Summary: Liquids that dissolve other substances (solutes), generally solids, without any change in chemical composition, as, water containing sugar. (Grant & Hackh's Chemical Dictionary, 5th ed)

Top Publications

  1. ncbi Exploring protein native states and large-scale conformational changes with a modified generalized born model
    Alexey Onufriev
    Department of Computer Science, Virginia Tech, Blacksburg, Virginia, USA
    Proteins 55:383-94. 2004
  2. ncbi Improving enzymes by using them in organic solvents
    A M Klibanov
    Department of Chemistry, Massachusetts Institute of Technology, Cambridge 02139, USA
    Nature 409:241-6. 2001
  3. pmc Grid inhomogeneous solvation theory: hydration structure and thermodynamics of the miniature receptor cucurbit[7]uril
    Crystal N Nguyen
    Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093 0736, USA
    J Chem Phys 137:044101. 2012
  4. ncbi Human telomere sequence DNA in water-free and high-viscosity solvents: G-quadruplex folding governed by Kramers rate theory
    Ford M Lannan
    School of Chemistry and Biochemistry, Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia 30332, USA
    J Am Chem Soc 134:15324-30. 2012
  5. ncbi Bacteria tolerant to organic solvents
    S Isken
    Department of Food Technology and Nutritional Sciences, Wageningen Agricultural University, The Netherlands
    Extremophiles 2:229-38. 1998
  6. ncbi Structural determinants of protein evolution are context-sensitive at the residue level
    Eric A Franzosa
    Boston University, Boston, USA
    Mol Biol Evol 26:2387-95. 2009
  7. pmc Assessing the impact of secondary structure and solvent accessibility on protein evolution
    N Goldman
    Department of Genetics, University of Cambridge, Cambridge CB2 3EH, United Kingdom
    Genetics 149:445-58. 1998
  8. ncbi A point-charge force field for molecular mechanics simulations of proteins based on condensed-phase quantum mechanical calculations
    Yong Duan
    Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, USA
    J Comput Chem 24:1999-2012. 2003
  9. pmc SCRATCH: a protein structure and structural feature prediction server
    J Cheng
    Institute for Genomics and Bioinformatics, University of California Irvine, CA, USA
    Nucleic Acids Res 33:W72-6. 2005
  10. pmc Maternal occupational exposure to organic solvents during early pregnancy and risks of neural tube defects and orofacial clefts
    Tania A Desrosiers
    Department of Epidemiology, Campus Box 7435, University of North Carolina, Chapel Hill, NC 27599, USA
    Occup Environ Med 69:493-9. 2012

Detail Information

Publications394 found, 100 shown here

  1. ncbi Exploring protein native states and large-scale conformational changes with a modified generalized born model
    Alexey Onufriev
    Department of Computer Science, Virginia Tech, Blacksburg, Virginia, USA
    Proteins 55:383-94. 2004
    ..5 A after 6 ns of simulation time. The structure of Barnase/Barstar complex is regenerated, starting from an unbound state, to within 1.9 A relative to the crystal structure of the complex...
  2. ncbi Improving enzymes by using them in organic solvents
    A M Klibanov
    Department of Chemistry, Massachusetts Institute of Technology, Cambridge 02139, USA
    Nature 409:241-6. 2001
    The technological utility of enzymes can be enhanced greatly by using them in organic solvents rather than their natural aqueous reaction media...
  3. pmc Grid inhomogeneous solvation theory: hydration structure and thermodynamics of the miniature receptor cucurbit[7]uril
    Crystal N Nguyen
    Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093 0736, USA
    J Chem Phys 137:044101. 2012
    ..Thus, localized regions of high solvent density can be generated in a binding site without strong, attractive solute-solvent interactions...
  4. ncbi Human telomere sequence DNA in water-free and high-viscosity solvents: G-quadruplex folding governed by Kramers rate theory
    Ford M Lannan
    School of Chemistry and Biochemistry, Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia 30332, USA
    J Am Chem Soc 134:15324-30. 2012
    ..due to HTS DNA becoming kinetically trapped in a folded state that is apparently not accessed in lower viscosity solvents. A comparison of times required for the G-quadruplex to convert from its aqueous-preferred folded state to its ..
  5. ncbi Bacteria tolerant to organic solvents
    S Isken
    Department of Food Technology and Nutritional Sciences, Wageningen Agricultural University, The Netherlands
    Extremophiles 2:229-38. 1998
    The toxic effects that organic solvents have on whole cells is an important drawback in the application of these solvents in environmental biotechnology and in the production of fine chemicals by whole-cell biotransformations...
  6. ncbi Structural determinants of protein evolution are context-sensitive at the residue level
    Eric A Franzosa
    Boston University, Boston, USA
    Mol Biol Evol 26:2387-95. 2009
    ..These discoveries serve to elucidate and unite structure-evolution relationships at the residue and whole-protein levels...
  7. pmc Assessing the impact of secondary structure and solvent accessibility on protein evolution
    N Goldman
    Department of Genetics, University of Cambridge, Cambridge CB2 3EH, United Kingdom
    Genetics 149:445-58. 1998
  8. ncbi A point-charge force field for molecular mechanics simulations of proteins based on condensed-phase quantum mechanical calculations
    Yong Duan
    Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, USA
    J Comput Chem 24:1999-2012. 2003
    ..charge sets, as judged by overall agreement between dipole moments, allows a smooth transition to the new force field in the area of ligand-binding calculations. Test simulations on a large set of proteins are also discussed...
  9. pmc SCRATCH: a protein structure and structural feature prediction server
    J Cheng
    Institute for Genomics and Bioinformatics, University of California Irvine, CA, USA
    Nucleic Acids Res 33:W72-6. 2005
    ..The user simply provides an amino acid sequence and selects the desired predictions, then submits to the server. Results are emailed to the user. The server is available at
  10. pmc Maternal occupational exposure to organic solvents during early pregnancy and risks of neural tube defects and orofacial clefts
    Tania A Desrosiers
    Department of Epidemiology, Campus Box 7435, University of North Carolina, Chapel Hill, NC 27599, USA
    Occup Environ Med 69:493-9. 2012
    Though toxicological experiments demonstrate the teratogenicity of organic solvents in animal models, epidemiologic studies have reported inconsistent results...
  11. ncbi Purification and characterization of a thermostable keratinolytic serine alkaline proteinase from Streptomyces sp. strain AB1 with high stability in organic solvents
    Bassem Jaouadi
    Laboratoire d Enzymes et de Metabolites des Procaryotes LEMP, Centre de biotechnologie de Sfax CBS, B P 1177, Route de Sidi Mansour Km 6, 3018 Sfax, Tunisia
    Bioresour Technol 101:8361-9. 2010
    ..KERAB exhibited stability to detergents and high resistance against organic solvents and was able to degrade feathers completely...
  12. ncbi Color vision: a sensitive indicator of exposure to neurotoxins
    F Gobba
    Dipartimento di Scienze Igienistiche, Microbiologiche e Biostatistiche, Universita di Modena e Reggio Emilia, Modena, Italy
    Neurotoxicology 21:857-62. 2000
    ..D-15 d, or other color perception tests, impairment in color vision was observed among workers exposed to several solvents (styrene, perchloroethylene, toluene, n-hexane, and carbon disulfide), or to solvent mixtures, and also to metals ..
  13. pmc Prediction of solvent accessibility and sites of deleterious mutations from protein sequence
    Huiling Chen
    Department of Physics, Drexel University Philadelphia, PA 19104, USA
    Nucleic Acids Res 33:3193-9. 2005
    ..Of the total of 130 residues predicted as sites of deleterious mutations, 104 (or 80%) were correct...
  14. pmc The relationship between relative solvent accessibility and evolutionary rate in protein evolution
    Duncan C Ramsey
    Center for Computational Biology and Bioinformatics, Institute for Cellular and Molecular Biology, University of Texas, Austin, Texas 78712, USA
    Genetics 188:479-88. 2011
    ..Because of this link, any future insight into the biophysical mechanisms that determine amino acid distributions will improve our understanding of evolutionary rates...
