antidotes

Summary

Summary: Agents counteracting or neutralizing the action of POISONS.

Top Publications

  1. ncbi Identification of a mechanism by which the methylmercury antidotes N-acetylcysteine and dimercaptopropanesulfonate enhance urinary metal excretion: transport by the renal organic anion transporter-1
    Albert S Koh
    Department of Environmental Medicine, University of Rochester School of Medicine, Rochester, NY 14642, USA
    Mol Pharmacol 62:921-6. 2002
  2. pmc A cost effectiveness analysis of the preferred antidotes for acute paracetamol poisoning patients in Sri Lanka
    S M D K Ganga Senarathna
    Department of Pharmacology, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka
    BMC Clin Pharmacol 12:6. 2012
  3. ncbi New developments in antidotes
    Nicole L Ries
    Rocky Mountain Poison and Drug Center, Denver Health, Denver, CO 80204, USA
    Med Clin North Am 89:1379-97. 2005
  4. ncbi Availability of antidotes in hospital pharmacies in Greece
    M Plataki
    Laboratory of Clinical Pharmacology and of Toxicology, Medical School, University of Crete, Greece
    Vet Hum Toxicol 43:103-5. 2001
  5. ncbi Indications for single-dose activated charcoal administration in acute overdose
    Geoffrey K Isbister
    Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle and Discipline of Clinical Pharmacology, University of Newcastle, New South Wales, Australia
    Curr Opin Crit Care 17:351-7. 2011
  6. ncbi Inadequate stocking of antidotes in Taiwan: is it a serious problem?
    H C Ong
    Department of Internal Medicine, Veterans General Hospital Taipei, National Yang Ming University, Taiwan, Republic of China
    J Toxicol Clin Toxicol 38:21-8. 2000
  7. ncbi Expert consensus guidelines for stocking of antidotes in hospitals that provide emergency care
    Richard C Dart
    Rocky Mountain Poison and Drug Center Denver Health, Denver, CO, USA
    Ann Emerg Med 54:386-394.e1. 2009
  8. ncbi RNA aptamers as reversible antagonists of coagulation factor IXa
    Christopher P Rusconi
    Department of Surgery, Program in Combinatorial Therapeutics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nature 419:90-4. 2002
  9. pmc Availability of antidotes at acute care hospitals in Ontario
    D N Juurlink
    Department of Medicine, University of Toronto, Canada
    CMAJ 165:27-30. 2001
  10. ncbi Neuroparalysis and oxime efficacy in organophosphate poisoning: a study of butyrylcholinesterase
    S Khan
    Department of Medicine, Christian Medical College and Hospital, Vellore, Tamil Nadu, India
    Hum Exp Toxicol 20:169-74. 2001

Detail Information

Publications282 found, 100 shown here

  1. ncbi Identification of a mechanism by which the methylmercury antidotes N-acetylcysteine and dimercaptopropanesulfonate enhance urinary metal excretion: transport by the renal organic anion transporter-1
    Albert S Koh
    Department of Environmental Medicine, University of Rochester School of Medicine, Rochester, NY 14642, USA
    Mol Pharmacol 62:921-6. 2002
    ..These results indicate that the MeHg antidotes NAC and DMPS and their mercaptide complexes are transported by Oat1 but are comparatively poor substrates for ..
  2. pmc A cost effectiveness analysis of the preferred antidotes for acute paracetamol poisoning patients in Sri Lanka
    S M D K Ganga Senarathna
    Department of Pharmacology, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka
    BMC Clin Pharmacol 12:6. 2012
    Acute paracetamol poisoning is a rapidly increasing problem in Sri Lanka. The antidotes are expensive and yet no health economic evaluation has been done on the therapy for acute paracetamol poisoning in the developing world...
  3. ncbi New developments in antidotes
    Nicole L Ries
    Rocky Mountain Poison and Drug Center, Denver Health, Denver, CO 80204, USA
    Med Clin North Am 89:1379-97. 2005
    Although some antidotes are rarely used, they have an important, potentially life-saving role in the treatment of toxic exposures...
  4. ncbi Availability of antidotes in hospital pharmacies in Greece
    M Plataki
    Laboratory of Clinical Pharmacology and of Toxicology, Medical School, University of Crete, Greece
    Vet Hum Toxicol 43:103-5. 2001
    We determined the availability of poisoning antidotes in the pharmacies of state hospitals in Greece and in Health Centers of the island of Crete...
  5. ncbi Indications for single-dose activated charcoal administration in acute overdose
    Geoffrey K Isbister
    Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle and Discipline of Clinical Pharmacology, University of Newcastle, New South Wales, Australia
    Curr Opin Crit Care 17:351-7. 2011
    ..There has been a significant decrease in the use of single-dose activated charcoal (SDAC) in recent years based on little new evidence and possibly because the overall mortality in overdose patients is low...
  6. ncbi Inadequate stocking of antidotes in Taiwan: is it a serious problem?
    H C Ong
    Department of Internal Medicine, Veterans General Hospital Taipei, National Yang Ming University, Taiwan, Republic of China
    J Toxicol Clin Toxicol 38:21-8. 2000
    Insufficient hospital stock of a variety of poisoning antidotes is a worldwide problem...
  7. ncbi Expert consensus guidelines for stocking of antidotes in hospitals that provide emergency care
    Richard C Dart
    Rocky Mountain Poison and Drug Center Denver Health, Denver, CO, USA
    Ann Emerg Med 54:386-394.e1. 2009
    ..We developed recommendations for antidote stocking at hospitals that provide emergency care...
  8. ncbi RNA aptamers as reversible antagonists of coagulation factor IXa
    Christopher P Rusconi
    Department of Surgery, Program in Combinatorial Therapeutics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nature 419:90-4. 2002
    ..We also show that oligonucleotides complementary to these aptamers can act as antidotes capable of efficiently reversing the activity of these new anticoagulants in plasma from healthy volunteers and ..
  9. pmc Availability of antidotes at acute care hospitals in Ontario
    D N Juurlink
    Department of Medicine, University of Toronto, Canada
    CMAJ 165:27-30. 2001
    Acutely poisoned patients sometimes require immediate treatment with an antidote, and delays in treatment can be fatal. We sought to determine the availability of 10 antidotes at acute care hospitals in Ontario.
  10. ncbi Neuroparalysis and oxime efficacy in organophosphate poisoning: a study of butyrylcholinesterase
    S Khan
    Department of Medicine, Christian Medical College and Hospital, Vellore, Tamil Nadu, India
    Hum Exp Toxicol 20:169-74. 2001
    ....
  11. pmc Biomimetic enzyme nanocomplexes and their use as antidotes and preventive measures for alcohol intoxication
    Yang Liu
    Key Laboratory of Functional Polymer Materials, Ministry of Education, and Institute of Polymer Chemistry, Nankai University, Tianjin 300071, China
    Nat Nanotechnol 8:187-92. 2013
    ..We show that nanocomplexes containing alcohol oxidase and catalase could reduce blood alcohol levels in intoxicated mice, offering an alternative antidote and prophylactic for alcohol intoxication...
