Genomes and Genes
Summary: Carcinogenic substances that are found in the environment.
Publications234 found, 100 shown here
- Low-level hexavalent chromium exposure and rate of mortality among US chromate production employeesRose S Luippold
ENVIRON Health Sciences, ENVIRON International Corp, Amherst, Massachusetts 01004 2424, USA
J Occup Environ Med 47:381-5. 2005....
- Exposure determination and respirator selection under the OSHA Hexavalent Chromium StandardsPaul Puncochar
3M Occupational Health and Environmental Safety Division, USA
Occup Health Saf 75:134-9. 2006
- Children and increased susceptibility to environmental carcinogens: evidence or empathy?Christopher Paul Wild
Cancer Epidemiol Biomarkers Prev 12:1389-94. 2003
- Control of the autophagy maturation step by the MAPK ERK and p38: lessons from environmental carcinogensElisabeth Corcelle
INSERM U670, IFR 50, Faculte de Medecine, Avenue de Valombrose, 06107 Nice Cedex 2, France
Autophagy 3:57-9. 2007..We have recently exploited the disruption of autophagy by environmental carcinogens as a powerful model to uncover the underlying signaling pathways...
- Transcriptome analysis in peripheral blood of humans exposed to environmental carcinogens: a promising new biomarker in environmental health studiesDanitsja M Van Leeuwen
Department of Health Risk Analysis and Toxicology, Maastricht University, Maastricht, The Netherlands
Environ Health Perspect 116:1519-25. 2008..Toxicogenomic technologies may improve on this by providing the opportunity to identify molecular biomarkers consisting of altered gene expression profiles...
- Metabolic genotype in relation to individual susceptibility to environmental carcinogensJ A Indulski
The Nofer Institute of Occupational Medicine, Lodz, Poland
Int Arch Occup Environ Health 73:71-85. 2000..the human population there are considerable differences in the response to the carcinogenic activity of environmental carcinogens. Genetic polymorphism associated with several variants of the gene products participating in the ..
- Toward understanding the mutagenicity of an environmental carcinogen: structural insights into nucleotide incorporation preferencesRebecca A Perlow
Department of Biology, New York University, New York, NY 10003, USA
J Mol Biol 322:291-309. 2002..Structural rationalization of the incorporation preference opposite (+)-trans-anti-[BP]-N(2)-dG by T7 DNA polymerase contributes to providing a molecular explanation for mutations caused by this carcinogen-DNA adduct in a model system...
- Importance of chromium-DNA adducts in mutagenicity and toxicity of chromium(VI)Anatoly Zhitkovich
Department of Pathology and Laboratory Medicine, Brown University, Box G E507, Providence, Rhode Island 02912, USA
Chem Res Toxicol 18:3-11. 2005
- Assessing exposure misclassification by expert assessment in multicenter occupational studiesAndrea t Mannetje
International Agency for Research on Cancer, Lyon, France
Epidemiology 14:585-92. 2003..We performed an interteam agreement study to estimate the levels of exposure misclassification and the expected attenuation of the risk estimate...
- Frequent mutations of p53 gene in oesophageal squamous cell carcinomas with and without human papillomavirus (HPV) involvement suggest the dominant role of environmental carcinogens in oesophageal carcinogenesisF Chang
Department of Pathology, University of Kuopio, Finland
Br J Cancer 70:346-51. 1994..The presence of frequent mutations of p53 gene in both HPV-positive and -negative oesophageal carcinomas suggests a dominant role of environmental carcinogens in oesophageal carcinogenesis.
- Direct oxidation of guanine and 7,8-dihydro-8-oxoguanine in DNA by a high-valent chromium complex: a possible mechanism for chromate genotoxicityK D Sugden
Department of Chemistry, The University of Montana, Missoula, Montana 59812, USA
Chem Res Toxicol 14:1315-22. 2001..These results also suggest how high-valent chromium can act as a cocarcinogen with 8-oxo-G-forming xenobiotics...
- Validation of biomarkers for the study of environmental carcinogens: a reviewValentina Gallo
Department of Epidemiology and Public Health, Imperial College London, London, UK
Biomarkers 13:505-34. 2008..Immunoassays for the quantification of adducts of N-nitroso compounds are useful for large epidemiological studies, given their sensitivity, the small amount of DNA required and their potential for rapid and high-throughput analysis...
- The use of common genetic polymorphisms to enhance the epidemiologic study of environmental carcinogensN Rothman
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA
Biochim Biophys Acta 1471:C1-10. 2001..Finally, by gaining a more comprehensive understanding of environmental and genetic risk factors, there should emerge new clinical and public health strategies aimed at preventing and controlling cancer...
- Do extremely low frequency magnetic fields enhance the effects of environmental carcinogens? A meta-analysis of experimental studiesJukka Juutilainen
University of Kuopio, Department of Environmental Sciences, Kuopio, Finland
Int J Radiat Biol 82:1-12. 2006..This paper is a meta-analysis of data from in vitro studies and short-term animal studies that have combined extremely low frequency magnetic fields with known carcinogens or other toxic physical or chemical agents...
- The multitude and diversity of environmental carcinogensD Belpomme
Department of Medical Oncology, European Hospital Georges Pompidou HEGP, University of Paris, F 75015Paris, France
Environ Res 105:414-29. 2007....
- Genotoxicity and physicochemical characteristics of traffic-related ambient particulate matterTheo M de Kok
Department of Health Risk Analysis and Toxicology, University Maastricht, The Netherlands
Environ Mol Mutagen 46:71-80. 2005..This implies that emission reduction strategies that take chemical and toxicological characteristics of PM into account may be useful for reducing the health risks associated with PM exposure...
- Expression of common chromosomal fragile site genes, WWOX/FRA16D and FHIT/FRA3B is downregulated by exposure to environmental carcinogens, UV, and BPDE but not by IRElangovan Thavathiru
Department of Carcinogenesis, The University of Texas M D Anderson Cancer Center, Science Park Research Division, Smithville, Texas 78957, USA
Mol Carcinog 44:174-82. 2005..Here we report that environmental carcinogens, ultraviolet (UV) light, and Benzo[a]pyrene diol epoxide (BPDE), significantly downregulate expression ..
- Mesothelioma and asbestosGraham W Gibbs
Safety Health Environment International Consultants Corp, Alta, Canada
Regul Toxicol Pharmacol 52:S223-31. 2008..To date there is no indication of an increased risk of mesothelioma resulting from non-commercial fiber exposure in the taconite industry...
- Occupational cancer among women: where have we been and where are we going?Shelia Hoar Zahm
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, Maryland 20892 7242, USA
Am J Ind Med 44:565-75. 2003....
- Environmental carcinogens and p53 tumor-suppressor gene interactions in a transgenic mouse model for mammary carcinogenesisDaniel Medina
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
Environ Mol Mutagen 39:178-83. 2002..These results demonstrate that, on a background of underlying genetic instability, very low doses of environmental mutagens and mitogens can produce strong cocarcinogenic effects...
