insecticides

Summary

Summary: Pesticides designed to control insects that are harmful to man. The insects may be directly harmful, as those acting as disease vectors, or indirectly harmful, as destroyers of crops, food products, or textile fabrics.

Top Publications

  1. ncbi Pyrethroid resistance in African anopheline mosquitoes: what are the implications for malaria control?
    Hilary Ranson
    Vector Group, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, UK, L3 5QA
    Trends Parasitol 27:91-8. 2011
  2. pmc Loss of household protection from use of insecticide-treated nets against pyrethroid-resistant mosquitoes, benin
    Alex Asidi
    London School of Hygiene and Tropical Medicine, London, UK
    Emerg Infect Dis 18:1101-6. 2012
  3. pmc Species shifts in the Anopheles gambiae complex: do LLINs successfully control Anopheles arabiensis?
    Jovin Kitau
    Kilimanjaro Christian Medical College, Tumaini University, Moshi, Tanzania
    PLoS ONE 7:e31481. 2012
  4. pmc Identification and validation of a gene causing cross-resistance between insecticide classes in Anopheles gambiae from Ghana
    Sara N Mitchell
    Vector Group, Liverpool School of Tropical Medicine, Liverpool L35QA, United Kingdom
    Proc Natl Acad Sci U S A 109:6147-52. 2012
  5. pmc Anopheles gambiae: historical population decline associated with regional distribution of insecticide-treated bed nets in western Nyanza Province, Kenya
    M Nabie Bayoh
    Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI, 48824, USA
    Malar J 9:62. 2010
  6. pmc RFID tracking of sublethal effects of two neonicotinoid insecticides on the foraging behavior of Apis mellifera
    Christof W Schneider
    Institut für Bienenkunde, Department of Biological Science, Goethe University, Frankfurt am Main, Germany
    PLoS ONE 7:e30023. 2012
  7. pmc Expression of the cytochrome P450s, CYP6P3 and CYP6M2 are significantly elevated in multiple pyrethroid resistant populations of Anopheles gambiae s.s. from Southern Benin and Nigeria
    Rousseau F Djouaka
    International Institute of Tropical Agriculture, Cotonou, 08BP0932, Benin
    BMC Genomics 9:538. 2008
  8. ncbi Neonicotinoid pesticide reduces bumble bee colony growth and queen production
    Penelope R Whitehorn
    School of Natural Sciences, University of Stirling, Stirling FK9 4LA, UK
    Science 336:351-2. 2012
  9. pmc Transcriptomics of the bed bug (Cimex lectularius)
    Xiaodong Bai
    Department of Entomology, Ohio Agricultural and Research Development Center, The Ohio State University, Wooster, Ohio, United States of America
    PLoS ONE 6:e16336. 2011
  10. pmc Preventing childhood malaria in Africa by protecting adults from mosquitoes with insecticide-treated nets
    Gerry F Killeen
    Ifakara Health Research and Development Centre, Ifakara, Morogoro, United Republic of Tanzania
    PLoS Med 4:e229. 2007

Detail Information

Publications313 found, 100 shown here

  1. ncbi Pyrethroid resistance in African anopheline mosquitoes: what are the implications for malaria control?
    Hilary Ranson
    Vector Group, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, UK, L3 5QA
    Trends Parasitol 27:91-8. 2011
    The use of pyrethroid insecticides in malaria vector control has increased dramatically in the past decade through the scale up of insecticide treated net distribution programmes and indoor residual spraying campaigns...
  2. pmc Loss of household protection from use of insecticide-treated nets against pyrethroid-resistant mosquitoes, benin
    Alex Asidi
    London School of Hygiene and Tropical Medicine, London, UK
    Emerg Infect Dis 18:1101-6. 2012
    ..ITNs provide little or no protection once the mosquitoes become resistant and the netting acquires holes. Resistance seriously threatens malaria control strategies based on ITN...
  3. pmc Species shifts in the Anopheles gambiae complex: do LLINs successfully control Anopheles arabiensis?
    Jovin Kitau
    Kilimanjaro Christian Medical College, Tumaini University, Moshi, Tanzania
    PLoS ONE 7:e31481. 2012
    ..Shifts in malaria vector species ratio have coincided with the scale-up suggesting that some species are being controlled by ITNs/LLINs better than others...
  4. pmc Identification and validation of a gene causing cross-resistance between insecticide classes in Anopheles gambiae from Ghana
    Sara N Mitchell
    Vector Group, Liverpool School of Tropical Medicine, Liverpool L35QA, United Kingdom
    Proc Natl Acad Sci U S A 109:6147-52. 2012
    ..Sustaining these reductions will rely upon insecticides to control the mosquito malaria vectors...
  5. pmc Anopheles gambiae: historical population decline associated with regional distribution of insecticide-treated bed nets in western Nyanza Province, Kenya
    M Nabie Bayoh
    Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI, 48824, USA
    Malar J 9:62. 2010
    ..l.) species complex, namely A. gambiae sensu stricto (s.s.) and Anopheles arabiensis. Historically, the former species was proportionately dominant in indoor resting collections of females...
  6. pmc RFID tracking of sublethal effects of two neonicotinoid insecticides on the foraging behavior of Apis mellifera
    Christof W Schneider
    Institut für Bienenkunde, Department of Biological Science, Goethe University, Frankfurt am Main, Germany
    PLoS ONE 7:e30023. 2012
    The development of insecticides requires valid risk assessment procedures to avoid causing harm to beneficial insects and especially to pollinators such as the honeybee Apis mellifera...
  7. pmc Expression of the cytochrome P450s, CYP6P3 and CYP6M2 are significantly elevated in multiple pyrethroid resistant populations of Anopheles gambiae s.s. from Southern Benin and Nigeria
    Rousseau F Djouaka
    International Institute of Tropical Agriculture, Cotonou, 08BP0932, Benin
    BMC Genomics 9:538. 2008
    ..The mosquitoes were sampled from a variety of breeding sites in a preliminary attempt to investigate the role of contamination of mosquito breeding sites in selecting for resistance in adult mosquitoes...
  8. ncbi Neonicotinoid pesticide reduces bumble bee colony growth and queen production
    Penelope R Whitehorn
    School of Natural Sciences, University of Stirling, Stirling FK9 4LA, UK
    Science 336:351-2. 2012
    ..Neonicotinoid insecticides have been implicated in these declines because they occur at trace levels in the nectar and pollen of crop ..
  9. pmc Transcriptomics of the bed bug (Cimex lectularius)
    Xiaodong Bai
    Department of Entomology, Ohio Agricultural and Research Development Center, The Ohio State University, Wooster, Ohio, United States of America
    PLoS ONE 6:e16336. 2011
    ..Resistance of C. lectularius to insecticides/pesticides is one factor thought to be involved in its sudden resurgence...
  10. pmc Preventing childhood malaria in Africa by protecting adults from mosquitoes with insecticide-treated nets
    Gerry F Killeen
    Ifakara Health Research and Development Centre, Ifakara, Morogoro, United Republic of Tanzania
    PLoS Med 4:e229. 2007
    ..We therefore estimated coverage thresholds for entire populations at which individual- and community-level protection are equivalent, representing rational targets for ITN coverage beyond vulnerable groups...
  11. ncbi Overview of the status and global strategy for neonicotinoids
    Peter Jeschke
    Research Insecticides Chemistry Insecticides, Building 6240, Bayer CropScience AG, Alfred Nobel Strasse 50, D 40789 Monheim am Rhein, Germany
    J Agric Food Chem 59:2897-908. 2011
    In recent years, neonicotinoid insecticides have been the fastest growing class of insecticides in modern crop protection, with widespread use against a broad spectrum of sucking and certain chewing pests...
  12. pmc Field-caught permethrin-resistant Anopheles gambiae overexpress CYP6P3, a P450 that metabolises pyrethroids
    Pie Müller
    Liverpool School of Tropical Medicine, Liverpool, United Kingdom
    PLoS Genet 4:e1000286. 2008
    ..Resistance to pyrethroid insecticides in the malaria vector Anopheles gambiae is receiving increasing attention because it threatens the ..
  13. pmc Insecticide resistance in Anopheles gambiae: data from the first year of a multi-country study highlight the extent of the problem
    Hilary Ranson
    Vector Group, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L35QA, UK
    Malar J 8:299. 2009
    ..The current extent and distribution of this resistance in many parts of the continent is unknown and yet such information is essential for the planning of effective malaria control interventions...
