teratogens

Summary

Summary: An agent that causes the production of physical defects in the developing embryo.

Top Publications

  1. pmc Teratogenic effects of diatom metabolites on sea urchin Paracentrotus lividus embryos
    Giovanna Romano
    Stazione Zoologica Anton Dohrn, Villa comunale 80121 Napoli, Italy
    Mar Drugs 8:950-67. 2010
  2. ncbi Developmental exposure to valproate and ethanol alters locomotor activity and retino-tectal projection area in zebrafish embryos
    John Cowden
    Integrated Systems Toxicology Division United States Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Reprod Toxicol 33:165-73. 2012
  3. ncbi 2-Hydroxypropyl-beta-cyclodextrin (HP-beta-CD): a toxicology review
    Sarah Gould
    Safety Assessment, AstraZeneca UK Limited, Mereside, Alderley Park, Macclesfield, Cheshire SK10 4TG, United Kingdom
    Food Chem Toxicol 43:1451-9. 2005
  4. ncbi Valproic acid in pregnancy: how much are we endangering the embryo and fetus?
    Asher Ornoy
    Laboratory of Teratology, Hebrew University Hadassah Medical School and Israeli Ministry of Health, Jerusalem, Israel
    Reprod Toxicol 28:1-10. 2009
  5. ncbi Aryl hydrocarbon receptor 2 mediates 2,3,7,8-tetrachlorodibenzo-p-dioxin developmental toxicity in zebrafish
    Amy L Prasch
    Molecular and Environmental Toxicology Center, University of Wisconsin, Madison, Wisconsin 53726, USA
    Toxicol Sci 76:138-50. 2003
  6. ncbi Improvement of an in vitro stem cell assay for developmental toxicity: the use of molecular endpoints in the embryonic stem cell test
    Andrea Seiler
    National Center for Documentation and Evaluation of Alternative Methods to Animal Experiments ZEBET, Federal Institute for Risk Assessment BfR, Berlin 12277, Germany
    Reprod Toxicol 18:231-40. 2004
  7. ncbi Structure-function studies for the panacea, valproic acid
    Nicole Terbach
    Centre for Biomedical Sciences, School of Biological Sciences, Royal Holloway University of London, Egham, UK
    Biochem Soc Trans 37:1126-32. 2009
  8. ncbi The ECVAM international validation study on in vitro embryotoxicity tests: results of the definitive phase and evaluation of prediction models. European Centre for the Validation of Alternative Methods
    Elke Genschow
    Federal Institute for Health Protection of Consumers and Veterinary Medicine BgVV, Berlin, Germany
    Altern Lab Anim 30:151-76. 2002
  9. ncbi Fetal exposure to teratogens: evidence of genes involved in autism
    Diane Dufour-Rainfray
    UMR Inserm U930, CNRS ERL 3106, Universite Francois Rabelais de Tours, Tours, France
    Neurosci Biobehav Rev 35:1254-65. 2011
  10. pmc Ethanol exposure during neurogenesis induces persistent effects on neural maturation: evidence from an ex vivo model of fetal cerebral cortical neuroepithelial progenitor maturation
    Cynthia Camarillo
    Department of Neuroscience and Experimental Therapeutics, Texas A and M Health Science Center College of Medicine, College Station, TX 77843, USA
    Gene Expr 14:159-71. 2008

Detail Information

Publications305 found, 100 shown here

  1. pmc Teratogenic effects of diatom metabolites on sea urchin Paracentrotus lividus embryos
    Giovanna Romano
    Stazione Zoologica Anton Dohrn, Villa comunale 80121 Napoli, Italy
    Mar Drugs 8:950-67. 2010
    ..Using decadienal as a model PUA, we show that this aldehyde can be detected spectrophotometrically for up to 14 days in f/2 medium...
  2. ncbi Developmental exposure to valproate and ethanol alters locomotor activity and retino-tectal projection area in zebrafish embryos
    John Cowden
    Integrated Systems Toxicology Division United States Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Reprod Toxicol 33:165-73. 2012
    ..As both valproate and ethanol are known human developmental neurotoxicants, these results add to the growing body of evidence showing the potential utility of zebrafish in screening compounds for mammalian developmental neurotoxicity...
  3. ncbi 2-Hydroxypropyl-beta-cyclodextrin (HP-beta-CD): a toxicology review
    Sarah Gould
    Safety Assessment, AstraZeneca UK Limited, Mereside, Alderley Park, Macclesfield, Cheshire SK10 4TG, United Kingdom
    Food Chem Toxicol 43:1451-9. 2005
    ..HP-beta-CD has been shown to be well tolerated in humans, with the main adverse event being diarrhoea and there have been no adverse events on kidney function, documented to date...
  4. ncbi Valproic acid in pregnancy: how much are we endangering the embryo and fetus?
    Asher Ornoy
    Laboratory of Teratology, Hebrew University Hadassah Medical School and Israeli Ministry of Health, Jerusalem, Israel
    Reprod Toxicol 28:1-10. 2009
    ..Other possible explanations are: increased fetal oxidative stress induced by VPA, with the brain being more susceptible to oxidative stress in comparison to other fetal organs, or the folic acid inhibitory action of this drug...
  5. ncbi Aryl hydrocarbon receptor 2 mediates 2,3,7,8-tetrachlorodibenzo-p-dioxin developmental toxicity in zebrafish
    Amy L Prasch
    Molecular and Environmental Toxicology Center, University of Wisconsin, Madison, Wisconsin 53726, USA
    Toxicol Sci 76:138-50. 2003
    ..Most strikingly, zfahr2 morphants exposed to TCDD never developed edema. Taken together, these results demonstrate that zfAHR2 mediates several endpoints of TCDD developmental toxicity in zebrafish...
  6. ncbi Improvement of an in vitro stem cell assay for developmental toxicity: the use of molecular endpoints in the embryonic stem cell test
    Andrea Seiler
    National Center for Documentation and Evaluation of Alternative Methods to Animal Experiments ZEBET, Federal Institute for Risk Assessment BfR, Berlin 12277, Germany
    Reprod Toxicol 18:231-40. 2004
    ..Thus, the improved EST holds promise as a new predictive screen for risk assessment with respect to developmental toxicity using stem cell technology and technological advances in the field of gene expression analysis...
  7. ncbi Structure-function studies for the panacea, valproic acid
    Nicole Terbach
    Centre for Biomedical Sciences, School of Biological Sciences, Royal Holloway University of London, Egham, UK
    Biochem Soc Trans 37:1126-32. 2009
    ..This short review will describe potential therapeutic pathways targeted by VPA, and highlight studies showing structural constraints necessary for these effects...
  8. ncbi The ECVAM international validation study on in vitro embryotoxicity tests: results of the definitive phase and evaluation of prediction models. European Centre for the Validation of Alternative Methods
    Elke Genschow
    Federal Institute for Health Protection of Consumers and Veterinary Medicine BgVV, Berlin, Germany
    Altern Lab Anim 30:151-76. 2002
    ..And, very importantly, an excellent predictivity (100%, except for PM1 of the WEC test, with 79%, considered as good) was obtained with strong embryotoxic chemicals in each of the three in vitro tests...
  9. ncbi Fetal exposure to teratogens: evidence of genes involved in autism
    Diane Dufour-Rainfray
    UMR Inserm U930, CNRS ERL 3106, Universite Francois Rabelais de Tours, Tours, France
    Neurosci Biobehav Rev 35:1254-65. 2011
    ..It seems essential to focus research on genes expressed during early neurodevelopment which may be the target of mutations or affected by drugs such as those included in this review...
