radiation protective agents

Summary

Summary: Drugs used to protect against ionizing radiation. They are usually of interest for use in radiation therapy but have been considered for other, e.g. military, purposes.

Top Publications

  1. ncbi Evaluation of radioprotective effects of Rajgira (Amaranthus paniculatus) extract in Swiss albino mice
    Anita Krishna
    Radiation and Cancer Biology Laboratory, Department of Zoology, University of Rajasthan, Jaipur, India
    J Radiat Res 46:233-9. 2005
  2. ncbi Radioprotection by oral administration of Aegle marmelos (L.) Correa in vivo
    Ganesh Chandra Jagetia
    Department of Radiobiology, Kasturba Medical College, Manipal, Karnataka, India
    J Environ Pathol Toxicol Oncol 24:315-32. 2005
  3. ncbi Effect of sesamol on radiation-induced cytotoxicity in Swiss albino mice
    Vipan Kumar Parihar
    Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal 576104, India
    Mutat Res 611:9-16. 2006
  4. ncbi Radioprotection by plant products: present status and future prospects
    Rajesh Arora
    Division of Radiopharmaceuticals and Radiation Biology, Institute of Nuclear Medicine and Allied Sciences, Defence Research and Development Organization, Brig SK Mazumdar Road, Delhi 110 054, India
    Phytother Res 19:1-22. 2005
  5. ncbi Trends in the development of radioprotective agents
    Seyed Jalal Hosseinimehr
    Department of Medicinal Chemistry, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
    Drug Discov Today 12:794-805. 2007
  6. ncbi Prophylactic use of amifostine to prevent radiochemotherapy-induced mucositis and xerostomia in head-and-neck cancer
    Dosia Antonadou
    Radiation Oncology Department, Metaxa s Cancer Hospital, Piraeus, Greece
    Int J Radiat Oncol Biol Phys 52:739-47. 2002
  7. ncbi Phase III randomized trial of amifostine as a radioprotector in head and neck cancer
    D M Brizel
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    J Clin Oncol 18:3339-45. 2000
  8. ncbi Gamma-tocotrienol, a tocol antioxidant as a potent radioprotector
    Sanchita P Ghosh
    Armed Forces Radiobiology Research Institute, USUHS, Bethesda, USA
    Int J Radiat Biol 85:598-606. 2009
  9. ncbi Amifostine: the first selective-target and broad-spectrum radioprotector
    John R Kouvaris
    Aretaieion Hospital University of Athens, Department of Radiology, 76 Vas Sophias Avenue, Athens 11528, Greece
    Oncologist 12:738-47. 2007
  10. ncbi A phase I study of topical Tempol for the prevention of alopecia induced by whole brain radiotherapy
    James M Metz
    Department of Radiation Oncology, University of Pennsylvania, Philadelphia 19104 4283, USA
    Clin Cancer Res 10:6411-7. 2004

Detail Information

Publications244 found, 100 shown here

  1. ncbi Evaluation of radioprotective effects of Rajgira (Amaranthus paniculatus) extract in Swiss albino mice
    Anita Krishna
    Radiation and Cancer Biology Laboratory, Department of Zoology, University of Rajasthan, Jaipur, India
    J Radiat Res 46:233-9. 2005
    ....
  2. ncbi Radioprotection by oral administration of Aegle marmelos (L.) Correa in vivo
    Ganesh Chandra Jagetia
    Department of Radiobiology, Kasturba Medical College, Manipal, Karnataka, India
    J Environ Pathol Toxicol Oncol 24:315-32. 2005
    ..The drug was nontoxic up to a dose of 6000 mg/kg b.wt., the highest drug dose that could be tested for acute toxicity...
  3. ncbi Effect of sesamol on radiation-induced cytotoxicity in Swiss albino mice
    Vipan Kumar Parihar
    Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal 576104, India
    Mutat Res 611:9-16. 2006
    ..There was no protection at a dose less than 25mg/kg bw...
  4. ncbi Radioprotection by plant products: present status and future prospects
    Rajesh Arora
    Division of Radiopharmaceuticals and Radiation Biology, Institute of Nuclear Medicine and Allied Sciences, Defence Research and Development Organization, Brig SK Mazumdar Road, Delhi 110 054, India
    Phytother Res 19:1-22. 2005
    ....
  5. ncbi Trends in the development of radioprotective agents
    Seyed Jalal Hosseinimehr
    Department of Medicinal Chemistry, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
    Drug Discov Today 12:794-805. 2007
    ..Although recent agents have lower efficacy, they have lower toxicity, more favourable administration routes and improved pharmacokinetics compared to the older thiol compounds...
  6. ncbi Prophylactic use of amifostine to prevent radiochemotherapy-induced mucositis and xerostomia in head-and-neck cancer
    Dosia Antonadou
    Radiation Oncology Department, Metaxa s Cancer Hospital, Piraeus, Greece
    Int J Radiat Oncol Biol Phys 52:739-47. 2002
    ..To determine the prophylactic properties of amifostine against acute and late toxicities from radiochemotherapy in patients with head-and-neck cancer...
  7. ncbi Phase III randomized trial of amifostine as a radioprotector in head and neck cancer
    D M Brizel
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    J Clin Oncol 18:3339-45. 2000
    ..This randomized trial evaluated whether amifostine could ameliorate these side effects without compromising the effectiveness of radiotherapy in these patients...
  8. ncbi Gamma-tocotrienol, a tocol antioxidant as a potent radioprotector
    Sanchita P Ghosh
    Armed Forces Radiobiology Research Institute, USUHS, Bethesda, USA
    Int J Radiat Biol 85:598-606. 2009
    ..To assess the radioprotective potential of gamma-tocotrienol...
  9. ncbi Amifostine: the first selective-target and broad-spectrum radioprotector
    John R Kouvaris
    Aretaieion Hospital University of Athens, Department of Radiology, 76 Vas Sophias Avenue, Athens 11528, Greece
    Oncologist 12:738-47. 2007
    ..This review summarizes the clinical experience with amifostine and provides insight into future clinical directions...
  10. ncbi A phase I study of topical Tempol for the prevention of alopecia induced by whole brain radiotherapy
    James M Metz
    Department of Radiation Oncology, University of Pennsylvania, Philadelphia 19104 4283, USA
    Clin Cancer Res 10:6411-7. 2004
    ..This phase Ib study was designed to evaluate the safety and side effect profile of topical Tempol in patients with brain metastases being treated with whole brain radiotherapy...
  11. ncbi Subcutaneous administration of amifostine during fractionated radiotherapy: a randomized phase II study
    M I Koukourakis
    Department of Radiotherapy Oncology and Medical Oncology, University Hospital of Iraklion, Greece
    J Clin Oncol 18:2226-33. 2000
    ..The subcutaneous route, due to its simplicity, presents multiple advantages over the intravenous route when amifostine is used during fractionated radiotherapy...