  14. ncbi Mosquito behavior and vector control
    Helen Pates
    London School of Hygiene and Tropical Medicine, London WC1E 7HT, United Kingdom
    Annu Rev Entomol 50:53-70. 2005
    ..Prospects for genetic control by sterile males or genes rendering mosquitoes harmless to humans will depend on competitive mating behavior. These methods are hampered by the immigration of monogamous, already-mated females...
  15. ncbi A single p450 allele associated with insecticide resistance in Drosophila
    P J Daborn
    Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK
    Science 297:2253-6. 2002
    ..This allele is characterized by the insertion of an Accord transposable element into the 5' end of the Cyp6g1 gene...
  16. ncbi Impact of environment on mosquito response to pyrethroid insecticides: facts, evidences and prospects
    Theresia Estomih Nkya
    National Institute of Medical Research of Tanzania, Amani Medical Research Centre, Muheza, Tanga, Tanzania
    Insect Biochem Mol Biol 43:407-16. 2013
    ..Most vector control programmes aiming at controlling life-threatening mosquitoes rely on the use of chemical insecticides, mainly belonging to the pyrethroid class...
  17. ncbi Indoor residual spraying for preventing malaria
    Bianca Pluess
    Public Health and Epidemiology, Swiss Tropical and Public Health Institute, Basel, Switzerland, 4002
    Cochrane Database Syst Rev 4:CD006657. 2010
    ..We also contacted researchers in the field, organizations, and manufacturers of insecticides (June 2007)...
  18. pmc The Anopheles gambiae detoxification chip: a highly specific microarray to study metabolic-based insecticide resistance in malaria vectors
    Jean Philippe David
    Vector Research Group, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L35QA, United Kingdom
    Proc Natl Acad Sci U S A 102:4080-4. 2005
    ..The applications of this detox chip and its potential contribution to malaria vector insecticide resistance management programs are discussed...
  19. pmc Impact of promoting longer-lasting insecticide treatment of bed nets upon malaria transmission in a rural Tanzanian setting with pre-existing high coverage of untreated nets
    Tanya L Russell
    Biomedical and Environmental Thematic Group, Ifakara Health Institute, P O Box 53, Ifakara, Tanzania
    Malar J 9:187. 2010
    ..Since 2006, a national-scale programme has promoted the use of longer-lasting insecticide treatment kits (consisting of an insecticide plus binder) co-packaged with all bed nets manufactured in the country...
  20. ncbi Cytochrome P450 6M2 from the malaria vector Anopheles gambiae metabolizes pyrethroids: Sequential metabolism of deltamethrin revealed
    Bradley J Stevenson
    Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK
    Insect Biochem Mol Biol 41:492-502. 2011
    Resistance to pyrethroid insecticides in the malaria vector Anopheles gambiae is a major threat to malaria control programmes. Cytochome P450-mediated detoxification is an important resistance mechanism...
  21. pmc Role of cytochrome P450s in insecticide resistance: impact on the control of mosquito-borne diseases and use of insecticides on Earth
    Jean Philippe David
    Laboratoire d Ecologie Alpine, UMR 5553, CNRS Universite de Grenoble, BP 53, 38041 Grenoble Cedex 09, France
    Philos Trans R Soc Lond B Biol Sci 368:20120429. 2013
    ..Chemical insecticides remain the first line of defence but the control of diseases, especially malaria and dengue fever, is being ..
  22. pmc Combining indoor residual spraying and insecticide-treated nets for malaria control in Africa: a review of possible outcomes and an outline of suggestions for the future
    Fredros O Okumu
    Ifakara Health Institute, Biomedical and Environmental Sciences Thematic group, P, O Box 53 Ifakara, Tanzania
    Malar J 10:208. 2011
    ..This article concludes by emphasizing the need for basic and operational research, including mathematical modelling to evaluate IRS/ITN combinations in comparison to IRS alone or ITNs alone...
  23. pmc Mode of action of Bacillus thuringiensis Cry and Cyt toxins and their potential for insect control
    Alejandra Bravo
    Departamento de Microbiologia Molecular, Instituto de Biotecnologia, Universidad Nacional Autonoma de Mexico, Apdo, Postal 510 3, Cuernavaca, Morelos 62250, Mexico
    Toxicon 49:423-35. 2007
    ..Also, we discuss their use in the control of agricultural insect pests and insect vectors of human diseases...
  24. pmc Dramatic decrease in malaria transmission after large-scale indoor residual spraying with bendiocarb in Benin, an area of high resistance of Anopheles gambiae to pyrethroids
    Martin Akogbeto
    Centre de Recherche Entomologique de Cotonou, Benin
    Am J Trop Med Hyg 85:586-93. 2011
    ..Bendiocarb was found to be a good alternative insecticide for IRS in Benin, in areas where An. gambiae has developed high resistance to pyrethroids...
  25. pmc Interactions between Nosema microspores and a neonicotinoid weaken honeybees (Apis mellifera)
    Cedric Alaux
    INRA, UMR 406 Abeilles et Environnement, Laboratoire Biologie et Protection de l abeille, Site Agroparc, 84914 Avignon, France
    Environ Microbiol 12:774-82. 2010
    ..This provides the first evidences that interaction between an infectious organism and a chemical can also threaten pollinators, interactions that are widely used to eliminate insect pests in integrative pest management...
  26. ncbi The role of agricultural use of insecticides in resistance to pyrethroids in Anopheles gambiae s.l. in Burkina Faso
    Abdoulaye Diabate
    Laboratoire d Entomologie et de Parasitologie, Centre Muraz, Bobo Dioulasso, Burkina Faso
    Am J Trop Med Hyg 67:617-22. 2002
    Agricultural use of insecticides is involved in the selection of resistance to these compounds in field populations of mosquitoes in Burkina Faso. Anopheles gambiae s.l...
  27. ncbi Pyrethroid tolerance is associated with elevated expression of antioxidants and agricultural practice in Anopheles arabiensis sampled from an area of cotton fields in Northern Cameroon
    Pie Müller
    Vector Group, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK
    Mol Ecol 17:1145-55. 2008
    Spraying of agricultural crops with insecticides can select for resistance in nontarget insects and this may compromise the use of insecticides for the control of vector-borne diseases...
  28. pmc Efficacy of PermaNet® 2.0 and PermaNet® 3.0 against insecticide-resistant Anopheles gambiae in experimental huts in Côte d'Ivoire
    Benjamin G Koudou
    Département Environnement et Santé, Centre Suisse de Recherches Scientifiques, 01 BP 1303 Abidjan 01, Cote d Ivoire
    Malar J 10:172. 2011
    ..PermaNet® 3.0 is impregnated with deltamethrin at 85 mg/m2 on the sides of the net and with deltamethrin and piperonyl butoxide on the roof. PermaNet® 2.0 is impregnated with deltamethrin at 55 mg/m2 across the entire net...
  29. pmc The importance of considering community-level effects when selecting insecticidal malaria vector products
    Gerry F Killeen
    Ifakara Health Institute, Biomedical and Environmental Thematic Group, PO Box 53, Ifakara, Morogoro, United Republic of Tanzania
    Parasit Vectors 4:160. 2011
    ..However, at high coverage, community-level reductions of mosquito density and survival prevent more transmission exposure than the personal protection acquired by using a net or living in a sprayed house...
  30. ncbi Susceptibility status of malaria vectors to insecticides commonly used for malaria control in Tanzania
    Bilali Kabula
    National Institute for Medical Research, Amani Research Centre, Muheza, Tanzania
    Trop Med Int Health 17:742-50. 2012
    ..The aim of the study was to monitor the insecticide susceptibility status of malaria vectors in 12 sentinel districts of Tanzania...
  31. pmc High level of resistance in the mosquito Anopheles gambiae to pyrethroid insecticides and reduced susceptibility to bendiocarb in north-western Tanzania
    Natacha Protopopoff
    Department of Disease Control, London School of Hygiene and Tropical Medicine, Keppel Street, London, UK
    Malar J 12:149. 2013
    ..l to different insecticides and the prevalence of the kdr resistance allele involved in pyrethroid resistance were investigated in north-..
