poisons

Summary

Summary: Substances which, when ingested, inhaled, or absorbed, or when applied to, injected into, or developed within the body in relatively small amounts may, by their chemical action, cause damage to structure or disturbance of function. (From Dorland, 27th ed)

Top Publications

  1. ncbi Chromosome instability in human hepatocellular carcinoma depends on p53 status and aflatoxin exposure
    Pascal Pineau
    Unité d Organisation Nucléaire et Oncogénèse, INSERM U579, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France
    Mutat Res 653:6-13. 2008
  2. pmc Rac1 protein signaling is required for DNA damage response stimulated by topoisomerase II poisons
    Stefanie C Huelsenbeck
    Institute of Toxicology, Heinrich Heine University Dusseldorf, Moorenstrasse 5, D 40225 Dusseldorf, Germany
    J Biol Chem 287:38590-9. 2012
  3. ncbi Apiaceous vegetable constituents inhibit human cytochrome P-450 1A2 (hCYP1A2) activity and hCYP1A2-mediated mutagenicity of aflatoxin B1
    Sabrina Peterson
    Interdisciplinary Graduate Program in Nutritional Sciences, University of Washington, and Fred Hutchinson Cancer Research Center, Seattle, WA 98195 4695, USA
    Food Chem Toxicol 44:1474-84. 2006
  4. ncbi Effects of Urtica dioica L. seed on lipid peroxidation, antioxidants and liver pathology in aflatoxin-induced tissue injury in rats
    Zabit Yener
    Department of Pathology, Yuzuncu Yil University, Faculty of Veterinary Medicine, 65080 Van, Turkey
    Food Chem Toxicol 47:418-24. 2009
  5. pmc TOXBASE: poisons information on the internet
    D N Bateman
    National Poisons Information Service Edinburgh, Scottish Poisons Information Bureau, Royal Infirmary, Edinburgh, UK
    Emerg Med J 19:31-4. 2002
  6. pmc Genetics of taste and smell: poisons and pleasures
    DANIELLE RENEE REED
    Monell Chemical Senses Center, Philadelphia, Pennsylvania, USA
    Prog Mol Biol Transl Sci 94:213-40. 2010
  7. ncbi Changes in zooxanthellae density, morphology, and mitotic index in hermatypic corals and anemones exposed to cyanide
    J M Cervino
    University of South Carolina, Columbia, SC 29801, USA
    Mar Pollut Bull 46:573-86. 2003
  8. ncbi Natural occurrence of aflatoxin B1 in marketed foods and risk estimates of dietary exposure in Koreans
    Hyun Ee Ok
    Food Safety Research Division, Korea Food Research Institute, San 516, Baekhyun, Bundang, Sungnam 463 746, South Korea
    J Food Prot 70:2824-8. 2007
  9. ncbi A simple steady-state model for carry-over of aflatoxins from feed to cow's milk
    Jan C H van Eijkeren
    National Institute for Public Health and the Environment, PO Box 1, Bilthoven, The Netherlands
    Food Addit Contam 23:833-8. 2006
  10. ncbi Determination of aflatoxin B1 in tiger nut-based soft drinks
    I Arranz
    Food Safety and Quality Unit, Institute for Reference Materials and Measurements, European Commission Joint Research Centre, Retieseweg, B 2440 Geel, Belgium
    Food Addit Contam 23:305-8. 2006

Detail Information

Publications251 found, 100 shown here

  1. ncbi Chromosome instability in human hepatocellular carcinoma depends on p53 status and aflatoxin exposure
    Pascal Pineau
    Unité d Organisation Nucléaire et Oncogénèse, INSERM U579, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France
    Mutat Res 653:6-13. 2008
    ..4% vs. 16.7%, p<0.0001). We suggest that AFB1-associated mutagenesis represents a plausible cause for the higher chromosome instability observed in Chinese HCCs, when compared with European primary liver carcinomas...
  2. pmc Rac1 protein signaling is required for DNA damage response stimulated by topoisomerase II poisons
    Stefanie C Huelsenbeck
    Institute of Toxicology, Heinrich Heine University Dusseldorf, Moorenstrasse 5, D 40225 Dusseldorf, Germany
    J Biol Chem 287:38590-9. 2012
    To investigate the potency of the topoisomerase II (topo II) poisons doxorubicin and etoposide to stimulate the DNA damage response (DDR), S139 phosphorylation of histone H2AX (γH2AX) was analyzed using rat cardiomyoblast cells (H9c2)...
  3. ncbi Apiaceous vegetable constituents inhibit human cytochrome P-450 1A2 (hCYP1A2) activity and hCYP1A2-mediated mutagenicity of aflatoxin B1
    Sabrina Peterson
    Interdisciplinary Graduate Program in Nutritional Sciences, University of Washington, and Fred Hutchinson Cancer Research Center, Seattle, WA 98195 4695, USA
    Food Chem Toxicol 44:1474-84. 2006
    ..These results suggest that in vivo CYP1A2 inhibition by apiaceous vegetables may be due to the phytochemicals present and imply that apiaceous vegetable intake may be chemopreventive by inhibiting CYP1A2-mediated carcinogen activation...
  4. ncbi Effects of Urtica dioica L. seed on lipid peroxidation, antioxidants and liver pathology in aflatoxin-induced tissue injury in rats
    Zabit Yener
    Department of Pathology, Yuzuncu Yil University, Faculty of Veterinary Medicine, 65080 Van, Turkey
    Food Chem Toxicol 47:418-24. 2009
    ..It is concluded that UDS has a hepatoprotective effect in rats with aflatoxicosis, probably acting by promoting the antioxidative defense systems...
  5. pmc TOXBASE: poisons information on the internet
    D N Bateman
    National Poisons Information Service Edinburgh, Scottish Poisons Information Bureau, Royal Infirmary, Edinburgh, UK
    Emerg Med J 19:31-4. 2002
    To assess the uptake, usage and acceptability of TOXBASE, the National Poisons Information Service internet toxicology information service.
  6. pmc Genetics of taste and smell: poisons and pleasures
    DANIELLE RENEE REED
    Monell Chemical Senses Center, Philadelphia, Pennsylvania, USA
    Prog Mol Biol Transl Sci 94:213-40. 2010
    ..To guide food selection, the senses of taste and smell have evolved to alert us to the bitter taste of poisons and the sour taste and off-putting smell of spoiled foods...
  7. ncbi Changes in zooxanthellae density, morphology, and mitotic index in hermatypic corals and anemones exposed to cyanide
    J M Cervino
    University of South Carolina, Columbia, SC 29801, USA
    Mar Pollut Bull 46:573-86. 2003
    ..Even brief exposure to cyanide caused slow-acting and long-term damage to corals and their zooxanthellae...
  8. ncbi Natural occurrence of aflatoxin B1 in marketed foods and risk estimates of dietary exposure in Koreans
    Hyun Ee Ok
    Food Safety Research Division, Korea Food Research Institute, San 516, Baekhyun, Bundang, Sungnam 463 746, South Korea
    J Food Prot 70:2824-8. 2007
    ..78 x 10(-6) for hepatitis B-negative individuals and 1.48 x 10(-4) for hepatitis B-positive individuals. These results suggest that special consideration is required to reduce the intake of AFB1 in hepatitis B-positive individuals...
  9. ncbi A simple steady-state model for carry-over of aflatoxins from feed to cow's milk
    Jan C H van Eijkeren
    National Institute for Public Health and the Environment, PO Box 1, Bilthoven, The Netherlands
    Food Addit Contam 23:833-8. 2006
    ..05 microg AFM1 kg(-1) milk being exceeded...
  10. ncbi Determination of aflatoxin B1 in tiger nut-based soft drinks
    I Arranz
    Food Safety and Quality Unit, Institute for Reference Materials and Measurements, European Commission Joint Research Centre, Retieseweg, B 2440 Geel, Belgium
    Food Addit Contam 23:305-8. 2006
    ..Twenty-two samples from Spanish and Belgian supermarkets were analysed. As a result, only one sample was found to contain aflatoxin B1 at the limit of quantitation of the method...
  11. ncbi Survey of aflatoxins in beer sold in Canada
    M Mably
    Food Laboratories Division, Health Products and Food Branch, Health Canada, 2301 Midland Avenue, Scarborough, Ontario M1P 4R7, Canada
    Food Addit Contam 22:1252-7. 2005
    ....
