contrast media

Summary

Summary: Substances used in radiography that allow visualization of certain tissues.

Top Publications

  1. ncbi The use of contrast-enhanced magnetic resonance imaging to identify reversible myocardial dysfunction
    R J Kim
    Feinberg Cardiovascular Research Institute, and Department of Medicine, Northwestern University Medical School, Chicago, IL 60611 3008, USA
    N Engl J Med 343:1445-53. 2000
  2. doi Magnetic iron oxide nanoparticles: synthesis, stabilization, vectorization, physicochemical characterizations, and biological applications
    Sophie Laurent
    Department of General, Organic, and Biomedical Chemistry, NMR and Molecular Imaging Laboratory, University of Mons Hainaut, B 7000 Mons, Belgium
    Chem Rev 108:2064-110. 2008
  3. ncbi Estimating kinetic parameters from dynamic contrast-enhanced T(1)-weighted MRI of a diffusable tracer: standardized quantities and symbols
    P S Tofts
    Department of Clinical Neurology, Institute of Neurology, University College London, London WC1N 3BG, United Kingdom
    J Magn Reson Imaging 10:223-32. 1999
  4. pmc Renal clearance of quantum dots
    Hak Soo Choi
    Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Room SL B05, Boston, Massachusetts 02215, USA
    Nat Biotechnol 25:1165-70. 2007
  5. ncbi Contrast induced nephropathy: updated ESUR Contrast Media Safety Committee guidelines
    Fulvio Stacul
    S C Radiologia Ospedale Maggiore, Piazza Ospitale 1, 34134 Tieste, Italy
    Eur Radiol 21:2527-41. 2011
  6. ncbi Hospital-acquired renal insufficiency
    Kevin Nash
    Evanston Hospital, Evanston, IL, USA
    Am J Kidney Dis 39:930-6. 2002
  7. ncbi Equilibrium contrast cardiovascular magnetic resonance for the measurement of diffuse myocardial fibrosis: preliminary validation in humans
    Andrew S Flett
    Department of Medicine, University College London Hospitals National Health Service Trust, The Heart Hospital, 16 18 Westmoreland St, London W1G 8PH, United Kingdom
    Circulation 122:138-44. 2010
  8. ncbi A simple risk score for prediction of contrast-induced nephropathy after percutaneous coronary intervention: development and initial validation
    Roxana Mehran
    Cardiovascular Research Foundation, Columbia University Medical Center, New York, New York 10022, USA
    J Am Coll Cardiol 44:1393-9. 2004
  9. pmc T1 mapping of the myocardium: intra-individual assessment of the effect of field strength, cardiac cycle and variation by myocardial region
    Nadine Kawel
    Radiology and Imaging Sciences and Molecular Biomedical Imaging Laboratory, National Institute of Biomedical Imaging and Bioengineering, Bethesda, MD, USA
    J Cardiovasc Magn Reson 14:27. 2012
  10. pmc Extracellular volume imaging by magnetic resonance imaging provides insights into overt and sub-clinical myocardial pathology
    Martin Ugander
    Cardiovascular and Pulmonary Branch, National Heart, Lung and Blood Institute, National Institutes of Health, US Department of Health and Human Services, 10 Center Drive, Bethesda, MD 20892 1061, USA
    Eur Heart J 33:1268-78. 2012

Detail Information

Publications374 found, 100 shown here

  1. ncbi The use of contrast-enhanced magnetic resonance imaging to identify reversible myocardial dysfunction
    R J Kim
    Feinberg Cardiovascular Research Institute, and Department of Medicine, Northwestern University Medical School, Chicago, IL 60611 3008, USA
    N Engl J Med 343:1445-53. 2000
    ..We hypothesized that the results of contrast-enhanced MRI can be used to predict whether regions of abnormal ventricular contraction will improve after revascularization in patients with coronary artery disease...
  2. doi Magnetic iron oxide nanoparticles: synthesis, stabilization, vectorization, physicochemical characterizations, and biological applications
    Sophie Laurent
    Department of General, Organic, and Biomedical Chemistry, NMR and Molecular Imaging Laboratory, University of Mons Hainaut, B 7000 Mons, Belgium
    Chem Rev 108:2064-110. 2008
  3. ncbi Estimating kinetic parameters from dynamic contrast-enhanced T(1)-weighted MRI of a diffusable tracer: standardized quantities and symbols
    P S Tofts
    Department of Clinical Neurology, Institute of Neurology, University College London, London WC1N 3BG, United Kingdom
    J Magn Reson Imaging 10:223-32. 1999
    ..We relate these quantities to previously published work from our groups; our future publications will refer to these standardized terms, and we propose that these be adopted as international standards...
  4. pmc Renal clearance of quantum dots
    Hak Soo Choi
    Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Room SL B05, Boston, Massachusetts 02215, USA
    Nat Biotechnol 25:1165-70. 2007
    ..5 nm resulted in rapid and efficient urinary excretion and elimination of quantum dots from the body. This study provides a foundation for the design and development of biologically targeted nanoparticles for biomedical applications...
  5. ncbi Contrast induced nephropathy: updated ESUR Contrast Media Safety Committee guidelines
    Fulvio Stacul
    S C Radiologia Ospedale Maggiore, Piazza Ospitale 1, 34134 Tieste, Italy
    Eur Radiol 21:2527-41. 2011
    The Contrast Media Safety Committee (CMSC) of the European Society of Urogenital Radiology (ESUR) has updated its 1999 guidelines on contrast medium-induced nephropathy (CIN).
  6. ncbi Hospital-acquired renal insufficiency
    Kevin Nash
    Evanston Hospital, Evanston, IL, USA
    Am J Kidney Dis 39:930-6. 2002
    ..2% of patients. Decreased renal perfusion, medications, surgery, and radiographic contrast media were the most common causes of hospital-acquired renal insufficiency (HARI). The overall mortality rate was 19...
  7. ncbi Equilibrium contrast cardiovascular magnetic resonance for the measurement of diffuse myocardial fibrosis: preliminary validation in humans
    Andrew S Flett
    Department of Medicine, University College London Hospitals National Health Service Trust, The Heart Hospital, 16 18 Westmoreland St, London W1G 8PH, United Kingdom
    Circulation 122:138-44. 2010
    ..We have developed a robust and noninvasive technique, equilibrium contrast CMR (EQ-CMR) to quantify diffuse fibrosis and have validated it against the current gold standard of surgical myocardial biopsy...
  8. ncbi A simple risk score for prediction of contrast-induced nephropathy after percutaneous coronary intervention: development and initial validation
    Roxana Mehran
    Cardiovascular Research Foundation, Columbia University Medical Center, New York, New York 10022, USA
    J Am Coll Cardiol 44:1393-9. 2004
    ..We sought to develop a simple risk score of contrast-induced nephropathy (CIN) after percutaneous coronary intervention (PCI)...
  9. pmc T1 mapping of the myocardium: intra-individual assessment of the effect of field strength, cardiac cycle and variation by myocardial region
    Nadine Kawel
    Radiology and Imaging Sciences and Molecular Biomedical Imaging Laboratory, National Institute of Biomedical Imaging and Bioengineering, Bethesda, MD, USA
    J Cardiovasc Magn Reson 14:27. 2012
    ..The purpose of this study was to evaluate acquisition factors that may result in variation of measured T1 time and ECV including magnetic field strength, cardiac phase and myocardial region...
  10. pmc Extracellular volume imaging by magnetic resonance imaging provides insights into overt and sub-clinical myocardial pathology
    Martin Ugander
    Cardiovascular and Pulmonary Branch, National Heart, Lung and Blood Institute, National Institutes of Health, US Department of Health and Human Services, 10 Center Drive, Bethesda, MD 20892 1061, USA
    Eur Heart J 33:1268-78. 2012
    ....
  11. ncbi Iron oxide MR contrast agents for molecular and cellular imaging
    Jeff W M Bulte
    Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    NMR Biomed 17:484-99. 2004
    ....