- A tale of two dieselsJanet Arey
Air Pollution Research Center, Department of Environmental Sciences, Interdepartmental Graduate Program in Environmental Toxicology, 211 Fawcett Laboratory, University of California Riverside, Riverside, CA 92521, USA
Environ Health Perspect 112:812-3. 2004..e., SRMs) that can be shared and exhaustively characterized. This needs to be a continuing process as diesel engines, fuels, and exhaust components evolve in response to control regulations...
- Continuing exposure to hexavalent chromium, a known lung carcinogen: an analysis of OSHA compliance inspections, 1990-2000Peter Lurie
Public Citizen s Health Research Group, Washington, DC 20009, USA
Am J Ind Med 42:378-83. 2002..In 1993, Public Citizen and the Paper, Allied-Industrial, Chemical and Energy Workers International Union (PACE) petitioned to lower the PEL from the current 100 microg/m(3) to 0.5 microg/m(3) as an 8-hr time-weighted average (TWA)...
- Genetic toxicology data in the evaluation of potential human environmental carcinogensM D Waters
US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Mutat Res 437:21-49. 1999..Ethylene oxide is cited as an example...
- Hexavalent chromium study's conclusions unjustifiedAltoon Dweck
J Occup Environ Med 47:980-1; author reply 981. 2005
- Effect of coupled dissolution and redox reactions on Cr(VI)aq attenuation during transport in the sediments under hyperalkaline conditionsNikolla P Qafoku
Pacific Northwest National Laboratory, Richland, Washington 99352, USA
Environ Sci Technol 37:3640-6. 2003....
- Hexavalent chromium exposures during full-aircraft corrosion controlGary N Carlton
72nd Medical Group, Tinker AFB, OK, USA
AIHA J (Fairfax, Va) 64:668-72. 2003..5 microg/m(3) for strontium chromate. In the absence of a change from chromated to nonchromated conversion coats and primers, additional control measures are needed to reduce these exposures...
- Allegations of manipulation lead to withdrawal of Cr(VI) reportRebecca Renner
Environ Sci Technol 37:276A-277A. 2003
- Developing risk-based target concentrations for carcinogenic polycyclic aromatic hydrocarbon compounds assuming human consumption of aquatic biotaCatherine Petito Boyce
Gradient Corporation, Mercer Island, Washington 98040, USA
J Toxicol Environ Health B Crit Rev 6:497-520. 2003..03 microg/l...
- Primary DNA damage in chrome-plating workersA Gambelunghe
Department of Clinical and Experimental Medicine, Division of Occupational Medicine, University of Perugia, Via E dal Pozzo, 06126, Perugia, Italy
Toxicology 188:187-95. 2003..The increase in DNA strand-breaks measured by comet assay suggests this test is valid for the biological monitoring of workers exposed to genotoxic compounds such as chromium (VI)...
- Workplace airborne hexavalent chromium concentrations for the Painesville, Ohio, chromate production plant (1943-1971)D M Proctor
Exponent, Irvine, California, USA
Appl Occup Environ Hyg 18:430-49. 2003..039 mg/m(3). Although in some ways limited, these data are of sufficient quality to allow for exposure reconstruction for workers employed at this plant from 1940 to 1972, and to provide the basis for an improved cancer risk assessment...
- Chromium redox speciation in natural watersSean Comber
WRc NSF, Henley Road, Medmenham, Marlow, Buckinghamshire, UK SL7 2HD
J Environ Monit 5:410-3. 2003..The presence of oxidisable organic matter and the stabilising role of complexing organic ligands are proposed as the main controlling influences of redox speciation in filtered samples...
- Cytogenetic effects of hexavalent chromium in BulgariaA K Nersesyan
Mutat Res 538:181-2; author reply 183-4. 2003
- Distribution of chromium contamination and microbial activity in soil aggregatesTetsu K Tokunaga
Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
J Environ Qual 32:541-9. 2003..Typical methods of soil sampling and analyses that average over redox gradients within aggregates can erase important biogeochemical spatial relations necessary for understanding these environments...
- Lung cancer mortality in the German chromate industry, 1958 to 1998David Michaels
J Occup Environ Med 48:995-7; author reply 997-8. 2006
- Human health risk and exposure assessment of chromium (VI) in tap waterDennis J Paustenbach
ChemRisk, Alameda, California, USA
J Toxicol Environ Health A 66:1295-339. 2003..These conclusions are consistent with those recently reached by a panel of experts convened by the State of California...
- Determination of total and hexavalent chromium concentrations in the atmosphere of the city of IsfahanS M Talebi
Department of Chemistry, Isfahan University, P O Box 81745 137, Isfahan 81744, Iran
Environ Res 92:54-6. 2003..Atmospheric levels of total and hexavalent chromium were also investigated in different months of the year, and maximum concentrations were found in October...
- Sampling and analysis considerations for the determination of hexavalent chromium in workplace airKevin Ashley
Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, Ohio 45226 1998, USA
J Environ Monit 5:707-16. 2003..This paper reviews the state of the art concerning the measurement of airborne Cr(VI) compounds in workplace aerosols and related samples...
- Spectrophotometric studies on the investigation of chromium in environmental samplesM B Melwanki
Department of Chemistry, Karnatak University, Dharwad 580 003, India
Indian J Environ Health 45:25-8. 2003..28 ng cm(-2). Beer's law is valid over the concentraction range of 0.1-1.9 mg/l with an optimum concentration range of 0.2-1.7 mg/l. The method has been successfully applied to the analysis of chromium in environmental samples...
- [Examination of nickel and chromium contents in selected herbs, herbal fruit teas and their infusions]Jadwiga Błoniarz
Zakład Bromatologii, Akademii Medycznej w Lublinie
Przegl Lek 61:58-62. 2004..Infusions or decoctions of the examined herbs and herbal fruit teas contain the amounts of these elements that do not harm health and may constitute an additional source of nickel and chromium for the human organism...
- Size distribution and speciation of chromium in paint spray aerosol at an aerospace facilityRania A Sabty-Daily
Health Science Program, 5151 State University Drive, California State University, Los Angeles, CA 90032 8171, USA
Ann Occup Hyg 49:47-59. 2005..The use of Cr(VI) stabilizing sampling media and the storage of samples at lower temperatures (4 degrees C ) during and after sampling may avoid the underestimation of Cr(VI)...
- Surfactant protein B gene variations and susceptibility to lung cancer in chromate workersAshraf A Ewis
Single Molecule Bioanalysis Laboratory, National Institute of Advanced Industrial Science and Technology AIST, Takamatsu, Japan
Am J Ind Med 49:367-73. 2006....
- Selected science: an industry campaign to undermine an OSHA hexavalent chromium standardDavid Michaels
Project on Scientific Knowledge and Public Policy, Department of Environmental and Occupational Health, The George Washington University School of Public Health and Health Services, Washington, DC 20037, USA
Environ Health 5:5. 2006....