  12. ncbi Liquid chromatography/photodiode array detection for determination of strychnine in blood: a fatal case report
    Charlotte Duverneuil
    Laboratoire de Pharmacologie Toxicologie, Centre Hospitalier Universitaire Raymond Poincare, 104 Boulevard R Poincaré, 92380 Garches, France
    Forensic Sci Int 141:17-21. 2004
    ..06 and 0.5 mg/l, respectively. The recovery was 94% and the coefficients of variation (CV) ranged from 5.9 to 10.8%. A fatal case of strychnine poisoning is presented, with a lethal blood concentration of 25 mg/l...
  13. ncbi A sensitive confirmatory method for aflatoxins in maize based on liquid chromatography/electrospray ionization tandem mass spectrometry
    Chiara Cavaliere
    Department of Chemistry, La Sapienza University, Piazzale Aldo Moro 5, 00185 Rome, Italy
    Rapid Commun Mass Spectrom 21:550-6. 2007
    ..Of the 48 samples, 15 were found to be contaminated with AFs and, of these, 5 did not comply with European Union legislation (AFB1 </=2 microg/kg)...
  14. ncbi Spermatotoxic effect of aflatoxin B1 in rat: extrusion of outer dense fibres and associated axonemal microtubule doublets of sperm flagellum
    K Faisal
    Department of Animal Science, School of Life Sciences, Bharathidasan University, Tiruchirappalli 620 024, India
    Reproduction 135:303-10. 2008
    ..This sperm abnormality is reported for the first time as produced by a dietary toxin. Dietary aflatoxins, therefore, could also be contributory factors for the deterioration of the reproductive health of men...
  15. ncbi Antigenotoxic effect of Saccharomyces cerevisiae on the damage produced in mice fed with aflatoxin B(1) contaminated corn
    E Madrigal-Santillán
    Laboratorio de Genetica, Escuela Nacional de Ciencias Biologicas, I P N, Carpio y Plan de Ayala Sto Tomas, México D F Cp 11340, Mexico
    Food Chem Toxicol 44:2058-63. 2006
    ..The mixture was filtered to obtain two phases, and AFB(1) content was measured. Sc revealed a potent adsorbent capacity; however, chromatographic determination suggested no structural modification...
  16. ncbi The toxicity and decreased concentration of aflatoxin B in natural lactic acid fermented maize meal
    M P Mokoena
    Department of Biotechnology, Durban Institute of Technology, Durban, South Africa
    J Appl Microbiol 100:773-7. 2006
    ..This study was carried out to investigate the potential activity of lactic acid fermentation in reducing AFB(1) level in fermented maize meal products...
  17. ncbi Aflatoxin B1 contamination in wheat grain samples collected from different geographical regions of India: A multicenter study
    G S Toteja
    Central Coordinating Unit, Indian Council of Medical Research, New Delhi 110029, India
    J Food Prot 69:1463-7. 2006
    ..Human health hazards associated with such AFB1 exposure over time cannot be ruled out...
  18. ncbi Aflatoxin B(1) contamination of parboiled rice samples collected from different states of India: A multi-centre study
    G S Toteja
    Central Coordinating Unit, Indian Council of Medical Research, New Delhi, India
    Food Addit Contam 23:411-4. 2006
    ..4%) and urban (14.5%) data. A median value of 15 microg kg(-1) of aflatoxin B(1) was observed in samples from Assam, Bihar and Tripura. In all other states surveyed the median value was <5 microg?kg(-1)...
  19. ncbi [Inactivation of aflatoxin B1 and aflatoxicol through traditional "nixtamalización" of corn and their regeneration by acidification of corn dough]
    Gloria Laura Anguiano-Ruvalcaba
    Laboratorio de Micotoxinas, Departamento de Biotecnologia y Bioquimica, Unidad Irapuato, Centro de Investigacion y de Estudios Avanzados del IPN, Irapuato, Guanajuato, Mexico
    Salud Publica Mex 47:369-75. 2005
    ..To ratify the effect of traditional "nixtamalización" upon aflatoxin in corn, to identify the residual compound in dough, to evaluate its toxicity, and to verify the effect of acidic treatment on the regeneration of aflatoxin...
  20. ncbi Aflatoxin B1 binding by a mixture of Lactobacillus and Propionibacterium: in vitro versus ex vivo
    S Gratz
    Department of Clinical Nutrition, Mediteknia, University of Kuopio, P O Box 1627, FIN 70211 Kuopio, Finland
    J Food Prot 68:2470-4. 2005
    ..However, probiotic mixture could only retard but not prevent AFB1 absorption in duodenal loops. Further work needs to assess the potential of probiotics in different experimental setups...
  21. ncbi Human nails as a biomarker of arsenic exposure from well water in Inner Mongolia: comparing atomic fluorescence spectrometry and neutron activation analysis
    M T Schmitt
    US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Biomarkers 10:95-104. 2005
    ..0001). Based on the results, INAA was significantly correlated with AFS and proved to be a reliable measure of nail As levels. In this population, toenail samples are a useful internal As exposure biomarker from drinking water sources...
  22. ncbi Bioaccessibility and excretion of arsenic in Niu Huang Jie Du Pian pills
    Iris Koch
    Environmental Sciences Group, PO Box 17000 Station Forces, Royal Military College of Canada, Kingston, Ontario, Canada K7K 7B4
    Toxicol Appl Pharmacol 222:357-64. 2007
    ..Bioaccessible arsenic is comparable to the quantity excreted. Facial hair as a bio-indicator should be further tested...
  23. ncbi Hydrogen sulfide mediates hypoxia-induced relaxation of trout urinary bladder smooth muscle
    Ryan A Dombkowski
    South Bend Center for Medical Education, Indiana University School of Medicine, University of Notre Dame, Notre Dame, IN 46556, USA
    J Exp Biol 209:3234-40. 2006
    ..These experiments suggest that H2S is a phylogenetically ancient gasotransmitter in non-mammalian non-vascular smooth muscle and that it serves as an oxygen sensor/transducer, mediating the effects of hypoxia...
  24. ncbi Herbal medicine causing likely strychnine poisoning
    T Y K Chan
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories
    Hum Exp Toxicol 21:467-8. 2002
    ..In any patient with 'unexplained' muscle spasms or convulsions, strychnine poisoning should be included in the differential diagnosis and they should be asked about the use of herbal medicines...
  25. ncbi Strychnine intoxication in a child
    Orna Starretz-Hacham
    Department of Pediatrics D, Pediatric Intensive Care Unit, Soroka University Hospital and Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Isr Med Assoc J 5:531-2. 2003
  26. ncbi Acute toxicity studies of alpha-ketoglutarate: a promising antidote for cyanide poisoning
    R Bhattacharya
    Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Jhansi Road, Gwalior 474002, India
    J Appl Toxicol 21:495-9. 2001
    ..The results indicate that alpha-KG at 2.0 g kg(-1) (p.o.)-a dose offering maximum antidotal efficacy-is non-toxic and therefore can be considered suitable for cyanide poisoning...
  27. ncbi Promising role of alpha-ketoglutarate in protecting against the lethal effects of cyanide
    R Bhattacharya
    Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Jhansi Road, Gwalior 474002, Madhya Pradesh, India
    Hum Exp Toxicol 21:297-303. 2002
    ..Considering the efficacy and safety of peroral alpha-KG, a promising treatment regimen consisting of alpha-KG + STS or alpha-KG + SN + STS is proposed depending upon the situation...
  28. ncbi [The importance and value of the toxicological and biochemical results in the management of the poisoned patient]
    Barbara Groszek
    Przegl Lek 64:191-3. 2007
    ..It is not always possible to relate symptoms and blood concentrations of drugs and poisons. In many cases, it is necessary to monitor biochemical parameters in the management of poisoned patient.
  29. ncbi Diagnosis and management of the poisoned child
    J Dave Barry
    Medical Toxicology Consulation Service, Department of Emergency Medicine, Brooke Army Medical Center, Fort Sam Houston, TX 78234 6200, USA
    Pediatr Ann 34:937-46. 2005
    ..Prevention efforts have the potential to decrease the incidence of pediatric poisonings. The universal poison control center number provided should be distributed and posted in homes, clinics, and emergency departments...
