surface active agents

Summary

Summary: Agents that modify interfacial tension of water; usually substances that have one lipophilic and one hydrophilic group in the molecule; includes soaps, detergents, emulsifiers, dispersing and wetting agents, and several groups of antiseptics.

Top Publications

  1. ncbi Recent applications of biosurfactants as biological and immunological molecules
    Swaranjit Singh Cameotra
    IMTECH, Sector 39A, Chandigarh 160036, India
    Curr Opin Microbiol 7:262-6. 2004
  2. ncbi Effect of CTAB and SDS micelles on the excited state equilibria of some indole probes
    Neera Sharma
    Department of Chemistry, University of Delhi, Delhi, India
    Spectrochim Acta A Mol Biomol Spectrosc 68:927-41. 2007
  3. ncbi Investigating the location of propyl gallate at surfaces and its chemical microenvironment by (1)H NMR
    Anja Heins
    Institute of Human Nutrition and Food Science, University of Kiel, Heinrich Hecht Platz 10, 24118 Kiel, Germany
    Lipids 42:561-72. 2007
  4. ncbi The location of phenolic antioxidants and radicals at interfaces determines their activity
    Anja Heins
    Institute of Human Nutrition and Food Science, University of Kiel, Heinrich Hecht Platz 10, 24118 Kiel, Germany
    Lipids 42:573-82. 2007
  5. ncbi Surface chemistry and rheology of polysulfobetaine-coated silica
    Pierre Starck
    Department of Chemical and Biomolecular Engineering, University of Melbourne, Parkville, Victoria 3010, Australia
    Langmuir 23:7587-93. 2007
  6. ncbi Environmental applications for biosurfactants
    Catherine N Mulligan
    Department Building, Civil and Environmental Engineering, Concordia University, 1455 de Maisonneuve Boulevard W, Montreal, Quebec, Canada, H3G 1M8
    Environ Pollut 133:183-98. 2005
  7. ncbi Cationic lipids and surfactants as antifungal agents: mode of action
    Débora B Vieira
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, CP 26077, Avenida Lineu Prestes 748 Butantã, CEP 05513 970 Sao Paulo, Brazil
    J Antimicrob Chemother 58:760-7. 2006
  8. ncbi Potential applications of microbial surfactants in biomedical sciences
    Pooja Singh
    Institute of Microbial Technology, Sector 39 A, Chandigarh 160036, India
    Trends Biotechnol 22:142-6. 2004
  9. ncbi Comparison of methods to detect biosurfactant production by diverse microorganisms
    Noha H Youssef
    Department of Botany and Microbiology, University of Oklahoma, 770 Van Vleet Oval Norman, OK 73019, USA
    J Microbiol Methods 56:339-47. 2004
  10. pmc Swarming of Pseudomonas aeruginosa is dependent on cell-to-cell signaling and requires flagella and pili
    T Kohler
    Department of Genetics and Microbiology, University Medical Center, Sciences III, University of Geneva, CH 1211 Geneva 4, Switzerland
    J Bacteriol 182:5990-6. 2000

Detail Information

Publications258 found, 100 shown here

  1. ncbi Recent applications of biosurfactants as biological and immunological molecules
    Swaranjit Singh Cameotra
    IMTECH, Sector 39A, Chandigarh 160036, India
    Curr Opin Microbiol 7:262-6. 2004
    ..Here, we discuss the role and applications of biosurfactants (mainly glycolipids and lipopeptides) focusing on medicinal and therapeutic perspectives...
  2. ncbi Effect of CTAB and SDS micelles on the excited state equilibria of some indole probes
    Neera Sharma
    Department of Chemistry, University of Delhi, Delhi, India
    Spectrochim Acta A Mol Biomol Spectrosc 68:927-41. 2007
    ..The observation about increase in pK(a)(*) values in SDS and decrease in CTAB compared to pure water for various equilibria is consistent with the pseudophase ion-exchange (PIE) model...
  3. ncbi Investigating the location of propyl gallate at surfaces and its chemical microenvironment by (1)H NMR
    Anja Heins
    Institute of Human Nutrition and Food Science, University of Kiel, Heinrich Hecht Platz 10, 24118 Kiel, Germany
    Lipids 42:561-72. 2007
    ....
  4. ncbi The location of phenolic antioxidants and radicals at interfaces determines their activity
    Anja Heins
    Institute of Human Nutrition and Food Science, University of Kiel, Heinrich Hecht Platz 10, 24118 Kiel, Germany
    Lipids 42:573-82. 2007
    ..The reverse trend was found in the presence of Fremy's radical being located in the hydrated area of the micelles...
  5. ncbi Surface chemistry and rheology of polysulfobetaine-coated silica
    Pierre Starck
    Department of Chemical and Biomolecular Engineering, University of Melbourne, Parkville, Victoria 3010, Australia
    Langmuir 23:7587-93. 2007
    ..At low salt concentrations, the polymer is barely soluble and more densely adsorbed. This produces less stable and more viscous solutions, which we attribute to attractive interactions between the adsorbed polymer layers...
  6. ncbi Environmental applications for biosurfactants
    Catherine N Mulligan
    Department Building, Civil and Environmental Engineering, Concordia University, 1455 de Maisonneuve Boulevard W, Montreal, Quebec, Canada, H3G 1M8
    Environ Pollut 133:183-98. 2005
    ..As most of the research until now has been performed with rhamnolipids, other biosurfactants need to be investigated as they may have more promising properties...
  7. ncbi Cationic lipids and surfactants as antifungal agents: mode of action
    Débora B Vieira
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, CP 26077, Avenida Lineu Prestes 748 Butantã, CEP 05513 970 Sao Paulo, Brazil
    J Antimicrob Chemother 58:760-7. 2006
    ..To determine the mechanism of antimicrobial action for cationic lipid dioctadecyldimethylammonium bromide (DODAB) and hexadecyltrimethylammonium bromide (CTAB) against Candida albicans...
  8. ncbi Potential applications of microbial surfactants in biomedical sciences
    Pooja Singh
    Institute of Microbial Technology, Sector 39 A, Chandigarh 160036, India
    Trends Biotechnol 22:142-6. 2004
    ..Here, we discuss some of the new and exciting applications and related developments of various microbial surfactants in the field of biomedical sciences...
  9. ncbi Comparison of methods to detect biosurfactant production by diverse microorganisms
    Noha H Youssef
    Department of Botany and Microbiology, University of Oklahoma, 770 Van Vleet Oval Norman, OK 73019, USA
    J Microbiol Methods 56:339-47. 2004
    ..The large number of false negatives and positives obtained with the blood agar lysis method and its poor correlation to surface tension (rs = -0.15) demonstrated that it is not a reliable method to detect biosurfactant production...
