toxic actions

Summary

Summary: A broad category of chemical actions with harmful or deadly effect on living organisms.

Top Publications

  1. ncbi Toxicity of citreoviridin
    K Nishie
    U S Department of Agriculture, R B Russell Agricultural Research Center, Athens, GA 30613
    Res Commun Chem Pathol Pharmacol 59:31-52. 1988
  2. ncbi Cellular responses to FMLP challenging: a mini-review
    M A Panaro
    Department of Human Anatomy, University of Bari, Italy
    Immunopharmacol Immunotoxicol 21:397-419. 1999
  3. ncbi Chlorhexidine prevents hypochlorous acid-induced inactivation of alpha1-antitrypsin
    Fabrizio Montecucco
    Division of Cardiology, Foundation for Medical Researches, Department of Medicine, Geneva University Hospital, Geneva, Switzerland
    Clin Exp Pharmacol Physiol 36:e72-7. 2009
  4. ncbi Myeloid clonogenic assays for comparison of the in vitro toxicity of alkylating agents
    D A Volpe
    Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, 5600 Fishers Lane, 20857, Rockville, MD, USA
    Toxicol In Vitro 17:271-7. 2003
  5. ncbi Comparative proteomics analysis reveals role of heat shock protein 60 in digoxin-induced toxicity in human endothelial cells
    Jie Qiu
    Department of Geriatrics, Qilu Hospital of Shandong University, 107 Wenhua Xi Road, Jinan 250012, PR China
    Biochim Biophys Acta 1784:1857-64. 2008
  6. ncbi 3-methylcholanthrene induces differential recruitment of aryl hydrocarbon receptor to human promoters
    Andrea Pansoy
    Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada
    Toxicol Sci 117:90-100. 2010
  7. ncbi Evidence for an intracellular site of action in the heart for two hydrophobic cardiac steroids
    Harol Núñez-Durán
    Laboratorio de Fisiologia Cardiovascular, Facultad de Medicina, Gral Flores 2125, Montevideo, 11600, Uruguay
    Life Sci 74:1337-44. 2004
  8. ncbi Dietary antioxidants and environmental stress
    Frank J Kelly
    Lung Biology, School of Health and Life Sciences, King s College, London, 150 Stamford Street, London SE19NN, UK
    Proc Nutr Soc 63:579-85. 2004
  9. ncbi [Case of ruptured multiple cerebral aneurysms associated with primary aldosteronism]
    Kana Sawada
    Department of Neurosurgery, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    No Shinkei Geka 38:347-51. 2010
  10. ncbi Expression of aryl hydrocarbon receptor and aryl hydrocarbon receptor nuclear translocator messenger ribonucleic acids and proteins in rat and human testis
    Rüdiger Schultz
    Department of Developmental Biology, Tampere University, FIN 33014 Tampere, Finland
    Endocrinology 144:767-76. 2003

Detail Information

Publications132 found, 100 shown here

  1. ncbi Toxicity of citreoviridin
    K Nishie
    U S Department of Agriculture, R B Russell Agricultural Research Center, Athens, GA 30613
    Res Commun Chem Pathol Pharmacol 59:31-52. 1988
    ..citreoviridin (CIT) isolated from Penicillium citreoviride was studied to elucidate the mechanism of its toxic actions. In CF#1 mice, near lethal doses of CIT decreased motor activities, body temperature and had cataleptic ..
  2. ncbi Cellular responses to FMLP challenging: a mini-review
    M A Panaro
    Department of Human Anatomy, University of Bari, Italy
    Immunopharmacol Immunotoxicol 21:397-419. 1999
    ..Finally, the receptor expression and the pharmacological and toxic actions of FMLP upon other tissues and organs, and its actions on the developing embryo, are illustrated.
  3. ncbi Chlorhexidine prevents hypochlorous acid-induced inactivation of alpha1-antitrypsin
    Fabrizio Montecucco
    Division of Cardiology, Foundation for Medical Researches, Department of Medicine, Geneva University Hospital, Geneva, Switzerland
    Clin Exp Pharmacol Physiol 36:e72-7. 2009
    ..several enzymes, including elastase and myeloperoxidase (MPO), which contribute to tissue injury via direct toxic actions, the generation of oxidants and inactivation of protective factors, such as alpha1-antitrypsin (alpha1-AT)...
  4. ncbi Myeloid clonogenic assays for comparison of the in vitro toxicity of alkylating agents
    D A Volpe
    Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, 5600 Fishers Lane, 20857, Rockville, MD, USA
    Toxicol In Vitro 17:271-7. 2003
    ..HPP-CFC proved to be the least sensitive of the progenitors to the toxic actions of the drugs...
  5. ncbi Comparative proteomics analysis reveals role of heat shock protein 60 in digoxin-induced toxicity in human endothelial cells
    Jie Qiu
    Department of Geriatrics, Qilu Hospital of Shandong University, 107 Wenhua Xi Road, Jinan 250012, PR China
    Biochim Biophys Acta 1784:1857-64. 2008
    Although digitalis has been used in clinical treatment extensively, the precise mechanism of its toxic actions on cardiovascular system remained unclear, it would be of interest to study the differential proteomic analysis of vascular ..
  6. ncbi 3-methylcholanthrene induces differential recruitment of aryl hydrocarbon receptor to human promoters
    Andrea Pansoy
    Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada
    Toxicol Sci 117:90-100. 2010
    The aryl hydrocarbon receptor (AHR) is a ligand-activated protein that mediates the toxic actions of polycyclic aromatic and halogenated compounds...
  7. ncbi Evidence for an intracellular site of action in the heart for two hydrophobic cardiac steroids
    Harol Núñez-Durán
    Laboratorio de Fisiologia Cardiovascular, Facultad de Medicina, Gral Flores 2125, Montevideo, 11600, Uruguay
    Life Sci 74:1337-44. 2004
    ..While many results indicate that inhibition of Na+,K+-ATPase underlies both the therapeutic and toxic actions of CS, other studies suggest that actions on the SR membrane system may be important...
  8. ncbi Dietary antioxidants and environmental stress
    Frank J Kelly
    Lung Biology, School of Health and Life Sciences, King s College, London, 150 Stamford Street, London SE19NN, UK
    Proc Nutr Soc 63:579-85. 2004
    ..Recently, oxidative stress has been identified as a unifying feature underlying the toxic actions of these pollutants...
  9. ncbi [Case of ruptured multiple cerebral aneurysms associated with primary aldosteronism]
    Kana Sawada
    Department of Neurosurgery, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    No Shinkei Geka 38:347-51. 2010
    ..Recent studies have demonstrated that hyperaldosteronism might have direct vasculo-toxic actions, including remodeling, fibrosis, and proliferation...
  10. ncbi Expression of aryl hydrocarbon receptor and aryl hydrocarbon receptor nuclear translocator messenger ribonucleic acids and proteins in rat and human testis
    Rüdiger Schultz
    Department of Developmental Biology, Tampere University, FIN 33014 Tampere, Finland
    Endocrinology 144:767-76. 2003
    ..receptor (AHR)/aryl hydrocarbon receptor nuclear translocator (ARNT) receptor complex to mediate their toxic actions. In addition to interaction with environmental pollutants, several transcription factors, steroid receptors, ..