  30. pmc The lexiconography of toxicology
    Kevin C Osterhoudt
    J Med Toxicol 2:1-3. 2006
  31. ncbi Calcium ions: its role in cyanide neurotoxicity
    D C Mathangi
    Department of Physiology, Dr ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai 600 113, India
    Food Chem Toxicol 42:359-61. 2004
    ..This study showed that DIL pretreatment prevented cyanide induced changes in the dopaminergic and serotonergic system in the corpus striatum...
  32. ncbi A longitudinal assessment of aflatoxin M1 excretion in breast milk of selected Egyptian mothers
    Nektaria Polychronaki
    Department of Public Health and Clinical Nutrition, University of Kuopio, Finland
    Food Chem Toxicol 45:1210-5. 2007
    ..The identification and understanding of factors determining the presence of toxicants in human milk is important and may provide a knowledge driven basis for controlling the transfer of chemicals to infants...
  33. ncbi Urinary biomarkers of aflatoxin exposure in young children from Egypt and Guinea
    Nektaria Polychronaki
    Department of Clinical Nutrition, University of Kuopio, Finland
    Food Chem Toxicol 46:519-26. 2008
    ..These data suggest that measures to reduce aflatoxin exposure in both regions are important, though particularly in Guinea...
  34. ncbi Changes in hepatic cytosolic glutathione S-transferase activity and expression of its class-P during prenatal and postnatal period in rats treated with aflatoxin B1
    Faezeh Fatemi
    Department of Biochemistry Faculty of Medical Science, Tarbiat Modarres University, P O Box 14115 331, Tehran, Iran
    Arch Toxicol 80:572-9. 2006
    ..Furthermore, lack of influence of AFB1 on GST-P expression in developmental stages can role out the involvement of this class of GST in AFB1 biotransformation...
  35. pmc Hepatitis B virus x gene and cyanobacterial toxins promote aflatoxin B1-induced hepatotumorigenesis in mice
    Min Lian
    School of Public Health, Fudan University, 138 Yixueyuan Road, Shanghai 200032, China
    World J Gastroenterol 12:3065-72. 2006
    ..To assess the combinative role of aflatoxin B1(AFB1), cyanobacterial toxins (cyanotoxins), and hepatitis B virus (HBV) x gene in hepatotumorigenicity...
  36. ncbi Skin tumorigenic potential of aflatoxin B1 in mice
    Shipra Rastogi
    Food Toxicology Laboratory, Industrial Toxicology Research Centre, Mahatma Gandhi Marg, P O Box 80, Lucknow 226 001, India
    Food Chem Toxicol 44:670-7. 2006
    ..The overall results indicate a tumor initiating potential of AFB1 in mice and suggest that continued dermal exposure of AFB1, even at low doses, might lead to degenerative changes in hepatocytes...
  37. ncbi Analysis of strychnine and brucine in postmortem specimens by RP-HPLC: a case report of fatal intoxication
    Zhaohong Wang
    School of Pharmaceutical Sciences, Peking University, Beijing 100083, China
    J Anal Toxicol 28:141-4. 2004
    ..Strychnine and brucine were detected in all the samples. The concentration in our case is consistent with that in previous reports...
  38. ncbi Influences of aflatoxin B1 on reactive oxygen species generation and chemotaxis of human polymorphonuclear leukocytes
    Tsuneyuki Ubagai
    Department of Microbiology and Immunology, Teikyo University School of Medicine, Kaga 2 11 1, Itabashi ku, Tokyo 173 8605, Japan
    Toxicol In Vitro 22:1115-20. 2008
    ..These results suggest that a high concentration of AFB1 reduces the chemotactic ability of PMNs via the CXCR1/2 cascade indirectly...
  39. ncbi Aflatoxin treatment brings about generation of multinucleate giant spermatids (symplasts) through opening of cytoplasmic bridges: light and transmission electron microscopic study in Swiss mouse
    Abdul Faridha
    Department of Animal Science, School of Life Sciences, Bharathidasan University, Tiruchirappalli, India
    Reprod Toxicol 24:403-8. 2007
    ....
  40. ncbi Smoking habit and genetic factors associated with lung cancer in a population highly exposed to arsenic
    M Adonis
    Laboratorio de Bioquímica y Toxicología Ambiental, Facultad de Medicina, ICBM, Universidad de Chile, Independencia 1027, P O Box 70087, Santiago 7, Chile
    Toxicol Lett 159:32-7. 2005
    ....
  41. ncbi Urinary arsenic profile affects the risk of urothelial carcinoma even at low arsenic exposure
    Yeong Shiau Pu
    Department of Urology, National Taiwan University College of Medicine, Taipei, Taiwan
    Toxicol Appl Pharmacol 218:99-106. 2007
    ..Subjects who have an unfavorable urinary arsenic profile have an increased UC risk even at low exposure levels...
  42. ncbi Neuropsychological correlates of hair arsenic, manganese, and cadmium levels in school-age children residing near a hazardous waste site
    Robert O Wright
    Harvard School of Public Health, USA
    Neurotoxicology 27:210-6. 2006
    ..No other significant relationships were found. These results suggest the need to study further the neuropsychological correlates of developmental exposure to Mn and As, particularly as a mixture...
  43. ncbi Determination of blood cyanide by HPLC-MS
    A Tracqui
    Institut de Medecine Legale, Strasbourg, France
    J Anal Toxicol 26:144-8. 2002
    ..Limits of detection and quantitation for blood CN are 5 and 15 ng/mL, respectively. The use of 13C15N as internal standard allows the quantitation of CN with elegance and accuracy in comparison with previously reported methods...
  44. ncbi Interindividual variation in the metabolism of arsenic in cultured primary human hepatocytes
    Zuzana Drobna
    Department of Pediatrics, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Toxicol Appl Pharmacol 201:166-77. 2004
    ..Thus, genetic polymorphism of cyt19 along with other cellular factors is likely responsible for interindividual differences in the capacity of primary human hepatocytes to retain and metabolize iAs(III)...
  45. ncbi Research toward the development of a biologically based dose response assessment for inorganic arsenic carcinogenicity: a progress report
    Harvey J Clewell
    CIIT Centers for Health Research, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 222:388-98. 2007
    ....
  46. ncbi Enhancement of platelet aggregation and thrombus formation by arsenic in drinking water: a contributing factor to cardiovascular disease
    Moo Yeol Lee
    College of Pharmacy, Seoul National University, Seoul, 151 742, Korea
    Toxicol Appl Pharmacol 179:83-8. 2002
    ....
  47. ncbi Comparative genomic hybridization study of arsenic-exposed and non-arsenic-exposed urinary transitional cell carcinoma
    Ling I Hsu
    The Genomics Research Center, Academia Sinica, Taipei, Taiwan
    Toxicol Appl Pharmacol 227:229-38. 2008
    ..The findings suggest that long-term arsenic exposure may increase the chromosome abnormality in TCC, and 17p loss plays an important role in arsenic-induced urinary carcinogenesis...
  48. ncbi Drinking water arsenic exposure and blood pressure in healthy women of reproductive age in Inner Mongolia, China
    Richard K Kwok
    RTI International, PO Box 12194, 3040 Cornwallis Rd, Research Triangle Park, NC 27709 2194, USA
    Toxicol Appl Pharmacol 222:337-43. 2007
    ..If our study results are confirmed in other populations, the potential burden of cardiovascular disease attributable to drinking water arsenic is significant...
  49. ncbi Bioassessment of an Appalachian headwater stream influenced by an abandoned arsenic mine
    Theodore W Valenti
    Aquatic Ecotoxicology Lab, Department of Biology, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
    Arch Environ Contam Toxicol 49:488-96. 2005
    ..At the study site, elevated As concentrations likely prevent recruitment of benthic macroinvertebrates and recovery of the perturbed headwater stream...
  50. ncbi Determination of arsenic in homeopathic drugs by bromide volatilization-inductively coupled plasma-atomic emission spectrometry
    Angel Lopez-Molinero
    University of Zaragoza, Faculty of Science, Department of Analytical Chemistry, Spain
    J AOAC Int 85:31-5. 2002
    ..The precision (% relative standard deviation) of the determination was 4.2% at a level of 50 microg/mL As(III) (n = 5). The interference effect of various ions on the arsenic signal was evaluated...
