luminescent agents

Summary

Summary: Compound such as LUMINESCENT PROTEINS that cause or emit light (PHYSICAL LUMINESCENCE).

Top Publications

  1. ncbi Applications of luminescent inorganic and organometallic transition metal complexes as biomolecular and cellular probes
    Kenneth Kam Wing Lo
    Department of Biology and Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong, P R China
    Dalton Trans 41:6021-47. 2012
  2. ncbi Bright monomeric red fluorescent protein with an extended fluorescence lifetime
    Ekaterina M Merzlyak
    Evrogen JSC, Miklukho Maklaya 16 10, Moscow 117997, Russia
    Nat Methods 4:555-7. 2007
  3. ncbi Design and synthesis of iridium(III) azacrown complex: application as a highly sensitive metal cation phosphorescence sensor
    Mei Lin Ho
    Department of Chemistry, National Taiwan University, Taipei, 106, Taiwan
    Org Biomol Chem 4:98-103. 2006
  4. ncbi Phosphorescence imaging of living cells with amino acid-functionalized tris(2-phenylpyridine)iridium(III) complexes
    Peter Steunenberg
    Supramolecular Chemistry and Technology, MESA Institute for Nanotechnology, University of Twente, P O Box 217, 7500 AE, Enschede, The Netherlands
    Inorg Chem 51:2105-14. 2012
  5. ncbi Label-free luminescent oligonucleotide-based probes
    Dik Lung Ma
    Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China
    Chem Soc Rev 42:3427-40. 2013
  6. ncbi Ratiometric phosphorescence imaging of Hg(II) in living cells based on a neutral iridium(III) complex
    Yongquan Wu
    Department of Chemistry, Fudan University, Shanghai, 200433, PR China
    Inorg Chem 50:7412-20. 2011
  7. ncbi Use of bioluminescent imaging to investigate the role of nuclear factor-kappaBeta in experimental non-small cell lung cancer metastasis
    Georgios T Stathopoulos
    Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
    Clin Exp Metastasis 25:43-51. 2008
  8. ncbi Structure and spectroscopy of oxyluciferin, the light emitter of the firefly bioluminescence
    Pance Naumov
    Department of Material and Life Science, and Frontier Research Base for Global Young Researchers, Graduate School of Engineering, Osaka University, 2 1 Yamada oka, Suita, Osaka, Japan
    J Am Chem Soc 131:11590-605. 2009
  9. ncbi Red-emitting luciferases for bioluminescence reporter and imaging applications
    Bruce R Branchini
    Department of Chemistry, Connecticut College, New London, CT 06320, USA
    Anal Biochem 396:290-7. 2010
  10. ncbi Structure, photophysical and electrochemical properties, biomolecular interactions, and intracellular uptake of luminescent cyclometalated iridium(III) dipyridoquinoxaline complexes
    Kenneth Yin Zhang
    Department of Biology and Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong, PR China
    Inorg Chem 49:2530-40. 2010

Detail Information

Publications222 found, 100 shown here

  1. ncbi Applications of luminescent inorganic and organometallic transition metal complexes as biomolecular and cellular probes
    Kenneth Kam Wing Lo
    Department of Biology and Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong, P R China
    Dalton Trans 41:6021-47. 2012
    ..Emphasis is put on the structural features, photophysical behavior, biomolecular interactions, cellular uptake, and intracellular localization properties of luminescent transition metal complexes...
  2. ncbi Bright monomeric red fluorescent protein with an extended fluorescence lifetime
    Ekaterina M Merzlyak
    Evrogen JSC, Miklukho Maklaya 16 10, Moscow 117997, Russia
    Nat Methods 4:555-7. 2007
    ..These properties make TagRFP an excellent tag for protein localization studies and fluorescence resonance energy transfer (FRET) applications...
  3. ncbi Design and synthesis of iridium(III) azacrown complex: application as a highly sensitive metal cation phosphorescence sensor
    Mei Lin Ho
    Department of Chemistry, National Taiwan University, Taipei, 106, Taiwan
    Org Biomol Chem 4:98-103. 2006
    ..Remarkable differentiation in spectral properties upon metal cation (e.g. Ca2+) complexation makes complex a highly sensitive phosphorescence probe...
  4. ncbi Phosphorescence imaging of living cells with amino acid-functionalized tris(2-phenylpyridine)iridium(III) complexes
    Peter Steunenberg
    Supramolecular Chemistry and Technology, MESA Institute for Nanotechnology, University of Twente, P O Box 217, 7500 AE, Enschede, The Netherlands
    Inorg Chem 51:2105-14. 2012
    ....
  5. ncbi Label-free luminescent oligonucleotide-based probes
    Dik Lung Ma
    Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China
    Chem Soc Rev 42:3427-40. 2013
    ..Based on the numerous examples of label-free luminescent DNA-based probes reported recently, we envisage that this field would continue to thrive and mature in the years to come...
  6. ncbi Ratiometric phosphorescence imaging of Hg(II) in living cells based on a neutral iridium(III) complex
    Yongquan Wu
    Department of Chemistry, Fudan University, Shanghai, 200433, PR China
    Inorg Chem 50:7412-20. 2011
    ..Importantly, cell imaging experiments have shown that [Ir(bt)(2)(acac)] is membrane permeable and can be used to monitor the changes in Hg(II) levels within cells in a ratiometric phosphorescence mode...
  7. ncbi Use of bioluminescent imaging to investigate the role of nuclear factor-kappaBeta in experimental non-small cell lung cancer metastasis
    Georgios T Stathopoulos
    Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
    Clin Exp Metastasis 25:43-51. 2008
    ..In conclusion, using bioluminescent detection of NF-kappaB activation in mouse lug adenocarcinoma cells, we found a negative impact of p65/RelA on NSCLC metastasis...
  8. ncbi Structure and spectroscopy of oxyluciferin, the light emitter of the firefly bioluminescence
    Pance Naumov
    Department of Material and Life Science, and Frontier Research Base for Global Young Researchers, Graduate School of Engineering, Osaka University, 2 1 Yamada oka, Suita, Osaka, Japan
    J Am Chem Soc 131:11590-605. 2009
    ..This conclusion is supported by the bioluminescence/fluorescence spectra and the NMR data, as well the crystal structures of OxyLH(2) and MOxyLH(2), where the conjugated acid (phenol) of the emitter exists as pure enol tautomer...
