environmental pollutants

Summary

Summary: Substances which pollute the environment. Use for environmental pollutants in general or for which there is no specific heading.

Top Publications

  1. pmc Exposure of the U.S. population to bisphenol A and 4-tertiary-octylphenol: 2003-2004
    Antonia M Calafat
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Environ Health Perspect 116:39-44. 2008
  2. ncbi Epigenetic transgenerational actions of endocrine disruptors and male fertility
    Matthew D Anway
    Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, WA 99164 4231, USA
    Science 308:1466-9. 2005
  3. ncbi The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins
    Marc Veldhoen
    Division of Molecular Immunology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW71AA, UK
    Nature 453:106-9. 2008
  4. ncbi Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta
    G G Kuiper
    Center for Biotechnology and Department of Medical Nutrition, Karolinska Institute, Huddinge, Sweden
    Endocrinology 139:4252-63. 1998
  5. pmc Role of environmental chemicals in diabetes and obesity: a National Toxicology Program workshop review
    Kristina A Thayer
    Division of the National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA
    Environ Health Perspect 120:779-89. 2012
  6. pmc Environmental chemicals in pregnant women in the United States: NHANES 2003-2004
    Tracey J Woodruff
    Program on Reproductive Health and the Environment, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, Oakland, California 94612, USA
    Environ Health Perspect 119:878-85. 2011
  7. ncbi Association of urinary bisphenol A concentration with medical disorders and laboratory abnormalities in adults
    Iain A Lang
    Epidemiology and Public Health Group, Peninsula Medical School, Barrack Rd, Exeter EX2 5DW, UK
    JAMA 300:1303-10. 2008
  8. ncbi Current status of cadmium as an environmental health problem
    Lars Jarup
    Department of Epidemiology and Public Health, Imperial College London, London, UK
    Toxicol Appl Pharmacol 238:201-8. 2009
  9. ncbi Endocrine disruptors: from endocrine to metabolic disruption
    Cristina Casals-Casas
    Center for Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne, Switzerland
    Annu Rev Physiol 73:135-62. 2011
  10. ncbi Hazards of heavy metal contamination
    Lars Jarup
    Department of Epidemiology and Public Health, Imperial College, London, UK
    Br Med Bull 68:167-82. 2003

Detail Information

Publications343 found, 100 shown here

  1. pmc Exposure of the U.S. population to bisphenol A and 4-tertiary-octylphenol: 2003-2004
    Antonia M Calafat
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Environ Health Perspect 116:39-44. 2008
    ..Bisphenol A (BPA) and 4-tertiary-octylphenol (tOP) are industrial chemicals used in the manufacture of polycarbonate plastics and epoxy resins (BPA) and nonionic surfactants (tOP). These products are in widespread use in the United States...
  2. ncbi Epigenetic transgenerational actions of endocrine disruptors and male fertility
    Matthew D Anway
    Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, WA 99164 4231, USA
    Science 308:1466-9. 2005
    ..The ability of an environmental factor (for example, endocrine disruptor) to reprogram the germ line and to promote a transgenerational disease state has significant implications for evolutionary biology and disease etiology...
  3. ncbi The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins
    Marc Veldhoen
    Division of Molecular Immunology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW71AA, UK
    Nature 453:106-9. 2008
    ..AHR ligands may therefore represent co-factors in the development of autoimmune diseases...
  4. ncbi Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta
    G G Kuiper
    Center for Biotechnology and Department of Medical Nutrition, Karolinska Institute, Huddinge, Sweden
    Endocrinology 139:4252-63. 1998
    ....
  5. pmc Role of environmental chemicals in diabetes and obesity: a National Toxicology Program workshop review
    Kristina A Thayer
    Division of the National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA
    Environ Health Perspect 120:779-89. 2012
    ....
  6. pmc Environmental chemicals in pregnant women in the United States: NHANES 2003-2004
    Tracey J Woodruff
    Program on Reproductive Health and the Environment, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, Oakland, California 94612, USA
    Environ Health Perspect 119:878-85. 2011
    ....
  7. ncbi Association of urinary bisphenol A concentration with medical disorders and laboratory abnormalities in adults
    Iain A Lang
    Epidemiology and Public Health Group, Peninsula Medical School, Barrack Rd, Exeter EX2 5DW, UK
    JAMA 300:1303-10. 2008
    ..Bisphenol A (BPA) is widely used in epoxy resins lining food and beverage containers. Evidence of effects in animals has generated concern over low-level chronic exposures in humans...
  8. ncbi Current status of cadmium as an environmental health problem
    Lars Jarup
    Department of Epidemiology and Public Health, Imperial College London, London, UK
    Toxicol Appl Pharmacol 238:201-8. 2009
    ..Therefore, measures should be put in place to reduce exposure to a minimum, and the tolerably daily intake should be set in accordance with recent findings...
  9. ncbi Endocrine disruptors: from endocrine to metabolic disruption
    Cristina Casals-Casas
    Center for Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne, Switzerland
    Annu Rev Physiol 73:135-62. 2011
    ..Finally, we discuss the difficulties of fairly assessing the risks linked to EDC exposure, including developmental exposure, problems of high- and low-dose exposure, and the complexity of current chemical environments...
  10. ncbi Hazards of heavy metal contamination
    Lars Jarup
    Department of Epidemiology and Public Health, Imperial College, London, UK
    Br Med Bull 68:167-82. 2003
    ..Occupational exposure to arsenic, primarily by inhalation, is causally associated with lung cancer. Clear exposure-response relationships and high risks have been observed...
  11. ncbi High prevalence of prediabetes and diabetes in a population exposed to high levels of an organochlorine cocktail
    J Ukropec
    Diabetes Laboratory, Institute of Experimental Endocrinology an EU Centre of Excellence Slovak Academy of Sciences, Vlarska 3, 83306 Bratislava, Slovak Republic
    Diabetologia 53:899-906. 2010
    ..A heavily polluted area of Eastern Slovakia was targeted by the PCBRISK cross-sectional survey to search for possible links between environmental pollution and both prediabetes and diabetes...
  12. pmc Epidemiologic evaluation of measurement data in the presence of detection limits
    Jay H Lubin
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
    Environ Health Perspect 112:1691-6. 2004
    ..We illustrate various approaches using measurements of pesticide residues in carpet dust in control subjects from a case-control study of non-Hodgkin lymphoma...
  13. pmc Prenatal phenol and phthalate exposures and birth outcomes
    Mary S Wolff
    Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Environ Health Perspect 116:1092-7. 2008
    ..Many phthalates and phenols are hormonally active and are suspected to alter the course of development...
  14. pmc Birth weight and prenatal exposure to polychlorinated biphenyls (PCBs) and dichlorodiphenyldichloroethylene (DDE): a meta-analysis within 12 European Birth Cohorts
    Eva Govarts
    Environmental Risk and Health, Flemish Institute for Technological Research VITO, Mol, Belgium
    Environ Health Perspect 120:162-70. 2012
    ....
  15. pmc Urinary bisphenol A and obesity: NHANES 2003-2006
    Jenny L Carwile
    Department of Epidemiology, Harvard School of Public Health, 677 Huntington Ave, Boston, MA 02115, USA
    Environ Res 111:825-30. 2011
    ..We hypothesized that urinary BPA concentrations would be positively associated with general and central obesity...
  16. ncbi Assessing exposure to phthalates - the human biomonitoring approach
    Matthias Wittassek
    Chromsystems Instruments and Chemicals GmbH, Munich, Germany
    Mol Nutr Food Res 55:7-31. 2011
    ..Recent findings from animal studies suggest that a cumulative risk assessment for phthalates is warranted, and a cumulative exposure assessment to phthalates via human biomonitoring is a major step into this direction...