  51. ncbi Insights into the carcinogenic mode of action of arsenic
    A D Kligerman
    Environmental Carcinogenesis Division, National Health and Environmental Effects Research Laboratory, B143 06 US Environmental Protection Agency Research Triangle Park, NC 27711, USA
    Toxicol Appl Pharmacol 222:281-8. 2007
    ..We then propose promising areas of research that might give insight into the MOA of arsenic...
  52. ncbi Arsenic and diabetes and hypertension in human populations: a review
    Chien Jen Chen
    Genomics Research Center, Academia Sinica, 128 Academia Road Section 2, Nankang, Taipei 11529, Taiwan
    Toxicol Appl Pharmacol 222:298-304. 2007
    ..The dose-response relationship and toxicological mechanisms of arsenic-induced diabetes and hypertension need further elucidation...
  53. ncbi A review and rationale for studying the cardiovascular effects of drinking water arsenic in women of reproductive age
    Richard K Kwok
    RTI International, PO Box 12194, 3040 Cornwallis Rd, Research Triangle Park, NC 27709 2194, USA
    Toxicol Appl Pharmacol 222:344-50. 2007
    ..Studying sensitive clinical and sub-clinical indicators of disease in susceptible sub-populations may yield important information about the potentially enormous burden of disease related to low-level drinking water arsenic exposure...
  54. ncbi Residential exposure to drinking water arsenic in Inner Mongolia, China
    Zhixiong Ning
    Ba Men Anti Epidemic Station, Lin He, Inner Mongolia, China
    Toxicol Appl Pharmacol 222:351-6. 2007
    ....
  55. ncbi Arsenic: carcinogen or cancer therapy?
    Kathryn Senior
    Drug Discov Today 7:156-7. 2002
  56. ncbi Molecular processes in cellular arsenic metabolism
    David J Thomas
    Experimental Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, 109 T W Alexander Drive, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 222:365-73. 2007
    ..It may also be useful in development of biologically based dose-response models describing the toxic and carcinogenic actions of arsenicals...
  57. ncbi A rapid screening procedure for drugs and poisons in gastric contents by direct injection-HPLC analysis
    Lucia Politi
    Department of Legal Medicine and Public Health, University of Pavia, Via Forlanini, 12 27100 Pavia, Italy
    Forensic Sci Int 141:115-20. 2004
    ..On the other hand, the system suffers from a relatively limited sensitivity for compounds with a low UV absorption and from interferences due to the presence in the matrix of some highly UV- and FL-responsive compounds (e.g. tryptophan)...
  58. ncbi Group-II metabotropic glutamate receptors negatively modulate NMDA transmission at striatal cholinergic terminals: role of P/Q-type high voltage activated Ca++ channels and endogenous dopamine
    Flora Mela
    Section of Pharmacology, and Neuroscience Center, Department of Experimental and Clinical Medicine, University of Ferrara, Via Fossato di Mortara 17 19, 44100 Ferrara, Italy
    Mol Cell Neurosci 31:284-92. 2006
    ..We conclude that group-II mGlu receptors attenuate NMDA inputs at striatal cholinergic terminals via Ca++ channel modulation and dopamine-sensitive pathways...
  59. ncbi Elevation of intracellular ca(2+) concentration induced by hypoxia in retinal ganglion cells
    Tsugihisa Sasaki
    Department of Ophthalmology, Kanazawa University School of Medicine, Kanazawa, Ishikawa, Japan
    Jpn J Ophthalmol 51:175-80. 2007
    ..To analyze the mechanism of hypoxia-induced changes of the intracellular Ca(2+) concentration ([Ca(2+)](i)) in retinal ganglion cells (RGCs)...
  60. ncbi Notch signalling and voltage-gated Na+ channel activity in human prostate cancer cells: independent modulation of in vitro motility
    N Scorey
    Neuroscience Solutions to Cancer Research Group, Division of Cell and Molecular Biology, Imperial College London, South Kensington Campus, London, UK
    Prostate Cancer Prostatic Dis 9:399-406. 2006
    ..However, the effect of Dll1 was independent of Notch signalling through Hes1 and voltage-gated Na(+) channel expression/activity...
  61. ncbi Restoration by VIP of the carbachol-stimulated Cl- secretion in TTX-treated guinea pig distal colon
    A Kokubo
    Department of Physiology, Kitasato University School of Medicine, Sagamihara, Japan
    Jpn J Physiol 55:317-24. 2005
    ..The exact mechanism of VIP's effect on the TTX-inhibited epithelial Cl(-) secretion, and its possible usefulness in the treatment of TTX-induced pathophysiological conditions, remain to be determined...
  62. pmc In vitro cross-resistance and collateral sensitivity in seven resistant small-cell lung cancer cell lines: preclinical identification of suitable drug partners to taxotere, taxol, topotecan and gemcitabin
    P B Jensen
    Laboratory of Experimental Medical Oncology, The Finsen Center, Rigshospitalet, Copenhagen, Denmark
    Br J Cancer 75:869-77. 1997
    ..These are the topoisomerase I (topo I) poisons topotecan and irinotecan, which are both camptothecin derivatives, the taxane tubulin stabilizers taxol and ..
  63. ncbi Fab antibody fragments: some applications in clinical toxicology
    Robert J Flanagan
    Medical Toxicology Unit, Guy s and St Thomas NHS Foundation Trust, London, UK
    Drug Saf 27:1115-33. 2004
    ..fragments (Fab) from cleaved antibodies to treat poisoning with digoxin and other potent, low formula mass poisons, such as colchicine and tricyclic antidepressants...
  64. ncbi The availability of toxicological analyses for poisoned patients in Ireland
    Nicola Cassidy
    National Poisons Information Centre, Beaumont Hospital, Dublin, Ireland
    Clin Toxicol (Phila) 48:373-9. 2010
    The National Poisons Information Service and the Association of Clinical Biochemists in the United Kingdom published guidelines on laboratory analyses for poisoned patients in 2002. In 2003, U.S...
  65. ncbi Incidence of herb-induced aconitine poisoning in Hong Kong: impact of publicity measures to promote awareness among the herbalists and the public
    Thomas Y K Chan
    Division of Clinical Pharmacology, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, China
    Drug Saf 25:823-8. 2002
    ..An information leaflet was also sent to hospital doctors. Since 1992, the topic was covered periodically in the local newspapers, medical journals and continuing medical education programmes...
  66. ncbi War and hunting poisons of the New World. Part 1. Notes on the early history of curare
    N G Bisset
    Chelsea Department of Pharmacy, Kings College London, University of London, U K
    J Ethnopharmacol 36:1-26. 1992
    ..Study of its physiology started at about that time with the classical experiments of Rudolf von Koelliker and Claude Bernard...
  67. pmc REM sleep behavior disorder in patients with guadeloupean parkinsonism, a tauopathy
    Valerie Cochen De Cock
    Service de Neurologie, Hopital Saint Antoine, Paris, France
    Sleep 30:1026-32. 2007
    ..It is possibly caused by the ingestion of sour sop (corossol), a tropical fruit containing acetogenins, which are mitochondrial poisons.
  68. ncbi An assessment of antimicrobial consumption in food producing animals in Kenya
    E S Mitema
    Faculty of Veterinary Medicine, Department of Public Health, Pharmacology and Toxicology, University of Nairobi, Nairobi, Kenya
    J Vet Pharmacol Ther 24:385-90. 2001
    ..Data on quantities of active substance classes were collected from the official records of the Pharmacy and Poisons Board of the Ministry of Health and analysed in MS Excel 2000 program...
  69. pmc Phase I dose escalation study of vinorelbine and topotecan combination chemotherapy in patients with recurrent lung cancer
    Matthew A Beldner
    Division of Medical Oncology Hematology, Hollings Cancer Center, Medical University of South Carolina, 96 Jonathan Lucas Street, Charleston, SC 29425, USA
    BMC Cancer 7:231. 2007
    ..Preclinical data suggests synergy between topoisomerase I inhibitors and mitotic spindle poisons. Considerable hematologic toxicities have been reported with topotecan dosed for 5 consecutive days in ..