  12. ncbi [Availability of antidotes in Denmark]
    Peter Jacobsen
    H S Bispebjerg Hospital, Arbejds og miljømedicinsk Klinik, giftinformationen, København
    Ugeskr Laeger 166:4257-60. 2004
  13. ncbi Antidotes and their availability in South Africa
    Cherylynn Angela Wium
    Department Pharmacology, Tygerberg Poison Information Centre, Cape Town, South Africa
    Clin Toxicol (Phila) 47:77-80. 2009
    The availability of antidotes is essential and often lifesaving in management of certain poisonings. Surveys conducted in a number of countries have demonstrated inadequate availability of antidotes...
  14. ncbi Response of arsenic-induced oxidative stress, DNA damage, and metal imbalance to combined administration of DMSA and monoisoamyl-DMSA during chronic arsenic poisoning in rats
    S Bhadauria
    Defence Research and Development Establishment, Gwalior, India
    Cell Biol Toxicol 23:91-104. 2007
    ..This combination was also able to repair DNA damage caused following arsenic exposure. We thus recommend combined administration of DMSA and MiADMSA for achieving optimum effects of chelation therapy...
  15. ncbi Do antidotes for acute cyanide poisoning act on mercaptopyruvate sulfurtransferase to facilitate detoxification?
    Noriyuki Nagahara
    Department of Environmental Medicine, Nippon Medical School, Tokyo, Japan
    Curr Drug Targets Immune Endocr Metabol Disord 3:198-204. 2003
    ....
  16. ncbi [Availability of antidotes in hospital pharmacies in the Czech Republic]
    K Hruby
    Nemocnicní lékárna pri VNMBA, Ostrava Vitkovice
    Ceska Slov Farm 52:231-40. 2003
    Availability of antidotes in the Czech Republic (CR) is insufficient. Many antidotes are not approved in CR, so their obtaining is problematic...
  17. ncbi The use of serial measurement of plasma cholinesterase in the management of acute poisoning with organophosphates and carbamates
    I M Abdullat
    Toxicology Laboratory, National Drug and Poison Information Center, Jordan University Hospital, The University of Jordan, Jordan
    Forensic Sci Int 162:126-30. 2006
    ..To evaluate the benefits of using serial measurements of plasma cholinesterase (butyrylcholinesterase, BuChE) activity in the management of cholinesterase inhibitor insecticidal poisoning...
  18. pmc Development of universal antidotes to control aptamer activity
    Sabah Oney
    Duke Translational Research Institute, Duke University Medical Center, Department of Surgery, University Program in Genetics and Genomics, Duke University, Durham, North Carolina, USA
    Nat Med 15:1224-8. 2009
    ..acute side effects of drugs, but, unfortunately, it has been challenging and cost prohibitive to generate antidotes for most therapeutic agents...
  19. ncbi Availability of antidotes for the treatment of acute poisoning in Queensland public hospitals
    Lisa M Nissen
    University of Queensland, Brisbane, Australia
    Aust J Rural Health 18:78-84. 2010
    To determine the sufficiency of stock levels of 13 antidotes in Queensland hospitals.
  20. ncbi Acute neurotoxicity in children with B-precursor acute lymphoid leukemia: an association with intermediate-dose intravenous methotrexate and intrathecal triple therapy--a Pediatric Oncology Group study
    D H Mahoney
    Texas Children s Cancer Center, Baylor College of Medicine, Houston, USA
    J Clin Oncol 16:1712-22. 1998
    ..v.) mercaptopurine (MP) and extended intrathecal triple therapy...
  21. pmc Sulfur mustard analog, 2-chloroethyl ethyl sulfide-induced skin injury involves DNA damage and induction of inflammatory mediators, in part via oxidative stress, in SKH-1 hairless mouse skin
    Anil K Jain
    Department of Pharmaceutical Sciences, University of Colorado Denver School of Pharmacy, Aurora, CO 80045, USA
    Toxicol Lett 205:293-301. 2011
    ..This study could help in identifying countermeasures that alone or in combination, can target the unveiled pathways for reducing skin injury in humans by SM...
  22. ncbi Evaluate the impact of hospital types on the availability of antidotes for the management of acute toxic exposures and poisonings in Malaysia
    Sulaiman I Al-Sohaim
    WHO Collaborating Centre for Drug Information, National Poison Centre, Universiti Sains Malaysia USM, Penang, Malaysia
    Hum Exp Toxicol 31:274-81. 2012
    The availability of antidotes may be considered essential and lifesaving in the management of certain poisonings. Surveys carried out in a number of countries have demonstrated inadequate availability of a variety of poisoning antidotes.
  23. ncbi Access in New Zealand to antidotes for accidental and intentional drug poisonings
    Victoria Abbott
    School of Pharmacy, University of Otago, Dunedin, New Zealand
    J Prim Health Care 4:100-5. 2012
    Access to antidotes for the treatment of drug poisonings can impact on morbidity and mortality...
  24. ncbi Antidotes for toxicological emergencies: a practical review
    Jeanna M Marraffa
    Upstate New York Poison Center, 750 East Adams Street, Syracuse, NY 13210, USA
    Am J Health Syst Pharm 69:199-212. 2012
    ..Appropriate therapies for commonly encountered poisonings, medication overdoses, and other toxicological emergencies are reviewed, with discussion of pharmacists' role in ensuring their ready availability and proper use...
  25. ncbi Antidotes for acute cyanide poisoning
    Stephen W Borron
    Texas Tech University Health Sciences Center at EI Paso, Paul L Foster School of Medicine, USA
    Curr Pharm Biotechnol 13:1940-8. 2012
    ..Multiple antidotes exist and vary in regional availability. All currently marketed antidotes appear to be effective...
  26. ncbi Evaluation of antidotes: activities of the International Programme on Chemical Safety
    J Pronczuk de Garbino
    IPCS WHO, Geneva, Switzerland
    J Toxicol Clin Toxicol 35:333-43. 1997
    Important developments concerning the role of antidotes in managing poisoning cases have taken place in recent decades due to new toxicodynamic and toxicokinetic studies and to growing international concern regarding the effectiveness of ..
  27. ncbi A dosing regimen for immediate N-acetylcysteine treatment for acute paracetamol overdose
    Finna Shen
    School of Pharmacy, University of Otago, Dunedin, New Zealand
    Clin Toxicol (Phila) 49:643-7. 2011
    ..This may result in dosing errors, a delay in treatment, or possibly more adverse effects - due to the use of a high dose rate for the first infusion when treatment is initiated...
  28. ncbi Multifunctional drugs as novel antidotes for organophosphates' poisoning
    Ben Avi Weissman
    Casali Institute of Applied Chemistry, Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
    Toxicology 290:149-55. 2011
    ..are able to modulate σ(1) sites and/or GABAergic transmission seem to represent the emerging backbone for novel antidotes against OP poisoning. Several multifunctional drugs are already used for complex diseases e.g...
  29. ncbi A cell-based assay for screening of antidotes to, and antivenom against Chironex fleckeri (box jellyfish) venom
    Nicki Konstantakopoulos
    Department of Pharmacology, Monash University, Victoria, 3800 Australia
    J Pharmacol Toxicol Methods 59:166-70. 2009
    ..fleckeri venom on the proliferation of a rat aortic smooth muscle cell line. In addition, the ability of CSL box jellyfish antivenom and/or various potential treatment strategies to neutralise the effects of the venom was examined...
  30. ncbi Antidotes for nerve agent poisoning: should we differentiate children from adults?
