Genomes and Genes
anti asthmatic agents
Summary: Drugs that are used to treat asthma.
Publications253 found, 100 shown here
- Worldwide severity and control of asthma in children and adults: the global asthma insights and reality surveysKlaus F Rabe
Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands
J Allergy Clin Immunol 114:40-7. 2004..In 1995, the Global Initiative for Asthma (GINA) guidelines recommended goals for the management of asthma, which were updated in 2002. However, there are no recent international surveys on the real management of asthma...
- Attitudes and actions of asthma patients on regular maintenance therapy: the INSPIRE studyMartyn R Partridge
Department of Respiratory Medicine, Faculty of Medicine, Imperial College London, London, UK
BMC Pulm Med 6:13. 2006....
- Measurement properties and interpretation of three shortened versions of the asthma control questionnaireElizabeth F Juniper
Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Canada
Respir Med 99:553-8. 2005..5. In conclusion, these three shortened versions of the ACQ can be used in large clinical trials without loss of validity or change in interpretation...
- Identifying 'well-controlled' and 'not well-controlled' asthma using the Asthma Control QuestionnaireElizabeth F Juniper
Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Canada
Respir Med 100:616-21. 2006....
- Shared treatment decision making improves adherence and outcomes in poorly controlled asthmaSandra R Wilson
Palo Alto Medical Foundation Research Institute, CA 94301, USA
Am J Respir Crit Care Med 181:566-77. 2010..Poor adherence to asthma controller medications results in poor treatment outcomes...
- Compliance, adherence, and concordance: implications for asthma treatmentRob Horne
Behavioural Medicine Research Unit, School of Pharmacy and Biomolecular Sciences, University of Brighton, Room 409, Watts Building, Lewes Rd, Brighton, BN2 4GJ, UK
Chest 130:65S-72S. 2006..This approach, based on a detailed examination of patients' perspectives on asthma and its treatment, and an open, nonjudgmental manner on the part of the clinician, is consistent with the idea of concordance...
- Evidence of remodeling in peripheral airways of patients with mild to moderate asthma: effect of hydrofluoroalkane-flunisolideCeline Bergeron
Meakins Christie Laboratories, McGill University, Montreal, Quebec, Canada
J Allergy Clin Immunol 116:983-9. 2005..It is not clear whether inflammation of the peripheral airways is associated with structural changes and whether this remodeling process can be modulated by deposition of inhaled corticosteroids (ICSs)...
- Dose-response relation of inhaled fluticasone propionate in adolescents and adults with asthma: meta-analysisS Holt
Wellington Asthma Research Group, Wellington School of Medicine, PO Box 7343, Wellington, New Zealand
BMJ 323:253-6. 2001..However, these findings were limited by the lack of data on individual patients and by the paucity of dose-response studies that included doses of >500 microg/day...
- Effect of obesity on clinical presentation and response to treatment in asthmaAnne E Dixon
University of Vermont, Burlington, VT 05401, USA
J Asthma 43:553-8. 2006..Obese and non-obese asthmatics have similar lung function abnormalities, but comorbidities and altered responses to medications may significantly affect asthma control in obese people...
- Suppression of cytokine expression by roflumilast and dexamethasone in a model of chronic asthmaC Herbert
Department of Pathology, School of Medical Sciences, University of New South Wales, Sydney, Australia
Clin Exp Allergy 38:847-56. 2008..In a mouse model of mild chronic asthma, both inflammation and remodelling can be suppressed by dexamethasone (a glucocorticoid) and roflumilast (a selective phosphodiesterase-4 inhibitor)...
- Are overweight asthmatics more difficult to control?P Saint-Pierre
Institut Universitaire de Recherche Clinique, Laboratoire de Biostatistique, Montpellier, France
Allergy 61:79-84. 2006..Because control of asthma clearly drives asthma management, this finding has consequences for defining original new strategies for managing asthma in overweight patients...
- New targets for drug development in asthmaIan M Adcock
Airways Disease Section, National Heart and Lung Institute, Imperial College London, London, UK
Lancet 372:1073-87. 2008..Although a cure is unlikely to be developed in the near future, a greater understanding of disease mechanisms could bring such a situation nearer to reality...