  17. pmc The E-SCREEN assay as a tool to identify estrogens: an update on estrogenic environmental pollutants
    A M Soto
    Tufts University School of Medicine, Department of Anatomy and Cellular Biology, Boston, MA 02111, USA
    Environ Health Perspect 103:113-22. 1995
    ....
  18. pmc Association of urinary phthalate metabolite concentrations with body mass index and waist circumference: a cross-sectional study of NHANES data, 1999-2002
    Elizabeth E Hatch
    Department of Epidemiology, Boston University School of Public Health, 715 Albany St, Boston, MA 02118, USA
    Environ Health 7:27. 2008
    ..Although diet and activity are key factors in the obesity epidemic, laboratory studies suggest that endocrine disrupting chemicals may also affect obesity...
  19. pmc Environmental causes of cancer: endocrine disruptors as carcinogens
    Ana M Soto
    Department of Anatomy and Cellular Biology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA
    Nat Rev Endocrinol 6:363-70. 2010
    ..Regardless, the data already amassed highlight the need for a public policy to reduce exposure to EDCs...
  20. pmc Epidemiologic evidence on the health effects of perfluorooctanoic acid (PFOA)
    Kyle Steenland
    Rollins School of Public Health, Emory University, Atlanta, Georgia, USA
    Environ Health Perspect 118:1100-8. 2010
    ..OBJECTIVE AND SOURCES: We reviewed the epidemiologic literature for PFOA...
  21. pmc Environmental health disparities: a framework integrating psychosocial and environmental concepts
    Gilbert C Gee
    University of Michigan School of Public Health, Department of Health Behavior and Health Education, Ann Arbor, Michigan, USA
    Environ Health Perspect 112:1645-53. 2004
    ..When not counterbalanced by resources, stressors may lead to heightened vulnerability to environmental hazards...
  22. pmc Interactions between chemical and climate stressors: a role for mechanistic toxicology in assessing climate change risks
    Michael J Hooper
    U S Geological Survey, Columbia Environmental Research Center, Columbia, MO, USA
    Environ Toxicol Chem 32:32-48. 2013
    ....
  23. pmc Lead exposure and cardiovascular disease--a systematic review
    Ana Navas-Acien
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    Environ Health Perspect 115:472-82. 2007
    ..This systematic review evaluates the evidence on the association between lead exposure and cardiovascular end points in human populations...
  24. pmc Variability of urinary concentrations of bisphenol A in spot samples, first morning voids, and 24-hour collections
    Xiaoyun Ye
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Environ Health Perspect 119:983-8. 2011
    ..Therefore, there is considerable within-person and between-person variability of BPA concentrations in spot urine samples. However, no information exists on the within-day variability of urinary BPA concentrations...
  25. pmc Low dose organochlorine pesticides and polychlorinated biphenyls predict obesity, dyslipidemia, and insulin resistance among people free of diabetes
    Duk Hee Lee
    Department of Preventative Medicine, School of Medicine, Kyungpook National University, Daegu, Korea
    PLoS ONE 6:e15977. 2011
    ..The current study examined if low dose POPs predicted future adiposity, dyslipidemia, and insulin resistance among controls without diabetes in that study...
  26. pmc Similarity of bisphenol A pharmacokinetics in rhesus monkeys and mice: relevance for human exposure
    Julia A Taylor
    Division of Biological Sciences, University of Missouri Columbia, Columbia, Missouri 65211, USA
    Environ Health Perspect 119:422-30. 2011
    ..We measured unconjugated and conjugated BPA levels in serum from adult female rhesus monkeys and adult female mice after oral administration of BPA and compared findings in mice and monkeys with prior published data in women...
  27. ncbi Impact of environmental endocrine disrupting chemicals on the development of obesity
    Retha R Newbold
    Developmental Endocrinology and Endocrine Disruptor Section, Laboratory of Molecular Toxicology, and National Toxicology Program, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, North Carolina 27713, USA
    Hormones (Athens) 9:206-17. 2010
    ..Potential mechanisms are summarized and future research needs are discussed...
  28. pmc Tubular and glomerular kidney effects in Swedish women with low environmental cadmium exposure
    Agneta Akesson
    Institute of Environmental Medicine, Division of Metals and Health, Karolinska Institutet, Stockholm, Sweden
    Environ Health Perspect 113:1627-31. 2005
    ..Although the effects were small, they may represent early signs of adverse effects, affecting large segments of the population. Subjects with diabetes seem to be at increased risk...
  29. pmc Prenatal exposure to PBDEs and neurodevelopment
    Julie B Herbstman
    Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, Columbia Center for Children s Environmental Health, New York, New York 10032, USA
    Environ Health Perspect 118:712-9. 2010
    ..Animal studies suggest that prenatal PBDE exposure may result in adverse neurodevelopmental effects...
  30. ncbi Toxic metals and oxidative stress part I: mechanisms involved in metal-induced oxidative damage
    N Ercal
    University of Missouri Rolla, Department of Chemistry, 65409 0010, USA
    Curr Top Med Chem 1:529-39. 2001
    ..In order to prove the importance of using antioxidants in heavy metal poisoning, pertinent biochemical mechanisms for metal-induced oxidative stress should be reviewed...
  31. pmc Environmental estrogens and obesity
    Retha R Newbold
    Developmental Endocrinology and Endocrine Disruptor Section, Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC 27709, United States
    Mol Cell Endocrinol 304:84-9. 2009
    ....
  32. pmc Persistent organic pollutant exposure leads to insulin resistance syndrome
    Jérôme Ruzzin
    National Institute of Nutrition and Seafood Research NIFES, Bergen, Norway
    Environ Health Perspect 118:465-71. 2010
    ..However, experimental evidence demonstrating a causal link between POPs and the development of insulin resistance is lacking...
  33. ncbi Role of nutrition and environmental endocrine disrupting chemicals during the perinatal period on the aetiology of obesity
    Jerrold J Heindel
    Division of Extramural Research and Training, National Institute of Environmental Health Sciences, NIH DHHS, Cellular, Organs and Systems Pathobiology Branch, Research Triangle Park, NC 27709, USA
    Mol Cell Endocrinol 304:90-6. 2009
    ..Eliminating exposures to these chemicals and improving nutrition during development offer the potential for reducing obesity and associated diseases...
  34. ncbi Cadmium carcinogenesis
    Michael P Waalkes
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Institute of Environmental Health Sciences, Triangle Park, NC 27706, USA
    Mutat Res 533:107-20. 2003
    ..Most studies indicate cadmium is poorly mutagenic and probably acts through indirect or epigenetic mechanisms, potentially including aberrant activation of oncogenes and suppression of apoptosis...
  35. ncbi Environmental pollutants and type 2 diabetes: a review of mechanisms that can disrupt beta cell function
    T L M Hectors
    Department of Biology, Laboratory of Ecophysiology, Biochemistry and Toxicology, University of Antwerp, Groenenborgerlaan 171, 2020 Antwerp, Belgium
    Diabetologia 54:1273-90. 2011
    ..are commonly accepted reasons for the occurrence of type 2 diabetes, it has recently been suggested that environmental pollutants are additional risk factors for diabetes development and this review aims to give an overview of the ..
  36. pmc Retrospective exposure estimation and predicted versus observed serum perfluorooctanoic acid concentrations for participants in the C8 Health Project
    Hyeong Moo Shin
    School of Social Ecology, University of California, Irvine, California 95616, USA
    Environ Health Perspect 119:1760-5. 2011
    ..People living or working in eastern Ohio and western West Virginia have been exposed to perfluorooctanoic acid (PFOA) released by DuPont Washington Works facilities...