  11. pmc Therapeutic photobiomodulation for methanol-induced retinal toxicity
    J T Eells
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Proc Natl Acad Sci U S A 100:3439-44. 2003
    ..to monochromatic red radiation from light-emitting diode (LED) arrays would protect the retina against the toxic actions of methanol-derived formic acid in a rodent model of methanol toxicity...
  12. ncbi Dual acting anti-inflammatory drugs
    S Leone
    Division of Clinical Pharmacology, School of Medicine, University of Modena and Reggio Emilia, Modena, Italy
    Curr Top Med Chem 7:265-75. 2007
    ..In addition, the dual inhibition of both COX and 5-LOX is neuroprotective by suppressing toxic actions of reactive microglia and macrophages, that are increased in aging brain and in age-related degenerative ..
  13. ncbi Mutation, DNA strand cleavage and nitric oxide formation caused by N-nitrosoproline with sunlight: a possible mechanism of UVA carcinogenicity
    Sakae Arimoto-Kobayashi
    Faculty of Pharmaceutical Sciences, Okayama University, Tsushima, Okayama 700 8530, Japan
    Carcinogenesis 23:1537-40. 2002
    ..The co-mutagenic and co-toxic actions of NPRO and sunlight merit attention as possible mechanisms increasing the carcinogenic risk from UVA ..
  14. ncbi Methionine sulfoximine shows excitotoxic actions in rat cortical slices
    C A Shaw
    Department of Ophthalmology, The University of British Columbia, Vancouver, Canada
    Can J Physiol Pharmacol 77:871-7. 1999
    ..In the present investigation, we report excitatory and toxic actions of MSO in an in vitro preparation of adult rat cortex...
  15. pmc Expression and functional activity of PPARgamma in pancreatic beta cells
    Hannah J Welters
    Institute of Biomedical and Clinical Science, Peninsula Medical School, Plymouth, Devon, UK
    Br J Pharmacol 142:1162-70. 2004
    ..Rosiglitazone failed to protect BRIN-BD11 cells from the toxic actions of palmitate at concentrations up to 50 microm...
  16. ncbi Protein kinase C does not mediate the inhibitory action of lead on vitamin D3-dependent production of osteocalcin in osteoblastic bone cells
    Partow Guity
    Institute of Chemical Toxicology, Wayne State University, Detroit, Michigan 48201, USA
    Toxicol Appl Pharmacol 178:109-16. 2002
    ..8). It is often suggested that activation of protein kinase C (PKC) is a critical mediator of the toxic actions of lead...
  17. ncbi SNAP, a NO donor, induces cellular protection only when cortical neurons are submitted to some aggression process
    S Figueroa
    Instituto de Bioquímica Centro Mixto CSIC UCM, Facultad de Farmacia, Plaza Ramon y Cajal s n Ciudad Universitaria, 28040 Madrid, Spain
    Brain Res 1034:25-33. 2005
    ..Its protective and toxic actions have been already evidenced in several cell types...
  18. ncbi Disordered proteins: biological membranes as two-dimensional aggregation matrices
    Roberth Byström
    Department of Chemistry, Umea University, 90187, Umea, Sweden
    Cell Biochem Biophys 52:175-89. 2008
    ..of the involvement of membranes in folding/misfolding processes in vivo, which might be quite universal and important for future research concerning amyloidogenic and misfolding proteins, and possible ways to prevent their toxic actions.
  19. ncbi Impaired female sexual behavior of rat offspring exposed to Solanum lycocarpum unripe fruits during gestation and lactation: lack of hormonal and fertility alterations
    Aline Schwarz
    Programa de Pós Graduação, Departamento de Toxicologia e Análises Toxicológicas, Faculdade de Ciencias Farmaceuticas, Universidade de Sao Paulo, Sao Paulo SP, Brazil
    Pharmacol Biochem Behav 81:928-34. 2005
    ..These changes observed can be the direct consequence of the toxic actions of the steroidal alkaloid on the female offspring during fetal development.
  20. pmc Gene-expression changes in cerium chloride-induced injury of mouse hippocampus
    Zhe Cheng
    Medical College of Soochow University, Suzhou, PR China
    PLoS ONE 8:e60092. 2013
    ..to enter the ecological environment, is then transferred to humans through food chains, and causes toxic actions in several organs including the brain of animals...
  21. ncbi Effect of cardiac glycosides on action potential characteristics and contractility in cat ventricular myocytes: role of calcium overload
    Stuart R Ruch
    Department of Medicine, Feinberg Cardiovascular Research Institute, Northwestern University Medical School, Chicago, IL 60611, USA
    J Pharmacol Exp Ther 307:419-28. 2003
    ..of AP duration shortening and positive inotropy elicited by each agent is limited by development of their toxic actions. The quantitative differences between cardiac glycosides suggest that mechanisms independent of sodium pump ..
  22. ncbi Metal ions affecting the neurological system
    Hana R Pohl
    Agency for Toxic Substances and Disease Registry, U S Department of Health and Human Services, Atlanta GA 30333, USA
    Met Ions Life Sci 8:247-62. 2011
    ..It is, therefore, expected that interactions or "joint toxic actions" may occur in populations exposed to mixtures of metals or to mixtures of metals with other chemicals...
  23. ncbi Correlating the clinical actions and molecular mechanisms of general anesthetics
    Ken Solt
    Department of Anesthesia and Critical Care, Massachusetts General Hospital, Boston, MA 02114, USA
    Curr Opin Anaesthesiol 20:300-6. 2007
    ..To summarize recent in-vitro and in-vivo research on molecular mechanisms of general anesthetics' actions...
  24. ncbi [Toxicological characteristic of neuroleptics--substituted benzamides]
    R A Kalekin
    Sud Med Ekspert 50:31-4. 2007
    ..Substituted benzamides intake causes toxic actions: psychotropic and neurotoxic...
  25. ncbi Insulin resistance induced by high-fructose diet potentiates carbon tetrachloride hepatotoxicity
    M Pooranaperundevi
    Department of Biochemistry and Biotechnology, Annamalai University, Tamil Nadu, India
    Toxicol Ind Health 26:89-104. 2010
    ..The present study investigates the susceptibility of liver to the toxic actions of carbon tetrachloride (CCl(4)) in a rat model of IR, induced by feeding a high-fructose diet (60 g/100 g) ..
  26. ncbi Prediction of biological activity spectra via the Internet
    A Sadym
    Institute of Biomedical Chemistry of Russian Academy of Medical Sciences, Pogodinskaya Street 10, Moscow, 119121, Russia
    SAR QSAR Environ Res 14:339-47. 2003
    The majority of biologically active compounds have both pharmacotherapeutic and side/toxic actions. To estimate general efficacy and safety of the molecules under study, their biological potential should be thoroughly evaluated...
  27. ncbi Chronic exposure to sulfide causes accelerated degradation of cytochrome c oxidase in ethylmalonic encephalopathy
    Ivano Di Meo
    Unit of Molecular Neurogenetics, Pierfranco and Luisa Mariani Center for Research on Children s Mitochondrial Disorders, Institute of Neurology Carlo Besta IRCCS Foundation, Milan, Italy
    Antioxid Redox Signal 15:353-62. 2011
    ..cannot be fully explained by the sole defect of COX in critical tissues, but are likely consequent to several toxic actions on a number of enzymatic activities in different tissues, including endothelial lining of the small vessels, ..