  10. pmc Swarming of Pseudomonas aeruginosa is dependent on cell-to-cell signaling and requires flagella and pili
    T Kohler
    Department of Genetics and Microbiology, University Medical Center, Sciences III, University of Geneva, CH 1211 Geneva 4, Switzerland
    J Bacteriol 182:5990-6. 2000
    ..Evidence is presented for rhamnolipids being the actual surfactant involved in swarming motility, which explains the involvement of the cell-to-cell signaling circuitry of P. aeruginosa in this type of surface motility...
  11. ncbi Coil-globule transition of DNA molecules induced by cationic surfactants: a dynamic light scattering study
    Rita S Dias
    Departamento de Quimica, Universidade de Coimbra, 3004 535 Coimbra, Portugal
    J Phys Chem B 109:10458-63. 2005
    ..Furthermore, it allows the study of molecules which are too small to be visualized by fluorescence microscopy...
  12. pmc Vaginal microbicides: detecting toxicities in vivo that paradoxically increase pathogen transmission
    Richard A Cone
    Mucosal Protection Laboratory, Dept of Biophysics, Johns Hopkins University, Baltimore, MD 21218, USA
    BMC Infect Dis 6:90. 2006
    ....
  13. pmc Rhamnolipid stimulates uptake of hydrophobic compounds by Pseudomonas aeruginosa
    Wouter H Noordman
    Department of Biochemistry, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, 9747 AG Groningen, The Netherlands
    Appl Environ Microbiol 68:4502-8. 2002
    ..These results indicate that an energy-dependent system is present in P. aeruginosa strain UG2 that mediates fast uptake of hydrophobic compounds in the presence of rhamnolipid...
  14. ncbi Long-circulating and target-specific nanoparticles: theory to practice
    S M Moghimi
    Molecular Targeting and Polymer Toxicology Group, School of Pharmacy and Biomolecular Sciences, University of Brighton, Brighton, United Kingdom
    Pharmacol Rev 53:283-318. 2001
    ..With regard to the targeting issues, attention is particularly focused on the importance of physiological barriers and disease states...
  15. ncbi Interleukin (IL)-1, IL-6, and IL-8 predict mucosal toxicity of vaginal microbicidal contraceptives
    R N Fichorova
    Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Biol Reprod 71:761-9. 2004
    ..The described evaluation system is a valuable tool in identifying novel vaginal contraceptive microbicides, selecting out candidates that may enhance, rather than decrease, HIV transmission...
  16. ncbi Refolding SDS-denatured proteins by the addition of amphipathic cosolvents
    Catherine Michaux
    Division of Cancer Genomics and Proteomics, Ontario Cancer Institute, 101 College Street, Toronto, Ontario, Canada
    J Mol Biol 375:1477-88. 2008
    ..MPD and related cosolvents can modulate the denaturing properties of SDS, and we describe a simple and effective method to recover refolded, active protein from the SDS-denatured state...
  17. ncbi Biosurfactant production by antarctic facultative anaerobe Pantoea sp. during growth on hydrocarbons
    Evgenia Vasileva-Tonkova
    Bulgarian Academy of Sciences, The Stephan Angeloff Institute of Microbiology, Sofia, Bulgaria
    Curr Microbiol 54:136-41. 2007
    ..According to the results, the Antarctic biosurfactant-producing strain Pantoea sp. A-13 appears to be valuable source for application in accelerated environmental bioremediation...
  18. ncbi Control of the internal structure of MLO-based isasomes by the addition of diglycerol monooleate and soybean phosphatidylcholine
    Anan Yaghmur
    Institute of Chemistry, University of Graz, A 8010 Graz, Austria, and Nestle Research Center, Lausanne, Switzerland
    Langmuir 22:9919-27. 2006
    ....
  19. pmc Multiple roles of biosurfactants in structural biofilm development by Pseudomonas aeruginosa
    Sünje Johanna Pamp
    Centre for BioScience Technology, BioCentrum DTU, Building 301, The Technical University of Denmark, DK 2800 Lyngby, Denmark
    J Bacteriol 189:2531-9. 2007
    ..aeruginosa biofilms demonstrated that the wild-type and rhlA and pilA mutant strains formed distinct subpopulations on top of each other dependent on their ability to migrate and produce biosurfactants...
  20. ncbi Rat enterocytes secrete SLPs containing alkaline phosphatase and cubilin in response to corn oil feeding
    Akhtar Mahmood
    Dept of Medicine, Washington Univ School of Medicine, 660 S Euclid Ave, St Louis, MO 63110 1010, USA
    Am J Physiol Gastrointest Liver Physiol 285:G433-41. 2003
    ..Possible roles for cubilin in intracellular SLP include facilitating movement of the lipid droplet through the cell and binding to the basolateral membrane before reverse endocytosis...
  21. ncbi Rhamnolipid-biosurfactant permeabilizing effects on gram-positive and gram-negative bacterial strains
    A V Sotirova
    Department of Microbial Biochemistry and Biosynthesis, The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, Sofia 1113, Bulgaria
    Curr Microbiol 56:639-44. 2008
    ....
  22. pmc Modulation of KvAP unitary conductance and gating by 1-alkanols and other surface active agents
    Rocio K Finol-Urdaneta
    Hotchkiss Brain Institute and Department of Physiology and Pharmacology, University of Calgary, Alberta, Canada
    Biophys J 98:762-72. 2010
    ..Controversy continues about whether bilayer restructuring is relevant to the modulatory effects of these surface active agents (SAAs)...
  23. ncbi Molecular mechanism and thermodynamics study of plasmid DNA and cationic surfactants interactions
    De Min Zhu
    Biologics and Vaccines, Pharmaceutical Research and Development, Merck Research Laboratories, Merck and Co, Inc, West Point, Pennsylvania 19486, USA
    Langmuir 22:3735-43. 2006
    ....
  24. ncbi Role of phenanthrene in rhamnolipid production by P. putida in different media
    A Martínez-Toledo
    Centro de Investigacion y Estudios Avanzados del IPN, Av IPN No 2508, Col San Pedro Zacatenco, CP 07360, Mexico, DF
    Environ Technol 27:137-42. 2006
    ..The polar fraction (Rhamnose) in media 1, 3, 7 and 8 with phenanthrene was c.a 100%, in contrast to those without phenanthrene where this fraction was undetectable...
  25. ncbi Biosurfactant production in sugar beet molasses by some Pseudomonas spp
    Dilsad Onbasli
    Deparment of Biology, Faculty of Science and Arts, Kastamonu University, Kastamonu, Turkey
    J Environ Biol 30:161-3. 2009
    ..was compared, no significant difference in amount of production was seen. These studies show that the waste product from sugar industry may be suggested for important biotechnological processes such as rhamnolipid production...
