herbicides

Summary

Summary: Pesticides used to destroy unwanted vegetation, especially various types of weeds, grasses (POACEAE), and woody plants.

Top Publications

  1. ncbi River loads of suspended solids, nitrogen, phosphorus and herbicides delivered to the Great Barrier Reef lagoon
    Frederieke J Kroon
    CSIRO Ecosystem Sciences, P O Box 780, Atherton, QLD 4883, Australia
    Mar Pollut Bull 65:167-81. 2012
  2. ncbi Evolution in action: plants resistant to herbicides
    Stephen B Powles
    Western Australian Herbicide Resistance Initiative, School of Plant Biology, University of Western Australia, Crawley, WA, Australia
    Annu Rev Plant Biol 61:317-47. 2010
  3. ncbi Glyphosate: a once-in-a-century herbicide
    Stephen O Duke
    USDA ARS, Natural Products Utilization Research Unit, National Center for Natural Products Research, PO Box 8048, University, MS 38677, USA
    Pest Manag Sci 64:319-25. 2008
  4. pmc Structural basis of cyanobacterial photosystem II Inhibition by the herbicide terbutryn
    Matthias Broser
    Institut für Chemie Max Volmer Laboratorium für Biophysikalische Chemie, Technische Universitat Berlin, Berlin, Germany
    J Biol Chem 286:15964-72. 2011
  5. ncbi Paraquat poisonings: mechanisms of lung toxicity, clinical features, and treatment
    R J Dinis-Oliveira
    REQUIMTE, Departamento de Toxicologia, Faculdade de Farmacia, Universidade do Porto, Porto, Portugal
    Crit Rev Toxicol 38:13-71. 2008
  6. ncbi Mechanism of resistance of evolved glyphosate-resistant Palmer amaranth (Amaranthus palmeri)
    Todd A Gaines
    Department of Bioagricultural Sciences and Pest Management, Colorado State University, 1177 Campus Delivery, Fort Collins, Colorado 80523, USA
    J Agric Food Chem 59:5886-9. 2011
  7. pmc A geographic information system for characterizing exposure to Agent Orange and other herbicides in Vietnam
    Jeanne Mager Stellman
    Department of Health Policy and Management, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
    Environ Health Perspect 111:321-8. 2003
  8. pmc Phenoxy herbicides and chlorophenols: a case control study on soft tissue sarcoma and malignant lymphoma
    J G Smith
    Statistical Centre, Peter MacCallum Cancer Institute, Melbourne, Victoria, Australia
    Br J Cancer 65:442-8. 1992
  9. ncbi The MEP pathway: a new target for the development of herbicides, antibiotics and antimalarial drugs
    M Rodriguez-Concepcion
    Department de Bioquimica i Biologia Molecular, Facultat de Quimica, Universidad de Barcelona, Barcelona, Spain
    Curr Pharm Des 10:2391-400. 2004
  10. ncbi Non-target-site herbicide resistance: a family business
    Joshua S Yuan
    Department of Plant Sciences, University of Tennessee, Knoxville, TN 37996, USA
    Trends Plant Sci 12:6-13. 2007

Detail Information

Publications350 found, 100 shown here

  1. ncbi River loads of suspended solids, nitrogen, phosphorus and herbicides delivered to the Great Barrier Reef lagoon
    Frederieke J Kroon
    CSIRO Ecosystem Sciences, P O Box 780, Atherton, QLD 4883, Australia
    Mar Pollut Bull 65:167-81. 2012
    ..7 times to 80,000tonnes/year, (iii) total phosphorus by 8.9 times to 16,000tonnes/year, and (iv) PSII herbicides is 30,000kg/year...
  2. ncbi Evolution in action: plants resistant to herbicides
    Stephen B Powles
    Western Australian Herbicide Resistance Initiative, School of Plant Biology, University of Western Australia, Crawley, WA, Australia
    Annu Rev Plant Biol 61:317-47. 2010
    Modern herbicides make major contributions to global food production by easily removing weeds and substituting for destructive soil cultivation...
  3. ncbi Glyphosate: a once-in-a-century herbicide
    Stephen O Duke
    USDA ARS, Natural Products Utilization Research Unit, National Center for Natural Products Research, PO Box 8048, University, MS 38677, USA
    Pest Manag Sci 64:319-25. 2008
    ..Adoption of resistance management practices will be required to maintain the benefits of glyphosate technologies for future generations...
  4. pmc Structural basis of cyanobacterial photosystem II Inhibition by the herbicide terbutryn
    Matthias Broser
    Institut für Chemie Max Volmer Laboratorium für Biophysikalische Chemie, Technische Universitat Berlin, Berlin, Germany
    J Biol Chem 286:15964-72. 2011
    b>Herbicides that target photosystem II (PSII) compete with the native electron acceptor plastoquinone for binding at the Q(B) site in the D1 subunit and thus block the electron transfer from Q(A) to Q(B)...
  5. ncbi Paraquat poisonings: mechanisms of lung toxicity, clinical features, and treatment
    R J Dinis-Oliveira
    REQUIMTE, Departamento de Toxicologia, Faculdade de Farmacia, Universidade do Porto, Porto, Portugal
    Crit Rev Toxicol 38:13-71. 2008
    ..Considerable space is also dedicated to techniques for prognosis prediction, since these could allow development of rigorous clinical protocols that may produce comparable data for the evaluation of proposed therapies...
  6. ncbi Mechanism of resistance of evolved glyphosate-resistant Palmer amaranth (Amaranthus palmeri)
    Todd A Gaines
    Department of Bioagricultural Sciences and Pest Management, Colorado State University, 1177 Campus Delivery, Fort Collins, Colorado 80523, USA
    J Agric Food Chem 59:5886-9. 2011
    ..Questions remain related to how the EPSPS amplification initially occurred and the occurrence of this mechanism in other Palmer amaranth populations and other glyphosate-resistant species...
  7. pmc A geographic information system for characterizing exposure to Agent Orange and other herbicides in Vietnam
    Jeanne Mager Stellman
    Department of Health Policy and Management, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
    Environ Health Perspect 111:321-8. 2003
    ..for carrying out epidemiologic research, a conceptual framework for estimating exposure opportunity to herbicides and a geographic information system (GIS) have been developed...
  8. pmc Phenoxy herbicides and chlorophenols: a case control study on soft tissue sarcoma and malignant lymphoma
    J G Smith
    Statistical Centre, Peter MacCallum Cancer Institute, Melbourne, Victoria, Australia
    Br J Cancer 65:442-8. 1992
    ..to test whether there was any association between these diseases and past exposure to chlorinated phenoxy acid herbicides or chlorophenols. It was carried out over the period 1982-1988 in Victoria, Australia...
  9. ncbi The MEP pathway: a new target for the development of herbicides, antibiotics and antimalarial drugs
    M Rodriguez-Concepcion
    Department de Bioquimica i Biologia Molecular, Facultat de Quimica, Universidad de Barcelona, Barcelona, Spain
    Curr Pharm Des 10:2391-400. 2004
    ..of MEP pathway enzymes (which are highly conserved but show no homology to mammalian proteins) should result in herbicides and drugs with broad-spectrum antimicrobial activity without mechanism-based toxicity to humans...
  10. ncbi Non-target-site herbicide resistance: a family business
    Joshua S Yuan
    Department of Plant Sciences, University of Tennessee, Knoxville, TN 37996, USA
    Trends Plant Sci 12:6-13. 2007
    ..To further understand the mechanisms of non-target-site resistance, we propose an integrated genomics approach to dissect systematically the functional genomics of four gene families in economically important weed species...
  11. pmc Modifications of cellulose synthase confer resistance to isoxaben and thiazolidinone herbicides in Arabidopsis Ixr1 mutants
    W R Scheible
    Department of Plant Biology, Carnegie Institution, Stanford, CA 94305-4150, USA
    Proc Natl Acad Sci U S A 98:10079-84. 2001
    In many higher plants, cellulose synthesis is inhibited by isoxaben and thiazolidinone herbicides such as 5-tert-butyl-carbamoyloxy-3-(3-trifluromethyl) phenyl-4-thiazolidinone...
  12. ncbi Optical biosensors for environmental monitoring based on computational and biotechnological tools for engineering the photosynthetic D1 protein of Chlamydomonas reinhardtii
    Maria Teresa Giardi
    Institute of Crystallography, Area of Research of Rome, Department of Agrofood, CNR, Via Salaria km 29 300, 00015, Monterotondo Scalo, Rome, Italy
    Biosens Bioelectron 25:294-300. 2009
    ..identify functional amino acids in the D1 protein of the photosynthetic electron transfer chain interacting with herbicides. A library of functional mutations in the unicellular green alga Chlamydomonas reinhardtii for preparing ..