- Predicting the toxicity of chromium in sedimentsWalter J Berry
U S Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Atlantic Ecology Division, 27 Tarzwell Drive, Narragansett, Rhode Island 02882, USA
Environ Toxicol Chem 23:2981-92. 2004..abdita was elevated. These results demonstrate that measurements of AVS and interstitial water chromium can be useful in predicting the absence of acute effects from Cr contamination in sediments...
- Sequence specificity of Cr(III)-DNA adduct formation in the p53 gene: NGG sequences are preferential adduct-forming sitesHirohumi Arakawa
Department of Environmental Medicine, Pathology and Medicine, New York University School of Medicine, Tuxedo, NY 10987, USA
Carcinogenesis 27:639-45. 2006..It has been found that Cr(III)-DNA adducts induce mainly G to T mutations. Therefore, these results suggest that Cr(III)-DNA adduct formation contributes to the p53 gene mutations in lung carcinogenesis...
- Estimating historical occupational exposure to airborne hexavalent chromium in a chromate production plant: 1940--1972D M Proctor
Exponent, Irvine, California, USA
J Occup Environ Hyg 1:752-67. 2004....
- Interindividual variability in response to sodium dichromate-induced oxidative DNA damage: role of the Ser326Cys polymorphism in the DNA-repair protein of 8-oxo-7,8-dihydro-2'-deoxyguanosine DNA glycosylase 1Amanda J Lee
School of Biosciences, The University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom
Cancer Epidemiol Biomarkers Prev 14:497-505. 2005..In conclusion, the homozygous Cys(326) genotype may represent a biomarker of individual susceptibility of lung cancer risk in individuals that are occupationally exposed to CrVI...
- Risk estimation for carcinogens based on epidemiological data: a structured approach, illustrated by an example on chromiumR Alexandra Goldbohm
TNO Quality of Life, Business Unit Food and Chemical Risk Analysis, Zeist, The Netherlands
Regul Toxicol Pharmacol 44:294-310. 2006..e., a state-of-the-art risk estimate with confidence intervals, based on all available evidence of sufficient quality...
- Field method for the determination of insoluble or total hexavalent chromium in workplace airKyle J Hazelwood
US Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Spokane, Washington 99207, USA
J Occup Environ Hyg 1:613-9. 2004..Furthermore, the modified procedure met desired performance criteria established for air sampling and analytical methods...
- Chromium(VI) enhances (+/-)-anti-7beta,8alpha-dihydroxy-9alpha,10alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene-induced cytotoxicity and mutagenicity in mammalian cells through its inhibitory effect on nucleotide excision repairWenwei Hu
Department of Environmental Medicine, Pathology, and Medicine, New York University School of Medicine, Tuxedo, New York 10987, USA
Biochemistry 43:14282-9. 2004....
- Individual susceptibility to hexavalent chromium of workers of shoe, hide, and leather industries. Immunological pattern of HLA-B8, DR3-positive subjectsFiorenzo Mignini
Sezione di Anatomia Umana Dipartimento di Scienze Farmacologiche e Medicina Sperimentale, via M Scalzino no 3, Universita di Camerino, 62032, Italy
Prev Med 39:767-75. 2004....
- Genetic and cellular mechanisms in chromium and nickel carcinogenesis considering epidemiologic findingsArthur Chiu
National Center for Environmental Assessment, Office of Research and Development, US Environmental Protection Agency, Washington, DC 20460, USA
Mol Cell Biochem 255:181-94. 2004..Both metals primarily affect initiation processes in cancer development suggesting important theoretical approaches to prevention and followup...
- On the carcinogenicity risk assessment of chromium compoundsMarkku Nurminen
Am J Ind Med 45:308-9; author reply 310. 2004
- Determination of Cr(VI) using an ion selective electrode with SLMs containing Aliquat336Young Woo Choi
Department of Environmental Science and Engineering, Kwangju Institute of Science and Technology, Oryong dong, Buk Gu, Gwangju, Korea
Environ Monit Assess 92:163-78. 2004..The selectivity coefficients and detection limits for the Cr(VI). against the interfering ions, were determined experimentally using the fixed interference (FIM) and the separate solution methods (SSM)...
- Gut microflora & toxic metals: chromium as a modelR K Upreti
Biomembrane Division, Industrial Toxicology Research Centre, Lucknow, India
Indian J Med Res 119:49-59. 2004..The data discussed here with reference to chromium show that gut microflora have a marked capacity to cope with the increased load of ingested metals and may contribute significantly in the protection against metal toxicity...
- Accumulation of chromium and nickel metals in lung tumors from lung cancer patients in TaiwanChung Yih Kuo
Department of Public Health, College of Health Care and Management, Chung Shan Medical University, Taichung, Taiwan, Republic of China
J Toxicol Environ Health A 69:1337-44. 2006..Data suggest that accumulation of Cr and Ni in lung tumors may play a role, at least in part, in the development of lung cancer in Taiwan...
- [Environmental and biological monitoring of exposure to polycyclic aromatic hydrocarbons in workers of an electric steel foundry]E Bergamaschi
Dipartimento di Clinica Medica, Nefrologia e Scienze della Prevenzione, Sezione di Medicina del Lavoro e Tossicologia Industriale, Universita degli Studi di Parma
Med Lav 96:390-402. 2005..To assess and classify exposure to Polycyclic Aromatic Hydrocarbons (PAHs) in some specific working areas of a steel foundry operating with a continuous casting process and evaluate biomonitoring data in different job tasks...
- Determination of total chromium in environmental water samplesJeffrey L Parks
Department of Civil and Environmental Engineering, Virginia Tech University, Durham 418, Blacksburg, VA 24061, USA
Water Res 38:2827-38. 2004..Additionally, field data from several hundred water utility samples are presented to illustrate the potential for incomplete recovery of total chromium using accepted protocols...
- Waterborne and dietary hexavalent chromium exposure causes DNA-protein crosslink (DPX) formation in erythrocytes of largemouth bass (Micropterus salmoides)Jim R Kuykendall
Ohio Northern University, Raabe College of Pharmacy, Ada, OH 45810, USA
Aquat Toxicol 78:27-31. 2006..Further, it may be difficult to achieve dietary Cr(VI) levels high enough to elicit DPXs in predatory fish under most environmental exposure scenarios...
- A remote in situ monitor based on continuous flow analysis for the quantitation of sub-micromolar levels of hexavalent chromium in natural watersMelissa A Singer Pressman
Department of Chemistry and Biochemistry, University of Wisconsin Milwaukee, 53211, USA
J Environ Monit 7:809-13. 2005..23% and the variation in a 0.50 mg l(-1) Cr(vi) standard was 3.8%(n= 11). Known interferences to the DPC chemistry (Mo, V, and Hg at >5 mg l(-1)) were undetected in the harbor water by ICP-MS...