  32. pmc How much does malaria vector control quality matter: the epidemiological impact of holed nets and inadequate indoor residual spraying
    Andrea M Rehman
    MRC Tropical Epidemiology Group, London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS ONE 6:e19205. 2011
    ..Data from three control programs were used to investigate the impact of: 1) the physical deterioration of ITNs, and 2) inadequate IRS spray coverage, on their respective protective effectiveness...
  33. pmc Larval source management for malaria control in Africa: myths and reality
    Ulrike Fillinger
    Department of Disease Control, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Malar J 10:353. 2011
    ....
  34. ncbi Comparative genomics: Insecticide resistance in mosquito vectors
    Mylene Weill
    Institut des Sciences de l Evolution, UMR 5554, CC 065, Universite Montpellier II, 34095 Montpellier, France
    Nature 423:136-7. 2003
  35. ncbi Ingested double-stranded RNAs can act as species-specific insecticides
    Steven Whyard
    Department of Biological Sciences, University of Manitoba, Winnipeg, Manitoba, Canada
    Insect Biochem Mol Biol 39:824-32. 2009
    A serious shortcoming of many insecticides is that they can kill non-target species...
  36. pmc Pyrosequencing the transcriptome of the greenhouse whitefly, Trialeurodes vaporariorum reveals multiple transcripts encoding insecticide targets and detoxifying enzymes
    Nikos Karatolos
    Rothamsted Research, Harpenden, Hertfordshire, UK
    BMC Genomics 12:56. 2011
    ..is an economically important crop pest in temperate regions that has developed resistance to most classes of insecticides. However, the molecular mechanisms underlying resistance have not been characterised and, to date, progress has ..
  37. pmc Insecticide resistance and the future of malaria control in Zambia
    Emmanuel Chanda
    Ministry of Health, National Malaria Control Centre, Lusaka, Zambia
    PLoS ONE 6:e24336. 2011
    ..This manuscript reports on the monitoring and evaluation of these activities and the potential impact of emerging insecticide resistance on disease transmission...
  38. pmc Population dynamics of Anopheles gambiae s.l. in Bobo-Dioulasso city: bionomics, infection rate and susceptibility to insecticides
    Roch K Dabire
    Institut de Recherche en Sciences de la Santé Centre Muraz, 01 BP 390, Bobo Dioulasso 01, Burkina Faso
    Parasit Vectors 5:127. 2012
    ..in more detail the present study aims to provide an update on the malaria vector composition in Bobo-Dioulasso, and also the Plasmodium infection rates and susceptibility to insecticides of the local An. gambiae s.l. population.
  39. pmc Bed bugs evolved unique adaptive strategy to resist pyrethroid insecticides
    Fang Zhu
    Department of Entomology, College of Agriculture, University of Kentucky, Lexington, KY 40546, USA
    Sci Rep 3:1456. 2013
    ..Understanding the complexity of adaptive strategies employed by bed bugs will help in designing the most effective and sustainable bed bug control methods...
  40. ncbi Neuroactive insecticides: targets, selectivity, resistance, and secondary effects
    John E Casida
    Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy, and Management, University of California, Berkeley, California 94720, USA
    Annu Rev Entomol 58:99-117. 2013
    Neuroactive insecticides are the principal means of protecting crops, people, livestock, and pets from pest insect attack and disease transmission...
  41. ncbi Field-evolved resistance to Bt toxin Cry1Ac in the pink bollworm, Pectinophora gossypiella (Saunders) (Lepidoptera: Gelechiidae), from India
    Sanyasi Dhurua
    Division of Entomology, Indian Agricultural Research Institute, New Delhi, India
    Pest Manag Sci 67:898-903. 2011
    ..During the 2007-2008 and 2008-2009 seasons, pink bollworm populations in India were surveyed to evaluate their responses to Cry1Ac and seed powder containing Cry1Ac and Cry2Ab2...
  42. pmc Comparing the effectiveness of malaria vector-control interventions through a mathematical model
    Nakul Chitnis
    Department of Public Health and Epidemiology, Swiss Tropical and Public Health Institute, Basel, Switzerland
    Am J Trop Med Hyg 83:230-40. 2010
    ..Although our model includes some assumptions and approximations that remain to be addressed, these findings should be useful for prioritizing and designing future field research...
  43. ncbi A meta-analysis of experiments testing the effects of a neonicotinoid insecticide (imidacloprid) on honey bees
    James E Cresswell
    School of Biosciences, University of Exeter, Hatherly Laboratories, Prince of Wales Road, Exeter, EX4 4PS, UK
    Ecotoxicology 20:149-57. 2011
    Honey bees provide important pollination services to crops and wild plants. The agricultural use of systemic insecticides, such as neonicotinoids, may harm bees through their presence in pollen and nectar, which bees consume...
  44. pmc A modified experimental hut design for studying responses of disease-transmitting mosquitoes to indoor interventions: the Ifakara experimental huts
    Fredros O Okumu
    Biomedical and Environmental Sciences Thematic group, Ifakara Health Institute, Ifakara, Republic of Tanzania
    PLoS ONE 7:e30967. 2012
    ..wall panels and ceilings, which allow safe insecticide disposal and reuse of the huts to test different insecticides in successive periods, 4) the kit format of the huts allowing portability and 5) an improved suite of ..
  45. ncbi Assessment of insecticide-treated bednet use among children and pregnant women across 15 countries using standardized national surveys
    Thomas P Eisele
    Department of International Health and Development, Tulane School of Public Health and Tropical Medicine, New Orleans, Louisiana 70112, USA
    Am J Trop Med Hyg 80:209-14. 2009
    ..The gaps in ITN use and possession will likely persist in the absence of achieving a ratio of no more than two people per ITN...
  46. ncbi Combination of malaria vector control interventions in pyrethroid resistance area in Benin: a cluster randomised controlled trial
    Vincent Corbel
    Institut de Recherche pour lDéveloppement, Maladies Infectieuses et Vecteurs, Ecologie, Genetique, Evolution et Contrôle IRD 224 CNRS 5290 UM1 UM2, Cotonou, Benin, and Montpellier, France
    Lancet Infect Dis 12:617-26. 2012
    ..Africa are being challenged by the development of resistance of parasites to antimalarial drugs and vectors to insecticides. We investigated whether the combination of long-lasting insecticidal mosquito nets (LLINs) with indoor ..
  47. pmc Dynamics of insecticide resistance in malaria vectors in Benin: first evidence of the presence of L1014S kdr mutation in Anopheles gambiae from West Africa
    Innocent Djegbe
    Centre de Recherche Entomologique de Cotonou, 06 BP 2604, Cotonou, Benin
    Malar J 10:261. 2011
    ..This study reported the spatial and seasonal variations of insecticide resistance in malaria vectors in Benin, West Africa...
  48. pmc First evidence of high knockdown resistance frequency in Anopheles arabiensis (Diptera: Culicidae) from Ethiopia
    Delenasaw Yewhalaw
    Department of Biology, Jimma University, Jimma, Ethiopia
    Am J Trop Med Hyg 83:122-5. 2010
    ..05% deltamethrin from bioassay results was 1.0%, 18.1%, and 82.2%, respectively. We report here the highest kdr allele frequency ever observed in An. arabiensis and its implications in malaria vector control in Ethiopia are discussed...
  49. pmc Combining indoor residual spraying and insecticide-treated net interventions
    Immo Kleinschmidt
    London School of Hygiene and Tropical Medicine, London, United Kingdom
    Am J Trop Med Hyg 81:519-24. 2009
    ..76-0.81) in Bioko and 0.34 (95% CI = 0.21-0.56) in Zambezia. Although the effects of confounding cannot be excluded, these results provide encouragement that the additional resources for combining IRS and LLIN are justified...
  50. pmc Exploiting the potential of vector control for disease prevention
    H Townson
    Liverpool School of Tropical Medicine, Liverpool, England
    Bull World Health Organ 83:942-7. 2005
    ..Following the discovery of synthetic residual insecticides in the 1940s, large-scale programmes succeeded in bringing many of the important vector-borne diseases under ..
  51. ncbi Safety of pyrethroid-treated mosquito nets
    M Zaim
    World Health Organization Pesticides Evaluation Scheme, Strategy Development and Monitoring of Parasitic Diseases and Vector Control, Communicable Diseases Control Prevention and Eradication World Health Organization, Geneva, Switzerland
    Med Vet Entomol 14:1-5. 2000
    ..Because many domestic users of pyrethroid 'home treatment kits' for ITNs may not be fully literate, it is essential that 'instructions for use' should be portrayed via pictograms with supporting text in appropriate local language(s)...