  13. pmc Postmortem analyses unveil the poor efficacy of decontamination, anti-inflammatory and immunosuppressive therapies in paraquat human intoxications
    Ricardo Jorge Dinis-Oliveira
    Faculty of Medicine, University of Porto, Porto, Portugal
    PLoS ONE 4:e7149. 2009
    ....
  14. ncbi Prevalence of cross- or multiple resistance to the acetyl-coenzyme A carboxylase inhibitors fenoxaprop, clodinafop and pinoxaden in black-grass (Alopecurus myosuroides Huds.) in France
    Cécile Petit
    INRA, UMR 1210 Biologie et Gestion des Adventices, F 21000 Dijon, France
    Pest Manag Sci 66:168-77. 2010
    ..We investigated pinoxaden resistance conferred by five mutant ACCase isoforms. Using 84 French black-grass field samples, we also compared the frequencies of other mechanisms endowing resistance to fenoxaprop, clodinafop or pinoxaden...
  15. ncbi Nitric oxide in paraquat-mediated toxicity: A review
    Jose M Moran
    Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas CIBERNED, Departamento de Bioquímica y Biología Moleculary Genética, EU Enfermería y TO, Universidad de Extremadura, Avda Universidad s n 10071 Cáceres, Spain
    J Biochem Mol Toxicol 24:402-9. 2010
    ..The present review summarizes recent findings in the field and describes new knowledge on the role of nitric oxide in the paraquat-mediated toxicity...
  16. pmc Medical management of paraquat ingestion
    Indika B Gawarammana
    Department of Medicine, Faculty of Medicine, University of Peradeniya, Peradeniya, Sri Lanka
    Br J Clin Pharmacol 72:745-57. 2011
    ..However, there are no published human trials. The case fatality is very high in all centres despite large variations in treatment...
  17. pmc TCDD and cancer: a critical review of epidemiologic studies
    Paolo Boffetta
    International Prevention Research Institute, Lyon, France
    Crit Rev Toxicol 41:622-36. 2011
    ..The emphasis on results for overall cancer risk-rather than risk for specific neoplasms-is not justified on epidemiologic grounds and is not a reason for ignoring the weaknesses of the available evidence...
  18. ncbi Exposure to pesticides as risk factor for non-Hodgkin's lymphoma and hairy cell leukemia: pooled analysis of two Swedish case-control studies
    Lennart Hardell
    Department of Oncology, Orebro University Hospital, Sweden
    Leuk Lymphoma 43:1043-9. 2002
    ..Increased risks in univariate analysis were found for subjects exposed to herbicides (OR 1.75, CI 95% 1.26-2.42), insecticides (OR 1.43, CI 95% 1.08-1.87), fungicides (OR 3.11, CI 95% 1.56-6...
  19. pmc Molecular bases for sensitivity to tubulin-binding herbicides in green foxtail
    Christophe Délye
    Institut National de la Recherche Agronomique, Unité Mixte de Recherche Biologie et Gestion des Adventices, F 21065 Dijon Cedex, France
    Plant Physiol 136:3920-32. 2004
    We investigated the molecular bases for resistance to several classes of herbicides that bind tubulins in green foxtail (Setaria viridis L. Beauv.). We identified two alpha- and two beta-tubulin genes in green foxtail...
  20. ncbi Paraquat poisoning
    Chanchai Sittipunt
    Department of Internal Medicine, Chulalongkorn University School of Medicine, Bangkok, Thailand
    Respir Care 50:383-5. 2005
  21. ncbi Cooperative catabolic pathways within an atrazine-degrading enrichment culture isolated from soil
    Daniel Smith
    Department of Environmental Sciences, University of California, Riverside, 92521, USA
    FEMS Microbiol Ecol 53:265-73. 2005
    ..The analysis of this enrichment culture highlights the broad level bacterial community interactions that may be involved in atrazine degradation in nature...
  22. ncbi Why have no new herbicide modes of action appeared in recent years?
    Stephen O Duke
    Agricultural Research Service, Natural Products Utilization Research Unit, United States Department of Agriculture, University of Mississippi, Oxford, MS, USA
    Pest Manag Sci 68:505-12. 2012
    b>Herbicides with new modes of action are badly needed to manage the evolution of resistance of weeds to existing herbicides. Yet no major new mode of action has been introduced to the market place for about 20 years...
  23. ncbi Herbicide resistance and supersensitivity in photosystem II
    W Oettmeier
    Lehrstuhl Biochemie der Pflanzen, Ruhr Universitat, Bochum, Germany
    Cell Mol Life Sci 55:1255-77. 1999
    Resistance to triazine herbicides in higher plants was first observed in 1970. A mutation in the photosystem II reaction center D1 protein at position Ser264 --> Gly is responsible for this resistance...
  24. ncbi Plasma surfactant D in patients following acute paraquat intoxication
    Hyo Wook Gil
    Department of Internal Medicine, Soonchunhyang, University Cheonan Hospital, Cheonan, Republic of Korea
    Clin Toxicol (Phila) 45:463-7. 2007
    ..384, p = 0.003, N = 57). SP-D did not predict the likelihood of survival, but it was positively correlated with PaO(2). This finding suggests that low concentrations of plasma SP-D could reflect hypoxia due to free radical-induced injury...
  25. ncbi Agrochemicals increase trematode infections in a declining amphibian species
    Jason R Rohr
    Biology Department, University of South Florida, Tampa, Florida 33620, USA
    Nature 455:1235-9. 2008
    ....
  26. pmc Modes of action of microbially-produced phytotoxins
    Stephen O Duke
    United States Department of Agriculture, Agricultural Research Service, Natural Products Utilization Research Unit, P O Box 8048, MS 38677, USA
    Toxins (Basel) 3:1038-64. 2011
    ..A few of these share molecular target sites with some synthetic herbicides, but many microbial toxins have unique target sites with potential for exploitation by the herbicide industry...
  27. ncbi Characterization of the horseweed (Conyza canadensis) transcriptome using GS-FLX 454 pyrosequencing and its application for expression analysis of candidate non-target herbicide resistance genes
    Yanhui Peng
    Department of Plant Sciences, University of Tennessee, Knoxville, TN USA
    Pest Manag Sci 66:1053-62. 2010
    ..However, available sequence data for this species are scant. The transcriptomic sequence should be useful for gene discovery, and to help elucidate the non-target-based glyphosate resistance mechanism and the genomic basis of weediness...
  28. ncbi Gestational atrazine exposure: effects on male reproductive development and metabolite distribution in the dam, fetus, and neonate
    Melanie J P Fraites
    Endocrine Toxicology Branch, Toxicity Assessment Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, NC 27711, United States
    Reprod Toxicol 32:52-63. 2011
    ..We conclude that, although levels of chlorotriazines within the fetus were considerable, gestational exposures of 1-20mg/kg-d do not lead to alterations in the measures of male development examined in this study...
  29. ncbi Geographical variation in resistance to acetyl-coenzyme A carboxylase-inhibiting herbicides across the range of the arable weed Alopecurus myosuroides (black-grass)
    Christophe Délye
    INRA, UMR1210 Biologie et Gestion des Adventices, Dijon, France
    New Phytol 186:1005-17. 2010
    The geographical structure of resistance to herbicides inhibiting acetyl-coenzyme A carboxylase (ACCase) was investigated in the weed Alopecurus myosuroides (black-grass) across its geographical range to gain insight into the process of ..
  30. ncbi An aspartate to glycine change in the carboxyl transferase domain of acetyl CoA carboxylase and non-target-site mechanism(s) confer resistance to ACCase inhibitor herbicides in a Lolium multiflorum population
    Shiv Shankhar Kaundun
    Syngenta, Jealott s Hill International Research Centre, Bracknell, Berkshire, UK
    Pest Manag Sci 66:1249-56. 2010
    The increasing use of ACCase-inhibiting herbicides has resulted in evolved resistance in key grass weeds infesting cereal cropping systems worldwide...