  9. ncbi Red-emitting luciferases for bioluminescence reporter and imaging applications
    Bruce R Branchini
    Department of Chemistry, Connecticut College, New London, CT 06320, USA
    Anal Biochem 396:290-7. 2010
    ..These results suggest that the novel enzymes should provide superior performance in dual-color reporter and in vivo imaging applications, and they illustrate the importance of codon optimization for assays in mammalian cells...
  10. ncbi Structure, photophysical and electrochemical properties, biomolecular interactions, and intracellular uptake of luminescent cyclometalated iridium(III) dipyridoquinoxaline complexes
    Kenneth Yin Zhang
    Department of Biology and Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong, PR China
    Inorg Chem 49:2530-40. 2010
    ..The results revealed that the complexes bound to the hydrophobic pockets of proteins, intercalated into the base-pairs of double-stranded DNA, but did not appear to interact with RNA...
  11. ncbi Developing red-emissive ruthenium(II) complex-based luminescent probes for cellular imaging
    Run Zhang
    State Key Laboratory of Fine Chemicals, School of Chemistry, Dalian University of Technology, Dalian 116024, PR China
    Bioconjug Chem 23:725-33. 2012
    ..The results suggest that the new probe could be a very useful tool for luminescence imaging analysis of the toxic thiophenol in intact cells...
  12. pmc Leishmania (Viannia) panamensis: an in vitro assay using the expression of GFP for screening of antileishmanial drug
    Rubén E Varela M
    Programa de Estudio y Control de Enfermedades Tropicales PECET, Universidad de Antioquia, Calle 62 No 52 59, Lab 632, Medellin, Colombia
    Exp Parasitol 122:134-9. 2009
    ..The availability of this fluorescent assay for infection of macrophages by L. (V.) panamensis facilitates drug discovery program for the Viannia species, which differ significantly from those of the Leishmania subgenus...
  13. doi A highly selective luminescent switch-on probe for histidine/histidine-rich proteins and its application in protein staining
    Dik Lung Ma
    Department of Applied Biology and Chemical Technology, Central Laboratory of the Institute of Molecular Technology for Drug Discovery and Synthesis, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China
    Angew Chem Int Ed Engl 47:3735-9. 2008
  14. ncbi Bioluminescence monitoring of intracranial glioblastoma xenograft: response to primary and salvage temozolomide therapy
    Eduard B Dinca
    Neuroscience Graduate Program, Mayo Clinic, Rochester, Minnesota, USA
    J Neurosurg 107:610-6. 2007
    ..In the current study we have applied BLI to the analysis of clinically relevant issues involving use of the DNA methylating agent temozolomide (TMZ) in a mouse model...
  15. ncbi Optical imaging of in vivo gene expression: a critical assessment of the methodology and associated technologies
    M Golzio
    IPBS CNRS UMR 5089, Toulouse, France
    Gene Ther 11:S85-91. 2004
    ..The present paper describes the physical and technological methodologies and associated problems of in vivo optical imaging. Several examples of in vivo detection of gene delivery are described...
  16. pmc Live cell imaging of repetitive DNA sequences via GFP-tagged polydactyl zinc finger proteins
    Beatrice I Lindhout
    Institute of Biology Leiden, Department of Molecular and Developmental Genetics, Clusius Laboratory, Leiden University, Wassenaarseweg 64, 2333 AL, Leiden, The Netherlands
    Nucleic Acids Res 35:e107. 2007
    ..Our data demonstrate that live cell imaging of specific DNA sequences can be achieved with artificial zinc finger proteins in different organisms...
  17. ncbi New approaches to in-cell detection of protein activity: genetically encoded chemiluminescence probes pave the way to robust HTS assays
    Louis Hodgson
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine of Yeshiva University, 1300 Morris ParkAvenue, Price Center 217, Bronx, New York 10461, USA
    ACS Chem Biol 3:335-7. 2008
    ..The biosensor design strategies are highly generalizable and will be extremely valuable for expanding the repertoire of screenable targets in living cell systems...
  18. ncbi Systemically transferred hematopoietic stem cells home to the subretinal space and express RPE-65 in a mouse model of retinal pigment epithelium damage
    Pelin Atmaca-Sonmez
    Department of Ophthalmology and Visual Sciences, University of Louisville, 301 E Muhammad Ali Blvd, Louisville, KY 40202, USA
    Exp Eye Res 83:1295-302. 2006
    ..Furthermore, the RPE-specific marker RPE-65 was expressed on adoptively transferred HSC in the denuded areas...
  19. ncbi Subcellular imaging of cancer cells in live mice
    Robert M Hoffman
    AntiCancer, Inc, San Diego, USA
    Methods Mol Biol 411:121-9. 2007
    ..Dual-color in vivo cellular imaging was also used to visualize trafficking, nuclear-cytoplasmic dynamics, and the viability of cancer cells after their injection into the portal vein of mice...
  20. pmc Potentiation of insulin-stimulated glucose transport by the AMP-activated protein kinase
    Jeong Sun Ju
    Department of Biology, Saint Louis University, 3507 Laclede Avenue, St Louis, MO 63103, USA
    Am J Physiol Cell Physiol 292:C564-72. 2007
    ....
  21. ncbi Effects of alginate inclusion on the vector properties of chitosan-based nanoparticles
    Kimberly L Douglas
    Department of Biomedical Engineering, McGill University, 3775 University St, Montreal, QC, Canada H3A 2B4
    J Control Release 115:354-61. 2006
    ..Overall, alginate inclusion improved the vector properties of chitosan-based nanoparticles, demonstrating superior transfection ability while maintaining biocompatibility and low toxicity...
  22. ncbi Sustained transgene expression in intervertebral disc cells in vivo mediated by microbubble-enhanced ultrasound gene therapy
    Kotaro Nishida
    Department of Orthopedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan
    Spine (Phila Pa 1976) 31:1415-9. 2006
    ..In vivo studies using a rat model were performed to determine the feasibility of microbubble-enhanced ultrasound gene transfer technique to the intervertebral disc...