- Long-term comparison of 3 controller regimens for mild-moderate persistent childhood asthma: the Pediatric Asthma Controller TrialChristine A Sorkness
Clinical Science Center, University of Wisconsin, Madison, WI 53792, USA
J Allergy Clin Immunol 119:64-72. 2007..More evidence is needed on which to base recommendations for treatment of mild-moderate persistent asthma in school-aged children...
- Zafirlukast improves asthma control in patients receiving high-dose inhaled corticosteroidsJ C Virchow
Department of Pneumology, University Medical Clinic Freiburg, Germany and AstraZeneca Pharmaceuticals, Macclesfield, United Kingdom
Am J Respir Crit Care Med 162:578-85. 2000....
- The effect of treatment with omalizumab, an anti-IgE antibody, on asthma exacerbations and emergency medical visits in patients with severe persistent asthmaJ Bousquet
Hopital Arnaud de Villeneuve, Montpellier, France
Allergy 60:302-8. 2005..Such patients are at high risk of serious exacerbations and asthma-related mortality...
- Effects of mast cell membrane stabilizing agents in a rat lung ischemia-reperfusion modelK M Vural
Department of Cardiothoracic Surgery, College of Physicians and Surgeons, Columbia University, New York, New York, USA
Ann Thorac Surg 69:228-32. 2000....
- Identification of asthmatic children using prescription data and diagnosisGrete Moth
Danish Paediatric Asthma Centre, Aarhus University Hospital Skejby Sygehus, Aarhus N, Denmark
Eur J Clin Pharmacol 63:605-11. 2007..The aim of the study was to develop and validate a method for identifying asthmatic children between 6 and 14 years of age based on prescription data on anti-asthmatic drugs and diagnostic data...
- A meta-analysis of the dose-response relationship of inhaled corticosteroids in adolescents and adults with mild to moderate persistent asthmaJean Bousquet
Service des Maladies Respiratoires, Hopital Arnaud de Villeneuve, Centre Hospitalier Universitaire Montpellier, France
Clin Ther 24:1-20. 2002..Although inhaled corticosteroids (ICS) are commonly used in the treatment of persistent asthma, the relationship between dose and clinical response remains unclear...
- Particulate levels are associated with early asthma worsening in children with persistent diseaseNathan Rabinovitch
Division of Allergy and Immunology, Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
Am J Respir Crit Care Med 173:1098-105. 2006..Ambient particulate concentrations have been associated with variable physiologic effects in children with persistent asthma taking controller medications...
- Self-management of asthma in general practice, asthma control and quality of life: a randomised controlled trialB P A Thoonen
Department of General Practice Family Medicine, University Medical Centre Nijmegen, The Netherlands
Thorax 58:30-6. 2003..A study was undertaken to determine the effectiveness of asthma self-management in general practice...
- Adherence to asthma controller medication regimensD A Stempel
Department of Pediatrics, Infomed Northwest and University of Washington, Bellevue, WA 98004, USA
Respir Med 99:1263-7. 2005....
- The gap between evidence-based medicine and daily practice in the management of paediatric asthma. A pharmacy-based population study from The NetherlandsTjalling W de Vries
Department of Paediatrics, Medical Centre Leeuwarden, P O Box 888, 8901 BR, Leeuwarden, The Netherlands
Eur J Clin Pharmacol 62:51-5. 2006..We evaluated the adherence to national guidelines for the treatment of asthma in childhood...
- Effect of montelukast added to inhaled budesonide on control of mild to moderate asthmaM J Vaquerizo
Merck Sharp and Dohme, c Josefa Valcarcel 38, 28027 Madrid, Spain
Thorax 58:204-10. 2003..A 16 week multicentre, randomised, double blind, controlled study was undertaken to study the efficacy of adding oral montelukast, a leukotriene receptor antagonist, to a constant dose of inhaled budesonide...
- Inhaled corticosteroids: past lessons and future issuesDavid B Allen
Division of Endocrinology, University of Wisconsin Children s Hospital, Madison 53792 4108, USA
J Allergy Clin Immunol 112:S1-40. 2003....
- A new perspective on concepts of asthma severity and controlD R Taylor
Dunedin School of Medicine, University of Otago, PO Box 913, Dunedin, New Zealand
Eur Respir J 32:545-54. 2008..These markers can also act as surrogate measures for future risk...
