protective agents

Summary

Summary: Synthetic or natural substances which are given to prevent a disease or disorder or are used in the process of treating a disease or injury due to a poisonous agent.

Top Publications

  1. pmc Carbon monoxide induces hypothermia tolerance in Kupffer cells and attenuates liver ischemia/reperfusion injury in rats
    Lung Yi Lee
    Thomas E Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Liver Transpl 17:1457-66. 2011
  2. ncbi Protective effect of caffeic acid phenethyl ester (CAPE) administration on cisplatin-induced oxidative damage to liver in rat
    Mustafa Iraz
    Inonu University, Faculty of Medicine, Department of Pharmacology, Malatya, Turkey
    Cell Biochem Funct 24:357-61. 2006
  3. ncbi Protection from thymic epithelial cell injury by keratinocyte growth factor: a new approach to improve thymic and peripheral T-cell reconstitution after bone marrow transplantation
    Dullei Min
    Division of Research Immunology BMT, Childrens Hospital Los Angeles, CA 90027, USA
    Blood 99:4592-600. 2002
  4. ncbi Protective role of selenium against renal toxicity induced by cadmium in rats
    A S el-Sharaky
    Department of Biochemistry, Faculty of Science, Alexandria University, Alexandria, Egypt
    Toxicology 235:185-93. 2007
  5. ncbi NF-kappaB pathway protects cochlear hair cells from aminoglycoside-induced ototoxicity
    Hongyan Jiang
    Kresge Hearing Research Institute, Department of Otolaryngology, University of Michigan, Ann Arbor, Michigan 48109 0506, USA
    J Neurosci Res 79:644-51. 2005
  6. ncbi Melatonin enhances endogenous heme oxygenase-1 and represses immune responses to ameliorate experimental murine membranous nephropathy
    Chia Chao Wu
    Division of Nephrology, Department of Medicine, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan
    J Pineal Res 52:460-9. 2012
  7. ncbi Effect of noble gases on oxygen and glucose deprived injury in human tubular kidney cells
    Maleeha Rizvi
    Anaesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Imperial College London, London, UK
    Exp Biol Med (Maywood) 235:886-91. 2010
  8. ncbi Protective effects of catechin and quercetin on antioxidant status, lipid peroxidation and testis-histoarchitecture induced by chlorpyrifos in male rats
    Yusuf Kalender
    Gazi University, Faculty of Science, Department of Biology, Ankara, Turkey
    Environ Toxicol Pharmacol 33:141-8. 2012
  9. ncbi The unsolved cyclosporine-induced kidney injury: is paricalcitol a feasible new renoprotective option?
    Flávio N F Reis
    Institute of Pharmacology and Experimental Therapeutics, Institute of Biomedical Research on Light and Image IBILI, Medicine Faculty, Coimbra University, 3000 354 Coimbra, Portugal
    Kidney Int 77:1055-7. 2010
  10. pmc The protective effects of cerium oxide nanoparticles against hepatic oxidative damage induced by monocrotaline
    Kamal A Amin
    Department of Biochemistry, Faculty of Veterinary Medicine, Beni Suef University, Beni Suef, Egypt
    Int J Nanomedicine 6:143-9. 2011

Detail Information

Publications280 found, 100 shown here

  1. pmc Carbon monoxide induces hypothermia tolerance in Kupffer cells and attenuates liver ischemia/reperfusion injury in rats
    Lung Yi Lee
    Thomas E Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Liver Transpl 17:1457-66. 2011
    ..In conclusion, the pretreatment of donors with CO ameliorates LT-associated I/R injury with increased hepatic HSP70 expression, particularly in the KC population...
  2. ncbi Protective effect of caffeic acid phenethyl ester (CAPE) administration on cisplatin-induced oxidative damage to liver in rat
    Mustafa Iraz
    Inonu University, Faculty of Medicine, Department of Pharmacology, Malatya, Turkey
    Cell Biochem Funct 24:357-61. 2006
    ..It can be concluded that CAPE may prevent cisplatin-induced oxidative changes in liver by strengthening the antioxidant defence system by reducing reactive oxygen species and increasing antioxidant enzyme activities...
  3. ncbi Protection from thymic epithelial cell injury by keratinocyte growth factor: a new approach to improve thymic and peripheral T-cell reconstitution after bone marrow transplantation
    Dullei Min
    Division of Research Immunology BMT, Childrens Hospital Los Angeles, CA 90027, USA
    Blood 99:4592-600. 2002
    ..Furthermore, thymic injury and prolonged posttransplantation immune deficiency in BMT recipients can be prevented by KGF administration...
  4. ncbi Protective role of selenium against renal toxicity induced by cadmium in rats
    A S el-Sharaky
    Department of Biochemistry, Faculty of Science, Alexandria University, Alexandria, Egypt
    Toxicology 235:185-93. 2007
    ..These results could be important for the further understanding of the complex mechanisms of cadmium toxicity in kidney tissues and in the development of better treatments for people and/or animals exposed to the heavy metal...
  5. ncbi NF-kappaB pathway protects cochlear hair cells from aminoglycoside-induced ototoxicity
    Hongyan Jiang
    Kresge Hearing Research Institute, Department of Otolaryngology, University of Michigan, Ann Arbor, Michigan 48109 0506, USA
    J Neurosci Res 79:644-51. 2005
    ..These results suggest that changes in the redox state of the cochlea stimulate the activation of NF-kappaB and that this activation is cell protective...
  6. ncbi Melatonin enhances endogenous heme oxygenase-1 and represses immune responses to ameliorate experimental murine membranous nephropathy
    Chia Chao Wu
    Division of Nephrology, Department of Medicine, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan
    J Pineal Res 52:460-9. 2012
    ..Melatonin should be considered a potential therapeutic intervention for MN in the future...
  7. ncbi Effect of noble gases on oxygen and glucose deprived injury in human tubular kidney cells
    Maleeha Rizvi
    Anaesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Imperial College London, London, UK
    Exp Biol Med (Maywood) 235:886-91. 2010
    ..These results suggest that unlike other noble gases, preconditioning with the anesthetic noble gas xenon may have a role in protection against renal ischemic injury...
  8. ncbi Protective effects of catechin and quercetin on antioxidant status, lipid peroxidation and testis-histoarchitecture induced by chlorpyrifos in male rats
    Yusuf Kalender
    Gazi University, Faculty of Science, Department of Biology, Ankara, Turkey
    Environ Toxicol Pharmacol 33:141-8. 2012
    ..Thus, it appears that catechin and quercetin ameliorate chlorpyrifos induced toxicity except histopathological changes in rat testis tissues...
  9. ncbi The unsolved cyclosporine-induced kidney injury: is paricalcitol a feasible new renoprotective option?
    Flávio N F Reis
    Institute of Pharmacology and Experimental Therapeutics, Institute of Biomedical Research on Light and Image IBILI, Medicine Faculty, Coimbra University, 3000 354 Coimbra, Portugal
    Kidney Int 77:1055-7. 2010
    ..Before paricalcitol can be considered a feasible new therapeutic option for post-transplantation nephropathy, these interesting data require further studies assessing other mechanisms of CsA-induced nephrotoxicity...
  10. pmc The protective effects of cerium oxide nanoparticles against hepatic oxidative damage induced by monocrotaline
    Kamal A Amin
    Department of Biochemistry, Faculty of Veterinary Medicine, Beni Suef University, Beni Suef, Egypt
    Int J Nanomedicine 6:143-9. 2011
    ..The objective of the present study was to determine the ability of cerium oxide (CeO(2)) nanoparticles to protect against monocrotaline (MCT)-induced hepatotoxicity in a rat model...
  11. ncbi Protective role of caffeic acid phenethyl ester (cape) on gentamicin-induced acute renal toxicity in rats
    H Parlakpinar
    Department of Pharmacology, Faculty of Medicine, Inonu University, 44280 Malatya, Turkey
    Toxicology 207:169-77. 2005
    ..Our results indicated that CAPE acts in the kidney as a potent scavenger of free radicals to prevent the toxic effects of GEN both at the biochemical and histological level. Thus, CAPE could be effectively combined with GEN treatment...