  10. pmc Ethanol exposure during neurogenesis induces persistent effects on neural maturation: evidence from an ex vivo model of fetal cerebral cortical neuroepithelial progenitor maturation
    Cynthia Camarillo
    Department of Neuroscience and Experimental Therapeutics, Texas A and M Health Science Center College of Medicine, College Station, TX 77843, USA
    Gene Expr 14:159-71. 2008
    ..These data help explain the increased incidence of cerebral cortical neuronal heterotopias associated with the fetal alcohol syndrome...
  11. ncbi Reproductive and developmental toxicity of natural and depleted uranium: a review
    J L Domingo
    Laboratory of Toxicology and Environmental Health, School of Medicine, Rovira i Virgili University, Reus 43201, Spain
    Reprod Toxicol 15:603-9. 2001
    ..Data on the toxic effects of depleted uranium on reproduction and development are also reviewed...
  12. ncbi Teratogenicity of sodium valproate
    Rachel Alsdorf
    Boston University School of Medicine, 715 Albany Street, L 320, Boston, MA 02118, USA
    Expert Opin Drug Saf 4:345-53. 2005
    ..These efforts hope to enhance our understanding of AEDs and their associated risks by addressing past study limitations...
  13. ncbi Ethanol- and acetaldehyde-mediated developmental toxicity in zebrafish
    Mark J Reimers
    Department of Environmental and Molecular Toxicology, Oregon State University, 1007 Agriculture and Life Sciences, Corvallis, OR 97331, USA
    Neurotoxicol Teratol 26:769-81. 2004
    ..These results demonstrate that the zebrafish model will provide an opportunity to further evaluate the mechanism of action of ethanol on vertebrate development...
  14. ncbi Further validation of FETAX: evaluation of the developmental toxicity of five known mammalian teratogens and non-teratogens
    J A Bantle
    Department of Zoology, Oklahoma State University, Stillwater 74078
    Drug Chem Toxicol 13:267-82. 1990
    ..Pseudoephedrine scored as having moderate teratogenic potential, but amaranth and aspartame had little or no teratogenic potential. Results support the use of FETAX for the screening of developmental toxicants...
  15. ncbi In vitro developmental toxicology assays: A review of the state of the science of rodent and zebrafish whole embryo culture and embryonic stem cell assays
    Karen Augustine-Rauch
    Discovery Toxicology, Bristol Myers Squibb, Hopewell, New Jersey, USA
    Birth Defects Res C Embryo Today 90:87-98. 2010
    ..An overview of the state of the science and future directions are described...
  16. ncbi Bendectin: review of the medical literature of a comprehensively studied human nonteratogen and the most prevalent tortogen-litigen
    R L Brent
    Jefferson Medical College, Alfred I duPont Institute, Wilmington, DE 19899, USA
    Reprod Toxicol 9:337-49. 1995
    ..These data were evaluated with regard to the reproductive risks of Bendectin providing a scientific framework for evaluating the views of the experts in the Bendectin litigation...
  17. ncbi The embryonic stem cell test for the early selection of pharmaceutical compounds
    Sonia Whitlow
    F Hoffmann La Roche Ltd, Pharma Research, Basel, Switzerland
    ALTEX 24:3-7. 2007
    ..The model correctly classified 81% of the substances. Further experiments are necessary to increase the database of the assay...
  18. ncbi Maternal exposure to caffeine and risk of congenital anomalies: a systematic review
    Marilyn L Browne
    Bureau of Environmental and Occupational Epidemiology, New York State Department of Health, Troy, USA
    Epidemiology 17:324-31. 2006
    ..These reviews were narrative rather than systematic. The objective of the current systematic review is to provide a critical appraisal of epidemiologic evidence...
  19. ncbi Molecular changes associated with teratogen-induced cyclopia
    Evyn J Loucks
    Children s Memorial Research Center Program in Developmental Biology, Chicago, Illinois, USA
    Birth Defects Res A Clin Mol Teratol 79:642-51. 2007
    Exposure of zebrafish embryos to a number of teratogens results in cyclopia, but little is known about the underlying molecular changes.
  20. ncbi Effects of oxidative stress on embryonic development
    Phyllis A Dennery
    Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Birth Defects Res C Embryo Today 81:155-62. 2007
    ..During particular periods in development, the embryo is more or less susceptible to oxidative stress, and teratogens, which can modify redox status, such as thalidomide, phenytoin, and ethanol, will disrupt fetal development...
  21. ncbi Teratogens as anti-cancer drugs
    Mikhail V Blagosklonny
    Cancer Center, Ordway Research Institute, Albany, New York 12208, USA
    Cell Cycle 4:1518-21. 2005
    Most anticancer drugs are teratogens, merely because they target vital cellular functions...
  22. ncbi Zebrafish embryos as models for embryotoxic and teratological effects of chemicals
    Lixin Yang
    Institute of Toxicology and Genetics, Forschungszentrum Karlsruhe in the Helmholtz Association, Karlsruhe Institute of Technology, PO Box 3640, Karlsruhe 76021, Germany
    Reprod Toxicol 28:245-53. 2009
    ....
  23. ncbi Are selective serotonin reuptake inhibitors cardiac teratogens? Echocardiographic screening of newborns with persistent heart murmur
    Paul Merlob
    Department of Neonatology, Rabin Medical Center, Petah Tikva
    Birth Defects Res A Clin Mol Teratol 85:837-41. 2009
    ..Our aim was to investigate the rate of nonsyndromic congenital heart defects in newborns exposed in utero to SSRIs compared with unexposed controls...
  24. ncbi Adverse effects of prenatal methimazole exposure
    E Di Gianantonio
    Servizio di Informazione Teratologica (SIT, Genetica Clinica ed Epidemiologica, University of Padua, 35128 Padua, Italy
    Teratology 64:262-6. 2001
    ..Until further data are available, thyrotoxicosis should be treated with propylthiouracil, as it is apparently safer for use during the fertile period...
  25. ncbi Vascular endothelial growth factor rescues 2,3,7,8-tetrachlorodibenzo-p-dioxin inhibition of coronary vasculogenesis
    Irena D Ivnitski-Steele
    College of Pharmacy, University of New Mexico, Albuquerque, New Mexico 87131, USA
    Birth Defects Res A Clin Mol Teratol 67:496-503. 2003
    ..In the current study, we assessed whether TCDD inhibits early events in coronary endothelial tube formation and outgrowth, and whether this inhibition occurs through a vascular endothelial growth factor (VEGF)-dependent mechanism...
  26. ncbi Induction of a heat shock response (HSP 72) in rat embryos exposed to selected chemical teratogens
    P E Mirkes
    Department of Pediatrics, University of Washington School of Medicine, Seattle 98195
    Teratology 49:135-42. 1994
    ..blot analysis and 2-D gel electrophoresis/autoradiography were used to determine whether selected chemical teratogens induced the synthesis and accumulation of HSP 72 in postimplantation rat embryos exposed in vitro...
  27. ncbi The role of multiple drug resistance proteins in fetal and/or placental protection against teratogen-induced orofacial clefting
    Lesli Ann Rawles
    Angel Charity for Children Wings for Genetic Research, Steele Children s Research Center, Department of Pediatrics, Section of Medical and Molecular Genetics, University of Arizona, Tucson, Arizona, USA
    Mol Reprod Dev 74:1483-9. 2007
    ..studies have shown a role for multiple drug resistance proteins in protecting the fetus from a limited number of teratogens. We have expanded the number of proteins and teratogens examined by comparing the influence of the mdr1a and ..
  28. ncbi New proposals for testing drugs with IKr-blocking activity to determine their teratogenic potential
    Miriam Karlsson
    Department of Pharmaceutical Biosciences, Division of Toxicology, S 751 24, Uppsala University, Uppsala, Sweden
    Curr Pharm Des 13:2979-88. 2007
    ..astemizole, propulsive drug cisapride, antidepressive drugs and macrolide antibiotics) are potential human teratogens. It is the contention of this paper that the existing repeat dose regimen used in teratology studies to fulfil ..
