, Cyclopentanoids, etc.
    BARRY TROST; Fiscal Year: 2009
    ..These new synthetic methods apply to many structural types beyond those illustrated and constitutes a significant to gain access to complex molecular targets more easily. ..
  28. STUDIES OF TUBULIN-INTERACTIVE ANTICANCER DRUGS
    David Kingston; Fiscal Year: 2008
    ..Such compounds are expected to show good tubulin polymerization and cytotoxic properties, and may thus become synthetically accessible anticancer agents. ..
  29. Symbiont Models for Natural Product Pathway Manipulation
    Eric W Schmidt; Fiscal Year: 2010
    ..This study will thus provide practical solutions to problems in drug discovery and development with marine natural products. ..
  30. Metabolome of non-replicating M. tuberculosis
    GUIDO PAULI; Fiscal Year: 2003
    ..abstract_text> ..
  31. Managing the Risks of Therapeutic Products
    Judith Kramer; Fiscal Year: 2003
    ..To achieve this mission, the CERTs conduct research and provide education about efforts to optimize the use of drugs, devices, and biological products.
  32. Design of New Treatment Agents for Drug Abuse
    HUW M DAVIES; Fiscal Year: 2010
    ..This will be achieved through a multidisciplinary research program combining organic synthesis, medicinal chemistry, pharmacology and behavioral physiology, exploring the efficacy of a new class of 5HT2A receptor antagonists. ..
  33. DESIGN AND SYNTHESIS OF NONPEPTIDE PROTEASE INHIBITORS
    Arun K Ghosh; Fiscal Year: 2010
    ..This research integrates organic synthesis, protein-ligand x-ray crystallography, molecular modeling and in-depth virus and cell-biological studies to design the next generation of HIV-1 protease inhibitors. ..
  34. Mitochondrial Dysfunction and Drug Hepatotoxicity
    HARTMUT W JAESCHKE; Fiscal Year: 2010
    ..This new insight into the signaling mechanism of AAP-induced cell death holds the promise of establishing novel therapeutic approaches for preventing AAP-induced liver failure and potentially other forms of drug toxicity in humans. ..
  35. Application of C-H Activation to Natural Product Synthesis
    HUW M DAVIES; Fiscal Year: 2010
    ....
  36. Synthesis and Mechanism of DNA Cross-linking of FR900482
    Robert Williams; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  37. 400 MHz NMR Spectrometer for CSU Chemistry Facility
    Robert Williams; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  38. MECHANISMS OF TRANSFORMATION OF HEMATOPOIETIC CELLS
    JAMES MC CUBREY; Fiscal Year: 2001
    ..An understanding of how these signal transduction and apoptotic pathways impinge upon one another will further our comprehension of the consequences of abnormal oncogene activation and tumor progression. ..
  39. SYNTHESIS OF THE TEDANOLIDES, CYTOTOXIC POLYPROPIONATES
    Michael Jung; Fiscal Year: 2003
    ....
  40. Neurotoxins from Marine Algae and Cyanobacteria
    WILLIAM GERWICK; Fiscal Year: 2004
    ..Through established collaborations with various industrial partners, and the NOVASCREEN(R) program, development of these neurotoxins as potential therapeutics will occur as appropriate. ..
  41. SYNTHESIS AND EVALUATION OF NOVEL COCAINE ANALOGS
    Huw Davies; Fiscal Year: 2002
    ..The proposed studies will ensure that a greater structural diversity is brought into the types of compounds that will be considered as potential medications for the treatment of cocaine addiction. ..
  42. LC/MDS TOF Spectrometer for Instrument Facility at CSU
    Robert Williams; Fiscal Year: 2006
    ..Finally, many of these measurements will be made in an open access environment. [unreadable] [unreadable]..
  43. Methylphenidate Analogs as Medications for Cocaine Abuse
    Huw Davies; Fiscal Year: 2006
    ..Initial studies will also be carried out to determine if useful PET radioligands can be made from any potent and selective analogs that are discovered during these studies. ..
  44. Ras/Raf & PI3K/Akt Induced Breast Cancer Drug Resistance
    JAMES MC CUBREY; Fiscal Year: 2007
    ..Throughthese studies,moreinformationwillbe availableto treatbreast andothercancerpatientswithcombinationsof drugs,whichinhibitsignaltransductionand anti-apoptoticpathwaysleadingtodrug resistance. ..