    Mark D Baker
    Division of Pediatric Emergency Medicine, Department of Pediatrics, University of Alabama Birmingham, Birmingham, Alabama, USA
    Curr Opin Pediatr 19:211-5. 2007
    Chemical terrorism presents a threat to the civilian population, including children. Nerve agent antidotes are available in prepackaged autoinjectors that can be delivered rapidly following an exposure...
  31. ncbi Should a benzodiazepine antagonist be used in unconscious patients presenting to the emergency department?
    Adeline Su Yin Ngo
    Department of Emergency Medicine, Singapore General Hospital, Outram Road, Singapore 169608, Singapore
    Resuscitation 74:27-37. 2007
    ..No systemic review of this literature has been done on this topic...
  32. pmc Antidotes to anthrax lethal factor intoxication. Part 1: Discovery of potent lethal factor inhibitors with in vivo efficacy
    Guan Sheng Jiao
    PanThera Biopharma, LLC, Aiea, HI 96701, USA
    Bioorg Med Chem Lett 20:6850-3. 2010
    ..Sub-nanomolar small molecule inhibitors of anthrax lethal factor have been identified using SAR and Merck L915 (4) as a model compound. One of these compounds (16) provided 100% protection in a rat lethal toxin model of anthrax disease...
  33. ncbi Mechanism of organophosphates (nerve gases and pesticides) and antidotes: electron transfer and oxidative stress
    Peter Kovacic
    Department of Chemistry, San Diego State University, San Diego, CA 92182 0130, USA
    Curr Med Chem 10:2705-9. 2003
    ..Alkylation of DNA takes place which may lead to generation of reactive oxygen species. Structure-activity relationships are examined, including reduction potentials and the captodative effect...
  34. ncbi Mitigating effects of some antidotes on fluoride and arsenic induced free radical toxicity in mice ovary
    Devendra D Jhala
    Reproductive Endocrinology and Genotoxicology Unit, Department of Zoology, University School of Science, Gujarat University, Ahmedabad, India
    Food Chem Toxicol 46:1138-42. 2008
    ..001) by treatment with vitamin C, calcium, or vitamin E alone and in combination. Hence the induced toxicity was transient and reversible...
  35. ncbi Availability of antidotes in Quebec hospitals before and after dissemination of guidelines
    Benoit Bailey
    Divisions of Emergency Medicine and Clinical Pharmacology and Toxicology, Department of Pediatrics, St Justine Hospital, University of Montreal UM, Montreal, Canada
    Am J Health Syst Pharm 60:2345-9. 2003
  36. pmc Management of acute paracetamol poisoning in a tertiary care hospital
    S M D K G Senarathna
    Department of Pharmacology, Faculty of Medicine, University of Colombo, Sri Lanka
    Ceylon Med J 53:89-92. 2008
    ..To compare the management of acute paracetamol poisoning with the best evidence available, and to determine the effect of plasma paracetamol level estimation on the management...
  37. ncbi Flumazenil--treatment or toxin
    Donna L Seger
    Vanderbilt University Medical Center, Nashville, Tennessee 37212, USA
    J Toxicol Clin Toxicol 42:209-16. 2004
    ..Seizures may increase morbidity and mortality of the overdose. Benefit:Risk ratio of administering flumazenil should be determined in each overdose patient. Indications for flumazenil are limited...
  38. pmc Management of acute organophosphorus pesticide poisoning
    Darren M Roberts
    South Asian Clinical Toxicology Research Collaboration, Australian National University
    BMJ 334:629-34. 2007
  39. pmc Pralidoxime in acute organophosphorus insecticide poisoning--a randomised controlled trial
    Michael Eddleston
    Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, United Kingdom
    PLoS Med 6:e1000104. 2009
    ..Although the World Health Organization recommends use of pralidoxime, this antidote's effectiveness remains unclear. We aimed to determine whether the addition of pralidoxime chloride to atropine and supportive care offers benefit...
  40. ncbi Future applications of phosphotriesterases in the prophylaxis and treatment of organophosporus insecticide and nerve agent poisonings
    Miguel A Sogorb
    Division de Toxicologia, Instituto de Bioingenieria, Universidad Miguel Hernandez, Avenida de la Universidad s n, 03202 Elche, Spain
    Toxicol Lett 151:219-33. 2004
    ..Experimental data suggest that might be time to initiate clinical trials in order to study the efficacy of phosphotriesterases in the therapy and prophylaxis of OP intoxication...
  41. pmc Prolonged treatment with N-acetylcystine delays liver recovery from acetaminophen hepatotoxicity
    Runkuan Yang
    Department of Critical Care Medicine, University of Pittsburgh Medical School, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Crit Care 13:R55. 2009
    ..Therefore, we hypothesize that prolonged treatment with NAC impairs liver regeneration in ALI induced by APAP...
  42. ncbi In vitro and in vivo comparison of sulfur donors as antidotes to acute cyanide intoxication
    S I Baskin
    Pharmacology Division, US Army Medical Research Institute of Chemical Defence, Aberdeen Proving Ground, MD, USA
    J Appl Toxicol 19:173-83. 1999
    b>Antidotes for cyanide (CN) intoxication include the use of sulfane sulfur donors (SSDs), such as thiosulfate, which increase the conversion of CN to thiocyanate by the enzyme rhodanese...
  43. ncbi Hydroxocobalamin for poisoning caused by ingestion of potassium cyanide: a case study
    Jean Luc Fortin
    SAMU 25, CHU J Minjoz, Besancon, France
    J Emerg Med 39:320-4. 2010
    ..The case supports the efficacy of hydroxocobalamin for acute cyanide poisoning caused by ingestion of a cyanide salt. No adverse events attributed to hydroxocobalamin were observed...
  44. ncbi Which cyanide antidote?
    Alan H Hall
    Toxicology Consulting and Medical Translating Services, Inc, Laramie, WY 82072, USA
    Crit Rev Toxicol 39:541-52. 2009
    Cyanide has several antidotes, with differing mechanisms of action and diverse toxicological, clinical, and risk-benefit profiles...
  45. ncbi Are there teratogenic risks associated with antidotes used in the acute management of poisoned pregnant women?
    Benoit Bailey
    Division of Emergency Medicine, Department of Pediatrics, Hopital Ste Justine, Universite de Montreal, Montreal, Quebec, Canada
    Birth Defects Res A Clin Mol Teratol 67:133-40. 2003
    We reviewed evidence suggesting teratogenic risk associated with the use of antidotes in the acute management of poisoned pregnant women.
  46. ncbi Household chemicals: management of intoxication and antidotes
    Christine Rauber-Lüthy
    Swiss Toxicological Information Centre, Zurich, Switzerland
    EXS 100:339-63. 2010
    ..Button batteries normally pass the gastrointestinal tract without problems even in toddlers; in rare cases, however, they get lodged in the esophagus with the risk of localized tissue damage and esophageal perforation...
  47. ncbi Drugs and pharmaceuticals: management of intoxication and antidotes
    Silas W Smith
    New York City Poison Control Center, New York University School of Medicine, New York, USA
    EXS 100:397-460. 2010
    ..and inconsistent diagnostic and therapeutic infrastructure support, coupled with relatively few definitive antidotes, may complicate evaluation and management...
  48. ncbi Efficacy of hydroxocobalamin for the treatment of acute cyanide poisoning in adult beagle dogs
    Stephen W Borron
    University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    Clin Toxicol (Phila) 44:5-15. 2006
    ..The efficacy of hydroxocobalamin for acute cyanide poisoning was compared with that of saline vehicle in dogs...