  23. ncbi In vivo oxygen imaging using green fluorescent protein
    Eiji Takahashi
    Department of Physiology, Yamagata University School of Medicine, Yamagata, Japan
    Am J Physiol Cell Physiol 291:C781-7. 2006
    ..We conclude that the present technique using GFP as an oxygen indicator may allow in vivo molecular imaging of oxygen in organs...
  24. ncbi Aequorin luminescence-based assay for 5-hydroxytryptamine (serotonin) type 3 receptor characterization
    Jutta Walstab
    Institute of Pharmacology and Toxicology, University of Bonn, 53113 Bonn, Germany
    Anal Biochem 368:185-92. 2007
    ..In conclusion, the aequorin assay described here provides a convenient and highly sensitive method for functional characterization of 5-HT(3) receptors that is well suited for high-throughput screening...
  25. pmc Functional conservation of Pax6 regulatory elements in humans and mice demonstrated with a novel transgenic reporter mouse
    David A Tyas
    Genes and Development Group, Centre for Integrative Physiology, University of Edinburgh, Edinburgh EH8 9XD, UK
    BMC Dev Biol 6:21. 2006
    ..The sequence of the Pax6/PAX6 protein is identical in mice and humans and previous studies have shown structural conservation of the gene's regulatory regions...
  26. ncbi Immunogenicity and antigenicity of allogeneic amniotic epithelial transplants grafted to the cornea, conjunctiva, and anterior chamber
    Mingcong Wang
    Department of Ophthalmology, Nippon Medical School, Sendagi, Tokyo, Japan
    Invest Ophthalmol Vis Sci 47:1522-32. 2006
    ..To determine the immunogenic characterization of amniotic epithelium (AE), by examining the fate of allogeneic AE grafts heterotopically transplanted in the eye...
  27. ncbi Noninvasive imaging of molecular events with bioluminescent reporter genes in living subjects
    Pritha Ray
    Molecular Imaging Program at Stanford, Department of Radiology, Bio X Program, Stanford University, USA
    Methods Mol Biol 411:131-44. 2007
    ..Here we describe the methods and applications of firefly and renilla luciferases in molecular imaging using small animals...
  28. ncbi Light threshold-controlled cone alpha-transducin translocation
    Junping Chen
    Oklahoma Center for Neuroscience, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA
    Invest Ophthalmol Vis Sci 48:3350-5. 2007
    ....
  29. ncbi Influence of plasmid DNA topology on the transfection properties of DOTAP/DOPE lipoplexes
    Katrien Remaut
    Laboratory of General Biochemistry and Physical Pharmacy, Ghent University, Harelbekestraat 72, 9000 Ghent, Belgium
    J Control Release 115:335-43. 2006
    ..It seems that, compared to OC and linearized pDNA, SC pDNA is better suited to reach the perinuclear region, a prerequisite to become entrapped in the nuclei of the cells during cell division...
  30. ncbi Intraoperative localization of lymph node metastases with a replication-competent herpes simplex virus
    Prasad S Adusumilli
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    J Thorac Cardiovasc Surg 132:1179-88. 2006
    ..This study investigates the potential to identify lymph node metastases intraoperatively by using herpes-guided cancer cell-specific expression of green fluorescent protein...
  31. ncbi Second-generation triple reporter for bioluminescence, micro-positron emission tomography, and fluorescence imaging
    Aparna H Kesarwala
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Mol Imaging 5:465-74. 2006
    ..This second-generation triple reporter incorporating enhanced components enables bioluminescence, PET, and fluorescence imaging of cells and living animals...
  32. pmc Enhanced transfection of tumor cells in vivo using "Smart" pH-sensitive TAT-modified pegylated liposomes
    Amit A Kale
    Department of Pharmaceutical Sciences and Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Boston, MA 02115, USA
    J Drug Target 15:538-45. 2007
    ..This result can be considered as an important step in the development of tumor-specific stimuli-sensitive drug and gene delivery systems...
  33. pmc A double-transgenic mouse used to track migrating Schwann cells and regenerating axons following engraftment of injured nerves
    Ayato Hayashi
    Division of Plastic and Reconstructive Surgery, Washington University in St Louis School of Medicine, 660 South Euclid Ave Campus Box 8238, St Louis, MO 63110, USA
    Exp Neurol 207:128-38. 2007
    ..Live imaging of the double-transgenic thy1-CFP(23)/S100-GFP murine line enabled serial assessment of Schwann cell-axonal relationships in traumatic nerve injuries reconstructed with acellular nerve allografts...
  34. ncbi AAV-mediated expression targeting of rod and cone photoreceptors with a human rhodopsin kinase promoter
    Shahrokh C Khani
    Department of Ophthalmology, Ross Eye Institute, State University of New York, Buffalo, New York 14215, USA
    Invest Ophthalmol Vis Sci 48:3954-61. 2007
    ..RK, also known as G protein-coupled receptor kinase 1 (GRK1), is a component of the light adaptation pathway expressed in rods and cones...
  35. pmc Visualizing the dynamics of p21(Waf1/Cip1) cyclin-dependent kinase inhibitor expression in living animals
    Naoko Ohtani
    Institute for Genome Research, University of Tokushima, Tokushima 770 8503, Japan
    Proc Natl Acad Sci U S A 104:15034-9. 2007
    ..These data illustrate the unique utility of bioluminescence imaging in advancing our understanding of the timing and, hence, likely roles of specific gene expression in higher eukaryotes...
  36. ncbi Quantitative imaging of gene expression in individual bacterial cells by chemiluminescence
    Yun Zhang
    Ames Laboratory USDOE and Department of Chemistry, Iowa State University, Ames, Iowa 50011, USA
    Anal Chem 80:597-605. 2008
    ..In this scheme, the overall sensitivity of the system approaches the single protein molecule level. Quantitative studies of gene expression in BL21 and XLU102 bacteria can thus be performed...
  37. ncbi Imaging the effects of castration on bone turnover and hormone-independent prostate cancer colonization of bone
    N A Cross
    Biomedical Research Centre, Sheffield Hallam University, Sheffield, UK
    Prostate 68:1707-14. 2008
    ..We have tested this hypothesis using a xenograft model of early growth of prostate cancer in bone...