  26. pmc Latherin: a surfactant protein of horse sweat and saliva
    Rhona E McDonald
    Ecology and Evolutionary Biology, Faculty of Biomedical and Life Sciences, University of Glasgow, Glasgow, United Kingdom
    PLoS ONE 4:e5726. 2009
    ....
  27. ncbi Structural and physicochemical characterization of crude biosurfactant produced by Pseudomonas aeruginosa SP4 isolated from petroleum-contaminated soil
    Orathai Pornsunthorntawee
    The Petroleum and Petrochemical College, Chulalongkorn University, Bangkok, Thailand
    Bioresour Technol 99:1589-95. 2008
    ..The crude biosurfactant also formed stable water-in-oil microemulsions with crude oil and various types of vegetable oils, but not with short-chain hydrocarbons...
  28. ncbi Effect of vehicles and enhancers on the topical delivery of cyclosporin A
    Hongzhuo Liu
    School of Pharmaceutics, Shenyang Pharmaceutical University, Wen Hua RD NO 103, Shenyang 110016, People s Republic of China
    Int J Pharm 311:182-6. 2006
    ..The present study suggests that the suspension of 40% ethanol containing 0.5% drug can more effectively enhance the topical delivery of CysA after skin pre-treatment with 10% menthol or 0.05% SLS...
  29. pmc Amphiphilic blockers punch through a mutant CLC-0 pore
    Xiao Dong Zhang
    Center for Neuroscience and Department of Neurology, University of California, Davis, CA 95618, USA
    J Gen Physiol 133:59-68. 2009
    ..Furthermore, a minimal CPA-dissociation rate at a voltage 80 mV more negative than the Cl(-) reversal potential suggests that the outward blocker movement through the CLC-0 pore is more difficult than the inward movement...
  30. ncbi Rhamnolipid surfactants: an update on the general aspects of these remarkable biomolecules
    Marcia Nitschke
    Department of Biochemistry and Microbiology, Institute of Biological Sciences, São Paulo State University UNESP Rio Claro, Av 24 A, 1515 Bela Vista CEP 13506 900, Caixa Postal 199, Rio Claro, SP, Brazil
    Biotechnol Prog 21:1593-600. 2005
    ..Carbohydrate-rich substrates generated low rhamnolipid levels, whereas oils and lipid-rich wastes have shown excellent potential as alternative carbon sources...
  31. ncbi Insights on polymer surfactant complex structures during the binding of surfactants to polymers as measured by equilibrium and structural techniques
    Kam C Tam
    School of Mechanical and Aerospace Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798
    Chem Soc Rev 35:693-709. 2006
    ..We describe how the basic foundations, which are prerequisite to characterize a given polymer/surfactant system are evaluated together with information on the binding mechanism and structure derived from several methodologies...
  32. pmc Two crystal structures of Trichoderma reesei hydrophobin HFBI--the structure of a protein amphiphile with and without detergent interaction
    Johanna Hakanpaa
    Department of Chemistry, University of Joensuu, Finland
    Protein Sci 15:2129-40. 2006
    ....
  33. ncbi Natural roles of biosurfactants
    E Z Ron
    Department of Molecular Microbiology and Biotechnology, Tel Aviv University, Ramat Aviv, Israel
    Environ Microbiol 3:229-36. 2001
    ..Recent experiments indicate that a high-molecular-weight bioemulsifier that coats the bacterial surface can be transferred horizontally to other bacteria, thereby changing their surface properties and interactions with the environment...
  34. ncbi Phosphatidylcholine embedded micellar systems: enhanced permeability through rat skin
    Aviram Spernath
    Casali Institute of Applied Chemistry, The Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
    J Colloid Interface Sci 318:421-9. 2008
    ..Moreover, the combination of PC with HECO40 improved the permeation rate (P) and shortened the lag-time (T(L))...
  35. pmc Molecular self-assembly of surfactant-like peptides to form nanotubes and nanovesicles
    Sylvain Vauthey
    Center for Biomedical Engineering, 56 341, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139 4307, USA
    Proc Natl Acad Sci U S A 99:5355-60. 2002
    ..Studies of peptide surfactant molecules have significant implications in the design of nonlipid biological surfactants and the understanding of the complexity and dynamics of the self-assembly processes...
  36. pmc Reversible condensation of DNA using a redox-active surfactant
    Melissa E Hays
    Department of Chemical and Biological Engineering, University of Wisconsin, 1415 Engineering Drive, Madison, Wisconsin 53706 1691, USA
    Langmuir 23:5609-14. 2007
    ..These results provide guidance for the design of surfactant systems that permit active control of DNA-surfactant interactions...
  37. ncbi Extracellular production of a glycolipid biosurfactant, mannosylerythritol lipid, by Candida sp. SY16 using fed-batch fermentation
    Hee Sik Kim
    Environmental Biotechnology Laboratory, Korea Research Institute of Bioscience and Biotechnology, Yusong, Daejon, South Korea
    Appl Microbiol Biotechnol 70:391-6. 2006
    ..Among the investigated culture systems, the highest MEL-SY16 production and volumetric production rate were achieved with fed-batch fermentation...
  38. ncbi Effects of an amphipathic alpha-helical peptide on lateral pressure and water penetration in phosphatidylcholine and monoolein mixed membranes
    Tomoari Kamo
    Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606 8501, Japan
    J Phys Chem B 110:24987-92. 2006
    ..This preferential binding to the MO-containing membranes is presumably ascribed to the propensity of 18A to reduce the membrane strain...
  39. pmc Designer short peptide surfactants stabilize G protein-coupled receptor bovine rhodopsin
    Xiaojun Zhao
    Center for Biomedical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139 4307, USA
    Proc Natl Acad Sci U S A 103:17707-12. 2006
    ..These peptide surfactants are simple, versatile, effective, and affordable. They represent a designer molecular nanomaterial for use in studies of diverse elusive membrane proteins...
  40. ncbi Dynamic surface tension behavior in a photoresponsive surfactant system
    Bradley A Cicciarelli
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Langmuir 23:4753-64. 2007
    ..These changes are consistent with proposed conformations of the adsorbed surfactant and with monolayer studies performed with a Langmuir film balance...
  41. pmc Comparative in vitro sensitivities of human immune cell lines, vaginal and cervical epithelial cell lines, and primary cells to candidate microbicides nonoxynol 9, C31G, and sodium dodecyl sulfate
    Fred C Krebs
    Department of Microbiology and Immunology, The Pennsylvania State University, College of Medicine, Hershey, Pennsylvania 17033, USA
    Antimicrob Agents Chemother 46:2292-8. 2002
    ....