- Asthma exacerbations and sputum eosinophil counts: a randomised controlled trialRuth H Green
Institute for Lung Health, Department of Respiratory Medicine and Thoracic Surgery, Glenfield Hospital, LE3 9PQ, Leicester, UK
Lancet 360:1715-21. 2002..We aimed to assess whether a management strategy that minimises eosinophilic inflammation reduces asthma exacerbations compared with a standard management strategy...
- The use of anti-asthmatic medications among pediatric patients in TaiwanChi Yu Chen
Graduate Institute of Pharmaceutical Sciences, Kaohsiung Medical University, 100 Shih Chuan 1st Road, Kaohsiung 80708, Taiwan
Pharmacoepidemiol Drug Saf 12:129-33. 2003..To describe the use of anti-asthma drugs in Taiwanese pediatric patients...
- Effect of montelukast on lung function in asthma patients with allergic rhinitis: analysis from the COMPACT trialD B Price
Department of General Practice and Primary Care, University of Aberdeen, Foresterhill Health Centre, Aberdeen UK
Allergy 61:737-42. 2006..This analysis was designed to examine whether asthmatic patients with comorbid AR respond differently than patients without comorbid AR in terms of asthma control (lung function)...
- Transient receptor potential and other ion channels as pharmaceutical targets in airway smooth muscle cellsHwei L Ong
Department of Medical Biochemistry, School of Medicine, Flinders University, Adelaide, South Australia, Australia
Respirology 9:448-57. 2004....
- Systemic effects of inhaled fluticasone propionate and budesonide in adult patients with asthmaE Derom
Department of Respiratory Diseases, University Hospital of Ghent, Ghent, Belgium
Am J Respir Crit Care Med 160:157-61. 1999..We conclude that high doses of BUD and FP (in particular the latter), inhaled via their respective dry powder inhalers for 1 wk, result in a measurable systemic activity in patients with asthma...
- Second-line controller therapy for persistent asthma uncontrolled on inhaled corticosteroids: the step 3 dilemmaBrian J Lipworth
Department of Clinical Pharmacology and Therapeutics, Asthma and Allergy Research Group, Ninewells University Hospital and Medical School, University of Dundee, Dundee, Scotland, UK
Drugs 62:2315-32. 2002..For the patient whose lung function is less impaired, with evidence of ongoing BHR where bronchoprotection is needed (e.g. exercise, allergen, cold air), or when there is concomitant allergic rhinitis, then an LTA would be more suitable...
- Inhaler devices in infants and children: challenges and solutionsMark L Everard
Department of Respiratory Medicine, Sheffield Children s Hospital, Sheffield, United Kingdom
J Aerosol Med 17:186-95. 2004
- Pretreatment of cromolyn sodium prior to reperfusion attenuates early reperfusion injury after the small intestine ischemia in ratsZi Qing Hei
Department of Anesthesiology, The Third Affiliated Hospital, Sun Yat Sen University, Guangzhou 510630, Guangdong Province, China
World J Gastroenterol 13:5139-46. 2007..To investigate the effects of Cromolyn Sodium (CS) pretreated prior to reperfusion on the activity of intestinal mucosal mast cells (IMMC) and mucous membrane of the small intestine in ischemia-reperfusion (IR) injury of rats...
- Therapeutic ratio of inhaled corticosteroids in adult asthma. A dose-range comparison between fluticasone propionate and budesonide, measuring their effect on bronchial hyperresponsiveness and adrenal cortex functionL P Nielsen
Department of Respiratory Diseases, Aarhus University Hospital, Aarhus, Denmark
Am J Respir Crit Care Med 162:2053-7. 2000..Therapeutic ratio over a wide dose range, determined by impact on bronchial responsiveness and endogenous corticosteroid production, seems to favor FP...
- Can guideline-defined asthma control be achieved? The Gaining Optimal Asthma ControL studyEric D Bateman
UCT Lung Institute, P O Box 34560, Groote Schuur 7937, Cape Town, South Africa
Am J Respir Crit Care Med 170:836-44. 2004..07-0.27 per patient per year) and improvement in health status were significantly better with salmeterol/fluticasone. This study confirms that the goal of guideline-derived asthma control was achieved in a majority of the patients...