  31. pmc Cancer incidence of 2,4-D production workers
    Carol Burns
    The Dow Chemical Company, Epidemiology, 1803 Building, Midland, MI 48674, USA
    Int J Environ Res Public Health 8:3579-90. 2011
    ..57-0.94), and "other respiratory" cancers (SIR = 3.79, 95% CI 1.22-8.84; 4 of 5 cases were mesotheliomas). Overall, we observed fewer cancer cases than expected, and a non statistically significant increase in the number of NHL cases...
  32. pmc Urinary biomarkers of prenatal atrazine exposure and adverse birth outcomes in the PELAGIE birth cohort
    Cécile Chevrier
    INSERM, U625, Rennes, France
    Environ Health Perspect 119:1034-41. 2011
    ..Despite evidence of atrazine toxicity in developing organisms from experimental studies, few studies--and fewer epidemiologic investigations--have examined the potential effects of prenatal exposure...
  33. ncbi [Cytotoxicity of the herbicide glyphosate in human peripheral blood mononuclear cells]
    Adriano Martínez
    Corporación Universitaria Rafael Núñez, Cartagena, Colombia
    Biomedica 27:594-604. 2007
    ..Studies evaluating glyphosate toxicity in animals and environment show that commercial formulations of glyphosate are more toxic than the active component itself...
  34. ncbi Paraquat and Parkinson's disease
    C Berry
    Queen Mary, University of London, London, E1 4NS, UK
    Cell Death Differ 17:1115-25. 2010
    ..This review critically analyses the evidence that implicates PQ in parkinsonism and discusses the limitations of chemical modelling of PD...
  35. ncbi The extent and patterns of usage of Agent Orange and other herbicides in Vietnam
    Jeanne Mager Stellman
    Department of Health Policy and Management, Mailman School of Public Health, Columbia University, 600 West 168th Street, New York, New York 10032, USA
    Nature 422:681-7. 2003
    b>Herbicides including Agent Orange were sprayed by United States forces for military purposes during the Vietnam War (1961-1971) at a rate more than an order of magnitude greater than for similar domestic weed control...
  36. pmc Molecular bases for sensitivity to acetyl-coenzyme A carboxylase inhibitors in black-grass
    Christophe Délye
    Institut National de la Recherche Agronomique, Unite Mixte de Recherche, Biologie et Gestion des Adventices, F 21065 Dijon Cedex, France
    Plant Physiol 137:794-806. 2005
    ..The three-dimensional shape of this cavity is thus likely of high importance for the efficacy of ACCase inhibitors...
  37. pmc Complete nucleotide sequence and organization of the atrazine catabolic plasmid pADP-1 from Pseudomonas sp. strain ADP
    B Martinez
    Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, St Paul, Minnesota 55108, USA
    J Bacteriol 183:5684-97. 2001
    ..These results begin to provide insight into how plasmids are structured, and thus evolve, to encode the catabolism of compounds recently added to the biosphere...
  38. pmc Mortality in New Zealand workers exposed to phenoxy herbicides and dioxins
    A 't Mannetje
    Centre for Public Health Research, Research School of Public Health, Massey University Wellington Campus, PO Box 756, Wellington, New Zealand
    Occup Environ Med 62:34-40. 2005
    ..To evaluate mortality in New Zealand phenoxy herbicide producers and sprayers exposed to dioxins...
  39. pmc Interaction of the herbicide glyphosate with its target enzyme 5-enolpyruvylshikimate 3-phosphate synthase in atomic detail
    E Schonbrunn
    Department of Medicinal Chemistry, University of Kansas, Lawrence, KS 66045, USA
    Proc Natl Acad Sci U S A 98:1376-80. 2001
    ..microbes relies on the enzyme 5-enolpyruvylshikimate 3-phosphate (EPSP) synthase, a prime target for drugs and herbicides. We have identified the interaction of EPSP synthase with one of its two substrates (shikimate 3-phosphate) and ..
  40. pmc A gain-of-function mutation in the Arabidopsis pleiotropic drug resistance transporter PDR9 confers resistance to auxinic herbicides
    Hironori Ito
    Department of Plant Biology, University of Minnesota Twin Cities, St Paul, 55108, USA
    Plant Physiol 142:63-74. 2006
    ..The single amino acid change results in increased PDR9 abundance and provides a novel approach for elucidating the function of plant PDR proteins...
  41. ncbi The current status and environmental impacts of glyphosate-resistant crops: a review
    Antonio L Cerdeira
    Brazilian Department of Agriculture, Agricultural Research Service, Embrapa Environment, C P 69, Jaguariuna SP 13820 000, Brazil
    J Environ Qual 35:1633-58. 2006
    ..Effects of glyphosate on contamination of soil, water, and air are minimal, compared to some of the herbicides that they replace...
  42. ncbi Cytochromes P450 for engineering herbicide tolerance
    D Werck-Reichhart
    Dept of Cellular and Molecular Enzymology, Institute of Plant Molecular Biology, Centre National de la Recherche Scientifique UPR 406, 28 rue Goethe, 67083 Strasbourg Cedex, France
    Trends Plant Sci 5:116-23. 2000
    ....
  43. pmc Atrazine induces complete feminization and chemical castration in male African clawed frogs (Xenopus laevis)
    Tyrone B Hayes
    Laboratory for Integrative Studies in Amphibian Biology, Department of Integrative Biology, University of California, Berkeley, CA 94720 3140, USA
    Proc Natl Acad Sci U S A 107:4612-7. 2010
    ..These data are consistent with effects of atrazine observed in other vertebrate classes. The present findings exemplify the role that atrazine and other endocrine-disrupting pesticides likely play in global amphibian declines...
  44. pmc Microglial activation as a priming event leading to paraquat-induced dopaminergic cell degeneration
    Maya G Purisai
    The Parkinson s Institute, 1170 Morse Avenue, Sunnyvale, CA 94089, USA
    Neurobiol Dis 25:392-400. 2007
    ..Data indicate that microglial activation and consequent induction of NADPH oxidase may act as risk factors for Parkinson's disease by increasing the vulnerability of dopaminergic cells to toxic injury...
  45. ncbi A novel mechanism of nuclear photosynthesis gene regulation by redox signals from the chloroplast during photosystem stoichiometry adjustment
    T Pfannschmidt
    Institute of General Botany, Department of Plant Physiology, University of Jena, Dornburger Strasse 159, 07743 Jena, Germany
    J Biol Chem 276:36125-30. 2001
    ..Thus, the expression of nuclear-encoded PSI genes is controlled by diverse light quality-dependent redox signals from the plastids during photosystem stoichiometry adjustment...
  46. ncbi Auxin herbicides induce H(2)O(2) overproduction and tissue damage in cleavers (Galium aparine L.)
    K Grossmann
    BASF Agricultural Center Limburgerhof, D 67114 Limburgerhof, Germany
    J Exp Bot 52:1811-6. 2001
    The phytotoxic effects of auxin herbicides, including the quinoline carboxylic acids quinmerac and quinclorac, the benzoic acid dicamba and the pyridine carboxylic acid picloram, were studied in relation to changes in phytohormonal ..
  47. ncbi Paraquat induces dopaminergic dysfunction and proteasome impairment in DJ-1-deficient mice
    Wonsuk Yang
    Department of Neurology, The University of Chicago, IL 60637, USA
    Hum Mol Genet 16:2900-10. 2007
    ..In conclusion, this study raises the possibility that environmental and genetic factors might cooperatively involve the mechanisms underlying proteasome impairment in PD brains...
  48. ncbi Herbicide-induced oxidative stress in photosystem II
    A W Rutherford
    Section de Bioenergetique, DBCM, CEA CNRS URA 2096, CE Saclay, 91191, Gif sur Yvette, France
    Trends Biochem Sci 26:648-53. 2001
    Some herbicides act by binding to the exchangeable quinone site in the photosystem II (PSII) reaction centre, thus blocking electron transfer...
  49. pmc An exploratory analysis of the effect of pesticide exposure on the risk of spontaneous abortion in an Ontario farm population
    T E Arbuckle
    Bureau of Reproductive and Child Health, Population and Public Health Branch, Health Canada, Ottawa, Ontario, Canada
    Environ Health Perspect 109:851-7. 2001
    ..We observed moderate increases in risk of early abortions for preconception exposures to phenoxy acetic acid herbicides [odds ratio (OR) = 1.5; 95% confidence interval (CI), 1.1-2.1], triazines (OR = 1.4; 95% CI, 1.0-2...