  52. pmc Amplification of a cytochrome P450 gene is associated with resistance to neonicotinoid insecticides in the aphid Myzus persicae
    Alin M Puinean
    Centre for Sustainable Pest and Disease Management, Rothamsted Research, Harpenden, United Kingdom
    PLoS Genet 6:e1000999. 2010
    ..To date, the neonicotinoids, an economically important class of insecticides that target nicotinic acetylcholine receptors (nAChRs), have remained an effective control measure; however, ..
  53. ncbi Suppression of cotton bollworm in multiple crops in China in areas with Bt toxin-containing cotton
    Kong Ming Wu
    State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing, 100193, People s Republic of China
    Science 321:1676-8. 2008
    ..Our data suggest that Bt cotton not only controls H. armigera on transgenic cotton designed to resist this pest but also may reduce its presence on other host crops and may decrease the need for insecticide sprays in general...
  54. ncbi The Innovative Vector Control Consortium: improved control of mosquito-borne diseases
    Janet Hemingway
    Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, UK, L3 5QA
    Trends Parasitol 22:308-12. 2006
    Few new insecticides have been produced for control of disease vectors for public health in developing countries over the past three decades, owing to market constraints, and the available insecticides are often poorly deployed...
  55. ncbi Field-evolved insect resistance to Bt crops: definition, theory, and data
    Bruce E Tabashnik
    Department of Entomology, University of Arizona, Tucson, AZ 85721, USA
    J Econ Entomol 102:2011-25. 2009
    ....
  56. ncbi Impact of permethrin-treated bed nets on entomologic indices in an area of intense year-round malaria transmission
    John E Gimnig
    Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Am J Trop Med Hyg 68:16-22. 2003
    ..These results indicate that ITNs are optimally effective if used every night and if permethrin is reapplied at least biannually...
  57. pmc Effects of transplacental exposure to environmental pollutants on birth outcomes in a multiethnic population
    Frederica P Perera
    Columbia Center for Children s Environmental Health, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    Environ Health Perspect 111:201-5. 2003
    ..This study provides evidence that environmental pollutants at levels currently encountered in New York City adversely affect fetal development...
  58. pmc Aging partially restores the efficacy of malaria vector control in insecticide-resistant populations of Anopheles gambiae s.l. from Burkina Faso
    Christopher M Jones
    Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK
    Malar J 11:24. 2012
    ..In this study, LLINs and IRS were tested against young (three to five days) and old (17-19 days) pyrethroid resistant Anopheles gambiae s.l. from Burkina Faso...
  59. ncbi Applied aspects of neonicotinoid uses in crop protection
    Alfred Elbert
    Bayer CropScience, Development, Agronomic Development, Alfred Nobel Strasse 50, D 40789 Monheim, Germany
    Pest Manag Sci 64:1099-105. 2008
    Neonicotinoid insecticides comprise seven commercially marketed active ingredients: imidacloprid, acetamiprid, nitenpyram, thiamethoxam, thiacloprid, clothianidin and dinotefuran...
  60. ncbi Does kdr genotype predict insecticide-resistance phenotype in mosquitoes?
    Martin J Donnelly
    Vector Group, Liverpool School of Tropical Medicine, Liverpool L35QA, UK
    Trends Parasitol 25:213-9. 2009
    ..However, we emphasize that kdr genotype might explain only a portion of heritable variation in resistance and that diagnostic assays to test the importance of other resistance mechanisms in field populations are required...
  61. pmc Exposure to sublethal doses of fipronil and thiacloprid highly increases mortality of honeybees previously infected by Nosema ceranae
    Cyril Vidau
    Clermont Universite, Laboratoire Microorganismes Génome et Environnement, BP 10448, Clermont Ferrand, France
    PLoS ONE 6:e21550. 2011
    ..Our study was designed to explore the effect of Nosema ceranae infection on honeybee sensitivity to sublethal doses of the insecticides fipronil and thiacloprid.
  62. ncbi Neonicotinoids-from zero to hero in insecticide chemistry
    Peter Jeschke
    Bayer CropScience AG, Research Insecticides Chemistry Insecticides, Building 6240, Alfred Nobel Str 50, D 40789 Monheim am Rhein, Germany
    Pest Manag Sci 64:1084-98. 2008
    In recent years, neonicotinoids have been the fastest-growing class of insecticides in modern crop protection, with widespread use against a broad spectrum of sucking and certain chewing pests...
  63. pmc Long-term field performance of a polyester-based long-lasting insecticidal mosquito net in rural Uganda
    Albert Kilian
    Malaria Consortium, Development House, 56 64 Leonard Street EC2A 4JX, London, UK
    Malar J 7:49. 2008
    ....
  64. pmc Evidence of increasing Leu-Phe knockdown resistance mutation in Anopheles gambiae from Niger following a nationwide long-lasting insecticide-treated nets implementation
    Cyrille Czeher
    Parasitology Unit, centre de recherche médicale et sanitaire, Institut Pasteur International Network, Niamey, Niger
    Malar J 7:189. 2008
    ..A large number of studies in Africa have reported the existence of anopheline populations resistant to various insecticides, partly due to knockdown resistance (kdr) mutations, but few operational wide-scale control programmes were ..
  65. ncbi An experimental hut evaluation of PermaNet(®) 3.0, a deltamethrin-piperonyl butoxide combination net, against pyrethroid-resistant Anopheles gambiae and Culex quinquefasciatus mosquitoes in southern Benin
    Raphael N'Guessan
    London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E7HT, UK
    Trans R Soc Trop Med Hyg 104:758-65. 2010
    ..Against C. quinquefasciatus, no treatment killed >24% entering the huts. The synergism from unwashed PermaNet 3.0 was lower than expected, probably due to an unidentified resistance mechanism unaffected by PBO...
  66. ncbi Historical review of malarial control in southern African with emphasis on the use of indoor residual house-spraying
    Musawenkosi L H Mabaso
    Malaria Research Programme, Medical Research Council, Durban, South Africa
    Trop Med Int Health 9:846-56. 2004
    ..Immediately after the inception of IRS with insecticides, dramatic reductions in malaria and its vectors were recorded...
  67. pmc Multiple insecticide resistance: an impediment to insecticide-based malaria vector control program
    Delenasaw Yewhalaw
    Department of Biology, Jimma University, Jimma, Ethiopia
    PLoS ONE 6:e16066. 2011
    ..However, the development of resistance by mosquitoes to insecticides recommended for IRS and/or ITNs/LLINs would affect insecticide-based malaria vector control...
  68. ncbi Impact of sustained use of insecticide-treated bednets on malaria vector species distribution and culicine mosquitoes
    K A Lindblade
    Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 4770 Buford Hwy MS F 22, Atlanta GA 30333, USA
    J Med Entomol 43:428-32. 2006
    ..Reductions in culicines by ITNs may have implications for community perceptions of ITN effectiveness and for control of other diseases such as lymphatic filariasis...
  69. pmc Detoxification enzymes associated with insecticide resistance in laboratory strains of Anopheles arabiensis of different geographic origin
    Luisa Nardini
    Vector Control Reference Unit, Centre for Opportunistic, Tropical and Hospital Infections, National Institute for Communicable Diseases of the National Health Laboratory Services, Johannesburg, South Africa
    Parasit Vectors 5:113. 2012
    The use of insecticides to control malaria vectors is essential to reduce the prevalence of malaria and as a result, the development of insecticide resistance in vector populations is of major concern...
  70. pmc A periodically-forced mathematical model for the seasonal dynamics of malaria in mosquitoes
    Nakul Chitnis
    Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland
    Bull Math Biol 74:1098-124. 2012
    ....
  71. pmc Bacillus thuringiensis: A story of a successful bioinsecticide
    Alejandra Bravo
    Instituto de Biotecnologia, Universidad Nacional Autonoma de Mexico, Apdo Postal 510 3, Cuernavaca 62250, Morelos, Mexico
    Insect Biochem Mol Biol 41:423-31. 2011
    ..Also, recent data on insect responses to Cry toxin attack is discussed. Finally, we review the different Bt based products, including transgenic crops, that are currently used in agriculture...
  72. pmc Restricted application of insecticides: a promising tsetse control technique, but what do the farmers think of it?