  12. ncbi Atorvastatin improving renal ischemia reperfusion injury via direct inhibition of active caspase-3 in rats
    John L Haylor
    Academic Nephrology Unit, University of Sheffield, Sheffield, UK
    Exp Biol Med (Maywood) 236:755-63. 2011
    ..This new inhibitory mechanism of AT may improve reperfusion tolerance in ischemic kidneys and benefit transplant recipients...
  13. ncbi Salubrious effect of C-phycocyanin against oxalate-mediated renal cell injury
    Shukkur Muhammed Farooq
    Department of Medical Biochemistry, Dr AL Mudaliar Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai 600 113, India
    Clin Chim Acta 348:199-205. 2004
    ....
  14. pmc Epoetin delta reduces oxidative stress in primary human renal tubular cells
    Annelies De Beuf
    Laboratory of Pathophysiology, Faculties of Medicine and Biomedical, Pharmaceutical and Veterinary Sciences, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium
    J Biomed Biotechnol 2010:395785. 2010
    ....
  15. ncbi Agents ameliorating or augmenting the nephrotoxicity of cisplatin and other platinum compounds: a review of some recent research
    Badreldin H Ali
    Department of Pharmacology and Clinical Pharmacy, College of Medicine, Sultan Qaboos University, P O Box 35, Al Khod, Muscat 123, Oman
    Food Chem Toxicol 44:1173-83. 2006
    ..Those agents that have been shown to augment cisplatin nephrotoxicity include nitric oxide synthase inhibitors, spironolactone, gemcitabine and others. Combining these agents with cisplatin should be avoided...
  16. ncbi Curcumin restores Nrf2 levels and prevents quinolinic acid-induced neurotoxicity
    Iván Carmona-Ramírez
    Patología Vascular Cerebral, Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez, Mexico D F, 14269, Mexico
    J Nutr Biochem 24:14-24. 2013
    ....
  17. ncbi Emulsified intravenous versus evaporated inhaled isoflurane for heart protection: old wine in a new bottle or true innovation?
    Eliana Lucchinetti
    Anesth Analg 106:1346-9. 2008
  18. ncbi Protective effect of ginsenoside Rg1 on glutamate-induced lung injury
    Li Shen
    Departments of Physiology, Xiangya Medical School, Central South University, Changsha 410078, China
    Acta Pharmacol Sin 28:392-7. 2007
    ..To examine the possible protective effect of ginsenoside Rg1, an active component of ginseng, on lung injury caused by glutamate in vivo...
  19. ncbi Protective effect of selenium-enriched Lactobacillus on CCl4-induced liver injury in mice and its possible mechanisms
    Long Chen
    College of Life Sciences, Nanjing Normal University, Nanjing 210097, Jiangsu Province, China
    World J Gastroenterol 11:5795-800. 2005
    ..To study the protective effects and mechanisms of Se-enriched lactobacillus on liver injury caused by carbon tetrachloride (CCl4) in mice...
  20. ncbi Keratinocyte growth factor preserves normal thymopoiesis and thymic microenvironment during experimental graft-versus-host disease
    Simona Rossi
    Department of Research, University Hospital, Basel, Switzerland
    Blood 100:682-91. 2002
    ..Thus, pharmacologic doses of KGF appear to exert a potent effect on TEC function, which in turn allows for normal T lymphopoiesis to occur during acute GVHD...
  21. ncbi Hydrogen sulfide prevents ethanol-induced gastric damage in mice: role of ATP-sensitive potassium channels and capsaicin-sensitive primary afferent neurons
    Jand Venes R Medeiros
    Department of Physiology, Federal University of Ceara, Fortaleza, Ceara, Brazil
    J Pharmacol Exp Ther 330:764-70. 2009
    ..Although there are many mechanisms through which this effect can occur, our data support the hypothesis that the activation of K(ATP) channels and afferent neurons/TRPV1 receptors is of primary importance...
  22. ncbi Flavonoid antioxidant silymarin and skin cancer
    Rana P Singh
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Antioxid Redox Signal 4:655-63. 2002
    ....
  23. ncbi Antioxidant and protective effect of an oleanolic acid-enriched extract of A. deliciosa root on carbon tetrachloride induced rat liver injury
    Xinpeng Bai
    The Key Lab of Food Science and Safety, Ministry of Education, Southern Yangtze University, Wuxi, China 214036
    Asia Pac J Clin Nutr 16:169-73. 2007
    ..The findings indicate that the OLA-enriched EEAD-Bu extract had significant and concentration dependent hepatoprotective effect for the carbon tetrachloride induced rat liver injury...
  24. ncbi Protective effect of quercetin on renal ischemia/reperfusion injury in rats
    Ahmet Kahraman
    Department of Biochemistry, The School of Medicine, Kocatepe University, Afyon 03200, Turkey
    J Nephrol 16:219-24. 2003
    ..The aim of this study was to evaluate whether quercetin, an oxygen free radical scavenger, protects kidney tissue...
  25. ncbi Emulsified isoflurane produces cardiac protection after ischemia-reperfusion injury in rabbits
    Yan Rao
    Department of Anesthesiology, Zhongnan Hospital of Wuhan University, Wuhan 430071, Hubei, China
    Anesth Analg 106:1353-9, table of contents. 2008
    ..In this study, we examined the cardioprotective effects of parental emulsified isoflurane compared with inhaled isoflurane...
  26. ncbi Grape seed proanthocyanidins protect cardiomyocytes from ischemia and reperfusion injury via Akt-NOS signaling
    Zuo Hui Shao
    Department of Medicine, Emergency Resuscitation Center, University of Chicago, Illinois 60637, USA
    J Cell Biochem 107:697-705. 2009
    ..GSPE offers an alternative approach to therapeutic cardioprotection against I/R injury and may offer unique opportunities to improve cardiovascular health by enhancing NO production and increasing Akt-eNOS signaling...
  27. ncbi The protective effect of alpha-tocopherol and GdCl3 against hepatic ischemia/reperfusion injury
    Dimitrios Giakoustidis
    Department of Transplantation Surgery, Medical School, Aristotle University, Hippokration Hospital, Konstantinoupoleos 49, 54642, Thessaloniki, Greece
    Surg Today 36:450-6. 2006
    ..To evaluate the combined effect of alpha-tocopherol and gadolinium chloride (GdCl3) in reducing lipid peroxidation after severe hepatic ischemia/reperfusion (IR) injury...
  28. ncbi Induction of lactadherin mediates the apoptosis of endothelial cells in response to advanced glycation end products and protective effects of grape seed procyanidin B2 and resveratrol
    Bao Ying Li
    Key Laboratory of Cardiovascular Proteomics of Shandong Province, Department of Geriatrics, Qi Lu Hospital of Shandong University, Jinan, 250012, Shandong Province, People s Republic of China
    Apoptosis 16:732-45. 2011
    ..Targeting lactadherin with antioxidant could be translated into clinical application in the fighting against DM complications...
  29. ncbi Cytoprotective effect on oxidative stress and inhibitory effect on cellular aging of Terminalia chebula fruit
    Minkyun Na
    College of Pharmacy, Chungnam National University, Daejeon, Korea
    Phytother Res 18:737-41. 2004
    ..chebula extract on the age-dependent shortening of the telomere, length as shown by the Southern blots of the terminal restriction fragments (TRFs) of DNA extracted from subculture passages...
  30. pmc Identification of hepatoprotective flavonolignans from silymarin
    Stephen J Polyak
    Department of Laboratory Medicine, Microbiology and Global Health, University of Washington, Seattle, WA 98104, USA
    Proc Natl Acad Sci U S A 107:5995-9. 2010
    ..The data suggest that silymarin- and silymarin-derived compounds may influence HCV disease course in some patients. Studies where standardized silymarin is dosed to identify specific clinical endpoints are urgently needed...