  12. pmc Non-contrast T1-mapping detects acute myocardial edema with high diagnostic accuracy: a comparison to T2-weighted cardiovascular magnetic resonance
    Vanessa M Ferreira
    Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK
    J Cardiovasc Magn Reson 14:42. 2012
    ..Quantitative T1-mapping is also sensitive to changes in free water content. We hypothesized that T1-mapping would have a higher diagnostic performance in detecting acute edema than dark-blood and bright-blood T2w-CMR...
  13. ncbi Comparison of magnetic properties of MRI contrast media solutions at different magnetic field strengths
    Martin Rohrer
    Global Business Unit Diagnostic Imaging, Schering AG, Berlin, Germany
    Invest Radiol 40:715-24. 2005
    To characterize and compare commercially available contrast media (CM) for magnetic resonance imaging (MRI) in terms of their relaxivity at magnetic field strengths ranging from 0.47 T to 4...
  14. ncbi Contrast-induced acute kidney injury
    Peter A McCullough
    Divisions of Cardiology, Nutrition, and Preventive Medicine, William Beaumont Hospital, Royal Oak, Michigan 48073, USA
    J Am Coll Cardiol 51:1419-28. 2008
    Cardiac angiography and coronary/vascular interventions depend on iodinated contrast media and consequently pose the risk of contrast-induced acute kidney injury (AKI)...
  15. ncbi Modified Look-Locker inversion recovery (MOLLI) for high-resolution T1 mapping of the heart
    Daniel R Messroghli
    BHF Cardiac MRI Unit, Leeds General Infirmary, Leeds, UK
    Magn Reson Med 52:141-6. 2004
    ..The region of infarction was clearly visualized. MOLLI provides high-resolution T1 maps of human myocardium in native and post-contrast situations within a single breath-hold...
  16. pmc Shortened Modified Look-Locker Inversion recovery (ShMOLLI) for clinical myocardial T1-mapping at 1.5 and 3 T within a 9 heartbeat breathhold
    Stefan K Piechnik
    University of Oxford Centre for Clinical Magnetic Resonance Research, Department of Cardiovascular Medicine, John Radcliffe Hospital, Oxford, UK
    J Cardiovasc Magn Reson 12:69. 2010
    ..In this work we propose and validate a novel, clinically applicable, pulse sequence for myocardial T1-mapping that is compatible with typical limits for end-expiration breath-holding in patients...
  17. pmc Assessment of myocardial fibrosis with cardiovascular magnetic resonance
    Nathan Mewton
    Division of Cardiology, Johns Hopkins University, Baltimore, Maryland 21287 0409, USA
    J Am Coll Cardiol 57:891-903. 2011
    ..As such, CMR could be integrated in the monitoring and therapeutic management of a large number of patients. This review summarizes the advantages and limitations of CMR for the assessment of myocardial fibrosis...
  18. ncbi Recent advances in iron oxide nanocrystal technology for medical imaging
    Claire Corot
    Guerbet Research, BP 57400, 95943 Roissy CDG, France
    Adv Drug Deliv Rev 58:1471-504. 2006
    ..Stem cell migration and immune cell trafficking, as well as targeted iron oxide nanoparticles for molecular imaging studies, are at the stage of proof of concept, mainly in animal models...
  19. ncbi Optimization and validation of a fully-integrated pulse sequence for modified look-locker inversion-recovery (MOLLI) T1 mapping of the heart
    Daniel R Messroghli
    Cardiac MRI Unit, Franz Volhard Klinik, Charite Campus Buch, Universitatsmedizin Berlin, HELIOS Klinikum Berlin, Germany
    J Magn Reson Imaging 26:1081-6. 2007
    ..To optimize and validate a fully-integrated version of modified Look-Locker inversion-recovery (MOLLI) for clinical single-breathhold cardiac T1 mapping...
  20. pmc MicroCT for comparative morphology: simple staining methods allow high-contrast 3D imaging of diverse non-mineralized animal tissues
    Brian D Metscher
    Department of Theoretical Biology, Gerd Müller, University of Vienna, Althanstrasse 14, 1090 Austria
    BMC Physiol 9:11. 2009
    ..Although osmium staining and a few other techniques have been used for contrast enhancement, generally useful methods for microCT imaging for comparative morphology are still lacking...
  21. ncbi Iodixanol versus low-osmolar contrast media for prevention of contrast induced nephropathy: meta-analysis of randomized, controlled trials
    Aaron M From
    Division of Cardiovascular Diseases, Mayo Clinic College of Medicine and Mayo Foundation Rochester, Minn, USA
    Circ Cardiovasc Interv 3:351-8. 2010
    Contrast-induced nephropathy (CIN) is associated with significant morbidity and mortality. The objective of our meta-analysis was to assess the efficacy of iodixanol compared with low-osmolar contrast media (LOCM) for prevention of CIN.
  22. ncbi Cardiovascular magnetic resonance measurement of myocardial extracellular volume in health and disease
    Daniel M Sado
    The Heart Hospital, 16 18 Westmoreland St, London W1G 8PH, UK
    Heart 98:1436-41. 2012
    ....
  23. ncbi The relative renal safety of iodixanol compared with low-osmolar contrast media: a meta-analysis of randomized controlled trials
    Michael Reed
    University of Michigan School of Medicine, VA Ann Arbor Healthcare System, University of Michigan, Ann Arbor, MI 48109 5853, USA
    JACC Cardiovasc Interv 2:645-54. 2009
    We sought to compare the nephrotoxicity of the iso-osmolar contrast medium, iodixanol, to low-osmolar contrast media (LOCM).
  24. ncbi Contrast-induced nephropathy after percutaneous coronary interventions in relation to chronic kidney disease and hemodynamic variables
    George Dangas
    Cardiovascular Research Foundation, Lenox Hill Heart and Vascular Institute, New York, New York, USA
    Am J Cardiol 95:13-9. 2005
    ..73 m(2)) and in 688 of 5,250 patients (13.1%) without CKD. Decreased eGFRs, periprocedural hypotension, higher contrast media volumes, lower baseline hematocrit, diabetes, pulmonary edema at presentation, intra-aortic balloon pump use, ..
  25. pmc Phase-sensitive inversion recovery for detecting myocardial infarction using gadolinium-delayed hyperenhancement
    Peter Kellman
    Laboratory of Cardiac Energetics, National Institutes of Health, National Heart, Lung and Blood Institute, Bethesda, Maryland 20892 1061, USA
    Magn Reson Med 47:372-83. 2002
    ..Phase-sensitive detection also has the advantage of decreasing the sensitivity to changes in tissue T(1) with increasing delay from contrast agent injection...
  26. ncbi Ferucarbotran (Resovist): a new clinically approved RES-specific contrast agent for contrast-enhanced MRI of the liver: properties, clinical development, and applications
    Peter Reimer
    Department of Radiology, Stadtisches Klinikum Karlsruhe, Moltkestrasse 90, 76133 Karlsruhe, Germany
    Eur Radiol 13:1266-76. 2003
    ....
  27. ncbi Cytotoxic effects of ionic high-osmolar, nonionic monomeric, and nonionic iso-osmolar dimeric iodinated contrast media on renal tubular cells in vitro
    Marc C Heinrich
    Department of Diagnostic Radiology, Division of Nephrology and Hypertension, University Hospital of Saarland, Homburg Saar, Germany
    Radiology 235:843-9. 2005
    To compare the cytotoxic effects of dimeric and monomeric iodinated contrast media on renal tubular cells in vitro with regard to osmolality.
  28. ncbi Reactive oxygen species and the pathogenesis of radiocontrast-induced nephropathy
    Samuel N Heyman
    Department of Medicine, Hadassah Hospital, Mt Scopus and the Hebrew University Medical School, Jerusalem, Israel
    Invest Radiol 45:188-95. 2010
    ..and the formation of reactive oxygen species (ROS) within the kidney following the administration of iodinated contrast media, which may play a role in the development of contrast media-induced nephropathy...