  50. pmc Diversity of acetyl-coenzyme A carboxylase mutations in resistant Lolium populations: evaluation using clethodim
    Qin Yu
    Western Australian Herbicide Resistance Initiative, School of Plant Biology, University of Western Australia, Crawley, Western Australia 6009, Australia
    Plant Physiol 145:547-58. 2007
    ..populations we revealed diversity and complexity in the molecular basis of resistance to ACCase-inhibiting herbicides (clethodim in particular)...
  51. pmc Biosynthesis of phosphonic and phosphinic acid natural products
    William W Metcalf
    Department of Microbiology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Annu Rev Biochem 78:65-94. 2009
    ..These investigations have also suggested new strategies for natural product discovery...
  52. pmc A codon deletion confers resistance to herbicides inhibiting protoporphyrinogen oxidase
    William L Patzoldt
    Department of Crop Sciences, University of Illinois, Urbana, IL 61801, USA
    Proc Natl Acad Sci U S A 103:12329-34. 2006
    b>Herbicides that act by inhibiting protoporphyrinogen oxidase (PPO) are widely used to control weeds in a variety of crops...
  53. ncbi Unravelling the genetic bases of non-target-site-based resistance (NTSR) to herbicides: a major challenge for weed science in the forthcoming decade
    Christophe Délye
    INRA, UMR1347 Agroécologie, Dijon, France
    Pest Manag Sci 69:176-87. 2013
    Non-target-site-based resistance (NTSR) can confer unpredictable cross-resistance to herbicides. However, the genetic determinants of NTSR remain poorly known...
  54. ncbi Mobility and leaching of glyphosate: a review
    Harry Vereecken
    Agrosphere Institute, Institute for Chemistry and Dynamics of the Geosphere, Forschungszentrum Julich GmbH, D52428 Jülich, Germany
    Pest Manag Sci 61:1139-51. 2005
    ..Concentrations of glyphosate in European groundwater have been reported occasionally but monitoring is still limited...
  55. pmc Broad resistance to ACCase inhibiting herbicides in a ryegrass population is due only to a cysteine to arginine mutation in the target enzyme
    Shiv Shankhar Kaundun
    Syngenta, Jealott s Hill International Research Centre, Biological Sciences, Bracknell, United Kingdom
    PLoS ONE 7:e39759. 2012
    ..weed management strategies requires a good understanding of the mechanisms by which weeds evolve resistance to herbicides. Here we have conducted a study on the mechanism of resistance to ACCase inhibiting herbicides in a Lolium ..
  56. pmc In vitro cytotoxic effect of glyphosate mixture containing surfactants
    Ho Yeon Song
    Department of Immunology, Soonchunhyang University College of Medicine, Cheonan, Korea
    J Korean Med Sci 27:711-5. 2012
    ..1% ± 3.4% vs 39.0% ± 0.7%) were compared to that of LN-10 alone. These results suggest that the mixture toxicity may be a factor in glyphosate-surfactant toxicity in patients with acute glyphosate herbicide intoxication...
  57. ncbi Flavodoxin overexpression confers tolerance to oxidative stress in beneficial soil bacteria and improves survival in the presence of the herbicides paraquat and atrazine
    T Coba de la Peña
    Instituto de Ciencias Agrarias, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    J Appl Microbiol 115:236-46. 2013
    To determine whether expression of a cyanobacterial flavodoxin in soil bacteria of agronomic interest confers protection against the widely used herbicides paraquat and atrazine.
  58. ncbi Multiple origins for black-grass (Alopecurus myosuroides Huds) target-site-based resistance to herbicides inhibiting acetyl-CoA carboxylase
    Christophe Délye
    Institut National de la Recherche Agronomique, UMR Biologie et Gestion des Adventices, BP 86510, 21065 Dijon, France
    Pest Manag Sci 60:35-41. 2004
    We have investigated the process of evolution of target-site-based resistance to herbicides inhibiting acetyl-CoA carboxylase (ACCase) in nine French populations of black-grass (Alopecurus myosuroides Huds)...
  59. ncbi European Union bans atrazine, while the United States negotiates continued use
    Jennifer Beth Sass
    Health and Environment Program, Natural Resources Defense Council, 1200 New York Avenue, N W, Suite 400, Washington, DC 20005, USA
    Int J Occup Environ Health 12:260-7. 2006
    ..Many of the details of these negotiations continue to be withheld from the public, despite EPA regulations and federal open-government laws that require such decisions to be made in the open...
  60. pmc A powerful molecular engineering tool provided efficient Chlamydomonas mutants as bio-sensing elements for herbicides detection
    Maya D Lambreva
    Institute of Crystallography, National Research Council, Monterotondo Scalo, Rome, Italy
    PLoS ONE 8:e61851. 2013
    ..about ecological damage and human health threats derived by persistent contamination of water and soil with herbicides, and emerging of bio-sensing technology as powerful, fast and efficient tool for the identification of such ..
  61. ncbi Natural products in crop protection
    Franck E Dayan
    Natural Products Utilization Research Unit, Agricultural Research Service, United States Department of Agriculture, University, MS 38677, USA
    Bioorg Med Chem 17:4022-34. 2009
    ..This review covers the historical use of natural products in agricultural practices, the impact of natural products on the development of new pesticides, and the future prospects for natural products-based pest management...
  62. ncbi The clinical features of acute kidney injury in patients with acute paraquat intoxication
    Su Ji Kim
    Department of Internal Medicine, Soonchunhyang University Cheonan Hospital, Cheonan, Korea
    Nephrol Dial Transplant 24:1226-32. 2009
    ..We hypothesized that acute kidney injury (AKI) in patients with acute PQ poisoning would provide a model for the clinical features of ROS-induced AKI...
  63. ncbi Fitness costs associated with evolved herbicide resistance alleles in plants
    Martin M Vila-Aiub
    Western Australian Herbicide Resistance Initiative WAHRI, School of Plant Biology, The University of Western Australia, Crawley, WA 6009, Australia
    New Phytol 184:751-67. 2009
    ..The findings of this review are discussed within the context of the plant defence trade-off theory and herbicide resistance evolution...
  64. ncbi The impact of the herbicide atrazine on growth and photosynthesis of seagrass, Zostera marina (L.), seedlings
    Yaping Gao
    Yellow Sea Fisheries Research Institute, Chinese Academy of Fisheries Science, Qingdao 266071, China
    Mar Pollut Bull 62:1628-31. 2011
    ..These results indicate that atrazine presents a potential threat to seagrass seedling functioning and that the impact is much higher than for adult plants...
  65. ncbi Developmental immunotoxicity of atrazine in rodents
    Alexander M Rowe
    Department of Microbiology, Immunology and Cell Biology, West Virginia University School of Medicine, Morgantown, WV 26506 9177, USA
    Basic Clin Pharmacol Toxicol 102:139-45. 2008
    ..These results demonstrate a sex- and age-dependant effect of prenatal exposure to atrazine on the immune system of the adult offspring using two rodent strains...
  66. ncbi Symbiont-specific responses in foraminifera to the herbicide diuron
    Joost W van Dam
    The University of Queensland, Centre for Marine Studies, St Lucia, QLD 4072, Australia
    Mar Pollut Bull 65:373-83. 2012
    ..The high diversity, widespread occurrence and relative sensitivity make foraminifera good bioindicator organisms to evaluate phytotoxic stress on coral reefs...
  67. ncbi Complex I is the major site of mitochondrial superoxide production by paraquat
    Helena M Cocheme
    Medical Research Council Dunn Human Nutrition Unit, Wellcome Trust MRC Building, Hills Road, Cambridge CB2 0XY, United Kingdom
    J Biol Chem 283:1786-98. 2008
    ..Together this membrane potential-dependent uptake across the mitochondrial inner membrane and the subsequent rapid reduction to the paraquat radical cation explain the toxicity of paraquat to mitochondria...
  68. ncbi Effect assessment of the herbicide paraquat on a green alga using differential gene expression and biochemical biomarkers
    An Jamers
    Laboratory for Ecophysiology, Biochemistry and Toxicology, Department of Biology, University of Antwerp, Groenenborgerlaan 171, 2020 Antwerp, Belgium
    Environ Toxicol Chem 29:893-901. 2010
    ....
  69. ncbi Pre- and postnatal toxicity of the commercial glyphosate formulation in Wistar rats
    Eliane Dallegrave
    Department of Pharmacology, Federal University of Rio Grande do Sul, Rua Sarmento Leite 500 sala 202, 90046 900, Porto Alegre, RS, Brazil
    Arch Toxicol 81:665-73. 2007
    ..These findings suggest that in utero and lactational exposure to glyphosate-Roundup may induce significant adverse effects on the reproductive system of male Wistar rats at puberty and during adulthood...