  42. ncbi Oxygen-controlled biosurfactant production in a bench scale bioreactor
    Frederico de Araujo Kronemberger
    Programa de Engenharia Quimica, Instituto Alberto Luiz Coimbra de Pós graduação e Pesquisa de Engenharia, Universidade Federal do Rio de Janeiro, Centro de Tecnologia, Rio de Janeiro, Brazil
    Appl Biochem Biotechnol 147:33-45. 2008
    ..0 mgO(2)/g(DW) h. Then, when the exponential growth phase begins, there is a rise in this rate. After that, the SOUR reduces to about 20.0 mgO(2)/g(DW) h. The carbon source consumption is linear during the whole process...
  43. doi Biosurfactant production by Rhodococcus erythropolis grown on glycerol as sole carbon source
    Elisa M P Ciapina
    Departamento de Bioquimica, Universidade Federal do Rio de Janeiro, Centro de Tecnologia, Bloco E, CEP 21949 900, Rio de Janeiro, RJ, Brasil
    Appl Biochem Biotechnol 131:880-6. 2006
    ..The use of glycerol rather than what happens with hydrophobic carbon source allowed the release of the biosurfactant, originally associated to the cell wall...
  44. ncbi Novel surfactant proteins are involved in the structure and stability of foam nests from the frog Leptodactylus vastus
    Denise Cavalcante Hissa
    Departamento de Biologia, Universidade Federal do Ceara, Av Humberto Monte 2775 Campus Pici, Bloco 909, Fortaleza, Brazil
    J Exp Biol 211:2707-11. 2008
    ..This protein did not show any match to known proteins or structures, which suggests that it belongs to a new class of surfactant protein...
  45. pmc Blocking pore-open mutants of CLC-0 by amphiphilic blockers
    Xiao Dong Zhang
    Center for Neuroscience and Department of Neurology, University of California, Davis, CA 95618, USA
    J Gen Physiol 133:43-58. 2009
    ....
  46. ncbi Enhanced crude oil biodegradation and rhamnolipid production by Pseudomonas stutzeri strain G11 in the presence of Tween-80 and Triton X-100
    Gokcen Yuvali Celik
    Department of Biology, Faculty of Science and Arts, Nigde University, 51200 Campus Nigde, Turkey
    J Environ Biol 29:867-70. 2008
    ..These results suggest that surfactants have improved both crude oil degradation and rhamnolipid production and the degradation rates have depended very much on the chemical structure of surfactants...
  47. pmc Salmonella enterica serovar typhimurium swarming mutants with altered biofilm-forming abilities: surfactin inhibits biofilm formation
    J R Mireles
    Section of Molecular Genetics and Microbiology and Institute of Cellular and Molecular Biology, University of Texas at Austin, 78712, USA
    J Bacteriol 183:5848-54. 2001
    ..We report that surfactin inhibits biofilm formation of wild-type S. enterica grown either in polyvinyl chloride microtiter wells or in urethral catheters. Other bio- and chemical surfactants tested had similar effects...
  48. ncbi High- and low-molecular-mass microbial surfactants
    E Rosenberg
    Department of Molecular Microbiology and Biotechnology, Tel Aviv University, Ramat Aviv, Israel
    Appl Microbiol Biotechnol 52:154-62. 1999
    ....
  49. pmc Regulation of sodium channel function by bilayer elasticity: the importance of hydrophobic coupling. Effects of Micelle-forming amphiphiles and cholesterol
    Jens A Lundbaek
    Novo Nordisk A S, Måløv, Denmark
    J Gen Physiol 123:599-621. 2004
    ..These results provide strong support for the notion that bilayer-protein hydrophobic coupling allows the bilayer elastic properties to regulate membrane protein function...
  50. ncbi Interaction of membrane proteins and lipids with solubilizing detergents
    M le Maire
    Unite de recherche Associée 2096 Centre National de la Recherche Scientifique et Commissariat a l Energie Atomique, Cedex, France
    Biochim Biophys Acta 1508:86-111. 2000
    ..Finally, we briefly discuss the use of techniques such as analytical ultracentrifugation, size exclusion chromatography, and mass spectrometry relevant for the structural investigation of detergent solubilized membrane proteins...
  51. ncbi Isolation, characterization, and expression in Escherichia coli of the Pseudomonas aeruginosa rhlAB genes encoding a rhamnosyltransferase involved in rhamnolipid biosurfactant synthesis
    U A Ochsner
    Institute for Biotechnology, Swiss Federal Institute of Technology, ETH Honggerberg, Zurich
    J Biol Chem 269:19787-95. 1994
    ..The controlled expression of the rhlAB genes in Escherichia coli led to the formation of active rhamnosyltransferase. This provides direct evidence for the fact that the rhamnosyltransferase encoding genes have been identified...
  52. ncbi Dynamics of protein and mixed protein/surfactant adsorption layers at the water/fluid interface
    R Miller
    , Golm, Germany
    Adv Colloid Interface Sci 86:39-82. 2000
    ....
  53. ncbi Pseudomonas aeruginosa rhamnolipids disperse Bordetella bronchiseptica biofilms
    Yasuhiko Irie
    Department of Microbiology, University of Pennsylvania School of Medicine, 201C Johnson Pavilion, 3610 Hamilton Walk, Philadelphia, PA 19104 6084, USA
    FEMS Microbiol Lett 250:237-43. 2005
    ..bronchiseptica biofilms by rhamnolipids secreted from Pseudomonas aeruginosa. This suggests that biosurfactants such as rhamnolipids may be utilized as antimicrobial agents for removing Bordetella biofilms...
  54. ncbi Biochemical characterization and surfactant properties of horse allergens
    H Goubran Botros
    Unite d Immuno Allergie, Institut Pasteur, Paris France
    Eur J Biochem 268:3126-36. 2001
    ..Relationship between a property such as this, involving oriented hydrophobic patches of a molecule and allergenicity, is addressed...
  55. pmc Comparative study of mechanisms of herpes simplex virus inactivation by sodium lauryl sulfate and n-lauroylsarcosine
    Jocelyne Piret
    Centre de Recherche en Infectiologie, Universite Laval, Quebec, Quebec, Canada
    Antimicrob Agents Chemother 46:2933-42. 2002
    ....
  56. ncbi High-performance liquid chromatography method for the characterization of rhamnolipid mixtures produced by pseudomonas aeruginosa UG2 on corn oil
    J C Mata-Sandoval
    Department of Civil and Environmental Engineering, University of Maryland at College Park, 20742, USA
    J Chromatogr A 864:211-20. 1999
    ....