    Fanny Bouyer
    Centre International de Recherche Développement sur l Elevage en zone Sub humide CIRDES, Bobo Dioulasso, Burkina Faso
    PLoS Negl Trop Dis 5:e1276. 2011
    Restricted application of insecticides to cattle is a cheap and safe farmer-based method to control tsetse. In Western Africa, it is applied using a footbath, mainly to control nagana and the tick Amblyomma variegatum...
  73. ncbi Do insecticide-treated bednets have an effect on malaria vectors?
    Willem Takken
    Laboratory of Entomology, Wageningen University, Wageningen, The Netherlands
    Trop Med Int Health 7:1022-30. 2002
    ..of ITNs on mosquito biology and ecology, other than the development of insecticide resistance against the insecticides used...
  74. pmc The combination of indoor residual spraying and insecticide-treated nets provides added protection against malaria compared with insecticide-treated nets alone
    Mary J Hamel
    Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, Georgia 30301, USA
    Am J Trop Med Hyg 85:1080-6. 2011
    ..50-0.72). The combination of IRS and ITN might be a feasible strategy to further reduce malaria transmission in areas of persistent perennial malaria transmission...
  75. pmc Potential benefits, limitations and target product-profiles of odor-baited mosquito traps for malaria control in Africa
    Fredros O Okumu
    Biomedical and Environmental Sciences Thematic group, Ifakara Health Institute, Ifakara, United Republic of Tanzania
    PLoS ONE 5:e11573. 2010
    ..We investigated the potential benefits of such traps for preventing malaria transmission in Africa and the essential characteristics that they should possess so as to be effective...
  76. pmc Bendiocarb, a potential alternative against pyrethroid resistant Anopheles gambiae in Benin, West Africa
    Martin C Akogbeto
    Centre de Recherche Entomologique de Cotonou CREC, Cotonou, Bénin 06 BP 2604
    Malar J 9:204. 2010
    Anopheles gambiae, the main malaria vector in Benin has developed high level of resistance to pyrethroid insecticides, which is a serious concern to the future use of long-lasting insecticidal nets (LLIN) and indoor residual spraying (IRS)..
  77. ncbi Gene expression in insecticide resistant and susceptible Anopheles gambiae strains constitutively or after insecticide exposure
    J Vontas
    Institute of Molecular Biology and Biotechnology IMBB FORTH, Vassilika Vouton, Heraklion, Crete, Greece
    Insect Mol Biol 14:509-21. 2005
    ..Several genes belonging to enzyme families already implicated in insecticide or xenobiotic detoxification were induced, including the carboxylesterase COEAE2F gene and members of the UDP-glucuronosyl transferase and nitrilase families...
  78. pmc Anopheles gambiae distribution and insecticide resistance in the cities of Douala and Yaoundé (Cameroon): influence of urban agriculture and pollution
    Christophe Antonio-Nkondjio
    Laboratoire de Recherche sur le Paludisme, Organisation de Coordination pour la lutte contre les Endémies en Afrique Centrale OCEAC, P O Box 288, Yaounde, Cameroon
    Malar J 10:154. 2011
    ..A study was undertaken to assess the importance of urban pollution and agriculture practice on the distribution and susceptibility to insecticide of malaria vectors in the two main cities in Cameroon...
  79. pmc Spatial and temporal variation in the kdr allele L1014S in Anopheles gambiae s.s. and phenotypic variability in susceptibility to insecticides in Western Kenya
    Derrick K Mathias
    Centre for Global Health Research, Kenya Medical Research Institute, PO Box 1578, Kisumu, Kenya
    Malar J 10:10. 2011
    Malaria vector control in Africa depends upon effective insecticides in bed nets and indoor residual sprays. This study investigated the extent of insecticide resistance in Anopheles gambiae s.l., Anopheles gambiae s.s...
  80. ncbi Cross-induction of detoxification genes by environmental xenobiotics and insecticides in the mosquito Aedes aegypti: impact on larval tolerance to chemical insecticides
    Rodolphe Poupardin
    Laboratoire d Ecologie Alpine, UMR CNRS Université Joseph Fourier 5553, Equipe Perturbations Environnementales et Xénobiotiques, Domaine Universitaire de Saint Martin d Hères 2233, rue de la piscine Bât D Biologie, BP 53, 38041 Grenoble Cedex 9, France
    Insect Biochem Mol Biol 38:540-51. 2008
    ..the polycyclic aromatic hydrocarbon fluoranthene and the heavy metal copper on their subsequent tolerance to insecticides, detoxification enzyme activities and expression of detoxification genes was investigated...
  81. pmc Insecticide resistance in malaria vector mosquitoes at four localities in Ghana, West Africa
    Richard H Hunt
    Malaria Entomology Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
    Parasit Vectors 4:107. 2011
    ..control programmes that rely on insecticide-based interventions such as indoor house spraying with residual insecticides or insecticide treated bed nets, need to base their decision-making process on sound baseline data...
  82. pmc Defining challenges and proposing solutions for control of the virus vector Aedes aegypti
    Amy C Morrison
    Department of Entomology, University of California, Davis, Davis, California, United States of America
    PLoS Med 5:e68. 2008
  83. pmc Insecticide control of vector-borne diseases: when is insecticide resistance a problem?
    Ana Rivero
    Génétique et Evolution des Maladies Infectieuses UMR CNRS 2724, Centre de Recherche IRD, Montpellier, France
    PLoS Pathog 6:e1001000. 2010
    ..of repeated insecticide use, all of these vector species have demonstrated the capacity to evolve resistance to insecticides. Insecticide resistance is generally considered to undermine control of vector-transmitted diseases because it ..
  84. pmc Impact of prenatal chlorpyrifos exposure on neurodevelopment in the first 3 years of life among inner-city children
    Virginia A Rauh
    Columbia Center for Children s Environmental Health, Mailman School of Public Health, Columbia University, 60 Haven Ave, B 109, New York, NY 10032, USA
    Pediatrics 118:e1845-59. 2006
    ..The purpose of this study was to investigate the impact of prenatal exposure to chlorpyrifos on 3-year neurodevelopment and behavior in a sample of inner-city minority children...
  85. ncbi Towards a comprehensive simulation model of malaria epidemiology and control
    T Smith
    Swiss Tropical Institute, Socinstrasse 57, PO Box, CH 4002 Basel, Switzerland
    Parasitology 135:1507-16. 2008
    ..The project thus provides a general platform for comparing, fitting, and evaluating different model structures, and for quantitative prediction of effects of different interventions and integrated control programmes...
  86. ncbi From malaria control to eradication: The WHO perspective
    Kamini Mendis
    Global Malaria Programme, World Health Organization, Geneva, Switzerland
    Trop Med Int Health 14:802-9. 2009
    ..are under the constant threat of the parasite and vector mosquito developing resistance to medicines and insecticides, which are the cornerstones of current antimalarial interventions...
  87. pmc Early warning of cotton bollworm resistance associated with intensive planting of Bt cotton in China
    Haonan Zhang
    College of Plant Protection, Nanjing Agricultural University, Nanjing, China
    PLoS ONE 6:e22874. 2011
    ..This early warning may spur proactive countermeasures, including a switch to transgenic cotton producing two or more toxins distinct from Cry1A toxins...
  88. pmc Biologically meaningful coverage indicators for eliminating malaria transmission
    Samson S Kiware
    Biomedical and Environmental Thematic Group, Ifakara Health Institute, PO Box 53, Ifakara, Tanzania
    Biol Lett 8:874-7. 2012
    ....
  89. pmc Global trends in the use of insecticides to control vector-borne diseases
    Henk van den Berg
    Laboratory of Entomology, Wageningen University, Wageningen, The Netherlands
    Environ Health Perspect 120:577-82. 2012
    ..Data on insecticide use for vector control are essential for guiding pesticide management systems on judicious and appropriate use, resistance management, and reduction of risks to human health and the environment...
  90. pmc Glutathione S-transferases as antioxidant defence agents confer pyrethroid resistance in Nilaparvata lugens
    J G Vontas
    School of Biosciences, Cardiff University, Main College, Museum Avenue, P O Box 915, Cardiff CF10 3TL, Wales, UK
    Biochem J 357:65-72. 2001
    ..Nilaparvata lugens with the pyrethroids permethrin and lambda-cyhalothrin increased its resistance to both insecticides. Biochemical analysis and synergistic studies with metabolic inhibitors indicated that elevated glutathione S-..