  28. ncbi Feasibility of a simple double-layered coculture system incorporating metabolic processes of the intestine and liver tissue: application to the analysis of benzo[a]pyrene toxicity
    Sue Choi
    Institute of Industrial Science, University of Tokyo, 4 6 1 Komaba, Meguro ku, Tokyo, 153 8505, Japan
    Toxicol In Vitro 18:393-402. 2004
    ..As such, the simple double-layered coculture system can provide more accurate information regarding the toxic actions of the hazardous chemicals in humans than a pure culture system, as it also gives the final toxicity as a ..
  29. ncbi Development of learned flavor preferences
    Kevin P Myers
    Department of Psychology, Bucknell University, Lewisburg, PA, USA
    Dev Psychobiol 48:380-8. 2006
    ..Thus, from an early age, learning processes shape the feeding behavior of animals. While primarily serving an adaptive function, learning may play a role in biasing individuals towards excessive intake and weight gain...
  30. pmc Effects of selected food phytochemicals in reducing the toxic actions of TCDD and p,p'-DDT in U937 macrophages
    Eric M Sciullo
    Department of Environmental Toxicology, University of California Davis, 3792 Old Davis Rd, Davis, CA 95616, USA
    Arch Toxicol 84:957-66. 2010
    ..In conclusion, zerumbone and auraptene were identified to be the most effective agents in protecting U937 macrophages from developing these cell toxic effects of TCDD and DDT...
  31. ncbi The syndrome of irreversible lithium-effectuated neurotoxicity
    - Adityanjee
    Schizophrenia and Psychotic Disorders Program, Psychiatry Service, Minneapolis VA Medical Center, Minneapolis, Minnesota 55417, USA
    Clin Neuropharmacol 28:38-49. 2005
    ..The authors review the published cases of SILENT reported in the literature and discuss various clinical manifestations...
  32. ncbi alpha-Tocopherol modifies lead induced functional changes at murine neuromuscular junction
    M Y Hasan
    Department of Pharmacology, Faculty of Medicine, UAE University, Al Ain, United Arab Emirates
    Free Radic Res 38:1321-8. 2004
    Lead impacts neuromuscular junction and might induce skeletal muscle weakness. Antioxidants may prevent toxic actions of lead on muscle...
  33. ncbi Gamma-linolenic acid therapy of human glioma-a review of in vitro, in vivo, and clinical studies
    Undurti N Das
    UND Life Sciences, Shaker Heights, OH 42100, USA
    Med Sci Monit 13:RA119-31. 2007
    ..of oncogenes ras, and Bcl-2, enhanced the activity of p53, protected normal cells and tissues from the toxic actions of radiation and anti-cancer drugs, enhanced the cytotoxic action of anti-cancer drugs and reversed tumor cell ..
  34. ncbi Inhibitory effects of Piper umbellatum and Piper peltatum extracts towards myotoxic phospholipases A2 from Bothrops snake venoms: isolation of 4-nerolidylcatechol as active principle
    Vitelbina Núñez
    Instituto Clodomiro Picado, Facultad de Microbiologia, Universidad de Costa Rica, San Jose, Costa Rica
    Phytochemistry 66:1017-25. 2005
    Phospholipases A(2) (PLA(2)) are important constituents of snake venoms, being responsible for several of their toxic actions. Extracts from plants used in folk medicine were screened for inhibition of the enzymatic activity of myotoxin ..
  35. ncbi Are there negative CNS impacts of aluminum adjuvants used in vaccines and immunotherapy?
    Christopher A Shaw
    Neural Dynamics Research Group, 828 W 10th Ave, Vancouver, BC, V5Z 1L8, Canada
    Immunotherapy 6:1055-71. 2014
    ..the literature on Al neurotoxicity and the use of Al salts as vaccine adjuvants and consider not only direct toxic actions on the nervous system, but also the potential impact for triggering autoimmunity...
  36. ncbi Peroxynitrite causes aspartate release from dissociated rat cerebellar granule neurones
    M A Moro
    Departamento de Farmacologia, Facultad de Medicina, Universidad Complutense de Madrid, Spain
    Free Radic Res 28:193-204. 1998
    ..It has therefore been proposed to mediate the toxic actions caused by NO...
  37. ncbi Role of neurotrophins and lectins in prevention of ototoxicity
    W Q Gao
    Department of Neuroscience, Genentech, Inc, South San Francisco, California 94080, USA
    Ann N Y Acad Sci 884:312-27. 1999
    ..Postnatal rat cochlear explant cultures are used to study the toxic actions of different classes of ototoxins and to identify molecules that can protect SGN and HC from ototoxic damage...
  38. ncbi Mdr P-glycoproteins are not essential for biliary excretion of the hydrophobic heme precursor protoporphyrin in a griseofulvin-induced mouse model of erythropoietic protoporphyria
    Torsten Plosch
    Center for Liver, Digestive, and Metabolic Diseases, Groningen University Institute for Drug Exploration, Departments of Pediatrics and Gastroenterology, University Hospital Groningen, Groningen, The Netherlands
    Hepatology 35:299-306. 2002
    Hepatic complications in erythropoietic protoporphyria (EPP) have been attributed to toxic actions of accumulated protoporphyrin (PP). PP can only be removed via the bile but transport systems involved have not been defined...
  39. pmc Inhibition of toxic actions of phospholipase A2 isolated & characterized from the Indian Banded Krait (Bungarus fasciatus) venom by synthetic herbal compounds
    Antony Gomes
    Department of Physiology, University of Calcutta, Kolkata, India
    Indian J Med Res 136:40-5. 2012
    ....
  40. ncbi Amino acid sequence and biological characterization of BlatPLA₂, a non-toxic acidic phospholipase A₂ from the venom of the arboreal snake Bothriechis lateralis from Costa Rica
    Marco Van der Laat
    Instituto Clodomiro Picado, Facultad de Microbiologia, Universidad de Costa Rica, San José 11501, Costa Rica
    Toxicon 73:71-80. 2013
    ..at increasing our knowledge on the structural and functional characteristics of group II acidic PLA₂s, whose toxic actions are generally more restricted than those displayed by basic PLA₂s...
  41. ncbi Anticocaine catalytic antibodies
    Shi Xian Deng
    Division of Clinical Pharmacology and Experimental Therapeutics, Department of Medicine, Columbia University, Box 84, 630 W 168th Street, New York, NY 10032, USA
    J Immunol Methods 269:299-310. 2002
    Cocaine mediates its reinforcing and toxic actions through a "loss of function" effect at multiple receptors...
  42. ncbi Chronic cholestatic liver diseases: clues from histopathology for pathogenesis
    Marion J Pollheimer
    Division of Gastroenterology and Hepatology, Laboratory of Experimental and Molecular Hepatology, Department of Internal Medicine, Medical University of Graz, Austria Institute of Pathology, Medical University of Graz, Austria
    Mol Aspects Med 37:35-56. 2014
    ..As the cholangiocyte's apical membrane is exposed to the toxic actions of the bile fluid, the interaction of bile with cholangiocytes and the biliary tree in general must be ..