  38. ncbi Continuous delivery of D-luciferin by implanted micro-osmotic pumps enables true real-time bioluminescence imaging of luciferase activity in vivo
    Shimon Gross
    Molecular Imaging Center, Mallinckrodt Institute of Radiology, Department of Molecular Biology and Pharmacology, Washington University in St Louis, St Louis, MO 63110, USA
    Mol Imaging 6:121-30. 2007
    ..We conclude that implanted pumps provide reliable, prolonged substrate delivery for high temporal resolution BLI, traversing complications of repetitive substrate injections...
  39. pmc Increased level of extracellular ATP at tumor sites: in vivo imaging with plasma membrane luciferase
    Patrizia Pellegatti
    Department of Experimental and Diagnostic Medicine, Section of General Pathology, Interdisciplinary Center for the Study of Inflammation, University of Ferrara, Ferrara, Italy
    PLoS ONE 3:e2599. 2008
    ....
  40. ncbi In vivo optical bioluminescence imaging of collagen-supported cardiac cell grafts
    Ingo Kutschka
    Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, California, USA
    J Heart Lung Transplant 26:273-80. 2007
    ..In this study we introduce two new experimental models for longitudinal in vivo survival studies of cardiac cell grafts using optical bioluminescence imaging...
  41. ncbi 5-Fluorouracil ointment for the treatment of otitis media with effusion
    Shin Ichi Kanemaru
    Department of Otolaryngology Head and Neck Surgery Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Laryngoscope 117:215-9. 2007
    ..We estimated the depressant action of 5-FU on normal cell proliferation in vitro. In addition, clinically, we assessed whether 5-FU has the potential to prolong the effect of myringotomy...
  42. ncbi Degradation of pteridine reductase 1 (PTR1) enzyme during growth phase in the protozoan parasite Leishmania donovani
    Pranav Kumar
    Drug Target Discovery and Development Division, Central Drug Research Institute, Lucknow, India
    Exp Parasitol 116:182-9. 2007
    ..Therefore, this finding has importance to identify new target molecule like the proteasome for therapeutic intervention...
  43. ncbi Sorbitol causes preferential selection of Muller glial precursors from late retinal progenitor cells in vitro
    Tasneem Zahir
    Schepens Eye Research Institute, Harvard Medical School, Boston, MA, USA
    Mol Vis 12:1606-14. 2006
    ..The present study was undertaken to investigate the effects of sorbitol on in vitro selection of Müller glial precursors from expanded late retinal progenitor cells (RPCs)...
  44. ncbi Circulating monocytes engraft in the brain, differentiate into microglia and contribute to the pathology following meningitis in mice
    Marija Djukic
    Department of Neurology, Georg August University, Gottingen, Germany
    Brain 129:2394-403. 2006
    ..Thus, circulating cells entering the brain such as monocytes/macrophages might provide a potential cellular target for the treatment of the tissue damage following meningitis via peripheral cell therapy...
  45. ncbi Applications of molecular imaging in cancer gene therapy
    Meera Iyer
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles 90095, USA
    Curr Gene Ther 5:607-18. 2005
    ..Coupling PET to gene therapy of cancer has already been implemented in several clinical studies. This approach would help to improve the efficacy and safety of future gene therapy clinical trials...
  46. ncbi In vivo imaging with fluorescent proteins: the new cell biology
    Robert M Hoffman
    AntiCancer, Inc, 7917 Ostrow Street, San Diego, CA 92111, USA
    Acta Histochem 106:77-87. 2004
    ....
  47. ncbi Luminescence literature. GFP and imaging 2001 literature
    L J Kricka
    Luminescence 20:57-62. 2005
  48. ncbi In vivo optical imaging of human adenoid cystic carcinoma cell metastasis
    Tao Xiong
    The Key Laboratory of Biomedical Photonics of Ministry of Education, Huazhong University of Science and Technology, Wuhan, Hubei 430074, PR China
    Oral Oncol 41:709-15. 2005
    ..The construction of highly fluorescent and stable GFP transfectants of ACC-M has revealed the multi-organ metastatic capability of ACC-M cells through this optical imaging...
  49. pmc Quantitative methods to analyze subnuclear protein organization in cell populations with varying degrees of protein expression
    Ty C Voss
    University of Virginia Health Sciences Center, Departments of Medicine and Cell Biology, Charlottesville, Virginia 22908, USA
    J Biomed Opt 10:024011. 2005
    ..This integrated quantitative image analysis method will allow the rigorous comparison of different experimental cell populations that express variable levels of FP fusion proteins...
  50. ncbi Cells die with increased cytosolic ATP during apoptosis: a bioluminescence study with intracellular luciferase
    M V Zamaraeva
    Department of Cell Physiology, National Institute for Physiological Sciences, Okazaki 444 8585, Japan
    Cell Death Differ 12:1390-7. 2005
    ..Thus, it is suggested that the cells die with increased cytosolic ATP, and elevation of cytosolic ATP level is a requisite to the apoptotic cell death process...
  51. ncbi Transgenic mouse lines expressing synaptopHluorin in hippocampus and cerebellar cortex
    Rikita Araki
    Department of Developmental Biology and Neurosciences, Tohoku University Graduate School of Life Sciences, and CREST, JST, Sendai, Japan
    Genesis 42:53-60. 2005
    ..These transgenic lines are expected to facilitate morphological and physiological studies of presynaptic terminals in a variety of regions of the brain...
  52. ncbi Whole-body bioluminescent imaging of human uveal melanoma in a new mouse model of local tumor growth and metastasis
    Irene C Notting
    Department of Ophthalmology, Leiden University Medical Center, Albinusdreef 2, 2300 RC Leiden, The Netherlands
    Invest Ophthalmol Vis Sci 46:1581-7. 2005
    ..Therefore, the development of novel anticancer strategies is urgent, and more sensitive and less invasive methods of detecting and monitoring in vivo tumor growth and metastatic disease in cancer models are needed...
  53. ncbi Development of a fluorescent reporter to assess iron regulatory protein activity in living cells
    Rebecca J Henderson
    Department of Pharmacology, College of Medicine, Pennsylvania State University, 500 University Drive, Hershey, Pennsylvania 17033, USA
    Biochim Biophys Acta 1743:162-8. 2005
    ....
  54. ncbi Time course of mycobacterial infection of dendritic cells in the lungs of intranasally infected mice
    R Reljic
    Department for Oral Medicine and Pathology, Guy s Campus of King s College, London, UK
    Tuberculosis (Edinb) 85:81-8. 2005
    ..In this paper we investigated if their early infection in the lungs represents a plausible alternative to cross-priming with mycobacterial antigens acquired from infected macrophages...