  31. ncbi Protective effect of kombucha tea against tertiary butyl hydroperoxide induced cytotoxicity and cell death in murine hepatocytes
    Semantee Bhattacharya
    Department of Life Sciences and Biotechnology, Jadavpur University, 188 Raja S C Mullick Road, Kolkata 700 032, India
    Indian J Exp Biol 49:511-24. 2011
    ..Results of the study showed that KT has the potential to ameliorate TBHP induced oxidative insult and cell death in murine hepatocytes more effectively than BT...
  32. pmc Nrf2-mediated liver protection by sauchinone, an antioxidant lignan, from acetaminophen toxicity through the PKCδ-GSK3β pathway
    Hee Yeon Kay
    Innovative Drug Research Center for Metabolic and Inflammatory Diseases, College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Sillimdong, Kwanak gu, Seoul, Korea
    Br J Pharmacol 163:1653-65. 2011
    ..CONCLUSION AND IMPLICATIONS Our results demonstrate that sauchinone protects the liver from APAP-induced toxicity by activating Nrf2, and this effect is mediated by PKCδ activation, which induces inhibitory phosphorylation of GSK3β...
  33. ncbi Protective effects of berberine in an experimental rat osteoarthritis model
    Peng Fei Hu
    Department of Orthopaedic Surgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, PR China
    Phytother Res 25:878-85. 2011
    ..These findings suggest that berberine may play a protective role in the development of OA and may be useful in the treatment of OA...
  34. pmc The deceptive nature of UVA tanning versus the modest protective effects of UVB tanning on human skin
    Yoshinori Miyamura
    Laboratory of Cell Biology, National Cancer Institute, Bethesda, MD, USA
    Pigment Cell Melanoma Res 24:136-47. 2011
    ..Thus, UVA tanning contributes essentially no photoprotection, although all types of UV-induced tanning result in DNA and cellular damage, which can eventually lead to photocarcinogenesis...
  35. ncbi The antioxidant, rather than prooxidant, activities of quercetin on normal cells: quercetin protects mouse thymocytes from glucose oxidase-mediated apoptosis
    Jeong Chae Lee
    Division of Biological Sciences and The Research Center of Bioactive Materials, Chonbuk National University, Chonju 561 756, Korea
    Exp Cell Res 291:386-97. 2003
    ..Our findings suggest that quercetin protects mouse thymocytes from oxidative stress-mediated apoptosis and modulates the intracellular redox state through its antioxidant activity...
  36. ncbi Gut protection by palifermin during autologous haematopoietic SCT
    J E Johansson
    Department of Haematology, Sahlgrenska University Hospital, Goteborg, Sweden
    Bone Marrow Transplant 43:807-11. 2009
    ..Whether intestinal barrier preservation protects from invasive infections, and in the allogeneic setting diminishes GVHD severity, remains to be investigated in randomized controlled trials...
  37. ncbi Ribose cysteine protects against acetaminophen-induced hepatic and renal toxicity
    A M Lucas
    Department of Pharmaceutical Sciences, University of Connecticut, Storrs 06269 2092, USA
    Toxicol Pathol 28:697-704. 2000
    ..RibCys decreased both toxicity and covalent binding after APAP administration, and in addition to protecting the liver, this cysteine prodrug can also effectively protect the kidney from APAP-induced injury...
  38. pmc Prevention of hepatorenal toxicity with Sonchus asper in gentamicin treated rats
    Muhammad R Khan
    Department of Biochemistry, Faculty of Biological Sciences, Quaid i Azam University Islamabad 44000, Pakistan
    BMC Complement Altern Med 11:113. 2011
    ..We have investigated the preventive effect of methanolic extract of Sonchus asper (SAME) on the gentamicin induced alterations in biochemical and morphological parameters in liver and kidneys of Sprague-Dawley male rat...
  39. ncbi Effects of various propolis concentrations on biochemical and hematological parameters of rainbow trout (Oncorhynchus mykiss)
    Zeliha Selamoglu Talas
    Department of Biology, Faculty of Arts and Science, Nigde University, Nigde, Turkey
    Ecotoxicol Environ Saf 72:1994-8. 2009
    ..01 g/L propolis were investigated. Dose-dependent effects of propolis on blood of fish can be favorable, opening new perspectives of investigation on their biological properties and utilization...
  40. ncbi Biscuit melanoidins of different molecular masses protect human HepG2 cells against oxidative stress
    Maria Angeles Martin
    Consejo Superior de Investigaciones Cientificas, Instituto del Frio ICTAN, Jose Antonio Novais 10, Madrid, Spain
    J Agric Food Chem 57:7250-8. 2009
    ..The results show that treatment of HepG2 cells with concentrations of biscuit melanoidins within the expected physiological range confers on the cells a significant protection against an oxidative challenge...
  41. ncbi Multiple treatment of propolis extract ameliorates carbon tetrachloride induced liver injury in rats
    Monika Bhadauria
    Reproductive Biology and Toxicology Laboratory, School of Studies in Zoology, Jiwaji University, Gwalior 474 011, MP, India
    Food Chem Toxicol 46:2703-12. 2008
    ....
  42. ncbi Protective effect of interferon-alpha on carbon tetrachloride-induced nephrotoxicity
    Ayhan Dogukan
    Department of Nephrology, Firat University Medical School, Elazig, Turkey
    J Nephrol 16:81-4. 2003
    ..The aim of this study was to investigate the effect of chronic administration of interferon-alpha 2b for the prevention of carbon tetrachloride (CCl4)-induced oxidative stress and nephrotoxicity...
  43. ncbi Protective effects of quercetin against phenylhydrazine-induced vascular dysfunction and oxidative stress in rats
    Saowanee Luangaram
    Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
    Food Chem Toxicol 45:448-55. 2007
    ..These results provide the first evidence for the role of the flavonoid, quercetin, in the alleviation of vascular dysfunction in an animal model of PHZ-induced oxidant stress...
  44. ncbi Quercetin and sesamin protect neuronal PC12 cells from high-glucose-induced oxidation, nitrosative stress, and apoptosis
    Julie Bournival
    Cellular Neurobiology, Department of Biochemistry, Universite du Quebec a Trois Rivieres, Trois Rivieres, Quebec, Canada
    Rejuvenation Res 15:322-33. 2012
    ..Our results indicate a powerful role for these natural dietary compounds and emphasize preventive or complementary nutritional strategies for diabetes control...
  45. ncbi Total saponins of Panax notoginseng protected rabbit iliac artery against balloon endothelial denudation injury
    Si Wei Chen
    Department of Cardiology, the 4th Affliated Hospital of Ji nan University, Pharmacy College, Ji Nan University, Guangzhou 510632, China
    Acta Pharmacol Sin 25:1151-6. 2004
    ..To investigate whether total Panax notoginseng saponins (PNS) could protect endothelium of rabbit iliac artery against balloon endothelial denudation (BED) injury...
  46. ncbi Protective effect of omeprazole against acute gastric mucosal lesions induced by compound 48/80, a mast cell degranulator, in rats
    Takashi Kobayashi
    Department of Internal Medicine, Second Teaching Hospital, School of Medicine, Fujita Health University, Nagoya, Aichi 454 0012, Japan
    Pharmacol Res 46:75-84. 2002
    ..These results indicate that omeprazole protects against compound 48/80-induced acute gastric mucosal lesions in rats possibly through its anti-inflammatory and antioxidant actions...
  47. ncbi Protective effects of caffeic acid phenethyl ester (CAPE) on amikacin-induced nephrotoxicity in rats
    Hakan Parlakpinar
    Department of Pharmacology, Faculty of Medicine, Inonu University, Malatya, Turkey
    Cell Biochem Funct 24:363-7. 2006
    ..Morphological tubule damage in rats given AK was severe in the renal cortex, whereas in rats given AK plus CAPE, no histological changes occurred. It is concluded that CAPE could be useful for reducing the nephrotoxic effects of AK...
  48. ncbi Photoprotective effects of a formulation containing tannase-converted green tea extract against UVB-induced oxidative stress in hairless mice
    Yang Hee Hong
    Research Institute of Health and Sciences, Korea University, Seoul, Republic of Korea
    Appl Biochem Biotechnol 166:165-75. 2012
    ..05) decreases in thiobarbituric acid-reactive substance levels by lipid peroxidation compared with No UVB control mice. Our data suggest that this formulation may be effective in protecting skin from UVB photodamage...