  70. ncbi Role of water in aging of human butyrylcholinesterase inhibited by echothiophate: the crystal structure suggests two alternative mechanisms of aging
    Florian Nachon
    The Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska 68198 6805, USA
    Biochemistry 44:1154-62. 2005
    Organophosphorus poisons (OP) bind covalently to the active-site serine of cholinesterases. The inhibited enzyme can usually be reactivated with powerful nucleophiles such as oximes...
  71. pmc Evidence for paralytic shellfish poisons in the freshwater cyanobacterium Lyngbya wollei (Farlow ex Gomont) comb. nov
    W W Carmichael
    Department of Biological Sciences, Wright State University, Dayton, Ohio 45435, USA
    Appl Environ Microbiol 63:3104-10. 1997
    ..Fifty field samples were placed in unialgal culture and grown under defined culture conditions. Toxicity and signs of poisoning for these laboratory-grown strains of L. wollei were similar to those of the field collection samples...
  72. ncbi The role of transferrin in actinide(IV) uptake: comparison with iron(III)
    Aurélie Jeanson
    CEA, Nuclear Energy Division, Radiochemistry Process Department, SCPS LILA, 30207 Bagnols sur Ceze, France
    Chemistry 16:1378-87. 2010
    ..From a general point of view, these studies show that actinides are chemical poisons as well as radiological hazards...
  73. ncbi Pesticide regulation, utilization, and retailers' selling practices in Trinidad and Tobago, West Indies: current situation and needed changes
    Lexley M Pinto Pereira
    Faculty of Medical Sciences, University of the West Indies, St Augustine, Trinidad, West Indies
    Rev Panam Salud Publica 22:83-90. 2007
    ..To explore pesticide regulation in Trinidad and Tobago, and to ascertain pesticide utilization and retailers' selling practices on Trinidad, which is the larger of twin islands that constitute the republic of Trinidad and Tobago...
  74. ncbi Patient education and consumer medicine information: a study of provision by Queensland rural and remote area Registered Nurses
    Desley Hegney
    Centre of Rural and Remote Area Health, University of Southern Queensland, University of Queensland, Toowoomba, QLD, Australia
    J Clin Nurs 14:855-62. 2005
    ..and enrolled nurses in rural and remote areas of Queensland after the introduction of the Health (Drugs and Poisons) Regulation...
  75. ncbi Toxins as weapons of mass destruction. A comparison and contrast with biological-warfare and chemical-warfare agents
    J M Madsen
    Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, National Capital Consortium Residency in Occupational and Environmental Medicine, Bethesda, Maryland, USA
    Clin Lab Med 21:593-605. 2001
    ..by molecular weight, source, preferred targets in the body, and mechanism of action, they include the most potent poisons on the planet, although considerations of production, weaponization, delivery, environmental stability, and host ..
  76. pmc Effects of licence change on prescribing and poisons enquiries for antipsychotic agents in England and Scotland
    D N Bateman
    Scottish Poisons Information Bureau, Royal Infirmary of Edinburgh, Edinburgh, UK
    Br J Clin Pharmacol 55:596-603. 2003
    ..examine the effect of licence change for thioridazine at the end of 2000 on the prescription of antipsychotic drugs in England and Scotland, and investigate changes in poisons information inquiries and, for Edinburgh, poisons admissions.
  77. ncbi Covalent attachment of ethidium to DNA results in enhanced topoisomerase II-mediated DNA cleavage
    G Marx
    Department of Chemistry, University of Mississippi, University, Mississippi 38677, USA
    Biochemistry 36:15884-91. 1997
    ..drug per 10-80 base pairs) which correspond to nanomolar concentrations, as compared with other topoisomerase II poisons such as etoposide or m-AMSA which require micromolar concentrations to elicit comparable DNA cleavage levels...
  78. ncbi Chinese hamster ovary cells resistant to the topoisomerase II catalytic inhibitor ICRF-159: a Tyr49Phe mutation confers high-level resistance to bisdioxopiperazines
    M Sehested
    Department of Pathology, Rigshospitalet, Copenhagen, Denmark
    Cancer Res 58:1460-8. 1998
    Anticancer drugs targeted to the nuclear enzyme DNA topoisomerase II are classified as poisons that lead to DNA breaks or catalytic inhibitors that appear to completely block enzyme activity...
  79. ncbi Phase II and pharmacokinetic/pharmacodynamic trial of sequential topoisomerase I and II inhibition with topotecan and etoposide in advanced non-small-cell lung cancer
    A Dowlati
    Division of Hematology Oncology, Case Western Reserve University and University Hospitals of Cleveland, Ohio 44106, USA
    Cancer Chemother Pharmacol 47:141-8. 2001
    ..Topoisomerase I inhibitors increase topoisomerase II levels and increase cell kill induced by topoisomerase II poisons. We evaluated this hypothesis in a cohort of patients with advanced non-small-cell lung cancer (NSCLC).
  80. ncbi Immunohistochemical investigation of pulmonary surfactant-associated protein A in fatal poisoning
    B L Zhu
    Department of Legal Medicine, Osaka City University Medical School, Asahi machi 1 4 3, Abeno, 545 8585, Osaka, Japan
    Forensic Sci Int 117:205-12. 2001
    ..of pulmonary surfactant-associated protein A (SP-A) in fatal poisoning in relation to the effects of drugs and poisons on respiratory function, 42 forensic autopsy cases were examined by scoring the staining intensity...
  81. pmc A specialized citric acid cycle requiring succinyl-coenzyme A (CoA):acetate CoA-transferase (AarC) confers acetic acid resistance on the acidophile Acetobacter aceti
    Elwood A Mullins
    Department of Biochemistry, Purdue University, West Lafayette, Indiana 47907, USA
    J Bacteriol 190:4933-40. 2008
    ..oxidation of ethanol to acetic acid and are generally resistant to high levels of these two membrane-permeable poisons. The citric acid cycle (CAC) is linked to acetic acid resistance in Acetobacter aceti by several observations, ..
  82. ncbi Inhibitors of topoisomerase II as pH-dependent modulators of etoposide-mediated cytotoxicity
    S W Langer
    Laboratory of Experimental Medical Oncology, The Finsen Center, Rigshospitalet, Copenhagen, Denmark
    Clin Cancer Res 5:2899-907. 1999
    Chloroquine intercalates into DNA and protects cells against topoisomerase II (topo II) poisons such as etoposide by hindering the DNA cleavage reaction of this target enzyme...
  83. ncbi Dose-escalation and pharmacodynamic study of topotecan in combination with cyclophosphamide in patients with refractory cancer
    J R Murren
    Department of Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    J Clin Oncol 15:148-57. 1997
    Based on preclinical data that demonstrated synergy between alkylating agents and topoisomerase (topo) I poisons, we determined the maximum-tolerated dose (MTD) of topotecan, using a 5 day bolus schedule, that could be given in ..
  84. ncbi Analysis of paralytic shellfish toxins in Aphanizomenon DC-1 from Lake Dianchi, China
    Yongmei Liu
    State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, Hubei, 430072, People s Republic of China
    Environ Toxicol 21:289-95. 2006
    ..bioassay with extracts from the lyophilized field material showed obvious intoxication from paralytic shellfish poisons (PSPs), and all mice died within 30 min...
  85. ncbi [Study on the relationship between vascular endothelial growth factor and syndrome type of traditional Chinese medicine in patients with gastric carcinoma]
    Wen Chen
    The Second Affiliated Hospital of Fujian Medical University, Quanzhou Fujian
    Zhongguo Zhong Xi Yi Jie He Za Zhi 27:127-30. 2007
    ....
  86. ncbi Delphinidin modulates the DNA-damaging properties of topoisomerase II poisons
    Melanie Esselen
    Section of Food Toxicology, Institute of Applied Biosciences, Universitat Karlsruhe TH, Adenauerring 20A, 76131 Karlsruhe, Germany
    Chem Res Toxicol 22:554-64. 2009
    ..In addition, DEL diminished the DNA-damaging properties of topoisomerase II poisons in HT29 cells without affecting the level of sites sensitive to formamidopyrimidine-DNA-glycosylase...