  57. pmc A broad-spectrum microbicide with virucidal activity against sexually transmitted viruses
    M K Howett
    Department of Microbiology and Immunology, M S Hershey Medical Center, Pennsylvania State University College of Medicine 17033, USA
    Antimicrob Agents Chemother 43:314-21. 1999
    ..This is the first report of a microbicidal surfactant that will inactivate papillomaviruses. We propose that SDS is now a candidate microbicide for formulation and testing with humans...
  58. pmc Adsorption of frog foam nest proteins at the air-water interface
    Alan Cooper
    Department of Chemistry, University of Glasgow, Glasgow G12 8QQ, Scotland, UK
    Biophys J 88:2114-25. 2005
    ....
  59. ncbi Principles for microscale separations based on redox-active surfactants and electrochemical methods
    C A Rosslee
    Department of Chemical Engineering, University of Wisconsin, Madison 53706-1691, USA
    Anal Chem 73:4808-14. 2001
    ..When used for purification, these principles provide separation of surfactant and product...
  60. ncbi Determination of critical micelle concentration of surfactants by capillary electrophoresis
    Ching Erh Lin
    Department of Chemistry, National Taiwan University, Taipei, Taiwan
    J Chromatogr A 1037:467-78. 2004
    ..In addition, difficulties and uncertainty, as well as misconceptions that may arise in the CMC determination are discussed...
  61. ncbi The effect of cholesterol on the solubilization of phosphatidylcholine bilayers by the non-ionic surfactant Triton X-100
    E Schnitzer
    Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Chem Phys Lipids 135:69-82. 2005
    ..Similarly, cholesterol did not affect significantly the rate of size growth of DPPC bilayers at all temperatures, but reduced the rate of solubilization at 4 degrees C...
  62. ncbi Adsorption and aggregation properties of heterogemini surfactants containing a quaternary ammonium salt and a sugar moiety
    Kanae Nyuta
    Department of Applied Chemistry, Faculty of Science, Tokyo University of Science, 1 3 Kagurazaka, Shinjuku ku, Tokyo 162 8601, Japan
    Langmuir 22:9187-91. 2006
    ....
  63. ncbi Solubilization of valsartan by aqueous glycerol, polyethylene glycol and micellar solutions
    C J Mbah
    DMI Inc, 86 N Main Street, Wharton, NJ 07885, USA
    Pharmazie 61:322-4. 2006
    ..The effect of propylene glycol on the solubility of valsartan in a 2% w/v polysorbate-80 solution was also investigated and was found that propylene glycol decreased the solubilizing power of polysorbate-80 at the concentrations studied...
  64. ncbi Spontaneous transfer of phospholipid-coated oil-in-oil and water-in-oil micro-droplets through an oil/water interface
    Ayako Yamada
    Department of Physics, Graduate School of Science, Kyoto University, Kyoto 606 8502, Japan
    Langmuir 22:9824-8. 2006
    ..We found that, in both cases, micro-droplets spontaneously transferred from the oil phase to the water phase. O/O micro-droplets transformed into oil-in-water micro-droplets, while W/O micro-droplets led to the formation of liposomes...
  65. ncbi Enhanced aqueous solubilization of tetrachloroethylene by a rhamnolipid biosurfactant
    Joseph S Clifford
    Department of Chemical Engineering, University of Waterloo, Waterloo, Ontario, Canada, N2L 3G1
    J Colloid Interface Sci 305:361-5. 2007
    ..2 g(PCE)/g(rhamnolipid) was determined and through this mechanism the biosurfactant significantly improved the apparent aqueous solubility of PCE...
  66. ncbi Effect of the electrolyte concentration on cation binding in aqueous surfactant solutions
    Anna Jakubowska
    Department of Physical Chemistry, Adam Mickiewicz University, Grunwaldzka 6, 60780 Poznan, Poland
    Chemphyschem 7:2312-8. 2006
    ..Besides, specific ion effects (Hofmeister effects) are considered for 1:1 electrolytes...
  67. ncbi Can linear micelles bridge between two surfaces?
    A B Jódar-Reyes
    Departmento de Fisica, Facultad de Veterinaria, Universidad de Extremadura, Avda de la Universidad s n, Caceres, Spain
    J Phys Chem B 110:18415-23. 2006
    ..The depletion mechanism is only expected for systems with extremely hydrophobic and with very hydrophilic particles...
  68. pmc Thermodynamics of unfolding of an integral membrane protein in mixed micelles
    Pankaj Sehgal
    Department of Life Sciences, Aalborg University, DK 9000 Aalborg, Denmark
    Protein Sci 15:890-9. 2006
    ..Thus the thermodynamic behavior of membrane proteins appears to be intimately connected to their detergent-binding properties...
  69. ncbi Novel design of osmotic chitosan capsules characterized by asymmetric membrane structure for in situ formation of delivery orifice
    Gen Ming Wang
    Department of Internal Medicine, Shin Kong Wu Ho Su Memorial Hospital, 95 Wenchang Road, Taipei, Taiwan, ROC
    Int J Pharm 319:71-81. 2006
    ....
  70. ncbi Ultrafast energy transfer in water-AOT reverse micelles
    Dan Cringus
    Department of Physical Chemistry, Zernike Institute for Advanced Materials, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands
    J Phys Chem B 111:14193-207. 2007
    ....
  71. ncbi A molecular dynamics study of free energy of micelle formation for sodium dodecyl sulfate in water and its size distribution
    Noriyuki Yoshii
    Institute for Molecular Science, Myodaiji, Okazaki 444 8585, Japan
    J Chem Phys 124:184901. 2006
    ..The distribution showed a rather sharp peak, indicating that the size is almost a monodisperse one. The size is likely to be insensitive to the total concentration of the surfactant...
  72. ncbi Shape and position of 4-aminophthalimide (4-AP) time-resolved emission spectra (TRES) versus sodium dodecyl sulfate sds concentration in micellar solutions: the partitioning of 4-AP in the micellar phase and in water surrounding the micelles
    Andrzej Maciejewski
    Center for Ultrafast Laser Spectroscopy and Department of Physics, Adam Mickiewicz University, Umultowska 85, 61 614 Poznan, Poland
    J Phys Chem B 109:9422-31. 2005
    ..In connection with our earlier results and literature data, it has been concluded that the concentration of the water solubilized in micelles is the main factor determining the rate and character of these changes...
  73. ncbi Adsorption of cationic monomeric and gemini surfactants on montmorillonite and adsolubilization of vitamin E
    Kenichi Sakai
    Department of Pure and Applied Chemistry, Faculty of Science and Technology, Tokyo University of Science, Noda, Chiba, Japan
    J Oleo Sci 57:423-9. 2008
    ....