  29. pmc T1 mapping of the gadolinium-enhanced myocardium: adjustment for factors affecting interpatient comparison
    Neville Gai
    Radiology and Imaging Sciences, Clinical Center, and National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, Maryland 20892, USA
    Magn Reson Med 65:1407-15. 2011
    ..Examples of pre- and postcorrected values for a pool of normal subjects and in a patient cohort of type 1 diabetic patients shows tighter clustering and improved discrimination of disease state...
  30. pmc T1 mapping of the myocardium: intra-individual assessment of post-contrast T1 time evolution and extracellular volume fraction at 3T for Gd-DTPA and Gd-BOPTA
    Nadine Kawel
    Radiology and Imaging Sciences, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892 1074, USA
    J Cardiovasc Magn Reson 14:26. 2012
    ..The purpose of this study was to perform an intra-individual assessment of normal T1 time and ECV for two different contrast agents...
  31. ncbi Nephrotoxicity of iso-osmolar iodixanol compared with nonionic low-osmolar contrast media: meta-analysis of randomized controlled trials
    Marc C Heinrich
    Institute of Radiology, University Hospital of Erlangen, Maximiliansplatz 1, 91054 Erlangen, Germany
    Radiology 250:68-86. 2009
    To compare the nephrotoxicity of iso-osmolar iodixanol with that of nonionic low-osmolar contrast media (CM) (LOCM) in randomized clinical trials.
  32. ncbi Superparamagnetic iron oxide contrast agents: physicochemical characteristics and applications in MR imaging
    Y X Wang
    Department of Radiology, Erasmus University Medical Center-Dijkzigt, Dr. Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    Eur Radiol 11:2319-31. 2001
    ..Iron oxide particles for bowel contrast are coated with insoluble material, and all iron oxide particles for intravenous injection are biodegradable. Superparamagnetic agents open up an important field for research in MR imaging...
  33. ncbi Gold nanoparticles: a new X-ray contrast agent
    J F Hainfeld
    Nanoprobes, Inc, 95 Horse Block Road, Yaphank, NY 11980, USA
    Br J Radiol 79:248-53. 2006
    ..Gold nanoparticles can be used as X-ray contrast agents with properties that overcome some significant limitations of iodine-based agents...
  34. ncbi Human myocardium: single-breath-hold MR T1 mapping with high spatial resolution--reproducibility study
    Daniel R Messroghli
    BHF Cardiac MRI Unit, Leeds General Infirmary, England
    Radiology 238:1004-12. 2006
    ..This technique could enable direct quantification of changes in tissue characteristics in ischemic and inflammatory myocardial diseases...
  35. ncbi Strategies for increasing the sensitivity of gadolinium based MRI contrast agents
    Peter Caravan
    EPIX Pharmaceuticals, 67 Rogers St, Cambridge, MA 02142, USA
    Chem Soc Rev 35:512-23. 2006
    ..It may be of interest to senior undergraduates and more advanced researchers interested in lanthanide chemistry, biophysics, and/or molecular imaging...
  36. ncbi Noncontrast T1 mapping for the diagnosis of cardiac amyloidosis
    Theodoros D Karamitsos
    University of Oxford Centre for Clinical Magnetic Resonance Research, Department of Cardiovascular Medicine, John Radcliffe Hospital, Oxford, United Kingdom
    JACC Cardiovasc Imaging 6:488-97. 2013
    ..This study sought to explore the potential role of noncontrast myocardial T1 mapping for detection of cardiac involvement in patients with primary amyloid light-chain (AL) amyloidosis...
  37. pmc Diffuse myocardial fibrosis evaluation using cardiac magnetic resonance T1 mapping: sample size considerations for clinical trials
    Songtao Liu
    Radiology and Imaging Sciences, National Institutes of Health Clinical Center, Bethesda, MD, USA
    J Cardiovasc Magn Reson 14:90. 2012
    ..The aim of this study is to determine the reproducibility and sample size of CMR fibrosis measurements that would be applicable in clinical trials...
  38. ncbi Noninvasive detection of clinically occult lymph-node metastases in prostate cancer
    Mukesh G Harisinghani
    Massachusetts General Hospital and Harvard Medical School, Boston, USA
    N Engl J Med 348:2491-9. 2003
    ....
  39. ncbi Micellar nanocarriers: pharmaceutical perspectives
    V P Torchilin
    Department of Pharmaceutical Sciences and Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Mugar Building, Room 312, 360 Huntington Avenue, Boston, Massachusetts 02115, USA
    Pharm Res 24:1-16. 2007
    ..This review will discuss some recent trends in using micelles as pharmaceutical carriers...
  40. ncbi Evaluation of techniques for the quantification of myocardial scar of differing etiology using cardiac magnetic resonance
    Andrew S Flett
    Department of Cardiology, The Heart Hospital, University College London Hospitals NHS Trust, London, UK
    JACC Cardiovasc Imaging 4:150-6. 2011
    ....
  41. ncbi Using serum creatinine to estimate glomerular filtration rate: accuracy in good health and in chronic kidney disease
    Andrew D Rule
    Mayo Clinic, Rochester, Minnesota 55905, USA
    Ann Intern Med 141:929-37. 2004
    ..However, healthy persons were not included in the development of the MDRD equation...
  42. ncbi Glioma grading by using histogram analysis of blood volume heterogeneity from MR-derived cerebral blood volume maps
    Kyrre E Emblem
    Departments of Medical Physics, Rikshospitalet Radiumhospitalet Medical Centre, Sognsvannsveien 20, N 0027 Oslo, Norway
    Radiology 247:808-17. 2008
    ....
  43. pmc Quantification of diffuse myocardial fibrosis and its association with myocardial dysfunction in congenital heart disease
    Craig S Broberg
    Adult Congenital Heart Disease Program, Oregon Health and Science University, Portland, Ore, USA
    Circ Cardiovasc Imaging 3:727-34. 2010
    ..the etiology of ventricular dysfunction in adult congenital heart disease (ACHD) is not well understood. Diffuse fibrosis is a likely common final pathway and is quantifiable using MRI...
  44. ncbi Usefulness of diffusion-weighted MRI with echo-planar technique in the evaluation of cellularity in gliomas
    T Sugahara
    Department of Radiology, Kumamoto University School of Medicine, Japan
    J Magn Reson Imaging 9:53-60. 1999
    ..Diffusion-weighted MRI with EPI is a useful technique for assessing the tumor cellularity and grading of gliomas. This information is not obtained with conventional MRI and is useful for the diagnosis and characterization of gliomas...
  45. ncbi Acute Kidney Injury Network definition of contrast-induced nephropathy in the critically ill: incidence and outcome
    Karim Lakhal
    Service de Réanimation Médicale et Maladies Infectieuses, CHU Bichat Claude Bernard, Assistance Publique Hopitaux de Paris, F 75018 Paris, France
    J Crit Care 26:593-9. 2011
    ..We aimed to measure the incidence of CIN in a large ICU population using the Acute Kidney Injury Network (AKIN) definition and to investigate its impact on patients' outcome...
  46. ncbi Radiocontrast media cause dephosphorylation of Akt and downstream signaling targets in human renal proximal tubular cells
    Michele Andreucci
    Cattedra di Nefrologia, Universita Magna Graecia di Catanzaro, Viale Europa, loc Germaneto, Catanzaro, Italy
    Biochem Pharmacol 72:1334-42. 2006
    ..These results demonstrate the effect of RCM on some intracellular signaling pathways that may allow understanding of the mechanism of their toxicity and may allow the development of strategies to overcome their adverse effects...
  47. pmc Size, charge and concentration dependent uptake of iron oxide particles by non-phagocytic cells
    Daniel L J Thorek
    Department of Bioengineering, University of Pennsylvania, 210 South 33rd Street, 240 Skirkanich Hall, Philadelphia, PA 19104, USA
    Biomaterials 29:3583-90. 2008
    ..Our results show that an unconventional highly cationic particle configuration at 107nm maximized MR contrast of T cells, outperforming the widely utilized USPIO (<50nm)...