  12. ncbi Prophylactic effect of pentoxifylline on radiotherapy complications: a clinical study
    Erdinc Aygenc
    Department of Otorhinolaryngology Head and Neck Surgery, Department of Numune Research and Educational Hospital, Ankara, Turkey
    Otolaryngol Head Neck Surg 130:351-6. 2004
    ..The purpose of this study was to assess the prophylactic effect of pentoxifylline (Ptx) on complications related to radiation...
  13. ncbi Protective effect of triphlorethol-A from Ecklonia cava against ionizing radiation in vitro
    Kyoung Ah Kang
    Department of Biochemistry, College of Medicine and Applied Radiological Science Research Institute, Cheju National University, Jeju Si, Korea
    J Radiat Res 47:61-8. 2006
    ..Taken together, the results suggest that triphlorethol-A protects cells against oxidative damage induced by radiation through reducing ROS...
  14. ncbi Genistein treatment protects mice from ionizing radiation injury
    Michael R Landauer
    Radiation Casualty Management Team, Armed Forces Radiobiology Research Institute, 8901 Wisconsin Avenue, Bethesda, MD 20889 5603, USA
    J Appl Toxicol 23:379-85. 2003
    ..These results demonstrate that a single s.c. administration of the flavonoid genistein at non-toxic doses provides protection against acute radiation injury...
  15. ncbi Amifostine in clinical oncology: current use and future applications
    M I Koukourakis
    Department of Radiation Oncology, Democritus University of Thrace, Alexandroupolis 68100, Greece
    Anticancer Drugs 13:181-209. 2002
    ..Novel schedules and routes of administration are under investigation, and may further simplify the use of amifostine and considerably broaden its applications...
  16. ncbi Relevance of radioprotectors in radiotherapy: studies with tocopherol monoglucoside
    Cherupally Krishnan K Nair
    Radiation Biology and Health Sciences Division, Bhabha Atomic Research Centre, Bombay, India
    J Environ Pathol Toxicol Oncol 23:153-60. 2004
    ..Administration of TMG did not protect cancer cells from radiation damage because the growth curves of cancer cells treated with radiation alone and those treated with TMG after irradiation were not significantly different...
  17. ncbi Radiation countermeasure agents: an update
    Francis Dumont
    Universite de Strasbourg, Centre Regional de Lutte Contre le Cancer Paul Strauss, Laboratoire de Radiobiologie EA 3430, 3 rue de la porte de l Hôpital, F 67065 Strasbourg, France
    Expert Opin Ther Pat 20:73-101. 2010
    ..There is, therefore, a pressing need to develop safe and effective radiation countermeasure (RC) agents to prevent, mitigate or treat the harmful consequences of IR exposure...
  18. ncbi Protective effect of phlorotannin components phloroglucinol and eckol on radiation-induced intestinal injury in mice
    Changjong Moon
    College of Veterinary Medicine, Chonnam National University, Gwangju 500 757, South Korea
    Phytother Res 22:238-42. 2008
    ....
  19. ncbi Melatonin and protection from whole-body irradiation: survival studies in mice
    - Vijayalaxmi
    Department of Radiology Division of Radiation Oncology, The University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78284, USA
    Mutat Res 425:21-7. 1999
    ..0080). These results indicate that melatonin (at a dose as high as 250 mg/kg) is non-toxic, and that high doses of melatonin are effective in protecting mice from lethal effects of acute whole-body irradiation...
  20. pmc Modulation with cytokines of radiation injury: suggested mechanisms of action
    R Neta
    Office of International Health Programs, U S Department of Energy, Germantown, MD 20874, USA
    Environ Health Perspect 105:1463-5. 1997
    ..Thus, the insights gained from such studies at the whole-animal level promise a better understanding of the membrane and intracellular events associated with radiation damage and repair of such damage...
  21. ncbi Checkpoint kinase inhibitors: SAR and radioprotective properties of a series of 2-arylbenzimidazoles
    Kristen L Arienti
    Johnson and Johnson Pharmaceutical Research and Development, L L C, 3210 Merryfield Row, San Diego, California 92121, USA
    J Med Chem 48:1873-85. 2005
    ..This work suggests that a selective small molecule inhibitor of chk2 could be a useful adjuvant to radiotherapy, increasing the therapeutic window of such treatment...
  22. ncbi Pharmacological prevention of radiation-induced dry eye-an experimental study in a rabbit model
    Julia Beutel
    Department of Ophthalmology, University Hospital Schleswig Holstein, Luebeck, Germany
    Graefes Arch Clin Exp Ophthalmol 245:1347-55. 2007
    ..To evaluate the radioprotective effect of lidocaine, amifostine and pilocarpine on lacrimal glands...
  23. ncbi The polyhydroxylated fullerene derivative C60(OH)24 protects mice from ionizing-radiation-induced immune and mitochondrial dysfunction
    Xiaoqing Cai
    Laboratory of Physical Biology, Shanghai Institure of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China
    Toxicol Appl Pharmacol 243:27-34. 2010
    ....
  24. ncbi Radioprotective potential of ginseng
    Tung Kwang Lee
    Department of Radiation Oncology, Leo W Jenkins Cancer Center, Brody School of Medicine at East Carolina University, Greenville, NC 27858, USA
    Mutagenesis 20:237-43. 2005
    ....
  25. ncbi Future strategies for mitigation and treatment of chronic radiation-induced normal tissue injury
    John E Moulder
    Radiation Oncology and Medicine, Medical College of Wisconsin, Milwaukee, WI, USA
    Semin Radiat Oncol 17:141-8. 2007
    ....
  26. ncbi Radioprotection and radiosensitization by curcumin
    Ganesh C Jagetia
    Department of Radiobiology, Kasturba Medical College, Manipal, India
    Adv Exp Med Biol 595:301-20. 2007
    ....
  27. ncbi Radiation protection by a new chemical entity, Ex-Rad: efficacy and mechanisms
    Sanchita P Ghosh
    Armed Forces Radiobiology Research Institute, USUHS, Bethesda, Maryland 20889 5603, USA
    Radiat Res 171:173-9. 2009
    ..In conclusion, it appears that Ex-Rad's radioprotective mechanisms involve prevention of p53-dependent and independent radiation-induced apoptosis...