  49. ncbi Acute poisonings treated in hospitals in Oslo: a one-year prospective study (II): clinical outcome
    Fridtjof Heyerdahl
    Department of Acute Medicine, Ullevaal University Hospital, Oslo, Norway
    Clin Toxicol (Phila) 46:42-9. 2008
    ..The changing pattern of acute poisoning may affect complications and outcome in these patients. An update study on acute poisonings was therefore performed and compared to similar data from 1980...
  50. ncbi In vitro evaluation of acetylcholinesterase reactivators as potential antidotes against tabun nerve agent poisonings
    Kamil Kuca
    Department of Toxicology, Faculty of Military Health Sciences, Hradec Kralove, Czech Republic
    Drug Chem Toxicol 29:443-9. 2006
    ..In most cases, the reactivation bell-shaped curve is obtained. The most potent AChE reactivators are selected and provided for further experiments during our development process...
  51. ncbi Prehospital administration of hydroxocobalamin for smoke inhalation-associated cyanide poisoning: 8 years of experience in the Paris Fire Brigade
    Jean Luc Fortin
    Emergency Department, Military Hospital Legouest, Metz, France
    Clin Toxicol (Phila) 44:37-44. 2006
    ..This article reports the results of a retrospective study of 8 years of experience of the Paris Fire Brigade with the prehospital use of hydroxocobalamin...
  52. ncbi Heavy metal poisoning: management of intoxication and antidotes
    Daniel E Rusyniak
    Department of Emergency Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    EXS 100:365-96. 2010
    ..For some metals there are no physiological concentrations that are beneficial; as such these metals only have the potential to cause toxicity. This chapter focuses on four of these: arsenic, mercury, lead and thallium...
  53. ncbi Cyanide poisoning and its treatment
    Rebeca Gracia
    North Texas Poison Center, Dallas, Texas 75235, USA
    Pharmacotherapy 24:1358-65. 2004
    ..Future research aims to find a faster-acting, more effective, and better tolerated treatment for cyanide toxicity...
  54. ncbi Application of recombinant DNA methods for production of cholinesterases as organophosphate antidotes and detectors
    Palmer Taylor
    Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093 0657, USA
    Arh Hig Rada Toksikol 58:339-45. 2007
    To develop new avenues for synthesizing novel antidotes for organophosphate poisoning and for detection of the organophosphates, we have turned to recombinant DNA methods to synthesize cholinesterases with unusual properties...
  55. pmc Overcoming apathy in research on organophosphate poisoning
    Nick A Buckley
    South Asian Clinical Toxicology Research Collaboration, Department of Clinical Pharmacology and Toxicology, Canberra Hospital, PO Box 11, Woden, ACT 2606, Australia
    BMJ 329:1231-3. 2004
  56. ncbi Current recommendations for treatment of severe toxic alcohol poisonings
    Bruno Megarbane
    Réanimation Médicale et Toxicologique, Hopital Lariboisiere, 2 rue Ambroise Pare, 5010 Paris, France
    Intensive Care Med 31:189-95. 2005
    ..S. trials definitively established its efficacy. Fomepizole appears safer than ethanol and while no comparative study of efficacy exists, fomepizole is recommended as the first-line antidote...
  57. pmc The need for translational research on antidotes for pesticide poisoning
    Nick A Buckley
    South Asian Clinical Toxicology Research Collaboration, Department of Clinical Medicine, University of Colombo, Colombo
    Clin Exp Pharmacol Physiol 32:999-1005. 2005
    ..few proven or effective treatments; in addition, very little clinical research has been performed to transfer antidotes shown to work in animal studies into clinical practice. 3...
  58. ncbi Novel S-substituted aminoalkylamino ethanethiols as potential antidotes against sulfur mustard toxicity
    Uma Pathak
    Defence Research and Development Establishment, Jhansi Road, Gwalior 474 002, India
    J Med Chem 47:3817-22. 2004
    ..where R = alky, alicyclic, aryl, and heterocyclic substituents, have been designed and synthesized as candidate antidotes against SM toxicity...
  59. pmc Pesticide poisoning in south India: opportunities for prevention and improved medical management
    Ch Srinivas Rao
    University College of Pharmaceutical Sciences, Kakatiya University, Warangal, India
    Trop Med Int Health 10:581-8. 2005
    ..We aimed to describe their frequency and distribution, and to assess quality of management and subsequent outcomes from pesticide poisoning in one large hospital in the district...
  60. ncbi Cyanides
    Anthony P Morocco
    Guam Memorial Hospital, Department of Emergency Medicine, 850 Gov Carlos Camacho Road, Oka, Tamuning, Guam
    Crit Care Clin 21:691-705, vi. 2005
    ..Treatment for significant poisonings includes aggressive supportive care and administration of antidotes such as sodium nitrite, sodium thiosulfate, and hydroxocobalamin...
  61. ncbi Biochemical and clinical profile after organophosphorus poisoning--a placebo-controlled trial using pralidoxime
    M A Cherian
    Dept of Biochemistry, Christian Medical College Hospital, Vellore 632 004, Tamil Nadu, India
    J Assoc Physicians India 53:427-31. 2005
    ..Organophosphorus (OP) compounds are the most common suicidal poison in developing countries and mortality continues to be high...
  62. ncbi Increased morbidity and mortality in acute human organophosphate-poisoned patients treated by oximes: a meta-analysis of clinical trials
    Roja Rahimi
    Department of Toxicology and Pharmacology, Faculty of Pharmacy, and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran
    Hum Exp Toxicol 25:157-62. 2006
    ..57 (95% CI 1.11-2.11). It can be concluded that oximes are not effective in the management of organophosphate-poisoned patients and, surprisingly, they can be dangerous and worsen the patient's clinical situation...
  63. ncbi Hydroxocobalamin as a cyanide antidote
    Carol Ann DesLauriers
    Illinois Poison Center, Chicago, Illinois 60606, USA
    Am J Ther 13:161-5. 2006
  64. ncbi Metabolic acidosis: differentiating the causes in the poisoned patient
    Bryan S Judge
    DeVos Children s Hospital Regional Poison Center, Grand Rapids, MI 49503, USA
    Med Clin North Am 89:1107-24. 2005
    ..When confronted with such a patient, it is imperative that one administer appropriate antidotal therapy, when necessary, and provide the patient with exceptional supportive care...
  65. ncbi Adverse drug events associated with the antidotes for methanol and ethylene glycol poisoning: a comparison of ethanol and fomepizole
    Katherine J Lepik
    British Columbia Drug and Poison Information Centre, Vancouver, British Columbia, Canada
    Ann Emerg Med 53:439-450.e10. 2009
    We investigate adverse drug events associated with antidotes ethanol and fomepizole in methanol or ethylene glycol poisonings. An "adverse drug event" is harm associated with normal or incorrect drug use...
  66. ncbi Oximes: Reactivators of phosphorylated acetylcholinesterase and antidotes in therapy against tabun poisoning
    Zrinka Kovarik
    Institute for Medical Research and Occupational Health, Ksaverska c 2, Zagreb, Croatia
    Chem Biol Interact 175:173-9. 2008
    ..Promising oximes were further tested in vivo on tabun poisoned mice not only as antidotes in combination with atropine but also as pretreatment drug...