  43. ncbi Interaction of metal ions with neurotransmitter receptors and potential role in neurodiseases
    Carla Marchetti
    Istituto di Biofisica, Consiglio Nazionale delle Ricerche, Via De Marini, 6, 16149, Genoa, Italy
    Biometals 27:1097-113. 2014
    ..trace metals, zinc (Zn) and copper (Cu), which are essential for several enzymatic functions, but can mediate toxic actions if deregulated...
  44. ncbi Cocaine produces D2R-mediated conformational changes in the adenosine A(2A)R-dopamine D2R heteromer
    Daniel Marcellino
    Department of Neuroscience, Karolinska Institutet, Retzius vag 8, Stockholm 17177, Sweden
    Biochem Biophys Res Commun 394:988-92. 2010
    ..effects of a concentration of cocaine known to fully block the dopamine (DA) transporter without exerting any toxic actions were investigated on A(2A)R and D(2L)R formed heteromers in transiently co-transfected HEK-293T cells...
  45. ncbi Discovering and targeting the basic mechanism of neurodegeneration: the role of peptides from the C-terminus of acetylcholinesterase: non-hydrolytic effects of ache: the actions of peptides derived from the C-terminal and their relevance to neurodegenerat
    Susan Greenfield
    University Dept of Pharmacology, Oxford OX1 3QT, United Kingdom
    Chem Biol Interact 203:543-6. 2013
    ..We have subsequently been able to ascribe the trophic-toxic actions of the both T14 and T30 peptides to the modulation of calcium influx via an allosteric site on the alpha-7 ..
  46. ncbi Induction of cytokine release by the acyl glucuronide of mycophenolic acid: a link to side effects?
    E Wieland
    Abteilung Klinische Chemie, Georg August Universitat Gottingen, Gottingen, Germany
    Clin Biochem 33:107-13. 2000
    ..This study investigated whether M-2 can induce IL-6 and TNF-alpha release as well as gene expression of these cytokines in leukocytes...
  47. ncbi Caveolin-1 interacts with alpha-synuclein and mediates toxic actions of cellular alpha-synuclein overexpression
    Alexandra Madeira
    Center for Molecular Medicine, Section of Translational Neuropharmacology, Department of Clinical Neuroscience, Karolinska Institute, SE 17177 Stockholm, Sweden
    Neurochem Int 59:280-9. 2011
    ....
  48. ncbi Mechanism of drug and toxic actions of gossypol: focus on reactive oxygen species and electron transfer
    Peter Kovacic
    Department of Chemistry, San Diego State University, San Diego, CA 92182 0130, USA
    Curr Med Chem 10:2711-8. 2003
    ..Mechanistic aspects are addressed with OS-ROS-ET as the guiding theme, in addition to other modes of action resulting in a multifaceted scenario...
  49. ncbi The changing view of acrylamide neurotoxicity
    Richard M LoPachin
    Department of Anesthesiology, Albert Einstein College of Medicine, Anesthesia Research, Moses 7, Montefiore Medical Center, 111 E 210th St, Bronx, NY 10467, USA
    Neurotoxicology 25:617-30. 2004
    ..4998] regarding the presence of ACR in potato and grain-based foods, there has been a renewed interest in the toxic actions of this chemical. Therefore, in this review, we consider the different toxic effects of ACR...
  50. ncbi GABAergic deafferentation hypothesis of brain aging and Alzheimer's disease revisited
    T J Marczynski
    Department of Pharmacology, College of Medicine, University of Illinois, Chicago 60612, USA
    Brain Res Bull 45:341-79. 1998
    ..Mg2+ control of the N-methyl-D-aspartate (NMDA) channels, thereby enabling Ca2+-dependent persistent toxic actions of the excitatory amino acids (EAA); and 5) in whole-cell patch-clamp recording from neurons of aging rats, ..
  51. ncbi Synergistic vascular toxicity and fatty acid anilides in the toxic oil syndrome
    P J Boor
    Department of Pathology, University of Texas Medical Branch, Galveston 77550
    J Am Coll Cardiol 18:1824-8. 1991
    ..The theoretic metabolism of fatty acid anilides is discussed. Recent data concerning the toxic actions of the anilides of oleic and linoleic acid are given...
  52. ncbi Effects of theophylline on inotropic and arrhythmogenic actions of cardiotonic steroids in guinea pig cardiac muscle
    R Kafiluddi
    Department of Pharmacology and Interdisciplinary Toxicology, University of Arkansas for Medical Sciences, Little Rock
    J Pharmacol Exp Ther 244:556-63. 1988
    ..This study was designed to examine effects of theophylline, a methylxanthine, on both the positive inotropic and toxic actions of cardiotonic steroids in cardiac muscle isolated from guinea pig heart...
  53. ncbi In vitro and in vivo studies on some toxic effects of the venom from Hemiscorpious lepturus scorpion
    Mohammad Hassan Pipelzadeh
    Department of Pharmacology, Ahwaz Jundishapur University of Medical Sciences, Iran
    Toxicon 48:93-103. 2006
    ..histological, biochemical methods as well as complete blood cell count were used to assess these toxic actions. In addition, in vitro haemolysis studies on human washed blood suspension and cytotoxicity on cultured ..
  54. ncbi Identification of the major arsenic-binding protein in rat plasma as the ternary dimethylarsinous-hemoglobin-haptoglobin complex
    Hua Naranmandura
    Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 260 8675, Japan
    Chem Res Toxicol 21:678-85. 2008
    ..However, little is known about the mechanisms underlying these toxic actions. The metabolism of arsenic is essential for understanding the toxic actions...
  55. ncbi Ameliorative action of cyanobacterial phycoerythrin on CCl(4)-induced toxicity in rats
    Badrish Soni
    BRD School of Biosciences, Sardar Patel Maidan, Vadtal Road, Satellite Campus, Post Box 39, Sardar Patel University, Vallabh Vidyanagar 388120, Gujarat, India
    Toxicology 248:59-65. 2008
    ..Carbon tetrachloride is also well known for hepatic and renal toxic actions. The in vivo metabolism of carbon tetrachloride to trichloromethyl (CCl(3)) and peroxy trichloromethyl (OOCCl(..
  56. ncbi DDT house spraying and re-emerging malaria
    D R Roberts
    Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Lancet 356:330-2. 2000
    ..Early studies of DDT showed repellent, irritant, and toxic actions that worked against malaria vector mosquitoes...
  57. ncbi DNA microarrays detect 4-nonylphenol-induced alterations in gene expression during zebrafish early development
    P R Hoyt
    Oak Ridge National Laboratory, PO Box 2008, Oak Ridge, TN 37831, USA
    Ecotoxicology 12:469-74. 2003
    ..advances in the biological sciences have led to a growing realization of the inherent complexity of the toxic actions of man-made chemicals and industrial compounds...
  58. ncbi Phosphoprotein levels, MAPK activities and NFkappaB expression are affected by fisetin
    Roberta R Ruela de Sousa
    Department of Biochemistry, State University of Campinas, Campinas, SP, Brazil
    J Enzyme Inhib Med Chem 22:439-44. 2007
    ..Our findings reinforce the hypothesis that fisetin is likely to exert beneficial and/or toxic actions on cells not through its potential as antioxidant but rather through its modulation of protein kinase and ..