  28. pmc Radioprotective effects of an acidic polysaccharide of Panax ginseng on bone marrow cells
    Hyun Ji Kim
    Department of Veterinary Medicine, College of Applied Life Sciences, Cheju National University, Jeju 690 756, Korea
    J Vet Sci 8:39-44. 2007
    ..Overall, this study shows that APG alters the phenotype of BMs, increases the viability and alloreactivity of BMs after gamma radiation both in vitro and in vivo. Therefore, APG may be a good candidate radioprotective agent for BMs...
  29. ncbi In vivo radioprotection by the fullerene nanoparticle DF-1 as assessed in a zebrafish model
    Borbala Daroczi
    Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107 5097, USA
    Clin Cancer Res 12:7086-91. 2006
    ..Here, we evaluated the radioprotective effect of the nanoparticle DF-1, a fullerene with antioxidant properties, in zebrafish embryos...
  30. ncbi Randomized phase III trial of radiation treatment +/- amifostine in patients with advanced-stage lung cancer
    D Antonadou
    Radiation Oncology Department, Metaxas Cancer Hospital, Pireus, Greece
    Int J Radiat Oncol Biol Phys 51:915-22. 2001
    ..This multicenter trial investigated whether daily pretreatment with amifostine (A) could reduce the incidence of acute and late lung toxicity and esophagitis without affecting antitumor efficacy of radiation in advanced lung cancer...
  31. ncbi Pentoxifylline and alpha-tocopherol in prevention of radiation-induced lung toxicity in patients with lung cancer
    Cem H Misirlioglu
    Department of Radiation Oncology, Ankara Oncology Hospital, Ankara, Turkey
    Med Oncol 24:308-11. 2007
    ..042, subacute phase P = 0.0001, late phase P = 0.256). PTX and Vit E combination might be considered especially in patients with lung cancer who receive concurrent chemo-radiotherapy, or have a poor respiratory function tests...
  32. ncbi Small molecular inhibitor of transforming growth factor-beta protects against development of radiation-induced lung injury
    Mitchell S Anscher
    Department of Radiation Oncology, Virginia Commonwealth University School of Medicine, Richmond, VA 23298 0058, USA
    Int J Radiat Oncol Biol Phys 71:829-37. 2008
    ..To determine whether an anti-transforming growth factor-beta (TGF-beta) type 1 receptor inhibitor (SM16) can prevent radiation-induced lung injury...
  33. pmc Simvastatin ameliorates radiation enteropathy development after localized, fractionated irradiation by a protein C-independent mechanism
    Junru Wang
    Department of Surgery, Central Arkansas Veterans Healthcare System, Little Rock, AR 72205, USA
    Int J Radiat Oncol Biol Phys 68:1483-90. 2007
    ..We examined whether administration of simvastatin ameliorates intestinal radiation injury, and whether the effect depends on protein C activation...
  34. ncbi Modification of radiation injury by ramipril, inhibitor of angiotensin-converting enzyme, on optic neuropathy in the rat
    Jae Ho Kim
    Departments of Radiation Oncology, Neurosurgery and Medicine, Henry Ford Health System, Detroit, MI 48202, USA
    Radiat Res 161:137-42. 2004
    ..The study represents the first demonstration of prophylaxis of radiation injury by a carboxyl-containing ACE inhibitor, providing a pharmacological strategy designed to reduce radiation-induced normal tissue damage...
  35. ncbi Differential radiation protection of salivary glands versus tumor by Tempol with accompanying tissue assessment of Tempol by magnetic resonance imaging
    Ana P Cotrim
    Gene Therapy and Therapeutics Branch, National Institute of Dental and Craniofacial Research, NIH, Bethesda, Maryland 20892, USA
    Clin Cancer Res 13:4928-33. 2007
    ..Mechanistic information was explored by monitoring the presence and bioreduction of Tempol in both tissues noninvasively by magnetic resonance imaging (MRI)...
  36. ncbi Differential protection by nitroxides and hydroxylamines to radiation-induced and metal ion-catalyzed oxidative damage
    Sandhya Xavier
    Radiation Biology Branch, National Cancer Institute, Bldg 10, Room B3 B69, 9000 Rockville Pike, Bethesda, MD 20892 1002, USA
    Biochim Biophys Acta 1573:109-20. 2002
    ....
  37. ncbi Aloe polysaccharides mediated radioprotective effect through the inhibition of apoptosis
    Zong wei Wang
    Department of Pharmacology, Guangzhou University of Traditional Chinese Medicine School of Pharmaceutical Science, Guangzhou, P R China
    J Radiat Res 45:447-54. 2004
    ..5 Gy irradiation provided the best radioprotective effect and improved the 30-day survival rate of mice to 86.0%, from 10.0%. AP exerted radioprotective effects in vitro and in vivo through an inhibition of apoptosis...
  38. ncbi American Society of Clinical Oncology 2008 clinical practice guideline update: use of chemotherapy and radiation therapy protectants
    Martee L Hensley
    Memorial Sloan Kettering Cancer Center, New York, NY, USA
    J Clin Oncol 27:127-45. 2009
    ..To update a clinical practice guideline on the use of chemotherapy and radiation therapy protectants for patients with cancer...
  39. ncbi In Vivo radioprotective effect of Panax ginseng C.A. Meyer and identification of active ginsenosides
    Hae June Lee
    College of Veterinary Medicine, Chonnam National University, Gwangju, South Korea
    Phytother Res 20:392-5. 2006
    ..When the same experiments were performed using PD and PT, it was observed that most of the inhibitory effects came from PD rather than PT...
  40. ncbi WR-2721 (amifostine, ethyol) prevents motor and morphological changes induced by neonatal X-irradiation
    L R Guelman
    1a Cátedra de Farmacología, Facultad de Medicina, Universidad de Buenos Aires UBA, Paraguay 2155 piso 15 1121, Argentina
    Neurochem Int 42:385-91. 2003
    ..Clinical implications of this model are related to the daily exposure of many people to different sources of radiation (accidental, diagnostical or therapeutical)...
  41. ncbi Antioxidant and radioprotective properties of an Ocimum sanctum polysaccharide
    Mahesh Subramanian
    Bio Organic Division, Bhabha Atomic Research Centre, Mumbai, India
    Redox Rep 10:257-64. 2005
    ..In addition, OSP could prevent gamma-radiation-mediated cell deaths in mouse splenocytes...
  42. ncbi Serious adverse effects of amifostine during radiotherapy in head and neck cancer patients
    Dirk Rades
    Department of Radiation Oncology, University Hospital Hamburg Eppendorf, Martinistrasse 52, Hamburg D 20246, Germany
    Radiother Oncol 70:261-4. 2004
    ..This is the first report focusing on amifostine related adverse effects leading to discontinuation of amifostine treatment...
  43. ncbi Does amifostine have a role in chemoradiation treatment?
    David M Brizel
    Department of Radiation Oncology at Duke University Medical Center, NC, USA
    Lancet Oncol 4:378-81. 2003
    ....