  67. pmc Multiple-dose activated charcoal in acute self-poisoning: a randomised controlled trial
    Michael Eddleston
    Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK
    Lancet 371:579-87. 2008
    ..We therefore aimed to assess whether routine treatment with multiple-dose activated charcoal, to interrupt enterovascular or enterohepatic circulations, offers benefit compared with no charcoal in such an environment...
  68. ncbi Reversal of arsenic-induced hepatic apoptosis with combined administration of DMSA and its analogues in guinea pigs: role of glutathione and linked enzymes
    Deepshikha Mishra
    Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Jhansi Road, Gwalior 474 002, India
    Chem Res Toxicol 21:400-7. 2008
    ..On the basis of the above observations, we recommend that combinational therapy of DMSA and its long carbon chain analogues MiADMSA or MchDMSA would be more effective in arsenic toxicity...
  69. ncbi Comparative treatment of alpha-amanitin poisoning with N-acetylcysteine, benzylpenicillin, cimetidine, thioctic acid, and silybin in a murine model
    Tri C Tong
    University of California San Diego Medical Center, Division of Medical Toxicology, Department of Emergency Medicine, San Diego, CA 92103, USA
    Ann Emerg Med 50:282-8. 2007
    ..We compare the effectiveness of 5 potential antidotal therapies in limiting the degree of hepatonecrosis in a randomized, controlled, murine model of amatoxin-induced hepatotoxicity...
  70. ncbi Hydroxocobalamin for severe acute cyanide poisoning by ingestion or inhalation
    Stephen W Borron
    University of Texas Health Science Center, San Antonio, TX 78229, USA
    Am J Emerg Med 25:551-8. 2007
    ..That 71% of patients survived after treatment with hydroxocobalamin suggests that hydroxocobalamin as first-line antidotal therapy is effective and safe in acute cyanide poisoning...
  71. ncbi Chemical terrorism attacks: update on antidotes
    David T Lawrence
    Blue Ridge Poison Center, Division of Medical Toxicology, Department of Emergency Medicine, University of Virginia, Charlottesville, VA 22908 0774, USA
    Emerg Med Clin North Am 25:567-95; abstract xi. 2007
    ..There are several antidotes that, if used correctly in a timely fashion, can help lessen the harm caused by these agents...
  72. ncbi The approach to the patient with an unknown overdose
    Timothy B Erickson
    Department of Emergency Medicine, Division of Clinical Toxicology, University of Illinois at Chicago, Toxikon Consortium, Chicago, IL 60612, USA
    Emerg Med Clin North Am 25:249-81; abstract vii. 2007
    ..Once the patient has been stabilized, the physician must consider how to minimize the bioavailability of toxin not yet absorbed, which antidotes (if any) to administer, and if other measures to enhance elimination are necessary.
  73. ncbi Novel nerve-agent antidote design based on crystallographic and mass spectrometric analyses of tabun-conjugated acetylcholinesterase in complex with antidotes
    F J Ekström
    FOI CBRN Defence and Security, Umea, Sweden
    Clin Pharmacol Ther 82:282-93. 2007
    ..Clinical treatment of nerve-agent poisoning is to use oxime-based antidotes to reactivate the inhibited AChE. However, the nerve agent tabun is resistant to oximes...
  74. ncbi Cyanide: critical issues in diagnosis and treatment
    F J Baud
    Department of Medical and Toxicological Critical Care, University Paris 7, INSERM U705, Hopital Lariboisiere, 2 rue Ambroise Pare, 75010 Paris, France
    Hum Exp Toxicol 26:191-201. 2007
    ..A number of experimentally efficient antidotes to cyanide exist, whose clinical use has been hampered due to serious side effects...
  75. ncbi Potential interference by hydroxocobalamin on cooximetry hemoglobin measurements during cyanide and smoke inhalation treatments
    Jangwoen Lee
    Laser Microbeam and Medical Program, Beckman Laser Institute, University of California, Irvine, CA, USA
    Ann Emerg Med 49:802-5. 2007
    ....
  76. pmc Management of acute organophosphorus pesticide poisoning
    Michael Eddleston
    Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, England
    Lancet 371:597-607. 2008
    ..Improved medical management of organophosphorus poisoning should result in a reduction in worldwide deaths from suicide...
  77. ncbi Safety of hydroxocobalamin in healthy volunteers in a randomized, placebo-controlled study
    Wolfgang Uhl
    Merck KGaA, Darmstadt, Germany
    Clin Toxicol (Phila) 44:17-28. 2006
    ..This randomized, double-blind, placebo-controlled, ascending-dose study was conducted in healthy volunteers to evaluate the safety of the investigational cyanide antidote hydroxocobalamin...
  78. ncbi Management of yellow oleander poisoning
    Senaka Rajapakse
    Department of Clinical Medicine, Faculty of Medicine, University of Colombo, Colombo 8, Sri Lanka
    Clin Toxicol (Phila) 47:206-12. 2009
    ..High cost and lack of availability limit the widespread use of digoxin-specific antibody fragments in developing countries...
  79. ncbi Patterns and problems of deliberate self-poisoning in the developing world
    M Eddleston
    Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK
    QJM 93:715-31. 2000
    ..Few of these poisons have specific antidotes. This emphasizes the importance of determining whether interventions aimed at reducing poison absorption ..
  80. ncbi Value of lactic acidosis in the assessment of the severity of acute cyanide poisoning
    Frederic J Baud
    Réanimation Médicale et Toxicologique and Inserm U26, Universite Paris 7, France
    Crit Care Med 30:2044-50. 2002
    ..pure cyanide poisoning because immediate laboratory confirmation of suspected cyanide poisoning is rarely possible and because clinicians must rapidly decide whether to administer specific antidotes, which may have severe side effects.
  81. ncbi The use of specific antidotes as a response to bleeding complications during anticoagulant therapy for venous thromboembolism
    D Haverkamp
    Department of Clinical Epidemiology, Academic Medical Center, Amsterdam, The Netherlands
    J Thromb Haemost 1:69-73. 2003
    ..have been developed that are likely to have some risk of bleeding complications, for which no specific antidotes are available. Interestingly, it is unknown how often the use of an antidote is necessary in clinical practice...
  82. ncbi Antidotal treatment of cyanide poisoning
    Bruno Megarbane
    Réanimation Médicale et Toxicologique, Universite Paris VII, INSERM U26, Hospital Lariboisiere, Paris, France
    J Chin Med Assoc 66:193-203. 2003
    ..Many antidotes are available and efficient. However, therapeutic strategies are still debated...
  83. pmc Self poisoning with pesticides
    Michael Eddleston
    Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Oxford
    BMJ 328:42-4. 2004
  84. ncbi Poisons. Initial assessment and management
    Sally M Bradberry
    National Poisons Information Service Birmingham Centre and West Midlands Poisons Unit, City Hospital, Birmingham
    Clin Med 3:107-10. 2003
  85. ncbi Methanol ingestion: prevention of toxic sequelae after massive ingestion
    Karen A Lushine
    Department of Emergency Medicine, Regions Hospital, St Paul, Minnesota 55101, USA
    J Emerg Med 24:433-6. 2003
    ..Treatment of the methanol-poisoned patient with Fomepizole is discussed...
  86. ncbi Neuroprotective effects of currently used antidotes in tabun-poisoned rats
    Jiri Kassa
    Purkyne Military Medical Academy, 500 01 Hradec Kralove, Czech Republic
    Pharmacol Toxicol 92:258-64. 2003
    The neuroprotective effects of antidotes (atropine, pralidoxime/atropine, obidoxime/atropine and HI-6/atropine mixtures) on rats poisoned with tabun at a lethal dose (220 microg/kg intramuscularly; 100% of LD50 value) were studied...