  37. pmc Outbreak of fatal childhood lead poisoning related to artisanal gold mining in northwestern Nigeria, 2010
    Carrie A Dooyema
    Healthy Homes and Lead Poisoning Prevention Branch, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Environ Health Perspect 120:601-7. 2012
    ..In May 2010, a team of national and international organizations was assembled to investigate children's deaths due to lead poisoning in villages in northwestern Nigeria...
  38. pmc The estrogenic endocrine disrupting chemical bisphenol A (BPA) and obesity
    Frederick S vom Saal
    Division of Biological Sciences, University of Missouri Columbia, Columbia, MO 65211, USA
    Mol Cell Endocrinol 354:74-84. 2012
    ....
  39. ncbi Obesity and persistent organic pollutants: possible obesogenic effect of organochlorine pesticides and polychlorinated biphenyls
    Eveline Dirinck
    Department of Endocrinology, Diabetology and Clinical Pharmacology, Antwerp University Hospital and University of Antwerp, Antwerp, Belgium
    Obesity (Silver Spring) 19:709-14. 2011
    ..Combined, these results suggest that the diabetogenic effect of low-dose exposure to POPs might be more complicated than a simple obesogenic effect...
  40. pmc Chemical genomics profiling of environmental chemical modulation of human nuclear receptors
    Ruili Huang
    National Institutes of Health Chemical Genomics Center, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 3370, USA
    Environ Health Perspect 119:1142-8. 2011
    ....
  41. pmc Maternal cadmium exposure during pregnancy and size at birth: a prospective cohort study
    Maria Kippler
    Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Environ Health Perspect 120:284-9. 2012
    ..Cadmium (Cd) is an embryotoxic and teratogenic metal in a variety of animal species, but data from humans are limited...
  42. pmc Variability over 1 week in the urinary concentrations of metabolites of diethyl phthalate and di(2-ethylhexyl) phthalate among eight adults: an observational study
    James L Preau
    National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Environ Health Perspect 118:1748-54. 2010
    ..Several reports suggest that concentrations of phthalate metabolites in a spot urine sample can provide a reliable estimation of exposure to phthalates for up to several months...
  43. ncbi Global distribution of perfluorooctane sulfonate in wildlife
    J P Giesy
    Department of Zoology, National Food Safety and Toxicology Center, Institute for Environmental Toxicology, Michigan State University, East Lansing 48824, USA
    Environ Sci Technol 35:1339-42. 2001
    ..Currently available data indicate that the concentrations of PFOS in wildlife are less than those required to cause adverse effects in laboratory animals...
  44. pmc Bisphenol A impairs the double-strand break repair machinery in the germline and causes chromosome abnormalities
    Patrick Allard
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 107:20405-10. 2010
    ..C. elegans therefore constitutes a model of remarkable relevance to mammals with which to assess how our chemical landscape affects germ cells and meiosis...
  45. ncbi Phthalate exposure in pregnant women and their children in central Taiwan
    Susana Lin
    National Health Research Institutes, Taiwan
    Chemosphere 82:947-55. 2011
    ..The level of phthalate metabolites in milk and cord blood were comparable to those found in other populations. Further studies of health effects related to DEHP and DiNP exposure are necessary for the children...
  46. pmc Perinatal exposure to bisphenol a alters early adipogenesis in the rat
    Emmanuel Somm
    Faculty of Medicine, University of Geneva, Geneva, Switzerland
    Environ Health Perspect 117:1549-55. 2009
    ..The causes of the current obesity pandemic have not been fully elucidated. Implication of environmental endocrine disruptors such as bisphenol A (BPA) on adipose tissue development has been poorly investigated...
  47. pmc The applicability of biomonitoring data for perfluorooctanesulfonate to the environmental public health continuum
    John L Butenhoff
    3M Company, Medical Department, St Paul, Minnesota 55144, USA
    Environ Health Perspect 114:1776-82. 2006
    ....
  48. pmc Global DNA hypomethylation is associated with high serum-persistent organic pollutants in Greenlandic Inuit
    Jennifer A Rusiecki
    Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
    Environ Health Perspect 116:1547-52. 2008
    ..DNA methylation, an epigenetic mechanism, has been associated with cancer initiation and progression. Greenlandic Inuit have some of the highest reported POP levels worldwide...
  49. ncbi Reproductive toxicity of phthalate esters
    Anderson Joel Martino-Andrade
    Universidade Federal do Parana, Departamento de Fisiologia, Curitiba, Brazil
    Mol Nutr Food Res 54:148-57. 2010
    ..Finally, we point out some critical issues that should be addressed in order to clarify the implications of phthalates for human reproduction...
  50. ncbi Modes of action in ecotoxicology: their role in body burdens, species sensitivity, QSARs, and mixture effects
    Beate I Escher
    Swiss Federal Institute for Environmental Science and Technology EAWAG, Dubendorf
    Environ Sci Technol 36:4201-17. 2002
    ....
  51. ncbi Twenty-four hour human urine and serum profiles of bisphenol a during high-dietary exposure
    Justin G Teeguarden
    Fundamental and Computational Sciences, Pacific Northwest National Laboratory, Richland, Washington 99352, USA
    Toxicol Sci 123:48-57. 2011
    ..During these high dietary exposures, (TOT)BPA concentrations in serum were undetectable in 83% of the 320 samples collected and BPA concentrations were determined to be less than or equal to LOD in all samples...
  52. pmc Prenatal exposure to perfluorooctanoate and risk of overweight at 20 years of age: a prospective cohort study
    Thorhallur I Halldorsson
    Center for Fetal Programming, Department of Epidemiology Research, Statens Serum Institute, Copenhagen, Denmark
    Environ Health Perspect 120:668-73. 2012
    ..A recent study on low-dose developmental exposure to PFOA in mice reported increased weight and elevated biomarkers of adiposity in postpubertal female offspring...
  53. ncbi Molecular biomarkers of oxidative stress in aquatic organisms in relation to toxic environmental pollutants
    Athanasios Valavanidis
    Laboratory of Organic Chemistry, Department of Chemistry, Free Radical Research Group, University of Athens, University Campus Zografou, 15771 Athens, Greece
    Ecotoxicol Environ Saf 64:178-89. 2006
    ..The balance between prooxidant endogenous and exogenous factors (i.e., environmental pollutants) and antioxidant defenses (enzymatic and nonenzymatic) in biological systems can be used to assess toxic ..
  54. pmc Endocrine disrupting chemicals and disease susceptibility
    Thaddeus T Schug
    National Institute of Environmental Health Sciences, Division of Extramural Research and Training, Cellular, Organ and Systems Pathobiology Branch, Research Triangle Park, NC 27709, USA
    J Steroid Biochem Mol Biol 127:204-15. 2011
    ..This review focuses on the mechanisms and modes of action by which EDCs alter hormone signaling. It also includes brief overviews of select disease endpoints associated with endocrine disruption...
  55. pmc Organophosphate pesticide exposure and attention in young Mexican-American children: the CHAMACOS study
    Amy R Marks
    Center for Children s Environmental Health Research, School of Public Health, University of California, Berkeley, Berkeley, California 94720, USA
    Environ Health Perspect 118:1768-74. 2010
    ..Exposure to organophosphate (OP) pesticides, well-known neurotoxicants, has been associated with neurobehavioral deficits in children...
  56. pmc Food packaging and bisphenol A and bis(2-ethyhexyl) phthalate exposure: findings from a dietary intervention
    Ruthann A Rudel
    Silent Spring Institute, Newton, Massachusetts 02458, USA
    Environ Health Perspect 119:914-20. 2011
    ..They have been associated with endocrine disruption in animals and in some human studies. Human exposure sources have been estimated, but the relative contribution of dietary exposure to total intake has not been studied empirically...