  55. ncbi ABCG2/BCRP expression modulates D-Luciferin based bioluminescence imaging
    Yimao Zhang
    Russell H Morgan Department of Radiology, The Johns Hopkins Bloomberg School of Public Health, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    Cancer Res 67:9389-97. 2007
    ..These findings highlight the need to consider ABCG2/BCRP effects during d-luciferin-based BLI and suggest novel high throughput methods for identifying new ABCG2/BCRP inhibitors...
  56. ncbi Glycinergic neurons expressing enhanced green fluorescent protein in bacterial artificial chromosome transgenic mice
    Hanns Ulrich Zeilhofer
    Department of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen Nurnberg, 91054 Erlangen, Germany
    J Comp Neurol 482:123-41. 2005
    ....
  57. ncbi Development of the "Cell Chip": a new in vitro alternative technique for immunotoxicity testing
    Erik Ullerås
    Department of Genetics and Pathology, Uppsala University, Uppsala, Sweden
    Toxicology 206:245-56. 2005
    ..The major advantage of this approach is the possibility to apply this test in high throughput screening of high number of compounds for their well defined biological activity...
  58. ncbi Botulinum neurotoxin type D enables cytosolic delivery of enzymatically active cargo proteins to neurones via unfolded translocation intermediates
    Steffen Bade
    Institute fur Biochemie, Medizinische Hochschule Hannover, Hannover, Germany
    J Neurochem 91:1461-72. 2004
    ..Thus, enzymatically inactive clostridial neurotoxins may serve as effective, safe carriers for delivering proteins in functionally active form to the cytosol of neurones...
  59. ncbi Neurally selected embryonic stem cells induce tumor formation after long-term survival following engraftment into the subretinal space
    Stefan Arnhold
    Department of Anatomy I, University of Cologne, Cologne, Joseph Stelzmann Strasse 9, 50931 Koln, Germany
    Invest Ophthalmol Vis Sci 45:4251-5. 2004
    ..To determine whether transplantation of embryonic stem (ES) cells into the subretinal space of rhodopsin-knockout mice has a tumorigenic effect...
  60. ncbi Alteration of neuronal firing properties after in vivo experience in a FosGFP transgenic mouse
    Alison L Barth
    Department of Biological Sciences and Center for the Neural Basis of Cognition, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA
    J Neurosci 24:6466-75. 2004
    ..In addition, because activated neurons can be functionally characterized, this tool may enable the development of better pharmaceuticals that directly affect the neurons involved in disease states...
  61. pmc Dendritic spine abnormalities in amyloid precursor protein transgenic mice demonstrated by gene transfer and intravital multiphoton microscopy
    Tara L Spires
    Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Neurosci 25:7278-87. 2005
    ..Decreased spine density will likely contribute to altered neural system function and behavioral impairments observed in Tg2576 mice...
  62. ncbi Visualizing levels of osteoblast differentiation by a two-color promoter-GFP strategy: Type I collagen-GFPcyan and osteocalcin-GFPtpz
    I Bilic-Curcic
    Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, Connecticut
    Genesis 43:87-98. 2005
    ..It should be useful to identify and isolate populations of cells within an osteoblast lineage as they progress through stages of differentiation...
  63. ncbi Hepatocyte growth factor induces angiogenesis in injured lungs through mobilizing endothelial progenitor cells
    Kota Ishizawa
    Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, Sendai, Miyagi 980 8574, Japan
    Biochem Biophys Res Commun 324:276-80. 2004
    ..These complex effects induced by HGF orchestrate pulmonary regeneration in emphysematous lung parenchyma...
  64. ncbi Noninvasive visualization of molecular events in the mammalian zygote
    Kazuo Yamagata
    Graduate School of Life and Environmental Science, and Institute of Applied Biochemistry, University of Tsukuba, Tsukuba Science City, Ibaraki, Japan
    Genesis 43:71-9. 2005
    ....
  65. ncbi Mechanisms of neuropeptide Y, peptide YY, and pancreatic polypeptide inhibition of identified green fluorescent protein-expressing GABA neurons in the hypothalamic neuroendocrine arcuate nucleus
    Claudio Acuna-Goycolea
    Department of Neurosurgery, Yale University, New Haven, Connecticut 06520, USA
    J Neurosci 25:7406-19. 2005
    ..Together, these results show that the family of neuropeptide Y modulators reduces the activity of inhibitory GABA neurons in the ARC by multiple presynaptic and postsynaptic mechanisms...
  66. pmc Reduction of astrogliosis by early treatment of pneumococcal meningitis measured by simultaneous imaging, in vivo, of the pathogen and host response
    Jagath L Kadurugamuwa
    Clorox Services Company, 7200 Johnson Dr, Pleasanton, CA 94588, USA
    Infect Immun 73:7836-43. 2005
    ..This model has potential for simultaneous multiparameter monitoring and testing of therapies that target the pathogen or host response to prevent neuronal injury and recovery...
  67. pmc Virally-directed fluorescent imaging (VFI) can facilitate endoscopic staging
    P S Adusumilli
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Surg Endosc 20:628-35. 2006
    ..We sought to determine the feasibility of GFP-guided imaging technology in the intraoperative detection of small tumor nodules...
  68. pmc Extended Stokes shift in fluorescent proteins: chromophore-protein interactions in a near-infrared TagRFP675 variant
    Kiryl D Piatkevich
    Department of Anatomy and Structural Biology and Gruss Lipper Biophotonics Center, Bronx, New York 10461, United States
    Sci Rep 3:1847. 2013
    ..Based on the spectroscopic, biochemical, and structural analysis we suggest that the rearrangement of the hydrogen bond interactions between the chromophore and the protein matrix is responsible for the TagRFP675 spectral properties...
  69. ncbi An effective approach to enhanced energy-transfer efficiency from up-converting phosphors and increased assay sensitivity
    Yunxia Yuan
    Key Laboratory of Analytical Chemistry for Biology and Medicine, Ministry of Education, College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, P R China
    Chem Commun (Camb) 48:7510-2. 2012
    ..The energy transfer efficiency from up-converting donors was significantly enhanced by constructing beacon sensors, which led to increased sensitivities in DNA recognition and protein determination...