  49. ncbi RNA as a new target for toxic and protective agents
    Carmela Fimognari
    Dipartimento di Farmacologia, Alma Mater Studiorum Universita di Bologna, Bologna, Italy
    Mutat Res 648:15-22. 2008
    ..For spermine, an alteration of the rates of spermine absorption and uptake can also be involved...
  50. ncbi Carbon tetrachloride-induced nephrotoxicity and protective effect of betaine in Sprague-Dawley rats
    Feral Ozturk
    Department of Histology Embryology, Inonu University Faculty of Medicine, Malatya, Turkey
    Urology 62:353-6. 2003
    ....
  51. ncbi Silymarin modulates the oxidant-antioxidant imbalance during diethylnitrosamine induced oxidative stress in rats
    Kannampalli Pradeep
    Department of Pharmacology and Environmental Toxicology, Dr A L M P G Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai 600113, India
    Eur J Pharmacol 560:110-6. 2007
    ..The results from the present study indicate that silymarin exhibits good hepatoprotective and antioxidant potential against diethylnitrosamine induced hepatocellular damage in rats...
  52. ncbi Cisplatin impairs antioxidant system and causes oxidation in rat kidney tissues: possible protective roles of natural antioxidant foods
    Recep Cetin
    Ankara Oncology Education and Search Hospital, Department of General Surgery, Ankara, Turkey
    J Appl Toxicol 26:42-6. 2006
    ..It is proposed that supplementation of some foods such as black grape which has resveratrol as an antioxidant can provide significant protection against cisplatin nephrotoxicity...
  53. ncbi Silymarin modulates Cisplatin-induced oxidative stress and hepatotoxicity in rats
    Heba Hosny Mansour
    Health Radiation Research Department, National Center for Radiation Research and Technology, Cairo, Egypt
    J Biochem Mol Biol 39:656-61. 2006
    ..The results obtained suggested that silymarin significantly attenuated the hepatotoxicity as an indirect target of CDDP in an animal model of CDDP-induced nephrotoxicity...
  54. pmc Protective effects of Spirulina maxima on hyperlipidemia and oxidative-stress induced by lead acetate in the liver and kidney
    Johny C Ponce-Canchihuamán
    Departamento de Bioquimica, Facultad de Medicina, Universidad Nacional Autonoma de Mexico, Mexico, D F, Mexico
    Lipids Health Dis 9:35. 2010
    ....
  55. ncbi Synchronized and sustained release of multiple components in silymarin from erodible glyceryl monostearate matrix system
    Cheng Lu
    School of Pharmacy, Fudan University, Shanghai, PR China
    Eur J Pharm Biopharm 66:210-9. 2007
    ..In vitro hemolysis study indicated that the synchronized release samples showed a much better stabilizing effect on erythrocyte membrane...
  56. ncbi Preparation of silymarin proliposome: a new way to increase oral bioavailability of silymarin in beagle dogs
    Xiao Yan-yu
    Department of Pharmacy, China Pharmaceutical University, Nanjing 210009, PR China
    Int J Pharm 319:162-8. 2006
    ..21 and 697 ng mL(-1)h, respectively. The high bioavailability of silymarin proliposome could be obtained by oral administration. Silymarin proliposome was stable and did enchance the gastrointestinal absorption of silymarin...
  57. ncbi Protective effects of combined micronutrients on islet beta-cells of streptozotocin-induced diabetic mice
    Ying Chang
    Department of Central Research, The Third Clinical College, Jilin University, Xiantai Street No 126, Changchun 130033, China
    Int J Vitam Nutr Res 79:104-16. 2009
    ....
  58. ncbi Antioxidant and hepatoprotective effects of Ginkgo biloba phytosomes in carbon tetrachloride-induced liver injury in rodents
    Suresh R Naik
    Sinhgad Institute of Pharmaceutical Sciences, Lonavala, India
    Liver Int 27:393-9. 2007
    ..The protective effects of Ginkgo biloba phytosomes (GBP) on carbon tetrachloride (CCl4)-induced hepatotoxicity and the probable mechanism(s) involved in this protection were investigated in rats...
  59. ncbi Hepatoprotective effects of Coptidis rhizoma aqueous extract on carbon tetrachloride-induced acute liver hepatotoxicity in rats
    Xingshen Ye
    School of Chinese Medicine, The University of Hong Kong, 10 Sassoon Road, Pokfulam, PR China
    J Ethnopharmacol 124:130-6. 2009
    ..To clarify this ethnopharmacological relevance, hepatoprotective effect of Coptidis rhizoma aqueous extract (CRAE) and its possible mechanism were studied in rats intoxicated with carbon tetrachloride (CCl4) in the present study...
  60. ncbi Treatment of silymarin, a plant flavonoid, prevents ultraviolet light-induced immune suppression and oxidative stress in mouse skin
    Santosh K Katiyar
    Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL 35294 0019, USA
    Int J Oncol 21:1213-22. 2002
    ....
  61. ncbi Protective role of tauroursodeoxycholate during harvesting and cold storage of human liver: a pilot study in transplant recipients
    L Falasca
    Department of Surgery, University of Rome Tor Vergata, Italy
    Transplantation 71:1268-76. 2001
    ..CONCLUSIONS: The use of TUDCA during harvesting and cold storage of human liver is associated with significant protection from ischemia-reperfusion injury. The clinical significance of this findings must be studied...
  62. ncbi Schisandrin B protects against tert-butylhydroperoxide induced cerebral toxicity by enhancing glutathione antioxidant status in mouse brain
    Kam Ming Ko
    Department of Biochemistry, The Hong Kong University of Science and Technology, Clear Water Bay, China
    Mol Cell Biochem 238:181-6. 2002
    ..The ensemble of results suggests the antioxidant potential of Sch B pretreatment in protecting against cerebral oxidative stress...
  63. ncbi BNP7787, a novel protector against platinum-related toxicities, does not affect the efficacy of cisplatin or carboplatin in human tumour xenografts
    E Boven
    Department of Medical Oncology, Vrije Universiteit Medical Centre, De Boelelaan 1117, Amsterdam, The Netherlands
    Eur J Cancer 38:1148-56. 2002
    ..We can conclude that BNP7787 does not interfere with the antitumour activity of platinum compounds in vitro and in vivo. Clinical trials are underway to evaluate the protection of normal tissues by BNP7787 when combined with cisplatin...
  64. ncbi Mechanisms of fenretinide-induced apoptosis
    N Hail
    Department of Clinical Pharmacy, School of Pharmacy, The University of Colorado at Denver and Health Sciences Center, Box C238, 80262, USA
    Apoptosis 11:1677-94. 2006
    ....
  65. ncbi Renoprotective effect of erdosteine in rats against gentamicin nephrotoxicity: a comparison of 99mTc-DMSA uptake with biochemical studies
    Mehmet Cabuk
    Department of Nuclear Medicine, Faculty of Medicine, Zonguldak Karaelmas University, 67600 Kozlu, 44069 Zonguldak, Turkey
    Mol Cell Biochem 308:35-42. 2008
    ..In conclusion, our results supported a protective role of Erdosteine in nephrotoxicity associated with GM treatment...
  66. ncbi LPS from Escherichia coli protects against indomethacin-induced gastropathy in rats--role of ATP-sensitive potassium channels
    Antoniella S Gomes
    Department of Physiology and Pharmacology, Federal University of Ceará Brazil, Brazil
    Eur J Pharmacol 547:136-42. 2006
    ..Glibenclamide plus diazoxide administration did not change this LPS effect. Thus LPS has a protective effect against indomethacin-induced gastropathy, probably through activation of K(ATP) channels...
  67. ncbi Silymarin protects dopaminergic neurons against lipopolysaccharide-induced neurotoxicity by inhibiting microglia activation
    Mei Jen Wang
    Department of Education and Research, Taichung Veterans General Hospital, Taichung 40705, Taiwan
    Eur J Neurosci 16:2103-12. 2002
    ..It suggests that the inhibitory effect of silymarin on microglia activation is mediated through the inhibition of NF-kappaB activation...