  87. ncbi Acetaminophen-induced hepatotoxicity
    Laura P James
    Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
    Drug Metab Dispos 31:1499-506. 2003
    ..Other cytokines, such as IL-10, macrophage inhibitory protein-2 (MIP-2), and monocyte chemoattractant protein-1 (MCP-1), appear to be involved in hepatocyte repair and the regulation of proinflammatory cytokines...
  88. pmc Respiratory failure in acute organophosphorus pesticide self-poisoning
    M Eddleston
    Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK
    QJM 99:513-22. 2006
    ..Delayed failure appears to be due to respiratory muscle weakness, but its pathophysiology is unclear...
  89. ncbi Rational design and molecular diversity for the construction of anti-alpha-bungarotoxin antidotes with high affinity and in vivo efficiency
    Luisa Lozzi
    Department of Molecular Biology, University of Siena, Via Fiorentina 1, I 53100 Siena, Italy
    Chem Biol 10:411-7. 2003
    ..The tetra-branched forms of the resulting high-affinity peptides were effective as antidotes in vivo at a significantly lower dose than the tetra-branched lead peptide.
  90. ncbi Pediatric toxicologic concerns
    Gina Abbruzzi
    Department of Emergency Medicine, State University of New York, Upstate Medical University, Syracuse, New York, USA
    Emerg Med Clin North Am 20:223-47. 2002
    ..must keep current with advances in toxicology to be familiar with the latest recommended treatment regimens and antidotes. They also must be familiar in identifying toxidromes and important physical examination findings...
  91. ncbi Multiple centrally acting antidotes protect against severe organophosphate toxicity
    Marco L A Sivilotti
    Department of Emergency Medicine, Queen s University, Kingston, Ontario, Canada
    Acad Emerg Med 13:359-64. 2006
    ..Diazepam is known to supplement atropine therapy, but its specific mechanism of action is uncertain...
  92. ncbi Evaluation of reactivation test in anaesthetized dogs with experimental intoxication with nerve agents
    J Bajgar
    Department of Toxicology, Faculty of Military Health Sciences, University of Defence, Trebesska 1575, 500 01 Hradec Kralove, Czech Republic
    J Appl Toxicol 26:439-43. 2006
    ..Thus, the reactivation efficacy of obidoxime during nerve agent intoxication indicates that its repeated administration could be easily monitored using the reactivation test...
  93. ncbi Availability, stability, and sterility of pralidoxime for mass casualty use
    Timothy F Corvino
    Department of Emergency Medicine, Ohio State University, Columbus, OH, USA
    Ann Emerg Med 47:272-7. 2006
    ..Our study describes a method to convert the intramuscular formulation for intravenous use and determines the stability and sterility of the resulting formulation over time and under various environmental conditions...
  94. ncbi Structural requirements of acetylcholinesterase reactivators
    Kamil Kuca
    Department of Toxicology, Faculty of Military Health Sciences, Trebesska 1575, 500 01 Hradec Kralove, Czech Republic
    Mini Rev Med Chem 6:269-77. 2006
    ..It is shown that there are several structural fragments possibly involving in the structure of proposed AChE reactivators. Finally, an attempt of a future course of new AChE reactivators development is discussed...
  95. pmc Acetylcholinesterase: converting a vulnerable target to a template for antidotes and detection of inhibitor exposure
    Palmer Taylor
    Department of Pharmacology, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093 0650, USA
    Toxicology 233:70-8. 2007
    ..templates and fluorescence detection of organophosphorylation provide unexplored avenues for development of antidotes and approaches for remote detection of organophosphate nerve agents and pesticides...
  96. ncbi Transient and reversible nephrotoxicity of sarin in rats
    Eugenia Bloch-Shilderman
    Department of Pharmacology, Israel Institute for Biological Research, Ness Ziona P O Box 19, 74100, Israel
    J Appl Toxicol 27:189-94. 2007
    ..However, if renal impairments are left unattended, they might contribute to the overall toxic manifestation and as a result aggravate the clinical state of intoxicated casualties...
  97. ncbi In vitro potency of H oximes (HI-6, HLö-7), the oxime BI-6, and currently used oximes (pralidoxime, obidoxime, trimedoxime) to reactivate nerve agent-inhibited rat brain acetylcholinesterase
    Kamil Kuca
    Department of Toxicology, Faculty of Military Health Sciences, Hradec Kralove, Czech Republic
    J Toxicol Environ Health A 69:1431-40. 2006
    ..More than one oxime may be necessary for the antidotal treatment of nerve agent-exposed individuals...
  98. ncbi Pyridinium, imidazolium and quinuclidinium compounds: toxicity and antidotal effects against the nerve agents Tabun and Soman
    Elsa Reiner
    Institute for Medical Research and Occupational Health, Zagreb, Croatia
    Arh Hig Rada Toksikol 57:171-9. 2006
    ..Screening studies have shown that these compounds combined with atropine are effective antidotes against the organophosphate nerve agents Tabun and/or Soman, having a therapeutic factor equal or greater than 2...
  99. ncbi Comparison of effects of different antidotes on tabun-induced cognitive impairment in rats using water maze
    Gabriela Kunesova
    University of Defence, Department of Toxicology, Faculty of Military Health Sciences, Hradec Kralove, Czech Republic
    Acta Medica (Hradec Kralove) 49:113-8. 2006
    In the past, scientists focused on the development of antidotes (mainly anticholinergics in combination with reactivators of inhibited acetylcholinesterase-oximes) to increase the number of surviving nerve agent-intoxicated individuals...
  100. ncbi Pretreatment with pyridinium oximes improves antidotal therapy against tabun poisoning
    Ana Lucić Vrdoljak
    Institute for Medical Research and Occupational Health, Ksaverska c 2, Zagreb, Croatia
    Toxicology 228:41-50. 2006
    ....
  101. ncbi Antidotal efficacy of pyridinium chloride derivatives against soman poisoning
    Ana Lucic Vrdoljak
    Unit of Toxicology, Institute for Medical Research and Occupational Health, Ksaverska c 2, HR 10000 Zagreb, Croatia
    Basic Clin Pharmacol Toxicol 99:17-21. 2006
    ..The type of the substituent in the pyridinium ring generally has a significant influence on toxicity in vitro and in vivo, and on the antidotal efficacy of all new tested compounds...

Research Grants62

  1. Controlling Radiation Injury by TLR5 Agonists
    Andrei V Gudkov; Fiscal Year: 2012
    ..Completion of this program will provide critical information about an emerging class of radiation antidotes that will allow improved understanding of their potential as human therapeutics targeting acute radiation ..
  2. Protection of Brain Injury from Cyanide Poisoning by Carnosic Acid
    Stuart A Lipton; Fiscal Year: 2013
    ..Such acute toxicity is treatable by various antidotes, but success depends on rapid administration and effective penetration of the various tissues...
  3. KINETICS OF DRUG MACROMOLECULE COMPLEX FORMATION
    PALMER WILLIAM TAYLOR; Fiscal Year: 2013
    ..receptor ligands for depression, schizophrenia, pain alleviation and nicotine addiction and AChE inhibitor antidotes. Our fundamental studies with the extracellular domain of the three proteins are now based on structure at ..