  70. ncbi Measurement of cell respiration and oxygenation in standard multichannel biochips using phosphorescent O2-sensitive probes
    Alina V Kondrashina
    Biochemistry Department, University College Cork, Cork, Ireland
    Analyst 138:4915-21. 2013
    ..It also allows re-perfusion and multiple treatments of cells and multi-parametric analyses in conjunction with other probes. Optical measurements are conducted on standard fluorescence readers and microscopes. ..
  71. ncbi Endogenous bone-marrow-derived stem cells contribute only a small proportion of regenerated myocardium in the acute infarction model
    Shinya Fukuhara
    Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center, Osaka, 565 8565, Japan
    J Heart Lung Transplant 24:67-72. 2005
    ..In this study, we verified the proportional contribution of cells from bone marrow (BM) and from non-bone marrow (n-BM) in regenerating neomyocardium after myocardial infarction...
  72. ncbi Interdigitated microelectrode array-coupled bipolar semiconductor photodiode array (IMEA-PDA) microchip for on-chip electrochemiluminescence detection
    Sukdeb Pal
    Research Institute of Pharmaceutical Sciences and College of Pharmacy, Seoul National University, Seoul 151 742, South Korea
    Biomed Microdevices 11:971-80. 2009
    ..These in turn bring in speed and statistical confidence in analysis. The IMEA-PDA microchip system has the potential to be used as a versatile and highly compact chemical analysis tool for chemical sensing and metrology applications...
  73. ncbi Isoquinoline-based lanthanide complexes: bright NIR optical probes and efficient MRI agents
    Fabien Caillé
    Centre de Biophysique Moleculaire, UPR 4301 CNRS, rue Charles Sadron, 45071 Orleans, France
    Inorg Chem 51:2522-32. 2012
    ....
  74. ncbi Clofibrate and dalargin increase luminol-dependent chemiluminescence of mouse blood
    V M Mushtakova
    N N Semenov Institute of Chemical Physics, Russian Academy of Sciences, Moscow
    Bull Exp Biol Med 144:317-8. 2007
    ..Their combined use several-fold potentiated this effect. It is expected that combined use of hypolipidemics and polypeptides will open a new trend in the search for stimulators of oxygen-dependent nonspecific immunity...
  75. pmc Novel differences in the expression of inflammation-associated genes between mid- and late-gestational dermal fibroblasts
    Brian C Wulff
    Department of Pathology, The Ohio State University, Columbus, Ohio 43210, USA
    Wound Repair Regen 21:103-12. 2013
    ..Furthermore, baseline differences in the expression of inflammatory genes by fibroblasts in E15 and E18 skin may contribute to inflammation and scar formation late in gestation...
  76. pmc Optimizing sensitization processes in dinuclear luminescent lanthanide oligomers: selection of rigid aromatic spacers
    Jean François Lemonnier
    Department of Inorganic, Analytical and Applied Chemistry, University of Geneva, 30 quai E Ansermet, CH 1211 Geneva 4, Switzerland
    J Am Chem Soc 133:16219-34. 2011
    ..A simple interpretation of the complete set of rate constants characterizing the energy migration mechanisms provides straightforward objective criteria for the selection of [Eu2(L4)(hfac)6] as the most promising building block...
  77. pmc Assessment of golgi apparatus versus plasma membrane-localized multi-drug resistance-associated protein 1
    Allyn M Kaufmann
    Department of Pharmaceutical Chemistry, The University of Kansas, Lawrence, KS 66047, USA
    Mol Pharm 5:787-94. 2008
    ..Additionally, we show that a number of human leukemic cell lines appear to have an inefficient Golgi apparatus to PM secretory pathway that could be responsible for the Golgi localization of MRP1...
  78. ncbi A novel luminol chemiluminescent method catalyzed by silver/gold alloy nanoparticles for determination of anticancer drug flutamide
    Mohammad Javad Chaichi
    Faculty of Chemistry, Mazandaran University, Babolsar 47416 95447, Iran Electronic address
    Spectrochim Acta A Mol Biomol Spectrosc 116:594-8. 2013
    ..This work is introduced as a new method for the determination of flutamide in commercial tablets. Box-Behnken experimental design is applied to investigate and validate the CL measurement parameters...
  79. ncbi Bioactive luminescent transition-metal complexes for biomedical applications
    Dik Lung Ma
    Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China
    Angew Chem Int Ed Engl 52:7666-82. 2013
    ....
  80. ncbi IL-10 secretion increases signal persistence of HEMA-MMA-microencapsulated luciferase-modified CHO fibroblasts in mice
    Martin Surzyn
    Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada
    Tissue Eng Part A 15:127-36. 2009
    ..Longer duration effects require further investigation to extend this proof-of-concept study...
  81. pmc Aqueous Ln(III) luminescence agents derived from a tasty precursor
    Christoph J Jocher
    Department of Chemistry, University of California, Berkeley, California 94720, USA
    Inorg Chem 47:7951-3. 2008
    ..04%), which can be rationalized by the similar energy of the ligand triplet state and the Eu(III) (5)D0 emissive level. Instead, sensitized emission from the Yb(III) and Nd(III) cations was observed, which emit in the NIR...
  82. pmc Phosphorescent imaging of living cells using a cyclometalated iridium (III) complex
    Dik Lung Ma
    Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China
    PLoS ONE 8:e55751. 2013
    ..The iridium(III) solvato complex [Ir(phq)2(H2O]2)] preferentially stains the cytoplasm of both live and dead cells with a bright luminescence...
  83. pmc Stringent doxycycline-dependent control of gene activities using an episomal one-vector system
    Georg W Bornkamm
    GSF Institut für Klinische Molekularbiologie und Tumorgenetik, Marchioninistrasse 25, D 81377 Munchen, Germany
    Nucleic Acids Res 33:e137. 2005
    ..Tight down regulation is achieved through binding of the silencer tTS(KRAB) to P(tet)bi-1 in the absence of Dox. Addition of Dox releases repression and via binding of rtTA2(S)-M2 activates P(tet)bi-1...