  44. ncbi Comparison of the protective effects of melatonin and amifostine on radiation-induced epiphyseal injury
    Erkan Topkan
    Baskent University Medical Faculty, Adana Medical and Research Center, Department of Radiation Oncology, Kisla Saglik Yerleskesi, Adana, Turkey
    Int J Radiat Biol 84:796-802. 2008
    ..We compared the effects of amifostine and melatonin in preventing radiation-induced epiphyseal growth plate injury in rats...
  45. ncbi Melatonin and roentgen irradiation-induced acute radiation enteritis in Albino rats: an animal model
    Mahmoud R Hussein
    Department of Pathology, Faculty of Medicine, Assuit University, Assuit, Egypt
    Cell Biol Int 32:1353-61. 2008
    ..Although roentgen rays are widely used for both imaging and therapeutic purposes, our knowledge about the morphological changes associated with radiation enteritis is lacking...
  46. ncbi Radioprotective effects of ginsan, an immunomodulator
    Jie Young Song
    Laboratory of Immunology, Korea Institute of Radiological and Medical Sciences, KAERI, 215 4, Gongneung dong, Nowon Ku, Seoul, 139 706, Korea
    Radiat Res 159:768-74. 2003
    ..54 Gy for PBS injection to 10.93 Gy for mice pretreated with 100 mg/kg ginsan was observed. These findings indicate that ginsan may be a useful agent to reduce the time necessary for reconstituting hematopoietic cells after irradiation...
  47. ncbi 2002 update of recommendations for the use of chemotherapy and radiotherapy protectants: clinical practice guidelines of the American Society of Clinical Oncology
    Lynn M Schuchter
    American Society of Clinical Oncology, Alexandria, VA 22314, USA
    J Clin Oncol 20:2895-903. 2002
  48. ncbi Protective effect of amifostine during fractionated radiotherapy in patients with pelvic carcinomas: results of a randomized trial
    Helen Athanassiou
    Department of Radiation Oncology, Agioi Anargyri Hospital, Athens, Greece
    Int J Radiat Oncol Biol Phys 56:1154-60. 2003
    ..To evaluate whether pretreatment with amifostine can reduce treatment-induced toxicity in patients with pelvic malignancies undergoing radiotherapy (RT)...
  49. ncbi Photoprotective and anti-skin-aging effects of eicosapentaenoic acid in human skin in vivo
    Hyeon Ho Kim
    Department of Dermatology, Seoul National University College of Medicine, Laboratory of Cutaneous Aging Research, Clinical Research Institutes, Seoul National University Hospital, Seoul National University, Korea
    J Lipid Res 47:921-30. 2006
    ..Together, these results demonstrate that topical EPA has potential as an anti-skin-aging agent...
  50. pmc Protective effects of epigallocatechin gallate after UV irradiation in cultured human retinal pigment epithelial cells
    Seong Won Yang
    Department of Ophthalmology, Chosun University College of Medicine, Gwangju, Korea
    Korean J Ophthalmol 21:232-7. 2007
    ..To evaluate the protective effects of Epigallocatechin gallate (EGCG) against UV irradiation in cultured human retinal pigment epithelial (RPE) cells...
  51. ncbi Manganese superoxide dismutase (SOD2)-mediated delayed radioprotection induced by the free thiol form of amifostine and tumor necrosis factor alpha
    Jeffrey S Murley
    Department of Radiation and Cellular Oncology, University of Chicago, Illinois 60637, USA
    Radiat Res 167:465-74. 2007
    ..It can be induced by a range of agents including cytoprotective nonprotein thiols such as WR-1065 and pleiotropic cytokines such as TNFalpha...
  52. ncbi Ethyl pyruvate, a potentially effective mitigator of damage after total-body irradiation
    Michael Epperly
    Department of Radiation Oncology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Radiat Res 168:552-9. 2007
    ..EP may be an effective radioprotector and mitigator of the hematopoietic syndrome induced by TBI...
  53. ncbi UV-induced NF-kappaB activation and expression of IL-6 is attenuated by (-)-epigallocatechin-3-gallate in cultured human keratinocytes in vitro
    Jiping Xia
    Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, PR China
    Int J Mol Med 16:943-50. 2005
    ..Our data suggest that EGCG be added to cosmetic or skin-care products for prevention from UV-induced skin photoaging if this activity can be further confirmed and no cytotoxicity is reported in human skin in vivo...
  54. ncbi Amifostine as radioprotective agent for the rectal mucosa during irradiation of pelvic tumors. A phase II randomized study using various toxicity scales and rectosigmoidoscopy
    John Kouvaris
    Radiology Radiotherapy Department, National Technical University of Athens, Greece
    Strahlenther Onkol 179:167-74. 2003
    ..To evaluate the cytoprotective effect of amifostine against radiation-induced acute toxicity to the rectal mucosa...
  55. pmc Conformational changes in chromatin structure induced by the radioprotective aminothiol, WR 1065
    A T Vaughan
    Division of Biological and Medical Research, Argonne National Laboratory, IL 60349
    Br J Cancer 60:893-6. 1989
    ..It is proposed that perturbation of replicon supercoiling affects the process of normal DNA synthesis and strand break rejoining, allowing a longer time for the accurate repair of DNA damage...
  56. ncbi Effects of (-)-epigallocatechin-3-gallate on expression of matrix metalloproteinase-1 and tissue inhibitor of metalloproteinase-1 in fibroblasts irradiated with ultraviolet A
    Xiu Zu Song
    Department of Dermatology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
    Chin Med J (Engl) 117:1838-41. 2004
    ..In this study, we investigated the protective mechanism of EGCG on human dermal fibroblasts damaged by ultraviolet A (UVA) in vitro...
  57. ncbi Combined treatment with cytoprotective agents and radiotherapy
    Piotr Winczura
    Department of Oncology and Radiotherapy, Medical University of Gdansk, Poland
    Cancer Treat Rev 36:268-75. 2010
    ..The use of erythropoetins in combination with radiotherapy should generally be discouraged, whereas the safe and effective application of other agents warrants further investigations...
  58. ncbi Radiation proctitis. Clinical and pathological manifestations, therapy and prophylaxis of acute and late injurious effects of radiation on the rectal mucosa
    F B Zimmermann
    Klinik und Poliklinik für Strahlentherapie und Radiologische Onkologie, Klinikum rechts der Isar der Technischen Universitat Munchen
    Strahlenther Onkol 174:85-9. 1998
    ..Often the rectum is the dose-limiting organ in curative radiation therapy of pelvic malignancies. It reacts with serous, mucoid, or more rarely bloody diarrhea...