  59. ncbi [Sir Arthur Conan Doyle, Sherlock Holmes and infectious diseases]
    Walter Ledermann D
    Hospital Luis Calvo Mackenna, Santiago Chile
    Rev Chilena Infectol 27:429-34. 2010
    ..Also he makes his hero discovers the toxic actions of a medusa and a transplant of solid organ...
  60. pmc Impact of sustained exposure to β-amyloid on calcium homeostasis and neuronal integrity in model nerve cell system expressing α4β2 nicotinic acetylcholine receptors
    Komal Arora
    Department of Cell and Molecular Biology, John A Burns School of Medicine, University of Hawaii at Manoa, Honolulu, Hawaii 96813, USA
    J Biol Chem 288:11175-90. 2013
    ..Together, the results suggest that the presence of nAChRs sensitizes neurons to the toxic actions of soluble oligomeric Aβ, perhaps contributing to the cholinergic deficit in Alzheimer disease.
  61. ncbi Dopaminergic neurotoxins require excitotoxic stimulation in organotypic cultures
    Geraldine J Kress
    Department of Pharmacology, University of Pittsburgh, W1351 Biomedical Science Tower, Pittsburgh, PA 15261, USA
    Neurobiol Dis 20:639-45. 2005
    ..Thus, in a model culture system where dopaminergic neurons innervate appropriate targets, excitotoxicity appears to be essential for the manifestation of the toxic actions of 6-hydroxydopamine, 1-methyl-4-phenylpyridinium and rotenone.
  62. ncbi Different effects of vinblastine on the polymerization of isotypically purified tubulins from bovine brain
    Israr A Khan
    Department of Biochemistry, University of Texas Science Center, San Antonio, TX 78229 3900, USA
    Invest New Drugs 21:3-13. 2003
    ..These results may be relevant to the therapeutic and toxic actions of vinblastine.
  63. ncbi Environmental toxicity of PFCs: an enhanced integrated biomarker assessment and structure-activity analysis
    Changhui Liu
    School of Civil and Environmental Engineering, Nanyang Technological University, Singapore
    Environ Toxicol Chem 32:2226-33. 2013
    ..recognized chain length and functional group effects, several structural factors are also involved in the toxic actions of PFCs, including hydrophobicity and molecular size, and so on...
  64. ncbi Investigation of the antiviral properties of copper iodide nanoparticles against feline calicivirus
    Nozomi Shionoiri
    Division of Biotechnology and Life Science, Institute of Engineering, Tokyo University of Agriculture and Technology, 2 24 16 Naka cho, Koganei, Tokyo 184 8588, Japan
    J Biosci Bioeng 113:580-6. 2012
    ..CuI nanoparticles could be proposed as useful sources of a continuous supply of Cu(+) ions for efficient virus inactivation. Furthermore, this study brings new insights into toxic actions of copper iodide nanoparticles against viruses.
  65. ncbi PM10-induced hospital admissions for asthma and chronic obstructive pulmonary disease: the modifying effect of individual characteristics
    Cristina Canova
    MRC HPA Centre for Environment and Health, Imperial College, London, United Kingdom
    Epidemiology 23:607-15. 2012
    Evidence suggests that oxidative stress is a unifying feature underlying the toxic actions of particulate matter (PM)...
  66. pmc Effect of glutamate and riluzole on manganese-induced apoptotic cell signaling in neuronally differentiated mouse P19 Cells
    Jerome A Roth
    Department of Pharmacology and Toxicology, University at Buffalo, Buffalo, NY 14214, USA
    Neurochem Int 61:25-33. 2012
    ..receive glutamatergic input from the subthalamic nuclei which has been suggested to be involved in the toxic actions of Mn...
  67. ncbi Synaptic aging is associated with mitochondrial dysfunction, reduced antioxidant contents and increased vulnerability to amyloid-β toxicity
    Ricardo Quiroz-Baez
    Departamento de Medicina Genómica y Toxicología Ambiental, Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico, Mexico DF, Mexico
    Curr Alzheimer Res 10:324-31. 2013
    ..Synaptic failure appears to depend on the toxic actions of small and soluble amyloid-β (Aβ) oligomers...
  68. ncbi Toxic actions of dinoseb in medaka (Oryzias latipes) embryos as determined by in vivo 31P NMR, HPLC-UV and 1H NMR metabolomics
    Mark R Viant
    School of Biosciences, The University of Birmingham, Edgbaston, UK
    Aquat Toxicol 76:329-42. 2006
    ....
  69. pmc Rapid and robust protection against cocaine-induced lethality in rats by the bacterial cocaine esterase
    Ziva D Cooper
    Department of Pharmacology, University of Michigan, 1301 MSRB III, 1150 West Med Cntr Dr, Ann Arbor, MI 48109 0632, USA
    Mol Pharmacol 70:1885-91. 2006
    There is no approved means to prevent the toxic actions of cocaine...
  70. ncbi Resistance of HepG2 cells against the adverse effects of ethanol related to neutral lipid and phospholipid metabolism
    Jose M Jimenez-Lopez
    Faculty of Sciences, Department of Biochemistry and Molecular Biology, University of Granada, Avenida Fuentenueva s n, Granada 18001, Spain
    Biochem Pharmacol 63:1485-90. 2002
    ..involved in the ethanol metabolism (namely cytochrome P(450)2E1) and also are devoid of alcohol dehydrogenase activity, we propose that the toxic actions of ethanol on liver must be linked to the activity of one or both of these systems.
  71. ncbi Glyphosate formulations induce apoptosis and necrosis in human umbilical, embryonic, and placental cells
    Nora Benachour
    University of Caen, Laboratory Estrogens and Reproduction, UPRES EA 2608, Institute of Biology, Caen 14032, France
    Chem Res Toxicol 22:97-105. 2009
    ..This should be discussed when analyzing the in vivo toxic actions of R. This work clearly confirms that the adjuvants in Roundup formulations are not inert...
  72. pmc Oxidation of CaMKII determines the cardiotoxic effects of aldosterone
    B Julie He
    Department of Molecular Physiology and Biophysics, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA
    Nat Med 17:1610-8. 2011
    ..Here we show that aldosterone exerts direct toxic actions on myocardium by oxidative activation of CaMKII, causing cardiac rupture and increased mortality in mice after ..
  73. ncbi Isolation of an acidic phospholipase A2 from the venom of the snake Bothrops asper of Costa Rica: biochemical and toxicological characterization
    JULIAN FERNANDEZ
    Instituto Clodomiro Picado, Facultad de Microbiologia, Universidad de Costa Rica, San Jose, Costa Rica
    Biochimie 92:273-83. 2010
    Phospholipases A(2) (PLA(2)) are major components of snake venoms, exerting a variety of relevant toxic actions such as neurotoxicity and myotoxicity, among others...
  74. ncbi Membrane cholesterol modulates the cytolytic mechanism of myotoxin II, a Lys49 phospholipase A2 homologue from the venom of Bothrops asper
    José Rangel
    Instituto Clodomiro Picado, Facultad de Microbiologia, Universidad de Costa Rica, San Jose, Costa Rica
    Cell Biochem Funct 29:365-70. 2011
    ..The toxic actions of myotoxin I, a catalytically active PLA2 from the same venom, as well as of the cytolytic peptide melittin ..