  29. ncbi Obstetric toxicology: teratogens
    Michael Levine
    Section of Medical Toxicology, Department of Emergency Medicine, University of Southern California, 1200 North State Street, Room 1011, Los Angeles, CA 90033, USA
    Emerg Med Clin North Am 30:977-90. 2012
    ..Many medications are safe for use during pregnancy, including several that are listed as potential teratogens based on the Food and Drug Administration's (FDA) pregnancy classification; but it is important that the ..
  30. ncbi Postmarketing surveillance for human teratogenicity: a model approach
    C D Chambers
    Department of Pediatrics, University of California, San Diego, CA 92103 8446, USA
    Teratology 64:252-61. 2001
    ..Thus, traditional epidemiological methods are not universally effective in identifying new teratogens. The purpose of this report is to outline a complementary approach that can be used in addition to other more ..
  31. ncbi Characterization of valproic acid-initiated homologous recombination
    Kevin Sha
    Department of Pharmacology and Toxicology, Queen s University, Kingston, Ontario, Canada
    Birth Defects Res B Dev Reprod Toxicol 89:124-32. 2010
    ..We have also shown that VPA exposure leads to both an increase in reactive oxygen species (ROS) production and increased frequency of homologous recombination (HR)...
  32. ncbi Molecular mechanisms of 2,3,7,8-tetrachlorodibenzo-p-dioxin cardiovascular embryotoxicity
    Heather M H Goldstone
    The Josephine Bay Paul Center for Comparative Molecular Biology and Evolution, Marine Biological Laboratory, Woods Hole, MA 02543, USA
    Drug Metab Rev 38:261-89. 2006
    ..Gene expression profiling is elucidating additional pathways by which TCDD might act. We review our understanding of the mechanism of TCDD embryotoxicity at morphological and molecular levels...
  33. ncbi Common increase of GATA-3 level in PC-12 cells by three teratogens causing autism spectrum disorders
    Ujjwal K Rout
    Division of Pediatric Surgery, Department of Surgery, and the Departments of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS 39216, USA
    Neurosci Res 64:162-9. 2009
    ..These teratogens may disturb the ontogeny of the brain by altering the expression pattern of genes that regulate the normal ..
  34. ncbi Teratogen update: evaluation of the reproductive and developmental risks of caffeine
    M S Christian
    Argus International and Argus Research Laboratories, Horsham, Pennsylvania 19044, USA
    Teratology 64:51-78. 2001
    ..Proven human teratogens have an identifiable syndrome...
  35. ncbi 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) inhibition of coronary development is preceded by a decrease in myocyte proliferation and an increase in cardiac apoptosis
    I Ivnitski
    College of Pharmacy, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131-5691, USA
    Teratology 64:201-12. 2001
    ....
  36. ncbi Comparing three novel endpoints for developmental osteotoxicity in the embryonic stem cell test
    Nicole I zur Nieden
    Institute of Maternal and Child Health, University of Calgary, Calgary, AB T2N4N1, Canada
    Toxicol Appl Pharmacol 247:91-7. 2010
    ..In vivo, teratogens most often affect the normal development of bones, causing growth retardation, limb defects or craniofacial ..
  37. ncbi Update on new developments in the study of human teratogens
    T H Shepard
    University of Washington, Department of Pediatrics, Seattle, Washington 98195 6320, USA
    Teratology 65:153-61. 2002
    ..The purpose of this annual article is to highlight and briefly review new and significant information on agents that may be teratogenic in pregnant women. Various sources of on-line and printed information are given...
  38. ncbi Environmental causes of human congenital malformations: the pediatrician's role in dealing with these complex clinical problems caused by a multiplicity of environmental and genetic factors
    Robert L Brent
    Thomas Jefferson University, Alfred I duPont Hospital for Children, Laboratory of Clinical and Environmental Teratology, Wilmington, Delaware 19899, USA
    Pediatrics 113:957-68. 2004
    ..Known teratogens may be presumptively implicated by the spectrum of malformations that they produce...
  39. ncbi Mercury and human genotoxicity: critical considerations and possible molecular mechanisms
    María Elena Crespo-López
    Laboratorio de Farmacología Molecular, Instituto de Ciencias Biologicas, Universidade Federal do Para UFPA, 66075 110 Belem PA, Brazil
    Pharmacol Res 60:212-20. 2009
    ..All data reviewed here contributed to a better knowledge of the widespread concern about the safety limits of mercury exposure...
  40. ncbi Disturbing endoderm signaling to anterior neural plate of vertebrates by the teratogen cadmium
    Estíbaliz L Fernandez
    Department of Pharmaceutical Biosciences, Division of Toxicology, Biomedical Center, Uppsala University, Box 594, S 75124 Uppsala, Sweden
    Reprod Toxicol 18:653-60. 2004
    ..It is proposed that cadmium-induced NTD is due to interference with head-inductive signals from the endoderm to the adjacent layers...
  41. ncbi Inclusion and exclusion criteria for malformations in newborn infants exposed to potential teratogens
    Lewis B Holmes
    Active Malformations Surveillance Program, Department of Newborn Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02114, USA
    Birth Defects Res A Clin Mol Teratol 91:807-12. 2011
    The surveillance of newborn infants exposed to potential teratogens often relies on the findings in routine physicians' examinations to identify malformations...
  42. ncbi Chemical genetics: adding to the developmental biology toolbox
    Jing Ruey J Yeh
    Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520, USA
    Dev Cell 5:11-9. 2003
    ..New uses for old teratogens as well as novel chemical modulators of development have begun to fill this void.
  43. ncbi Triadimefon causes branchial arch malformations in Xenopus laevis embryos
    Elena Papis
    Dipartimento di Biotecnologie e Scienze Molecolari, Universita dell Insubria, Varese, Italy
    Environ Sci Pollut Res Int 13:251-5. 2006
    ....
  44. ncbi Postulated pathogenic pathway in triazole fungicide induced dysmorphogenic effects
    Elena Menegola
    Department of Biology, University of Milan, Via Celoria 26, 20133 Milan, Italy
    Reprod Toxicol 22:186-95. 2006
    ..The possible pathogenic pathway in triazole-related teratogenesis is discussed on the basis of different experimental approaches...
  45. ncbi Unintended pregnancies and exposure to potential human teratogens
    Jung Yeol Han
    The Korean Motherisk Program, Department of Obstetrics and Gynecology, Samsung Cheil Hospital and Women s Health Care Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Birth Defects Res A Clin Mol Teratol 73:245-8. 2005
    ..We aimed to investigate the risk factors associated with unintended pregnancies as well as the association between unintended pregnancies and potential teratogenic exposures...
  46. pmc Valproic acid increases expression of methylenetetrahydrofolate reductase (MTHFR) and induces lower teratogenicity in MTHFR deficiency
    Marc Roy
    Department of Human Genetics, McGill University Health Centre, Montreal Children s Hospital, Montreal, Quebec, Canada
    J Cell Biochem 105:467-76. 2008
    ..These results underscore the importance of folate interconversion in VPA-induced teratogenicity, since VPA increases MTHFR expression and has lower teratogenic potential in MTHFR deficiency...
  47. ncbi Potential teratogenic effects of benomyl in rat embryos cultured in vitro
    Matthew J Hewitt
    University of Leeds, Gledhow Wing, St James s University Hospital, Department of Obstetrics and Gynaecology, Level 9, Leeds LS97TF, UK
    Reprod Toxicol 20:271-80. 2005
    ..This study provides evidence that benomyl is a potential developmental toxicant, affecting many parameters of differentiation, including optic development at levels below those that could be considered embryotoxic...