  68. ncbi Mesna: a novel renoprotective antioxidant in ischaemic acute renal failure
    E Mashiach
    Eliachar Research Laboratory, Nephrology Unit and Pathology Department, Western Galilee Hospital, Nahariya, Israel
    Nephrol Dial Transplant 16:542-51. 2001
    ....
  69. ncbi Preclinical studies with adrenomedullin and its binding protein as cardiovascular protective agents for hemorrhagic shock
    Rongqian Wu
    Department of Surgery, North Shore University Hospital and Long Island Jewish Medical Center, Manhasset, NY, USA
    Cardiovasc Drug Rev 24:204-13. 2006
    ..Thus, administration of AM/AMBP-1 appears to be a novel and useful approach for restoring cardiovascular responses, preventing organ injury, and reducing mortality after hemorrhagic shock...
  70. ncbi Fungal siderophores function as protective agents of LDL oxidation and are promising anti-atherosclerotic metabolites in functional food
    Istvan Pocsi
    Department of Microbial Biotechnology and Cell Biology, Faculty of Science and Technology, University of Debrecen, Debrecen, Hungary
    Mol Nutr Food Res 52:1434-47. 2008
    ..The consumption of mold-ripened food products such as aged cheeses and the introduction of functional foods and food additives rich in fungal iron chelators in diets may lower the risk of cardiovascular diseases...
  71. ncbi Roles of nitric oxide in protective effect of berberine in ethanol-induced gastric ulcer mice
    Long rui Pan
    Department of Pharmacology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Acta Pharmacol Sin 26:1334-8. 2005
    ..To investigate the protective effects of berberine on ethanol-induced gastric ulcer in mice...
  72. ncbi Structure-modifying agents for osteoarthritis: an update
    Pascal Richette
    Federation de rhumatologie, Lariboisière Teaching Hospital, 2 rue Ambroise Pare, 75010 Paris cedex 10, France
    Joint Bone Spine 71:18-23. 2004
    ..Although most of these agents have shown promising effects in vitro, none has been proven to produce clinically meaningful structure-modifying effects in humans with osteoarthritis...
  73. ncbi Protective agents used to reverse the metabolic changes induced in wine yeasts by concomitant osmotic and thermal stress
    A Caridi
    Department of Agro Forestry and Environmental Technology and Sciences, Mediterranean University of Reggio Calabria, Gallina RC, Italy
    Lett Appl Microbiol 35:98-101. 2002
    ..The reversion of the metabolic changes induced in wine yeasts by stressors...
  74. ncbi [Inhibitory effects of silymarin on hepatic fibrosis induced by dimethylnitrosamine: experiment with rats]
    Xin Yan Zhao
    Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China
    Zhonghua Yi Xue Za Zhi 86:2563-6. 2006
    ..To investigate the antifibrotic effects of silymarin on hepatic fibrosis...
  75. ncbi Taurine protects acetaminophen-induced oxidative damage in mice kidney through APAP urinary excretion and CYP2E1 inactivation
    Joydeep Das
    Division of Molecular Medicine, Bose Institute, P 1 12, CIT Scheme VII M, Kolkata 700054, West Bengal, India
    Toxicology 269:24-34. 2010
    ..Results suggest that taurine might be a potential therapeutic candidate against APAP-induced acute nephrotoxicity...
  76. ncbi Cellular mechanisms of the protective effect of polyphenols on the neurovascular unit in strokes
    Y Curin
    Laboratoire de Pharmacochimie de la Communication Moléculaire, UMR 7081 CNRS, Faculte de Pharmacie, Illkirch, France
    Cardiovasc Hematol Agents Med Chem 4:277-88. 2006
    ..In this review, we focus on the beneficial effects of polyphenols on the complex pathophysiological events of stroke and helpful indications for the design of an effective and well-tolerated therapy will be discussed...
  77. ncbi Quercetin, coenzyme Q10, and L-canavanine as protective agents against lipid peroxidation and nitric oxide generation in endotoxin-induced shock in rat brain
    H M Abd El-Gawad
    Department of Biochemistry, Faculty of Pharmacy, Cairo University, Cairo, Egypt
    Pharmacol Res 43:257-63. 2001
    ..In conclusion, this study indicates that SOD may not reflect the level of peroxidation and points to the value of quercetin, CoQ10, and L-canavanine in ameliorating the oxidative status of brain during the early phase of endotoxic shock...
  78. ncbi The dark side of light: the damaging effects of UV rays and the protective efforts of MAP kinase signaling in the epidermis
    Jeffrey Hildesheim
    Gene Response Section, Center for Cancer Research, NCI, NIH, Building 37, Room 6144, 37 Convent Drive, Bethesda, MD 20892, USA
    DNA Repair (Amst) 3:567-80. 2004
  79. ncbi Fluorinated amphiphilic amino acid derivatives as antioxidant carriers: a new class of protective agents
    Stéphanie Ortial
    Laboratoire de Chimie Bioorganique et des Systèmes Moléculaires Vectoriels, Faculte des Sciences, Universite d Avignon et des Pays de Vaucluse, 84000 Avignon, France
    J Med Chem 49:2812-20. 2006
    ..The findings demonstrated herein therefore strongly suggest that the amphiphilic character enhances the bioavailability of the antioxidants and allows for a selective targeting of mitochondria...
  80. ncbi Simultaneous determination of BNP7787 and its metabolite mesna in plasma and tissue by micro-HPLC with a dual electrochemical detector
    Miranda Verschraagen
    Department of Medical Oncology, Vrije Universiteit Medical Center, KRIGO, BR 232 De Boelelaan 1117, 1007 MB Amsterdam, The Netherlands
    J Pharm Sci 92:1040-50. 2003
    ..4 g/m(2) BNP7787 as a 15-min intravenous infusion...
  81. ncbi Mechanism of protective action of bicyclol against CCl-induced liver injury in mice
    Geng Tao Liu
    Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    Liver Int 25:872-9. 2005
    ..These results suggest that bicyclol has remarkable hepatoprotective effects and its mechanism of action may be related to a decrease in free radical-induced damage to hepatocytes...
  82. ncbi Protective effect of (S)-bakuchiol from Psoralea corylifolia on rat liver injury in vitro and in vivo
    Eun Jeon Park
    Department of Pharmacy, Wonkwang University, Iksan, Jeonbuk, Republic of Korea
    Planta Med 71:508-13. 2005
    ..From these results, bakuchiol has a protective effect against tBH, CCl4 or D-GalN-induced hepatotoxicity in vitro or in vivo...
  83. ncbi The protective effects of Hibiscus sabdariffa extract on CCl4-induced liver fibrosis in rats
    Jer Yuh Liu
    Institute of Biochemistry and Biotechnology, College of Medicine, Chung Shan Medical University, Taichung, Taiwan
    Food Chem Toxicol 44:336-43. 2006
    ..These results suggested that HSE may protect the liver against CCl(4)-induced fibrosis. This protective effect appears due to HSEs antioxidant properties...
  84. ncbi Hepatoprotective effects of Nigella sativa L and Urtica dioica L on lipid peroxidation, antioxidant enzyme systems and liver enzymes in carbon tetrachloride-treated rats
    Mehmet Kanter
    Department of Histology and Embryology, Faculty of Medicine, Trakya University, Edirne, Turkey
    World J Gastroenterol 11:6684-8. 2005
    ..To investigate the effects of Nigella sativa L (NS) and Urtica dioica L (UD) on lipid peroxidation, antioxidant enzyme systems and liver enzymes in CCl(4)-treated rats...
  85. ncbi Hepatoprotective studies on Hedyotis corymbosa (L.) Lam
    Sini Sadasivan
    Department of Biotechnology, Karpagam Arts and Science College, Coimbatore 641 021, India
    J Ethnopharmacol 106:245-9. 2006
    ..Hedyotis corymbosa shortened hexobarbitone-induced sleeping time in mice, besides showing significant antilipid peroxidant effect in vitro. The results thus support the use of Hedyotis corymbosa as a hepatoprotective agent...