  57. ncbi Toxicity testing in the 21st century: a vision and a strategy
    Daniel Krewski
    R Samuel McLaughlin Centre for Population Health Risk Assessment, Institute of Population Health, University of Ottawa, Ottawa, Ontario, Canada
    J Toxicol Environ Health B Crit Rev 13:51-138. 2010
    ..Implementation of these strategies would result in a new toxicity testing paradigm firmly based on human biology...
  58. pmc Environmental phthalate exposure in relation to reproductive outcomes and other health endpoints in humans
    Shanna H Swan
    Department of Obstetrics and Gynecology, School of Medicine and Dentistry, University of Rochester, 601 Elmwood Avenue, Box 668, Rochester, NY 14642, USA
    Environ Res 108:177-84. 2008
    ..Replication of the results described here and further mechanistic studies are needed to strengthen links between phthalates and adverse health outcomes...
  59. pmc Endocrine disrupters as obesogens
    Felix Grün
    Department of Developmental and Cell Biology, University of California Irvine, 92697 2300, USA
    Mol Cell Endocrinol 304:19-29. 2009
    ..This review highlights recent advances in our understanding of the molecular targets and mechanisms of action for these compounds and areas of future research needed to evaluate the significance of their contribution to obesity...
  60. pmc Variability and predictors of urinary bisphenol A concentrations during pregnancy
    Joe M Braun
    Department of Environmental Health, Harvard University, Boston, Massachusetts, USA
    Environ Health Perspect 119:131-7. 2011
    ..Prenatal bisphenol A (BPA) exposure may be associated with developmental toxicity, but few studies have examined the variability and predictors of urinary BPA concentrations during pregnancy...
  61. pmc Urinary phthalate metabolite concentrations and diabetes among women in the National Health and Nutrition Examination Survey (NHANES) 2001-2008
    Tamarra James-Todd
    Brigham and Women s Hospital and Harvard Medical School, 1620 Tremont St, Division of Women s Health, 3rd Floor, Boston, MA 02120, USA
    Environ Health Perspect 120:1307-13. 2012
    ..Few studies have evaluated the association between phthalate metabolites, diabetes, and diabetes-related risk factors among women...
  62. pmc The influence of global climate change on the scientific foundations and applications of Environmental Toxicology and Chemistry: introduction to a SETAC international workshop
    Ralph G Stahl
    DuPont, Wilmington, DE, USA
    Environ Toxicol Chem 32:13-9. 2013
    ....
  63. pmc Ecological risk assessment in the context of global climate change
    Wayne G Landis
    Western Washington University, Institute of Environmental Toxicology, Bellingham, WA, USA
    Environ Toxicol Chem 32:79-92. 2013
    ..Good communication is essential for making risk-related information understandable and useful for managers and stakeholders to implement a successful risk-assessment and decision-making process...
  64. pmc Influence of global climate change on chemical fate and bioaccumulation: the role of multimedia models
    Todd Gouin
    Unilever, Safety and Environmental Assurance Centre, Colworth Science Park, Sharnbrook, United Kingdom
    Environ Toxicol Chem 32:20-31. 2013
    ....
  65. pmc Intrinsic human elimination half-lives of polychlorinated biphenyls derived from the temporal evolution of cross-sectional biomonitoring data from the United Kingdom
    Roland Ritter
    Safety and Environmental Technology Group, ETH Zurich, Zurich, Switzerland
    Environ Health Perspect 119:225-31. 2011
    ..However, estimates of intrinsic elimination at background levels are required for risk assessments for the general population...
  66. pmc Influence of prenatal lead exposure on genomic methylation of cord blood DNA
    J Richard Pilsner
    Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA
    Environ Health Perspect 117:1466-71. 2009
    ..Epigenetic fetal programming via DNA methylation may provide a pathway by which environmental lead exposure can influence disease susceptibility...
  67. pmc Childhood obesity and environmental chemicals
    Michele La Merrill
    Mount Sinai School of Medicine, New York, NY, USA
    Mt Sinai J Med 78:22-48. 2011
    ..Recommendations for future epidemiologic and experimental research on the chemical origins of obesity are also given...
  68. ncbi Polybrominated diphenyl ethers as endocrine disruptors of adipocyte metabolism
    Andrea A Hoppe
    Department of Animal and Nutritional Sciences, University of New Hampshire, Kendall Hall, 129 Main St, Durham, NH 03824, USA
    Obesity (Silver Spring) 15:2942-50. 2007
    ..We tested the hypothesis that a class of lipid-soluble flame retardant chemicals known to accumulate in adipose tissue, polybrominated diphenyl ethers (PBDEs), disrupts insulin and isoproterenol sensitivity of isolated rat adipocytes...
  69. pmc Prenatal organochlorine exposure and behaviors associated with attention deficit hyperactivity disorder in school-aged children
    Sharon K Sagiv
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Epidemiol 171:593-601. 2010
    ..76, 95% confidence interval: 1.06, 2.92) and a similar relation for p,p'-DDE. These results support an association between low-level prenatal organochlorine exposure and ADHD-like behaviors in childhood...
  70. ncbi Fish consumption in pregnancy, cord blood mercury level and cognitive and psychomotor development of infants followed over the first three years of life: Krakow epidemiologic study
    Wieslaw Jedrychowski
    Epidemiology and Preventive Medicine, Coll Med Jagiellonian University in Krakow, Poland
    Environ Int 33:1057-62. 2007
    ..Although the maternal fish consumption is supposed to have beneficial effects on development of infants, it may be harmful for child cognitive development since fish is a common source of methylmercury...
  71. ncbi Emerging endocrine disrupters: perfluoroalkylated substances
    Allan Astrup Jensen
    FORCE Technology, Broendby, Denmark
    Int J Androl 31:161-9. 2008
    ..However, hundreds of related chemicals: homologues with shorter or longer alkyl chain, PFOA and telomers, which potentially may degrade to perfluoroalkanoic (carboxylic) acids, are not regulated...
  72. ncbi Exposure to phthalates: reproductive outcome and children health. A review of epidemiological studies
    Joanna Jurewicz
    Department of Environmental Epidemiology, Nofer Institute of Occupational Medicine, Łódź, Poland
    Int J Occup Med Environ Health 24:115-41. 2011
    ..Considering the suggested health effects, more epidemiologic data is urgently needed and, in the meantime, precautionary policies must be implemented...
  73. pmc Human body burdens of chemicals used in plastic manufacture
    Holger M Koch
    BGFA Research Institute of Occupational Medicine, German Social Accident Insurance, Ruhr University Bochum, Bochum, Germany
    Philos Trans R Soc Lond B Biol Sci 364:2063-78. 2009
    ..We discuss several factors relevant for interpreting and understanding biomonitoring data, including selection of both biomarkers of exposure and human matrices, and toxicokinetic information...
  74. pmc Association between type 2 diabetes and exposure to persistent organic pollutants
    Riikka Airaksinen
    Department of Environmental Health, National Institute for Health and Welfare, Kuopio, Finland
    Diabetes Care 34:1972-9. 2011
    ..The purpose of this cross-sectional study is to examine the association between type 2 diabetes and POP exposure in the Helsinki Birth Cohort Study...