  70. ncbi Long term monitoring of photosystem II herbicides--correlation with remotely sensed freshwater extent to monitor changes in the quality of water entering the Great Barrier Reef, Australia
    Karen Kennedy
    The University of Queensland, The National Research Centre for Environmental Toxicology EnTOX, Coopers Plains, Brisbane, QLD 4108, Australia
    Mar Pollut Bull 65:292-305. 2012
    Photosystem II (PSII) herbicides are used in large quantities on agricultural lands adjoining the Great Barrier Reef (GBR)...
  71. ncbi Isolation and expression of genes for acetolactate synthase and acetyl-CoA carboxylase in Echinochloa phyllopogon, a polyploid weed species
    Satoshi Iwakami
    Kyoto University, Graduate School of Agriculture, Kitashirakawa Oiwake cho, Sakyo ku, Kyoto, Japan
    Pest Manag Sci 68:1098-106. 2012
    ..cause of herbicide resistance to acetolactate synthase (ALS)- and acetyl-CoA carboxylase (ACCase)-inhibiting herbicides in arable weeds, whereas non-target-site resistance is rarely reported...
  72. ncbi Inclusion complex of butachlor with beta-cyclodextrin: characterization, solubility, and speciation-dependent adsorption
    Haitao Bian
    Key Laboratory of Industrial Ecology and Environmental Engineering Ministry of Education, Department of Environmental Science and Technology, Dalian University of Technology, Dalian, People s Republic of China
    J Agric Food Chem 57:7453-8. 2009
    ..These results indicate that beta-CD may be used as a formation additive to improve the solubility of butachlor, reduce its adsorption on soil, and increase the availability of butachlor for weeds...
  73. ncbi Evolution over time of the agricultural pollution of waters in an area of Salamanca and Zamora (Spain)
    Rita Carabias-Martínez
    Departamento de Quimica Analitica, Nutricion y Bromatologia, Facultad de Quimica, Universidad de Salamanca, 37008 Salamanca, Spain
    Water Res 37:928-38. 2003
    A survey of the herbicides present in surface and groundwaters was conducted in 1999 in an area of the provinces of Salamanca and Zamora (Central-Western Spain) to assess the degree of pollution of the agricultural land and seasonal ..
  74. ncbi An isoleucine to leucine mutation in acetyl-CoA carboxylase confers herbicide resistance in wild oat
    Michael J Christoffers
    Department of Plant Sciences, 474A Loftsgard Hall, North Dakota State University, Fargo, ND 58105, USA
    Genome 45:1049-56. 2002
    Wild oat (Avena fatua L.) populations resistant to herbicides that inhibit acetyl-CoA carboxylase (ACCase; EC 6.4.1.2) represent an increasingly important weed control problem...
  75. ncbi Herbicides in ground water beneath Nebraska's Management Systems Evaluation Area
    Roy F Spalding
    Dep of Agronomy and Horticulture, Univ of Nebraska, Lincoln, NE 68583 0915, USA
    J Environ Qual 32:92-9. 2003
    ..Triazine and acetamide herbicides applied on the site and their transformation products had the highest frequencies of detection...
  76. ncbi Herbicide resistances in Amaranthus tuberculatus: a call for new options
    Patrick J Tranel
    Department of Crop Sciences, University of Illinois, 1201 West Gregory Drive, Urbana, Illinois 61801, USA
    J Agric Food Chem 59:5808-12. 2011
    ..Making this weed particularly problematic to manage is its demonstrated ability to evolve resistance to herbicides. Herbicides to which A...
  77. pmc Predictors of 2,4-dichlorophenoxyacetic acid exposure among herbicide applicators
    Parveen Bhatti
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20892 7238, USA
    J Expo Sci Environ Epidemiol 20:160-8. 2010
    ..As a large proportion of the variance remained unexplained, further studies should be conducted to try to systematically assess other exposure determinants...
  78. pmc Mechanism for the inhibition of the carboxyltransferase domain of acetyl-coenzyme A carboxylase by pinoxaden
    Linda P C Yu
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    Proc Natl Acad Sci U S A 107:22072-7. 2010
    ..The carboxyltransferase (CT) domain of this enzyme is the site of action for three different classes of herbicides, as represented by haloxyfop, tepraloxydim, and pinoxaden...
  79. ncbi Evaluation of side-effects of glyphosate mediated control of giant reed (Arundo donax) on the structure and function of a nearby Mediterranean river ecosystem
    Laura Puértolas
    Ecology Department, University of Barcelona, Av Diagonal, 645, 08028 Barcelona, Spain
    Environ Res 110:556-64. 2010
    ..These results emphasize the importance of combined chemical, ecological and specific biological responses to identify ecological effects of pesticides in the field...
  80. pmc Caffeine protects against combined paraquat and maneb-induced dopaminergic neuron degeneration
    Anil Kachroo
    MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA
    Exp Neurol 223:657-61. 2010
    ..Caffeine at 20mg/kg significantly reduced TH+ neuron loss (to 85% of the respective control). The results demonstrate the neuroprotective potential of caffeine in a chronic pesticide exposure model of model of PD...
  81. ncbi Comparative toxicity of bentazon and molinate on growth, photosynthetic pigments, photosynthesis, and respiration of the Portuguese ricefield cyanobacterium Nostoc muscorum
    Victor Galhano
    Department of Biology and Environmental Engineering Centre for Research and Technology of Agro Environment and Biological Sciences, University of Tras os Montes and Alto Douro, Apartado 1013 5001 801 Vila Real, Portugal
    Environ Toxicol 25:147-56. 2010
    Bentazon and molinate are selective herbicides recommended for integrated weed management in rice...
  82. pmc A different mechanism for the inhibition of the carboxyltransferase domain of acetyl-coenzyme A carboxylase by tepraloxydim
    Song Xiang
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    Proc Natl Acad Sci U S A 106:20723-7. 2009
    ..Haloxyfop and tepraloxydim belong to two distinct classes of commercial herbicides and kill sensitive plants by inhibiting the carboxyltransferase (CT) activity of ACC...
  83. ncbi Comparative cytotoxicity of alachlor, acetochlor, and metolachlor herbicides in isolated rat and cryopreserved human hepatocytes
    Vijay M Kale
    Department of Toxicology, University of Louisiana at Monroe, Monroe, LA 71209, USA
    J Biochem Mol Toxicol 22:41-50. 2008
    Noncancerous adverse effects observed at the lowest dose for chloroacetanilide herbicides alachlor [2-chloro-2',6'-diethyl-N-(methoxymethyl)-acetanilide] and acetochlor [2-chloro-2'-methyl-6'-ethyl-N-(ethoxymethyl)acetanilide], but not ..
  84. ncbi The epidemiology of glyphosate-surfactant herbicide poisoning in Taiwan, 1986-2007: a poison center study
    Ying Ju Chen
    Department of Emergency Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, ROC
    Clin Toxicol (Phila) 47:670-7. 2009
    ..However, there are many controversies with regard to the exact causes and determinants of developing severe/death outcome after exposure to GlySH...
  85. ncbi Validation of photosynthetic-fluorescence parameters as biomarkers for isoproturon toxic effect on alga Scenedesmus obliquus
    David Dewez
    University of Quebec in Montreal, Department of Chemistry, Environmental Toxicology Research Center TOXEN, 2101, Jeanne Mance, Montreal, Quebec H2X 2J6, Canada
    Environ Pollut 151:93-100. 2008
    ..Correlations between cells density and those photosynthetic-fluorescence parameters provide supporting evidence to use them as biomarkers of toxicity for environmental pollutants...
  86. ncbi Predicting acute complicated glyphosate intoxication in the emergency department
    Jeong Mi Moon
    Department of Emergency Medicine, Chonnam National University Hospital, Gwangju, Republic of Korea
    Clin Toxicol (Phila) 48:718-24. 2010
    ..Thus, we sought to identify independent factors that could predict which patient will develop subsequent medical complications...
  87. ncbi Comparative effects of the formulation of glyphosate-surfactant herbicides on hemodynamics in swine
    Hsin Ling Lee
    Graduate Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    Clin Toxicol (Phila) 47:651-8. 2009
    Most of the glyphosate-surfactant herbicides (GlySH) are formulated commercial products containing isopropylamine (IPA) salt of glyphosate (IPAG), variable amount of a surfactant, and water...