  86. ncbi The hepatoprotective action of ten herbal extracts in CCl4 intoxicated liver
    M A Rusu
    Institute of Biological Research, Cluj Napoca, Romania
    Phytother Res 19:744-9. 2005
    ....
  87. ncbi Hepatoprotective activity of Leucas hirta against CCl4 induced hepatic damage in rats
    B K Manjunatha
    Department of Botany, S R N M N College of Applied Sciences, Shimoga 577 201, India
    Indian J Exp Biol 43:722-7. 2005
    ..The results revealed that methanol leaf extract followed by aqueous extract of L. hirta could afford significant protection against CCl4 induced hepatocellular injury...
  88. ncbi Opuntia ficus indica (L.) Mill. fruit juice protects liver from carbon tetrachloride-induced injury
    E M Galati
    Pharmaco Biological Department, School of Pharmacy, University of Messina, Vill SS Annunziata, Italy
    Phytother Res 19:796-800. 2005
    ..Hepatoprotection may be related to the flavonoid fraction of the juice, but other compounds, such as vitamin C and betalains could, synergistically, counteract many degenerative processes by means of their antioxidant activity...
  89. ncbi Aqueous extract of Anoectochilus formosanus attenuate hepatic fibrosis induced by carbon tetrachloride in rats
    C C Shih
    Graduate Institute of Chinese Pharmaceutical Sciences, China Medical University, 91 Hsueh Shih Road, Taichung, Taiwan
    Phytomedicine 12:453-60. 2005
    ..AFE significantly increased liver glutathione concentrations. All these results clearly demonstrate that AFE can reduce the liver fibrogensis in rats induced by CCl4...
  90. ncbi The protective effects of Phyllanthus emblica Linn. extract on ethanol induced rat hepatic injury
    Pornpen Pramyothin
    Pharmacological Action of Natural Products Research Unit, Department of Pharmacology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand
    J Ethnopharmacol 107:361-4. 2006
    ..o.) enhanced liver cell recovery by bringing the levels of AST, ALT, IL-1beta back to normal. Histopathological studies confirmed the beneficial roles of PE and SL against ethanol induced liver injury in rats...
  91. ncbi Hepatoprotective activity of the Leucas lavandulaefolia on D(+)galactosamine-induced hepatic injury in rats
    K S Chandrashekar
    Department of Pharmacognosy, NGSM Institute of Pharmaceutical Sciences, Nanthoor, Mangalore, India
    Fitoterapia 78:440-2. 2007
    ..Silymarin (25 mg/kg), a known hepatoprotective drug used as a standard also exhibited a significant activity...
  92. ncbi Evaluation of hepatoprotective activity of Clerodendrum serratum L
    S M Vidya
    Department of Biotechnology, S R N M N College of Applied Sciences, Shimoga 577 201, India
    Indian J Exp Biol 45:538-42. 2007
    ..The results when compared with the standard drug silymarin, revealed that the hepatoprotective activity of the constituent ursolic acid is significant as similar to the standard drug...
  93. ncbi Hepatoprotective activity of Calotropis procera flowers against paracetamol-induced hepatic injury in rats
    S Ramachandra Setty
    Department of Pharmacology, S C S College of Pharmacy, Davanagere, Karnataka, India
    Fitoterapia 78:451-4. 2007
    ..Treatment with hydro-ethanolic extract of C. procera flowers (200 mg/kg and 400 mg/kg) has brought back the altered levels of biochemical markers to the near normal levels in the dose dependent manner...
  94. ncbi Hepatoprotective activity of chitosan against isoniazid and rifampicin-induced toxicity in experimental rats
    Sethumadhavan Santhosh
    Fish Processing Division, Central Institute of Fisheries Technology, Cochin 682029, India
    Eur J Pharmacol 572:69-73. 2007
    ..Levels of glycoconjugates were also maintained to near normal level by chitosan co-administration. From the results obtained, it can be concluded that chitosan is beneficial against antitubercualr drugs-induced hepatoxicity...
  95. ncbi Phytochemical investigation and hepatoprotective activity of Cupressus sempervirens L. leaves growing in Egypt
    Nabaweya Ali Ibrahim
    National Research Center, Pharmacognosy Department, Dokki, Cairo, Egypt
    Nat Prod Res 21:857-66. 2007
    ....
  96. ncbi The potential protective role of alpha-lipoic acid against acetaminophen-induced hepatic and renal damage
    Ahmed O Abdel-Zaher
    Department of Pharmacolog, Faculty of Medicine, Assiut University, Assiut, Egypt
    Toxicology 243:261-70. 2008
    ..These results provide evidence that inhibition of NO overproduction and maintenance of intracellular antioxidant status may play a pivotal role in the protective effects of alpha-LA against APAP-induced hepatic and renal damage...
  97. ncbi Moringa oleifera Lam prevents acetaminophen induced liver injury through restoration of glutathione level
    S Fakurazi
    Pharmacology Unit, Department of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia
    Food Chem Toxicol 46:2611-5. 2008
    ..The histological hepatocellular deterioration was also evidenced. The results from the present study suggested that the leaves of MO can prevent hepatic injuries from APAP induced through preventing the decline of glutathione level...
  98. ncbi Hepatoprotective potentials of Phyllanthusamarus against ethanol-induced oxidative stress in rats
    Toyin Y Faremi
    Department of Biochemistry, Faculty of Basic Medical Sciences, College of Medicine, University of Ibadan, Ibadan, Nigeria
    Food Chem Toxicol 46:2658-64. 2008
    ..amarus co-treatment. Results show that P. amarus leaf extract could protect the liver against ethanol-induced oxidative damage by possibly reducing the rate of lipid peroxidation and increasing the antioxidant defence mechanism in rats...
  99. ncbi Hepatoprotective effect of the ethyl acetate extract of Teucrium polium L. against carbontetrachloride-induced hepatic injury in rats
    Tatjana Kadifkova Panovska
    Institute of Toxicology Faculty of Pharmacy, University Ss Cyril and Methodius, 1000 Skopje, Republic of Macedonia
    Acta Pharm 57:241-8. 2007
    ..The study substantiates the potential hepatoprotective activity of the ethyl acetate extract of Teucrium polium L...
  100. ncbi Identification and properties of 2,5-dihydroxy-4,3'-di(beta-D-glucopyranosyloxy)-trans-stilbene from Morus bombycis Koidzumi roots
    Ying Shan Jin
    School of Biotechnology, Kangwon National University, Chuncheon, Kangwon Do, 200 701, South Korea
    Phytother Res 21:605-8. 2007
    ..These results demonstrate that the 2,5-dihydroxy-4,3'-di(beta-d-glucopyranosyloxy)-trans-stilbene component has a liver protective action against CCl4-induced hepatotoxicity...
  101. ncbi Antioxidant and hepatoprotective actions of medicinal herb, Terminalia catappa L. from Okinawa Island and its tannin corilagin
    S Kinoshita
    Laboratory of Functional and Molecular Pharmacology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903 0215, Japan
    Phytomedicine 14:755-62. 2007
    ..These results show that the extract of T. catappa and its antioxidant, corilagin are protective against GalN/LPS-induced liver injury through suppression of oxidative stress and apoptosis...

Research Grants62

  1. Molecular Mechanisms of Chemoprevention: NRF2 Signaling
    Thomas W Kensler; Fiscal Year: 2013
    ..Collectively, these studies will further the goal of effectively using activators of Nrf2 signaling as protective agents in human populations exposed to environmental toxicants...
  2. The function of ATM protein in the biology of the adult neuron CNS:
    Karl Herrup; Fiscal Year: 2013
    ..for their response to stress and compare anti-oxidant and anti-inflammatory strategies for the potency as protective agents. Successful leads will be followed by in vivo trials comparing wild type with two different Atm mutations ..
  3. Analyzing Anthrax Toxins in Drosophilia
    Ethan Bier; Fiscal Year: 2013
    ..Finally, in Aim 2.2, we will determine whether increasing Rab11 levels or treating with known barrier protective agents can reverse the vascular leakage caused by EF...