  48. ncbi Teratogen update: inorganic arsenic
    J M DeSesso
    Biomedical Research Institute, Mitretek Systems, McLean, Virginia 22102, USA
    Teratology 64:170-3. 2001
    ..These studies, which used predominantly injection exposures, coupled with the paucity of epidemiology data, resulted in the erroneous inference that inorganic arsenic should be considered a human teratogen...
  49. ncbi In vitro teratogenic potential of two antifungal triazoles: triadimefon and triadimenol
    E Menegola
    Department of Biology, University of Milan, Italy
    In Vitro Cell Dev Biol Anim 36:88-95. 2000
    ..After immunostaining, embryos exposed to 12.5-125 microM Triadimenol showed specific cranial nerve and ganglia abnormalities. The possible implication of neural crest cell alterations on triazole-related abnormalities is discussed...
  50. ncbi Embryopathic effects of thalidomide and its hydrolysis products in rabbit embryo culture: evidence for a prostaglandin H synthase (PHS)-dependent, reactive oxygen species (ROS)-mediated mechanism
    Crystal J J Lee
    Faculty of Pharmacy, University of Toronto, 144 College St, Toronto, ON, Canada
    FASEB J 25:2468-83. 2011
    ....
  51. ncbi Action of valproic acid on Xenopus laevis development: teratogenic effects on eyes
    R Pennati
    Department of Biology, University of Milano, Via Celoria 26, 20133 Milan, Italy
    Teratog Carcinog Mutagen 21:121-33. 2001
    ..Teratogenesis Carcinog. Mutagen. 21:121-133, 2001...
  52. ncbi Human teratogens: update 2010
    Lewis B Holmes
    Genetics Unit, Massachusetts General Hospital for Children, and Department of Pediatrics, Harvard Medical School, Boston, MA, USA
    Birth Defects Res A Clin Mol Teratol 91:1-7. 2011
    A wide variety of human teratogens have been identified. The characteristics of human teratogens can be used in the assessment of apparent "new" teratogens, when postulated...
  53. ncbi Application of frog embryo teratogenesis assay-Xenopus to ecological risk assessment
    Robert A Hoke
    DuPont, Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware 19714, USA
    Environ Toxicol Chem 24:2677-90. 2005
    ....
  54. ncbi Stage-specific malformations and phenotypic changes induced in embryos of amphibian (Xenopus tropicalis) by triphenyltin
    Jing Yuan
    Department of Environmental Science, Key Laboratory of Urbanization and Ecological Restoration, East China Normal University, Shanghai 200062, China
    Ecotoxicol Environ Saf 74:1960-6. 2011
    ..Our results suggested that TPT-induced teratogenicity was highly stage-specific. The sensitive window of fin defects indicated that TPT affected the formation rather than induction or expansion of fins...
  55. ncbi Findings on potential teratogens from a case-control study in Western Australia
    Martha M Werler
    Telethon Institute for Child Health Research, Subiaco, Western Australia, Australia
    Aust N Z J Obstet Gynaecol 43:443-7. 2003
    ..To examine, in Western Australian women, pregnancy use of drugs that have been found to be associated with birth defect risks in other studies...
  56. ncbi Teratogenic effects of ethanol exposure on zebrafish visual system development
    F J Arenzana
    Dpto de Biología Celular y Patología, Instituto de Neurociencias de Castilla y Leon, Universidad de Salamanca, E 37007 Salamanca, Spain
    Neurotoxicol Teratol 28:342-8. 2006
    ..The use of zebrafish EK strain is a suitable in vivo vertebrate model system for analyzing the teratogenic effect of ethanol during vertebrate visual system morphogenesis as it relates to both cyclopia and FAS...
  57. ncbi Teratogen update: antithyroid drugs-methimazole, carbimazole, and propylthiouracil
    Orna Diav-Citrin
    The Israeli Teratogen Information Service, Israeli Ministry of Health, Jerusalem, Israel
    Teratology 65:38-44. 2002
  58. ncbi Prenatal teratogens and the development of adult mental illness
    J B Watson
    Social Science Research Institute, Allan Hancock Foundation, University of Southern California, Los Angeles 90089 0375, USA
    Dev Psychopathol 11:457-66. 1999
    ..findings suggest that maternal influenza infection and severe maternal stress may operate (in different ways) as teratogens, disrupting the development of the fetal brain and increasing risk for developing schizophrenia or depression in ..
  59. pmc Teratogen-induced, dietary and genetic models of congenital diaphragmatic hernia share a common mechanism of pathogenesis
    Robin D Clugston
    Department of Physiology, University of Alberta, 513 HMRC, Edmonton, AB, Canada, T6G 2S2
    Am J Pathol 169:1541-9. 2006
    ..Importantly, these data show that very distinct models of CDH all share a common pathogenic mechanism and, together with supporting evidence from pathological specimens, highlight our proposed pathogenic model for CDH...
  60. ncbi Developmental and reproductive toxicity of inorganic arsenic: animal studies and human concerns
    M S Golub
    Reproductive and Cancer Hazard Assessment Section, Environmental Protection Agency, Sacramento, CA 95814, USA
    J Toxicol Environ Health B Crit Rev 1:199-241. 1998
    ....
  61. ncbi Actions of piperidine alkaloid teratogens at fetal nicotinic acetylcholine receptors
    Benedict T Green
    Poisonous Plant Research Laboratory, Agricultural Research Service, United States Department of Agriculture, 1150 E 1400 N, Logan, UT 84341, USA
    Neurotoxicol Teratol 32:383-90. 2010
    ..The teratogenic action of these compounds may be related to their ability to activate and subsequently desensitize nAChRs...
  62. ncbi Evaluation of the embryotoxic potency of compounds in a newly revised high throughput embryonic stem cell test
    Annelieke K Peters
    Johnson and Johnson Pharmaceutical Research and Development J and J PRD, Department of Mechanistic Toxicology, Beerse, B 2340 Belgium
    Toxicol Sci 105:342-50. 2008
    ..The 96-well based EST is a promising addition to the screening process of newly developed chemicals and pharmaceuticals...
  63. ncbi Zebrafish: a predictive model for assessing drug-induced toxicity
    Patricia McGrath
    Phylonix, 100 Inman Street, Cambridge, MA 02139, USA
    Drug Discov Today 13:394-401. 2008
    ..Adaptation of conventional instrumentation combined with new nanotechnology developments will continue to expand use of zebrafish for drug screening...
  64. ncbi A novel hypothesis for thalidomide-induced limb teratogenesis: redox misregulation of the NF-kappaB pathway
    Jason M Hansen
    Antioxid Redox Signal 6:1-14. 2004
    ..We hypothesize that species-selective alterations in redox microenvironment caused by free radical production from thalidomide results in attenuation of the NF-kappaB-mediated gene expression that is responsible for limb outgrowth...
  65. ncbi Use of murine embryonic stem cells in embryotoxicity assays: the embryonic stem cell test
    Andrea E M Seiler
    National Center for Documentation and Evaluation of Alternative Methods to Animal Experiments ZEBET, Federal Institute for Risk Assessment BfR, Berlin, Germany
    Methods Mol Biol 329:371-95. 2006
    ..The in vitro embryotoxicity test described in this chapter is rapid, simple, and sensitive and can be usefully employed as a component of the risk/hazard assessment process...
  66. ncbi Relative developmental toxicity of glycol ether alkoxy acid metabolites in the embryonic stem cell test as compared with the in vivo potency of their parent compounds
    Esther De Jong
    National Institute of Public Health and the Environment RIVM, 3720 BA Bilthoven, The Netherlands
    Toxicol Sci 110:117-24. 2009
    ..This study illustrates that the EST can be used to set priorities for developmental toxicity testing within classes of related compounds...