  48. pmc Development of a universal dual-bolus injection scheme for the quantitative assessment of myocardial perfusion cardiovascular magnetic resonance
    Masaki Ishida
    Division of Imaging Sciences, The Rayne Institute, London, UK
    J Cardiovasc Magn Reson 13:28. 2011
    ..As a solution to one of these problems, we have devised a universal dual-bolus injection scheme for use in a clinical setting. The purpose of this study is to show the setup and feasibility of the universal dual-bolus injection scheme...
  49. ncbi Microbubble-enhanced US in body imaging: what role?
    Stephanie R Wilson
    Department of Diagnostic Imaging, Foothills Medical Centre, University of Calgary, Calgary, AB, Canada
    Radiology 257:24-39. 2010
    ..Microbubble contrast agents are easy to use and robust; their use poses no risk of nephrotoxicity and requires no ionizing radiation. CE US plays a vital and expanding role that improves management and patient care...
  50. pmc Cardiac magnetic resonance imaging of myocardial contrast uptake and blood flow in patients affected with idiopathic or familial dilated cardiomyopathy
    Michael Jerosch-Herold
    Division of Cardiology, Department of Medicine, Oregon Health and Science University, Portland, Oregon, USA
    Am J Physiol Heart Circ Physiol 295:H1234-H1242. 2008
    ..56; P = 0.019). The expansion of the extracellular space correlated with reduced MBF and ventricular dilation. Expansion of the extracellular matrix may be a key contributor to contractile dysfunction in IDC patients...
  51. pmc Noninvasive monitoring of a murine model of metastatic pheochromocytoma: a comparison of contrast-enhanced microCT and nonenhanced MRI
    Lucia Martiniova
    Reproductive and Adult Endocrinology Program, National Institutes of Child Health and Human Development, Bethesda, Maryland 20892 1109, USA
    J Magn Reson Imaging 29:685-91. 2009
    ..However, the choice of imaging modality is still evolving...
  52. ncbi Local and reversible blood-brain barrier disruption by noninvasive focused ultrasound at frequencies suitable for trans-skull sonications
    Kullervo Hynynen
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Neuroimage 24:12-20. 2005
    ..The electron microscopy findings demonstrated HRP passage through vessel walls via both transendothelial and paraendothelial routes. These results demonstrate that completely noninvasive focal disruption of the BBB is possible...
  53. ncbi Lipid-based nanoparticles for contrast-enhanced MRI and molecular imaging
    Willem J M Mulder
    Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technology, P O Box 513, 5600 MB Eindhoven, The Netherlands
    NMR Biomed 19:142-64. 2006
    ..The mechanisms of particle formation, conjugation strategies and applications in the field of contrast-enhanced, cellular and molecular MRI are discussed...
  54. ncbi Ultrasound microbubble contrast agents: fundamentals and application to gene and drug delivery
    Katherine Ferrara
    Department of Biomedical Engineering, University of California, Davis, California 95616 8686, USA
    Annu Rev Biomed Eng 9:415-47. 2007
    ..The technology, early successes with drug and gene delivery, and potential clinical applications are reviewed...
  55. ncbi Characterization of the peri-infarct zone by contrast-enhanced cardiac magnetic resonance imaging is a powerful predictor of post-myocardial infarction mortality
    Andrew T Yan
    Cardiovascular Magnetic Resonance Imaging Program, Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, Boston, Massachusetts 02115, USA
    Circulation 114:32-9. 2006
    ..In this pilot study, we tested the hypothesis that the extent of the peri-infarct zone quantified by contrast-enhanced cardiac magnetic resonance (CMR) is an independent predictor of post-MI mortality...
  56. doi Guidelines and good clinical practice recommendations for contrast enhanced ultrasound (CEUS) - update 2008
    M Claudon
    Department of Radiology, Nancy, France
    Ultraschall Med 29:28-44. 2008
  57. ncbi Estimated radiation dose reduction using adaptive statistical iterative reconstruction in coronary CT angiography: the ERASIR study
    Jonathon Leipsic
    Department of Radiology and Department of Medicine, Division of Cardiology, University of British Columbia, Vancouver, BC, Canada
    AJR Am J Roentgenol 195:655-60. 2010
    ..The objective of our study was to assess the impact of Adaptive Statistical Iterative Reconstruction (ASIR) on radiation dose and study quality for coronary CT angiography (CTA)...
  58. ncbi Superparamagnetic iron oxide nanoparticle probes for molecular imaging
    Daniel L J Thorek
    Cellular and Molecular Imaging Group, Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, 19104, USA
    Ann Biomed Eng 34:23-38. 2006
    ..In this article, we attempt to illustrate the broad utility of SPIO in molecular imaging, including some of the recent developments, such as the transformation of SPIO into an activatable probe termed the magnetic relaxation switch...
  59. pmc In vivo MRI cell tracking: clinical studies
    Jeff W M Bulte
    Russell H Morgan Department of Radiology, Division of MR Research, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    AJR Am J Roentgenol 193:314-25. 2009
    ..The purpose of this review is to describe the principles of MRI cell tracking with superparamagnetic iron oxides and the four clinical trials that have been performed...
  60. ncbi Prevention of contrast media-associated nephropathy: randomized comparison of 2 hydration regimens in 1620 patients undergoing coronary angioplasty
    Christian Mueller
    Herz Zentrum, Bad Krozingen, Germany
    Arch Intern Med 162:329-36. 2002
    ..The administration of radiographic contrast agents remains an important cause of acute renal failure. The optimal infusion for hydration has not been evaluated...
  61. pmc Myocardial extravascular extracellular volume fraction measurement by gadolinium cardiovascular magnetic resonance in humans: slow infusion versus bolus
    Erik B Schelbert
    Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Cardiovasc Magn Reson 13:16. 2011
    ..Assuming equivalence between techniques, we further hypothesized that Ve measures would be reproducible across scans...
  62. ncbi Detection and characterization of focal liver lesions: a Japanese phase III, multicenter comparison between gadoxetic acid disodium-enhanced magnetic resonance imaging and contrast-enhanced computed tomography predominantly in patients with hepatocellular
    Tomoaki Ichikawa
    Department of Radiology, University of Yamanashi, School of Medicine, Yamanashi, Japan
    Invest Radiol 45:133-41. 2010
    ....
  63. ncbi Pathophysiology of renal tissue damage by iodinated contrast media
    Mauricio M Sendeski
    Institute of Vegetative Physiology, Charité Medical University, Berlin, Germany
    Clin Exp Pharmacol Physiol 38:292-9. 2011
    1. The present review focuses on the cytotoxic effects of iodinated contrast media (CM) that are shared by all types of CM. 2...
  64. pmc Myocardial T1 and extracellular volume fraction mapping at 3 tesla
    Jason J Lee
    Radiology and Imaging Sciences, National Institutes of Health Clinical Center, Bethesda, MD, USA
    J Cardiovasc Magn Reson 13:75. 2011
    ..To compare 11 heartbeat (HB) and 17 HB modified lock locker inversion recovery (MOLLI) pulse sequence at 3T and to establish preliminary reference values for myocardial T1 and the extracellular volume fraction (ECV)...
  65. ncbi The safety of Sonovue in abdominal applications: retrospective analysis of 23188 investigations
    Fabio Piscaglia
    Division of Internal Medicine, Department of Internal Medicine and Gastroenterology, University of Bologna, Bologna, Italy
    Ultrasound Med Biol 32:1369-75. 2006
    ....
  66. ncbi Cancer nanotechnology: opportunities and challenges
    Mauro Ferrari
    Division of Haematology and Oncology, 110U Davis Heart and Lung Research Institute, The Ohio State University, 473 West 12th Avenue, Columbus OH 43210 1002, USA
    Nat Rev Cancer 5:161-71. 2005
    ..These and other nanodevices can provide essential breakthroughs in the fight against cancer...
  67. ncbi Manganese-enhanced magnetic resonance imaging (MEMRI): methodological and practical considerations
    Afonso C Silva
    Laboratory of Functional and Molecular Imaging, National Institutes of Neurological Disorders and Stroke, Bethesda, MD 20892 1065, USA
    NMR Biomed 17:532-43. 2004
    ..In the present work the different approaches to MEMRI are reviewed from a practical standpoint. Emphasis is given to the experimental methodology of how to achieve significant, yet safe, amounts of Mn2+ to the target areas of interest...