  59. ncbi Randomized, placebo-controlled trial of combined pentoxifylline and tocopherol for regression of superficial radiation-induced fibrosis
    Sylvie Delanian
    service d oncologie radiothérapie, Hopital Saint Louis 1, Paris, France
    J Clin Oncol 21:2545-50. 2003
    ..The present double-blind, placebo-controlled, monocentric study was designed to assess the efficacy of this combination in treating RIF sequelae...
  60. ncbi The green tea polyphenol (-)-epigallocatechin gallate and green tea can protect human cellular DNA from ultraviolet and visible radiation-induced damage
    Nick Morley
    Cornwall Dermatology Research Project, Polgooth Ward, Royal Cornwall Hospital, Treliske, Truro, Cornwall TR1 3LJ, UK
    Photodermatol Photoimmunol Photomed 21:15-22. 2005
    ..This work was then extended to investigate whether drinking green tea could afford any UVR protection to human peripheral blood cells collected after tea ingestion...
  61. ncbi WR-2721 reduces intestinal toxicity from concurrent gemcitabine and radiation treatment
    T P Phan
    Department of Experimental Radiation Oncology, The University of Texas M.D. Anderson Cancer Center, Houston 77030-4095, USA
    Int J Pancreatol 29:19-23. 2001
    ..42. Therefore, in clinical treatment protocols using concurrent chemoradiation with gemcitabine, WR-2721 may have clinical utility in protecting against radiation-induced mucosal toxicity...
  62. ncbi Role of curcumin, a naturally occurring phenolic compound of turmeric in accelerating the repair of excision wound, in mice whole-body exposed to various doses of gamma-radiation
    Ganesh Chandra Jagetia
    Department of Radiobiology, Kasturba Medical College, Manipal, India
    J Surg Res 120:127-38. 2004
    ..This study demonstrates that curcumin pretreatment has a conducive effect on the irradiated wound and could be a substantial therapeutic strategy in initiating and supporting the cascade of tissue repair processes in irradiated wounds...
  63. ncbi Cytoprotective effects of amifostine in the treatment of childhood malignancies
    Nazan Cetingul
    Department of Pediatric Oncology, Ege University Faculty of Medicine, Izmir, Turkey
    Pediatr Blood Cancer 52:829-33. 2009
    ..Amifostine has rarely been used in the childhood cancers as a multisystemic protective agent for minimizing these side effects...
  64. ncbi Tissue-protective effects of fullerenol C60(OH)24 and amifostine in irradiated rats
    Sanja Trajkovic
    Military Medical Academy, Belgrade, Serbia and Montenegro
    Colloids Surf B Biointerfaces 58:39-43. 2007
    ..These results confirm satisfactory radioprotective efficacy of fullerenol and encourage further investigations as a potential radioprotector...
  65. ncbi Radioprotectants: current status and new directions
    David J Grdina
    Department of Radiation and Cellular Oncology, The University of Chicago, Chicago, Ill 60637, USA
    Oncology 63:2-10. 2002
    ..The objective of developing newer cytoprotective therapies is to improve the therapeutic ratio by reducing the acute and chronic toxicities associated with more intensive and more effective anticancer therapies...
  66. ncbi Protective effect of alpha-tocopherol in head and neck cancer radiation-induced mucositis: a double-blind randomized trial
    Paulo Renato Ferreira
    Department of Radiation Oncology, Hospital Sao Lucas da PUC, Pontificia Universidade Catolica do Rio Grande do Sul PUCRS, Av Ipiranga 6690, Porto Alegre, RS 90610 000, Brazil
    Head Neck 26:313-21. 2004
    ..the study was designed to test whether vitamin E (VE) provides oral mucosal protection in patients with irradiated cancers of the head and neck...
  67. ncbi Genistein stimulates hematopoiesis and increases survival in irradiated mice
    Yong Zhou
    Department of Nutrition and Food Hygiene, School of Preventive Medicine, The Third Military Medical University, China
    J Radiat Res 46:425-33. 2005
    ..These effects of genistein may have some therapeutic implications for radiation-induced injuries...
  68. ncbi Therapeutic and clinical applications of nitroxide compounds
    Benjamin P Soule
    Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA
    Antioxid Redox Signal 9:1731-43. 2007
    ..The therapeutic and research uses of nitroxides are reviewed here, with a focus on the progress from initial development to modern, state-of-the art trials...
  69. ncbi Bowman-Birk protease inhibitor activates DNA-dependent protein kinase and reduces formation of radiation-induced dicentric chromosomes
    K Dittmann
    Section of Radiobiology and Environmental Research, Department of Radiation Oncology University of Tübingen Röntgenweg 11 D 72076 Tübingen Germany
    Int J Radiat Biol 79:801-8. 2003
    ..To test a stimulatory effect of the radioprotector Bowman Birk protease inhibitor (BBI) upon DNA repair processes...
  70. ncbi Ionizing radiation-induced damage on developing cerebellar granule cells cultures can be prevented by an early amifostine post-treatment
    Laura Ruth Guelman
    1 Cátedra de Farmacología, Facultad de Medicina, UBA, Paraguay 2155, Piso 15, 1121 Buenos Aires, Argentina
    Int J Dev Neurosci 23:1-7. 2005
    ....
  71. ncbi Antitransforming growth factor-beta antibody 1D11 ameliorates normal tissue damage caused by high-dose radiation
    Mitchell S Anscher
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC, USA
    Int J Radiat Oncol Biol Phys 65:876-81. 2006
    ..The aim of this study was to determine whether a neutralizing transforming growth factor-beta (TGFbeta) antibody can prevent radiation (RT) induced lung injury...
  72. ncbi Identification of nitroxide radioprotectors
    S M Hahn
    Radiobiology Section, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892
    Radiat Res 132:87-93. 1992
    ..This study establishes nitroxides as a general class of new nonthiol radioprotectors and suggests other parameters that may be exploited to find even better nitroxide-induced radioprotection...
  73. ncbi Fullerenes as a new class of radioprotectors
    H S Lin
    Department of Radiology, Washington University Medical School, St Louis, Missouri 63110, USA
    Int J Radiat Biol 77:235-9. 2001
    ..To evaluate the radioprotective activity of C3, a regioisomer of water-soluble carboxyfullerene and a potent free radical scavenger, on both normal and tumour cells...
  74. ncbi Induction of marrow hypoxia by radioprotective agents
    M J Allalunis Turner
    Cross Cancer Institute, Edmonton, Alberta, Canada
    Radiat Res 118:581-6. 1989
    ..These results suggest that the physiological effects of some radioprotectors, that is, their ability to induce marrow hypoxia, may contribute to their efficacy in vivo...