  74. ncbi Combining precision spin-probe partitioning with time-resolved fluorescence quenching to study micelles. Application to micelles of pure lysomyristoylphosphatidylcholine (LMPC) and LMPC mixed with sodium dodecyl sulfate
    Miroslav Peric
    Department of Physics and Astronomy and The Center for Supramolecular Studies, California State University at Northridge, Northridge, CA 91330 8268, United States
    Chem Phys Lipids 142:1-13. 2006
    ..Well-defined micellar substrates, in terms of their physicochemical properties, may improve the studies of protein structure and enzyme kinetics...
  75. ncbi Importance of bacterial surface properties to control the stability of emulsions
    Mai Huong Ly
    Laboratoire de Microbiologie UMR UB INRA 1232, ENSBANA, 1, Esplanade Erasme 21000 Dijon, France
    Int J Food Microbiol 112:26-34. 2006
    ..In addition, these results suggest that the interactions between bacteria and other food components can influence the position of bacteria in food matrixes...
  76. ncbi Premicellar and micelle formation behavior of dye surfactant ion pairs in aqueous solutions: deprotonation of dye in ion pair micelles
    Biren Gohain
    Department of Chemical Sciences, Tezpur University, Napaam, Tezpur 784 028, India
    J Colloid Interface Sci 323:395-402. 2008
    ..At concentrations above the CMC of the cationic surfactant the dye is solubilized in normal micelles and the monolayer at the air-water interface consists of the cationic surfactant alone even in the presence of the dyes...
  77. ncbi Cationic ester-containing gemini surfactants: adsorption at tailor-made surfaces monitored by SPR and QCM
    A R Tehrani-Bagha
    Department of Chemical and Biological Engineering, Chalmers University of Technology, SE 412 96 Goteborg, Sweden
    Langmuir 24:6140-5. 2008
    ..The adsorption, as measured by both methods, was found to follow closely the Langmuir adsorption model...
  78. doi Hierarchically structured microparticles formed by interfacial instabilities of emulsion droplets containing amphiphilic block copolymers
    Jintao Zhu
    Department of Polymer Science and Engineering, University of Massachusetts, Amherst, MA 01003, USA
    Angew Chem Int Ed Engl 47:2113-6. 2008
  79. ncbi Catanionic systems from conversion of nucleotides into nucleo-lipids
    Ruggero Angelico
    Consorzio per lo sviluppo dei Sistemi a Grande Interfase CSGI c o Università del Molise DISTAAM, v De Sanctis, I 86100 Campobasso, Italy
    Langmuir 24:2348-55. 2008
    ..This system as a whole represents a potential experimental model where the effect of both intermolecular interactions and self-association processes can be investigated by tuning the type of nucleobases in the reaction mixtures...
  80. ncbi Solubilization of 5-methoxy tryptamine molecular probes in CTAB and SDS micelles: a cmc and binding constant study
    Neera Sharma
    Department of Chemistry, University of Delhi, Delhi 110007, India
    Spectrochim Acta A Mol Biomol Spectrosc 69:748-56. 2008
    ..Higher value of binding constant and lower polarity of the binding sites justify 5-NMT as a better binding probe as the two methyl groups make the molecule more hydrophobic and drag it to the interior of both the micelles...
  81. ncbi Effect of long-chain alcohols on SDS partitioning to the oil/water interface of emulsions and on droplet size
    Monica A James-Smith
    Center for Surface Science and Engineering, University of Florida, Gainesville, FL 32611 6005, USA
    J Colloid Interface Sci 315:307-12. 2007
    ..Possible explanations for this disparity are discussed...
  82. ncbi Calorimetric study on interaction of water-soluble copolymers with ionic surfactant
    Hu Yan
    Department of Materials Science and Environmental Engineering, Tokyo University of Science, Yamaguchi, SanyoOnoda shi, Yamaguchi 756 0884, Japan
    J Colloid Interface Sci 315:94-8. 2007
    ..The results suggested that the EA units are the main binding sites of the copolymer with SDS...
  83. ncbi Amphiphilic azobenzenesulfonic acid anionic surfactant for water-soluble, ordered, and luminescent polypyrrole nanospheres
    M Jinish Antony
    Polymer Research Group, Chemical Sciences and Technology Division, National Institute for Interdisciplinary Science and Technology formerly Regional Research Laboratory, Thiruvananthapuram 695019, Kerala, India
    J Phys Chem B 111:12772-80. 2007
    ..The azobenzenesulfonic acid anionic surfactant is luminescent in water, and its grafting on the polypyrrole nanospheres enhances the luminescent intensity with the quantum yield in the range of 2 x 10(-3) to 3 x 10(-4)...
  84. ncbi Effect of ionic surfactants on drainage and equilibrium thickness of emulsion films
    Stoyan I Karakashev
    Division of Chemical Engineering, School of Engineering, The University of Queensland, Brisbane, Queensland 4072, Australia
    J Colloid Interface Sci 318:358-64. 2008
    ..The effect of interfacial viscosity and interfacial tension gradient (the Marangoni number) on the film drainage is also significant...
  85. ncbi Probing the relationship between interfacial concentrations and lipase activity in cationic W/O microemulsions: a quantitative study by chemical trapping
    Antara Dasgupta
    Department of Biological Chemistry and Center for Advanced Materials, Indian Association for the Cultivation of Science, Jadavpur, Kolkata 700032, India
    Langmuir 23:4137-43. 2007
    ..Moreover, the lower [Bri-] in 2-4 and 6 perhaps enhances the probability of enzyme and substrate localization at the interface, leading to higher lipase activity...
  86. ncbi The effect of oil components on the physicochemical properties and drug delivery of emulsions: tocol emulsion versus lipid emulsion
    Chi Feng Hung
    School of Medicine, Fu Jen Catholic University, Taipei, Taiwan
    Int J Pharm 335:193-202. 2007
    ..The mean vesicle size of the tocol emulsion remained unchanged during 30 days at 37 degrees C. The lipid emulsion and aqueous micelle system, respectively, showed 11- and 16-fold increases in vesicle size after 30 days of storage...
  87. ncbi Low molecular weight heparin loaded pH-sensitive microparticles
    Yvette Meissner
    InsermU734 EA3452, Faculty of Pharmacy, Nancy, France
    Int J Pharm 335:147-53. 2007
    ..These microspheres represent a promising tool for the selective oral delivery of heparin to the colon, especially interesting in the treatment of inflammatory bowel disease...
  88. ncbi The partitioning of emulsifiers in o/w emulsions: a comparative study of SANS, ultrafiltration and dialysis
    Kathleen Oehlke
    Institute of Human Nutrition and Food Science, University of Kiel, 24118 Kiel, Germany
    J Colloid Interface Sci 322:294-303. 2008
    ..In emulsions with CTAB, saturation of the interface was not achieved. The minimum headgroup area was determined by UF to be 33 A2 at a concentration of 30 mM CTAB in a 10% o/w emulsion...