  68. ncbi Hepatocellular carcinoma: hepatocyte-selective enhancement at gadoxetic acid-enhanced MR imaging--correlation with expression of sinusoidal and canalicular transporters and bile accumulation
    Takahiro Tsuboyama
    Department of Radiology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Radiology 255:824-33. 2010
    ..To investigate the mechanism of enhancement of hepatocellular carcinoma (HCC) on gadoxetic acid-enhanced hepatobiliary phase magnetic resonance (MR) images and to characterize HCC thus enhanced...
  69. ncbi Ultrasound microbubbles for molecular diagnosis, therapy, and theranostics
    Fabian Kiessling
    Department of Experimental Molecular Imaging, RWTH Aachen University, Aachen, Germany
    J Nucl Med 53:345-8. 2012
    ..This review on the use of microbubbles for ultrasound-based molecular imaging, therapy, and theranostics addresses innovative concepts and identifies areas in which clinical translation is foreseeable in the near future...
  70. ncbi Breast sentinel lymph node mapping at CT lymphography with iopamidol: preliminary experience
    Kazuyoshi Suga
    Department of Radiology, Yamaguchi University School of Medicine, 1 1 1 Minamikogushi, Ube, Yamaguchi 755 8505, Japan
    Radiology 230:543-52. 2004
    ..To evaluate sentinel lymph node (SLN) mapping with interstitial computed tomographic (CT) lymphography with small volumes of iopamidol for direction of SLN biopsy in breast cancer...
  71. ncbi SPIO-enhanced magnetic resonance imaging for the detection of metastases in sentinel nodes localized by computed tomography lymphography in patients with breast cancer
    Kazuyoshi Motomura
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    Ann Surg Oncol 18:3422-9. 2011
    ..The aim of this study was to evaluate MR imaging with superparamagnetic iron oxide (SPIO) enhancement for the detection of metastases in sentinel nodes localized by CT-LG in patients with breast cancer...
  72. pmc Assessment of molecular imaging of angiogenesis with three-dimensional ultrasonography
    Jason E Streeter
    Joint Department of Biomedical Engineering, University of North Carolina North Carolina State University, Chapel Hill, NC 27599, USA
    Mol Imaging 10:460-8. 2011
    ..3D MI, including volumetric analysis of inter- and intra-animal targeting, provides a thorough way of characterizing angiogenesis and will be a more robust assessment technique for the future of MI...
  73. pmc Effects of acoustic parameters and ultrasound contrast agent dose on focused-ultrasound induced blood-brain barrier disruption
    Nathan Mcdannold
    Department of Radiology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Ultrasound Med Biol 34:930-7. 2008
    ..This data suggests that over the range of parameters tested, BBB disruption is not affected by PRF or ultrasound contrast agent dose. However, both the BBB disruption magnitude and its threshold depend on the burst length...
  74. ncbi The histologic basis of late gadolinium enhancement cardiovascular magnetic resonance in hypertrophic cardiomyopathy
    James C C Moon
    Centre for Advanced Magnetic Resonance in Cardiology CAMRIC, London, United Kingdom
    J Am Coll Cardiol 43:2260-4. 2004
    ..We sought to identify the histologic basis of myocardial late gadolinium enhancement cardiovascular magnetic resonance (CMR) in hypertrophic cardiomyopathy (HCM)...
  75. ncbi Reversible blood-brain barrier disruption by repeated transcranial focused ultrasound allows enhanced extravasation
    Feng Yi Yang
    Department of Biomedical Imaging and Radiological Sciences, School of Biomedical Science and Engineering, National Yang Ming University, Taipei, Taiwan
    J Control Release 150:111-6. 2011
    ..This noninvasive technology offers the possibility of controlling the extent of drug delivery by means of repeated treatment and adjusting the duration and interval between sonications...
  76. ncbi Recent advances on surface engineering of magnetic iron oxide nanoparticles and their biomedical applications
    Ajay Kumar Gupta
    Laboratory for Nanoparticle Research, Formulation and Development Department, Torrent Research Centre, TPL, Village Bhat, Dist Gandhinagar 382 428, Gujarat, India
    Nanomedicine (Lond) 2:23-39. 2007
    ..We have reviewed the various biomedical applications with some of the most recent uses of magnetic nanoparticles for early detection of cancer, diabetes and atherosclerosis...
  77. pmc Blood-brain barrier disruption induced by focused ultrasound and circulating preformed microbubbles appears to be characterized by the mechanical index
    Nathan Mcdannold
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Ultrasound Med Biol 34:834-40. 2008
    ..It also suggests that lower frequency sonication produces less red blood cell extravasation per unit area...
  78. ncbi Quantitative evaluation of the use of microbubbles with transcranial focused ultrasound on blood-brain-barrier disruption
    Feng Yi Yang
    Institute of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, No 1, Section 1, Jen Ai Road, Taipei 100, Taiwan
    Ultrason Sonochem 15:636-43. 2008
    ..Our results indicate that injecting an appropriate quantity of UCA effectively increases and localizes the BBB disruption induced by transcranial FUS sonications...
  79. ncbi Effect of ultrasound contrast agent dose on the duration of focused-ultrasound-induced blood-brain barrier disruption
    Feng Yi Yang
    Department of Biomedical Imaging and Radiological Sciences, School of Biomedical Science and Engineering, National Yang Ming University, 11221 Taipei, Taiwan
    J Acoust Soc Am 126:3344-9. 2009
    ..This study demonstrates that the appropriate dose of UCA not only enhance the BBB opening but also effectively aid in controlling the duration of BBB disruption...
  80. ncbi Measurement of the gadopentetate dimeglumine partition coefficient in human myocardium in vivo: normal distribution and elevation in acute and chronic infarction
    S J Flacke
    Cardiovascular Division, Barnes-Jewish Hospital at Washington University Medical Center, St Louis, MO, USA
    Radiology 218:703-10. 2001
    ..CONCLUSION: Quantification of the lambda in vivo allows differentiation between normal and acutely or chronically infarcted myocardium, with high sensitivity and specificity...
  81. ncbi Accurate and objective infarct sizing by contrast-enhanced magnetic resonance imaging in a canine myocardial infarction model
    Luciano C Amado
    Department of Medicine, Division of Cardiology, Johns Hopkins University School of Medicine, 600 N Wolfe Street, Baltimore, MD 2187, USA
    J Am Coll Cardiol 44:2383-9. 2004
    ....
  82. pmc Clinical utility of cardiovascular magnetic resonance in hypertrophic cardiomyopathy
    Martin S Maron
    Hypertrophic Cardiomyopathy Center, Division of Cardiology, Tufts Medical Center, Boston, MA, USA
    J Cardiovasc Magn Reson 14:13. 2012
    ..These observations underscore an important role for CMR in the contemporary assessment of patients with HCM, providing important information impacting diagnosis and clinical management strategies...
  83. pmc Targeted magnetic iron oxide nanoparticles for tumor imaging and therapy
    Xiang Hong Peng
    Department of Medical Oncology Hematology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Int J Nanomedicine 3:311-21. 2008
    ..We review recent advances in the development of targeted IO nanoparticles for tumor imaging and therapy...
  84. ncbi Early changes in functional dynamic magnetic resonance imaging predict for pathologic response to neoadjuvant chemotherapy in primary breast cancer
    Mei Lin W Ah-See
    Mount Vernon Hospital, Northwood, Middlesex, UK
    Clin Cancer Res 14:6580-9. 2008
    ..We examined whether DCE-MRI done after two cycles of neoadjuvant chemotherapy could predict final clinical and pathologic response in primary breast cancers...