  15. ncbi Computing the thermodynamic contributions of interfacial water
    Zheng Li
    Department of Chemistry, City College of New York, New York, NY, USA
    Methods Mol Biol 819:393-404. 2012
    ..This chapter gives an overview of the theory and its applications and describes how to calculate the thermodynamic contributions of ordered water molecules using STOW...
  16. ncbi Effect of various chemicals as solvents on the dissolution of set white mineral trioxide aggregate: an in vitro study
    Suresh Nandini
    Department of Conservative Dentistry and Endodontics, Meenakshi Ammal Dental College, Maduravoyal, Chennai, Tamil Nadu, India
    J Endod 36:135-8. 2010
    ..Because MTA is alkaline in nature, it might interact with acids or chemicals and could disintegrate. The aim of this study was to assess the effect of various chemicals on dissolution of white MTA (WMTA)...
  17. ncbi Dissociation and degradation of thiol-modified DNA on gold nanoparticles in aqueous and organic solvents
    Nishi Bhatt
    Department of Chemistry, Waterloo Institute for Nanotechnology, University of Waterloo, 200 University Avenue West, Waterloo, Ontario, N2L 3G1, Canada
    Langmuir 27:6132-7. 2011
    ..Most organic solvents showed a moderate protection effect on the gold-thiol bond...
  18. ncbi Conformational behavior and aggregation of alpha-synuclein in organic solvents: modeling the effects of membranes
    Larissa A Munishkina
    Department of Chemistry and Biochemistry, University of California, Santa Cruz, California 95064, USA
    Biochemistry 42:2720-30. 2003
    ..All solvents that were studied induced folding of alpha-synuclein, with the common first stage being formation of a partially ..
  19. ncbi Solvent-tolerant bacteria for biotransformations in two-phase fermentation systems
    Hermann J Heipieper
    Department of Bioremediation, UFZ Helmholtz Centre for Environmental Research, Permoserstr 15, 04318 Leipzig, Germany
    Appl Microbiol Biotechnol 74:961-73. 2007
    ..As a matter of course, adequate organic solvents have to possess hydrophobicity properties akin to substrates and products of interest, which in turn involves ..
  20. ncbi A comprehensive untargeted metabonomic analysis of human steatotic liver tissue by RP and HILIC chromatography coupled to mass spectrometry reveals important metabolic alterations
    Juan C García-Cañaveras
    Unidad de Hepatologia Experimental, Instituto de Investigación Sanitaria Fundación Hospital La Fe, Valencia, Spain
    J Proteome Res 10:4825-34. 2011
  21. ncbi Ethanol extract of Adiantum capillus-veneris L. suppresses the production of inflammatory mediators by inhibiting NF-κB activation
    Qianying Yuan
    Key Laboratory of Natural Medicinal Chemistry and Resources Evaluation of Hubei Province, School of Pharmacy, Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430030, China
    J Ethnopharmacol 147:603-11. 2013
    ..Adiantum capillus-veneris L. is a wildly distributed plant species and has been extensively used in south of China as traditional folk medicine for the treatment of inflammatory diseases...
  22. ncbi Application of inhomogeneous fluid solvation theory to model the distribution and thermodynamics of water molecules around biomolecules
    David J Huggins
    University of Cambridge, Hutchison MRC Research Centre, Hills Road, Cambridge, CB2 0XZ, UK
    Phys Chem Chem Phys 14:15106-17. 2012
    ..This study provides important information on how inhomogeneous fluid solvation theory can be employed to understand the structures and intermolecular interactions of biomolecules...
  23. ncbi Exposure during pregnancy to glycol ethers and chlorinated solvents and the risk of congenital malformations
    Sylvaine Cordier
    IRSET Inserm U1085 Univ Rennes I IFR 140, Rennes, France sylvaine
    Epidemiology 23:806-12. 2012
    Exposure to solvents during pregnancy has long been suspected of increasing the risk of congenital malformations, but the lack of prospective assessment of specific solvent exposures has prevented definitive conclusions.
  24. ncbi Consistent sets of spectrophotometric chlorophyll equations for acetone, methanol and ethanol solvents
    Raymond J Ritchie
    School of Biological Sciences, The University of Sydney, Sydney, NSW 2006, Australia
    Photosynth Res 89:27-41. 2006
    ..its primary photosynthetic pigment and also has Chl a, have been developed for 90% acetone, methanol and ethanol solvents. These equations for different solvents give chlorophyll assays that are consistent with each other...
  25. ncbi Gender differences in risk of renal cell carcinoma and occupational exposures to chlorinated aliphatic hydrocarbons
    M Dosemeci
    Occupational Epidemiology Branch, National Cancer Institute, Bethesda, Maryland, USA
    Am J Ind Med 36:54-9. 1999
    Organic solvents have been associated with renal cell cancer; however, the risk by gender and type of solvents is nuclear.
  26. pmc Northern, morphological, and fermentation analysis of spo0A inactivation and overexpression in Clostridium acetobutylicum ATCC 824
    Latonia M Harris
    Department of Chemical Engineering, Northwestern University, Evanston, Illinois 60208, USA
    J Bacteriol 184:3586-97. 2002
  27. pmc Application of supercritical antisolvent method in drug encapsulation: a review
    Mahshid Kalani
    Chemical and Environmental Engineering, Faculty of Engineering, University Putra Malaysia, Selangor Darul Ehsan, Malaysia
    Int J Nanomedicine 6:1429-42. 2011
    ..various conditions in the process, such as pressure, temperature, concentration, chemical compositions (organic solvents, drug, and biodegradable polymer), nozzle geometry, CO(2) flow rate, and the liquid phase flow rate on particle ..
  28. pmc PDB2PQR: an automated pipeline for the setup of Poisson-Boltzmann electrostatics calculations
    Todd J Dolinsky
    Department of Biochemistry and Molecular Biophysics, Center for Computational Biology, Washington University in St Louis, 700 S Euclid Avenue, Campus Box 8036, St Louis, MO 63110, USA
    Nucleic Acids Res 32:W665-7. 2004
  29. ncbi Binding site detection and druggability index from first principles
    Jesus Seco
    Institucio Catalana de Recerca i Estudis Avancats ICREA, Institut de Biomedicina de la Universitat de Barcelona IBUB, Barcelona, Spain
    J Med Chem 52:2363-71. 2009
    ..Both X-ray crystallography and NMR experiments have demonstrated that organic solvents bind precisely at these locations...
  30. pmc In vivo and in vitro evidence that TtgV is the specific regulator of the TtgGHI multidrug and solvent efflux pump of Pseudomonas putida
    Antonia Rojas
    Department of Plant Biochemistry and Molecular and Cellular Biology, Consejo Superior de Investigaciones Cientificas, Estacion Experimental del Zaidin, E 18008 Granada, Spain
    J Bacteriol 185:4755-63. 2003
    ..The ttgGHI operon is expressed constitutively from two overlapping promoters in the absence of solvents and at a higher level in their presence, but not in response to antibiotics...
  31. ncbi Preparation, characterization and physico-chemical properties of solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC): their benefits as colloidal drug carrier systems
    M Uner
    Istanbul University, Faculty of Pharmacy, Department of Pharmaceutical Technology, Istanbul, Turkey
    Pharmazie 61:375-86. 2006
  32. ncbi Grand canonical Monte Carlo simulations of water in protein environments
    Hyung June Woo
    Department of Biochemistry, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Chem Phys 121:6392-400. 2004
    ..Im, S. Berneche, and B. Roux, J. Chem. Phys. 114, 2924 (2001)]. As a last illustration of water confined in the interior of a protein, the hydration of the central cavity of the KcsA potassium channel is simulated...
  33. ncbi Single particle characterization of iron-induced pore-forming alpha-synuclein oligomers
    Marcus Kostka
    CNS Research, Boehringer Ingelheim Pharma GmbH and Co KG, CNS Research, Birkendorferstrasse 65, 88397 Biberach, Germany
    J Biol Chem 283:10992-1003. 2008
    ..Organic solvents were used to trigger aggregation, which resulted in small oligomers ("intermediate I")...