  75. ncbi Oral candidiasis in head and neck cancer patients receiving radiotherapy with amifostine cytoprotection
    Ourania Nicolatou-Galitis
    Department of Oral Pathology and Surgery, School of Dentistry, University of Athens, Athens, Greece
    Oral Oncol 39:397-401. 2003
    ..Oral candidiasis was reduced with amifostine cytoprotection. Oral candidiasis is suggested as an objective, early, though indirect, endpoint for amifostine's radioprotective effect on salivary glands...
  76. ncbi The potential of amifostine: from cytoprotectant to therapeutic agent
    V Santini
    Dept of Hematology, Policlinico di Careggi, Viale Morgagni 85, 50134 Florence, Italy
    Haematologica 84:1035-42. 1999
    ....
  77. ncbi Radioprotective effect of Panax ginseng on the phosphatases and lipid peroxidation level in testes of Swiss albino mice
    Madhu Kumar
    Department of Zoology, University of Rajasthan, Jaipur, India
    Biol Pharm Bull 26:308-12. 2003
    ..Ginseng markedly inhibits lipid peroxidation. It acts in indirect fashion to protect radical processes by inhibition of initiation of free radical processes and thus reduces the radiation damages in testes of Swiss albino mice...
  78. ncbi Radiosensitization and DNA repair inhibition by pentoxifylline in NIH3T3 p53 transfectants
    A Binder
    Department of Radiation Oncology, Radiobiology Laboratory, University of Stellenbosch, Faculty of Health and Tygerberg Hospital, PO Box 19063, Tygerberg 7505, South Africa
    Int J Radiat Biol 78:991-1000. 2002
    ..To examine the role of p53 mutations in the modulation of DNA repair and radiotoxicity by pentoxifylline...
  79. ncbi Influence of irradiation and pentoxifylline on histone H3 phosphorylation in human tumour cell lines
    A Binder
    Department of Radiation Oncology, University of Stellenbosch, Faculty of Health Sciences and Tygerberg Hospital, Tygerberg, South Africa
    Cell Prolif 35:37-47. 2002
    ..This suggests that addition of pentoxifylline indeed abrogates the G2 block and thereby facilitates early entry into mitosis...
  80. ncbi Physiological mechanisms of radiation sensitization by pentoxifylline
    I Lee
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6072, USA
    Anticancer Res 20:4605-9. 2000
    ..However, we did not observe any alteration in cellular oxygen consumption (QO2) after the treatment with PTX. Therefore, we concluded that PTX-induced radiosensitization was due to an increase in tumor pO2, not a reduction in QO2...
  81. ncbi Evaluation and optimization of radioprotective activity of Coronopus didymus Linn. in gamma-irradiated mice
    K R Prabhakar
    Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal, India
    Int J Radiat Biol 82:525-36. 2006
    ..To correlate the free radical scavenging studies with in vivo radioprotection ability...
  82. ncbi Amelioration of early radiation effects in oral mucosa (mouse) by intravenous or subcutaneous administration of amifostine
    Gabriele Fleischer
    Department of Radiotherapy and Radiooncology, Medical Faculty Carl Gustav Carus, Technical University, Dresden, Germany
    Strahlenther Onkol 182:567-75. 2006
    ..To quantify the reduction of radiation-induced oral mucositis by amifostine as a function of administration route...
  83. ncbi Radioprotective potential of Rosemarinus officinalis against lethal effects of gamma radiation : a preliminary study
    Archana Jindal
    Radiation and Cancer Biology Laboratory, Department of Zoology, University of Rajasthan, Jaipur 302 004, India
    J Environ Pathol Toxicol Oncol 25:633-42. 2006
    ..The present study demonstrates that Rosemarinus officinalis leave extract is a good radioprotector...
  84. ncbi Kojic acid and its manganese and zinc complexes as potential radioprotective agents
    Saeed Emami
    Department of Medicinal Chemistry, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
    Bioorg Med Chem Lett 17:45-8. 2007
    ..The results of in vivo radioprotection showed that these compounds exhibited significant radioprotective effects against lethal dose of gamma-irradiation in mice...
  85. ncbi Radioprotection of Swiss albino mice by Myristica fragrans houtt
    Mini Sharma
    Cell and Molecular Biology Lab, Department of Zoology, University of Rajasthan, Jaipur, India
    J Radiat Res (Tokyo) 48:135-41. 2007
    ..The present study has implications for the potential use of MF as a radioprotector...
  86. ncbi Curcumin treatment enhances the repair and regeneration of wounds in mice exposed to hemibody gamma-irradiation
    Ganesh Chandra Jagetia
    Department of Radiobiology, Kasturba Medical College, Manipal, India
    Plast Reconstr Surg 115:515-28. 2005
    ....
  87. ncbi Radioprotection by mangiferin in DBAxC57BL mice: a preliminary study
    G C Jagetia
    Department of Radiobiology, Kasturba Medical College Manipal, Karnataka 576104, India
    Phytomedicine 12:209-15. 2005
    ..The administration of 400 mg/kg MGN induced 50% mortality, therefore LD50 of the drug was considered to be 400 mg/kg...
  88. ncbi Influence of seed extract of Syzygium Cumini (Jamun) on mice exposed to different doses of gamma-radiation
    Ganesh Chandra Jagetia
    Department of Radiobiology, Kasturba Medical College, Manipal India
    J Radiat Res 46:59-65. 2005
    ..The SCE treatment protected mice against the gastrointestinal as well as bone marrow deaths and the DRF was found to be 1.24...
  89. ncbi Protective effects of soybean isoflavone against gamma-irradiation induced damages in mice
    Li Hua Song
    Department of Food Science and Engineering, Shanghai Jiaotong University, Shanghai, China
    J Radiat Res 47:157-65. 2006
    ..Our results provide useful information for future investigations, and strongly implicate a clinical application for SI...
  90. ncbi Radioprotective influence of Mentha piperita (Linn) against gamma irradiation in mice: Antioxidant and radical scavenging activity
    Ravindra M Samarth
    Radiation and Cancer Biology Laboratory, Department of Zoology, University of Rajasthan, Jaipur, India
    Int J Radiat Biol 82:331-7. 2006
    ..To evaluate the radiomodulatory influence of a leaf extract of Mentha piperita (Linn) on hepatic antioxidant status and lipid peroxidation in Swiss albino mice...
  91. ncbi Protective effects of melatonin on gamma-ray induced intestinal damage
    Manami Monobe
    Department of Radiation Biosciences, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Noda shi, Chiba, Japan
    Int J Radiat Biol 81:855-60. 2005
    ..To examine the protective effects of melatonin on intestinal damage induced by gamma-rays...