  88. ncbi Changes in sperm characteristics and induction of oxidative stress in the testis and epididymis of experimental rats by a herbicide, atrazine
    Sunny O Abarikwu
    Drug Metabolism Laboratory, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria
    Arch Environ Contam Toxicol 58:874-82. 2010
    ..The results suggest that atrazine impairs reproductive function and elicits a depletion of the antioxidant defense system in the testis and epididymis, indicating the induction of oxidative stress...
  89. pmc Gene amplification confers glyphosate resistance in Amaranthus palmeri
    Todd A Gaines
    Department of Bioagricultural Sciences and Pest Management, Colorado State University, Fort Collins, CO 80523, USA
    Proc Natl Acad Sci U S A 107:1029-34. 2010
    ..This occurrence of gene amplification as an herbicide resistance mechanism in a naturally occurring weed population is particularly significant because it could threaten the sustainable use of glyphosate-resistant crop technology...
  90. ncbi A bioaccumulation model for herbicides in Ulva rigida and Tapes philippinarum in Sacca di Goro lagoon (Northern Adriatic)
    Roberta Carafa
    European Commission, Joint Research Centre, Institute for Environment and Sustainability, Italy
    Chemosphere 74:1044-52. 2009
    A bioaccumulation model to predict concentrations of s-triazine herbicides in the macroalgae Ulva rigida and in clams Tapes philippinarum has been implemented, calibrated and validated...
  91. ncbi Cross-resistance patterns to ACCase-inhibiting herbicides conferred by mutant ACCase isoforms in Alopecurus myosuroides Huds. (black-grass), re-examined at the recommended herbicide field rate
    Christophe Délye
    INRA, UMR 1210 Biologie et Gestion des Adventices, F 21000 Dijon, France
    Pest Manag Sci 64:1179-86. 2008
    ..The authors aimed to connect the presence of mutant ACCase isoform(s) in A. myosuroides with resistance to five ACCase inhibitors (fenoxaprop, clodinafop, haloxyfop, cycloxydim, clethodim) sprayed at the recommended field rate...
  92. ncbi Glyphosate-resistant crops: history, status and future
    Gerald M Dill
    Monsanto, 800 N Lindbergh Blvd, St Louis, MO 63167, USA
    Pest Manag Sci 61:219-24. 2005
    ..However, global public acceptance of biotechnology-derived products will continue to impact the rate of adoption of this and other new innovations derived from transformation technology...
  93. ncbi Rhabdomyolysis from an intramuscular injection of glyphosate-surfactant herbicide
    Sheng Fu Weng
    Department of Emergency, Taichung Veterans General Hospital, Taichung, Taiwan, Republic of China
    Clin Toxicol (Phila) 46:890-1. 2008
    ..Most intoxicated cases are from ingestion, inhalation, and skin exposure. Intramuscular injection of GlySH has never been reported. We present a case of GlySH intoxication via intramuscular injection...
  94. ncbi Oxidative stress induced by loss of Cu,Zn-superoxide dismutase (SOD1) or superoxide-generating herbicides causes axonal degeneration in mouse DRG cultures
    Lindsey R Fischer
    Department of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Acta Neuropathol 119:249-59. 2010
    ..To test susceptibility to increased superoxide production, we exposed wild-type DRGs to the redox-cycling herbicides paraquat and diquat (DQ)...
  95. ncbi A comparative study of rac- and S-metolachlor toxicity to Daphnia magna
    Huijun Liu
    Institute of Environmental Science, Department of Environmental Science, Zhejiang University, P O Box 3041, Hangzhou, Zhejiang Province 310029, China
    Ecotoxicol Environ Saf 63:451-5. 2006
    ..01 mgL(-1) but not reduced only when S-metolachlor concentration was higher than 0.5 mgL(-1). The results of chronic toxicity indicated that rac-metolachlor was significantly (P<0.05) more toxic than S-metolachlor to D. magna...
  96. pmc Cellular toxicity of surfactants used as herbicide additives
    Ho Yeon Song
    Department of Immunology, College of Medicine, Soonchunhyang University, Cheonan, Korea
    J Korean Med Sci 27:3-9. 2012
    ..In conclusion, our results suggest that the toxicity of surfactants be taken care of pertinent treatment of acute herbicide intoxication...
  97. ncbi Effects of sub-chronic exposure to terbutryn in common carp (Cyprinus carpio L.)
    J Velisek
    University of South Bohemia Ceske Budejovice, Faculty of Fisheries and Protection of Waters, Research Institute of Fish Culture and Hydrobiology, Vodnany, Czech Republic
    Ecotoxicol Environ Saf 73:384-90. 2010
    ..Cell shape changes and lipid inclusions were found in hepatocytes, and there was destruction of caudal kidney tubules when compared to control fish...
  98. ncbi Effect of pulse herbicidal exposure on scenedesmus vacuolatus: a comparison of two photosystem II inhibitors
    Nathalie Vallotton
    Eawag, Swiss Federal Institute of Aquatic Science and Technology, Duebendorf, Switzerland
    Environ Toxicol Chem 27:1399-407. 2008
    ..We further explored whether the time-dependent toxicity is similar for herbicides inhibiting the photosystem II (PSII)...
  99. ncbi Paraquat neurotoxicity is distinct from that of MPTP and rotenone
    Jason R Richardson
    Center for Neurodegenerative Disease, School of Medicine and Department of Environmental and Occupational Health, Rollins School of Public Health, Emory University, Atlanta, Georgia 30322, USA
    Toxicol Sci 88:193-201. 2005
    ..These data indicate that, despite the apparent structural similarity to MPP+, paraquat exerts its deleterious effects on dopamine neurons in a manner that is unique from rotenone and MPTP...
  100. ncbi Novel cell wall architecture of isoxaben-habituated Arabidopsis suspension-cultured cells: global transcript profiling and cellular analysis
    Iain W Manfield
    Centre for Plant Sciences, University of Leeds, Leeds LS2 9JT, UK
    Plant J 40:260-75. 2004
    ..In silico analysis of differentially expressed genes with unknown functions identified a putative glycosyltransferase and collagen-like putative cell wall protein...
  101. ncbi Effects of acute exposure to metribuzin on some hematological, biochemical and histopathological parameters of common carp (Cyprinus carpio L.)
    J Velisek
    Research Institute of Fish Culture and Hydrobiology Vodnany, University of South Bohemia Ceske Budejovice, Zatisi 728 II, 389 25 Vodnany, Czech Republic
    Bull Environ Contam Toxicol 82:492-5. 2009
    ..Histopathological examination revealed hyaline degeneration of the epithelial cells of renal tubules of the caudal kidney. This alteration of kidney resulted in hypoproteinemia, followed by generation of transudate in body cavity...

Research Grants62

  1. Naturally Occurring Agent for Alcohol Liver Diseases
    YUE WEI LEE; Fiscal Year: 2003
    ..1) conduct field inspection of the collection, processing, extraction, and contamination control (insecticides, herbicides, and chemical fertilizers) of the seed of Milk Thistle; (2) optimize the analytical HPLC conditions for ..
  2. Pyruvate Dehydrogenase kinase as Therapeutic Target for Hepatic Steatosis, Obesit
    Robert A Harris; Fiscal Year: 2012
    ..Furthermore, veterans exposed to dioxin- contaminated herbicides in Vietnam are particularly prone to the development of type 2 diabetes and therefore hepatic steatosis, NASH, ..
  3. Oxidative stress and neurogenetic networks in Drosophila
    Robert R H Anholt; Fiscal Year: 2010
    ..in environmental health science is to assess the effects of environmental chemicals such as pesticides or herbicides on genetic risk for neurodegenerative diseases as manifest through locomotor dysfunction (e.g...
  4. Paternal Environmental Exposures and Reproductive Outcomes: A Comparison of in Vi
    DEBORAH ANN HANSEN; Fiscal Year: 2013
    ..abnormalities have been reported in F1 and F2 generations following paternal exposures to pesticides, herbicides, and radiation...
  5. Alpha-Synuclein-Metal Complexes and Oxidative Stress in Parkinson's Disease
    Feimeng Zhou; Fiscal Year: 2012
    ..g., antioxidants such as flavonoids or PD risk factors such as herbicides) will also be conducted. A variety of analytical techniques (e.g...
  6. HYDROLYTIC ENZYMES IN THE METABOLISM OF TOXINS
    Bruce D Hammock; Fiscal Year: 2013
    ..Along with 15% of the world's pharmaceuticals, common herbicides and personal care products are also known to act on the arachidonate cascade...