  75. ncbi Cross-induction of detoxification genes by environmental xenobiotics and insecticides in the mosquito Aedes aegypti: impact on larval tolerance to chemical insecticides
    Rodolphe Poupardin
    Laboratoire d Ecologie Alpine, UMR CNRS Université Joseph Fourier 5553, Equipe Perturbations Environnementales et Xénobiotiques, Domaine Universitaire de Saint Martin d Hères 2233, rue de la piscine Bât D Biologie, BP 53, 38041 Grenoble Cedex 9, France
    Insect Biochem Mol Biol 38:540-51. 2008
    ..Molecular mechanisms involved and impact on mosquito control strategies are discussed...
  76. pmc Relation between cord blood mercury levels and early child development in a World Trade Center cohort
    Sally Ann Lederman
    Columbia Center for Children s Environmental Health, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
    Environ Health Perspect 116:1085-91. 2008
    ..This study was designed to determine whether prenatal mercury exposure, including potential releases from the World Trade Center (WTC) disaster, adversely affects fetal growth and child development...
  77. pmc Partition of environmental chemicals between maternal and fetal blood and tissues
    Larry L Needham
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Environ Sci Technol 45:1121-6. 2011
    ..Although the environmental chemicals examined pass through the placenta and are excreted into milk, partitions between maternal and fetal samples are not uniform...
  78. ncbi Strong associations between low-dose organochlorine pesticides and type 2 diabetes in Korea
    H K Son
    Department of Preventive Medicine, Kyungpook National University, Jung Gu, Daegu, South Korea
    Environ Int 36:410-4. 2010
    ..Asians may be more susceptible to adverse effects of OC pesticides than other races...
  79. pmc Intrauterine exposure to environmental pollutants and body mass index during the first 3 years of life
    Stijn L Verhulst
    Department of Pediatrics, University of Antwerp, Antwerp, Belgium
    Environ Health Perspect 117:122-6. 2009
    ..We investigated the association between body mass index (BMI) standard deviation score (SDS) and prenatal exposure to hexachlorobenzene, dichlorodiphenyldichloroethylene (DDE), dioxin-like compounds, and polychlorinated biphenyls (PCBs)...
  80. ncbi Accumulation of cadmium in human placenta interacts with the transport of micronutrients to the fetus
    Maria Kippler
    Institute of Environmental Medicine, Division of Metals and Health, Karolinska Institutet, Stockholm, Sweden
    Toxicol Lett 192:162-8. 2010
    ..In conclusion, the Cd concentrations in placenta were clearly elevated, which seemed to impair Zn transfer to the fetus. Induction of MT explained the placental accumulation of Cd, but not the impairment of Zn transport...
  81. pmc Maternal arsenic exposure and impaired glucose tolerance during pregnancy
    Adrienne S Ettinger
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02215, USA
    Environ Health Perspect 117:1059-64. 2009
    ..Accumulating evidence has shown an increased risk of type 2 diabetes in general populations exposed to arsenic, but little is known about exposures during pregnancy and the association with gestational diabetes (GD)...
  82. ncbi Burden of cadmium in early childhood: longitudinal assessment of urinary cadmium in rural Bangladesh
    Maria Kippler
    Institute of Environmental Medicine, Karolinska Institutet, Box 210, SE 17177 Stockholm, Sweden
    Toxicol Lett 198:20-5. 2010
    ..Urinary cadmium concentrations were particularly elevated at 3 months of age, indicating limited reabsorption and accumulation of cadmium in the kidneys, known to be the main site of cadmium burden in older children and adults...
  83. ncbi Environmental pollutants and the thyroid
    Elizabeth N Pearce
    Section of Endocrinology, Diabetes, and Nutrition, Boston University Medical Center, 88 East Newton Street, Evans 201, Boston, MA 02118, USA
    Best Pract Res Clin Endocrinol Metab 23:801-13. 2009
    ..Organochlorine pesticides and dioxins may decrease serum T(4) half-life by activating hepatic enzymes. Additional studies are needed to further elucidate the risk posed by these and other potentially thyroid-disrupting compounds...
  84. pmc Prevalence of metabolic syndrome associated with body burden levels of dioxin and related compounds among Japan's general population
    Hirokazu Uemura
    Department of Preventive Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
    Environ Health Perspect 117:568-73. 2009
    ..Environmental exposure to some persistent organic pollutants has been reported to be associated with a metabolic syndrome in the U.S. population...
  85. pmc In vitro screening of environmental chemicals for targeted testing prioritization: the ToxCast project
    Richard S Judson
    National Center for Computational Toxicology, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Environ Health Perspect 118:485-92. 2010
    ..The U.S. Environmental Protection Agency's ToxCast program aims to address these concerns by screening and prioritizing chemicals for potential human toxicity using in vitro assays and in silico approaches...
  86. pmc Minding the calcium store: Ryanodine receptor activation as a convergent mechanism of PCB toxicity
    Isaac N Pessah
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    Pharmacol Ther 125:260-85. 2010
    ....
  87. ncbi Internal phthalate exposure over the last two decades--a retrospective human biomonitoring study
    Matthias Wittassek
    Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, University of Erlangen Nuremberg, Germany
    Int J Hyg Environ Health 210:319-33. 2007
    ....
  88. pmc Cadmium exposure and hypertension in the 1999-2004 National Health and Nutrition Examination Survey (NHANES)
    Maria Tellez-Plaza
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe St, Rm W7033B, Baltimore, MD 21205, USA
    Environ Health Perspect 116:51-6. 2008
    ..Cadmium induces hypertension in animal models. Epidemiologic studies of cadmium exposure and hypertension, however, have been inconsistent...
  89. ncbi GerES IV: phthalate metabolites and bisphenol A in urine of German children
    Kerstin Becker
    Federal Environment Agency UBA, Dessau Rosslau Berlin, Germany
    Int J Hyg Environ Health 212:685-92. 2009
    ..7microg/l. A rough calculation of the daily intakes on the basis of the measured concentrations in urine resulted in daily intakes two orders of magnitude lower than the current EFSA reference dose of 50microg/kgbw/d...
  90. pmc Serum polybrominated diphenyl ether (PBDE) levels are higher in children (2-5 years of age) than in infants and adults
    Leisa Maree L Toms
    University of Queensland, National Research Centre for Environmental Toxicology, 39 Kessels Road, Coopers Plains, Queensland 4108, Australia
    Environ Health Perspect 117:1461-5. 2009
    ..Polybrominated diphenyl ethers (PBDEs) are used as flame retardants in many products and have been detected in human samples worldwide. Limited data show that concentrations are elevated in young children...
  91. ncbi Tracking the pathways of human exposure to perfluorocarboxylates
    Robin Vestergren
    Department of Applied Environmental Science ITM, Stockholm University, Svante Arrhenius väg 8C, SE 10691 Stockholm, Sweden
    Environ Sci Technol 43:5565-75. 2009
    ..5-5.5 of the daily intakes derived from exposure media, which provides further supporting evidence that dietary exposure is a major ongoing exposure pathway of PFOA to the background population...
  92. ncbi An observational study of the potential exposures of preschool children to pentachlorophenol, bisphenol-A, and nonylphenol at home and daycare
    Nancy K Wilson
    Battelle Memorial Institute, 100 Capitola Drive, Suite 301, Durham, NC 27713 4411, USA
    Environ Res 103:9-20. 2007
    ....
  93. ncbi A review on environmental factors regulating arsenic methylation in humans
    Chin Hsiao Tseng
    National Taiwan University College of Medicine, Taipei, Taiwan
    Toxicol Appl Pharmacol 235:338-50. 2009
    ....
  94. ncbi Perinatal exposure to polychlorinated biphenyls differentially affects cerebellar development and motor functions in male and female rat neonates
    K Nguon
    Department of Psychiatry, Brigham and Women s Hospital, Boston, MA, USA
    Cerebellum 4:112-22. 2005
    ..Further studies of neonatal PCB exposure will establish whether the environmental pollutants can contribute to the sex-related preponderance of certain neuropsychiatric disorders.