  67. pmc Benzene and naphthalene in air and breath as indicators of exposure to jet fuel
    P P Egeghy
    Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7431, USA
    Occup Environ Med 60:969-76. 2003
    ..To estimate exposures to benzene and naphthalene among military personnel working with jet fuel (JP-8) and to determine whether naphthalene might serve as a surrogate for JP-8 in studies of health effects...
  68. ncbi 2,3,7,8-Tetrachlorodibenzo-p-dioxin activation of the aryl hydrocarbon receptor/aryl hydrocarbon receptor nuclear translocator pathway causes developmental toxicity through a CYP1A-independent mechanism in zebrafish
    Sara A Carney
    Molecular and Environmental Toxicology Center, University of Wisconsin, 777 Highland Avenue, Madison, WI 53705, USA
    Mol Pharmacol 66:512-21. 2004
    ..This suggests an alternative model in which TCDD-activated AHR/ARNT disrupts the normal process of growth and development by altering programs of gene expression or function...
  69. ncbi Induction of cytochrome P450 1A is required for circulation failure and edema by 2,3,7,8-tetrachlorodibenzo-p-dioxin in zebrafish
    Hiroki Teraoka
    Department of Toxicology, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Japan
    Biochem Biophys Res Commun 304:223-8. 2003
    ..This is the first molecular evidence demonstrating an essential requirement for CYP1A induction in TCDD-evoked developmental toxicities in any vertebrate species...
  70. ncbi Prediction of in vivo embryotoxic effect levels with a combination of in vitro studies and PBPK modelling
    Miriam Verwei
    TNO Quality of Life, PO Box 360, 3700 AJ Zeist, The Netherlands
    Toxicol Lett 165:79-87. 2006
    ..It is concluded that a combination of in vitro and in silico techniques appears to be a promising alternative test method for risk assessment of embryotoxic compounds...
  71. ncbi Embryonic stem cell test remastered: comparison between the validated EST and the new molecular FACS-EST for assessing developmental toxicity in vitro
    Roland Buesen
    German Federal Institute for Risk Assessment BfR, Center for Alternative Methods to Animal Experiments ZEBET, Berlin, Germany
    Toxicol Sci 108:389-400. 2009
    ..Due to significant improvements, this new molecular method holds promise as a sensitive, more rapid and reproducible screen highly suited to predict developmental toxicity in vivo from in vitro data...
  72. pmc The embryonic stem cell test as tool to assess structure-dependent teratogenicity: the case of valproic acid
    Christian Riebeling
    German Federal Institute for Risk Assessment BfR, Center for Alternative Methods to Animal Experiments ZEBET, 12277 Berlin, Germany
    Toxicol Sci 120:360-70. 2011
    ..Both in vitro protocols enable to reliably determine differentiation of murine stem cells toward the cardiomyocyte lineage and to assess its chemical-mediated inhibition...
  73. ncbi Teratology in the 20th century: environmental causes of congenital malformations in humans and how they were established
    Harold Kalter
    Department of Pediatrics, College of Medicine, University of Cincinnati, OH, USA
    Neurotoxicol Teratol 25:131-282. 2003
  74. ncbi Unexpected common mechanistic pathways for embryotoxicity of warfarin and lovastatin
    Karlfried Groebe
    ProteoSys AG, Mainz, Germany
    Reprod Toxicol 30:121-30. 2010
    ..We discuss these findings observed in in vitro toxicity tests, in a context of clinical validation and evidence-based toxicology...
  75. ncbi Ercc6l, a gene of SNF2 family, may play a role in the teratogenic action of alcohol
    Yajun Xu
    Laboratory of Molecular Toxicology and Developmental Molecular Biology, Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing 100083, China
    Toxicol Lett 157:233-9. 2005
    ..The expressions in the other three organs were unaffected. From the results, we considered that Ercc6l might play a role in the teratogenic action of alcohol...
  76. ncbi Metabolic activation capacity by primary hepatocytes expands the applicability of the embryonic stem cell test as alternative to experimental animal testing
    Michael Hettwer
    Institute for Food Toxicology and Analytical Chemistry, University of Veterinary Medicine Hannover, Hannover, Germany
    Reprod Toxicol 30:113-20. 2010
    ....
  77. ncbi Selection of test chemicals for the ECVAM international validation study on in vitro embryotoxicity tests. European Centre for the Validation of Alternative Methods
    Nigel A Brown
    Department of Anatomy and Developmental Biology, St George s Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK
    Altern Lab Anim 30:177-98. 2002
    ....
  78. ncbi ReProGlo: a new stem cell-based reporter assay aimed to predict embryotoxic potential of drugs and chemicals
    Frederik Uibel
    Institute of Experimental and Clinical Pharmacology and Toxicology, Department of Toxicology, University of Tubingen, Tubingen, Germany
    Reprod Toxicol 30:103-12. 2010
    ..Cyclophosphamide was also active but only after metabolic activation by hepatocytes. The new test may help to predict embryotoxic potential of chemicals...
  79. ncbi Developmental toxicity induced during early stages of mammalian embryogenesis
    J C Rutledge
    Department of Laboratory Medicine, University of Washington School of Medicine, Seattle, USA
    Mutat Res 396:113-27. 1997
    ..Pre-gastrulation teratology is a new area of investigation with relevance both to reproductive toxicology and to mammalian developmental biology...
  80. ncbi Developmental toxicity of the angiotensin II type 1 receptor antagonists during human pregnancy: a report of 10 cases
    Raphael Serreau
    Department of Pediatric Pharmacology and Pharmacogenetics, Hopital Robert Debre, Paris, France
    BJOG 112:710-2. 2005
    ..Angiotensin II type 1 receptor antagonists (ARA). Interacted with the renin-angiotensin system, and the present study was undertaken to examine their fetal and neonatal toxicity when taken by the mother during pregnancy...
  81. ncbi Transcriptomics-based identification of developmental toxicants through their interference with cardiomyocyte differentiation of embryonic stem cells
    Dorien A M van Dartel
    Laboratory for Health Protection Research, National Institute for Public Health and the Environment RIVM, Bilthoven, The Netherlands
    Toxicol Appl Pharmacol 243:420-8. 2010
    ..Furthermore, this approach may improve the definition of the applicability domain and predictivity of the EST...
  82. ncbi The transcriptional signature of dioxin in human hepatoma HepG2 cells
    A Puga
    Center for Environmental Genetics and Department of Environmental Health, University of Cincinnati Medical Center, P O Box 670056, Cincinnati, OH 45267 0056, USA
    Biochem Pharmacol 60:1129-42. 2000
    ....
  83. ncbi Differential teratogenic effect of alcohol on embryonic development between C57BL/6 and DBA/2 mice: a new view
    Tetsuo Ogawa
    From the Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Alcohol Clin Exp Res 29:855-63. 2005
    ..Whether genetic factors or conditions of alcohol exposure influence the susceptibility to alcohol-related developmental impairment remains a question...
  84. ncbi p53 regulates cyclophosphamide teratogenesis by controlling caspases 3, 8, 9 activation and NF-kappaB DNA binding
    Olga Pekar
    Department of Cell and Developmental Biology, Sackler School of Medicine, Tel Aviv University, Ramat Aviv, Tel Aviv 69978, Israel
    Reproduction 134:379-88. 2007
    The tumor suppressor protein p53 regulates the sensitivity of embryos to such human teratogens as ionizing radiation, diabetes, and cytostatics. Yet, the molecular mechanisms whereby it fulfills this function remain undefined...