  91. pmc Prospects for the development of odour baits to control the tsetse flies Glossina tachinoides and G. palpalis s.l
    J B Rayaisse
    Centre International de Recherche Développement sur l Elevage en zone Subhumide, Bobo Dioulasso, Burkina Faso, United Kingdom
    PLoS Negl Trop Dis 4:e632. 2010
    ....
  92. ncbi Translocation of neonicotinoid insecticides from coated seeds to seedling guttation drops: a novel way of intoxication for bees
    V Girolami
    Dipartimento di Agronomia Ambientale e Produzioni Vegetali, Entomologia, Universita di Padova, Viale dell Universita 16, 35020 Legnaro, Padova, Italy
    J Econ Entomol 102:1808-15. 2009
    ..Although neonicotinoid systemic insecticides used for seed coating of agricultural crops were suspected as possible reason, studies so far have not shown ..
  93. ncbi Poisoning due to pyrethroids
    Sally M Bradberry
    National Poisons Information Service Birmingham Centre, City Hospital, UK
    Toxicol Rev 24:93-106. 2005
    ..Pyrethroids are used widely as insecticides both in the home and commercially, and in medicine for the topical treatment of scabies and headlice...
  94. pmc Development of vegetable farming: a cause of the emergence of insecticide resistance in populations of Anopheles gambiae in urban areas of Benin
    Anges William M Yadouleton
    Centre de Recherche Entomologique de Cotonou, Benin
    Malar J 8:103. 2009
    ..This study aims to assess the rapid expansion of urban agriculture especially, its contribution to the emergence of insecticide resistance in populations of Anopheles gambiae...
  95. pmc A randomized placebo-controlled trial of intermittent preventive treatment in pregnant women in the context of insecticide treated nets delivered through the antenatal clinic
    Clara Menendez
    Barcelona Center for International Health Research CRESIB and Department of Pathology Hospital Clinic, Institut d Investigacions Biomedicas August Pi i Sunyer, Universitat de Barcelona, Barcelona, Spain
    PLoS ONE 3:e1934. 2008
    ..Current recommendations to prevent malaria in African pregnant women rely on insecticide treated nets (ITNs) and intermittent preventive treatment (IPTp). However, there is no information on the safety and efficacy of their combined use...
  96. ncbi Distribution of pyrethroid and DDT resistance and the L1014F kdr mutation in Anopheles gambiae s.l. from Burkina Faso (West Africa)
    K R Dabire
    Insitut de Recherche en Science de la Santé IRSS Centre Muraz, BP 390, Bobo Dioulasso, Burkina Faso
    Trans R Soc Trop Med Hyg 103:1113-20. 2009
    ..The frequency of kdr was also found to have increased in An. arabiensis populations (0.28), where it was formerly reported in only a single specimen. These results have practical significance for malaria vector control programs...
  97. ncbi A mutation in the voltage-gated sodium channel gene associated with pyrethroid resistance in Latin American Aedes aegypti
    K Saavedra-Rodriguez
    Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA
    Insect Mol Biol 16:785-98. 2007
    ..The tools and information presented provide a means for early detection and characterization of kdr that is critical to the development of strategies for resistance management...
  98. pmc Association of in utero organophosphate pesticide exposure and fetal growth and length of gestation in an agricultural population
    Brenda Eskenazi
    Center for Children s Environmental Health Research, School of Public Health, University of California Berkeley, 94720 7380, USA
    Environ Health Perspect 112:1116-24. 2004
    ..However, despite these observed associations, the rate of preterm delivery in this population (6.4%) was lower than in a U.S. reference population...
  99. pmc Insecticide resistance status in Anopheles gambiae in southern Benin
    Anges W Yadouleton
    Centre de Recherche Entomologique de Cotonou CREC, 06 BP 2604 Cotonou, Republique du Benin
    Malar J 9:83. 2010
    ..It is, therefore, crucial to monitor the level and type of insecticide resistance in An. gambiae, particularly in southern Benin where reduced efficacy of insecticide-treated nets (ITNs) and IRS has previously been reported...
  100. pmc Exploring the molecular basis of insecticide resistance in the dengue vector Aedes aegypti: a case study in Martinique Island (French West Indies)
    Sebastien Marcombe
    Laboratoire de Lutte contre les Insectes Nuisibles LIN, Institut de Recherche Pour le Développement IRD Montpellier, France
    BMC Genomics 10:494. 2009
    ..vector control programs are facing operational challenges with mosquitoes becoming resistant to commonly used insecticides. Resistance of Ae...
  101. pmc Household ownership and use of insecticide treated nets among target groups after implementation of a national voucher programme in the United Republic of Tanzania: plausibility study using three annual cross sectional household surveys
    Kara Hanson
    London School of Hygiene and Tropical Medicine, London WC1E 7HT
    BMJ 339:b2434. 2009
    ..To evaluate the impact of the Tanzania National Voucher Scheme on the coverage and equitable distribution of insecticide treated nets, used to prevent malaria, to pregnant women and their infants...

Research Grants68

  1. THE AGRICULTURAL HEALTH STUDY - FIELD STATIONS
    Charles Lynch; Fiscal Year: 2010
    ..Health Study, retinal degeneration was significantly associated with exposure to fungicides and selected insecticides, further analyses are now being conducted...
  2. NIEHS SUPPORT OF THE AHS COHORT STUDY AT NCI
    Charles Knott; Fiscal Year: 2010
    ..Health Study, retinal degeneration was significantly associated with exposure to fungicides and selected insecticides, further analyses are now being conducted...
  3. Lipid glyceryl ester homeostasis in macrophages and perturbation by environmental
    Matthew K Ross; Fiscal Year: 2012
    ..vessel wall macrophages is significantly perturbed by chronic exposure to oxLDL and bioactive metabolites of OP insecticides, and that elevated levels of 2AG and its COX derived metabolite, PGE2-G, modulate cholesterol metabolism in ..
  4. DNA methylation alterations in response to pesticides exposure
    Lifang Hou; Fiscal Year: 2010
    ..Our preliminary data recently linked exposure to organophosphate pesticides (OPs), the most commonly used insecticides in the US, to increased promoter methylation of several tumor suppressor genes in blood DNA...
  5. Genetic Analysis of Mosquito Metamorphosis
    James T Nishiura; Fiscal Year: 2012
    ..We propose to test, by knockdown of gene expression, the hypothesis that the genes broad and methoprene tolerant are central to mosquito development, and are in the pathway by which some insecticides block mosquito development.
  6. IRS insecticides for malaria control and child neurodevelopment in South Africa
    Brenda Eskenazi; Fiscal Year: 2013
    ..use Indoor Residual Spraying (IRS), the application of dichlorodiphenyl trichloroethane (DDT) or pyrethroid insecticides to interior walls of homes, to control malaria...
  7. Olfactory and behavioral responses of kissing bugs (Reduviidae: Triatominae), vec
    John G Hildebrand; Fiscal Year: 2010
    ..Control of Chagas Disease depends mainly on the elimination of vectors through use of residual insecticides and screening of blood banks for infection with T. cruzi...
  8. The function(s) of serpin-2 in mosquito immunity and physiology
    Kristin Michel; Fiscal Year: 2013
    ..In addition to resistance management, novel insecticides with new modes of action - particularly for which efficacy is not affected by existing resistance mechanisms - ..
  9. Transcriptomics and Population Genetics of Mosquito Resistance to Pyrethroids
    Mariangela Bonizzoni; Fiscal Year: 2013
    ..The extensive and multifaceted use of insecticides has led to the emergence and rapid spread of resistance...
  10. Aerosol Delivery of a Recombinant Butyrylcholinesterase "BioShield" to Protect Ag
    YVONNE J ROSENBERG; Fiscal Year: 2012
    ..are potent neurotoxic chemicals that are widely used in medicine, industry and agriculture;most notably as insecticides. The neurotoxicity which is primarily a result of AChE inhibition, may take the form of cholinergic crisis and ..
  11. HEME PROTEIN REDUCTASES
    Stephen G Sligar; Fiscal Year: 2012
    ..of compounds, including cholesterol and steroid structures, long chain alkanes, aromatics, fatty acids, drugs, insecticides, pesticides, critical signaling molecules and carcinogen precursors...