  7. Precocious immune senescence induced by pre- & postnatal atrazine exposure
    John B Barnett; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE 1Atrazine is one of the most heavily used herbicides in the United States of America (USA) with approximately 80 million pounds applied to crops during a growing ..
  8. Air pollution and Parkinson disease: a GIS-based approach
    Natalia Palacios; Fiscal Year: 2013
    ..substantially to risk of disease and PD risk has been shown to be increased among persons exposed to pesticides, herbicides and agricultural chemicals, and decreased among tobacco smokers...
  9. Molecular Epidemiology of NHL and CLL
    James R Cerhan; Fiscal Year: 2012
    ..and farming/pesticide exposure (including farm practices and exposure to phenoxyacetic acid and triazine herbicides and organophosphate insecticides);3) To evaluate gene-environment interactions in the etiology of NHL, with a ..
  10. Role of Oxidative Stress and Protein Transporters in Glyphosate and Mancozeb Neur
    Vanessa A Fitsanakis; Fiscal Year: 2012
    ..work will provide evidence related to mechanisms involved in intracellular transport of glyphosate-containing herbicides (i.e., TD, RoundUP), or manganese-containing fungicides (i.e., MZ, maneb)...
  11. Chemically-Rich Structure and Dynamics in the Active Site of Tryptophan Synthase
    Leonard J Mueller; Fiscal Year: 2013
    ..animals and in humans makes the tryptophan synthase nanomachine a potential target both for the development of herbicides, and for the design of drugs to treat infectious disease...
  12. MOLECULAR BASIS OF SELECTIVE P450 2B FUNCTION
    James R Halpert; Fiscal Year: 2013
    ..health because it is induced by pesticides and polychlorinated biphenyls (PCBs) and metabolizes insecticides, herbicides, industrial chemicals, solvents, and PCBs...
  13. A Microfluidic Biochip for Rapid Screening of Pesticide Residue
    Xiaoli Su; Fiscal Year: 2010
    ..Many pesticides, particularly herbicides, can inhibit photosynthesis in a concentration-dependent manner...
  14. The Enzymology of Phosphonate Metabolism
    Frank M Raushel; Fiscal Year: 2013
    ..significant importance to human health since these compounds constitute a rapidly growing class of antibiotics, herbicides, nerve agents and antiviral drugs...
  15. Risk Factors and Potential Protective Medications for Parkinson Disease
    DAVID W SPARROW; Fiscal Year: 2012
    ..whether the risk of Parkinson's disease (PD) among veterans of the Vietnam War is predicted by exposure to herbicides, lower cholesterol, diabetes, higher body mass index (BMI), and use of statins (3-hydroxy-3-methylglutaryl-..
  16. Susceptibility of Primate Dopamine Neurons to Toxicity During Development
    John D Elsworth; Fiscal Year: 2012
    ..MPTP is structurally related to herbicides that have been implicated in Parkinson's disease...
  17. Mitochondrial mechanisms of redox cycling agents
    Manisha N Patel; Fiscal Year: 2013
    ..The extensive use of these agents as a landscape and aquatic herbicides underscores the importance of their environmental and occupational risk...
  18. Pesticide-mediated inhibition of UBA1 and cumulative risk for Parkinson's Disease
    William M Valentine; Fiscal Year: 2013
    ..presented in this application are guided by the following working Hypothesis: The triazine and thiocarbamate herbicides, and the diaklydithiocarbamate and benomyl based fungicides covalently modify and inhibit UBA1 activating enzyme ..
  19. Biocatalytic Use of Cytochrome P450 Enzymes
    SHEEL DODANI; Fiscal Year: 2013
    ..g. explosives, herbicides, fluorophores), pharmaceuticals, and biomolecules bearing the nitro functional group...
  20. Food Safety and Security Monitoring Project (U18), FERN Chemical Laboratories
    Shane A Wyatt; Fiscal Year: 2013
    ..by expanding LC/MS toxin screens to compounds that partition into the water phase, such as the contact herbicides diquat and paraquat...
  21. Echinacea: Standardized Product & Supply Provision
    Xiping Wang; Fiscal Year: 2004
    ..germination; 4) soil condition and materials used for quality raw material; 5) alternatives to pesticides/herbicides for organic farming that is not time consuming nor expensive; 6) Echinacea product that is manufactured in the ..
  22. Ecological and Health Consequences of the Vietnam War
    Linda Schwartz; Fiscal Year: 2001
    ..A major focus of the discussion will be the human health and environmental consequences of the use of herbicides, especially 2,4-dichlorophenoxyacetic acid (2,4-D), 2,4,5-trichlorophenoxyacetic acid (2,4,5-T), and inevitably, ..
  23. HYDROLYTIC ENZYMES IN THE METABOLISM OF TOXINS
    Bruce Hammock; Fiscal Year: 2007
    ..in objective 1 advances understanding enzyme catalysis and inhibition by several compounds including commercial herbicides and insecticides...
  24. DEPOSITION OF VOLATILE AEROSOLS IN THE RESPIRATORY TRACT
    Sidney Soderholm; Fiscal Year: 1991
    ..Some examples of volatile aerosols include industrial chemicals (hydroquinone, glycerol, TNT), pesticides and herbicides (atrazine, ethion, carbofuran, and disulfoton), and "tear gas"...
  25. FUNGAL POLYKETIDE SYNTHASES
    CHARLES SIH; Fiscal Year: 2001
    ..in the design of novel protein catalysts that can make biotechnologically valuable compounds, including herbicides, insecticides, antiparasiticides, pharmaceuticals and biodegradable polymers, for many industrial uses...
  26. CHEMICAL EFFECTS ON METABOLISM AND REPRODUCTION
    Mary Haasch; Fiscal Year: 2001
    ..PPAs are a structurally-diverse group of chemicals including herbicides, solvents, and plasticizers, that are known fatty acid, retinoid and endocrine disrupters...
  27. GPS Weeding
    Fadi A Fathallah; Fiscal Year: 2010
    ..Weeds are currently controlled by chemical herbicides and manual weeding, which is a strenuous task that exposes agricultural workers to various MSD and LBD risk ..
  28. HEMATOLYMPHOPOIETIC MALIGNANCIES IN ITALY
    Paolo Vineis; Fiscal Year: 1993
    ..Exposure to herbicides of the phenoxyacid variety (2,4,5-T; 2,4-D) has been reported to be associated with an increased risk of non-..
  29. MECHANISM BASED DRUG SELECTION AND DESIGN FOR T GONDII
    Keith Joiner; Fiscal Year: 1999
    ..iii) novel strategies for intervention, of which the most promising are cyclosporin analogs and dinitroaniline herbicides. The major goal of this application for renewal is to extend the substantial progress we have made in these ..
  30. Effects of Dioxin on Vietnamese Civilians
    David Carpenter; Fiscal Year: 2004
    ..the most highly exposed population to dioxin, secondary to the widespread spraying of Agent Orange and other herbicides during the Vietnam War...
  31. Design of New Enzyme Catalysts
    Kendall N Houk; Fiscal Year: 2012
    ..The initial target reactions will be of use in the synthesis of pharmaceutical targets and for the decomposition of a broad class of compounds utilized as pesticides and herbicides.
  32. A Data Resource for the Health and Environmental Consequences of the Vietnam War
    JEANNE STELLMAN; Fiscal Year: 2009
    ..Nearly 20 million gallons of herbicides were sprayed in Vietnam and Laos between 1961 and 1971, including more than 12 million gallons of dioxin-..
  33. GENETIC ANALYSIS OF MG-TETRAPYRROLE BIOSYNTHESIS
    Carl Bauer; Fiscal Year: 2005
    ..of the tetrapyrrole biosynthetic pathway has some far ranging practical implications, such as the design of herbicides that target enzymes in the Mg tetrapyrrole pathway, and the health implications of overproducing tetrapyrrole ..
  34. OXIDANT MECHANISMS IN DRUG-INDUCED HEPATIC NECROSIS
    Charles Smith; Fiscal Year: 2006
    ..Therapeutic uses of acetaminophen and furosemide are extensive, and diquat and paraquat are widely used herbicides. Although most recognized human toxicities arise from acute exposures or overdoses, often intentional, emerging ..
  35. Environmental Risk Factors and Canine Malignant Lymphoma
    Elizabeth Bertone Johnson; Fiscal Year: 2005
    ..studies in humans have suggested that exposure to household environmental tobacco smoke (ETS), lawn care herbicides, and pesticides such as those contained in flea control products may plausibly increase risk of NHL, but these ..