  4. High affinity capturing agents for strychnine
    Kit S Lam; Fiscal Year: 2011
    ..We shall apply the enabling OBOC combinatorial library method to discover antidotes for strychnine...
  5. Detoxification of Electrophilic Chemical Threat Agents by Nucleophilic Scavengers
    Michael C MacLeod; Fiscal Year: 2010
    ..This will allow us to begin to formulate novel antidotes that could be used to protect personnel responding to an incident involving SNMs, and to stabilize exposed ..
  6. Brain tumors with regulatory T-cells treated with EGFRvIII-specific T-cells
    John H Sampson; Fiscal Year: 2013
    ..Using this peptide, we have shown that these cognate peptides are sufficient antidotes for CARs, suggesting a novel paradigm for reducing the target-specific toxicity of less tumor-specific CARs...
  7. Developmental neurotoxicity of sarin and soman in guinea pigs
    Edson X Albuquerque; Fiscal Year: 2012
    ..of the developing mammalian central nervous system (CNS) to organophosphorus (OP) nerve agents and the safety of antidotes such as atropine and pralidoxime, commonly used against acute OP toxicity, in pregnant women and the developing ..
  8. Role of the ribosomal stalk in the activity of Shiga toxins
    Nilgun E Tumer; Fiscal Year: 2013
    ..coli strains are foodborne pathogens that can cause serious and sometimes fatal effects. There are no antidotes or therapeutics effective against Shiga toxin-mediated hemolytic uremic syndrome (HUS)...
  9. Therapeutic Intervention of Lewisite-Mediated Cutaneous Blistering-Inflammation
    Mohammad Athar; Fiscal Year: 2013
    ..employ a novel murine model to unravel the molecular mechanism of lewisite in order to develop mechanism-based antidotes/therapy...
  10. Crystalline hydroxocobalamin and methemoglobin as a treatment of H2S intoxication
    PHILIPPE A HAOUZI; Fiscal Year: 2013
    ..The goal of this project is to test the hypothesis that solutions of methemoglobin or Vitamin B12 can be used as antidotes following H2S exposure...
  11. Aerosol Delivery of a Recombinant Butyrylcholinesterase "BioShield" to Protect Ag
    YVONNE J ROSENBERG; Fiscal Year: 2012
    ..Public Health Relevance: Many glycoproteins which are potent antidotes, exhibit very important physiological functions but cannot be used as therapeutic treatments because they are ..
  12. Age and sex effects on nerve agent damage to the brain and antidotal therapies
    Edson X Albuquerque; Fiscal Year: 2010
    ..The limitations of available therapies against OP poisoning are well recognized, and more effective antidotes have to be developed...
  13. C. elegans as a model for ricin intoxication
    Nilgun E Tumer; Fiscal Year: 2010
    ..These studies are significant because currently there are no vaccines, antidotes or any other treatment measures against ricin exposure...
  14. Testing the Vitamin B12 Analog Cobinamide Against Selected Chemical Threats
    Gerry R Boss; Fiscal Year: 2012
    ..Unfortunately, specific antidotes that can be administered quickly in the field are not available for many of these chemicals...
  15. Nitrites as Antidotes for Hydrogen Sulfide Poisoning
    James Peterson; Fiscal Year: 2013
    ..abstract_text> ..
  16. Synthetic surfactant and toxic chemical lung injury
    Frans J Walther; Fiscal Year: 2011
    ..Although these effects are well understood, the absence of specific antidotes has limited the effectiveness of prior therapeutic interventions...
  17. Antidotes to Anthrax Lethal Factor Intoxication
    ALAN THOMAS JOHNSON; Fiscal Year: 2012
    ..The goal of this research is to identify a safe and effective drug capable of acting as an antidote to the toxic effects due to anthrax exposure to combat this continuing and real threat. ..
  18. Antithrombotic Aptamers and Antidotes
    BRUCE ALAN SULLENGER; Fiscal Year: 2013
    ..by applicant): The central hypothesis being tested in this proposal is that anticoagulant aptamers and their antidotes represent a safe and effective means of controlling coagulation and preventing thrombosis...
  19. Novel therapeutic approaches to treatment of botulinum neurotoxin poisoning
    Eric A Johnson; Fiscal Year: 2013
    ..Developing antidotes to botulinum neurotoxins is a priority goal of the Biodefense Research Agenda...
  20. Improved standard of care reactivaters and facilitative transport into the centra
    GREGORY EDWARD GARCIA; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The use of chemical antidotes is likely the first treatment for civilian and military-installation nerve agent (NA) casualties...
  21. Motor neuron-targeted adenovirus antidotes for botulism
    CHARLES BIX SHOEMAKER; Fiscal Year: 2013
    ..Here we propose to develop adenovirus-based botulism antidotes that will specifically target motor neurons and lead to cytosolic expression of a TFB agent within intoxicated ..
  22. PROTECTION AGAINST ORGANOPHOSPHATE NEUROTOXINS BY TOBACCO CEMBRANOIDS
    P A Ferchmin; Fiscal Year: 2010
    ..The classic antidotes now in use protect against a wide spectrum of neural injury and dramatically decrease mortality...
  23. Acute Cyanide Toxicity, Complex IV, NO & Nitrite
    James Peterson; Fiscal Year: 2010
    ..Enthusiasm for the use of traditional antidotes, nitrites (amyl and/or sodium nitrite), has decreased, in part, because of the uncertain assumption that its ..
  24. Fullerenes Counteracting Organophosphorus Threats
    Marion F Ehrich; Fiscal Year: 2010
    ..We predict that soluble C60/C80 derivatives can be safely administered as OP antidotes, either alone or in combination with currently accepted treatments (IV atropine, pralidoxime, diazepam)...
  25. What makes ricin toxic
    Nilgun E Tumer; Fiscal Year: 2013
    ..Therefore, understanding how ricin kills cells and developing antidotes to protect exposed people remain top health priorities...
  26. Pharmacotherapy to counterACT parathion-induced NMJ dysfunction
    Steven B Bird; Fiscal Year: 2013
    ..However, these antidotes have limited effectiveness and between 10 and 40% of patients, depending on the responsible OP, still die even ..
  27. Novel Neuromuscular Protection to CounterACT Organophosphorus (OP) Poisoning
    Steven B Bird; Fiscal Year: 2012
    ..However, these antidotes have limited effectiveness and between 10 and 40% of patients, depending on the responsible OP, still die even ..
  28. The Role of Ubiquitination in Methamphetamine Neurotoxicity (CDA)
    Anna Moszczynska; Fiscal Year: 2012
    ..To date, there are no safe and tested medications for treating MA addiction and new MA antidotes for use by emergency room physicians to treat MA-related overdoses are needed...
  29. A platform for therapeutic agents that promote rapid recovery from botulism
    CHARLES BIX SHOEMAKER; Fiscal Year: 2013
    ..In contrast, the innovative new platform for biomolecule therapeutics that we propose to develop has the potential to quickly lead to commercially viable antidotes for all BoNT serotypes.
  30. Nanoparticle scavengers for medical countermeasures against mycotoxin
    Zhiguo Zhou; Fiscal Year: 2013
    ..The nanoparticle antidotes could be important for the Strategic National Stockpile in preparing for an emergency involving bioterrorism...
  31. A Discovery and Development Pipeline for Cyanide Countermeasures
    Raymond J Peterson; Fiscal Year: 2013
    ..Currently available antidotes simply do not match the complexity or scale of the potential mass casualty threat scenarios, and there is an ..