  45. US-Japan Seminar on Marine Bioorganic Chemistry
    WILLIAM GERWICK; Fiscal Year: 2003
    ..S. plus 15 participants and 4 observers from Japan together so they can engage in both formal and informal discussions on frontier issues in marine bioorganic and natural products chemistry. ..
  46. Novel Approaches to the Assessment of Oral Mucosal Immu*
    Theresa Whiteside; Fiscal Year: 2003
    ..A better understanding of oral immunity in normal and HIV-infected mucosa is important for the development of new antiviral therapies, including oral antiviral vaccines. ..
  47. DNA-Based Vaccines for Oral Carcnoma
    Theresa Whiteside; Fiscal Year: 2005
    ....
  48. Mechanisms of Neutrophil-induced Liver Toxicity
    Hartmut Jaeschke; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  49. DEVELOPMENT OF LIGAND ASSISTED ASYMMETRIC SYNTHESES
    Arun Ghosh; Fiscal Year: 2001
    ..Besides the broad range of scope and generality, this line of research will provide excellent opportunities to teach and train graduate and undergraduate students in the laboratory. ..
  50. PROSTATIC DUCTAL SYSTEM--CELL TO CELL INTERACTION
    Chung Lee; Fiscal Year: 2002
    ..We propose to use a dominant negative type II TGF-beta receptor (TbetaRII-DN) expression vector to render cells insensitive to TGF-beta. We also will study the prostate of TGF-beta1 knockout mice. ..
  51. College Attendance and Heavy Drinking in Young Adulthood
    Mallie Paschall; Fiscal Year: 2004
    ..Findings of this study will help to inform prevention strategies targeting college students and other young adults at high risk for alcohol-related problems. ..
  52. Prevention of UV-carcinogenesis by antioxidant
    Santosh Katiyar; Fiscal Year: 2004
    ..abstract_text> ..
  53. FOLATE AMINOBORONIC ACIDS AS TARGETED ANTI-CANCER AGENTS
    VENKATRAM MEREDDY; Fiscal Year: 2008
    ..These molecules could act as targeted molecules for folate receptor overexpressing cancer lines and may be useful for especially for the treatment of metastasized and relapsed cancers. [unreadable] [unreadable] [unreadable]..
  54. Fracture Characteristics of Dental Materials
    Luke Hanley; Fiscal Year: 2008
    ..abstract_text> ..
  55. Oxidative Coupling in Natural Product Synthesis
    Phil Baran; Fiscal Year: 2009
    ....
  56. NEW RHODIUM-CATALYZED ALLYLIC ALKYLATION REACTIONS
    P Evans; Fiscal Year: 2006
    ..The development of a temporary silicon-tethered (TST) rhodium-catalyzed [4+2+2] carbocyclization approach to the diterpene, epoxydictymene. ..
  57. BIOSYNTHESIS OF SOME MICROBIAL METABOLITES
    Ronald Parry; Fiscal Year: 2007
    ..Future investigations of sparsomycin will focus on cloning the sparsomycin resistance gene from S. sparsogenes to understand the mechanism of self-resistance in this organism and to gain access to the biosynthetic genes. ..
  58. Total Synthesis of Anti-Cancer Natural Products
    Phil S Baran; Fiscal Year: 2010
    ..New strategies and methods in chemistry and substantial contributions to medicine are anticipated through strategic collaborations with several leaders in the field of cancer biology. ..
  59. PR3-ANCA Subsets and Disease Phenotype
    Ulrich Specks; Fiscal Year: 2005
    ..This study will provide new insights into the potential pathogenic role of PR3-ANCA that are not obtainable in any other way, and will constitute the most definitive study of these antibodies to date. ..
  60. ROLE OF HYALURONAN IN INFLAMMATORY BOWEL DISEASE
    Scott Strong; Fiscal Year: 2005
    ..abstract_text> ..
  61. Approaches to Bioactive Aminoimidazole Natural Products
    CARL LOVELY; Fiscal Year: 2008
    ..abstract_text> ..