  92. ncbi Feasibility and efficacy of subcutaneous amifostine therapy in patients with head and neck cancer treated with curative accelerated concomitant-boost radiation therapy
    Mahmut Ozsahin
    Department of Radiation Oncology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Arch Otolaryngol Head Neck Surg 132:141-5. 2006
    ..To assess the feasibility and efficacy of subcutaneous amifostine therapy in patients with head and neck cancer treated with curative accelerated radiotherapy (RT)...
  93. ncbi Head and neck squamous cell carcinoma: optimizing the therapeutic index
    David I Rosenthal
    Department of Radiation Oncology, 097, The University of Texas, MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030 4009, USA
    Expert Rev Anticancer Ther 5:501-14. 2005
    ..These strategies are reviewed in a clinical context...
  94. ncbi Oral oxymetholone reduces mortality induced by gamma irradiation in mice through stimulation of hematopoietic cells
    Seyed Jalal Hosseinimehr
    Department of Medicinal Chemistry, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
    Mol Cell Biochem 287:193-9. 2006
    ..These results demonstrate that oxymetholone stimulates myelopoiesis and thrombocytopenia and enhances survival in mice after ionizing radiation...
  95. ncbi Modulatory influence of Adhatoda vasica Nees leaf extract against gamma irradiation in Swiss albino mice
    A Kumar
    Radiation and Cancer Biology Laboratory, Department of Zoology, University of Rajasthan, Jaipur, India
    Phytomedicine 12:285-93. 2005
    ..A significant increase in the serum alkaline phosphatase activity and decrease in acid phosphatase activity was observed in A. vasica leaf extract pretreated irradiated animals during the entire period of study...
  96. ncbi Evaluation of the radioprotective effect of Liv 52 in mice
    Ganesh C Jagetia
    Department of Radiobiology, Kasturba Medical College, Manipal, Karnataka, India
    Environ Mol Mutagen 47:490-502. 2006
    ....
  97. ncbi Amifostine has an inhibitory effect on the radiation-induced p53-branched cascade in the immature mouse ovary
    Yong Dal Yoon
    Hanyang University, 17 Haengdang dong, Seongdong Gu, Seoul 133 791, Korea
    In Vivo 19:509-14. 2005
    ..In conclusion, amifostine had an inhibitory effect on ovarian programmed cell death induced by gamma-ray, affecting the expression of apoptotic signaling molecules and the level of proliferation of the granulosa cells...
  98. ncbi Guanosine and inosine as natural antioxidants and radioprotectors for mice exposed to lethal doses of gamma-radiation
    S V Gudkov
    Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow Oblast, 142290 Russia
    Dokl Biochem Biophys 407:47-50. 2006
  99. ncbi Radioprotective effects of various cytokines in peripheral blood mononuclear cells and C3H mice
    Ju Young Kim
    Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea
    Oncol Rep 13:1177-83. 2005
    ..These findings indicate that the combined treatment of IL-3 and SCF prevents the apoptosis induced in PBMCs by gamma-irradiation in vitro, but it does not afford any in vivo radioprotective effect in lethally irradiated C3H mice...
  100. ncbi Triphala, an ayurvedic rasayana drug, protects mice against radiation-induced lethality by free-radical scavenging
    Ganesh Chandra Jagetia
    Department of Radiobiology, Kasturba Medical College, Manipal 576 104, Karnataka, India
    J Altern Complement Med 10:971-8. 2004
    ..Triphala was found to scavenge (.)OH, O(2) (.) 2,2'-azinobis(3-ethylbenzthiazoline-6-sulfonate) diammonium salt (ABTS)(.+) and NO(.) radicals in a dose dependent manner...
  101. ncbi Modulation of chromatin organization by RH-3, a preparation of Hippophae rhamnoides, a possible role in radioprotection
    I Prem Kumar
    Department of Radiation Biology, Institute of Nuclear Medicine and Allied Sciences, INMAS, Delhi, India
    Mol Cell Biochem 238:1-9. 2002
    ..Further work to unravel these facts would be necessary...

Research Grants46

  1. THE ROLE OF PROTEIN PHOSPHATASE PP2A IN RADIATION INDUCED STEM CELL APOPTOSIS
    GIRDHAR GOPAL SHARMA; Fiscal Year: 2013
    ....
  2. Centers for Medical Countermeasures Against Radiation
    ALAN D ANDREA; Fiscal Year: 2009
    ..The program is designed to accelerate the development of new medical applications in the field of countermeasures against radiation. ..
  3. Improving Gastrointestinal Recovery after Radiation
    George Georges; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  4. Radioprotection by use of Topical Lithium Formulations
    Dennis Hallahan; Fiscal Year: 2009
    ..Inhibitors of GSK-32 pathway can serve as radiation protective agents. Lithium can inhibit the GSK-32 pathway...
  5. RADIOPROTECTIVE DRUGS--MECHANISM AND BIOLOGICAL STUDIES
    Janet Rasey; Fiscal Year: 1992
    ..Analytical techniques (HPLC, TLC, autoradiography) will be developed and used...
  6. GROWTH PLATE CELLULAR FUNCTION FOLLOWING RADIOTHERAPY
    Timothy Damron; Fiscal Year: 2008
    ..abstract_text> ..
  7. Mechanisms of Female Germline Stem Cell Senescence
    Jonathan Tilly; Fiscal Year: 2006
    ..abstract_text> ..
  8. Mechanisms of Aryl-Hydrocarbon-Induced Ovotoxicity
    Jonathan Tilly; Fiscal Year: 2005
    ....
  9. Lung Radiation Protection by MnSOD Transgene Therapy
    Joel Greenberger; Fiscal Year: 2005
    ..This project may facilitate development of specific strategies to minimize pulmonary irradiation toxicity, thereby making RT safer and more effective. ..
  10. Gene Therapy Reduction of Radiotherapy Esophagitis
    Joel S Greenberger; Fiscal Year: 2010
    ..These studies should elucidate the molecular mechanism of induction of damage to engrafting marrow origin, epithelial stem cells by the irradiated esophageal microenvironment and identify new targets for therapeutic intervention. ..
  11. MnSOD-PL Irradiation Protection of the Oral Cavity
    Joel Greenberger; Fiscal Year: 2008
    ..This project should validate the use of radioprotective gene therapy for improving the quality of life in head and neck cancer patients, and may also facilitate irradiation dose escalation by modulating side effects. ..
  12. Pre-clinical Trials for Female Fertility Preservation
    Jonathan Tilly; Fiscal Year: 2008
    ..abstract_text> ..
  13. APOPTOSIS AND REPRODUCTIVE AGING OF THE FEMALE
    Jonathan Tilly; Fiscal Year: 2003
    ..It is anticipated these data will provide the first unequivocal proof that exhaustion of the follicle reserve can be delayed, if not prevented, by manipulating apoptosis-regulatory genes. ..