  87. ncbi The effect of antimitotic agents on the intraneuronal distribution of lysosomes
    V J Roberts
    Salk Institute, La Jolla, CA 92037
    Brain Res 521:62-72. 1990
    ..the present report we have examined the time course and specificity of this effect using a variety of microtubule poisons. Dipeptidylaminopeptidase II (Dpp II), a lysosomal marker enzyme, histochemistry was used to visualize lysosomes ..
  88. pmc Contribution of aldehyde dehydrogenase to mitochondrial bioactivation of nitroglycerin: evidence for the activation of purified soluble guanylate cyclase through direct formation of nitric oxide
    Alexander Kollau
    Department of Pharmacology and Toxicology, Karl Franzens Universitat Graz, Universitatsplatz 2, A 8010 Graz, Austria
    Biochem J 385:769-77. 2005
    ..1 mM), increased the EC50 of GTN to 7.47+/-0.93 microM. Lack of effect of the mitochondrial poisons, rotenone and myxothiazol, suggested that nitrite reduction by components of the respiratory chain is not ..
  89. ncbi Differential poisoning of topoisomerases by menogaril and nogalamycin dictated by the minor groove-binding nogalose sugar
    S P Sim
    Department of Pharmacology, UMDNJ Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    Biochemistry 36:13285-91. 1997
    ..By contrast, nogalamycin poisons topoisomerase I but not topoisomerase II...
  90. ncbi Poisoning due to eating fungi in Victoria
    E Hender
    Victorian Poisons Information Centre, Royal Children s Hospital
    Aust Fam Physician 29:1000-4. 2000
    ..To determine the range of fungi eaten in Victoria and the incidence and severity of associated illness...
  91. ncbi The changes in hazard classification and product notification procedures of the new European CLP and Cosmetics Regulations
    Ronald De Groot
    National Institute for Public Health and the Environment, National Poisons Information Centre, Bilthoven, The Netherlands
    Clin Toxicol (Phila) 48:28-33. 2010
    ..Both old and new classifications will exist simultaneously until 2010 for substances and until 2015 for mixtures...
  92. ncbi Resistance to kynurenic acid of the NMDA receptor-dependent toxicity of 3-nitropropionic acid and cyanide in cerebellar granule neurons
    Amos A Fatokun
    Institute of Biomedical and Life Sciences, University of Glasgow, West Medical Building, Glasgow G12 8QQ, UK
    Brain Res 1215:200-7. 2008
    ..This phenomenon is mimicked by the acute administration of mitochondrial poisons such as 3-nitropropionic acid (3-NPA) and potassium cyanide (KCN), with the production of reactive molecular ..
  93. ncbi Are selective serotonin re-uptake inhibitors associated with an increased risk of self-harm by antidepressant overdose?
    D N Bateman
    Scottish Poisons Information Bureau NPIS Edinburgh, Royal Infirmary of Edinburgh, 51 Little France Crescent, EH10 4SA Edinburgh, Scotland
    Eur J Clin Pharmacol 60:221-4. 2004
    To investigate likelihood of self-harm by overdose with antidepressant drugs of different types by examining hospital admission data and poisons inquiries and relating them to prescribing.
  94. ncbi Does gastric lavage really push poisons beyond the pylorus? A systematic review of the evidence
    Michael Eddleston
    Department of Clinical Medicine, University of Colombo, Colombo, Sri Lanka
    Ann Emerg Med 42:359-64. 2003
    ..In conclusion, it seems that no published data support the statement that gastric lavage forces poison into the small bowel...
  95. ncbi Forensic toxicology
    Olaf H Drummer
    Victorian Institute of Forensic Medicine, Department of Forensic Medicine, Monash University, Australia
    EXS 100:579-603. 2010
    ..the opiates, but can be any other illicit substance or almost any over-the-counter or prescribed drug, as well as poisons available to the community...
  96. ncbi Antidiabetic medications in overdose: a comparison of the inquiries made to a regional poisons unit regarding original sulfonylureas, biguanides and insulin
    M A von Mach
    Medical Department, Division of Clinical Toxicology, University Hospital, Langenbeckstrasse 1, 55131 Mainz, Germany
    Int J Clin Pharmacol Ther 44:51-6. 2006
    ..The present investigation analyzes inquiries made to a regional poisons unit involving overdoses with sulfonylureas, biguanides and insulin.
  97. ncbi Guideline on the use of ipecac syrup in the out-of-hospital management of ingested poisons
    Anthony S Manoguerra
    American Association of Poison Control Centers, Washington, District of Columbia 20016, USA
    Clin Toxicol (Phila) 43:1-10. 2005
    ....
  98. pmc Voreloxin is an anticancer quinolone derivative that intercalates DNA and poisons topoisomerase II
    Rachael E Hawtin
    Sunesis Pharmaceuticals, Inc, South San Francisco, California, United States of America
    PLoS ONE 5:e10186. 2010
    ..This study defined voreloxin's anticancer mechanism of action as a critical component of rational clinical development informed by translational research...
  99. ncbi The National Poisons Information Centre in Sri Lanka: the first ten years
    Ravindra Fernando
    Faculty of Medicine, National Poisons Information Centre, National Hospital of Sri Lanka, Colombo
    J Toxicol Clin Toxicol 40:551-5. 2002
    ..The National Poisons Information Centre in Sri Lanka, thefirst such centre to be established in South Asia, completed 10 years service ..
  100. ncbi Sources of information for acute poisoning in accident and emergency departments in Dublin, Ireland
    T W Holohan
    Eastern Health Board, Department of Public Health, Eastern Health Board, Dublin, Ireland
    J Toxicol Clin Toxicol 38:29-36. 2000
    ..Apart from the National Poisons Information Centre, other information sources can be used...
  101. ncbi Suicidal death after injection of a castor bean extract (Ricinus communis L.)
    Vera Coopman
    Department of Analytical Toxicology, Chemiphar N V, Lieven Bauwensstraat 4, B 8200 Brugge, Belgium
    Forensic Sci Int 189:e13-20. 2009
    ..Ricin is considered as one of the most toxic natural poisons. Ricinine is a piperidine alkaloidal toxin present in castor bean and is described as a biomarker for the ..

Research Grants62

  1. Continuation of FERN Activities at the Connecticut Agricultural Experiment Statio
    LAURIE J PETERSON-WRIGHT; Fiscal Year: 2013
    ..In this proposal we look to continue our advances with this methodology by looking at new toxins and poisons, by expanding to new matrices such as alcohol and seafood, and to explore the potential use of Solid Phase ..
  2. Soft Metal, Disulfide, and Cysteine Stresses in Escherichia coli
    James A Imlay; Fiscal Year: 2013
    ..In recent published work we demonstrated that copper poisons E. coli primarily by inactivating Fe/S-dependent dehydratases...
  3. FUNCTION AND BIOLOGY OF EUKARYOTIC DNA TOPOISOMERASES
    Neil Osheroff; Fiscal Year: 2013
    ..Anticancer drugs that target type II enzymes are referred to as topoisomerase II poisons because they convert these indispensable enzymes to potent physiological toxins that generate DNA damage in ..
  4. Aerosol Delivery of a Recombinant Butyrylcholinesterase "BioShield" to Protect Ag
    YVONNE J ROSENBERG; Fiscal Year: 2012
    ..delivery device to that it deposits in the lung and forms a "bioshield" and detoxifies inhaled indecticides poisons in the lung and prevernts them from reaching the blood and the neuromuscular junctions where they can quickly ..
  5. Optimizing Tissue Iron Quantification at 3 Tesla
    John C Wood; Fiscal Year: 2013
    ..Iron accumulates silently for years but ultimately poisons the liver, endocrine glands and heart. Our laboratory has pioneered the use of 1.5 Tesla (1...
  6. Food and Drug Administration Research FERN Chemistry Cooperative Agreement: MN De
    MICHELLE DAWN CAMPBELL; Fiscal Year: 2013
    ..Use of Gas Chromatograph - Mass Spectrometry (GC-MS) analysis for the screening and identification of poisons, toxic substances, and unknown compounds in foods; Use of Liquid Chromatograph - Mass Spectrometry (LC-MS) ..
  7. Test to Predict Effectiveness of Docetaxel Treatment
    Carol Swartz; Fiscal Year: 2013
    ..Gene expression profiling will be used to assess mechanisms of toxicity known to be driven by mitotic spindle poisons like Docetaxel...