  75. ncbi The natural xanthone alpha-mangostin reduces oxidative damage in rat brain tissue
    Berenice Márquez-Valadez
    Laboratorio de Aminoácidos Excitadores, Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez, Insurgentes Sur México DF, Mexico
    Nutr Neurosci 12:35-42. 2009
    ..Two reliable biological preparations (rat brain homogenates and synaptosomal P2 fractions) were exposed to the toxic actions of a free radical generator (ferrous sulfate), an excitotoxic agent (quinolinate), and a mitochondrial toxin (..
  76. ncbi CYP1A1 and CYP3A4 modulation by dietary flavonoids in human intestinal Caco-2 cells
    Thérèse Sergent
    Biochimie Cellulaire, Nutritionnelle and Toxicologique, Institut des Sciences de la Vie, Academie Universitaire Louvain, UCL Louvain la Neuve, Croix du Sud 5, B 1348 Louvain la Neuve, Belgium
    Toxicol Lett 191:216-22. 2009
    ..However, evidence of potential toxic actions has also emerged...
  77. ncbi Experimental testing of skin reactions to insulin detemir in diabetes patients naïve to insulin detemir
    Kenichiro O'goshi
    Department of Dermatology, Bispebjerg Hospital, Copenhagen, Denmark
    Skin Res Technol 17:411-9. 2011
    ..The purpose of this experimental study using a provocative design was to elucidate the potential mechanisms behind such skin reactions...
  78. ncbi Characterization of spatial repellent, contact irritant, and toxicant chemical actions of standard vector control compounds
    Nicole L Achee
    Uniformed Services University of the Health Sciences, Department of Preventive Medicine and Biometrics, 4301 Jones Bridge Road, Bethesda, MD 20814 4799, USA
    J Am Mosq Control Assoc 25:156-67. 2009
    ..Results show chemicals exert different combinations of contact irritant, spatial repellent, and toxic actions. This is true even within the same chemical class...
  79. ncbi Sensitivity of acute myeloid leukemia Kasumi-1 cells to binase toxic action depends on the expression of KIT and АML1-ETO oncogenes
    Vladimir A Mitkevich
    Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia
    Cell Cycle 10:4090-7. 2011
    ..Kasumi-1 cells were the most responsive to the toxic actions of binase among the cell lines used in this work with an IC50 value of 0.56 µM...
  80. ncbi Metabolic responses produced by crude versus dispersed oil in Chinook salmon pre-smolts via NMR-based metabolomics
    April R Van Scoy
    Department of Environmental Toxicology, College of Agricultural and Environmental Sciences, University of California, Davis, CA 95616 8588, USA
    Ecotoxicol Environ Saf 73:710-7. 2010
    ..This investigation compared the toxic actions of the water-accommodated fraction (WAF) and the chemically-enhanced WAF (CEWAF; Corexit 9500) of Prudhoe Bay ..
  81. ncbi A high throughput screening system for determining the three actions of insecticides against Aedes aegypti (Diptera: Culicidae) populations in Thailand
    Kanutcharee Thanispong
    Department of Entomology, Faculty of Agriculture, Kasetsart University, Bangkok 10900, Thailand
    J Med Entomol 47:833-41. 2010
    ..In this study, the deterrent and toxic actions of three synthetic pyrethroids and DDT were characterized on six field strains of Aedes aegypti from Thailand ..
  82. ncbi Neuronal membranes are key to the pathogenesis of Alzheimer's disease: the role of both raft and non-raft membrane domains
    R Williamson
    Biomedical Research Institute, University of Dundee, Ninewells Hospital, Dundee DD1 9SY, Scotland, UK
    Curr Alzheimer Res 8:213-21. 2011
    ..membrane domain composition has a direct impact on both the generation of β-amyloid and its subsequent toxic actions and as such is a key target for the development of therapeutic strategies...
  83. ncbi Roles of dioxins and heavy metals in cancer and neurological diseases using ROS-mediated mechanisms
    José M Matés
    Departmento de Biología Molecular y Bioquímica, Facultad de Ciencias, Campus de Teatinos, Universidad de Malaga, 29071 Malaga, Spain
    Free Radic Biol Med 49:1328-41. 2010
    ..Dioxins exert their toxic actions by acting on phase I and phase II enzymes, such as cytochromes P450, superoxide dismutase, and glutathione ..
  84. ncbi Metabotropic glutamate receptor 1 mediates the electrophysiological and toxic actions of the cycad derivative beta-N-Methylamino-L-alanine on substantia nigra pars compacta DAergic neurons
    Maria Letizia Cucchiaroni
    Santa Lucia Foundation Istituto di Ricovero e Cura a Carattere Scientifico, 00143 Rome, Italy
    J Neurosci 30:5176-88. 2010
    ..Moreover, environmental exposure to BMAA might possibly also contribute to idiopathic PD...
  85. pmc Comparison of the protective actions of N-acetylcysteine, hypotaurine and taurine against acetaminophen-induced hepatotoxicity in the rat
    Miteshkumar Acharya
    Department of Pharmaceutical Sciences, St, John s University, College of Pharmacy and Allied Health Professions, 8000 Utopia Parkway, Jamaica, New York 11439, USA
    J Biomed Sci 17:S35. 2010
    ..demonstrate equivalent patterns of protection and, to a certain extent, equipotent protective actions against the toxic actions of APAP in the liver when tested in equimolar doses and under the same conditions in an animal model.
  86. ncbi Nicotine withdrawal alleviates acetic acid-induced gastric injury in rats
    Mustafa Deniz
    Marmara University, School of Medicine, Department of Physiology, Haydarpasa 34668, Istanbul, Turkey
    Environ Toxicol Pharmacol 27:200-5. 2009
    ..In order to associate the toxic actions of nicotine on gastric mucosa with alterations of anxiety level and to evaluate the impact of nicotine ..
  87. ncbi Cellular alterations of mucosal integrity by ribotoxins: mechanistic implications of environmentally-linked epithelial inflammatory diseases
    Yuseok Moon
    Laboratory of Systems Mucosal Biomodulation, Department of Microbiology and Immunology, Medical Research Institute Pusan National University School of Medicine, Yangsan 626 870, South Korea
    Toxicon 59:192-204. 2012
    ..Since the primary toxic actions of most ribotoxic stress agents are generally recognized to be the functional inhibition of global protein ..
  88. ncbi Cholesterol metabolism is modulated by quercetin in rats
    Liting Zhao
    Medical College of Chinese People s Armed Police Forces, Tianjin 300162, People s Republic of China
    J Agric Food Chem 59:1104-8. 2011
    ..Further studies are needed to investigate the molecular mechanisms and the possible links to the health effects or toxic actions of quercetin.
  89. ncbi Insulin resistance induced by a high-fructose diet potentiates thioacetamide hepatotoxicity
    M Pooranaperundevi
    Department of Biochemistry and Biotechnology, Annamalai University, Annamalai Nagar 608 002, Tamil Nadu, India
    Singapore Med J 51:389-98. 2010
    ..This study investigated the susceptibility of the liver to the toxic actions of thioacetamide (TA) in a rat model of IR, induced by feeding the rats a high-fructose diet (60 g/100 g) for ..