  4. Detoxification of Electrophilic Chemical Threat Agents by Nucleophilic Scavengers
    Michael C MacLeod; Fiscal Year: 2010
    ..We will use a combined in vitro/in vivo approach to determine the efficacy of two groups of potential protective agents: nucleophilic scavenging agents and agents that enhance endogenous conjugation reactions, particularly the ..
  5. Nanoliposome-based Treatment of Amyloid Protein (AL) Toxicity
    RAYMOND QUEZON MIGRINO; Fiscal Year: 2013
    ..developing and testing nanoliposomes alone (unconjugated) or functionalized with clusterin (conjugated) as protective agents against LC-induced toxicity to human vascular tissue...
  6. Mitochondrial Iron-Sulfur cluster mechanisms and therapy in Friedreich's ataxia
    Gino A Cortopassi; Fiscal Year: 2013
    ..abstract_text> ..
  7. Neuroprotective agents for retinal diseases
    CHRIS LINDSEY; Fiscal Year: 2012
    ..Two mito-protective agents viewed as potential neuroprotectants (compounds CB11 and CB12) tested positive on intact retinas from rd1 ..
  8. Microtubule-associated Rac
    Anna Birukova; Fiscal Year: 2013
    ..In contrast, effects of barrier-protective agents on crosstalk between MT, cell adhesions, and actin cytoskeleton are not clear, nor the role of MT changes in ..
  9. Protection of Mice From Lethal Alphavirus Encephalitis
    David N Irani; Fiscal Year: 2010
    ..other anti-inflammatory agents known to target microglia in our model, and to verify the effects of all our protective agents against other New World alphaviruses that cause fatal encephalitis in humans, (2) To investigate ..
  10. Adverse Effects of Noise on Hearing: Basic Mechanisms
    Barbara A Bohne; Fiscal Year: 2010
    ..The lack of knowledge about mechanisms of noise-induced hair-cell death has hindered identification of noise-protective agents. We recently discovered that some dying outer hair cells (OHCs) in noise-exposed cochleae have morphological ..
  11. Combinational Approaches to the Chemoprevention of Esophageal Cancer
    Tong Chen; Fiscal Year: 2012
    ..There is an urgent need to identify protective agents, which can prevent this disease in the individuals associated with increasing esophageal cancer risk...
  12. Mechanisms of Prostacyclin-Mediated Lung Endothelial Barrier Protection
    Konstantin Birukov; Fiscal Year: 2013
    ..Many experimental models for testing of novel protective agents utilize preventive or concurrent treatment during ALI induction, while post-treatment represents more ..
  13. Delivery of passive immunity against HIV using commensal vaginal Lactobacillus bi
    Laurel A Lagenaur; Fiscal Year: 2012
    ..Osel, Inc. and Profectus BioSciences are collaborating to exploit the properties of these natural protective agents by engineering a native human vaginal Lactobacillus, L...
  14. Brain metabolism and neuroprotection in cardiopulmonary bypass
    Anna Pastuszko; Fiscal Year: 2012
    ..brain injury by the surgical procedures, and critically evaluate mild hypothermia as well as two promising protective agents, Granulocyte Colony-Stimulating Factor (GCSF) and Topiramate both alone and together, for their efficacy in ..
  15. HIV/COCAINE NEUROTOXICITY IN FEMALES
    Rosemarie M Booze; Fiscal Year: 2013
    ..In this competing renewal application, we will explore the hypothesis that estrogenic compounds may serve as protective agents for the synergistic effects of cocaine/HIV proteins on producing synaptic impairments in the nucleus ..
  16. Chemoprotection Against Aminoglycoside-Induced Ototoxicity
    Julian A Simon; Fiscal Year: 2013
    ..These convergent and complementary studies will aid in the development of target-based hair cell protective agents and expand the molecular understanding of AGA-induced cell damage...
  17. Drug-induced Protection from Acoustic Trauma
    Joe C Adams; Fiscal Year: 2012
    ..This project will study tissue defense mechanisms to better understand how the ear can be protected from noise damage and how future treatments can be optimized to better prevent and minimize noise-induced hearing loss. ..
  18. Next-generation Fluorescent Probes for Biological Research
    Scott C Blanchard; Fiscal Year: 2013
    ..Moreover, the benefits of adding protective agents must be empirically determined for each system investigated and their mechanisms of action are not fully ..
  19. Cardiomyocyte mitochondria and mtROS in cardiac aging, hypertrophy and failure
    Peter S Rabinovitch; Fiscal Year: 2013
    ..This comprehensive approach will provide an integrated assessment of the role of mitochondria in cardiac health, disease and disease-resistance. (End of Abstract) ..
  20. Mitochondrial Antioxidants, Aging and Healthspan
    Peter S Rabinovitch; Fiscal Year: 2013
    ..abstract_text> ..
  21. Health Effects of CREON2000 In Asthmatic Children
    Mark Glazman; Fiscal Year: 2003
    ..g., endotoxin) have the potential to act as protective agents versus allergens capable of sensitizing and causing allergies and asthma...
  22. FISH OILS AND LIPOPROTEIN METABOLISM
    William Harris; Fiscal Year: 1992
    ..populations has led to the hypothesis that fish oils containing omega-3 fatty acids (w3 FA) may be protective agents. Clinical studies have shown that high intakes of fish oils cause total cholesterol and, particularly, ..
  23. PEROXYNITRITE AS MYOCARDIAL PROTECTIVE AGENTS
    Laszlo Virag; Fiscal Year: 2000
    ..PROPOSED COMMERCIAL APPLICATIONS: The annual anticipated revenue for an effective therapeutic to prevent and treat myocardial repertusion injury is estimated at> $1 billion in the US per annum. ..
  24. Immune aspects of mTOR inhibition for cancer prevention (PQ5)
    Tyler J Curiel; Fiscal Year: 2013
    ..in a well-defined carcinogen-induced skin cancer model in which T cells and IFN-[unreadable] are important protective agents and in which mTOR inhibition prevents cancer...
  25. Variations in plasma phytoestrogen levels in Europe
    Petra Peeters; Fiscal Year: 2004
    Phytoestrogens, widespread plant compounds, have been proposed as protective agents against hormone dependent cancers in humans, but results from human studies are inconclusive...
  26. MACULAR BIOCHEMISTRY
    ALICE ADLER; Fiscal Year: 1999
    ..in its unusual anatomy but also in its biochemistry, particularly in the detailed spatial distributions of protective agents. A secondary hypothesis that active biochemical proc~ may be responsible for the specific patterns displayed ..
  27. COGNITION, STEROIDS AND IMAGING IN CUSHINGS DISEASE
    MONICA STARKMAN; Fiscal Year: 2001
    ..The rationale for developing protective drugs such as site-specific glucocorticoid receptor antagonists or excitatory amino acid suppressors would be strengthened. ..
  28. SAR INVESTIGATION OF THE NMDA-PCP-GLYCINE PHARMACOPHORE
    ANITA LEWIN; Fiscal Year: 1992
    ..This will result in the development of therapeutic and/or protective agents for the neurotoxic actions of glutamate.
  29. Radioprotection by use of Topical Lithium Formulations
    Dennis Hallahan; Fiscal Year: 2009
    ..Inhibitors of GSK-32 pathway can serve as radiation protective agents. Lithium can inhibit the GSK-32 pathway...
  30. OLIGOSACCHARIDE TECHNOLOGY TO PREVENT SKIN CANCER
    TODD WALLER; Fiscal Year: 1999
    ..is structurally incapable of producing materials to rigorous standards required to preserve the immune protective agents in Aloe...
  31. MICELLAR CARRIERS FOR SPARINGLY SOLUBLE PHARMACEUTICALS
    Vladimir Torchilin; Fiscal Year: 2002
    ..drug delivery system should definitely benefit from: 1) properties of PEO or similar polymers as steric protective agents for particulate; 2) extreme stability of diacyllipid-PEO and similar micelles; 3) smaller size compared to ..
  32. Combined Hypothermia and Neuroprotectants Extend Their Usefulness and Efficacy
    JOHN POVLISHOCK; Fiscal Year: 2009
    ..not only enhanced brain and vascular protection but also extends the therapeutic window over which other protective agents can be used with enhanced efficacy...