  89. ncbi Ftorafur loading and controlled release from poly(ethyl-2-cyanoacrylate) and poly(butylcyanoacrylate) nanospheres
    J L Arias
    Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy, University of Granada, Spain
    Int J Pharm 337:282-90. 2007
    ....
  90. ncbi Turbidimetric measurement and prediction of dissolution rates of poorly soluble drug nanocrystals
    Matthew Todd Crisp
    Department of Chemical Engineering and Texas Materials Institute, University of Texas at Austin, Austin, TX 78712, USA
    J Control Release 117:351-9. 2007
    ..Since this resistance has received little attention in previous studies, further emphasis on the design of drug nanoparticles with more rapid interfacial reaction offers the possibility of improvements in dissolution rates...
  91. ncbi Nonlinear response of a batch BZ oscillator to the addition of the anionic surfactant sodium dodecyl sulfate
    Luciana Sciascia
    Dipartimento di Chimica Fisica F Accascina, Universita degli Studi di Palermo, Viale delle Scienze Parco d Orleans II, Pad 17, 90128 Palermo, Italy
    J Phys Chem B 111:1354-60. 2007
    ..This study has indirectly corroborated the existence of two kind of micelles and unambiguously revealed that the bromine species show a different affinity toward the spherical and rod-like micelles...
  92. ncbi Effect of ionic liquids on the aggregation behavior of PEO-PPO-PEO block copolymers in aqueous solution
    Lily Zheng
    Laboratory of Separation Science and Engineering, State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, P O Box 353, Beijing 100080, China
    J Phys Chem B 111:1327-33. 2007
    ..232 mol/L, there are P104 micelles in the aqueous solution with BmimBr embedding to the micellar core, while above this concentration, P104 micelles and BmimBr clusters coexist in the system...
  93. ncbi Effect of admicellar properties on adsolubilization: column studies and solute transport
    A Fuangswasdi
    National Research Center, Environmental Hazardous Waste Management, Chulalongkorn University, Bangkok, Thailand
    Water Res 41:1343-9. 2007
    ....
  94. ncbi Effects of anionic surfactants on ligand-promoted dissolution of iron and aluminum hydroxides
    Naraya Carrasco
    Institute of Biogeochemistry and Pollutant Dynamics, Department of Environmental Sciences, ETH Zurich, CHN, CH 8092 Zurich, Switzerland
    J Colloid Interface Sci 321:279-87. 2008
    ..However, our results show that none of these three factors can satisfactorily explain the observed effects of anionic surfactants on ligand-promoted dissolution rates of iron and aluminum hydroxides...
  95. ncbi Solubilization of an amphiphilic drug by poly(ethylene oxide)-block-poly(ester) micelles
    Sara Elhasi
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alta, Canada
    Eur J Pharm Biopharm 65:406-13. 2007
    ..In conclusion, PEO-b-PCL micelles, particularly those with longer PCL chains, were found to be efficient carriers in encapsulating amphiphilic AMI, retaining encapsulated AMI within the carrier and reducing its hemolytic activity...
  96. ncbi Micellization and synergistic interaction of binary surfactant mixtures based on sodium nonylphenol polyoxyethylene ether sulfate
    Zhong Xiu Chen
    Department of Applied Chemistry, Zhejiang Gongshang University, Hangzhou, Zhejiang 310035, People s Republic of China
    J Colloid Interface Sci 318:389-96. 2008
    ..Zeta potential and diffusion coefficient measurements of micelles confirmed the synergistic interaction between the binary surfactants...
  97. ncbi Difference in the effects of surfactants and albumin on the extent of deaggregation of purpurin 18, a model of hydrophobic photosensitizer
    Padmaja P Mishra
    Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai 400076, India
    Biophys Chem 121:224-33. 2006
    ..The formation of surfactant-induced aggregates at intermediate concentrations of the positively charged CTAB is also observed and is explained in the light of electrostatic interactions between the fluorophore and the surfactant...
  98. ncbi Solubility, chemical and photochemical stability of curcumin in surfactant solutions. Studies of curcumin and curcuminoids, XXVIII
    H Hjorth Tønnesen
    Institute of Pharmacy, University of Oslo, Norway
    Pharmazie 57:820-4. 2002
    ..The ability of curcumin to act as a photosensitizer was dependent on the type of micelles and pH of the medium...
  99. ncbi Examination of surface adsorption of sodium chloride and sodium dodecyl sulfate by surface potential measurement at the air/solution interface
    Hiromichi Nakahara
    Division of Biointerfacial Science, Graduate School of Pharmaceutical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Langmuir 21:9020-2. 2005
    ..The above variations of the surface potential cannot be elucidated by the conventional surface excess, and therefore, the new concept of surface adsorption was presented for a simple salt and a typical anionic surfactant...
  100. ncbi Determination and regulation of the migration window in electrokinetic chromatography
    Ute Pyell
    Philipps Universitat Marburg, Fachbereich Chemie, Hans Meerwein Strasse, D 35032 Marburg, Germany
    J Chromatogr A 1037:479-90. 2004
    ..Pseudostationary phases (or separation carriers) that are taken into consideration are anionic and cationic micelles, mixed micelles, microdroplets (microemulsions), polymeric pseudostationary phases and dendrimers...
  101. ncbi Surfactant tail length-dependent lipase activity profile in cationic water-in-oil microemulsions
    Antara Dasgupta
    Department of Biological Chemistry, Indian Association for the Cultivation of Science, Jadavpur, Kolkata 700032, India
    J Colloid Interface Sci 289:566-73. 2005
    ..As a notable outcome of this research, we found w/o microemulsions of 25 mM tetradecyltrimethylammonium bromide/water/isooctane/n-hexanol (z=8) producing the highest ever activity of lipase in any w/o microemulsions...

Research Grants34

  1. Functional Materials Through Bottom-Up Self-Assembly - 2007 Supramolecules & Asse
    John Texter; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  2. Postnatal Consequences of Fetal Inflammation
    Alan Jobe; Fiscal Year: 2007
    ..This research will use clinically relevant prenatal exposures and postnatal sensitization to establish under controlled conditions any link between antenatal inflammation and the hygiene hypothesis. [unreadable] [unreadable] [unreadable]..
  3. Non-Viral Vectors for Liver Gene Transfer
    Feng Liu; Fiscal Year: 2006
    ..The therapeutic effects on the metabolic disease on phenylketonuria (PKU) mice, will be examined after the PAH gene transfer using the approach in this proposal. ..
  4. Highly Elastic pH-sensitive Cationic Liposomes
    Michalakis Savva; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  5. Bile Acids, Genetic Control and Colonic Function in Irritable Bowel Syndrome
    MICHAEL L CAMILLERI; Fiscal Year: 2013
    ....