  34. ncbi Thermal stability of alpha-amylase in aqueous cosolvent systems
    Jay Kant Yadav
    Department of Protein Chemistry and Technology, Central Food Technological Research Institute, Mysore 570020, India
    J Biosci 34:377-87. 2009
    ..Preferential interaction parameters indicated extensive hydration of the enzyme in the presence of cosolvents...
  35. ncbi Estimation of inter-residue distances in spin labeled proteins at physiological temperatures: experimental strategies and practical limitations
    C Altenbach
    Jules Stein Eye Institute and Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095-7008, USA
    Biochemistry 40:15471-82. 2001
    ..The existence of such distance distributions places important constraints on the interpretation of internitroxide distances in terms of protein structure and structural changes...
  36. ncbi A comparative study on phenolic profiles and antioxidant activities of legumes as affected by extraction solvents
    B J Xu
    Dept of Cereal and Food Sciences, North Dakota State Univ, Fargo, ND 58105, USA
    J Food Sci 72:S159-66. 2007
    ..These results indicated that solvents with different polarity had significant effects on total phenolic contents, extracted components, and antioxidant ..
  37. ncbi Predicting small-molecule solvation free energies: an informal blind test for computational chemistry
    Anthony Nicholls
    OpenEye Scientific Software, Inc, Santa Fe, New Mexico 87508, USA
    J Med Chem 51:769-79. 2008
    ..6 kcal/mol, with the explicit solvent free energy approach yielding somewhat greater accuracy but at greater computational expense. Insights from outliers and suggestions for future prospective challenges of this kind are presented...
  38. ncbi Islet amyloid polypeptide: identification of long-range contacts and local order on the fibrillogenesis pathway
    S B Padrick
    Department of Molecular Biophysics and Biochemistry, Yale University, 266 Whitney Avenue, New Haven, CT 06520, USA
    J Mol Biol 308:783-94. 2001
    ..Parallel assessment of fiber formation using the histological dye, ThT, indicate that ordering at the C terminus of islet amyloid polypeptide is coincident with, and thus indicative of, fiber formation...
  39. ncbi Hydrophobicity: is LogP(o/w) more than the sum of its parts?
    G Eugene Kellogg
    Institute for Structural Biology and Drug Discovery and Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, Richmond, VA 23298 0133, USA
    Eur J Med Chem 35:651-61. 2000
    ..Several recent applications of HINT in structure-based and ligand-based drug discovery are reviewed. Finally, future directions in the HINT model development are proposed...
  40. ncbi Conformational selection or induced fit for Brinker and DNA recognition
    Fang Qin
    College of Life Sciences and Biotechnology, Shanghai Jiaotong University, 800 Dongchuan Road, Shanghai, 200240, China
    Phys Chem Chem Phys 13:1407-12. 2011
    ..These methods can be used for the research of other biomolecular folding upon ligand-binding...
  41. pmc Force field influences in beta-hairpin folding simulations
    Thu Zar Lwin
    Department of Molecular Biology and Biochemistry, University of California, Irvine, California 92697, USA
    Protein Sci 15:2642-55. 2006
    ..However, detailed folding pathways, such as the order of backbone hydrogen bond zipping and the existence of intermediate states, are different between the two force fields, leading to force field-dependent folding mechanisms...
  42. ncbi Bond strength of Epiphany sealer prepared with resinous solvent
    Fuad Jacob Abi Rached-Junior
    School of Dentistry, University of Ribeirao Preto, Sao Paulo, Brazil
    J Endod 35:251-5. 2009
    ..01). The resinous solvent of Epiphany system increased the bond strength of Epiphany sealer to dentin walls when followed by photoactivation...
  43. ncbi Analysis of catalytic residues in enzyme active sites
    Gail J Bartlett
    Department of Biochemistry and Molecular Biology, University College London, Darwin Building, Gower Street, London WC1E 6BT, UK
    J Mol Biol 324:105-21. 2002
    ..It is hoped that this information will provide a better understanding of the molecular mechanisms involved in catalysis and a heuristic basis for predicting catalytic residues in enzymes of unknown function...
  44. pmc Constant pH molecular dynamics with proton tautomerism
    Jana Khandogin
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, California, USA
    Biophys J 89:141-57. 2005
    ..Based on the simulations of OMTKY3 and RNase A, the current work has demonstrated the capability of the CPHMD technique in revealing pH-coupled conformational dynamics of protein side chains...
  45. ncbi The psychological effects of exposure to mixed organic solvents on car painters
    I Böckelmann
    Institute of Occupational Medicine and Hygiene, Otto von Guericke University of Magdeburg, Germany
    Disabil Rehabil 24:455-61. 2002
    Interest in diseases of the nervous system resulting from occupational exposure to mixed organic solvents has greatly increased...
  46. ncbi Partial specific volume and solvent interactions of amphipol A8-35
    Yann Gohon
    Laboratoire de Physico Chimie Moléculaire des Membranes Biologiques, UMR 7099, CNRS and Universite Paris 7, Institut de Biologie Physico Chimique, CNRS FRC 550, 13 rue Pierre et Marie Curie, F 75005 Paris, France
    Anal Biochem 334:318-34. 2004
  47. pmc Analysis of the impact of solvent on contacts prediction in proteins
    Sergey A Samsonov
    Structural Bioinformatics, BIOTEC TU Dresden, Tatzberg, Germany
    BMC Struct Biol 9:22. 2009
    ..We have observed that current "dry" correlated mutations approaches might not properly predict certain interactions in protein interfaces due to the fact that they are water-mediated...
  48. ncbi Charged gold nanoparticles in non-polar solvents: 10-min synthesis and 2D self-assembly
    Matthew N Martin
    Department of Physics, Applied Physics, and Astronomy, Rensselaer Polytechnic Institute, Troy, New York 12180, USA
    Langmuir 26:7410-7. 2010
    ..reproducible chemical synthesis method for colloidal gold nanoparticles which are negatively charged in nonpolar solvents and coated with hydrophobic organic molecules...
  49. pmc Atom depth as a descriptor of the protein interior
    Alessandro Pintar
    Protein Structure and Bioinformatics Group, International Centre for Genetic Engineering and Biotechnology, Area Science Park, Padriciano 99, 34012 Trieste, Italy
    Biophys J 84:2553-61. 2003
    ..Finally, we find a correlation between highly conserved residues in structural neighbors of the same fold type, and their mean residue depth in the reference structure...
  50. pmc Involvement of outer membrane protein TolC, a possible member of the mar-sox regulon, in maintenance and improvement of organic solvent tolerance of Escherichia coli K-12
    R Aono
    Department of Bioengineering, Faculty of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama, Japan
    J Bacteriol 180:938-44. 1998
    ..The tolerance level was restored by transformation of the transductants with a wild-type tolC gene. Therefore, it is evident that TolC is essential for E. coli to maintain organic solvent tolerance...
  51. ncbi From transition paths to transition states and rate coefficients
    Gerhard Hummer
    Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Building 5, Bethesda, Maryland 20892 0520, USA
    J Chem Phys 120:516-23. 2004
    ..An algorithm is proposed to calculate rate coefficients from the transition-path and equilibrium ensembles by estimating the frequency of transitions between reactants and products...
  52. ncbi Occupational exposure to solvents and risk of lymphoma subtypes: results from the Epilymph case-control study
    P Cocco
    Department of Public Health, Occupational Health Section, University of Cagliari, Asse Didattico Policlinico Universitario, SS 554, Km 4, 500, 09042 Monserrato Cagliari, Italy
    Occup Environ Med 67:341-7. 2010
    Several studies have suggested an association between occupational exposure to solvents and lymphoma risk. However, findings are inconsistent and the role of specific chemicals is not known...
  53. pmc A unified model of protein dynamics
    Hans Frauenfelder
    Los Alamos National Laboratory, Los Alamos, NM 87545, USA
    Proc Natl Acad Sci U S A 106:5129-34. 2009
  54. ncbi Visual dysfunction in workers exposed to a mixture of organic solvents
    Yingyan Gong
    Department of Public Health, Hokkaido University Graduate School of Medicine, North 15, West 7, Sapporo 060 8638, Japan
    Neurotoxicology 24:703-10. 2003
    ..this study was to investigate the relationship between the workers occupationally exposed to a mixture of organic solvents and their visual functions...