  8. Mechanism and Function of Chromatin Positional Dynamics in Interphase
    Alexandra Zidovska; Fiscal Year: 2013
    ..specifically inhibiting major nuclear ATPases (polymerase II, DNA polymerase and topoisomerase) using molecular poisons or RNA interference and analyzing the spatio-temporal changes in the pattern of measured chromatin dynamics (aim ..
  9. Screening of inhibitors for human 5-prime-tyrosyl DNA phosphodiesterase (hTDP2)
    Sanjay Adhikari; Fiscal Year: 2013
    ..Despite their clinical efficacy, drugs that target TopII (TopII poisons) may lead to negative side-effects, including secondary malignancies...
  10. EPIGENETIC CONTROL OF NHEJ DNA REPAIR
    Robert A Hromas; Fiscal Year: 2013
    ..We also found that Metnase also mediates resistance to Topo II poisons, which cause DSBs, in cancer cell lines...
  11. Discovering small molecules that overcome differentiation arrest in acute myeloid
    David B Sykes; Fiscal Year: 2012
    ..Traditional chemotherapy, which typically poisons rapidly dividing leukemia cells, is ultimately ineffective in 75% of cases...
  12. Role of Prolyl Hydroxylase Oxygen-Sensor in Cardioprotection
    Gary Wright; Fiscal Year: 2011
    ..the mitochondrion during a metabolic insult and promotes mitochondrial recovery upon washout of metabolic poisons or reoxygenation...
  13. pHLIP Nanotechnology Platform for Cancer Imaging and Therapy
    Yana K Reshetnyak; Fiscal Year: 2012
    ..Such improvements are especially important for cancer treatment, since the majority of anti-cancer drugs are poisons that damage normal cells.
  14. Impairment of axonal transport by Amyloid precursor protein and amyloid Beta-prot
    Lawrence S Goldstein; Fiscal Year: 2011
    ..it is crucial to understand the consequences of APP overexpression in neurons, and in particular how excess APP poisons axonal transport...
  15. Topoisomerases: Target for Antitrypanosomal Therapy
    Theresa Shapiro; Fiscal Year: 2009
    ..to the clinic by exploring the structure- activity relationship and selective toxicity of known topoisomerase IB poisons against trypanosomes in vitro, and by screening a defined chemical library to identify new topoisomerase poisons ..
  16. Oxidative Dysfunction of LRP at the Blood-brain Barrier in Alzheimer's Disease
    William A Banks; Fiscal Year: 2012
    ..This suggests that ABP poisons its own transporter, LRP...
  17. ANTI-TOPOISOMERASE DRUG ACTION IN YEAST
    John L Nitiss; Fiscal Year: 2013
    ..Clinically active Top2 targeting agents lead to enzyme mediated DNA damage, and are referred to as Top2 poisons. Detailed information about the action of Top2 poisons has the potential for leading to safer and more active ..
  18. New Hampshire Food Safety and Security Monitoring Project - Chemistry
    CHRISTINE LOUISE BEAN; Fiscal Year: 2013
    ..With this FDA support, we have enhanced our contaminated product- tampering response to include semi-volatile poisons by gas chromatography/mass spectrometry (GC-MS), non-volatile poisons by liquid chromatography/mass spectrometry/..
  19. MOLECULAR BASIS OF HEART FAILURE
    ANDREW ROBERT MARKS; Fiscal Year: 2013
    ..proposes to test the hypothesis of a "vicious cycle" between RyR2 and mitochondria due to Ca2+ leak via RyR2 that poisons mitochondria resutling in increased ROS prodcution which further oxidizes RyR2 and exacerbates the leak...
  20. Central Respiratory Effects of Organophosphate Poisoning
    Romolo J Gaspari; Fiscal Year: 2010
    ..Prior research has shown that patients poisoned with organophosphate poisons simply stop breathing. The PI has chosen Dr. David Paydarfar as a mentor for this project...
  21. MECHANISM OF GLUTATHIONE CONJUGATE DEPENDENT TOXICITY
    Arthur Cooper; Fiscal Year: 2007
    ..BCKAD) are targets of TFEC in rat kidney cells in vivo, and that halogenated cysteine S-conjugates are metabolic poisons of isolated kidney and liver mitochondria...
  22. In Situ Sensing System for the Selective and Sensitive Detection of Biological To
    Hyeok Choi; Fiscal Year: 2013
    ..Microcystins are among the most powerful natural poisons known...
  23. Genetically Engineered Viruses for Prostate Cancer Therapy
    Robert L Martuza; Fiscal Year: 2013
    ..of proangiogenic factors induced by hypoxia and that this effect can be further enhanced by microtubule-spindle poisons. PUBLIC HEALTH RELEVANCE: Current treatment modalities for localized prostate cancer include surgery and ..
  24. Optimization of dipeptide-linked benzimidazole topoisomerase 1 poisons
    Craig Beeson; Fiscal Year: 2009
    ..However, limitations in CPT pharmaceutical properties have driven the search for new CPT-like poisons that target the Top1 protein-DNA cleavage complex...
  25. 14 3 3 Implications in Topoisomerase II Pharmacology
    David Kroll; Fiscal Year: 2003
    ..by protein-protein interactions and modulation of these proteins may influence tumor cell response to topo II poisons. Since we originally identified the transcription factors CREB, ATF-2, and c-Jun as topo lI-interactive proteins (..
  26. Anti-Cancer Drug Design Targeting Human Topoisomerase I
    Lance Stewart; Fiscal Year: 2002
    Human topoisomerase I (topo I) is the sole intracellular target of camptothecin (CPT) and other "topo I poisons," some of which are among the most promising anticancer drugs ever identified. Emerald BioStructures, Inc...
  27. ENDOCRINOLOGY OF MOSQUITO REPRODUCTION
    ARDEN LEA; Fiscal Year: 1991
    ..e., microencapsulation and protein engineering of peptides as stomach poisons and insertion of genes for regulatory peptides in species-specific microorganisms.
  28. LTP AND SPATIAL LEARNING
    TIMOTHY TEYLER; Fiscal Year: 2002
    ..The two patterns of stimulation are differentially sensitive to different enzymatic poisons: Serine/threonine kinase poison H-7 inhibits PKC, PKA, PKG, and CamKII, and prevents NMDA-dependent LTP induction ..
  29. SYNTHESIS OF TAXININE AND TAXOL
    CHARLES SWINDELL; Fiscal Year: 1992
    ..Taxol possesses intriguing activity as a mitotic spindle poison. Unlike classical spindle poisons (e.g...
  30. MECHANISMS OF TOPOISOMERASE POISONS
    Hiroshi Hiasa; Fiscal Year: 2002
    ..q., ciprofloxacin). These drugs convert topoisomerases to poisons that inhibit DNA replication and lead to double-strand break (DSB) generation...
  31. MECHANISM OF BOTULINUM TOXIN ACTION
    LANCE SIMPSON; Fiscal Year: 2006
    ..This toxin, which is generally regarded as the most poisonous of all poisons, is known to exist in seven serotypes designated A, B, C, D, E, F and G...
  32. A NOVEL F BOX PROTEIN REGULATING MITOSIS
    Peter Jackson; Fiscal Year: 2004
    ..coupling spindle control to a metaphase block and apoptosis, SBP5 may participate in the pathway that microtubule poisons like Taxol and vinca alkaloids use to trigger cell death...
  33. STRUCTURE/FUNCTION OF TWO DNA BINDING PROTEINS
    WILHELMUS HOL; Fiscal Year: 2004
    ..Also the precise mode of action of a number of inhibitors of human topoisomerase I, called "topo poisons", will be investigated. These include compthothecin derivatives recently introduced for the treatment of cancer...
  34. Sensor for Paralytic Shellfish Poisons
    ROBERT GAWLEY; Fiscal Year: 2006
    ..Paralytic Shellfish Poisons (PSPs) enter the human food chain most commonly through filter-feeding shellfish transvectors...
  35. From Nanoparticles to Novel Protective Garments
    Shyamala Rajagopalan; Fiscal Year: 2004
    ..and saboteurs use a variety of toxic industrial chemicals to create improvised explosives, chemical agents and poisons. When dealing with situations involving hazardous materials, released either by accident or on purpose, ..