  85. ncbi Effects of epidermal growth factor receptor deficiency and 2,3,7,8-tetrachlorodibenzo-p-dioxin on fetal development in mice
    Hanna M Miettinen
    Laboratory of Toxicology, Department of Environmental Health, National Public Health Institute, P O Box 95, FIN 70701 Kuopio, Finland
    Toxicol Lett 150:285-91. 2004
    ..In conclusion, EGFR signaling is not required for TCDD-induced cleft palate or hydronephrosis but TCDD appears to counteract the effect of EGFR deficiency on eye opening...
  86. ncbi Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on murine heart development: alteration in fetal and postnatal cardiac growth, and postnatal cardiac chronotropy
    E A Thackaberry
    College of Pharmacy, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131, USA
    Toxicol Sci 88:242-9. 2005
    2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and related chemicals are potent cardiovascular teratogens in developing piscine and avian species. In the present study we investigated the effects of TCDD on murine cardiovascular development...
  87. ncbi TNF-alpha protects embryos exposed to developmental toxicants
    Arkady Torchinsky
    Department of Embryology and Teratology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Am J Reprod Immunol 49:159-68. 2003
    ..In order to clarify the role of TNF-alpha further, a comparative study was performed in TNF-alpha, knockout and TNF-alpha, positive mice, exposed to a reference teratogen, cyclophosphamide (CP)...
  88. ncbi Teratogenicity of recently introduced medications in human pregnancy
    W Y Lo
    Department of Medical Genetics, University of British Columbia, Vancouver, Canada
    Obstet Gynecol 100:465-73. 2002
    ..To determine how long it takes after a new drug is marketed to establish whether or not its use by pregnant women is likely to pose a substantial teratogenic risk...
  89. ncbi Alcohol teratogenesis: mechanisms of damage and strategies for intervention
    Charles R Goodlett
    Department of Psychology, Indiana University Purdue University at Indianapolis, 402 North Blackford Street, Indianapolis, Indiana 46202, USA
    Exp Biol Med (Maywood) 230:394-406. 2005
    ....
  90. ncbi Embryotoxic effects of CKD-602, a new camptothecin anticancer agent, in rats
    Moon Koo Chung
    Korea Institute of Toxicology, KRICT, Daejeon 305 600, Republic of Korea
    Reprod Toxicol 20:165-73. 2005
    ..e. at 80 microg/kg/d in rats. The no-observed-adverse-effect level (NOAEL) of CKD-602 for developmental toxicity was considered to be 20 microg/kg/d, however, the NOAEL for maternal toxicity was 5 microg/kg/d...
  91. ncbi Discriminative power of an assay for automated in vitro screening of teratogens
    Peter S Walmod
    Protein Laboratory, Institute for Molecular Pathology, Panum Institute, University of Copenhagen, Blegdamsvej 3C, Bld 6 2, 2200 Copenhagen N, Denmark
    Toxicol In Vitro 18:511-25. 2004
    ..0374), the strongest teratogens being the most potent...
  92. ncbi Convergent effects on cell signaling mechanisms mediate the actions of different neurobehavioral teratogens: alterations in cholinergic regulation of protein kinase C in chick and avian models
    Joseph Yanai
    The Ross Laboratory for Studies in Neural Birth Defects, Department of Anatomy, and Cell Biology, The Hebrew University Hadassah Medical School, Jerusalem, Israel
    Ann N Y Acad Sci 1025:595-601. 2004
    ..The avian models can provide rapid screening of neuroteratogens, exploration of common mechanisms of behavioral disruption, and the potential design of therapies to reverse neurobehavioral deficits...
  93. ncbi Immunoteratology: I. MHC involvement in the embryo response to teratogens in mice
    A Torchinsky
    Department of Embryology and Teratology, Sackler School of Medicine, Tel Aviv University, Israel
    Am J Reprod Immunol 34:288-98. 1995
    The present study was carried out to evaluate an involvement of MHC-associated maternal immunoreactivity in response to environmental teratogens.
  94. ncbi Understanding dioxin developmental toxicity using the zebrafish model
    Sara A Carney
    Molecular and Environmental Toxicology Center, University of Wisconsin, Madison, Wisconsin 53705 2222, USA
    Birth Defects Res A Clin Mol Teratol 76:7-18. 2006
    ....
  95. ncbi Activator protein-1 (AP-1) DNA binding activity is induced by hydroxyurea in organogenesis stage mouse embryos
    Jin Yan
    Department of Pharmacology and Therapeutics, McGill University, Montreal, QC, Canada
    Toxicol Sci 85:1013-23. 2005
    ..The induction of AP-1 DNA binding activity by hydroxyurea represents an early, sensitive marker of the embryonic response to insult...
  96. ncbi Toxicogenomic profile of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the murine fetal heart: modulation of cell cycle and extracellular matrix genes
    E A Thackaberry
    College of Pharmacy, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131, USA
    Toxicol Sci 88:231-41. 2005
    ..TCDD) and similar environmental contaminants have been demonstrated to be potent cardiovascular teratogens in developing piscine and avian species...
  97. ncbi Valproate: a simple chemical with so much to offer
    G M Peterson
    Unit for Medication Outcomes Research and Education, School of Pharmacy, University of Tasmania, Hobart, Australia
    J Clin Pharm Ther 30:417-21. 2005
  98. ncbi Heart malformation is an early response to TCDD in embryonic zebrafish
    Dagmara S Antkiewicz
    Molecular and Environmental Toxicology Center, University of Wisconsin, Madison, Wisconsin 53705, USA
    Toxicol Sci 84:368-77. 2005
    ..We conclude that the developing heart is an important target for TCDD in zebrafish...
  99. ncbi For dioxin-induced birth defects, mouse or human CYP1A2 in maternal liver protects whereas mouse CYP1A1 and CYP1B1 are inconsequential
    Nadine Dragin
    Department of Environmental Health and Center for Environmental Genetics, University of Cincinnati Medical Center, Cincinnati, Ohio 45267 0056, USA
    J Biol Chem 281:18591-600. 2006
    ..In contrast, neither CYP1A1 nor CYP1B1 appears to play a role in dioxin-mediated teratogenesis...
  100. ncbi Severe craniofacial malformations resulting from developmental exposure to dioxin
    Ronnie L Yeager
    Reprod Toxicol 22:811-2. 2006
  101. ncbi Embryo toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin to the wood duck (Aix sponsa)
    T P Augspurger
    U S Fish and Wildlife Service, 551 F Pylon Drive, Raleigh, NC 27606, USA
    Arch Environ Contam Toxicol 55:659-69. 2008
    ....

Research Grants64

  1. SPEAKER TRAVEL AND SCIENTIFIC SESSION SUPPORT FOR THE TERATOLOGY SOCIETY 50TH
    Christina Chambers; Fiscal Year: 2011
    ..Lewis B. Holmes will present Human Teratogens: The Year in Review, and Linda Birnbaum, Director of the NIEHS, will present a special lecture entitled ..
  2. microRNAs in Developmental Toxicology
    Mark E Hahn; Fiscal Year: 2010
    ..However, many xenobiotic chemicals are known to be developmental toxicants or teratogens in experimental animals and several human birth defects are associated with embryonic exposure to xenobiotics...
  3. Development of an Epigenetic Biomarker for Prediction of Fetal Alcohol Spectrum D
    AILEEN ESTELLE BALDWIN; Fiscal Year: 2013
    ..alcohol throughout pregnancy, particularly during the first trimester when the fetal brain is most vulnerable to teratogens, to predict those at risk for developing the neurobehavioral and developmental disabilities associated with FASD...
  4. Control of Multidrug Transport Activity in Embryos
    Amro M Hamdoun; Fiscal Year: 2011
    ..model, in order to characterize the role of these activity changes in protection of the embryo from potential teratogens encountered during assisted reproduction...
  5. Developmental Teratogenesis of Methylmercury in Hippocampal stem cells
    Maryann Obiorah; Fiscal Year: 2013
    ..During development, the brain is very sensitive to environmental chemicals (toxicants) which can act as teratogens, that is, substances that injure the brain in ways that are more related to when one is exposed than to the ..