  55. ncbi Crystal structure of human ornithine decarboxylase at 2.1 A resolution: structural insights to antizyme binding
    J J Almrud
    Department of Chemistry, The University of Texas at Austin, Austin, TX, 78712, USA
    J Mol Biol 295:7-16. 2000
  56. doi CHARMM-GUI: a web-based graphical user interface for CHARMM
    Sunhwan Jo
    J Comput Chem 29:1859-65. 2008
    ..Future directions of the CHARMM-GUI development project are also discussed briefly together with other features in the CHARMM-GUI website, such as Archive and Movie Gallery...
  57. ncbi Modular representations of odorants in the glomerular layer of the rat olfactory bulb and the effects of stimulus concentration
    B A Johnson
    Department of Neurobiology and Behavior, University of California, Irvine, California 92697 4550, USA
    J Comp Neurol 422:496-509. 2000
  58. pmc Determination of alkali and halide monovalent ion parameters for use in explicitly solvated biomolecular simulations
    In Suk Joung
    Department of Bioengineering, College of Engineering, University of Utah, 2000 South 30 East, Skaggs Hall 201, Salt Lake City, UT 84112, USA
    J Phys Chem B 112:9020-41. 2008
    ..In addition to well reproducing the solution and crystal properties, the new ion parameters well reproduce binding energies of the ions to water and the radii of the first hydration shells...
  59. ncbi Design and production of nanoparticles formulated from nano-emulsion templates-a review
    Nicolas Anton
    Inserm U646, Ingenierie de la Vectorisation Particulaire, 10 rue A Boquel, F 49100 Angers, France
    J Control Release 128:185-99. 2008
    ..differences may include drug sensitivity to temperature, high-shear devices, or even contact with organic solvents. Likewise, nano-emulsion formulation processes must be chosen in function of the selected therapeutic goals of ..
  60. pmc Impact of the solvent capacity constraint on E. coli metabolism
    Alexei Vazquez
    The Simons Center for Systems Biology, Institute for Advanced Study, Princeton, NJ 08540, USA
    BMC Syst Biol 2:7. 2008
    ..Molecular crowding in a cell's cytoplasm is one such potential constraint, as it limits the solvent capacity available to metabolic enzymes...
  61. ncbi Peripheral and central auditory dysfunction induced by occupational exposure to organic solvents
    Adrian Fuente
    School of Speech and Hearing Sciences, Medical Faculty, Universidad de Chile, Santiago, Chile
    J Occup Environ Med 51:1202-11. 2009
    ..To examine the effects of solvent exposure on hearing function, through an audiological test battery, in a population not occupationally exposed to high levels of noise...
  62. ncbi Proteins in organic solvents
    C Mattos
    Department of Molecular and Structural Biochemistry, North Carolina State University, 128 Polk Hall, Raleigh, NC 27695 7622, USA
    Curr Opin Struct Biol 11:761-4. 2001
    Catalysis in organic solvents and the mapping of protein surfaces using multiple solvent crystal structures are two rapidly developing areas of research...
  63. ncbi Effects of coexposure to noise and mixture of organic solvents on hearing in dockyard workers
    Mariola Sliwinska-Kowalska
    Department of Physical Hazards, Nofer Institute of Occupational Medicine, Lodz, Poland
    J Occup Environ Med 46:30-8. 2004
    ..mixture-exposed and 184 noise-only-exposed) were referred to 205 control subjects not exposed to either noise or solvents. The odds ratio (OR) of hearing loss was significantly increased by approximately 3 times in the noise-only group ..
  64. pmc A role for solvents in the toxicity of agricultural organophosphorus pesticides
    Michael Eddleston
    Clinical Pharmacology Unit, University BHF Centre for Cardiovascular Science, University of Edinburgh, UK
    Toxicology 294:94-103. 2012
    ..doses of agricultural emulsifiable concentrate (EC) dimethoate, dimethoate active ingredient (AI) alone, or solvents. Cardiorespiratory physiology and neuromuscular (NMJ) function, blood AChE activity, and arterial lactate ..
  65. pmc Molecular cloning of a novel bioH gene from an environmental metagenome encoding a carboxylesterase with exceptional tolerance to organic solvents
    Yuping Shi
    Key Laboratory of Quality and Safety Risk Assessment for Aquatic Products on Storage and Preservation Shanghai, China Ministry of Agriculture, Engineering Centre for Quality Control and Risk Assessment of Aquatic Products, College of Food Science and Technology, Shanghai Ocean University, 999 Hu Cheng Huan Road, 201306, Shanghai, PR China
    BMC Biotechnol 13:13. 2013
    ..The biochemical property of the purified BioHx protein was also investigated...
  66. ncbi Efficient extraction of canthaxanthin from Escherichia coli by a 2-step process with organic solvents
    Mark A Scaife
    Fermentation and Metabolic Engineering Group, Ocean Nutrition Canada Ltd, 101 Research Drive, Dartmouth, Nova Scotia, Canada
    Bioresour Technol 111:276-81. 2012
    ..and ethyl acetate was carried out with each solvent separately, and subsequently the most efficient solvents were tested in combination, both as mixtures and sequentially...
  67. ncbi A tale of two tails: why are terminal residues of proteins exposed?
    Etai Jacob
    The Mina and Everard Goodman Faculty of Life Sciences, bar Ilan University Ramat Gan, 52900, Israel
    Bioinformatics 23:e225-30. 2007
    ..Progressively, each selection raises the proportion of proteins with termini on the surface, resulting in similar proportions to those observed for real proteins...
  68. ncbi Association between maternal occupational exposure to organic solvents and congenital heart defects, National Birth Defects Prevention Study, 1997-2002
    Suzanne M Gilboa
    National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Occup Environ Med 69:628-35. 2012
    ..between congenital heart defects (CHDs) in offspring and estimated maternal occupational exposure to chlorinated solvents, aromatic solvents and Stoddard solvent during the period from 1 month before conception through the first ..
  69. ncbi Organic solvents and the risk of multiple sclerosis
    Trond Riise
    Section for Occupational Medicine, Department of Public Health, University of Bergen, Norway
    Epidemiology 13:718-20. 2002
    Epidemiologic studies suggest that environmental factors may be part of the yet unknown causation of multiple sclerosis (MS). Several case-control studies have shown a history of elevated exposure to organic solvents among cases.
  70. ncbi The Upper Midwest Health Study: gliomas and occupational exposure to chlorinated solvents
    Avima M Ruder
    National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, OH, USA
    Occup Environ Med 70:73-80. 2013
    Occupational exposure to chlorinated aliphatic solvents has been associated with an increased cancer risk, including brain cancer. However, many of these solvents remain in active, large-volume use...
  71. pmc Organic solvents as risk factor for autoimmune diseases: a systematic review and meta-analysis
    Carolina Barragán-Martínez
    Center for Autoimmune Diseases Research CREA, School of Medicine and Health Sciences, Universidad del Rosario, Bogota, Colombia
    PLoS ONE 7:e51506. 2012
    ..Among the environmental factors are organic solvents (OSs), which are chemical compounds used routinely in commercial industries...
  72. ncbi A thermostable variant of fructose bisphosphate aldolase constructed by directed evolution also shows increased stability in organic solvents
    Jijun Hao
    School of Biochemistry and Microbiology and the Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, UK
    Protein Eng Des Sel 17:689-97. 2004
    ..In addition, variant 4-43D6 shows increased stability to treatment with organic solvents. DNA sequencing of the evolved variants has identified the mutations which have been introduced and which lead to ..
  73. ncbi Risk of selected cancers due to occupational exposure to chlorinated solvents in a case-control study in Montreal
    Krista Yorita Christensen
    University of Montreal Hospital Research Center, Montreal, Quebec, Canada
    J Occup Environ Med 55:198-208. 2013
    To evaluate the association between exposure to chlorinated solvents and cancer.