- The relationship between biomarkers of oxidative DNA damage, polycyclic aromatic hydrocarbon DNA adducts, antioxidant status and genetic susceptibility following exposure to environmental air pollution in humansRajinder Singh
Cancer Biomarkers and Prevention Group, Biocentre, University of Leicester, University Road, Leicester, LE1 7RH UK
Mutat Res 620:83-92. 2007..This effect was not observed for individuals carrying the null variant...
- Biomarkers of exposure to carcinogenic PAHs and their relationship with environmental factorsEmanuela Taioli
University of Pittsburgh Cancer Center, 5150 Centre Avenue, Pittsburgh, PA 15232, USA
Mutat Res 620:16-21. 2007..The B[a]P DNA adducts were more strongly associated with smoking status than with the environmental exposure to c-PAHs...
- Environmental exposure to carcinogenic polycyclic aromatic hydrocarbons--the interpretation of cytogenetic analysis by FISHRadim J Sram
Laboratory of Genetic Ecotoxicology, Institute of Experimental Medicine AS CR, v v i, and Health Institute of Central Bohemia, Videnska 1083, 142 20 Prague 4, Czech Republic
Toxicol Lett 172:12-20. 2007..This is the first study reporting that translocations induced by c-PAHs in peripheral lymphocytes last only several weeks...
- Effect of microbial activity on the mobility of chromium in soilsV Desjardin
LAEPSI, INSA de Lyon, Villeurbanne, France
Waste Manag 22:195-200. 2002..thermocarboxydus was induced, or significantly accelerated, by the aggregation of bacterial cells or their adhesion to suspended solid particles, and was stimulated in pure culture by glycerol and chromate...
- Cytogenetic effects of hexavalent chromium in Bulgarian chromium platersDonka Benova
National Center of Radiobiology and Radiation Protection NCRRP, Laboratory of Radiation Mutagenesis and Embryology, 132 Kliment Ochridski Blvd, 1756, Sofia, Bulgaria
Mutat Res 514:29-38. 2002..No difference between C(+) and C(-) MN frequencies was found in the lymphocytes as well as in the buccal cells. Thus, Cr(VI) appears to have both clastogenic as well as aneugenic effects in humans...
- Assessment of fumonisin exposure to infants consuming maize based complementary foods in Rombo District of TanzaniaM Kimanya
Tanzania Food and Drugs Authority, Dar es Salaam, Tanzania
Commun Agric Appl Biol Sci 72:13-7. 2007
- Chromate concentration bias in primer paint particlesP T LaPuma
Air Force Institute of Technology, Wright-Patterson AFB, Ohio, 45433, USA
Regul Toxicol Pharmacol 33:343-9. 2001....
- Quality of indoor residential air and healthRobert Dales
The University of Ottawa, Ottawa, ON
CMAJ 179:147-52. 2008..Homeowners can improve the air quality in their homes, often with relatively simple measures, which should provide health benefits...
- A study on hexachromic ion selective electrode based on supported liquid membranesY W Choi
Department of Environmental Science and Engineering and Advanced Environmental Monitoring Research Center, Kwangju Institute of Science and Technology, Korea
Environ Monit Assess 70:167-80. 2001..Selectivity coefficients and detection limits of Cr(VI) in the presence of interfering ions were determined experimentally using the fixed interference method...
- Toxicity and bioaccumulation of arsenic and chromium in epigean and hypogean freshwater macroinvertebratesV Canivet
UMR-CNRS no. 5023, , Equipe d'Hydrobiologie et Ecologie Souterraines, , 43 Bd du 11 Novembre 1918, 69622 Villeurbanne Cedex, France
Arch Environ Contam Toxicol 40:345-54. 2001....
- Environmental and biological monitoring of occupational exposure to organic micropollutants in gasolineC Senzolo
Department of Environmental Sciences, University of Venice, Italy
Chemosphere 44:67-82. 2001..The most exposed department, one in which tank-lorries were loaded, needs further investigation and extended monitoring...
- Effects of diet on biomarkers of exposure and effects, and on oxidative damageSara Raimondi
Fondazione Policlinico, Milano, Italy
Mutat Res 620:93-102. 2007..The recent consumption of smoked or fried food was associated with an increase in total DNA adducts levels...
- Glass-based radon-exposure assessment and lung cancer riskFrederic Lagarde
Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
J Expo Anal Environ Epidemiol 12:344-54. 2002..This suggests that surface-based estimates may provide a more relevant exposure proxy than air-based estimates for relating past radon exposure to lung cancer risk...
- Reductive activation with cysteine represents a chromium(III)-dependent pathway in the induction of genotoxicity by carcinogenic chromium(VI)Anatoly Zhitkovich
Department of Pathology and Laboratory Medicine, Brown University, Box G B511, Providence, RI 02912, USA
Environ Health Perspect 110:729-31. 2002..The demonstration of the mutagenic potential of Cr-DNA adducts suggests that these lesions can be explored in the development of specific and mechanistically important biomarkers of exposure to toxic forms of Cr...
- The effects of chromium VI on the fitness and on the beta-tubulin genes during in vivo development of the nematode Steinernema feltiaeStephen Boyle
Molecular Ecology and Nematode Research Group, Department of Science and Health, Institute of Technology Carlow, Kilkenny Road, Carlow, Ireland
Sci Total Environ 404:56-67. 2008..These findings constitute this organism appropriate for further investigation for the development of sub-lethal end points and biomarkers for the detection and biomonitoring of chromium VI contamination in soil...
- Postdeployment evaluation of health risk communication after exposure to a toxic industrial chemicalJames D Mancuso
Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
Mil Med 173:369-74. 2008....
- Fanconi anemia complementation group A cells are hypersensitive to chromium(VI)-induced toxicitySusan K Vilcheck
Department of Pharmacology, Program in Molecular and Cellular Oncology, The George Washington University Medical Center, 2300 Eye Street NW, Washington, DC 20037, USA
Environ Health Perspect 110:773-7. 2002..The results also suggest that Cr-DDC may be proapoptotic lesions. These results are the first to show that FA cells are hypersensitive to an environmentally relevant DNA cross-linking agent...
- In situ treatment of chromium-contaminated groundwaterJonathan Fruchter
Environmental Technology Directorate, Pacific Northwest National Laboratory, Richland, Wash, USA
Environ Sci Technol 36:464A-472A. 2002
- [Occupational exposure to hexavalent chromium during aircraft painting]M Gherardi
Istituto Superiore per la Prevenzione e la Sicurezza del Lavoro, Dipartimento Igiene del Lavoro, Via Fontana Candida 1, 00040 Monte Porzio Catone, RM
G Ital Med Lav Ergon 29:553-5. 2007..Moreover the strategy of coupling environmental sampling with biological monitoring seems to be a useful instrument to measure the validity of the individual protection devices...
- Chromate content versus particle size for aircraft paintsPeter T LaPuma
Air Force Institute of Technology Wright Patterson AFB, OH, USA
Regul Toxicol Pharmacol 36:318-24. 2002..7 to 1.0 microm, contained approximately 10% of the Cr(6+) content, per mass of dry paint, compared to particles larger than 7.0 microm. The paint gun settings of air to paint ratio was found to have no influence on the Cr(6+) bias...