  33. A Novel Approach to Nerve-Sparing Prostate Cryosurgery
    KRISTI SNYDER; Fiscal Year: 2007
    ..1) NeuprosolTM will be applied directly to the NVB at the time of the cryosurgical application; (2) The protective agents will be designed through molecular analysis to be nerve cell specific; (3) The agents will also be developed ..
  34. PROTECTIVE EFFECTS OF GARLIC DERIVATIVES IN LUNG
    Poh Gek Forkert; Fiscal Year: 1999
    Garlic constituents including diallyl sulfone (DAS02) have been identified as potential protective agents, but the basis for the effects ar poorly understood, especially in the lung, a tissue that is susceptible to chemically-induced ..
  35. Functional synergism in prevention of hormone refractory CaP by phytochemicals
    Joseph Wu; Fiscal Year: 2007
    ..The identity of HRPC protective agents is ill defined and their mechanism remains to be elucidated...
  36. Alcohol Mediated Blood Brain Barrier Dysfunction
    Monique F Stins; Fiscal Year: 2010
    ..In this exploratory study, we propose to use and in vitro model of the human BBB and an in vivo mouse model for alcohol use to further investigate the mechanisms whereby alcohol affects the BBB. ..
  37. IRON-MEDIATED CARDIOVASCULAR INJURY
    LAWRENCE HORWITZ; Fiscal Year: 2006
    ..that the lipid-solubility of exochelins accounts for their potency as anti-proliferative and cardio-protective agents because of site-specific iron chelation in the lipid portions of the cell membrane...
  38. ENHANCED GLYCOLYSIS FOR HYPOTHERMIC HEART PRESERVATION
    Sufan Chien; Fiscal Year: 2003
    ..These glycolytic modulators might produce a synergistic effect and serve potentially as effective tissue-protective agents during ischemia, not only in heart preservation and cardioplegia, but also in other ischemic conditions, ..
  39. INHALATION ANESTHETIC HEPATOTOXICITY
    BURNELL BROWN; Fiscal Year: 1992
    ..therapeutic agents will be tested in the model systems, including specific biotransformation inhibitors and protective agents. Considerable emphasis will be placed on determining the metabolic pathways for these anesthetics because ..
  40. REDUCTION OF INFARCT SIZE AFTER SURGICAL REPURFUSION
    Lawrence Cohn; Fiscal Year: 1990
    ..In addition we intend to explore the use of other protective agents, particularly the oxygenated cardioplegic compounds applied distal to the site of coronary artery occlusion ..
  41. Nucleoside Transporters: Pharmacology of hENT3 and hCNT3
    Chung Ming Tse; Fiscal Year: 2007
    ..analogue drugs for the treatment of various viral, parasitic, and neoplastic diseases and as cardiovascular protective agents. The identification of hENT3 as a Golgi nucleoside transporter opens a new venue for studying molecular ..
  42. Novel Approach for Fast and Economic Manufacturing of Human Antibodies
    ALEXEY ZDANOVSKY; Fiscal Year: 2009
    ..depends on the existence of corresponding vaccines and cannot be used for expedient development of protective agents against newly emerging infections...
  43. REGIONAL CHEMOTHERAPY OF LIVER METASTASIS--COLON CANCER
    Joseph Bertino; Fiscal Year: 1991
    ..Project II); and a rat model system for assessing toxicity and response to chemotherapeutic agents and protective agents (Project III)...
  44. COENZYME Q10 IN EARLY PARKINSONS DISEASE
    Clifford Shults; Fiscal Year: 2000
    ..Also, efficient designs of clinical trials to explore the maximally tolerated dose and efficacy of potential protective agents have not been adequately explored...
  45. Carbonyl scavengers for skin protection from glycation
    ELAINE JACOBSON; Fiscal Year: 2003
    ..application provides the technical basis for the commercial development of glycation inhibitors as novel protective agents against pathological skin conditions characterized by increased glycation damage...
  46. MMP-7 and SNARE Cleavage in Neuroinflammation
    Katherine Conant; Fiscal Year: 2009
    ..The relevance of this research to Public Health is that it may explain how inflammation contributes to neurological dysfunction. Excess levels of select proteases may be considered as novel targets for neuro-protective drugs. ..
  47. ORGAN CULTURE TECHNOLOGY FOR IN VITRO TOXICOLOGY
    RICHARD SPALL; Fiscal Year: 1991
    ..They would be cultured in media that also contain protective agents (antioxidants and free radical scavengers)...
  48. Mitochondrial PKC epsilon in cardiac protection
    Jun Zhang; Fiscal Year: 2006
    ..2) To determine whether ANT1, an essential element of the MPT pore, is a downstream molecular target of PKC( and to identify the specific amino acid residues of ANT1 phosphorylated by PKCe during NO-induced cardiac protection. ..
  49. MERCAPTOETHYLGUANIDINE AND SICKLE CELL DISEASE
    Robert Stachlewitz; Fiscal Year: 1999
    ..oxide and (2) scavengers of peroxynitrite, a reactive, toxic oxidant produced in reperfusion injury and (3) protective agents in rodent experimental models of sickle cell disease...
  50. MICELLES AS PROTECTIVE AGENTS FOR HEME COMPLEXES
    JACK EMERT; Fiscal Year: 1980
    ..The effect of hydrophobic environment on the stability of heme complexes toward oxygen will be examined in order to clarify the nature of protein-heme interactions in oxygen-carrying proteins. ..
  51. HIV/COCAINE NEUROTOXICITY IN FEMALES
    Rosemarie Booze; Fiscal Year: 2005
    ..cocaine predisposing females to HIV-induced neurotoxicity? The hypothesis is: Estrogens will act as protective agents for the combined effects of repeated IV cocaine administration and gp120/Tat neurotoxicity...
  52. MODULATION OF ORGAN SPECIFIC ANTICANCER DRUG
    Miles Hacker; Fiscal Year: 1991
    ..us to develop pharmacological means of intervention-- either through analog development or use of of cardiac protective agents. 2) The mechanism of DDP induced nephrotoxicity is not understood...
  53. PROSTAGLANDINS AND GASTROINTESTINAL INTEGRITY
    Thomas Miller; Fiscal Year: 2006
    ..integrity through intracellular calcium stabilization may be a fundamental mechanism by which PGs (and other protective agents) mediate their cellular protective action, and provides a unifying hypothesis to explain the underpinnings ..
  54. BIOMONITORING AND SUSCEPTIBILITY MARKERS IN HUMAN CANCER
    Helmut Bartsch; Fiscal Year: 1991
    ..and unknown exposures; c) identification of high risk groups and subjects and, d) assessment of cancer protective agents and efficacy of intervention trials...
  55. PHARMACOKINETICS AND FETAL EXPOSURE TO NARCOTICS
    Hazel Szeto; Fiscal Year: 2002
    ..The proposed studies will provide new information on the functional roles of opiate receptor subtypes in the fetus, and should be helpful in the design of better analgesics for perinatal use. ..
  56. Neuroprotection by PACAP in Stroke
    Akira Arimura; Fiscal Year: 2003
    ..abstract_text> ..
  57. INHIBITION OF CARCINOGENESIS BY TEA AND TEA CONSTITUENTS
    Chung Yang; Fiscal Year: 2005
    ..Jointly, we intend to make major contributions to the use of tea for the I chemoprevention of cancer. ..
  58. PARS and peroxynitrite induced cell death
    Csaba Szabo; Fiscal Year: 2009
    ..4 To establish the role of Bel family proteins in the regulation of calcium homeostasis during peroxynitrite-induced cell death. The studies proposed here have broad pathophysiological relevance. ..
  59. Effect of Drugs on Myocardial Hypoxia
    Garrett Gross; Fiscal Year: 2009
    ..Information gained from these studies will hopefully lead to new therapies to treat patients with ischemic heart disease. ..
  60. Imbalancing DNA BER to enhance Ovarian Tumor Sensitivity
    Mark Kelley; Fiscal Year: 2008
    ..abstract_text> ..