  36. BIOACTIVE AGENTS FROM DRYLAND BIODIVERSITY OF LATIN AMER
    Barbara Timmermann; Fiscal Year: 2004
    ..This ICBG project also searches for leads for agricultural crop protection (herbicides, fungicides and insecticides) and veterinary medicine...
  37. CHARACTERIZATION AND EXPRESSION OF TUBULIN GENES
    CAROLYN SILFLOW; Fiscal Year: 1991
    ..The isolation of mutants resistant to anti-microtubule herbicides has identified both tubulin and non- tubulin genes that may be important for microtubule organization and ..
  38. Reproductive Outcomes due to Past Exposure to Dioxins
    Irina Dardynskaia; Fiscal Year: 2005
    ..The Ufa cohort consists of approximately 500 individuals employed in the production of chlorphenoxy herbicides at this plant between 1961 and 1987...
  39. NEW MODELS FOR COMPARATIVE STUDIES OF GONADAL TUMORS
    REBECCA VAN BENEDEN; Fiscal Year: 2006
    ..Tumor incidence has been correlated with the use of the herbicides 2,4 dichlorophenoxyacetic acid (2,4-D) and dioxin-contaminated 2,4,5-trichiorophenoxyactic acid (2,4,5-T)...
  40. Non-Antibiotic Selectable Markers for Bacillus Anthracis
    James Kirby; Fiscal Year: 2009
    ..will define the ability of markers conferring resistance to bacteriocins, heavy metals, chemotherapeutics, and herbicides to function as selectable markers in Bacillus anthracis...
  41. COMPARATIVE MECHANISTIC STUDIES OF ISOFUNCTIONAL ENZYMES
    RONALD VIOLA; Fiscal Year: 1993
    ..with the aim of identifying lead compounds that can serve as models for the synthesis of potential drugs or herbicides against target enzymes in this pathway...
  42. PEROXISOME PROLIFERATOR-DEPENDENT GENE REGULATION
    JOHN VANDEN HEUVEL; Fiscal Year: 1999
    ..Peroxisome proliferators include certain hypolipidemic drugs, phthalate ester plasticizers and various herbicides and pesticides...
  43. Pesticide Dose Monitoring in Turf Applicators
    Shelley Harris; Fiscal Year: 2004
    ..on spraying practices, hygiene practices, and other variables which may affect their daily exposure to herbicides. Current pesticide use reported by the applicators will be compared with actual use data obtained from employer ..
  44. MICROBIAL DEGRADATION OF AGENT ORANGE
    Ananda Chakrabarty; Fiscal Year: 2004
    Various chemicals are released in our environment as herbicides/pesticides, degreasers, fire retardants, industrial solvents o as by-products of chemical industry, leading to major environmental pollution problem. The U.S...
  45. THE GENETIC TOXICOLOGY OF TWO S-TRIAZINE HERBICIDES
    PETER MC GUIRE; Fiscal Year: 1980
    The proposed investigation is designed to gain insight into the mechanism by which two s-triazine herbicides are metabolized to derivatives which are mutagenic in prokaryote and mammalian cell test systems...
  46. EPIDEMIOLOGY OF PARKINSONS DISEASE AND FARM RISK FACTORS
    Daniel Strickland; Fiscal Year: 1999
    ..Specific factors to be investigated are: 1) farm and non-farm exposure to pesticides (including herbicides, insecticides, fungicides, and rodenticides); 2) occupational exposures (farm and non-farm) to other agents, ..
  47. Dinitroaniline Herbicide Resistance in Toxoplasma gondii
    MARIA FICHERA; Fiscal Year: 2001
    ..gondii. Dinitroaniline herbicides have been shown to kill Toxoplasma as well as other related parasites, without harming mammalian cells...
  48. Miscarriage and Birth Defects in 20th-Century America
    LESLIE REAGAN; Fiscal Year: 2005
    ..causes of miscarriage and birth defects were identified (namely syphilis, thalidomide, rubella, and herbicides) and became part of the public, political discourses as well as the subject of scientific research...
  49. DINITROANILINE HERBICIDE METABOLISM & TOXICOLOGY
    JUDD NELSON; Fiscal Year: 1980
    A primary objective of this study will be to identify and quantify metabolites of selected dinitroaniline herbicides from rats in both in vivo and liver microsomal in vitro metabolism studied...
  50. NEW MODELS FOR COMPARATIVE STUDIES OF GONADAL TUMORS
    REBECCA VAN BENEDEN; Fiscal Year: 1999
    ..Tumor incidence is correlated with the use of the phenoxyaretic arid herbicides 2,4-D and 2,4,5-T...
  51. CHORISMATE MUTASE--MECHANISM OF A NOVEL ENZYMIC REACTION
    Eileen Jaffe; Fiscal Year: 1991
    ..in humans, an understanding of its mechanism can lead to the development of new antibiotics, bacteriostatics, or herbicides. The long term objective is to use the knowledge of the CMPDH reaction mechanism to aid in design of new ..
  52. CHIRAL SYNTHON: 1,2-OXAPHOSPHETANE 2-OXIDES
    ERIC DOLENCE; Fiscal Year: 2001
    ..include transition state analogue inhibitors of proteases, haptens for antibody production, pesticides, herbicides, fungicides and growth control regulators...
  53. CYTOSKELETAL INJURY & MECHANISM OF HERBICIDE TOXICITY
    Iih Nan Chou; Fiscal Year: 1991
    The overall goal of the proposed research is to elucidate the mechanisms of toxic action of phenoxy acid herbicides at subcellular and molecular levels...
  54. TETRAHYDROISOQUINOLINES AND PARKINSON'S DISEASE
    Mark leDoux; Fiscal Year: 2006
    ..risk factors for Parkinson's disease include well water use, rural living, and exposure to pesticides and herbicides. The insecticide rotenone can inhibit complex I of the respiratory chain and cause Parkinsonism in rats...
  55. TOWARD A PREDICTIVE TOXICOLOGY
    CYNTHIA SELASSIE; Fiscal Year: 2000
    ..The preponderance of drugs, pesticides, herbicides and environmental chemicals that contain the phenolic moiety makes it an insidious and potent threat to our ..
  56. THE APICOPLAST: A NEW TARGET FOR ANTI-MALARIAL DRUGS
    James Bigelow; Fiscal Year: 2001
    ..We will evaluate 3 classes of such herbicides for in vitro anti-malarial activity, demonstrate novelty of action, test for activity in resistant malarial ..
  57. MECHANISMS OF MOTILITY AND CHEMOTAXIS IN BACTERIA
    Melvin Simon; Fiscal Year: 2006
    ..Thus, the histidine kinase represents an excellent target for the development of therapeutic agents, e.g. antibiotics, fungicides and herbicides. We will continue to explore this possibility.
  58. PROPANIL EFFECT ON IMMUNITY TO INFECTION IN THE LIVER
    Rosana Schafer; Fiscal Year: 2000
    Propanil (3,4-dichloropropionanilide) is one of the most extensively used and economically important acylanilide herbicides in the United States. As such, humans are occupationally exposed to propanil...
  59. MECHANISM OF NEPHROTOXICITY OF ENVIRONMENTAL HALOCARBONS
    RICK SCHNELLMANN; Fiscal Year: 1991
    ..Because HHs are used widely as drugs, pesticides and herbicides, humans and animals are constantly exposed to these environmental pollutants...
  60. ENDOCRINE DISRUPTORS IN THE DEVELOPING NERVOUS SYSTEM
    Leslie Henderson; Fiscal Year: 2000
    ..both the evidence and the concern have been steadily growing that synthetic compounds, including pesticides, herbicides, and industrial solvents, have deleterious effects on the development of a wide range of species by disrupting ..
  61. TOXICOLOGY OF POLYCHLORINATED AZOXY AND AZOBENZENES
    MONG TSENG HSIA; Fiscal Year: 1980
    ..environmental toxicants resulting from industrial manufacturing and agricultural application of chloroanilide herbicides. In vitro short-term studies conducted in our laboratory have indicated the carcinogenic potential of 3,3',4,4'-..
  62. DRUG DISCOVERY FOR TREATMENT OF OBESITY
    Ilya Okun; Fiscal Year: 2004
    ..with compound libraries containing a large number of compounds related in structure to the known ACC-specific herbicides. Lead candidates, identified by inhibition of growth of yeast replacement strains, will be evaluated ..