  74. ncbi Risk of childhood leukaemia and non-Hodgkin's lymphoma after parental occupational exposure to solvents and other agents: the SETIL Study
    Lucia Miligi
    Occupational and Environmental Epidemiology Unit, ISPO Cancer Prevention and Research Institute, Florence, Italy
    Occup Environ Med 70:648-55. 2013
    ..In the context of the Italian Multicentric Epidemiological Study on Risk Factors for Childhood Leukaemia and Non-Hodgkin's Lymphoma (SETIL), the risk of childhood cancer was investigated in relation to parental occupational exposures...
  75. pmc Bound water at protein-protein interfaces: partners, roles and hydrophobic bubbles as a conserved motif
    Mostafa H Ahmed
    Department of Medicinal Chemistry, Virginia Commonwealth University, Richmond, Virginia, United States of America
    PLoS ONE 6:e24712. 2011
    ..One feature of these complexes that has received little attention is the role of water molecules in the interfacial region...
  76. pmc A one-step, solvothermal reduction method for producing reduced graphene oxide dispersions in organic solvents
    Sergey Dubin
    Department of Chemistry and Biochemistry and California NanoSystems Institute, University of California, Los Angeles, California 90095, USA
    ACS Nano 4:3845-52. 2010
    ..SRGO sheets are redispersible in a variety of organic solvents, which may hold promise as an acceptor material for bulk heterojunction photovoltaic cells, or electromagnetic ..
  77. ncbi Ultrasound-induced switching of sheetlike coordination polymer microparticles to nanofibers capable of gelating solvents
    Shiyong Zhang
    Key Laboratory of Green Chemistry and Technology of Ministry of Education, College of Chemistry, and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610064, People s Republic of China
    J Am Chem Soc 131:1689-91. 2009
    ..on a readily available coordination polymer {Zn(bibp)(2)(OSO(2)CF(3))(2)}(n), in which ultrasound changes the morphology of the material from sheetlike microparticles into nanofibers, resulting in the immobilization of organic solvents.
  78. pmc Structure and dynamics of amyloid-β segmental polymorphisms
    Workalemahu M Berhanu
    Department of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma, United States of America
    PLoS ONE 7:e41479. 2012
  79. pmc Occupational and environmental exposures and risk of systemic lupus erythematosus: silica, sunlight, solvents
    Glinda S Cooper
    Department of Environmental and Occupational Health, The George Washington University, School of Public Health and Health Services, Washington, DC, USA
    Rheumatology (Oxford) 49:2172-80. 2010
    ..We examined occupational and non-occupational exposures in relation to risk of SLE in a case-control study conducted through the Canadian Network for Improved Outcomes in SLE (CaNIOS)...
  80. ncbi Enzyme catalysis in organic solvents: influence of water content, solvent composition and temperature on Candida rugosa lipase catalyzed transesterification
    Daniela Herbst
    Helmut Schmidt University University of Federal Armed Forces Hamburg, Process Engineering, D 22043 Hamburg, Germany
    J Biotechnol 162:398-403. 2012
    ..Taken together, the decrease in conversion and the increase in selectivity with increasing solvent hydrophilicity are induced by the different water contents on the enzyme surface and not by the solvent itself...
  81. ncbi Parental occupational exposure to exhausts, solvents, glues and paints, and risk of childhood leukemia
    Alison Reid
    Western Australian Institute for Medical Research, The University of Western Australia, 35 Stirling Highway, Crawley, WA 6009, Australia
    Cancer Causes Control 22:1575-85. 2011
    ..It is unknown whether parental occupational exposure to chemicals before during and after pregnancy increases the risk of acute lymphoblastic leukemia (ALL) in the offspring. Few studies on this topic have assessed maternal exposures...
  82. ncbi Bioinformatic approaches for predicting substrates of proteases
    Jiangning Song
    Department of Biochemistry and Molecular Biology, Monash University, Victoria 3800, Australia
    J Bioinform Comput Biol 9:149-78. 2011
    ..We also provide some suggestions about how future studies might further improve the accuracy of protease substrate specificity prediction...
  83. ncbi Chemical composition of Artemisia annua L. leaves and antioxidant potential of extracts as a function of extraction solvents
    Shahid Iqbal
    Department of Chemistry, University of Sargodha, Sargodha 40100, Pakistan
    Molecules 17:6020-32. 2012
    ..annua leaves in addition to determination of antioxidant potential of their extracts prepared in different solvents. Chemical composition was determined by quantifying fat, protein, carbohydrate, fiber, tocopherol, phytate, and ..
  84. pmc Genetic variation in metabolic genes, occupational solvent exposure, and risk of non-hodgkin lymphoma
    Kathryn Hughes Barry
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    Am J Epidemiol 173:404-13. 2011
    ..Overall associations between the chlorinated solvents dichloromethane (odds ratio (OR) = 1.69, 95% confidence interval (CI): 1.06, 2.69), carbon tetrachloride (OR = 2...
  85. ncbi Critical assessment of high-throughput standalone methods for secondary structure prediction
    Hua Zhang
    Zhejiang Gongshang University, Hangzhou, Zhejiang, P R China
    Brief Bioinform 12:672-88. 2011
    ..Finally, we compare predictions of the standalone implementations of four well-performing methods with their corresponding web servers...
  86. ncbi Covalent bulk functionalization of graphene
    Jan M Englert
    Department of Chemistry and Pharmacy and Institute of Advanced Materials and Processes ZMP, University of Erlangen Nurnberg, Henkestrasse 42, 91054 Erlangen, Germany
    Nat Chem 3:279-86. 2011
    ..Functionalization was observed spectroscopically, and successfully prevents reaggregation while providing solubility in common organic media...
  87. ncbi Asymmetric bioreduction of alkenes using ene-reductases YersER and KYE1 and effects of organic solvents
    Yanto Yanto
    School of Chemical and Biomolecular Engineering, Parker H Petit Institute of Bioengineering and Biosciences, Georgia Institute of Technology, Atlanta, Georgia 30332 0363, United States
    Org Lett 13:2540-3. 2011
    ..The effects of organic solvents on enzyme activity and stereoselectivity were outlined in this study, where two-phase systems hexane and toluene ..
  88. pmc Dynamic diagnosis of familial prion diseases supports the β2-α2 loop as a universal interference target
    Massimiliano Meli
    Department of Computational Biology, Istituto di Chimica del Riconoscimento Molecolare, Consiglio Nazionale delle Ricerche, Milano, Italy
    PLoS ONE 6:e19093. 2011
  89. ncbi Trichloroethylene induces methylation of the Serca2 promoter in H9c2 cells and embryonic heart
    Brittany Palbykin
    Department of Nutritional Sciences, University of Arizona, Shantz, Tucson, AZ 85721, USA
    Cardiovasc Toxicol 11:204-14. 2011
    ..These cumulative data indicate that epigenetic mechanisms, including DNA methylation, may be important in mediating the teratogenic effects of TCE in embryonic heart...
  90. ncbi Implications of the solvent vehicles dimethylformamide and dimethylsulfoxide for establishing transcriptomic endpoints in the zebrafish embryo toxicity test
    Catherine Turner
    Institute of Integrative Biology, University of Liverpool, Liverpool, United Kingdom
    Environ Toxicol Chem 31:593-604. 2012
    Current aquatic chemical testing guidelines recognize that solvents can potentially interfere with the organism or environmental conditions of aquatic ecotoxicity tests and therefore recommend concentration limits for their use...
  91. ncbi Comparative embryotoxicity and proteotoxicity of three carrier solvents to zebrafish (Danio rerio) embryos
    Arnold Hallare
    Animal Physiological Ecology, University of Tubingen, 72072 Tubingen, Germany
    Ecotoxicol Environ Saf 63:378-88. 2006
    ..DMSO), and acetone on zebrafish embryos and the implications of the observed results on the use of these solvents to zebrafish early life stage tests. The embryos were exposed to different concentrations (0.0, 0.0001, 0.001, 0...