  90. ncbi The significance of the nongenomic pathway in mediating inflammatory signaling of the dioxin-activated Ah receptor to cause toxic effects
    Fumio Matsumura
    Department of Environmental Toxicology, University of California Davis, Davis, CA 95616, USA
    Biochem Pharmacol 77:608-26. 2009
    ..of recent investigations in our laboratory in comparison to already existing evidence on the patterns of toxic actions of dioxin (=TCDD) from other laboratories from a specific viewpoint of elicitation of cellular inflammatory ..
  91. ncbi Modulation of quinolinic and kynurenic acid content in the rat brain: effects of endotoxins and nicotinylalanine
    F Moroni
    Department of Preclinical and Clinical Pharmacology, University of Florence, Italy
    J Neurochem 57:1630-5. 1991
    ..in quinolinic acid may provide a useful approach for studying the role of these electrophysiologically active tryptophan metabolites in brain function and preventing the possible toxic actions of abnormal synthesis of quinolinic acid.
  92. ncbi Redox-modulated xenobiotic action and ROS formation: a mirror or a window?
    G Pagano
    Italian National Cancer Institute, G Pascale Foundation, Naples, Italy
    Hum Exp Toxicol 21:77-81. 2002
    ..Their toxic actions, however, are well-known to be modulated via redox parameters, such as oxygen tension, antioxidants levels, or ..
  93. ncbi In vitro lead-induced cell toxicity and cytoprotective activity of fetal calf serum in human fibroblasts
    Carmen Dominguez
    Biochemistry and Molecular Biology Center, Vall d Hebron Hospitals, Barcelona, Spain
    Mol Cell Biochem 237:47-53. 2002
    ..b>Toxic actions on lysosomal membrane integrity provoked a decrease in neutral red uptake (NRU) which was exposure time-..
  94. ncbi Investigation of systemic bupivacaine toxicity using the in situ perfused working heart-brainstem preparation of the rat
    Anthony E Pickering
    Sir Humphry Davy Department of Anaesthesia, Royal Infirmary, University of Bristol, Bristol BS2 8HW, UK
    Anesthesiology 97:1550-6. 2002
    ..Systemic bupivacaine may affect neural control of the cardiovascular system in addition to having toxic actions on the heart...
  95. ncbi Malonyl-CoA signaling, lipid partitioning, and glucolipotoxicity: role in beta-cell adaptation and failure in the etiology of diabetes
    Marc Prentki
    Molecular Nutrition Unit, Department of Nutrition, University of Montreal, the Centre de Recherche du CHUM, Montreal, Quebec, Canada
    Diabetes 51:S405-13. 2002
    ..Both glucose and fatty acids may cause good/adaptive or evil/toxic actions on the beta-cell, depending on their concentrations and the time during which they are elevated...
  96. ncbi Embryonal cardiotoxicity of the Helicobacter pylori lipopolysaccharide
    M A Panaro
    Department of Human Anatomy and Histology, University of Bari, Policlinico, Piazza, Giulio, Cesare, 1 70124, Bari, Italy
    Curr Drug Targets Immune Endocr Metabol Disord 1:31-44. 2001
    ..ROS are probably responsible for the early toxic actions, while both ROS and NO are likely to be involved in the later degenerative/necrotic effects.
  97. ncbi The eye as a window to inborn errors of metabolism
    B T Poll-The
    Department of Pediatrics Emma Children s Hospital and Laboratory of Genetic Metabolic Diseases, Amsterdam, The Netherlands
    J Inherit Metab Dis 26:229-44. 2003
    ..The occurrence of eye abnormalities in metabolic disorders suggests that they are associated with direct toxic actions, errors of synthetic pathways or deficient energy metabolism...
  98. ncbi 17 Beta-oestradiol attenuates dexamethasone-induced lethal and sublethal neuronal damage in the striatum and hippocampus
    L E Haynes
    School of Biomedical Sciences, The Medical School, Queens Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK
    Neuroscience 120:799-806. 2003
    ..This association may result from the toxic actions of endogenous corticosteroids which can induce apoptosis of hippocampal neurons...
  99. ncbi On the significance of the role of cellular stress response reactions in the toxic actions of dioxin
    Fumio Matsumura
    Department of Environmental Toxicology, University of California, One Shields Avenue, Davis, CA, USA
    Biochem Pharmacol 66:527-40. 2003
    ..The major strategy adopted in analyzing its major signaling pathways is to view the toxic actions of dioxin as the result of the Ah receptor-mediated expression of a major cellular emergency stress response ..
  100. ncbi Mechanisms of pyrethroid neurotoxicity: implications for cumulative risk assessment
    David M Soderlund
    Department of Entomology, New York State Agricultural Experiment Station, Cornell University, Geneva, NY 14456, USA
    Toxicology 171:3-59. 2002
    ..The diverse toxic actions and pharmacological effects of pyrethroids suggest that simple additivity models based on combined actions at ..
  101. ncbi Mechanisms of carvedilol action in human congestive heart failure
    D M Kaye
    Department of Cardiovascular Medicine, Alfred Hospital and Baker Medical Research Institute, Melbourne, Australia
    Hypertension 37:1216-21. 2001
    ..beta2-adrenoceptor-mediated modulation of catecholamine release, antagonism of the receptor-mediated toxic actions of norepinephrine on the myocardium, and favorable effects on myocardial energetics...

Research Grants36

  1. Small Animal Model of HIV Neuropathogenesis in the HAART Era
    Pietro P Sanna; Fiscal Year: 2012
    ..Converging evidence from clinical and laboratory studies suggest the hypothesis that the toxic actions of low-level expression of multiple HIV-1 products are key to persistent central nervous system HIV disease ..
  2. Alcohol-Induced Fatty Liver and Injury in Humanized CYP2E1 Knockin Mice.
    Arthur I Cederbaum; Fiscal Year: 2011
    ..With the novel use of CYP2E1 knockout mice and humanized CYP2E1 knockin mice, a role for CYP2E1 in these toxic actions of alcohol has been defined...
  3. Poly (ADP-Ribose) and AIF in Neuronal Injury
    RAYMOND CHARLES KOEHLER; Fiscal Year: 2013
    ..of additional components of the PAR/AIF signaling complex will lead to new methods to terminate the toxic actions of PAR polymer and AIF and offer innovative therapeutic approaches to treat neurodegenerative diseases and ..
  4. Receptor-based developmental and reproductive toxicity of Superfund chemicals
    David M Ozonoff; Fiscal Year: 2013
    ..chemicals under study are organic compounds of special interest to the SRP Center mandate that initiate their toxic actions by interacting with specific molecules inside cells called receptors...
  5. ApoE4 Structure Correctors as a Therapeutic Approach for Alzheimers Disease
    Robert W Mahley; Fiscal Year: 2013
    ..The focus of our studies is to discover novel drugs targeting the toxic actions of apolipoprotein (apo) E4 to block neurodegeneration in AD...
  6. Amyloid-Lowering Small Molecule AB-Binding Agents in AD
    William E Klunk; Fiscal Year: 2010
    ..shown that this class of compounds possesses anti-aggregation and anti-oxidant effects and protects cells from toxic actions of A?...
  7. The Role of Ubiquitination in Methamphetamine Neurotoxicity (CDA)
    Anna Moszczynska; Fiscal Year: 2012
    ..ubiquitination-mediating E3 ligases (particularly parkin) in regulation of proteins known to be affected by MA toxic actions, and vice versa, namely ubiquitin proteasomal system, mitochondrial electron chain proteins, dopamine ..