  85. ncbi Myocardial T1 mapping for detection of left ventricular myocardial fibrosis in chronic aortic regurgitation: pilot study
    Patrick Sparrow
    Department of Radiology, British Heart Foundation Cardiac MRI Unit, General Infirmary at Leeds, Great George St, Rm 170, D Fl, Jubilee Wing, Leeds LS1 3EX, UK
    AJR Am J Roentgenol 187:W630-5. 2006
    ....
  86. ncbi NGAL is an early predictive biomarker of contrast-induced nephropathy in children
    Russel Hirsch
    Division of Cardiology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Pediatr Nephrol 22:2089-95. 2007
    ..52, p < 0.0001) and plasma (R (2) = 0.72, p < 0.0001) were found to be powerful independent predictors of CIN. Patient demographics and contrast volume were not predictive of CIN...
  87. pmc A triple-targeted ultrasound contrast agent provides improved localization to tumor vasculature
    Jason M Warram
    University of Alabama at Birmingham, G082 Volker Hall, 1670 University Blvd, Birmingham, AL 35294 USA
    J Ultrasound Med 30:921-31. 2011
    ..This report summarizes an evaluation of multitargeted microbubbles, comparing single-, dual-, and triple-targeted motifs...
  88. pmc Ultrasound contrast microbubbles in imaging and therapy: physical principles and engineering
    Shengping Qin
    Department of Biomedical Engineering, University of California, 451 East Health Sciences Drive, Davis, CA 95616, USA
    Phys Med Biol 54:R27-57. 2009
    ..In this review, we focus on the physical aspects of these agents, exploring microbubble imaging modes, models for microbubble oscillation and the interaction of the microbubble with the endothelium...
  89. pmc Effect of microbubble size on fundamental mode high frequency ultrasound imaging in mice
    Shashank Sirsi
    Department of Chemical Engineering, Columbia University, New York, NY 10027, USA
    Ultrasound Med Biol 36:935-48. 2010
    ..The results of this study show that microbubbles can be tailored for optimal contrast enhancement in fundamental mode imaging...
  90. ncbi Antibiofouling polymer-coated gold nanoparticles as a contrast agent for in vivo X-ray computed tomography imaging
    Dongkyu Kim
    Research Center for Biomolecular Nanotechnology, Department of Life Science, Gwangju Institute of Science and Technology GIST, 1 Oryong dong, Buk Gu, Gwangju 500 712, Republic of Korea
    J Am Chem Soc 129:7661-5. 2007
    ..These results suggest that PEG-coated GNPs can be useful as a CT contrast agent for a blood pool and hepatoma imaging...
  91. pmc Detection and quantification of magnetically labeled cells by cellular MRI
    Wei Liu
    Philips Research North America, Briarcliff Manor, NY 10510, USA
    Eur J Radiol 70:258-64. 2009
    ..This review summarizes the practical issues regarding detection and quantification of magnetically labeled cells with various MRI contrast agents with a focus on SPIO nanoparticles...
  92. ncbi Incidence of immediate gadolinium contrast media reactions
    Martin R Prince
    Department of Radiology, Cornell and Columbia Universities, 416 East 55th Street, New York, NY 10022, USA
    AJR Am J Roentgenol 196:W138-43. 2011
    ..Our objective was to determine the incidence of immediate adverse events for gadolinium-based contrast agents...
  93. ncbi Magnetoliposomes with high USPIO entrapping efficiency, stability and magnetic properties
    Athanasios Skouras
    Laboratory of Pharmaceutical Technology, Dept of Pharmacy, School of Health Sciences, University of Patras, Patras, Greece
    Nanomedicine 7:572-9. 2011
    ..Targeted MLs retained their nanosize and integrity during storage for 1 month at 4 °C and up to 2 weeks at 37 °C...
  94. pmc Monitoring of implanted stem cell migration in vivo: a highly resolved in vivo magnetic resonance imaging investigation of experimental stroke in rat
    Mathias Hoehn
    Max Planck Institute for Neurological Research, Gleuelerstrasse 50, D 50931 Cologne, Germany Europe
    Proc Natl Acad Sci U S A 99:16267-72. 2002
    ..The imaging approach is ideally suited for the noninvasive observation of cell migration, engraftment, and morphological differentiation at high spatial and temporal resolution...
  95. ncbi Incidence of nephrogenic systemic fibrosis after adoption of restrictive gadolinium-based contrast agent guidelines
    Yingbing Wang
    Department of Radiology, Massachusetts General Hospital, 55 Fruit St, FND 213B, Boston, MA 02114, USA
    Radiology 260:105-11. 2011
    ..To retrospectively determine the incidence of nephrogenic systemic fibrosis (NSF) in a large academic medical center after the adoption of restrictive gadolinium-based contrast agent (GBCA) administration guidelines...
  96. pmc ECG quantification of myocardial scar in cardiomyopathy patients with or without conduction defects: correlation with cardiac magnetic resonance and arrhythmogenesis
    David G Strauss
    Division of Cardiology, Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Circ Arrhythm Electrophysiol 1:327-36. 2008
    ....
  97. ncbi 1H MR spectroscopy and diffusion-weighted imaging of the breast: are they useful tools for characterizing breast lesions before biopsy?
    Mitsuhiro Tozaki
    Division of Diagnostic Imaging, Breast Center, Kameda Medical Center, 929 Higashi Cho, Kamogawa, Chiba 296 8602, Japan
    AJR Am J Roentgenol 193:840-9. 2009
    ..The objective of our study was to determine whether proton ((1)H) MR spectroscopy (MRS) and diffusion-weighted imaging might be useful tools for characterizing breast lesions before biopsy...
  98. ncbi Diffusion-weighted MR imaging of the liver
    Bachir Taouli
    Department of Radiology, New York University Medical Center, New York, NY, USA
    Radiology 254:47-66. 2010
    ..Also, limitations, mainly image quality and reproducibility of diffusion parameters, and future directions of liver DW MR imaging will be discussed...
  99. ncbi FeCo/graphitic-shell nanocrystals as advanced magnetic-resonance-imaging and near-infrared agents
    Won Seok Seo
    Department of Chemistry and Laboratory for Advanced Materials, Stanford University, Stanford, California 94305, USA
    Nat Mater 5:971-6. 2006
    ..These results point to the potential of using these nanocrystals for integrated diagnosis and therapeutic (photothermal-ablation) applications...
  100. ncbi Late gadolinium enhancement of acute myocardial infarction in mice at 7T: cine-FLASH versus inversion recovery
    Andrea Protti
    Cardiovascular Division, King s College London British Heart Foundation Centre, London, United Kingdom
    J Magn Reson Imaging 32:878-86. 2010
    ..We therefore compared the IR technique against cine fast low shot angle (cine-FLASH) for the quantification of MI size in mice at 7T in vivo...
  101. ncbi Renal toxicity evaluation and comparison between visipaque (iodixanol) and hexabrix (ioxaglate) in patients with renal insufficiency undergoing coronary angiography: the RECOVER study: a randomized controlled trial
    Sang Ho Jo
    Division of Cardiology, Department of Internal Medicine, Seoul National University College of Medicine Cardiovascular Center, Seoul National University Hospital, Seoul, Korea
    J Am Coll Cardiol 48:924-30. 2006
    ..This study sought to compare the nephrotoxicity of iodixanol and ioxaglate in patients with renal impairment undergoing coronary angiography...

Research Grants63

  1. Novel PEG-Dendrimeric Contrast Agents for Cancer Imaging
    Yanjun Fu; Fiscal Year: 2006
    Primary goals of this program are to synthesize and develop new gadolinium (Gd)-based macromolecular contrast media (MMCM) for magnetic resonance imaging (MRI), with a novel combination and arrangement of constituents chosen to achieve ..
  2. Reliable Evaluation of Coronary Artery Disease using Myocardial BOLD MRI with CO2
    Rohan Dharmakumar; Fiscal Year: 2013
    ..addition to avoiding the risks of cardiac catheterization, it would be free of ionizing radiation, exogenous contrast media, and pharmacological stress-agents with both risks and side effects...