  14. KIDNEY RESPONSE TO RADIATION AND CHEMOTHERAPY
    JOHN MOULDER; Fiscal Year: 2006
    ..unreadable] 4) Complete the randomized, prospective, trial of the use of ACE inhibitors to prevent the development of radiation nephropathy in BMT patients. [unreadable] [unreadable]..
  15. Mechanism of hypoxia mediated radiation lung injury
    Zeljko Vujaskovic; Fiscal Year: 2006
    ..abstract_text> ..
  16. ONTOGENY AND DEVELOPMENT OF HEMATOPOIETIC STEM CELLS
    William Fleming; Fiscal Year: 2004
    ..The relative dominance of each will then be assessed. Then, the role of the immune system and the effects it mediates on transplanted hematopoietic stem cells will be examined. ..
  17. SERTOLI CELL TOXICITY IN VIVO--MICROTUBULE DISRUPTION
    Kim Boekelheide; Fiscal Year: 2001
    ..Together, these complimentary approaches will critically examine key steps in the pathogenetic sequence by which microtubule disrupters alter the supportive capacity of Sertoli cells resulting in loss of germ cells and infertility. ..
  18. Polyamine Suppression By Antizyme inducing Analogs
    John Mitchell; Fiscal Year: 2002
    ..These studies will provide an essential foundation for further exploration of the chemical induction of antizyme as a means of chemoprevention in animals. ..
  19. Endothelial Potential of Bone Marrow Derived Progenitors
    William Fleming; Fiscal Year: 2008
    ..These studies will identify bone marrow derived endothelial progenitors that in the future may be targeted to enhance vascular repair and to attenuate the progression of vascular disease. ..
  20. BAEP SCREENING OF NEONATES
    MICHAEL CHURCH; Fiscal Year: 2001
    ..This proposal will address these issues as well. Potentially confounding variables will be gathered and their influence assessed and statistically controlled. Appropriate clinical interventions for mother and infant will be made. ..
  21. Rescue of radiation-induced salivary gland dysfunction by Akt
    KIRSTEN LIMESAND; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  22. Automation of Head and Neck Radiation Treatment Planning
    Julian Rosenman; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  23. Diagnostic Therapeutic Targets in Prostate Cancer
    Andrei Gudkov; Fiscal Year: 2007
    ....
  24. A New Antioxidant Prevents Toxicity of HIV Proteins with Methamphetamine
    Nuran Ercal; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  25. Feedback and Hormonal Regulation of Hepatic HMG-CoA Reductase
    GENE CHARLES NESS; Fiscal Year: 2010
    ....
  26. MESNA METABOLISM AND DISPOSITION
    MARSHALL GOREN; Fiscal Year: 2001
    ..These studies also will position us to test the effect of complex combinatorial therapies on cardiac and multi-organ toxicity. ..
  27. INDUCTION OF GENOMIC INSTABILITY IN HUMAN LYMPHOBLASTS
    Helen Evans; Fiscal Year: 2001
    ..Knowledge of the target for the induction of instability and the nature of that instability is important for the development of better predictive models of risk and appropriate radiation protection measures. ..
  28. PHTHALATE-INDUCED MURINE TESTICULAR DYSGENESIS AND P53
    Kim Boekelheide; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  29. Phase I Clinical Trials of Anti-Cancer Agents
    Francis Giles; Fiscal Year: 2007
    ..abstract_text> ..
  30. Suppression of Salivary Gland Apoptosis by AKt
    KIRSTEN LIMESAND; Fiscal Year: 2003
    ..These studies will provide greater insight to the understanding of this tissue and potentially provide clinical treatment of cancer-induced apoptosis in salivary glands. ..
  31. ENVIRONMENTAL/INDUSTRIAL TOXICANTS AND TESTICULAR INJURY
    Kim Boekelheide; Fiscal Year: 2003
    ..Together, these complimentary approaches will elucidate the key molecular mechanisms responsible for irreversible testicular injury. ..
  32. EXPERIMENTAL RADIOTHERAPY--CARCINOGENESIS, AND PROTECTOR
    DAVID GRDINA; Fiscal Year: 2003
    ..abstract_text> ..
  33. ISSA: novel functional approach to cancer-related genes
    Andrei Gudkov; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  34. Protecting immune system by modulators of p53 and NF-kB
    Andrei Gudkov; Fiscal Year: 2005
    ..abstract_text> ..
  35. RADIODIAGNOSIS & RADIOTHERAPY OF LUNG CANCER METASTASES
    AMIN KASSIS; Fiscal Year: 2004
    ....
  36. Study of Intrinsic Bladder Activity by Optical Imaging
    Anthony Kanai; Fiscal Year: 2007
    ..To study the neural-chemical control of spontaneous detrusor activity; and III.) To determine the origin of detrusor overactivity in partially obstructed bladders. ..
  37. STRESS INDUCED BYSTANDER EFFECT IN CANCER TREATMENT
    Andrei Gudkov; Fiscal Year: 2004
    ..abstract_text> ..
  38. P28-DRA IN THE STRESS RESPONSE OF MAMMALIAN CELLS
    Michael Story; Fiscal Year: 2001
    ..Understanding how p28dra functions will provide new insights into overcoming resistance to cancer therapy and possibly lead to new clinical strategies in cancer management. ..
  39. Delayed Radioprotection by Thiols
    DAVID GRDINA; Fiscal Year: 2006
    ..Two, elevation in MnSOD level without a concomitant increase in enzymatic activity can result from nitration of MnSOD by peroxynitrite (ONOO-). ..
  40. Targeted Alpha-Particle Emitter Therapy of Metastases
    George Sgouros; Fiscal Year: 2009
    ..The work described in this application is intended to develop and evaluate such an approach. ..
  41. Radioprotective Potential of Ginseng
    Tung Kwang Lee; Fiscal Year: 2006
    ..Accomplishing these aims will provide an essential prerequisite to the development of NAGE as an effective radioprotector. ..
  42. Hospice Pain Control: Developing an Opioid Order Sheet
    Barbara Murphy; Fiscal Year: 2006
    ..Once the modifications lave been made, we will conduct a pilot study to assess feasibility, utility and efficacy of the order sheet in the outpatient hospice setting. [unreadable] [unreadable]..
  43. HGF Signaling in Pulmonary Remodeling
    Regina Day; Fiscal Year: 2007
    ..In addition, it is expected that the results will fundamentally advance the field of lung cell biology. ..
  44. MODELING AND DOSIMETRY FOR RADIOLABELED ANTIBODY THERAPY
    George Sgouros; Fiscal Year: 2002
    ....