- Molecular epidemiology in cancer researchA R Collins
Rowett Research Institute, DNA Instability Group, Bucksburn, Aberdeen, UK
Mol Aspects Med 19:359-432. 1998..investigating the aetiology of the disease; monitoring cancer risk in people exposed to occupational or environmental carcinogens; studying factors that protect from cancer; and assessing intrinsic factors that might predispose to ..
- Environmental and chemical carcinogenesisGerald N Wogan
Biological Engineering Division, Massachusetts Institute of Technology, Room 26 009, Cambridge, MA 02139, USA
Semin Cancer Biol 14:473-86. 2004..This approach can be applied to evaluation of other environmental carcinogens, and the evaluations would be markedly facilitated by prospective epidemiologic studies incorporating ..
- Is secondary leukemia an independent poor prognostic factor in acute myeloid leukemia?Richard A Larson
Department of Medicine and Cancer Research Center, University of Chicago, Chicago, Illinois 60637, USA
Best Pract Res Clin Haematol 20:29-37. 2007..including alkylating agents and topoisomerase II inhibitors, and/or radiotherapy, or due to exposure to environmental carcinogens. Outcomes for this large and variable group of patients with secondary AML have been poor compared to ..
- Possible application of human c-Ha-ras proto-oncogene transgenic rats in a medium-term bioassay model for carcinogensTakamasa Ohnishi
Department of Molecular and Environmental Pathology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
Toxicol Pathol 35:436-43. 2007With the aim of developing a medium-term assay for screening of environmental carcinogens, we exposed mammary carcinogen sensitive human c-Ha-ras proto-oncogene transgenic (Hras128) rats to various carcinogens, including compounds that ..
- Oral cancer prevention and control--the approach of the World Health OrganizationPoul Erik Petersen
Global Oral Health Programme, World Health Organization, 20 Avenue Appia, CH1211 Geneva 27, Switzerland
Oral Oncol 45:454-60. 2009..Low-income and disadvantaged groups are generally more exposed to avoidable risk factors such as environmental carcinogens, alcohol, infectious agents, and tobacco use...
- Glycine N-methyltransferase-/- mice develop chronic hepatitis and glycogen storage disease in the liverShih Ping Liu
Division of Preventive Medicine, Institute of Public Health, School of Medicine, Taipei, Taiwan
Hepatology 46:1413-25. 2007..N-methyltransferase (GNMT) affects genetic stability by regulating DNA methylation and interacting with environmental carcinogens. To establish a Gnmt knockout mouse model, 2 lambda phage clones containing a mouse Gnmt genome were ..
- Examining the joint effect of multiple risk factors using exposure risk profiles: lung cancer in nonsmokersMichail Papathomas
Department of Epidemiology and Biostatistics, Imperial College London, United Kingdom
Environ Health Perspect 119:84-91. 2011..It reduces dimensionality by using as its main unit of inference the exposure profiles of the subjects that is, the sequence of covariate values that correspond to each subject...
- Association between NAD(P)H: quinone oxidoreductase 1 (NQ01) inactivating C609T polymorphism and adenocarcinoma of the upper gastrointestinal tractMario Sarbia
Institute of Pathology, Technical University of Munich, Munchen, Germany
Int J Cancer 107:381-6. 2003NQO1 is an antioxidant enzyme, important in the detoxification of environmental carcinogens. A single nucleotide polymorphism (C-->T) at position 609 of the NQO1 cDNA has been associated with susceptibility to tumours induced by ..
- [Genetic susceptibility and risk of gastric cancer in a human population of Cauca, Colombia]Maria M Torres
Laboratorio de Genetica Humana, Facultad de Ciencias, Universidad de Los Andes, Bogota, DC, Colombia
Biomedica 24:153-62. 2004..Glutathione S-transferase (GST) enzymes are involved in the detoxification of many environmental carcinogens. The homozygous deletions of glutathione S-transferase M1 (GSTM1-0) and glutathione S-transferase T1 (..
- The utility of the guppy (Poecilia reticulata) and medaka (Oryzias latipes) in evaluation of chemicals for carcinogenicityGrace E Kissling
Environmental Medicine and Diseases Program and Environmental Toxicology Program, National Institute of Environmental Health Sciences, 111 T W Alexander Drive, Research Triangle Park, NC 27709, USA
Toxicol Sci 92:143-56. 2006There has been considerable interest in the use of small fish models for detecting potential environmental carcinogens. In this study, both guppies (Poecilia reticulata) and medaka (Oryzias latipes) were exposed in the aquaria water to ..
- Occupational risk factors for breast cancer among women in ShanghaiS A Petralia
Occupational Epidemiology Branch, National Cancer Institute, Bethesda, Maryland, USA
Am J Ind Med 34:477-83. 1998..changes in established breast cancer risk factors, but it is possible that exposure to occupational and environmental carcinogens in Shanghai also have contributed to the rise in incidence...
- Molecular mechanisms of inhibition of photocarcinogenesis by silymarin, a phytochemical from milk thistle (Silybum marianum L. Gaertn.) (Review)Mudit Vaid
Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Int J Oncol 36:1053-60. 2010..Solar UV radiations are considered as the most prevalent environmental carcinogens, and chronic exposure of the skin to UV leads to squamous and basal cell carcinoma and melanoma in human ..
- Novel dithiolethione-modified nonsteroidal anti-inflammatory drugs in human hepatoma HepG2 and colon LS180 cellsSara E Bass
Basic Research Program, Science Applications International Corporation Frederick, Inc, and Laboratory of Metabolism, National Cancer Institute Frederick, Frederick, Maryland, USA
Clin Cancer Res 15:1964-72. 2009..However, the molecular basis mediated by NSAIDs for chemoprevention has not been fully elucidated. Environmental carcinogens induce DNA mutation and cellular transformation; therefore, we examined the effect of NSAIDs on ..
- Expression of arylamine N-acetyltransferases in pre-term placentas and in human pre-implantation embryosV A Smelt
Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK
Hum Mol Genet 9:1101-7. 2000..which show polymorphism, and both enzymes are involved in the activation and detoxification of environmental carcinogens and teratogens...
- Childhood acute lymphoblastic leukemia: genetic determinants of susceptibility and disease outcomeM Krajinovic
Hopital Sainte Justine, Departement de Pediatrie, Universite de Montreal, Canada
Rev Environ Health 16:263-79. 2001..drug resistance is not well understood, differences in the capacity of ALL patients to process drugs and environmental carcinogens could play a role by modifying the risk of recurrent malignancy, as well as the response to therapy...
- Quantitative analysis of aflatoxin-albumin adductsF Z Sheabar
Division of Toxicology, Massachusetts Institute of Technology, Cambridge 02139
Carcinogenesis 14:1203-8. 1993..made using biologically relevant markers will facilitate epidemiological studies of risk from environmental carcinogens. Blood proteins are readily accessible macromolecules that have been shown to be targets for activated ..