  3. Improved Drug Delivery to Tumors Using Novel Tissue Perfusion Approaches
    HEIKE ELIZABETH DALDRUP-LINK; Fiscal Year: 2012
    ..cancer responses after cytotoxic drug administration, we will demonstrate that MR imaging of macromolecular contrast media (MMCM) in the presence or absence of Alk5 blockade correlates with Doxil accumulation and thus can be used to ..
  4. Improved Classification of Acute Kidney Injury Following Iodinated Contrast Exam
    JENNIFER SENO MCDONALD; Fiscal Year: 2013
    ..to transition to an independent clinical researcher focused on optimizing imaging studies utilizing iodinated contrast media. This proposal outlines a five-year training plan at the Mayo Clinic under the primary mentorship of Dr...
  5. Risk Factors and Sequelae of Thyroid Disease in Patients with Renal Dysfunction
    CONNIE MEEYOUNG RHEE; Fiscal Year: 2012
    ..mechanistic link for this association, namely whether thyroid disease is promoted by exposure to iodinated contrast media in the setting of decreased renal excretory capacity...
  6. BOLD MRI: Application to Intra-renal Oxygenation
    Pottumarthi V Prasad; Fiscal Year: 2012
    ..that maintain oxygen sufficiency even under the threat of external stimuli such as during administration of contrast media. It is believed that compromise in the ability of the kidney to activate these control mechanisms during a "..
  7. Contrast-Enhanced Whole-Heart Coronary MRA at 3.0T
    Debiao Li; Fiscal Year: 2012
    ..Novel techniques will be designed to address these challenges. Clinically approved contrast media will be used to improve the visualization of coronary arteries...
  8. Quantitative DCEMRI of Prostate Cancer Correlation with Gold Standards
    Aytekin Oto; Fiscal Year: 2013
    ..We propose the following specific aims: 1. Quantitatively measure contrast media concentration, arterial input function, and physiological parameters (e.g...
  9. Stable, High Relaxivity MRI Contrast Agents
    PETER D CARAVAN; Fiscal Year: 2012
    ..New agents should demonstrate improved relaxivity from 1.5T to 7T and higher fields relative to existing contrast media. Second, new applications in molecular imaging require bifunctional molecules: a targeting group like a ..
  10. RADIOLOGIC ASPECTS OF CEREBROSPINAL FLUID ABSORPTION
    Daniel Gomez; Fiscal Year: 1990
    ..These studies will include observations of three sets of markers: 1) Radiologic water-soluble nonionic contrast media (iohexol and metrizamide); 2) labeled molecules (RISA and C14 sucrose) (to determine, by perfusion techniques, ..
  11. A Tumor-Specific Nanoimmunocomplex Markedly Improves MR Imaging
    Esther Chang; Fiscal Year: 2006
    ..In our preliminary work with this novel tumor targeting contrast media, we see very high tumor to background uptake in pancreatic carcinoma bearing animals (3 times that of standard ..
  12. Periodic Contrast-Enhanced CT With HYPR Reconstruction For Ablation Monitoring
    Christopher L Brace; Fiscal Year: 2013
    ..Specifically, we propose to: 1. Measure the uptake and transport of contrast media during thermal ablation Here we will measure the retention or expulsion of contrast media in normal liver and ..
  13. POLYMERIC MICELLAR CONTRAST AGENTS FOR CT ANGIOGRAPHY
    John Babich; Fiscal Year: 2000
    ..PROPOSED COMMERCIAL APPLICATIONS: Long-circulating micellar agents as contrast media for x-ray CT is potentially useful for diagnostic applications such as ischemic diseases (myocardial or ..
  14. Hyperpolarized MRI: Methods for Preparing Long-lived Hyperpolarized Contrast Age
    AARON GRANT; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Hyperpolarized liquid-phase contrast media can enhance the sensitivity of MRI by a factor of 10,000 or more...
  15. Digital Fluoroscopy for Cardiac Imaging
    Gerald Entine; Fiscal Year: 2005
    ..lesions near the edge of a high contrast object, a situation that occurs in cardiac studies with intravenous contrast media or when a vessel or lesion overlaps the edge of an overlying bone or a rib...
  16. Patient-Oriented Research in Kidney Disease
    Neil Powe; Fiscal Year: 2009
    ..racial disparities in occurrence of ESRD and a randomized clinical trial of low-versus highosmolality contrast media-induced nephrotoxicity);diagnosis (comparison of physical examination with color flow doppler for detection of ..
  17. THREE DIMENSIONAL TOMOGRAPHIC ANGIOGRAPHY
    Ruola Ning; Fiscal Year: 2000
    ..caliber, geometry and spatial orientation, while reducing the invasiveness of the procedure, the amount of contrast media required, procedure time and total X-ray exposure...
  18. New Approaches to Sampling and Analyzing Contrast Media
    Gillian Newstead; Fiscal Year: 2006
    ..We believe that this is in part because both the uptake and the washout of contrast media are often inadequately sampled, leading to errors in kinetic measurements as well as loss of morphologic ..
  19. BLOOD POOL CONTRAST AGENTS FOR CT AND MRI
    David Vera; Fiscal Year: 2003
    ..will be used to compare the CT and MR imaging properties of the new, optimized agent with those of standard contrast media. 2) Plasma half-time of one hour will be achieved by selection of dextran size and reporter density...
  20. BLOOD POOL CONTRAST AGENTS FOR CT AND MRI
    David Vera; Fiscal Year: 2002
    ..will be used to compare the CT and MR imaging properties of the new, optimized agent with those of standard contrast media. 2) Plasma half-time of one hour will be achieved by selection of dextran size and reporter density...
  21. PFCS FOR DIAGNOSTIC IMAGING
    Robert Mattrey; Fiscal Year: 1999
    ..harmonic imaging which can produce a tissue specific contrast enhancement compared to a background when no contrast media is present...
  22. FAST SPECTROSCOPIC MR IMAGING OF BREAST CANCER
    Gregory Karczmar; Fiscal Year: 2007
    ..analyzed to produce images proportional to water resonance linewidth, peak height, integral, changes following contrast media injection, and other parameters...
  23. MR IMAGING ADN SPECTROSCOPY OF ISCHEMIC HEART DISEASE
    Charles Higgins; Fiscal Year: 1990
    ..of reperfusion of a jeopardized region will be done using contrast enhanced MRI employing the paramagnetic contrast media, manganese polyphosphonate, while the status of the myocardium will be assessed by phosphorus 31 (31P) and ..
  24. Bolus Chasing CT Angiography Using Adaptive Control Techniques
    Ge Wang; Fiscal Year: 2007
    Intravenous injection of contrast media is required to enhance conspicuity of the vasculature, organs, lesions and tumors in CT, MR, and other imaging modal/ties...
  25. Bolus Chasing CT Angiography Using Adaptive Control
    Ge Wang; Fiscal Year: 2004
    Intravenous injection of contrast media is required to enhance conspicuity of the vasculature, organs, lesions and tumors in CT, MR, and other imaging modal/ties...
  26. Indirect Lymphosonography for Sentinel Node Localization
    Robert Mattrey; Fiscal Year: 2005
    ..San Diego and employs about 30 people all of whom were scientists or support staff at Alliance assigned to the contrast media effort...
  27. High-resolution tomography for small animal imaging
    CHARLES GARY; Fiscal Year: 2007
    ..can potentially be used to interrogate compartments which contain exogenously administered radiodense contrast media, or for microscopic non-invasive imaging such as genetic phenotyping in insects such as Drosophila ..
  28. DEVELOPMENT OF NEW RADIOGRAPHIC CONTRAST MEDIA
    Milos Sovak; Fiscal Year: 1980
    ..Large scale synthesis of the toxicologically preferred compounds will be developed. Synthesis of amino-erythritol will be developed and the new base incorporated into the analogs of the current compounds...
  29. COMPLEMENT, COAGULATION, IN CONTRAST MEDIA REACTIONS
    ELLIOTT LASSER; Fiscal Year: 1980
    ..We will also determine the direct protective effects, if any, of priming rabbits with human Cl-esterase inhibitor prior to contrast challenge...