  92. ncbi Effects of water miscible organic solvents on the activity and conformation of the Baeyer-Villiger monooxygenases from Thermobifida fusca and Acinetobacter calcoaceticus: a comparative study
    Francesco Secundo
    Istituto di Chimica del Riconoscimento Molecolare, CNR, Milano, Italy
    Biotechnol Bioeng 108:491-9. 2011
    ..A broader exploitation of enzymes in organic synthesis can be achieved by increasing their tolerance toward organic solvents. In this study, the stability and activity of Baeyer-Villiger monooxygenases from Thermobifida fusca (PAMO) and ..
  93. ncbi Antinociceptive and acute toxicity evaluation of Vernonia condensata Baker leaves extracted with different solvents and their mixtures
    Wagner E Risso
    Department of Chemistry, State University of Londrina, 8651 980 Londrina, Parana, Brazil
    Indian J Exp Biol 48:811-6. 2010
    ..Different solvents (acetone, dichloromethane, ethanol and ethyl acetate) as well as their binary, ternary and quaternary mixtures ..
  94. ncbi RVP-net: online prediction of real valued accessible surface area of proteins from single sequences
    Shandar Ahmad
    Department of Biochemical Engineering and Science, Kyushu Institute of Technology, IZUKA, 820 8502, Fukuoka Ken, Japan and Computational Biology Research Center CBRC, AIST, 2 41 6, Koto ku, Tokyo 135 0064, Japan
    Bioinformatics 19:1849-51. 2003
    ..To facilitate batch processing of several sequences, a standalone version of this tool is also provided...
  95. ncbi Maternal occupational exposure to solvents and congenital malformations: a prospective study in the general population
    R Garlantezec
    Inserm U625, GERHM, Univ Rennes I, Campus de Beaulieu, Rennes F 35042, France
    Occup Environ Med 66:456-63. 2009
    To study the relations between maternal occupational exposure to solvents during pregnancy and the risk of congenital malformations.
  96. ncbi A novel analytical approach for reducing the consumption of organic solvents in the charge transfer-based spectrophotometric analysis: application in the analysis of certain antihypertensive drugs
    Ibrahim A Darwish
    Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia
    Acta Pharm 60:493-501. 2010
    ..describes the development of a novel analytical approach that can reduce by 50-fold the consumption of organic solvents in the charge transfer (CT)-based spectrophotometric analysis...
  97. ncbi Evaluation of methods to extract and quantify lipids from Synechocystis PCC 6803
    Jie Sheng
    Center for Environmental Biotechnology, The Biodesign Institute, Arizona State University, Tempe, AZ 85287 5701, USA
    Bioresour Technol 102:1697-703. 2011
    ..Synechocystis as a source of feedstock for carbon-neutral, nonpetroleum-based diesel fuel, we evaluated several solvents and solvent systems for their ability to extract lipid from wild-type Synechocystis PCC 6803...
  98. ncbi Constant pH molecular dynamics in generalized Born implicit solvent
    John Mongan
    The Center for Theoretical Biological Physics, University of California at San Diego, 9500 Gilman Dr, La Jolla, California 92093 0365, USA
    J Comput Chem 25:2038-48. 2004
    ..A strong correlation between conformation and protonation state is noted and quantitatively analyzed, emphasizing the importance of sampling protonation states in conjunction with dynamics...
  99. ncbi Solvent mediated interactions in the structure of the nucleosome core particle at 1.9 a resolution
    Curt A Davey
    Institut fur Molekularbiologie und Biophysik, ETH Honggerberg, CH 8093 Zurich, Switzerland
    J Mol Biol 319:1097-113. 2002
    ..Divalent cations are bound at specific sites in the nucleosome core particle and contribute to histone-histone and histone-DNA interparticle interactions. These interactions may be relevant to nucleosome association in arrays...
  100. ncbi The effects of solvents on embryonic stem cell differentiation
    S Adler
    ECVAM, Joint Research Centre, Institute for Health and Consumer Protection, via E Fermi 1, 21020 Ispra VA, Italy
    Toxicol In Vitro 20:265-71. 2006
    Dimethyl sulfoxide (DMSO) and ethanol are common organic solvents used for dissolving lipophilic substances for in vitro testing...
  101. ncbi Industrial solvents and liver toxicity: risk assessment, risk factors and mechanisms
    Nachman Brautbar
    University of Southern California, School of Medicine, Department of Medicine, 6200 Wilshire Blvd, Ste 1000, Los Angeles, CA 90048, USA
    Int J Hyg Environ Health 205:479-91. 2002
    Organic solvents utilized in various industrial processes may be associated with hepatotoxicity. The hepatotoxicity of some of the solvents was recognized as early as 1887, 1889 and 1904...

Research Grants72

  1. Nanoemulsion-based vaccine for chronic hepatitis B virus
    James R Baker; Fiscal Year: 2010
    ..adjuvants are oil-in-water emulsions prepared by high speed homogenization using innocuous surfactants and solvents as stabilizers with an average droplet size of 200-600 nm...
  2. Neural Actions of Toluene
    John J Woodward; Fiscal Year: 2013
    The use of volatile organic solvents as drugs of abuse is an important health problem. These agents, often termed abused inhalants, are voluntarily inhaled or "huffed" for their intoxicating effects...
  3. Development and testing of polyvalent anthrax toxin inhibitors
    JEREMY S MOGRIDGE; Fiscal Year: 2012
    ..will be assessed in buffers made within a clinically suitable range of pH values, and in the presence of co- solvents and surfactants...
  4. Alkylammonium Formate Mobile Phase Modifiers for Protein Liquid Chromatography
    NEIL DANIELSON; Fiscal Year: 2009
    ..class of room temperature ionic liquids, alkylammonium formates (AAFs), as mobile phase alternatives to organic solvents for liquid chromatography (LC) of proteins...
  5. Liquid Crystal-Based End-of-Service-Life-Indicator for Toluene Vapor
    BHARAT R ACHARYA; Fiscal Year: 2011 painting, automobile, textile, printing, and pharmaceutical industries are exposed to vapors from organic solvents that are recognized by National Institute of Occupational Safety and Hygiene (NIOSH) as carcinogens, reproductive ..
  6. Phospholipid Nanocarriers Improve Chemotherapy by Targeted Drug Delivery
    Hayat Onyuksel; Fiscal Year: 2010 formulate insoluble drugs in an aqueous media for parenteral (iv) use are pH adjustment and use of co solvents/surfactants that normally show vehicle related toxicities...
  7. LTQ Orbitrap XL ETD Mass Spectrometer
    Haining Zhu; Fiscal Year: 2010
    ..In particular, the splitless nano-HPLC manufactured by Eksigent Technologies uses significantly less organic solvents compared to other split-flow chromatography instruments, thus generating hundreds- to thousands-fold less ..
  8. A Miniaturized GC with MEMS-Enabled Selective Preconcentration for Monitoring Exp
    Masoud Agah; Fiscal Year: 2013
    ..and separation characteristics to enable the identification of key compounds in three classes of HAPs: aromatic solvents;polycyclic aromatic hydrocarbons, and non-aromatic hydrocarbons...
  9. Transdermal delivery of 2-Arachidonoyl glycerol (2-AG) for the treatment of arthr
    Audra L Stinchcomb; Fiscal Year: 2012
    ..2) to characterize the physicochemical parameters of the drugs, including solubilities and stabilities in select solvents, (3) to measure the penetration and concurrent bioconversion of the prodrugs in hairless guinea pig and human ..
  10. Registry Study of Parkinsons Disease in Denmark
    Beate R Ritz; Fiscal Year: 2010
    ..we will evaluate farming and greenhouse occupations (pesticides), metal related industries (metals and solvents), and night shift work (melatonin levels);2) whether certain drugs and medical conditions are positively or ..
  11. Nanoscale Optical Fiber Biosensor Assays for Detection of Category A and B Select
    Thomas J Inzana; Fiscal Year: 2010
    ..can be easily operated by non-specialist personnel and do not require high vacuum, high temperature, organic solvents, or clean-room facilities...
  12. Pooling of Prospective Studies of Diet, Lifestyle and ALS
    EILIS O'REILLY; Fiscal Year: 2013
    ..been examined epidemiologically, mainly in retrospective case-control studies: smoking, exposure to metals or solvents, trauma, and diet...