  6. INTERACTION OF TOPICAL FLUORIDE WITH HUMAN ENAMEL
    VERA CASLAVSKA; Fiscal Year: 1990
    ..Certain formulations of fluoride and surface active agents show evidence of accelerating deposition of firmly bound fluoride in enamel during enamel-fluoride ..
  7. IN-SITU INFRARED ANALYSIS OF BIOMEMBRANE MONOLAYERS
    Richard Dluhy; Fiscal Year: 1992
    ..John's Newfoundland, has agreed to collaborate on the lung surfactant studies. The results of these studies should shed new light on the physical structure of a variety of widely used biomembrane models...
  8. OCULAR SURFACE CELL CULTURE AND REPLACEMENT
    John Hassell; Fiscal Year: 1993
    ..of a number of factors, including stromal cell viability, growth factors, serum supplementation and surface active agents (e.g...
  9. Activation of clotting & cell adhesion: gas embolism
    David M Eckmann; Fiscal Year: 2010
    ..This work is the basis for neuroprotection in gas embolism-induced stroke, a persistent, growing health threat without treatment. ..
  10. CYTOMIMETIC ORGANIC CHEMISTRY
    FREDRIC MENGER; Fiscal Year: 2007
    ....
  11. ELECTRIC INJURY--IMAGING OF THERMAL/NON-THERMAL ASPECTS
    Raphael Lee; Fiscal Year: 2003
    ..abstract_text> ..
  12. Anthrax DNA vaccine for non-invasive immunization on skin
    Zhengrong Cui; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  13. Secretomes captured in vivo via ultrafiltration probes
    Chun Ming Huang; Fiscal Year: 2008
    ..We believe that using CUF probes/Mass spectrometry will be a powerful tool which can be applied to other animal models and other human diseases. [unreadable] [unreadable] [unreadable]..
  14. Acne Vaccines Targeting a Surface Sialidase and a Secreted CAMP Factor Toxin
    Chun Ming Huang; Fiscal Year: 2008
    ..The goal of this proposal is to develop systemically effective acne vaccines that can specifically suppress P. acnes-induced skin inflammation without disturbing the balance of skin flora. [unreadable] [unreadable] [unreadable]..
  15. A tri-antigen nasal anthrax vaccine against toxins and vegetative bacilli
    Zhengrong Cui; Fiscal Year: 2008
    ..The same vaccine or its modified version can also be used in agricultural industries to vaccinate cattle. [unreadable] [unreadable] [unreadable]..
  16. HORMONAL REGULATION OF LUNG DEVELOPMENT; PTHrP BIOLOGY
    John Torday; Fiscal Year: 2009
    ..These studies will provide important insights to the pathophysiology and treatment of chronic lung diseases of the newborn and adult alike. ..
  17. Neonatal Resuscitation and Preterm Lung Injury
    Alan H Jobe; Fiscal Year: 2010
    ..This translational research should result in changes in resuscitation procedures for preterm infants. ..
  18. Biopolymer Surfactants for Sealing Electroporated Membranes
    RAPHAEL CARL LEE; Fiscal Year: 2010
    ..Finally, we will conduct studies in parallel to determine if surfactant rescued cells manifest normal phenotype during proliferation or exhibit effects of mutations caused by unrepaired DMA. ..
  19. Immunological Secretomes of the Early Anthrax Infection
    Chun Ming Huang; Fiscal Year: 2010
    ..This protein will thus serve as a positive control to evaluate novel antigens identified in the proposed studies. ..
  20. Comparative In Vivo Biodistribution of Characterized Manufactured Nanomaterials
    Nancy A Monteiro Riviere; Fiscal Year: 2010
    ..These coordinated studies will provide data to link physical chemical characterizations to in vivo MNM disposition. ..
  21. LUNG PHOSPHOLIPID APPEARANCE AND STABILITY
    Alan Jobe; Fiscal Year: 2002
    ....
  22. NEW MEDIATORS OF CLINICAL LUNG MATURATION
    Alan Jobe; Fiscal Year: 2007
    ..A goal is to identify a mediator with potential for clinical use to induce lung maturation. ..
  23. S. aureus SarU and Rot regulate virulence factor genes
    Peter McNamara; Fiscal Year: 2004
    ..Aim 2. To characterize mechanism(s) of SarU activation of a-toxin production by demonstrating direct and temporally appropriate interactions between SarU and its target genes. ..
  24. Biomimetic Coatings for Small Diameter Vascular Grafts
    Shuwu Wang; Fiscal Year: 2004
    ..We anticipate that this project will lead to highly effective biomimetic materials that facilitate shear stable modification of small diameter vascular prostheses that demonstrate improved blood compatibility. ..
  25. NEONATAL TRAINING GRANT
    Alan Jobe; Fiscal Year: 2005
    ..The goal for this training grant is to support only research training for Neonatologists who have the potential and motivation to become successful research oriented academic neonatologists. ..
  26. CARDIOTOXICITY OF STREPTOCOCCAL PYROGENIC EXOTOXINS
    Patrick Schlievert; Fiscal Year: 2006
    ....
  27. Dystrophic Cardiomyopathies in mdx
    DeWayne Townsend; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  28. Platelet Liposomal Drug Delivery--Thrombosis /Restenosis
    Shuwu Wang; Fiscal Year: 2006
    ..The targeted liposomal system proposed could reduce the costs in both treatment areas with a 5% reduction in revascularizations alone leading to >$60 million annual medical cost savings. ..
  29. Anthrax vaccination by targeting spore germination
    Chun Ming Huang; Fiscal Year: 2005
    ..This unprecedented study will elicit the pathological mechanisms and vaccination capabilities of immune inhibitor A and camelysin expressed in Bacillus anthracis. ..
  30. Polymer-Surfactant Therapy in Rat Models of ARDS
    HWILLIAM TAEUSCH; Fiscal Year: 2010
    ..Overall this project will not only develop a promising new therapy of ALI/ARDS, but will also foster basic understanding of mechanisms of surfactant inhibition and ways to overcome it. ..
  31. Quantitating Absorption of Complex Chemical Mixtures
    Jim Riviere; Fiscal Year: 2009
    ..abstract_text> ..
  32. Contrast-Enhanced Ultrasound Detection of Angiogenesis
    Flemming Forsberg; Fiscal Year: 2004
    ..If successful, this project will permit non-invasive ultrasound evaluations of anti-angiogenic tumor therapies in animals as well as humans. ..
  33. Subharmonic Microbubble Signals for Pressure Estimation
    Flemming Forsberg; Fiscal Year: 2008
    ..This will allow potentially life-threatening diseases, such as increased pressure in the liver, to be diagnosed early. [unreadable] [unreadable] [unreadable]..