  95. ncbi Decline in perfluorooctanesulfonate and other polyfluoroalkyl chemicals in American Red Cross adult blood donors, 2000-2006
    Geary W Olsen
    3M Company, Medical Department, St Paul, Minnesota, American Red Cross, North Central Region, St Paul, Minnesota, USA
    Environ Sci Technol 42:4989-95. 2008
    ..Direct and indirect exposure sources of PFOA could include historic and ongoing electrochemical cell fluorination (ECF) of PFOA, telomer production of PFOA, fluorotelomer-based precursors, and other fluoropoly-mer production...
  96. ncbi Induction of cytochrome P4501A1
    J P Whitlock
    Department of Molecular Pharmacology, Stanford University School of Medicine, California 94305 5332, USA
    Annu Rev Pharmacol Toxicol 39:103-25. 1999
    ....
  97. pmc Pesticides and Parkinson's disease--is there a link?
    Terry P Brown
    Medical Research Council Institute for Environment and Health, University of Leicester, Leicester, United Kingdom
    Environ Health Perspect 114:156-64. 2006
    ....
  98. pmc Bisphenol a exposure in Mexico City and risk of prematurity: a pilot nested case control study
    David Cantonwine
    Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan, USA
    Environ Health 9:62. 2010
    ....
  99. pmc Levels of hexachlorobenzene (HCB) in breast milk in relation to birth weight in a Norwegian cohort
    Merete Eggesbø
    Department of Genes and Environment, Division of Epidemiology, Norwegian Institute of Public Health, P O Box 4404, Nydalen, N 0403 Oslo, Norway
    Environ Res 109:559-66. 2009
    ..However, its potential for reproductive toxicity in humans exposed to background levels has not been fully evaluated. Here we examined the association between maternal levels of HCB and their infants' birth weight...
  100. ncbi Aggregate exposures of nine preschool children to persistent organic pollutants at day care and at home
    Nancy K Wilson
    Battelle Memorial Institute, Durham, NC 27713 4411, USA
    J Expo Anal Environ Epidemiol 13:187-202. 2003
    ..The children's potential aggregate doses, calculated from our data, were generally well below established reference doses (RfDs) for those compounds for which RfDs are available...
  101. ncbi Obesogens
    Felix Grün
    Center for Complex Biological Systems, University of California Irvine, Irvine, California 92697 2280, USA
    Curr Opin Endocrinol Diabetes Obes 17:453-9. 2010
    ..This review focuses on recent experimental advances for candidate obesogens that target nuclear hormone receptors when a direct link between exposure, modulation of transcriptional networks and adipogenic phenotypes can be rationalized...

Research Grants70

  1. ROLE OF CYTOKINE METABOLISM IN OZONE IMMUNOTOXICITY
    Judith Zelikoff; Fiscal Year: 2001
    ..Adapted from the Investigator's Abstract) The lungs are a major route for the introduction of environmental pollutants into the body...
  2. Ubiquitous pollutant acrolein inhibits IFN?? antiviral signaling: relevance to HC
    Swati Joshi-Barve; Fiscal Year: 2013
    ..of anti-HCV therapy, including obesity, diabetes, alcohol abuse, oxidative stress, cigarette smoking and environmental pollutants. Acrolein is a ubiquitous, highly reactive environmental and industrial pollutant, and is designated by ..
  3. The effect of trichloroethylene exposure on adverse pregnancy outcomes
    Iman Hassan; Fiscal Year: 2013
    ..Limited studies have explored the impact of exposure to environmental pollutants on pregnancy outcomes...
  4. Molecular Mechanism of Acrolein-Induced Vascular Toxicity: Role of PPAR gamma and
    Zivar Yousefipour; Fiscal Year: 2013
    ..due to lower socioeconomic status of the minorities and residence in areas with increased exposure to environmental pollutants. This study will broaden our understanding of contribution of environmental pollutants to CVD, and ..
  5. Genetic Determinants of Lung Injury
    Beverly H Koller; Fiscal Year: 2013
    ..oxidative stress are particularly important in the lung, because it is an important point of contact with environmental pollutants that can add significantly to the intrinsic ROS burden...
  6. The role of human DNA polymerase eta in the mutagenic response to oxidative stres
    SCOTT DAVID MCCULLOCH; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE Exposure to environmental pollutants and other agents causes oxidative stress, a condition that underlies many disease states including cancer ..
  7. Developing Nrf2 as a target for treatment of corticosteroid resistance in COPD
    Robert A Wise; Fiscal Year: 2012
    ..is frequently amplified during fhe periods of acute exacerbation caused by bacteria, virus and other environmental pollutants. Abnormal airway inflammation is thought to contribute to chronic bronchitis, small-airway obstruction ..
  8. Mitochondrial Biomarkers of Cardiomyopathy and Cure in Chagas Disease
    Nisha Jain Garg; Fiscal Year: 2013
    ..Importantly, the tools we will develop will be applicable to other chronic diseases where mitochondria plays a role (e.g., diabetes, Alzheimer, Parkinson, Huntington) and to testing the toxicity of environmental pollutants.
  9. Environment, Novel Aging Outcomes, and Genetics
    Sung Kyun Park; Fiscal Year: 2013
    ..the causes of age-related pathological changes is required, but little is known about the impacts of environmental pollutants on such age-related diseases...
  10. Environmental Triggers of Cardiometabolic Disease
    Sanjay Rajagopalan; Fiscal Year: 2013
    ..poor diet, exercise and genetics have been the primary suspects, the link between chronic exposure to environmental pollutants has only gained recent attention...
  11. Histone modifications and respiratory effects of traffic particle exposure
    Lifang Hou; Fiscal Year: 2013
    ..Exposure to environmental pollutants has been shown to induce histone modifications in vitro...
  12. Role of the Aryl Hydrocarbon Receptor in Lung Inflammation
    PATRICIA JANET SIME; Fiscal Year: 2012
    ..provided by applicant): Exposure of human beings to tobacco smoke, as well as to certain dusts and environmental pollutants, incites lung inflammation and in some cases causes cancer...
  13. Phthalate Exposure and Pregnancy Outcome
    T Peter Stein; Fiscal Year: 2010
    ..Risk is highest for low income minorities who may also have increased exposure to environmental pollutants like phthalate...
  14. Cellular Determinants of Ah Receptor Signaling
    Thomas R Sutter; Fiscal Year: 2013
    ..factor that mediates the toxic effects, including carcinogenicity and teratogenicity, of a large class of environmental pollutants known as 'dioxinlike'compounds, named after the most potent congener 2,3,7,8-tetrachlorodibenzo-..
  15. Human CYP1A1, diet and dioxin-induced hypertension
    Mary K Walker; Fiscal Year: 2012
    ..fish or fish oil supplements, many individuals avoid fish consumption due to concern about accumulated environmental pollutants. It is well known that halogenated aromatic hydrocarbon (HAH) pollutants bioaccumulate in fish and ..
  16. Investigating gene x environment interaction using human exposures to O3 & LPS
    David B Peden; Fiscal Year: 2010
    ..HEALTH RELEVANCE: Knowledge obtained from this research can be used for mitigation of the effect of environmental pollutants on persons with lung and cardiovascular disease through development of personal mitigation strategies and ..
  17. Impact of aryl hydrocarbon receptor ligand ingestion on gastrointestinal immunity
    Barbara Platzer; Fiscal Year: 2013
    ..This could be due in part to increased exposure to environmental pollutants and drugs, which target the AhR...