  13. Polysaccharide Ecocomposite Materials: Recyclable Synthesis and Applications
    Chieu D Tran; Fiscal Year: 2012 dissolve polysaccharides (CEL, CS and cyclodextrins (CDs)) and keratin without using harmful, volatile organic solvents and/or strong acid and base;(2) using only naturally occurring biopolymers, including polysaccharides and keratin,..
  14. Neuroplasticity Associated with Acute Toluene Inhalation
    JACOB THOMAS BECKLEY; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Volatile organic solvents, part of the abused inhalants drug class, are compounds found in common household products, such as paints, paint thinners, lacquers and glues...
  15. Hydrodynamic Chirality: A novel method for chiral separation and analysis
    Osman Kibar; Fiscal Year: 2013
    ..high fidelity absolute configuration determination of at least two chiral molecules in both polar and nonpolar solvents;and 3) Investigate design parameter tradeoffs including voltage and frequency dependence and throughput up to ..
  16. Pilot assessment of the effects of noise, lead, and cadmium on hearing in mice
    Richard L Neitzel; Fiscal Year: 2013
    ..Moreover, adverse effects of environmental contaminants (e.g., organic solvents) can be aggravated by concurrent exposure to noise which is present in many environments contaminated with heavy ..
    James R Halpert; Fiscal Year: 2013
    ..Such compounds, including natural products and organic solvents, generally occur in mixtures, and it is often not clear how one compound can modulate the detoxification and ..
  18. Boronated nucleosides for neutron capture therapy of brain tumors
    Werner Tjarks; Fiscal Year: 2013 the substrate-binding site of TK1 and (2) the lack of water-solubility, which necessitated the use of organic solvents to solubilize 3CTAs for biological studies...
  19. Enhanced Recovery of Pharmaceutical Solvent driven by EPA Initiative
    JOHN J BOWSER; Fiscal Year: 2013
    ..On average, pharmaceutical manufacturers use at least 100 kg of solvents to make 1 kg of active pharmaceutical ingredient...
  20. New Leads Against Cancer and Infectious Diseases from Puerto Rican Reef Species
    Abimael D Rodriguez; Fiscal Year: 2013
    ..Initial extraction with solvents of different polarities (e.g...
  21. Prevention of Metastatic Cancer Using a Novel Vitamin E Analog
    Emmanuel T Akporiaye; Fiscal Year: 2010
    ..a-TEA chemotherapy to the clinic has been hampered by its lipid solubility that requires dissolving it in organic solvents that are impractical for use in humans...
  22. Multicolor Cell Membrane Profiling For Development And Disease
    BRIAN DAVID GRAY; Fiscal Year: 2013
    ..are not permanently bound to the membranes and can either leak out or be easily washed away by lipophilic solvents or detergents. Attempts to overcome these problems have thus far been at best partially successful...
    Audra L Stinchcomb; Fiscal Year: 2010
    ..volume, lipophilicity, hydrogen-bonding potentials, melting points, heats of fusion, and solubilities in select solvents, (3) to measure the drugs'penetration and concurrent bioconversion through human skin in vitro with and ..
  24. Rational Design of Lipidic Vectors for Mitochondria-Targeted Antioxidants
    Song Li; Fiscal Year: 2013
    ..Organic solvents such as ethanol, DMSO, Cremophor EL/ethanol had to be used in the past for the assessment of their in vivo ..
  25. Neurotoxic effects of solvents on working children
    Iman A Nuwayhid; Fiscal Year: 2011
    ..Hence, exposure of millions of adolescent working children in developing countries to solvents might affect their cognitive and behavioral development, in a previous original study in Lebanon, we reported ..
  26. Pesticide Exposure and DNA Methylation in Pesticide Applicators
    JENNIFER ANN RUSIECKI; Fiscal Year: 2010
    ..Our secondary aims are to explore whether other farm related exposures, such as solvents, grain dust, welding fumes, and high pesticide exposure events modify the associations between pesticide ..
  27. UPRH Biomedical Research Improvement Program
    Antonio E Alegria; Fiscal Year: 2010
    ..the purpose of understanding and improving enzyme's activity, stability and enantioselectivity in organic solvents for the small and large scale synthesis of bio-relevant compounds...
  28. Iron oxide nanoparticle probes for target specific MR molecular imaging
    Y Andrew Wang; Fiscal Year: 2010
    ..Recent advances in iron oxide synthesis in organic solvents at elevated reaction temperature allow the preparation of size tunable and monodisperse particles...
  29. Low-Coordinate Synthetic Models for Nitrogenase Activity
    Patrick L Holland; Fiscal Year: 2013
    ..The bulky groups also facilitate crystallization, and enhance solubility in organic solvents that can be used at low temperature...
  30. Sensitivity enhancement in solution NMR through dynamic nuclear polarization
    A Joshua Wand; Fiscal Year: 2013
    ..will take advantage of the physical properties of solutions of encapsulated proteins dissolved in low viscosity solvents of suitable dielectric character...
  31. Photodegradation Reactions Mono and Dinitro PAHs
    Rafael Arce; Fiscal Year: 2011
    ..relative yields, and to compare their relative yields and distribution with those obtained in the different solvents. The effect of coadsorbed water and oxygen on the yields will also be examined and (3) identify and characterize ..
  32. Multiplexed Onchip Nanomagnetic Immunoassay for TOxin Reporting (MONITOR)
    John Collins; Fiscal Year: 2012
    ..and other toxins that are found in the environment are relatively insoluble in water but soluble in many organic solvents and especially soluble in the fatty tissues...
  33. Reactive Metabolites in Drug Toxicity
    Robert P Hanzlik; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Many simple organic molecules including solvents, agrichemicals, drugs and drug candidates become cytotoxic upon biotransformation to reactive electrophilic metabolites...
  34. Functionalized Micellar Nanocarriers for Targeted Cancer Therapy
    Chalet Tan; Fiscal Year: 2010
    ..In addition, serious toxicities may be associated with the organic solvents/surfactants that are used to dissolve the highly lipophilic drug molecules...
  35. Complementary and Alternative Medicine Detoxification: Safety and Efficacy
    Jason Allen; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Exposure to synthetic chemicals, including pesticides, solvents, and flame retardants, is associated with the initiation or exacerbation of a number of human diseases, including cancer, autoimmune ..
  36. Hybrid Inorganic-Organic Hydrogel Scaffolds for Osteochondral Regeneration
    Mariah S Hahn; Fiscal Year: 2013
    ..Fabrication solvents of varying polarities will be used tailor PDMS distribution and porosity...
  37. Complementary and Alternative Medicine Detoxification: Safety and Efficacy
    Jason Allen; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Exposure to synthetic chemicals, including pesticides, solvents, and flame retardants, is associated with the initiation or exacerbation of a number of human diseases, including cancer, autoimmune ..
  38. Solvent-free engineering of a shape-specific osteochondral TMJ condyle
    MICHAEL SCOTT DETAMORE; Fiscal Year: 2010
    ..application is to regenerate a patient-specific temporomandibular joint (TMJ) condyle using a process free of solvents, particulates and polymerization initiators...
  39. Structure, Dynamics, and Functions of the Viroporins Vpu from HIV and p7 from HCV
    Stanley J Opella; Fiscal Year: 2013
    ..have learned from our studies of membrane proteins is that they are distorted by membrane mimics, such as organic solvents and detergent micelles, and must be studies in their native phospholipid bilayer environment under physiological ..
  40. Chemical and Toxicological Analysis of Air Quality Using a Novel Device
    CHRISTOPHER H PRICE; Fiscal Year: 2013 exposures to living cultured human lung cells to gases and particles without pre-collection or the use of solvents. This is accomplished through electrostatic charging that efficiently deposits particles directly onto living ..
  41. Low-Cost Electronic Nose for Groundwater Contaminants
    Sanjay V Patel; Fiscal Year: 2012
    ..feasibility of using a microsensor array with a proprietary trap-and- purge preconcentrator to detect chlorinated solvents, specifically TCE, and TCA, at levels low enough to meet EPA mandated levels for drinking water...