  32. Rapid development of in vivo models for countermeasure discovery: organophosphate
    Randall T Peterson; Fiscal Year: 2010
    ..in chemical countermeasure discovery is the potential emergence of novel agents for which there are no known antidotes or post exposure therapies...
  33. Combined Use of Cobinamide and a 3-Mercaptopyruvate Prodrug for Cyanide Poisoning
    Steven E Patterson; Fiscal Year: 2011
    ..We (Nagasawa et al) have recently developed a series of prototype cyanide antidotes that detoxify cyanide by converting cyanide to the non-toxic thiocyanate...
  34. Countermeasures Against Chemical Threats: Countermeasures Against Cyanide
    Steven E Patterson; Fiscal Year: 2012
    ..However, there are no such available treatments - the current cyanide antidotes are administered intravenously...
  35. RNA aptamers as novel antidotes against botulism
    Shuowei Cai; Fiscal Year: 2009
    ..The only approved antidotes are equine antitoxins, which can only neutralize the toxin in the blood circulation, and have a very short ..
  36. Enzyme & Receptor Antagonists of GHB, GBL & 1, 4-BD
    Lawrence Quang; Fiscal Year: 2003
    ..The third aim is to investigate potential antidotes for acute 1,4-BD overdose and combined acute 1,4-BD and ETOH overdose...
  37. Novel anticonvulsant and neuroprotective therapies for TETS and OP intoxication
    Pamela J Lein; Fiscal Year: 2013
    ..combinations for treatment of seizures triggered by chemical threat agents, in parallel with evaluation of new antidotes based on strong preliminary efficacy data...
  38. Development of amodiaquine and its analogs as reactivators of organophosphate-inh
    Donald W Landry; Fiscal Year: 2013
    ..Part of the issue is that broad-spectrum antidotes to reverse the effects of OPC exposure have yet to be developed...
  39. Nuclease-Resistant Aptamers to Botox and Anthrax Toxins
    John Bruno; Fiscal Year: 2004
    ..of "shielded" (nuclease-resistant) aptamers as toxin inhibitors with greater affinity than antibodies or other antidotes, in general, guarantees the owner of the technology entry into a growing biodefense market...
  40. Ginkgo Biloba: Antidepressant-Induced Sexual Dysfunction
    Cindy Meston; Fiscal Year: 2003
    ..To date, there are no effective pharmacological antidotes for treating these sexual side effects...
  41. Peptide & antibodies as antidotes for superantigens
    Kunwar Shailubhai; Fiscal Year: 2006
    ..Successful accomplishment of these goals will permit us to take the lead candidates into clinical trials in humans. [unreadable] [unreadable]..
  42. Intraosseous Auto-injector Delivery of Antidotes
    STEPHEN BRUTTIG; Fiscal Year: 2005
    ..has developed FirstMed, an intraosseous auto-injector for self- or buddy-administration of emergency antidotes and drugs...
  43. Enhancement of Thrombolysis through Inhibition of PAI-1 and Antiplasmin
    CHARLENE BLAKE; Fiscal Year: 2007
    ..In addition, I will utilize rational drug design to develop antidotes specific to these RNA molecules, resulting in a drug-antidote pair...
  44. New Therapeutic Approach for Ricin-Induced Lung Injury
    Kam Meng Tchou Wong; Fiscal Year: 2007
    ..Health: Since there is currently no treatment for ricin toxicity, there is an urgent need to develop effective antidotes for ricin...
  45. Nicotinic receptor-mediated action of tobacco nitrosamines on respiratory cells
    SERGEI GRANDO; Fiscal Year: 2007
    ..in respiratory cells to mediating the oncogenic action of the nicotine-derived nitrosamines and identify antidotes to the tobacco-related carcinogenesis...
  46. ANTIDOTES OF PHENCYCLIDINE TOXICITY
    PAUL CONSROE; Fiscal Year: 1980
    ..Additional studies in dogs and rats are ongoing to determine more fully the potential usefulness of activated charcoal as an antidote for PCP intoxication in humans. ..
  47. Development of novel proteins as a defence against potential biothreat agents
    ALEXEY ZDANOVSKY; Fiscal Year: 2007
    ..Also, antibodies are expensive to produce and when used as antidotes cannot inactivate agents that have been already internalized into the cells...
  48. RESPIRATORY TOXICITY OF PHENCYCLIDINE AND RELATED ABUSE
    GEORGE YIM; Fiscal Year: 1980
    ..b>Antidotes are available to help manage the hypertensive, convulsive and pyschotic reactions seen in PCP overdosage, but ..
  49. LPS-specific Aptamers for Microbial Detection
    Marit Nilsen Hamilton; Fiscal Year: 2004
    ..and could be used for bioterrorism emphasizes the need to readily detect pathogenic bacteria and of having antidotes to protect against them. Antibodies are a very important means of detecting specific LPS molecules...
  50. POISONOUS DINOFLAGELLATES AND SHELLFISH POISONING
    HEINRICH SCHNOES; Fiscal Year: 1980
    ..of rapid and quantitative toxin assay procedures, the elucidation of the biosynthesis of saxitoxin, and of environmental and biochemical parameters effecting toxin production, and the search for effective antidotes against these poisons.
  51. Opiate Withdrawal & Tolerance: Development & Plasticity
    Gordon Barr; Fiscal Year: 2006
    ..similar to those of the adult, we have recently discovered that NMDA glutamate antagonists, which are effective antidotes for withdrawal and tolerance to opiates in the adult, are fully ineffective in the infant rat and may indeed ..
  52. The Role of Ubiquitination in Methamphetamine Neurotoxicity (CDA)
    Anna Moszczynska; Fiscal Year: 2009
    ..To date, there are no safe and tested medications for treating MA addiction and new MA antidotes for use by emergency room physicians to treat MA-related overdoses are needed...
  53. Cannabinoids in Early Sea Urchin Development
    Jean Lauder; Fiscal Year: 2005
    ..We will determine cell phenotype changes evoked by cannabinoids and search for potential antidotes to prevent them, including new lipophilic cannabinoid receptor antagonists...
  54. FACILITIES CONSTRUCTION CENTERALIZED PHARMCOGENOMICS
    Palmer Taylor; Fiscal Year: 2003
    ..The Centralized Animal Facility is critically needed to support this effort and allow economies of scale for animal research. ..
  55. Nicotinic Receptor Template-guided Drug Design
    Palmer Taylor; Fiscal Year: 2008
    ..The final stages of investigation will include studies in rodents to determine efficacy and toxicity. ..
  56. KINETICS OF DRUG MACROMOLECULE COMPLEX FORMATION
    Palmer Taylor; Fiscal Year: 2008
    ..abstract_text> ..
  57. NOVEL THERAPIES FOR ACETAMINOPHEN TOXICITY
    Laura James; Fiscal Year: 2004
    ..abstract_text> ..
  58. Evaluation of a Biomarker for Acetaminophen Toxicity
    Laura James; Fiscal Year: 2005
    ..The data generated from this study will lead to enhanced recognition of APAP hepatotoxicity, thus allowing for better identification of "at risk" populations and the creation of prevention strategies. ..
  59. Fetal & Adolescent Nicotine Effects on CNS 5HT Systems
    Theodore Slotkin; Fiscal Year: 2003
    ..abstract_text> ..