  6. Characterization of craniofacial development in a zebrafish mutant lacking all cr
    TRACIE L FERREIRA; Fiscal Year: 2011
    ..These defects can be caused by environmental teratogens and/or genetic defects...
  7. Prevention of HPE in a mouse model susceptible to retinoic acid teratogenicity
    Anna Petryk; Fiscal Year: 2013
    ..pathogenesis of HPE, specifically how mutations with low penetrance can sensitize the embryos to environmental teratogens;2) improved understanding of the interactions between BMP and RA signaling;3) enhanced knowledge about the roles ..
  8. Dietary Cysteine:Conceptal Response to Oxidative Stress
    Craig Harris; Fiscal Year: 2002
    ..Several human teratogens are known to elicit oxidative stress, although relatively little is known about the mechanisms that regulate ..
  9. GENOTYPE AND PHENOTYPE OF BRAINSTEM INJURY IN AUTISM
    Patricia Rodier; Fiscal Year: 2002
    ..This suggests a unifying hypothesis regarding the multiple etiologies of autism: We propose that teratogens and genetic defects lead to similar developmental changes in the brain stem because mutations of early ..
  10. Craniofacial defects in ethanol-exposed zebrafish
    Sara Ahlgren; Fiscal Year: 2004
    ..The zebrafish is an excellent model for comparing teratogens, like alcohol, with genetic defects, to determine what candidate genes might be altered by environmental ..
  11. Scientific Conference on Moebius Syndrome
    VICKI MCCARRELL; Fiscal Year: 2006
    ..and epidemiologic databases for Moebius syndrome research; Methodologies to determine environmental factors/teratogens/genes which may contribute to the etiology of Moebius syndrome...
  12. Microarray Analysis of Limb Bud Reaction to Teratogen E*
    William Scott; Fiscal Year: 2003
    ..e., postaxial right forelimb ectrodactyly. Moreover, a number of these agents are well documented human teratogens such as valproic acid, retinoic acid, and ethanol...
  13. GENOTYPE AND PHENOTYPE OF BRAINSTEM INJURY IN AUTISM
    Patricia Rodier; Fiscal Year: 2007
    ..investigators will study the neuroanatomy of animal models and quantify gene expression in embryos exposed to teratogens, using real-time PCR and in situ hybridization...
  14. DNA DAMAGE DURING AGING OF POSTMITOTIC CELLS
    JAMES GAUBATZ; Fiscal Year: 1990
    ..Among environmental factors which have been implicated as carcinogens and teratogens are N-nitroso compounds. N-nitroso compounds are common in our external and internal environments...
  15. CONTROL MECHANISMS IN DIABETES AND NORMAL METABOLISM
    BOYD METZGER; Fiscal Year: 1991
    ..The studies focus on early organogenesis insofar as vulnerability to all teratogens is greatest and the embryo's metabolic repertoire is most limited at that time...
  16. EARLY DEVELOPMENTAL GENES AND AUTISM
    Patricia Rodier; Fiscal Year: 2000
    ..Identification of a mutation underlying autism would allow a clinical test r the deficit and the creation of transgenic animals in which teratogens coul be tested for the potential to trigger the disease.
  17. TRANSCRIPTIONAL REGULATION OF RETINOID ACTION
    Paul Nugent; Fiscal Year: 2000
    ..Research on the molecular mechanisms by which known teratogens produce malformations is important both for our understanding of the particular teratogenic processes, and also ..
  18. VITAMIN A SIGNALING AND CARDIAC MORPHOGENIC DEFECTS
    Kenneth Chien; Fiscal Year: 2003
    ..Retinoids are potent human teratogens linked to several types of birth defects, including cardiovascular anomalies, while vitamin A deficiency can ..
  19. DYNAMICS OF PROTEIN METABOLISM IN RAT CONCEPTUS
    DAVID BECKMAN; Fiscal Year: 1990
    ..growth) and protein degradation during organogenic and histogenic periods of gestation and the effect of teratogens, i.e...
  20. EXOGENOUS RECEPTOR PROBES OF SIGNALLING IN EMBRYOGENESIS
    WILLIAM BUSA; Fiscal Year: 1993
    ..has received little serious study, yet it is at precisely this chemical step where, we may suppose, many human teratogens (e.g., lithium, retinoic acid, etc.) are likely to exert their developmental effects...
  21. ROLE OF H-2 IN ORAL-FACIAL DEVELOPMENT
    Tina Jaskoll; Fiscal Year: 1990
    ..Since certain teratogens (corticosteroids, phenytoin) are known to disturb craniofacial development and their ability to induce such ..
  22. MOLECULAR BASIS OF TOXICANT INDUCED VERTEBRAL ANOMALIES
    Rocky Tuan; Fiscal Year: 2001
    ..embryo represents a crucial morphogenetic phase that is highly susceptible to the action of toxicants and teratogens resulting in skeletal developmental anomalies...
  23. ABNORMAL FETAL DEVELOPMENT DUE TO TOXIC EXPOSURE
    MRINAL SANYAL; Fiscal Year: 1991
    ..on the capability of human placental tissues to transform proteratogens into reactive toxic metabolites (teratogens) harmful to developing embryos...
  24. SONIC HEDGEHOG AND CYCLOPAMINE INDUCED HOLOPROSENCEPHALY
    Henk Roelink; Fiscal Year: 2001
    ..effects of cyclopamine and related steroidal alkaloids, and to characterize the structural properties of teratogens which mediate these effects...
  25. BXR SIGNALING IN VERTEBRATE DEVELOPMENT
    Bruce Blumberg; Fiscal Year: 2004
    ..of developmental signaling molecules and their receptors could lead to the identification of novel morphogens, teratogens, and hormones...
  26. DEVELOPMENTAL REGULATION OF MATRIX-MODELING GENES
    Brigid Hogan; Fiscal Year: 1993
    ..expression of these genes is regulated in time and space during embryogenesis and how this may be perturbed by teratogens or congenital abnormalities...
  27. THE HEAT SHOCK RESPONSE: POTENTIAL TO SCREEN TERATOGENS
    Richard Finnell; Fiscal Year: 1990
    ..an inexpensive screening procedure like the Ames in vitro Salmonella assay needs to be developed for detecting teratogens. However, the success of the Ames assay rests on the fact that the mechanism by which agents induce mutagenicity ..
  28. MIXTURE TERATOGENESIS--RELATION TO MECHANISMS AND QSARS
    DOUGLAS DAWSON; Fiscal Year: 1992
    ..if a consistent relationship exists between teratogenic joint actions and the mechanism(s) of chemical teratogens. Since 65 to 70% of human malformations cannot be attributed to any one cause, the possibility of multiple ..
  29. NEURAL CREST CELLS IN CRANIOFACIAL DEVELOPMENT
    LAURA ROMAN; Fiscal Year: 2000
    ..Like humans, the formation of the anterior structures of the zebrafish embryo is sensitive to teratogens like RA...
  30. Molecular Genetic Analysis of Dandy-Walker Malformation
    Kathleen Millen; Fiscal Year: 2005
    ..Although common, the specific causes of DWM remain undefined. While it is certain that environmental teratogens can cause DWM during embryogenesis, there is clear evidence that as yet undefined genetic factors are also ..
  31. Effects of PCBs on social behavioral development
    HOWARD CROMWELL; Fiscal Year: 2009
    ..with the National Institute of Child Health and Development in that we are interested in optimizing patterns of psychological organization and reducing in the influence of harmful factors like teratogens from the developmental process.