  42. Discriminative stimulus effects of abused inhalants
    Keith L Shelton; Fiscal Year: 2013
    ..We will subsequently conduct cross-tests among these four compounds as well as with other representative volatile solvents and volatile anesthetics. We hypothesize that these cross-tests will reveal several distinct inhalant groups...
  43. Genetic and Chemically Programmed Nanoparticles for Prodrug Therapy
    M G Finn; Fiscal Year: 2013
    ..coli in high yield and purity, is very stable toward heat, variable pH, organic solvents, and conditions of chemical modification...
  44. Novel Nanofiltration Membranes for Isolation of Pharmaceutical Compounds
    Ning Shangguan; Fiscal Year: 2011
    ..In the chemical manufacturing of pharmaceutical compounds, organic syntheses are often carried out in organic solvents and involve intermediates and final products with high added value...
  45. Novel Nanofiltration Membranes for Isolation of Pharmaceutical Compounds
    Ning Shangguan; Fiscal Year: 2012
    ..In the chemical manufacturing of pharmaceutical compounds, organic syntheses are often carried out in organic solvents and involve intermediates and final products with high added value...
    ROBIN MAIN HOCHSTRASSER; Fiscal Year: 2011
    ..sensitivities, angular distributions and couplings representative of protein secondary structures in different solvents and comparisons with those found in gases and molecular dynamics simulations...
  47. Trichloroethylene and Parkinson's Disease
    Samuel M Goldman; Fiscal Year: 2013
    ..The chlorinated solvents tetrachloroethylene (PERC, perchloroethylene) and carbon tetrachloride (CCl4) were also associated...
  48. Regiocontrolled Intermolecular Hydroamination of Olefins
    SARAH MARIE BRONNER; Fiscal Year: 2013
    ..Due to the enormous prevalence of amines in therapeutics, as well as in the production of dyes, solvents, agrochemicals, and commodity and fine chemicals, the formation of carbon-nitrogen bonds is of paramount ..
  49. Enhanced Formalin Fixation to Improve Tests on Solid Tissues
    Margaret L Gulley; Fiscal Year: 2012
    ..dehydration step, yet are poorly soluble in alcohol or xylene so that, upon tissue transfer into water-free solvents, the scavengers are embedded in the dehydrated tissue block matrix where they stand ready to quench newly-formed ..
  50. Multiple Myeloma Consortium Study of Occupational Exposures and Family History
    Anneclaire J De Roos; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Exposure to solvents is widespread, both in certain occupations and in the general environment...
  51. Advantages of HPLC with Ultra Stable Phases
    Peter W Carr; Fiscal Year: 2011
    ..We will explore the potential of unusual RPLC solvents and a 23 novel stationary phase for optimizing the first separation dimension...
    Aneel K Aggarwal; Fiscal Year: 2010
    ..In the presence of certain co-solvents, most restriction enzymes show enhanced cleavage at non-cognate sites, the so-called "star" activity...
  53. Self-microencapsulation in polymer delivery systems without organic solvents
    Steven P Schwendeman; Fiscal Year: 2010
    ..acid) (PLGA) suffer from: a) protein instability including use of protein-denaturing organic solvents, b) expensive large-scale, aseptic processing for encapsulation of each peptide/protein of interest, and c) the ..
  54. Structural and Functional Studies of Channels and Pumps by Solid State NMR
    Ann E McDermott; Fiscal Year: 2012
    ..Solution NMR studies have shown that the c subunit monomer in organic solvents is a helical hairpin whose interhelical loop structure is a function of pH...
  55. Design of Therapeutic Peptide-Based Nanoparticles
    Vadim V Gaponenko; Fiscal Year: 2013
    ..Utilization of structural plasticity of peptide molecules in biological solvents is a novel approach to solve the problems with peptide pharmaceutical agents...
  56. Self-Assembled Encapsulated Enzymes for Pharmaceutical Synthesis
    JASON FIEDLER; Fiscal Year: 2012
    ..However, enzymes are sensitive to elevated temperatures and the presence of co-solvents, and are often not optimal in terms of rate, lifetime, product inhibition, and substrate acceptance...
  57. Effects-Related Biomarkers of Environmental Neurotoxic Exposures
    Evan P Gallagher; Fiscal Year: 2013
    ..effects of metals and pesticides in free-living Coho salmon;and, 5) phytoremediation methods for organic solvents and pesticides...
  58. Rapid detection of toxic petroleum residues in seafood
    JOSEPH FRANCIS KREBS; Fiscal Year: 2013
    ..To enable dockside testing and eliminate the use of toxic organic solvents, we will create a novel detergent-based method to process seafood samples...
  59. Contrast agents for high-sensitivity ultrasound molecular imaging of tumor angiog
    Joshua J Rychak; Fiscal Year: 2011
    ..We hypothesize that controlled dissolution of the lipid MB shell, by incubation in varying strength organic solvents, will enable us to reduce the mean diameter of this agent...
    JUSTIN MICHAEL WISEMAN; Fiscal Year: 2013
    ..the milestones we propose: making appropriate hardware changes, determining analytical metrics corresponding to solvents and probe sizes, and gathering a statistically relevant number of profiles for bacterial analysis, the capacity ..
  61. Puerto Rico Testsite for Exploring Contamination Threats (PRoTECT)
    Akram N Alshawabkeh; Fiscal Year: 2013
    ..The targeted studies focus on chlorinated solvents and phthalates because they are suspect and model contaminants and because they are found in many Superfund sites ..
  62. Development of Carbamate Amination Methodology and Synthesis of Levofloxacin
    ..using nickel(0) precatalysts, optimization of Ni(II) sources will be undertaken by varying ligands, bases, solvents, and temperature...
    Andrew Streitwieser; Fiscal Year: 1999
    ..of drugs and other biologically active molecules and that the reaction is now most often run in non-polar solvents, such as tetrahydrofuran (THF), frequently with lithium salts of carbonyl compounds (lithium enolates)...
    Ronald Wood; Fiscal Year: 1991
    ..and toxicity syndromes; assess irritancy and its consequences; and characterize direct behavioral effects of solvents. Inhalants self-administration by the monkey...
  65. Echinacea: Standardized Product & Supply Provision
    Xiping Wang; Fiscal Year: 2004
    ..and testing methods; 3) marker compound testing to identify promising end products using different extraction solvents and strategy (i.e...
  66. Prevention of Head and Neck Carcinogenesis with a Plant-Derived Compound
    Rebecca Leeman; Fiscal Year: 2009
    ..thought to be caused by the effects of environmental carcinogens including tobacco, alcohol, betel quid, organic solvents, coal dust, welding fumes, asbestos, and polycyclic aromatic hydrocarbons...
    Mary Haasch; Fiscal Year: 2001
    ..PPAs are a structurally-diverse group of chemicals including herbicides, solvents, and plasticizers, that are known fatty acid, retinoid and endocrine disrupters...
    Melissa Runge Morris; Fiscal Year: 1991
    b>Solvents such as benzene, trichloroethylene, and ethanol are widely employed in a variety of industrial and research laboratory settings. Volatile nitrogenous bases, for which pyridine is prototypic, are also utilized in these settings...
    PAUL BLATZ; Fiscal Year: 1990
    ..donor reagents such as phenol, substituted phenols, acetic acid and chloro substituted acetic acids, ii) selected solvents such as hydrocarbons and chlorohydrocarbons, and iii) changing temperature...
    Paolo Vineis; Fiscal Year: 1993
    Exposures to organic solvents (including benzene), ionizing radiation and low-frequency electromagnetic fields have been suggested as risk factors for leukemias in adults...
    Isaac Lipkus; Fiscal Year: 2003
    ..Carpenters are exposed to occupational health hazards (e.g., asbestos, wood dust, solvents) and engage in lifestyle behaviors (e.g., smoking, alcohol use) that may increase their CRC risk...
  72. Organic Solvent Mixtures & Neuropsychological Outcomes
    Ellen Kirrane; Fiscal Year: 2002
    ..lack of information on health hazards in this industry, fishers are known to be exposed to a variety of organic solvents including evaporative emissions from fuel and fuel exhaust, styrene and acetone during fiberglass work, paints ..