  18. Immunotoxicity in Humans with Lifetime Exposure to Ocean Pullutants
    PHILIPPE ADAM GRANDJEAN; Fiscal Year: 2013
    DESCRIPTION (provided by applicant) Seafood is a main source of human exposure to environmental pollutants, such as methyl mercury and lipophilic contaminants, including polychlorinated biphenyls (PCBs)...
  19. Transgenerational Inheritance of Epigenetic Effects of Polychlorinated Biphenyls
    Charles V Vorhees; Fiscal Year: 2013
    ..Successful demonstration of transgenerational inheritance in response to in utero PCB exposure will transform our understanding of the health effects of these ubiquitous environmental pollutants.
  20. Pharmacogenomics of Human P450 Oxidoreductase
    Walter L Miller; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Most drugs, xenobiotics and environmental pollutants that enter the human body are metabolized by P450 enzymes in the endoplasmic reticulum of liver cells...
  21. Pollutant-related diabetes in the Nurses'Health Study II
    Qi Sun; Fiscal Year: 2013
    ..Meanwhile, evidence now suggests that some environmental pollutants, especially the persistent organic pollutants (POPs), may also lead to increased risk of both obesity and ..
  22. Role of the Indoor Environment on Oxidative Stress Related Sinonasal Inflammation
    Murugappan Ramanathan; Fiscal Year: 2013
    ..Ramanathan has now transitioned his focus towards examining how the indoor environmental pollutants and allergens propagate oxidative stress related sinonasal inflammation...
  23. A novel approach for quantitation of N-terminal valine adducts
    Gunnar Boysen; Fiscal Year: 2012
    ..Humans are constantly exposed to various mixtures, such as tobacco smoke, auto exhaust, and other environmental pollutants, containing several thousand compounds, including many known carcinogens...
  24. Field-Deployable Monitor to Assess Personal Exposure to Multiple Heavy Metals
    BADAWI M DWEIK; Fiscal Year: 2010
    ..Heavy metals are significant environmental pollutants because they tend to persist, tend to bioaccumulate and can result in serious adverse health effects when ..
  25. Household air pollution in Tanzania, placental health and pregnancy outcome
    BLAIR JOHNSON WYLIE; Fiscal Year: 2013
    ..they will learn will be translatable to the evaluation of obstetric risks associated with additional environmental pollutants to which these women are co-exposed...
  26. Metabolic Impact of Fetal or Adult Exposure to Environmental Endocrine Disruptors
    Robert M Sargis; Fiscal Year: 2013
    ..these EDCs differentially modulate energy homeostasis under various metabolic stresses will add significantly to our understanding of the impact of environmental pollutants on the risk of metabolic diseases such as obesity and diabetes.
  27. Prophylactic Use of Vitamin E for Prevention of Occupational PAH-Induced Damage
    Debbie Mustacich; Fiscal Year: 2009
    ..applicant): Polycyclic aromatic hydrocarbons (PAHs), including benzo(a)pyrene (BP), form a major class of environmental pollutants suggested to be causative factors in a variety of disease susceptibilities, including cancer...
  28. Translesion DNA synthesis in humans
    Louise Prakash; Fiscal Year: 2012
    ..lesions are generated in human cells from cellular oxidative reactions and from exposure to a variety of environmental pollutants and carcinogens...
  29. The Nerve Terminal as the Site of Action for Type-2 Alkenes
    RICHARD MICHAEL LOPACHIN; Fiscal Year: 2013
    ..The type- 2 alkenes are prevalent dietary contaminants and environmental pollutants that have significant toxicological consequences...
  30. Neural stem cell susceptibility to ambient particulate matter over the lifespan
    Colleen Cosgrove Hegg; Fiscal Year: 2013
    ..Children are especially sensitive to environmental pollutants and the mechanisms for this increased susceptibility have not been elucidated...
  31. Susceptible Window of High Fat Diet/Bisphenol A Programming of Breast Cancer Risk
    Shuk Mei Ho; Fiscal Year: 2013
    ..research findings into public awareness and action to reduce the burden of adverse lifestyle choices and environmental pollutants on BCa risk through an outreach program that partners with the Pink Ribbon Girls...
  32. UC Davis California National Primate Research Center Respiratory Disease Center
    DALLAS MELVIN HYDE; Fiscal Year: 2010
    ..The RD Center will enable on-site and off-site researchers to further investigate the mechanisms by which environmental pollutants 1) alter prenatal and postnatal lung development;2) exacerbate house dust mite-induced asthma;and 3) ..
  33. Diabetes and Persistent Organic Pollutants
    MARY ELLEN TURYK; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: Project Narrative This investigation will study the effect of exposure to environmental pollutants on development of diabetes...
  34. Adaptive Evolutionary Responses of White-footed Mice (Peromyscus leucopus) to Urb
    Jason Munshi-South; Fiscal Year: 2012
    ..thrive in urban environments experience higher population densities, enhanced exposure to disease and environmental pollutants, and greater competition for limited resources...
  35. Role of Rev1 in error-free replication of DNA damage and in mutation prevention
    Satya Prakash; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: DNA lesions generated from cellular oxidative damage and from exposure to environmental pollutants affect the stability and integrity of genomic DNA...
  36. Identification of DNA aptazymes for small-molecule sensors
    Dana A Baum; Fiscal Year: 2012
    ..is to use the binding and catalytic abilities of DNA to develop new small- molecule sensors for environmental pollutants. The successful development of these sensors will provide individuals with new tools for monitoring their ..
  37. Macrophages and Inflammatory Mediators in Silica-Induced Carcinogenesis
    DEBRA LYNN LASKIN; Fiscal Year: 2012
    ..studies will provide new mechanistic clues about the pathways leading to the development of lung cancer and may suggest innovative therapeutic approaches for abrogating tissue injury associated with exposure to environmental pollutants.
  38. Exposure To Polycyclic Aromatic Hydrocarbons And Male Sperm Quality
    HUEIWANG ANNA COOK JENG; Fiscal Year: 2010
    ..and Male Sperm Quality Polycyclic aromatic hydrocarbons (PAHs) are one of the most ubiquitous environmental pollutants. Humans are constantly exposed to complex mixtures from a variety of sources...
  39. Symposium on Air Pollution and Cardiovascular Disease
    JOEL DANIEL KAUFMAN; Fiscal Year: 2010
    ..to collectively define the nature and the scope of the problem related to the cardiovascular effects of environmental pollutants. Although extensive epidemiological studies demonstrate a link between pollution and heart disease, it is ..
  40. Environmental Determinants of Cognitive Function and Decline in Older Adults
    Melinda Power; Fiscal Year: 2012
    ..However, few interventions have been identified to prevent or delay cognitive decline. Widespread environmental pollutants may be related to cognitive decline in later years through neurotoxic effects or adverse effects on ..
  41. Methylomic and genomic impacts of organic pollutants in Dup15q syndrome
    Janine M LaSalle; Fiscal Year: 2013
    ..studies are expected to formally test the hypothesis that DNA methylation levels reduced by specific environmental pollutants may result in genomic rearrangements and alterations in long-range chromatin, leading to transcriptional ..
  42. Epigenetic Interaction of MECP2 and Organic Pollutants in Neurodevelopment
    Janine LaSalle; Fiscal Year: 2009
    ..a combination of systems and approaches that focus on the central question of the impact of persistent environmental pollutants (POPs) on precise epigenetic changes that occur in neurodevelopmental disorders...
  43. Quantitative proteomic profiling of reactive cysteines in oxidative stress
    Chu Wang; Fiscal Year: 2012
    ..provided by applicant) When cells are subjected to oxidative stress during inflammation and exposure to environmental pollutants, such as nitrogen dioxide or ozone, peroxidation of membrane lipids yields several reactive end products, ..