  84. ncbi Spiro-configured bipolar host materials for highly efficient electrophosphorescent devices
    Sung Yu Ku
    Department of Chemistry, National Taiwan University, Taipei, Taiwan
    Chem Asian J 7:133-42. 2012
    ..65, 0.35) and remarkably high efficiencies of 20.3 % (21 cd A(-1)) and 13.5 Lm W(-1) at a practical brightness of 1000 cd m(-2)...
  85. pmc Concentration-independent pH detection with a luminescent dimetallic Eu(III)-based probe
    Jeremiah D Moore
    Department of Chemistry, Wayne State University, Detroit, Michigan 48202, USA
    J Am Chem Soc 134:17372-5. 2012
    ..Modulation of the luminescence-decay rate is independent from the concentration of Eu(III), which we expect to be useful in the non-invasive imaging of in vivo pH...
  86. ncbi The quantum cutting of Tb(3+) in Ca(6)Ln(2)Na(2)(PO(4))(6)F(2) (Ln = Gd, La) under VUV-UV excitation: with and without Gd(3+)
    Mubiao Xie
    MOE Laboratory of Bioinorganic and Synthetic Chemistry, State Key Laboratory of Optoelectronic Materials and Technologies, School of Chemistry and Chemical Engineering, Sun Yat Sen University, Guangzhou 510275, PR China
    Inorg Chem 49:11317-24. 2010
    ..In addition, the energy transfer process from Gd(3+) to Tb(3+) as well as (5)D(3)-(5)D(4) cross relaxation was investigated and discussed in terms of luminescence spectra and decay curves...
  87. ncbi Adsorption characteristics of spiropyran-modified cationic surfactants at the silica/aqueous solution interface
    Kenichi Sakai
    Department of Pure and Applied Chemistry in Faculty of Science and Technology and Research Institute for Science and Technology, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278 8510, Japan
    Langmuir 26:9283-8. 2010
    ..By taking the in situ and ex situ color changes into consideration, it seems likely that the photoisomerization occurs reversibly even after surfactant adsorption on silica...
  88. ncbi Determination of superoxide dismutase and SOD-mimetic activities by a chemical system: Co2/H2O2/lucigenin
    T V Zhidkova
    Faculty of Fundamental Medicine, Lomonosov Moscow State University, Moscow, Russia
    Anal Bioanal Chem 401:381-6. 2011
    ..A technique of tissue sample preparation with the use of thermal inactivation of interfering proteins at 60 °C was used. The method was successfully applied for comparison of the efficiency of SOD mimetics...
  89. ncbi Photoluminescent biocompatible silicon nanoparticles for cancer theranostic applications
    Liubov A Osminkina
    Department of Physics, Lomonosov Moscow State University, 119992 Moscow, Russia
    J Biophotonics 5:529-35. 2012
    ..These properties of SiNPs are discussed in view of possible applications in theranostics (both in therapy and in diagnostics)...
  90. ncbi Microflow-injection chemiluminescence of luminol and hypochlorite enhanced by phloxine B
    Xiaoli Song
    Institute of Microanalytical Systems, Department of Chemistry, Zhejiang University, Hangzhou, People s Republic of China
    Luminescence 28:16-22. 2013
    ..2% (n = 10) for 2.5 µmol/L hypochlorite. The sample consumption was only 2 μL, with a sample throughput of 90/h. The method has been used for determining trace amounts of hypochlorite in water samples with satisfactory results...
  91. ncbi A lanthanide-complex-based ratiometric luminescent probe specific for peroxynitrite
    Cuihong Song
    Department of Instrumentation and Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China
    Chemistry 16:6464-72. 2010
    ..The results demonstrated the efficacy and advantages of the new ratiometric luminescence probe for highly sensitive luminescence bioimaging application...
  92. ncbi Influence of three scan spray systems on human gingival fibroblasts
    Ines Willershausen
    Department of Operative Dentistry, University Medical Center of Johannes Gutenberg University, Mainz, Germany
    Quintessence Int 43:e67-72. 2012
    ..The aim of this in vitro study was to investigate the influence of three different scan sprays on the proliferation, viability, and adenylate kinase (ADK) release of human fibroblasts...
  93. ncbi Synthesis, radii dependent self-assembly crystal structures and luminescent properties of rare earth (III) complexes with a tripodal salicylic derivative
    Ya wen Wang
    State Key Laboratory of Applied Organic Chemistry and College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000, China
    Dalton Trans 39:9013-21. 2010
    ..The photophysical properties of the Eu and Tb complexes are investigated in the solid state at room temperature...
  94. ncbi A set of GFP organelle marker lines for intracellular localization studies in Medicago truncatula
    Bin Luo
    USDA ARS Children s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, 1100 Bates St, Houston, TX 77030 2600, USA
    Plant Sci 188:19-24. 2012
    ..Moreover, this set of marker lines is compatible with both transient and stable expression systems. Thus, this marker set should prove to be a useful resource for the M. truncatula research community...
  95. ncbi Effect of surface modification on photoluminescence properties of Y3Al5O12:Ce3+, Gd3+ nano-phosphors
    Jie Li
    Key Laboratory of Interface Science and Engineering in Advanced Materials Taiyuan University of Technology, Ministry of Education, Taiyuan, PR China
    Spectrochim Acta A Mol Biomol Spectrosc 78:1310-4. 2011
    ....
  96. ncbi Functionalized 1,2,3-triazoles as building blocks for photoluminescent POLOs (polymers of oligomers) of copper(I)
    Shi Qiang Bai
    Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore, 117543
    Dalton Trans 39:2631-6. 2010
    ..Complex 3 shows a 2-D (4, 4) net with the stair-step Cu(4)I(4) as node and L3 as a building block. All three complexes exhibit photoluminescence...
  97. pmc TMEM106B, the risk gene for frontotemporal dementia, is regulated by the microRNA-132/212 cluster and affects progranulin pathways
    Alice S Chen-Plotkin
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 32:11213-27. 2012
    ..Evidence for this pathogenic cascade includes the striking convergence of two independent, genomic-scale screens on a microRNA:mRNA regulatory pair. Our findings open novel directions for elucidating miR-based therapies in FTLD-TDP...
  98. ncbi Synthesis of chlorin-sensitized near infrared-emitting lanthanide complexes
    Johanna Laakso
    Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, SE 10691, Stockholm, Sweden
    Inorg Chem 51:10366-74. 2012
    ..The complexes benefit from dual chlorin (610-639 nm) and lanthanide (980 or 1065 nm for Yb- or Nd-complexes, respectively) emission in the biologically relevant red and near IR region of the spectrum...