  12. Age and sex effects on nerve agent damage to the brain and antidotal therapies
    Edson X Albuquerque; Fiscal Year: 2010
    ..soman, sarin and VX are organophosphorus compounds (OPs) chemically related to, but far more toxic than OP insecticides. Most of their acute toxicity results from the irreversible inhibition of acetylcholinesterase (AChE), the ..
  13. Training in Molecular and Mechanistic Toxicology
    Edson X Albuquerque; Fiscal Year: 2012
    ..and ecological research applied to such environmental toxicants as metals, phytoestrogens, dioxins, and insecticides, and interests span from basic to clinical and environmental research...
  14. Characterization of the sodium channel mutations involved in insecticide resistan
    Nannan Liu; Fiscal Year: 2011
    ..A major obstacle in controlling these diseases is that mosquitoes have developed resistance to insecticides. The long-term goals of the proposed research are to determine molecular mechanisms that control the mosquito&..
  15. Pope-Presynaptic modulation of anticholinesterase toxicity
    Carey N Pope; Fiscal Year: 2013
    Organophosphorus insecticides (OPs) elicit toxicity by inhibiting acetylcholinesterase, leading to acetylcholine accumulation at cholinergic synapses, excessive stimulation of cholinergic receptors and signs of acute toxicity (e.g...
  16. Regulation of juvenile hormone titers in mosquitoes
    FERNANDO GABRIEL NORIEGA; Fiscal Year: 2013
    ..of mosquito-borne diseases, like malaria and dengue fever, and the wide-spread resistance of mosquitoes to insecticides underscores the need for new approaches for insect control based on mosquito-specific agents...
  17. Development of a Field Applicable Screening Tool (FAST) kit for detecting resista
    MARTIN JAMES DONNELLY; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The long term objective is to facilitate the rational use of insecticides in malaria and filaria control campaigns based by upon a more complete understanding of resistance mechanisms...
  18. The Rosetta Enzyme ReDesign: Targeting PON1 as OP Scavenger
    Jennifer M Bui; Fiscal Year: 2012
    ..OP) compounds are potent cholinesterase inhibitors and have extensively been used as pesticides and insecticides in agriculture, as a flame retardant in plastics and rubbers, and even as a gasoline additive [1-3]...
  19. Molecular Epidemiology of NHL and CLL
    James R Cerhan; Fiscal Year: 2012
    ..including farm practices and exposure to phenoxyacetic acid and triazine herbicides and organophosphate insecticides);3) To evaluate gene-environment interactions in the etiology of NHL, with a focus on the interaction of immune-..
  20. PHYSIOLOGY OF INSECT AMINO ACID TRANSPORT
    Dmitri Y Boudko; Fiscal Year: 2010
    ..The prevention of mosquito-borne diseases with insecticides has been very successful in the past, but it was also recognized as damaging to the environment...
  21. Sustainable Control of Aedes aegypti and epidemic dengue
    Lars Eisen; Fiscal Year: 2013
    ..effectiveness of the Casa Segura to reduce dengue is predicated upon operational effectiveness of pyrethroid insecticides. Knock-down resistance (kdr) to pyrethroids has emerged in Ae...
  22. A highly multiplexed, scalable ultrananocrystalline diamond microarray sensor for
    Donato M Ceres; Fiscal Year: 2013
    ..chemical sensor could potentially be applied to the simultaneous analysis of solutions of heavy metals, EDCs, insecticides, toxins and many other important chemicals in clinical samples...
  23. Efficacy and Safety of an Aerosolized Recombinant Butyrylcholinesterase Pretreatm
    YVONNE J ROSENBERG; Fiscal Year: 2013
    ..are potent neurotoxic chemicals that are widely used in medicine, industry and agriculture;most notably as insecticides. The neurotoxicity which is primarily a result of AChE inhibition, may take the form of cholinergic crisis and ..
  24. MOLECULAR BASIS OF SELECTIVE P450 2B FUNCTION
    James R Halpert; Fiscal Year: 2013
    ..environmental health because it is induced by pesticides and polychlorinated biphenyls (PCBs) and metabolizes insecticides, herbicides, industrial chemicals, solvents, and PCBs...
  25. Functional Genomics of Inversion 2La in Anopheles gambiae
    Nora J Besansky; Fiscal Year: 2013
    ..Aside from the threat of insecticide resistance, existing vector control strategies that focus on indoor use of insecticides may not reach all of the disease-transmitting population or may induce a behavioral shift, given underlying ..
  26. Development of vector-specific, resistance-breaking insecticides to reduce malari
    Paul R Carlier; Fiscal Year: 2013
    ..detoxification;and 5)make a preliminary assessment of mammalian toxicity of the most promising insecticides to emerge from these studies...
  27. PROTECTION AGAINST ORGANOPHOSPHATE NEUROTOXINS BY TOBACCO CEMBRANOIDS
    P A Ferchmin; Fiscal Year: 2010
    ..The risk of OPs exposure is not restricted to war scenario or terrorist attacks but includes industrial leaks of insecticides, accidental poisonings and chronic occupational exposure.
  28. A. gambiae thioester-containing protein 1 (TEP1) protein-protein interactions
    Richard H G Baxter; Fiscal Year: 2011
    ..For instance new insecticides may be developed that kill only mosquitoes infected with malaria, or even compounds that increase the immune ..
  29. Prenatal pyrethroid exposure and child mental, motor and behavioral development
    ROBIN MARJORIE WHYATT; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Exposure to pyrethroid insecticides is a growing health concern due to the ban on residential use of organophosphate (OP) insecticides. Pyrethroids have replaced OP for residential pest control...
  30. Insecticide Resistance in Culex pipiens pallens Mosquitoes
    Changliang Zhu; Fiscal Year: 2013
    ..Due to wide- spread and improper use of insecticides, resistance to pyrethroids is very prevalent in Cx. pipiens mosquito species in China...
  31. Bursicon Receptor Antagonists: Templates for Developing Novel Insecticides
    Alan S Kopin; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The insecticides that are currently used to control populations of disease-transmitting insect vectors act on a highly restricted set of targets...
  32. Mosquito Vector Control Using Bt Coupled to Seed Oil Bodies
    Mohd Amir Abdullah; Fiscal Year: 2009
    ..Bti toxins have strong mosquito species- specific activities, and are safer than chemical insecticides. BtB proteins enhance Bti toxicity by increasing toxin uptake...
  33. Evaluating Hztransib as a potential gene driving mechanism in Anophelene mosquito
    Xianchun Li; Fiscal Year: 2010
    ..Unfortunately the primary control measures, particularly drugs and insecticides, are becoming less effective as resistance emerges in both the parasite and the mosquito vector respectively...
  34. Asthma Exacerbation by Organophosphate Pesticides
    ALLISON DEBORAH FRYER; Fiscal Year: 2011
    ..aims: We will test whether increased sensitivity to OPs extends to the OP class and will include other non OP insecticides as controls (aim1)...
  35. Malaria in Africa: A History of Infections and Interventions, 1900-2010
    JAMES LEWIS ADRIAN WEBB; Fiscal Year: 2012
    ..management programs such as the draining of swamps, the destruction of mosquito habitat, and the use of insecticides and larvicides to kill mosquitoes;the deployment of physical barriers such as screening and bed nets;and the ..
  36. Characterizing the role of the 22 up-regulated genes in mosquito resistance
    Nannan Liu; Fiscal Year: 2010
    ..A major obstacle in controlling these diseases is that mosquitoes have developed resistance to insecticides. Our long-term goals are to determine the roles of genes that control the mosquito's response to ..
  37. Neurobehavioral Effects of Insecticide Exposure in Pregnancy and Early Childhood
    Kimberly Yolton; Fiscal Year: 2010
    The objective of this study is to examine the effects of exposure to prevalent insecticides on neurobehavioral outcomes in a cohort of 399 children...
  38. Role of the DSC1 family of cation channels in insect neurophysiology and neurotox
    Chun Fang Wu; Fiscal Year: 2012
    Use of insecticides and repellents to control insect vectors is an important strategy for fighting some of the most devestating human diseases, such as malaria...
  39. Malaria Vector Population Genetic Division and Vector Competence in Hainan Island
    Liwang Cui; Fiscal Year: 2013
    ..In Hainan Island of China, extensive use of insecticides for malaria control has led to an initially sharp decrease and recently rebound of Anopheles miminus, the key ..
  40. Ecdysteroid Signaling in Filarial Parasites
    Thomas R Unnasch; Fiscal Year: 2013
    ..The success in developing highly effective EcR analog insecticides which are non-toxic to off-target organisms underscores the potential of the EcR as a chemotherapeutic target ..