  30. IMAGING MYOCARDIAL PERFUSION WITH NMR
    Robert Weisskoff; Fiscal Year: 1999
    ..novel MR imaging approaches to quantify changes in local myocardial perfusion without the use of exogenous MR contrast media. We propose theoretical models and experimental protocols to detect, characterize and exploit changes in the ..
  31. MONTE CARLO DOSIMETRY FOR INTRAVASCULAR BRACHYTHERAPY
    X Li; Fiscal Year: 2002
    ..issues, such as (i) source centering, (ii) the impacts in the presence of metallic stents, calcified plagues, contrast media and guide wires, and (iii) dosimetric comparison of various IVBT modalities, and to re- evaluate the dosimetry ..
  32. High Spectral/Spatial Resolution Imaging Breast Cancer
    Gregory Karczmar; Fiscal Year: 2006
    ..are analyzed to produce images proportional to resonance linewidth, peak height, integral, changes following contrast media injection, and other parameters...
  33. LIPOSOMAL CONTRAST AGENTS FOR MR IMAGING
    Evan Unger; Fiscal Year: 1991
    ..To overcome this problem, liposomal iodinated contrast media, which target to the reticuloendothelial system have also been used for CT and have resulted in improved ..
  34. Optimazed Quenched NIRF Probes for Optical Imaging
    Ronald Cook; Fiscal Year: 2004
    ..To enhance the quality of imaging, fluorescent bio-conjugates have been employed as "contrast media"...
  35. AUTOMATED GAS ENHANCED VASCULAR IMAGING
    Elvira Lang; Fiscal Year: 1999
    ..of gas as contrast medium has significant potential to avoid these recognized limitations of conventional contrast media solutions with high safety...
  36. Transducible Molecular Probes for Imaging Tumors
    Claude Sirlin; Fiscal Year: 2004
    ..Robert Mattrey, M.D., a successful clinical imaging scientist with expertise in contrast media and small animal imaging who is the principal investigator on a P20 grant aimed at developing an In Vivo ..
  37. A Single Injection Method of Determining In Vivo pH by MRI
    Garry Kiefer; Fiscal Year: 2007
    ..MRI contrast media are now widely used but the agents currently in clinical use are insensitive to biological information such as ..
  38. EFFECT OF X-RAY CONTRAST MEDIA ON CHROMOSOMES
    Amos Norman; Fiscal Year: 1980
    We have obtained evidence that the x-ray contrast media are responsible in large part for the chromosome damage observed in lymphocytes of patients after angiocardiography...
  39. DEVELOPMENT OF PARTICULATE RADIOCONTRAST MEDIA
    MICHAEL VIOLANTE; Fiscal Year: 1980
    ..The objective of this proposal is to design and synthesize new particulate contrast media; design of these new agents will be guided by the results of a thorough evaluation of a particulate contrast ..
  40. Microvessel Density With High Spectral/Spatial MRI
    Gregory Karczmar; Fiscal Year: 2009
    ..We will develop methods for acquiring and processing HiSS datasets to maximize sensitivity to contrast media and evaluate whether HiSS MRI accurately detects angiogenesis...
  41. Microvessel Density With High Spectral/Spatial MRI
    Gregory Karczmar; Fiscal Year: 2005
    ..We will develop methods for acquiring and processing HiSS datasets to maximize sensitivity to contrast media and evaluate whether HiSS MRI accurately detects angiogenesis...
  42. In-Vivo Imaging of Islet Transplantation
    Anna Moore; Fiscal Year: 2009
    ..MR imaging studies of islet transplantation on a pre-clinical model of human disease using FDA-approved contrast media suitable for labeling human islets...
  43. High-Spin Nitroxide Radical for Biomedical Imaging Applications
    Andrzej Rajca; Fiscal Year: 2009
    ..Contrast agents based on organic compounds with strong paramagnetic properties provide alternative MRI contrast media to the metal-based agents, avoiding the risk factors associated with the release of highly toxic metal ions...
  44. High-resolution tomography for small animal imaging
    CHARLES GARY; Fiscal Year: 2005
    ..can potentially be used to interrogate compartments which contain exogenously administered radiodense contrast media, or for microscopic non-invasive imaging such as genetic phenotyping in insects such as Drosophila ..
  45. ROTATIONAL ANGIOGRAPHIC DIGITAL IMAGING (ROAD)
    John Grady; Fiscal Year: 1991
    ..information on the spatial distribution of lesions and vasculature in real time with a single injection of contrast media. It is expected that this will replace many biplane applications, reduce radiation exposure to operators and ..
  46. VOLUME TOMOGRAPHIC ANGIOGRAPHY IMAGING (VTAI)
    John Grady; Fiscal Year: 1993
    ..The clinical significance of this technique is to simplify the procedure, and reduce the amount of injected contrast media, total x-ray dose and the procedure time, while supplying the angiographer with a direct, unambiguous and ..
  47. AUTOMATED IMAGE REGISTRATION FOR CLINICAL NEUROIMAGING
    VENKATESAN THANGARAJ; Fiscal Year: 1999
    ..and accuracy of the prototype on three specific medical indications for CT scanning (with and without contrast media.) The engineering prototype includes: a) software to receive and decode CT data, b)study-specific pre- and ..
  48. ULTRASONIC CONTRAST BLOOD FLOWMETRY
    K Shung; Fiscal Year: 1992
    ..on time domain blood flowmetry will be pursued in vitro in conjunction with the utilization of ultrasonic contrast media in a mock flow loop...
  49. Development of a Compact, Low-Cost Parahydrogen-Based Hyperpolarization System
    AARON GRANT; Fiscal Year: 2009
    ..The two main approaches to preparation of hyperpolarized contrast media are dynamic nuclear polarization (DNP) and parahydrogen-induced polarization (PHIP)...
  50. Dynamic Spatial and Spectral, Contrast Enhanced MRI of *
    Gregory Karczmar; Fiscal Year: 2006
    ..However, the spectral/spatial imaging approach has not previously been applied to dynamic imaging of contrast media uptake with high temporal resolution...
  51. IDENTIFICATION OF VASCULAR TARGETS FOR IN VIVO IMAGING
    Anthony Stevens; Fiscal Year: 2000
    ..Conventional water-soluble contrast media rapidly diffuses following injection, providing contrast for only a very short time...
  52. High Spectral & Spatial Resolution MRI of Rodent Tumors
    Gregory Karczmar; Fiscal Year: 2003
    ..b>Contrast media will be used to enhance contrast, improve depiction of tumor boundaries, and detect tumor vascular structure...
  53. VOLUMETRIC ANALYSIS OF THE AORTA AND ITS BRANCHES
    Geoffrey Rubin; Fiscal Year: 2002
    Modern helical CT technology, coupled with a rapid tntravenous infusion of iodinated contrast media, allows for the creation of volumetric angiograms...
  54. High Resolution In Vivo MicroCT Imaging and Analysis System for Rodents
    Douglas Adams; Fiscal Year: 2006
    ..will benefit greatly with the capability of high-resolution in vivo CT imaging and real-time perfusion of contrast media. Because ex vivo microCT imaging and morphometric analysis of excised tissue structures is nondestructive and ..
  55. Nano-carbon Compounds as High Contrast Agents for MRI
    JI ZHE LIU; Fiscal Year: 2003
    ..sought to develop new contrast materials with several orders of magnitude of higher resolutions than existing contrast media, such as Gd-DPTA...
  56. VIDEOROENTGENOGRAPHY IN CONGENITAL HEART DISEASE
    Thomas Graham; Fiscal Year: 1980
    ..sampling, without arterial cannulation, and potentially with only fluoroscopic radiation and small amounts of contrast media: ventricular and atrial volumes, ejection fraction, systemic blood flow, right and left pulmonary artery flow ..
  57. MR Guided Transendocardial Angiogenic Agents
    Maythem Saeed; Fiscal Year: 2007
    ..Improvements in MRI pulse sequence design and the use of recently developed MR contrast media will be pursued to evaluate the effects of angiogenic growth factors on ischemically injured myocardium...