- Genetic determinant and environmental carcinogensM Nagao
Carcinogenesis Division, National Cancer Center Research Institute, Tokyo, Japan
Mutat Res 402:85-91. 1998..By mapping the gene, we will be able to identify humans who might belong to high risk group in general population, and cancer can be prevented more efficiently by attaining early diagnosis...
- Electrochemical methods for monitoring of environmental carcinogensJ Barek
Department of Analytical Chemistry, Charles University, Prague, Czech Republic
Fresenius J Anal Chem 369:556-62. 2001..Scope and limitations of these methods are described and some practical applications based on their combination with liquid-liquid or solid phase extraction are given...
- The CYP17 and CYP19 gene single nucleotide polymorphism in women with sporadic breast cancerAnna Sobczuk
Institute of Polish Mother s Memorial Hospital, ul Rzgowska 281 289, 93 338 Łódź
Pol J Pathol 60:163-7. 2009The cytochrome P450 family (CYPs) enzymes play an important role in the metabolism of environmental carcinogens and of oestrogen and can affect breast cancer risk...
- Histone deacetylases (HDACs) in XPC gene silencing and bladder cancerXiaoxin S Xu
Institute of Environmental Health Sciences, Wayne State University, 259 Mack Avenue, Detroit, MI 48201, USA
J Hematol Oncol 4:17. 2011..Bladder cancer is strongly associated with exposure to environmental carcinogens. It is believed that DNA damage generated by environmental carcinogens and their metabolites causes ..
- Apoptosis triggered by DNA damage O6-methylguanine in human lymphocytes requires DNA replication and is mediated by p53 and Fas/CD95/Apo-1Wynand Roos
Division of Applied Toxicology, Institute of Toxicology, Obere Zahlbacher Str 67, D 55131 Mainz, Germany
Oncogene 23:359-67. 2004Various tumor-therapeutic drugs and environmental carcinogens alkylate DNA inducing O(6)-methylguanine (O(6)MeG) that provokes cell death by apoptosis...
- Use of metabolically competent human hepatoma cells for the detection of mutagens and antimutagensS Knasmuller
Institute of Tumor Biology and Cancer Research, University of Vienna, Vienna, Austria
Mutat Res 402:185-202. 1998..It has been demonstrated that various classes of environmental carcinogens such as nitrosamines, aflatoxins, aromatic and heterocyclic amines and polycyclic aromatic hydrocarbons ..
- 24th Annual Fanconi Anemia Research Fund Scientific SymposiumGROVER CARLTON BAGBY; Fiscal Year: 2012..genetic instability of the somatic cells in the FA patient means that exposure to ionizing radiation, environmental carcinogens and chemotherapeutic agents pose unique risks to the patient...
- MECHANISMS OF RADIORESISTANCE AND CELL CYCLE PROGRESSIONHoward B Lieberman; Fiscal Year: 2013..the findings should impact on basic research and public health where DNA damaging agents are prevalent environmental carcinogens that can induce genomic instability and cancer, and at the same time the work should reveal novel ..
- Molecular Mechanisms of Chemoprevention: NRF2 SignalingThomas W Kensler; Fiscal Year: 2013Cancer prevention involving reduction or elimination of human exposure to environmental carcinogens may not always be possible...
- Roles of NF-kB/Rel in the pathogenesis of breast cancerGail E Sonenshein; Fiscal Year: 2012..the PI proposes to test the central hypothesis that genetic and epigenetic alterations mediated by environmental carcinogens converge to induce or enhance the activity of multiple NF-?B complexes, thereby promoting a more ..
- DNA REPAIR IN A HORMONE RESPONSIVE GENEMichael J Smerdon; Fiscal Year: 2013..valuable insight into the cell's defense mechanism for resisting neoplastic transformation by environmental carcinogens. PUBLIC HEALTH RELEVANCE: DNA damage is detrimental to all living cells and repair of these lesions in ..
- Apple peel extract inhibits Cr(VI)-induced lung cancerZhuo Zhang; Fiscal Year: 2013DESCRIPTION (provided by applicant): Cr(VI)-containing compounds are well established environmental carcinogens. Although the mechanisms of Cr(VI) carcinogenesis remain to be investigated, various studies indicate that Cr(VI)-induced ..
- Cancer induction in the ovary by an environmental pollutant, dibenzo[a,l]pyreneKun Ming Chen; Fiscal Year: 2013..Presence of DNA adducts in tissues exposed to environmental carcinogens is crucial to the initiation of the carcinogenic process, and therefore the detection of DNA adducts ..
- Genomic profiling of yeast resistance to AFB1, a P450-activated carcinogenMICHAEL THOMAS FASULLO; Fiscal Year: 2013..However, human susceptibility to environmental carcinogens is highly variable...
- Prevention of EtOH-induced promotion of hepatocarcinogenesis by genistein/soyMartin J J Ronis; Fiscal Year: 2013..promoter, increasing the rate of development of tumors initiated as a result of exposure to dietary and environmental carcinogens such as nitrosamines found in alcoholic beverages and cigarette smoke or via hepatitis infection...
- Mdig gene and histone demethylation in lung cancerFei Chen; Fiscal Year: 2013..of mdig gene may be critical for lung cell proliferation and carcinogenic transformation in response to environmental carcinogens. To accomplish the objectives of this application, we will pursue three specific aims by using cell ..
- P53-dependent responses to toxicants in parous and nulliparous breastD Joseph Jerry; Fiscal Year: 2010Associations between breast cancer and exposure to environmental carcinogens are often weak or inconsistent in the epidemiologic literature, even when strong experimental data exists...
- Genetic and Epigenetic Biomarkers for SCC of the LungSteven A Belinsky; Fiscal Year: 2012..NCI: they will uncover the contribution of single- and double-strand break DNA damage associated with environmental carcinogens to lung cancer and identify biomarkers for risk assessment and early detection of lung cancer, the ..
- The Role of Peroxiredoxin1 &Reactive Oxygen Species in Breast Tumor InitiationCarola Anke Neumann; Fiscal Year: 2013..conditions where H2O2 levels are elevated as found in aging, tobacco smoking, ionizing radiation and environmental carcinogens. By studying breast cancer prone mice lacking Prdx1 we should help to find more specific preventive ..
- Elimination of Carcinogen-Induced Tumor Stem Cells by ATF5 Loss of Function.JAMES ANGELASTRO; Fiscal Year: 2009..Long-term objectives are to determine whether brain neoplasm, arising from environmental carcinogens, promotes transformations of neural stem cells to tumor stem cells that in turn support the growth of ..
- Aromatic Amine-DNA Lesions: Mutagenicity and RepairSuse Broyde; Fiscal Year: 2013DESCRIPTION (provided by applicant): Polycyclic aromatic amines, heterocylic amines and nitroarenes are environmental carcinogens that are present in many cooked and broiled foods, notably meats, products of fuel combustion such as ..