  99. ncbi Aggregation-induced emission
    Yuning Hong
    Department of Chemistry, Nano Science and Technology Program, Bioengineering Graduate Program, Institute of Molecular Functional Materials, The Hong Kong University of Science and Technology HKUST, Clear Water Bay, Kowloon, Hong Kong, China
    Chem Soc Rev 40:5361-88. 2011
    ..Technological, especially optoelectronic and biological, applications of the AIE systems are exemplified to illustrate how the novel AIE effect can be utilized for high-tech innovations (183 references)...
  100. ncbi Maxillary sinus floor elevation using a tissue engineered bone complex with BMP-2 gene modified bMSCs and a novel porous ceramic scaffold in rabbits
    X Juan Sun
    Ninth People s Hospital Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai Key Laboratory of Stomatology, Shanghai 200011, China
    Arch Oral Biol 55:195-202. 2010
    ....
  101. ncbi Lanthanide directed self-assembly formations of Tb(III) and Eu(III) luminescent complexes from tryptophan based pyridyl amide ligands
    Christophe Lincheneau
    School of Chemistry, Centre for Synthesis and Chemical Biology, Trinity College Dublin, Dublin 2, Ireland
    Chem Commun (Camb) 47:7119-21. 2011
    ....

Research Grants20

  1. Improved Safe Alternative to Semiconductor Quantum Dots
    ROBERT BOLSKAR; Fiscal Year: 2005
    Quantum dots are recognized as the core materials of a new generation luminescent agents for biolabelling applications. This project will establish proof-of-concept for a new class of non-toxic, metal free quantum dot-like materials...
  2. Inhibitors of 5alpha-reductase for acne therapy
    Lingna Li; Fiscal Year: 2002
    ..PROPOSED COMMERCIAL APPLICATIONS: Liposomal 4-MA will be developed as a topical selectively targeted therapeutic for acne for which they should be a very market. ..
  3. Adenoviral GFP targeting of metastatic human tumors using multiple delivery route
    Hiroyuki Kishimoto; Fiscal Year: 2008
    ..Having obtained these results, we can move forward in the Phase II grant application with experiments to bring OBP-401 to the clinic for use in cancer surgery in human patients. [unreadable] [unreadable] [unreadable]..
  4. Orthotopic models of tumor angiogenesis and blood flow
    Meng Yang; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  5. Therapeutic hair follicle-derived neurospheres
    Meng Yang; Fiscal Year: 2007
    ..Human hair- follicle bulge cells will be further characterized and developed for therapeutic potential for nerve regeneration in Phase III. [unreadable]..
  6. Structure-based Directed Evolution of Fast-Maturing GFPs
    Rebekka Wachter; Fiscal Year: 2007
    ..In more general terms, a fast-maturing GFP would aid in the development of therapies for a very large number of disease states including neurodegenerative and cancerous disorders. [unreadable] [unreadable] [unreadable]..
  7. Dual-color tumor-host imaging models
    Meng Yang; Fiscal Year: 2007
    ..These models have significant commercial potential for discovery and development of stroma-targeted and anti-angiogenesis drugs. [unreadable] [unreadable] [unreadable]..
  8. Targeted tumoricidal bacteria
    Ming Zhao; Fiscal Year: 2007
    ..Future human trials of the tumor-killing bacteria can be held after the Phase I and Phase II grant periods are completed. [unreadable] [unreadable] [unreadable]..
  9. Imageable tumor-targeting bacteria
    Ming Zhao; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  10. Enzyme therapy for hyperhomocysteinemia
    Yuying Tan; Fiscal Year: 2005
    ..Phase II results will lead to an IND for MEGC-PEG-rMETase for end stage renal disease patients and other patients with intractable hyperhomocysteinemia and high cardiovascular disease mortality. ..
  11. Identifying targets for diagnosing oral candidiasis
    David Schofield; Fiscal Year: 2005
    ..Since Candida species are the most important fungal pathogen of the oral cavity, the rapid and accurate diagnosis of oral candidiasis using novel disease biomarkers will significantly improve oral health. ..
  12. RHOMOCYCSTEINASE FOR HOMOCYSTEINE ASSAY
    Yuying Tan; Fiscal Year: 2002
    ..The tHCY enzymatic kits for these applications will be ready for commercial launch at this point. PROPOSED COMMERCIAL APPLICATION: Not Available ..
  13. Discovery of novel fluorescent reporter genes
    Ming Zhao; Fiscal Year: 2004
    ..Reporters with spectral properties that can be used for whole-body imaging of tumors in the lung and their metastases will be candidates for further development for numerous applications of multi-color imaging. ..
  14. Design of Gene Delivery System to Target Hepatocytes
    Mark Davis; Fiscal Year: 2008
    ..The long-term objective of our proposal is to design and engineer a generalized, synthetic system for ultimately delivering nucleic acid-based therapeutics to hepatocytes in humans. ..
  15. Transcriptional Regulation of Rhodopsin Kinase Gene
    SHAHROKH KHANI; Fiscal Year: 2006
    ..These novel candidate genes may also participate in the pathogenesis of human retinal degenerations. ..
  16. Differentiation Potential of Adult Rat Stem Cells
    JEFFERY SPEES; Fiscal Year: 2005
    ..3. To determine the engraftment and differentiation potential of the stem cell sub-populations in a rat model of monocrotaline-induced pulmonary hypertension. ..
  17. Imaging Vaccina Viral-Host Pathogenesis
    Gary Luker; Fiscal Year: 2007
    ..Collectively, the research is expected to facilitate the development of improved vaccines and treatments for smallpox, thereby enhancing our ability to prevent the use of smallpox for bioterrorism. [unreadable] [unreadable] [unreadable]..
  18. Glycophorin A Dimers to Probe Membranes: A 2D-IR Study
    LOUISE SINKS; Fiscal Year: 2008
    ..Since many transmembrane proteins critical to cell function, understanding the interplay between membrane environment and protein structure is vitallv important. ..
  19. A Unified Reporter Gene for Multi-Modality Imaging
    Jianghong Rao; Fiscal Year: 2005
    ..abstract_text> ..