  8. Receptor Sites and Antagonists for Paralytic Neurotoxins
    William A Catterall; Fiscal Year: 2010
    ..a- and [unreadable]-scorpion toxins on Na channels, and we will develop therapeutic agents to prevent their toxic actions as well as the toxic actions of mechanistically related peptide neurotoxins from other sources...
  9. Mechanism and Treatment of Manganese Toxicity
    JEROME ALLAN ROTH; Fiscal Year: 2010
    ..Although the neurotoxic mechanisms provoking increased susceptibility of pallidal neurons to the toxic actions of Mn is not fully understood, there is increasing evidence that the excitatory neurotransmitter, glutamate, ..
  10. ION CHANNEL TARGETS FOR CARDIAC GLYCOSIDE ACTIONS
    J Wasserstrom; Fiscal Year: 2000
    ..actions on the sarcolemma and sarcoplasmic reticulum (SR), that contribute to their positive inotropic and/or toxic actions. The purpose of this project is to investigate new subcellular actions of several cardiotonic steroids on ..
  11. NEW PHENYL NUCLEOSIDES AS ANTI-HIV AGENTS
    Shashikant Phadtare; Fiscal Year: 2003
    ..both target and nontarget macromolecules and this may result, at least in part, in the therapeutic as well as toxic actions of the drug...
  12. PHENCYCLIDINE TOXICITY: NEUROPSYCHIATRIC IMPLICATIONS
    John Olney; Fiscal Year: 1992
    ..displays even greater potency than PCP in binding to the PCP receptor and in antagonizing the excitatory and toxic actions of NMDA...
  13. NOVEL ANTI-PCP AGENTS WITH NEUROPROTECTIVE PROPERTIES
    TIEN HUANG; Fiscal Year: 2001
    ..it to bind to different macromolecules and this may account at least in part, for the therapeutic as well as toxic actions of the drug...
  14. Mode of Action of Insecticides: Electrophysiological
    Toshio Narahashi; Fiscal Year: 2004
    ..goal of the proposed study is to elucidate the mechanism by which neuroactive insecticides exert their toxic actions. The specific aims of the proposed renewal application are to elucidate the physiological mechanisms that ..
  15. CHEMICAL PHARMACOLOGY OF MDA AND MDMA
    Arthur Cho; Fiscal Year: 1992
    ..A neuroblastoma based cell line (NG108-15) has been shown to be sensitive to the toxic actions of some of the phenylisopropylamine derivatives...
  16. MECHANISMS OF TROPHIN AND TOXIN ELABORATION BY MICROGLIA
    Stella Elkabes; Fiscal Year: 2001
    ..Delineation of molecular mechanisms underlying microglial activation and elucidation of microglial trophic and toxic actions may provide insights into processes associated with CNS inflammation and injury Attenuation of toxin ..
  17. GENETIC MODEL OF NEURODEGENERATION
    Mel Feany; Fiscal Year: 2003
    ..disease and Alzheimer s disease are dominantly inherited neurodegenerative disorders most likely produced by toxic actions of the encoded gene products...
  18. METABOTROPIC GLUTAMATE RECEPTORS IN NEURODEGENERATION
    Anne Young; Fiscal Year: 1999
    b>Toxic actions of the neurotransmitter, glutamic acid, have been implicated in a number of diseases that effect the brain including stroke, epilepsy, Huntington~s disease, Alzheimer's disease, Parkinson's disease and amyotrophic lateral ..
  19. Environmental Disruption of Uterine Function
    JAMES PRU; Fiscal Year: 2007
    ..hydrocarbons (PAH), derived from the incomplete combustion of fossil fuels and tobacco smoke, elicit their toxic actions on tissues primarily through activation of the aryl hydrocarbon receptor (AHR)...
  20. The Role of Ubiquitination in Methamphetamine Neurotoxicity (CDA)
    Anna Moszczynska; Fiscal Year: 2009
    ..ubiquitination-mediating E3 ligases (particularly parkin) in regulation of proteins known to be affected by MA toxic actions, and vice versa, namely ubiquitin proteasomal system, mitochondrial electron chain proteins, dopamine ..
  21. TOXICOLOGY OF POLYCHLORINATED AZOXY AND AZOBENZENES
    MONG TSENG HSIA; Fiscal Year: 1980
    ..be made to identify the involvement of biologically active metabolites on the molecular level to the observed toxic actions. Emphasis will be placed upon their covalent interaction to cellular macromolecules (DNA, RNA and proteins) in ..
  22. ALCOHOL OXYGEN RADICAL INTERACTIONS AS DETECTED BY ESR
    Arthur Cederbaum; Fiscal Year: 2001
    ..SPECIFIC Aim I is designed to study the role of HER, lipid, and other free radicals in the toxic actions of ethanol and PUFA to cells expressing CYP2El. The major analytical technique to be used is ESR spectroscopy...
  23. COCAINE:PHARMACO-DYNAMIC & KINETIC STUDY IN WKY & SHR
    ING HO; Fiscal Year: 1991
    ..assess, in vivo, specific contributions of dopaminergic neuronal systems to the behavior, cardiovascular and toxic actions of cocaine and norcocaine...
  24. MECHANISM OF ESTROGENICITY OF DDT ANALOGS IN MCG-7 CELLS
    Fumio Matsumura; Fiscal Year: 2001
    ..The PI finally will address the fundamental question of whether c-Neu activation serves as a major gateway in addition to the estrogen receptor for xenobiotics to cause truly estrogenic cellular responses or not. ..
  25. Divalent Metal Transporter: Role in Manganese Toxicity
    JEROME ROTH; Fiscal Year: 2004
    ....
  26. Insecticide Action at the Local Anesthetic Receptor
    David M Soderlund; Fiscal Year: 2011
    ..This research will provide new insight into the structure of the local anesthetic receptor and its role in the neurotoxic actions of PTIs. ..
  27. Oxidative Stress, Mitochondrial Dysfunction and Aging
    Enrique Cadenas; Fiscal Year: 2009
    ..These mechanisms play a critical role in the progression of the aging process and may precede or modulate age-related oxidative- and nitrosative damages. ..
  28. MOLECULAR MECHANISMS OF HEXACARBON-INDUCED AXON ATROPHY
    RICHARD LOPACHIN; Fiscal Year: 2009
    ..Understanding the role and mechanism of axon atrophy in solvent neurotoxicity has broad-based implications for human occupational health and risk assessment. ..
  29. MECHANISMS OF CADMIUM TOXICITY IN EPITHELIAL CELLS
    WALTER PROZIALECK; Fiscal Year: 2007
    ..Furthermore, the results of these studies could have more general implications regarding the mechanisms by which toxic substances affect living organisms. ..
  30. XIIIth Biennial Meeting of the Society for Free Radical Research International
    Enrique Cadenas; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  31. Mitochondrial oxidative damage in dopaminergic cells
    Enrique Cadenas; Fiscal Year: 2005
    ..Understanding of the nature of the putative mechanisms is deemed to be an indispensable step in developing therapeutic interventions. ..
  32. Ethanol Effects of SR Ca2+ Release in Cardiac Myocytes
    J Wasserstrom; Fiscal Year: 2005
    ....