  32. Environmental factors in the etiology of glaucoma
    John Schenkman; Fiscal Year: 2006
    ..The expression of CYP1B1 is affected by wide spectrum of environmental pollutants including known teratogens such as dioxin...
  33. miRNA-MEDIATED MODULATION OF NEURAL PROGENITOR CELL FATE
    Beverly Davidson; Fiscal Year: 2009
    ..Recent work has shown that miRNAs participate in teratogen-mediated changes. We also know that teratogens impair proliferation of neural progenitors...
  34. QUANTITATIVE SPERMATOGENESIS IN CULTURE
    Dominic Poccia; Fiscal Year: 1993
    ..not only yield valuable basic information about spermatogenesis, but will be useful for identifying toxins or teratogens affecting germ line development and for product safety testing...
  35. REGULATION OF MORPHOGENESIS BY IONS, CAMP AND INOSITIDES
    WILLIAM BUSA; Fiscal Year: 1991
    ..b>Teratogens are often employed in the study of pattern formation, in particular the lithium ion, but its pathological ..
  36. CHROMATIN-GLUCOCORTICOID INFLUENCES IN CLEFT PALATE
    ISAAC BEKHOR; Fiscal Year: 1980
    ..Such data will aid in understanding as to how clefting may occur in A/J mice in response to the exposure to teratogens, and may also aid in the final analysis as to how teratogens may influence development of the human embryo.
  37. MOLECULAR MECHANISMS OF CYCLOPHOSPHAMIDE TERATOGENESIS
    Philip Mirkes; Fiscal Year: 1992
    ..More significant is the observation that teratogens kill certain cells in the embryo but spare others, i.e., teratogen exhibit cell-specific cytotoxicity...
  38. MODULATION OF GLUTAMATE SYNAPSES IN NEONATAL CORTEX
    Michael Friedlander; Fiscal Year: 2004
    ..Down Syndrome, Fragile X, Angelman Syndrome, Praeder-Willi Syndrome, William's Syndrome), prenatal exposure to teratogens (e.g., ethanol) and severe neonatal seizures...
  39. Positional cloning of a gene for mental retardation
    Joseph Higgins; Fiscal Year: 2004
    ..Structural brain injury, chromosomal anomalies, malformation syndromes, and teratogens cause MR in some individuals, but often the etiology is unknown...
  40. FACULTY RESEARCH ENHANCEMENT SUPPORT PROGRAM
    SUNDAY ADESUYI; Fiscal Year: 2007
    ..The accumulation of these chemicals in the natural environment has created potential hazards as mutagens, teratogens, clastogens, and carcinogens...
  41. HEARING: DEVELOPMENT OF SYNAPTIC CIRCUITS
    CRAIG HENKEL; Fiscal Year: 2005
    ..understanding auditory functions that may be at risk due to genetic anomaly, nutritional imbalance, effects of teratogens during pregnancy or perhaps even to premature birth...
  42. EYE MALFORMATIONS INDUCED BY TERATOGEN EXPOSURE
    Cynthia Cook; Fiscal Year: 1990
    ..may indicate similar mechanisms of action or effects on similar cell populations for these chemically dissimilar teratogens. Both vitamin A and ethanol are agents to which pregnant women could be intentionally exposed at doses which ..
  43. STEM CELL TECHNOLOGIES FOR TOXICOLOGY ASSESSMENT
    RALPH SNODGRASS; Fiscal Year: 2000
    ..Known teratogens or toxins for adult organs (liver, heart, & nervous system) will be evaluated for their effects on the in ..
  44. Managing Environmental Risks in Pregnancy
    LISA MCELANEY; Fiscal Year: 2006
    ..about the health advantages of screening, assessing and mitigating potential exposure to known and suspected teratogens and environmental toxicants that pose a risk to the developing fetus...
  45. Dioxin and Cardiomyocyte Growth Arrest
    EVAN THACKABERRY; Fiscal Year: 2004
    ..TCDD) and similar environmental contaminates have been shown to be potent cardiovascular teratogens in all species tested...
  46. BIOSTATISTICAL TOPICS IN CARCINOGENICITY AND TERATOLOGY
    Louise Ryan; Fiscal Year: 1992
    ..The project's broad aim is to develop practical and sound statistical designs and analyses, which lead to reliable risk assessment for carcinogens and teratogens.
  47. IMMUNOLOGIC ASSAY FOR CARCINOGEN SCREENING TEST
    WILLEM COETZEE; Fiscal Year: 1992
    ..The correlation between mutagenicity and carcinogenicity would identify these compounds as potential carcinogens/teratogens. The specific aim is to devise a system using molecular genetics, which gives a very rapid, sensitive and easily ..
  48. TISSUE INTERACTIONS IN EAR DEVELOPMENT AND HOMEOSTASIS
    Paul Maderson; Fiscal Year: 1980
    ..High mortalities, and extreme cranio-facial defects seen in avian embryos treated with teratogens during neural crest cell migration and poliferation, suggest that primary genetic lesions of these cells would ..
  49. DRUG METABOLISM: SUSCEPTIBILITY TO DELAYED TERATOGENESIS
    Bernard Shapiro; Fiscal Year: 2002
    ..Using MSG and PB as paradigms of "soft" teratogens, we now propose to investigate our hypothesis that at the time of perinatal exposure, these compounds interfere ..
  50. TERATOGENS AS PROBES OF SONIC HEDGEHOG SIGNALING
    Michael Cooper; Fiscal Year: 2004
    ..abstract not provided..
  51. Fetal DNA oxidation and repair in neurodegeneration
    Peter Wells; Fiscal Year: 2007
    ..These studies will provide mechanistic insight into the fetal origin of environmentally-induced neurodevelopmental defects, and the role of DNA repair activity as a risk factor. ..
  52. MOLECULAR MECHANISMS IN DIABETIC EMBRYOPATHY
    CLAUDIA T KAPPEN; Fiscal Year: 2010
    ..These experiments will generate new and comprehensive insights into the function of pancreatic transcription factors and their pathogenic potential in metabolic disease and fetal development. ..
  53. Redox control of Nrf2/ARE by thioredoxin and GSH
    Jason Hansen; Fiscal Year: 2005
    ..The roles of GSH and cytosolic and nuclear TRX during NRF2 activation and binding will provide an essential foundation for future developmental toxicology. ..
  54. FOLATE AND HOX GENES IN CRANIOFACIAL DEVELOPMENT
    Claudia Kappen; Fiscal Year: 2003
    ..Knowledge about the interactions of genes with environmental factors will be important for designing therapeutic strategies and preventive measures against craniofacial defects. ..
  55. Genetic dissection of skeletal patterning
    Claudia Kappen; Fiscal Year: 2006
    ..The identification of modifier loci that act on skeletal patterning will reveal new molecular mechanisms in skeletal development and has important implications for the evolution of vertebrate body plans. ..
  56. Breast stem cell analysis in random periareolar fine needle aspirates from high r
    BRIAN PETROFF; Fiscal Year: 2008
    ..Overall, this work has the potential to improve our understanding of breast stem cells and cancer risk and refine breast cancer prevention through a novel stem cell-targeted approach. [unreadable] [unreadable] [unreadable]..
  57. Genome-wide discovery of beta cell gene control elements
    Claudia Kappen; Fiscal Year: 2004
    ..Together, our studies will show how speck gene expression is achieved in beta cells and provide a framework to integrate gene transcription and beta cell biology. ..
  58. Aryl hydrocarbon receptor pathway and reproductive aging
    BRIAN PETROFF; Fiscal Year: 2006
    ..abstract_text> ..
  59. AhR and reproductive aging
    BRIAN PETROFF; Fiscal Year: 2008
    ..This project will provide crucial knowledge for the identification and prevention of infertility and birth defects due to the AhR pathway in older mothers. [unreadable] [unreadable] [unreadable]..