  36. CALMODULIN INHIBITORS EFFECT ON ADRIAMYCIN RESISTANCE
    Ram Ganapathi; Fiscal Year: 1999
    The basic theme of this application is to establish mechanisms by which the topoisomerase II poisons adriamycin or etoposide and the inhibitors of calcium-calmodulin regulated processes, trifuluoperazine and 1-[N-O- bis(1,5-..
  37. Novel anti-melanoma agents and their mechanism of action
    Harish Joshi; Fiscal Year: 2009
    ..Based upon structural similarities to microtubule poisons (colchicine, podophylotoxin, MTC), we identified a tubulin binding natural compound, noscapine (Ye et al., 1998)...
  38. CHEMISTRY AND BIOCHEMISTRY OF AQUATIC TOXINS
    Yuzuru Shimizu; Fiscal Year: 1999
    ..and biosynthesis of 1) excitatory amino acids such as domoic acid and kainic acid; 2) paralytic shellfish poisons (PSP) such as saxitoxin and gonyautoxins; 3) polyether toxins such as brevetoxins and okadaic acid derivatives; 4)..
  39. REGULATION OF TOPOISOMERASE II-DRUG-DNA TERNARY COMPLEX
    Ram Ganapathi; Fiscal Year: 2006
    ..Expression and activity of these kinases in cells exhibiting differential sensitivity to topo II poisons will be determined...
  40. Topoisomerase I-directed Anticancer Drugs
    Leroy Liu; Fiscal Year: 2004
    ..In addition to CPTs, a growing list of compounds (TOP1 poisons) (e.g...
  41. RECEPTORS AS TARGETS FOR INSECTICIDES
    AMIRA ELDEFRAWI; Fiscal Year: 1991
    Until effective insect-selective poisons are discovered, a balance must be established between the need to minimize the adverse environmental impact of insecticides and the need to maximize the survival and health of humans...
  42. TOPOISOMERASE DRUG ACTIONS AT NUCLEAR MATRIX DNA DOMAIN
    Daniel Fernandes; Fiscal Year: 2003
    ..The central hypothesis to be tested is that topoisomerase I and II poisons irreversibly damage DNA by preferentially inducing double-strand DNA breaks in replication forks on the nuclear ..
  43. Topoisomerase II-directed drugs and cell death
    John Robertson; Fiscal Year: 2006
    ..Of particular interest is how topoisomerase II (topo2) poisons, which cause double-stranded DNA breaks and are among the most effective and widely prescribed antineoplastic ..
  44. TOPOISOMERASE I STRUCTURE AND REGULATION
    Eric Rubin; Fiscal Year: 1999
    ..of these mutations on camptothecin binding and on the inhibitory activity of noncamptothecin topoisomerase T poisons such as Hoechst dye 33342 and actinomycin D...
  45. ANTICANCER COMPOUNDS DESIGNED TO POISON TOPOISOMERASE I
    Lance Stewart; Fiscal Year: 2000
    Human topoisomerase I (topoI) is the sole intracellular target of camptothecin (CPT) and other "topo I poisons," some of which are among the most promising anticancer drugs ever identified. Emerald BioStructures, Inc...
  46. MECHANISMS OF SUPPRESSING CAMPTOTHECIN TOXICITY
    Mary Ann Bjornsti; Fiscal Year: 2003
    ..processes or the potential induction of secondary malignancies following the therapeutic application of Top1 poisons. This application aims to fill the void in our understanding of the cytotoxic action of Top1 poisons by ..
  47. New mitosis specific anticancer agents
    Julian Simon; Fiscal Year: 2005
    ..cancer chemotherapy, tubulin has been validated as an anticancer drug target through the success of the spindle poisons (i.e. paclitaxel and vinblastine). In a broad sense, tubulin is a component of the pathway of mitosis...
  48. SUMOylation and Cell Sensitivity to Top1 Poisons
    Mary Ann Bjornsti; Fiscal Year: 2009
    ..The goal of this proposal is to define the role of Ubc9-catalyzed sumoylation in protecting cells from Top1p poisons in the yeast Saccharomyces cerevisiae...
  49. NITRIC OXIDE, PLP ACYLATION & THE PATHOPHYSIOLOGY OF MS
    OSCAR BIZZOZERO; Fiscal Year: 2003
    ..myelinating rats will be incubated with [3H]palmitate and H2/18/O, in the presence of a variety of metabolic poisons and enzyme inhibitors to ascertain whether PLP acylation (a) needs ATP, (b) requires the formation acyl-CoA, (c) ..
  50. SYNTHESIS OF INDOLOCARBAZOLES AS TOPOISOMERASE I POISONS
    David Zembower; Fiscal Year: 2000
    ..application): The goal of this Phase II project is the synthesis and evaluation of indolocarbazole analogues as poisons of human topoisomerase I (Topo I), an enzyme which represents an attractive target for development of antitumor ..
  51. THE APICOPLAST: A NEW TARGET FOR ANTI-MALARIAL DRUGS
    James Bigelow; Fiscal Year: 2001
    ..We have preliminary data supporting our hypothesis that chloroplast poisons kill the parasite...
  52. CORRELATIONS OF NEW AND OLD CELL KINETIC PARAMETERS
    Claudio Nicolini; Fiscal Year: 1980
    ..of flow and static cytometry determine effects of other DNA antimetabolites (such as hydroxyurea) and antimitotic poisons (such as vincristine) on: a) the cell kinetics and the progression of cells through the cycle, b) chromatin ..
  53. Expand the capability and capacity of the State of Colorado Chemistry Laboratorie
    LAURIE J PETERSON-WRIGHT; Fiscal Year: 2013
    ..over the next five years to continue its efforts to expand the current database of matrices screened for toxins, poisons and adulterants...
  54. CHROMOSOMAL ABNORMALITIES IN RAT MAMMARY CARCINOGENESIS
    C Marcelo Aldaz; Fiscal Year: 1993
    ..To reproduce the malignant progression events chromosomal aneuploidy will be induced in RME cells using mitotic poisons such as Colcemid and diethlystilbestrol (DES). The phenotypic effects of both experimental interventions, i.e...
  55. DNA LESIONS AS ENDOGENOUS TOPOISOMERASE POISONS
    Neil Osheroff; Fiscal Year: 2009
    ..Anticancer drugs targeted to the type II enzyme are referred to as topoisomerase II poisons because they convert this essential enzyme to a potent physiological toxin that fragments the genome...
  56. TOPOISOMERASE-1 INHIBITORS: NOVEL THERAPY OF UPPER GI CA
    Howard Hochster; Fiscal Year: 1993
    The goal of this project is to elucidate the mechanism of action of camptothecin analogs as topoisomerase poisons in upper GI cancer patients...
  57. NOVEL DOUBLE STRAND BREAK PRODUCING COMPOUNDS
    Julian Simon; Fiscal Year: 2001
    ..A subset of the new compounds are structurally novel and do not behave like topo I or II poisons. They may thus represent entirely new classes of DSB inducing agents...
  58. Brief Child Safety Interventions in Emergency Department
    Andrea Gielen; Fiscal Year: 2004
    ..The intervention will address the use of car safety seats, working smoke alarms, and safely stored poisons because these are effective countermeasures known to help prevent the leading causes of childhood injury, namely ..
  59. Bioflavonoids as DNA Topoisomerase II Poisons
    OMARI BANDELE; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Bioflavonoids are potent topoisomerase II poisons and are believed to be chemopreventative in adults...
  60. MONITORING MUTAGENS WITH MAMMALIAN CHROMOSOMES
    T Hsu; Fiscal Year: 1980
    For the year 1980-81, research will concentrate on the in vivo effects of mutagens and mitotic poisons. Since this project is designed to work out assay systems instead of testing unknown compounds, we plan to use unknown mutagens for ..
  61. Cell responses to, and proteins exploited by, toxins
    John Lord; Fiscal Year: 2009
    by applicant): Ricin and Shiga toxin are among the most potent poisons known. They are able to kill mammalian cells by catalytically inactivating ribosomes...
  62. ANTINEOPLASTIC POLYAMINE ANALOGUES
    Patrick Woster; Fiscal Year: 2004
    ..discovered, specifically the abilities to produced a G2/M block, alter tubulin polymerization and act as spindle poisons; 4) The study of these unique analogues has led to the discovery that the natural polyamines may have the ..