  44. Training in Molecular Toxicology
    OLIVER NMN HANKINSON; Fiscal Year: 2013
    ..Others investigate the carcinogenic/mutagenic effects of these and other environmental pollutants. A new area for the program is the role of pesticides in the etiology of Parkinson's disease...
  45. Bayesian integration of biomarkers and spatial exposure data
    SCOTT MICHAEL BARTELL; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Many environmental pollutants have distinct patterns in both space and time...
  46. Role of human DNA polymerase kappa in replicative bypass of DNA lesions
    Satya Prakash; Fiscal Year: 2013
    ..the multi-cyclic benzo[a]pyrene 7,8-diol 9,10-epoxide (BPDE) N2-dG adduct that results from exposure to environmental pollutants and carcinogens...
  47. Genetic control of replication through DNA lesions in humans, and carcinogenesis
    Satya Prakash; Fiscal Year: 2013
    ..roles of a number of human TLS Pols in promoting replication through a variety of DNA lesions induced by environmental pollutants and carcinogens and by cellular oxidative damage...
  48. TRAINING IN NEUROENDOCRINOLOGY
    Geert J De Vries; Fiscal Year: 2010
    ..Neuroendocrinology can also explain how common environmental pollutants disrupt hormone-brain interactions, thereby causing, e.g...
  49. The Epigenetic Mechanism of Arsenic Lung Carcinogenesis - Role of MicroRNAs
    Chengfeng Yang; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Arsenic (As) is one of the most common environmental pollutants and exposure to As through drinking water is a major environmental health concern, affectsing millions of ..
  50. UDP-Glucuronosyltransferases in responses to environmental and endogenous toxins
    Beverly H Koller; Fiscal Year: 2013
    ..of structurally diverse lipophilic molecules including products of normal cellular metabolism, environmental pollutants, and xenobiotics including therapeutic agents...
  51. Human Cardio-Pulmonary System on a Chip
    Kevin Kit Parker; Fiscal Year: 2013
    ..b>Environmental pollutants, to include nanoscale allergens and toxins, have deleterious effects on both the healthy and diseased ..
  52. Nutrition and Superfund Chemical Toxicity
    Bernhard Hennig; Fiscal Year: 2013
    ..Nutritional intervention thus becomes a sensible way to address health problems associated with environmental pollutants. In the competing renewal, the investigators recognize this dual need for sensing/remediation and ..
  53. Heavy Metal and Drug Self-Administration: Mechanisms
    PAUL JEFFERSON WELLMAN; Fiscal Year: 2010
    ..e., lead contamination and cocaine use. Based on the available literature, there is reason to believe that environmental pollutants may increase vulnerability to drug addiction.
  54. Environmental Endocrine Disruption of Adipocyte Metabolism
    Robert M Sargis; Fiscal Year: 2013
    ..In particular Dr. Sargis will examine the effects of environmental pollutants on adipocyte metabolism and insulin signaling in order to understand the molecular mechanisms by which ..
  55. Mechanisms of Inflammation in Gestational Membranes
    Rita K Loch-Caruso; Fiscal Year: 2012
    ..research are: 1) initiation of inflammation in gestational membranes by noninfectious stimuli such as environmental pollutants, 2) activation of the MAPK pathway by infectious and noninfectious stimuli, and 3) cross-talk and ..
  56. Developmental programming of TCE induced autoimmune disease
    Kathleen M Gilbert; Fiscal Year: 2013
    ..There is evidence that idiopathic autoimmune disease can be triggered by exposure to certain environmental pollutants such as the solvent trichloroethylene (TCE)...
  57. Raman Studies of Mammalian Cytochromes P450
    JAMES ROBERT KINCAID; Fiscal Year: 2013
    ..The other subclass metabolizes exogenous substances including pharmaceuticals and environmental pollutants, preparing them for elimination...
  58. Pre- and Postnatal PBDE Exposure, Thyroid Hormones, and Neurodevelopment
    JULIE BETH HERBSTMAN; Fiscal Year: 2013
    ..This information will inform the urgent and ongoing policy debate about how best to regulate these and other ubiquitous environmental pollutants.
  59. A Wearable Wireless System for Real-Time Monitoring of Chemical Toxicants
    Nongjian Tao; Fiscal Year: 2010
    ..certain type of cancers, diabetes and autism, are linked to the exposure of individuals to various environmental pollutants. In order to fully establish the correlation between a disease and a specific pollutant, new tools to ..
  60. Multiscale Models for Synthetic Biology
    Yiannis Kaznessis; Fiscal Year: 2010
    ..biological constructs, from sensors of biochemical and chemical weapons, to devices that will remove environmental pollutants, to gene therapies...
  61. Rapid development of in vivo models for countermeasure discovery: organophosphate
    Randall T Peterson; Fiscal Year: 2010
    ..As novel chemical threats emerge (in the form of novel chemical warfare agents or environmental pollutants), the speed with which we are able to understand and counteract each threat will determine the magnitude ..
  62. International Society for Environmental Epidemiology 24th Annual Conference
    James Burch; Fiscal Year: 2012
    ..will facilitate the development of novel strategies to ameliorate public health burdens imposed by environmental pollutants, and enhance our understanding of environmental health across land, air, and sea...
  63. Impact of PAH carcinogen-DNA adducts on DNA methylation
    Nicholas Geacintov; Fiscal Year: 2003
    ..The polycyclic aromatic hydrocarbons (PAR) such as benzo[a]pyrene or dibenzo[a,1]pyrene are ubiquitous environmental pollutants. They are metabolized in vivo to highly genotoxic dihydrodiol epoxides (DE)...
  64. Impact of Environmental Pollutants on Breast Cancer and*
    Julia Brody; Fiscal Year: 2005
    ..abstract_text> ..
  65. CHLORINATED HYDROCARBONS EFFECTS ON MAMMALIAN SYSTEMS
    David Kupfer; Fiscal Year: 2003
    DESCRIPTION: (Adapted from the Investigator's Abstract) This study will examine the interaction of environmental pollutants, primarily pro-estrogenic/estrogenic pesticides and structurally related compounds (e.g...
  66. BIOCHEMICAL TOXICOLOGY OF CYTOCHROME P-450
    Andrew Parkinson; Fiscal Year: 1990
    ..the dual role of these isozymes in the metabolism of toxic xenobiotics (such as chemical carcinogens, environmental pollutants and drugs) and endogenous substrates (such as steroids, vitamins and fatty acids)...
  67. MECHANISMS OF OLFACTORY TRANSDUCTION
    John Teeter; Fiscal Year: 2003
    ..Aging, disease, drugs and environmental pollutants all adversely affect the perception of odors...
  68. REGULATION OF NA,K ATPASE BY THE AH RECEPTOR
    Mary Walker; Fiscal Year: 2004
    Human exposure during pregnancy to persistent environmental pollutants, like 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and related chemicals, results in decreased birth weights, neurological deficits, thyroid hormone alterations, lung ..
  69. Cytochrome P450-reductase interactions in P450 1A subfamily
    GRAZYNA SZKLARZ; Fiscal Year: 2007
    ..is present in lungs, is thought to be linked to lung cancer because this enzyme is able to metabolize environmental pollutants, such as polycyclic aromatic hydrocarbons (PAHs), to their carcinogenic derivatives...
  70. Glucuronidation in Humans--Genotypes and Phenotypes
    Johanna Lampe; Fiscal Year: 2004
    ..such as bilirubin and steroid hormones, and exogenous substrates, such as drugs, plant-food Constituents, environmental pollutants, and carcinogens...