- REPAIR OF CARCINOGEN DAMAGED DNA IN HUMAN CHROMATINMichael J Smerdon; Fiscal Year: 2010..expression of specific genes required for establishing the neoplastic phenotype, these studies should provide valuable insight into the cell's defense mechanism for resisting neoplastic transformation by environmental carcinogens.
- Bypass of DNA lesions by translesion synthesis in yeastLouise Prakash; Fiscal Year: 2013..oxygen species generated during normal cellular oxidative reactions and from exposure to chemical and environmental carcinogens, the TLS processes provide an important means for minimizing the mutagenic effects of DNA damage and for ..
- Carcinogenic Metals And Their Interactions With Other ToxicantsMax Costa; Fiscal Year: 2010..metals have unique as well as multiple mechanisms in causing cancers and can synergize with other environmental carcinogens (i.e...
- Excision of Carcinogen-DNA Adducts in NucleosomesNicholas E Geacintov; Fiscal Year: 2013..of fossil fuel combustion and are present in our air, food and water;the presence of these genotoxic environmental carcinogens in our environment continues to be a hazard to human health...
- Translesion DNA synthesis in humansLouise Prakash; Fiscal Year: 2012..diol epoxide, which result from cellular oxidative damage and from exposure to DNA damaging environmental carcinogens. In Aim 2, studies will be done to test the hypothesis that in human cells, Rev1 functions as a ..
- Mechanisms of ATF3-induced mammary tumorigenesisMichael C MacLeod; Fiscal Year: 2011..that links ATF3 with Wnt/p-catenin signaling and to suggest new mechanisms for the involvement of environmental carcinogens with human tumorigenesis...
- The role of ribosomal proteins in the p53-MDM2 pathwayHua Lu; Fiscal Year: 2013..role of ribosomal proteins (RP), such as RPL11, RPL5, and RPL23, in p53 response to various cellular and environmental carcinogens or chemicals, including endogenous and exogenous compounds, which may cause ribosomal stress, by ..
- Polymerase Interactions with Carcinogen-modified DNAF Peter Guengerich; Fiscal Year: 2013DESCRIPTION (provided by applicant): Many environmental carcinogens, both chemical and physical, cause cancer at least in part by producing mutations, as evidenced by characteristic exposure-related mutation spectra in human cancers and ..
- Energetics of oligonucleotide conformational heterogeneityAlexander D MacKerell; Fiscal Year: 2013..will also be use to facilitate the design of novel gene therapy agents and understand the impact of environmental carcinogens on DNA replication...
- Y-family DNA polymerases and cellular responses to benzo[a]pyreneALDEN C KLARER; Fiscal Year: 2013..advances implicate error-prone DNA polymerases in the generation of virtually all mutations induced by environmental carcinogens in higher eukaryotic cells...
- Molecular Pathways to Pathogenesis in ToxicologyRobert C Smart; Fiscal Year: 2013..Examples of types of environmental agents that will be investigated include environmental carcinogens, pesticides, particulates, metals, endocrine disrupters and nanoparticles...
- Apple Peel Extract Protects UV-Induced CarcinogenesisXianglin Shi; Fiscal Year: 2010..nutritional factors and phytochemicals play an important role in an individual's susceptibility to environmental carcinogens. Understanding of the underlying mechanisms will enhance the effectiveness of prevention and therapeutic ..
- Role of TGFbeta signaling in HNSCC progressionXiao Jing Wang; Fiscal Year: 2013..The major HNSCC etiological factors are environmental carcinogens, e.g...
- Role of Rev1 in error-free replication of DNA damage and in mutation preventionSatya Prakash; Fiscal Year: 2012..from endogenous oxidative damage and from exposure to a number of widespread DNA damaging chemical and environmental carcinogens such as butadiene epoxides and anti-benzo[a]pyrene diol epoxides...
- Signaling Pathways in Stages of TumorigenesisGail E Sonenshein; Fiscal Year: 2012..The overarching hypothesis in our original application was that environmental carcinogens, which induce genetic and epigenetic events, set in motion interacting signaling cascades that promote a ..
- Genome Wide Association Study of Head and Neck CancerSanjay Shete; Fiscal Year: 2013..Therefore, head and neck cancers are an excellent model for studying genetic susceptibility to environmental carcinogens. The primary goal of this R01 application is to perform a comprehensive two-stage, high-density, genome-..
- Comparative Mechanisms of Genomic InstabilityKaren M Vasquez; Fiscal Year: 2010..b>Environmental carcinogens such as irradiation are known to result in more non-B structure formation, and a reduced error-free ..
- Plk3, A New Player In The Hypoxia Regulatory Networ.Wei Dai; Fiscal Year: 2013..of a new mechanism by which HIF-11 is regulated by Plk3 during hypoxic responses or after exposure to environmental carcinogens such as nickel compounds...
- Role of human DNA polymerase kappa in replicative bypass of DNA lesionsSatya Prakash; Fiscal Year: 2013..adducts are formed in human cells from cellular oxidative reactions and from exposure to chemical and environmental carcinogens, Pol? will have a major impact on genome stability by keeping the rate of mutations low, reducing ..
- Function and Regulation of Human Cytochrome P4502S1Oliver Hankinson; Fiscal Year: 2010..Pharmaceuticals and endogenous compounds, and may ultimately provide opportunities for reducing the deleterious effects of environmental carcinogens and the adverse effects of certain Pharmaceuticals in the human population.
- Excision of Environmental Carcinogen-DNA Lesions by Human NER enzymesNicholas E Geacintov; Fiscal Year: 2012..DNA perturbations caused by bulky lesions derived from the reactions of metabolically activated environmental carcinogens that enter the human body...
- Do NFATc2 and cJun Cooperate to Activate Transcription in Breast Cancer Cells?James Goodrich; Fiscal Year: 2013..cJun cooperate to activate transcription of genes that promote breast cancer invasiveness in response to environmental carcinogens known to increase cytosolic calcium. The proposal has three highly focused Specific Aims...
- MITDNA MUTAGENESIS BY ENVIRONMENTAL CARCINOGENSKeshav Singh; Fiscal Year: 2003Human mitochondrial DNA (mitDNA) is extremely vulnerable to attack by environmental carcinogens because it contains no introns, has no protective histones and is continuously exposed to reactive free radicals produced within the ..
- African Americans and Environmental Cancers: Sharing Histories to Build TrustMarie Lynn Miranda; Fiscal Year: 2010..These factors all increase the likelihood of exposure to environmental carcinogens, which may contribute to increased cancer mortality among African Americans...
- INTESTINAL AND COLONIC CYTOCHROME P450 GENE EXPRESSIONPeter Traber; Fiscal Year: 1993..cells lining the small intestine and colon are exposed to many ingested xenobiotics including drugs and environmental carcinogens. Cytochrome P450 isoenzymes, which are encoded by a large superfamily of related genes play an important ..
- ORAL CANCER--DNA POLYMORPHISMS IN CARCINOGEN METABOLISMStephen Schwartz; Fiscal Year: 2001..of this study will contribute to accumulating knowledge regarding the role of genetic susceptibility to environmental carcinogens in determining cancer risk...