  41. Validation of carbamate pesticide screen for VetLIRN network
    ROBERT HOWARD POPPENGA; Fiscal Year: 2013
    ..Carbamates are highly toxic insecticides, with current pesticide use registrations. They are found both in agricultural and home environments...
  42. Role of monoacylglycerol lipase in coordinating diverse lipid signaling pathways
    DANIEL KOJI NOMURA; Fiscal Year: 2010
    ..Prof John Casida focused on elucidating off-targets of organophosphorus (OP) nerve agents that are used as insecticides and chemical warfare agents...
  43. Biomarkers of Organophosphate-Adducted Proteins
    CHARLES MARK THOMPSON; Fiscal Year: 2010
    ..Over 100 million pounds of OP insecticides are used each year but lead to over 25,000 reports to poison control centers each year including 10,000 ..
  44. Functional and transcriptional profiling of lice defenses against pediculicides
    JOHN MARSHALL CLARK; Fiscal Year: 2010
    ..variation and allows the efficient identification of inducible detox genes involved in the metabolism of these insecticides, providing temporary protection termed "tolerance...
  45. Increasing potency of attenuated sporozoite vaccines with a glycolipid adjuvant
    STEPHEN LEV HOFFMAN; Fiscal Year: 2012
    ..a. caused by Plasmodium falciparum (Pf) malaria. Control using bednets, insecticides, and drugs, has been significant but as stressed recently in The Lancet editorial, a malaria vaccine is needed...
  46. Reducing malaria transmission with engineered bacteria
    David J Lampe; Fiscal Year: 2011
    ..provided by applicant): The fight against the intolerable burden of malaria is restricted to the use of insecticides that kill the mosquito vector and drugs that kill the parasite in humans...
  47. Pyrethroid Resistance in Malaria Mosquito Anopheles sinensis
    Bin Chen; Fiscal Year: 2012
    ..The insecticides of choice for bed nets and indoor-residual spray are pyrethroids because of their high efficacy, rapid rate of ..
  48. Role of monoacylglycerol lipase in coordinating diverse lipid signaling pathways
    DANIEL KOJI NOMURA; Fiscal Year: 2013
    ..Prof John Casida focused on elucidating off-targets of organophosphorus (OP) nerve agents that are used as insecticides and chemical warfare agents...
  49. Molecular Targets for Control of Vector-Borne Diseases: Bridging Lab and Field R
    Andrew D Robertson; Fiscal Year: 2010
    ..vector researchers has been developing new ways to utilize existing vector control tools such as bednets and insecticides that, if consistently implemented, can yield impressive outcomes...
  50. Development of a Drosophila model to study vector colonization by Yersinia pestis
    MELANIE MARKETON; Fiscal Year: 2013
    ..to the resurgence of many vector-borne diseases is the resistance to antimicrobials, pesticides and insecticides. In order to develop new counter-measures, we must identify new targets that disrupt the transmission cycle for ..
  51. Preventing exposure to ticks and tick-borne illness in outdoor workers
    STEVEN RICHARD MESHNICK; Fiscal Year: 2013
    ..Currently, tick-bite prevention requires time- consuming reapplication of insecticides to clothing and exposed skin. Unfortunately, adherence to these procedures is poor...
  52. A Plant-Derived Recombinant Bioscavenger to Prevent Insecticide Neurotoxicity
    Yvonne Rosenberg; Fiscal Year: 2007
    ..are potent neurotoxic chemicals that are widely used in medicine, industry and agriculture; most notably as insecticides. The neurotoxicity may take the form of cholinergic crisis and death as a consequence of acute exposure or ..
  53. POPULATION GENETICS OF AEDES AEGYPTI IN THE WEST INDIES
    David Severson; Fiscal Year: 1999
    ..is a prevalent infection in tropical areas and the only measures against this disease are vector elimination by insecticides, an approach that has not been entirely successful...
  54. Central Cholinergic System, Its History &Current Status
    ALEXANDER KARCZMAR; Fiscal Year: 2002
    ..A Chapter on anticholinesterase agents will stress their economic importance as insecticides and pesticides, as well as the significant toxicological and environmental consequences of their use; it will ..
  55. Center for the Study of Complex Malaria in India
    Jane M Carlton; Fiscal Year: 2013
    ..ecological and evolutionary determinants of malaria transmission, and the efficacy of novel evolution-proof bio-insecticides for disrupting transmission of simple and complex malaria...
  56. Mixture Modeling: Pesticide Drug Interactions
    Charles Timchalk; Fiscal Year: 2009
    ..additional risk) that smoking and alcohol consumption has on agricultural workers who are routinely exposed to insecticides. Drug/chemical interactions share a common theme in which pharmacokinetic and pharmacodynamic responses are ..
  57. GABAERGIC INSECTICIDE TOXICOLOGY
    JOHN CASIDA; Fiscal Year: 2002
    The long-term objective is to define the fundamental basis for the selective toxicity of insecticides acting at the gamma-aminobutyric acid (GABA) receptor of mammals and insects...
  58. FUNCTIONAL ANALYSIS OF NOVEL GABA RECEPTOR IN DROSOPHILA
    Richard ffrench Constant; Fiscal Year: 1999
    ..gene Rdl (Resistance to dieldrin) that was cloned from a Drosophila mutant resistant to PTX and cyclodiene insecticides. He has functionally expressed in Xenopus oocytes GABA-gated chloride channels composed of homomultimers of Rdl ..
  59. Targeting the reproductive interactome of the malaria vector Anopheles gambiae
    Flaminia Catteruccia; Fiscal Year: 2013
    ..In the absence of an effective malaria vaccine, chemical control of the mosquito vector through the use of insecticides remains the best weapon to fight malaria transmission...
  60. Engineering the genetics of wild mosquito populations to fight infectious disease
    Bruce A Hay; Fiscal Year: 2011
    ..approaches to disease prevention, which include anti-pathogen drugs and vector suppression through the use of insecticides or environment modification, are insufficient...
  61. A NEW BIOSENSOR BASED ON CATASTROPHIC PROTEIN CHANGES
    CHARLES MARK THOMPSON; Fiscal Year: 2010
    ..are 150,000 and 300,000 toxicity incidences reported yearly in the US for exposure to organophosphate (OP) insecticides and millions treated worldwide...
  62. Engineering the genetics of wild mosquito populations to fight infectious disease
    Bruce A Hay; Fiscal Year: 2012
    ..approaches to disease prevention, which include anti-pathogen drugs and vector suppression through the use of insecticides or environment modification, are insufficient...
  63. Molecular mechanisms of action and resistance of sodium channel-targeting insecti
    Boris Zhorov; Fiscal Year: 2013
    ..of this research is to understand the molecular action and resistance mechanisms of two important classes of insecticides, pyrethroids and sodium channel blocker insecticides (SCBIs)...
  64. Building motif lexicons
    Martin R Schiller; Fiscal Year: 2010
    ..cause human disease and to identify putative targets for the development of therapeutic drugs, antibiotics, insecticides, and antiviral agents...
  65. Naturally Occurring Agent for Alcohol Liver Diseases
    YUE WEI LEE; Fiscal Year: 2003
    ..propose to (1) conduct field inspection of the collection, processing, extraction, and contamination control (insecticides, herbicides, and chemical fertilizers) of the seed of Milk Thistle; (2) optimize the analytical HPLC conditions ..
  66. Control of Urban and Peri-urban Culex Mosquitoes
    Gregory Lanzaro; Fiscal Year: 2007
    ..goal is to improve strategies to control Culex mosquitoes by modifying methods for the application of chemical insecticides, developing novel methods for monitoring metabolic resistance to these insecticides and the development of ..
  67. HYDROLYTIC ENZYMES IN THE METABOLISM OF TOXINS
    Bruce Hammock; Fiscal Year: 2007
    ..advances understanding enzyme catalysis and inhibition by several compounds including commercial herbicides and insecticides. The message and gene are being used to determine the basis of the unique dual localization of the sEH in ..
  68. Catalytic definition of insecticide-metabolizing P450s
    MARY SCHULER; Fiscal Year: 2007
    ..applicant): Insects are continually exposed to an array of natural toxic plant chemicals and synthetic toxic insecticides that are used in the management of insects vectoring human and animal diseases and damaging crops...