- Mechanisms of Trinucleotide Repeat Expansion via Oxidative DNA Damage and RepairYuan Liu; Fiscal Year: 2012..how inefficient processing of oxidative single-strand DNA (ssDNA) break intermediates induced by environmental carcinogens, chromate and bromate may be involved in CAG repeat expansion...
- Regulatory Signaling in Repair of Environmentally Induced DNA DamageMICHAEL LUCA DURANDO; Fiscal Year: 2013DESCRIPTION (provided by applicant): Exposure to ubiquitous environmental carcinogens, such as poly aromatic hydrocarbons and UV light, is cause of human disease...
- AHR-Protac, a novel aryl hydrocarbon receptor antagonistHOLLIE ISABEL SWANSON; Fiscal Year: 2010..develop a novel research tool that can be used to identify how inappropriate activation of the AHR by environmental carcinogens leads to human cancers and to understand the role of the AHR in normal biological processes...
- Green tea catechins in precancerorus preventionHWA CHAIN WANG; Fiscal Year: 2009..GTCs) in precancerous prevention of human breast cancers associated with long-term exposures to environmental carcinogens. Carcinogenesis of breast epithelial cells from non-cancerous to precancerous and cancerous stages is a ..
- Advances in Statistical Methods for Cancer Genetic EpidemiologySanjay Shete; Fiscal Year: 2013..The recent advances in genomics technology, coupled with increasing investigation of putative environmental carcinogens, have led to revolutionary progress in evaluating and identifying genetic and environmental factors for ..
- FUNCTIONAL CHARACTERIZATION OF AGT GENETIC POLYMORPHISMJun yan Hong; Fiscal Year: 2001A large number of environmental carcinogens and toxicants are alkylating agents. Human O6-alkylguanine-DNA alkyltransferase (AGT, EC 2.1.1...
- EFFECTS OF BENZO[A]PYRENE IN TRANSGENIC MODEL OF CERVICAELLEN RORKE; Fiscal Year: 2002..In this regard, environmental carcinogens play a major role. Cigarette smoking is correlated with an enhanced risk for cervical cancer development...
- MECHANISM OF METAL ANTAGONISTIC EFFECT ON BPDE MUTANTSDAVID REINHOLD; Fiscal Year: 1999..the interaction of metals (chromium and nickel) and benz[a]alpyrene diol epoxide (BPDE), all common environmental carcinogens, on the mutant frequency of the hypoxanthine phosphoribosyltransferase (HPRT) gene in normal human ..
- ANAEROBIC METABOLISM OF MUTAGENS IN HUMAN FOODSDavid Kingston; Fiscal Year: 1990..most common organ-site cancer in the United States, is believed to be caused, at least in part, by environmental carcinogens. One important class of environmental carcinogens is the "dietary carcinogens" formed during the cooking ..
- Int5/Aromatase Effect of Breast Estrogen in NeoplasiaRAJESHWAR TEKMAL; Fiscal Year: 2005..chemopreventive agent and B) the chemoprevention with aromatase inhibitors reduces the susceptibility to environmental carcinogens that may, in turn, reduce the occurrence of breast cancer in aromatase mice...
- BIOCHEMICAL TOXICOLOGY OF CYTOCHROME P-450Andrew Parkinson; Fiscal Year: 1990..Addressing such issues serves to broaden the significance of the proposed study, and directs the applicant's long-term goals towards human aspects of toxicology and cancer...
- Biosensor to Detect Polycyclic Aromatic Hydrocarbons (PAHs) in the EnvironmentDaniel F Woods; Fiscal Year: 2013..A sensitive, robust system to identify environmental carcinogens such as polycyclic aromatic hydrocarbons (PAHs) would greatly aid efforts to protect and improve public ..
- MECHANISM OF CARCINOGENESIS OF DIBENZ ACRIDINESubodh Kumar; Fiscal Year: 1991Polycyclic aromatic hydrocarbons (PAHs) and their aza-analogs (aza- PAHs) are ubiquitous environmental carcinogens. PAHs are known to require metabolic activation to their bay-region diol epoxides for producing their carcinogenic effects,..
- Aryl hydrocarbon receptor regulation of the cell cycle by chromatin modificationREBEKA MERSON; Fiscal Year: 2009..The aryl hydrocarbon receptor (AhR) binds to numerous synthetic and natural compounds including environmental carcinogens such as some polyhalogenated aromatic hydrocarbons (e.g...
- Prevention of Head and Neck Carcinogenesis with a Plant-Derived CompoundRebecca Leeman; Fiscal Year: 2009..Project Summary: Head and neck squamous cell carcinoma (HNSCC) is thought to be caused by the effects of environmental carcinogens including tobacco, alcohol, betel quid, organic solvents, coal dust, welding fumes, asbestos, and ..
- HUMAN MISMATCH REPAIR IN CHEMICAL CARCINOGENESISGuo Min Li; Fiscal Year: 2001..b>Environmental carcinogens covalently modify DNA to form carcinogen-DNA adducts, which induce mutations that initiate ..
- Kinetotoxic Mechanisms of Environmental CarcinogensJames Sherley; Fiscal Year: 2007..of the proposed research will be to use these cell lines to evaluate well established non-mutagenic environmental carcinogens for kinetotoxicity. Both acute high-dose and chronic low-dose exposures will be investigated...
- GENOMIC INSTABILITY IN TUMORS OF TRANSGENIC MICEJon Mirsalis; Fiscal Year: 1999..and p53 +/- mice to characterize genomic instability in tumors in response to genotoxic and nongenotoxic environmental carcinogens. The specific aims will be to 1) determine the level of genomic instability in lacI transgenic mouse ..
- GLUCURONIDATION OF DIETARY AND ENVIRONMENTAL CARCINOGENSRobert Tukey; Fiscal Year: 2002....
- PROSTATIC CANCER: GENETIC AND ENDOCRINE RISK FACTORSA Meikle; Fiscal Year: 1980..and predispose men to the early development of prostatic cancer in response to endogenous hormones and environmental carcinogens. Our probands will be less than 61 years of age when the diagnosis of prostatic cancer is made...
- MOLECULAR EPIDEMIOLOGY OF PROSTATE CANCERTimothy Rebbeck; Fiscal Year: 1999..The objective of the present study is to examine the role of genes that regulate the metabolism of environmental carcinogens in prostate cancer etiology. These genes include cytochromes P450 (e.g...
- Roles of Claudin-7 in Lung CancerYan Hua Chen; Fiscal Year: 2009..Specific Aim 2: To investigate environmental carcinogens on the growth of lung carcinoma in vivo and on tumor-host interactions in Cln7 mice...
- 9th International Conference on Environmental Mutagens: Student Travel ExpensesJonathan Ward; Fiscal Year: 2005..toxicological studies and for the development of methods for studying mutations, mutagenic mechanisms, environmental carcinogens, and DNA repair in model cellular systems as well as humans...