- Addition of montelukast or salmeterol to fluticasone for protection against asthma attacks: a randomized, double-blind, multicenter studyJonathan Ilowite
Winthrop University Hospital, Pulmonary and Critical Care Division, Mineola, New York 11501, USA
Ann Allergy Asthma Immunol 92:641-8. 2004..For patients whose asthma is uncontrolled with low-dose inhaled corticosteroids, addition of alternative therapy instead of increasing the steroid dose is recommended by current treatment guidelines...
- Anti-leukotrienes as add-on therapy to inhaled glucocorticoids in patients with asthma: systematic review of current evidenceFrancine M Ducharme
Department of Paediatrics, McGill University Health Centre, Montreal, QC H3H 1P3, Canada
BMJ 324:1545. 2002..To examine the evidence for the efficacy and glucocorticoid sparing effect of oral anti-leukotrienes taken daily as add-on therapy to inhaled glucocorticoids in patients with asthma...
- Severe asthma: an overviewWendy C Moore
Center for Human Genomics, and Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
J Allergy Clin Immunol 117:487-94; quiz 495. 2006..Treatment algorithms based on markers of airway inflammation may decrease measures of health care utilization in severe asthma...
- Improvement of aspirin-intolerant asthma by montelukast, a leukotriene antagonist: a randomized, double-blind, placebo-controlled trialSven Erik Dahlen
Experimental Asthma and Allergy Research, The National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
Am J Respir Crit Care Med 165:9-14. 2002..Addition of a leukotriene receptor antagonist such as montelukast improves asthma in aspirin-intolerant patients over and above what can be achieved by glucocorticosteroids...
- Significant variability in response to inhaled corticosteroids for persistent asthmaStanley J Szefler
National Jewish Medical and Research Center, Department of Pediatrics, Denver, CO 80206, USA
J Allergy Clin Immunol 109:410-8. 2002..A clinical model is needed to compare inhaled corticosteroids (ICSs) with respect to efficacy...
- Inadequate use of asthma medication in the United States: results of the asthma in America national population surveyRobert J Adams
Department of Medicine, University of Adelaide, The Queen Elizabeth Hospital Campus, Woodville, Australia
J Allergy Clin Immunol 110:58-64. 2002..Studies of the use of anti-inflammatory asthma therapy have been limited to selected populations or have been unable to assess the appropriateness of therapy for individuals...
- Allergic rhinitis: a potential cause of increased asthma medication use, costs, and morbidityMichael T Halpern
Exponent Inc, Alexandria, Virginia, USA
J Asthma 41:117-26. 2004..Physicians should assess asthma patients for symptoms of allergic rhinitis to improve asthma treatment...
- Montelukast and fluticasone compared with salmeterol and fluticasone in protecting against asthma exacerbation in adults: one year, double blind, randomised, comparative trialLeif Bjermer
Department of Respiratory Medicine and Allergology, University Hospital, SE 221 85 Lund, Sweden
BMJ 327:891. 2003..Design and setting A 52 week, two period, double blind, multicentre trial during which patients whose symptoms remained uncontrolled by inhaled corticosteroids were randomised to add montelukast or salmeterol...
- [Cost and management of asthma exacerbations in Spanish hospitals (COAX study in hospital services)]L Borderias Clau
Servicio de Neumologia, Hospital San Jorge, Huesca, Spain
Arch Bronconeumol 41:313-21. 2005..The study formed part of a broader study (COAX II), with the same objectives in each of the 8 participating European countries...
- Exhaled NO and assessment of anti-inflammatory effects of inhaled steroid: dose-response relationshipS L Jones
Dept of Medical and Surgical Sciences, Dunedin School of Medicine, University of Otago, New Zealand
Eur Respir J 20:601-8. 2002..The relationship found in this study was linear over the dose range 0-500 microg x day(-1) soon after commencing therapy and continued over time...
- Do regular check ups and preventive drug use reduce asthma severity in school children?Lyle J Palmer
Schools of Medicine, Pharmacology and Population Health, University of Western Australia
Aust Fam Physician 33:573-6. 2004..To investigate whether regular check ups and preventive drug use reduce asthma symptoms in school children...
- Randomised controlled trial of montelukast plus inhaled budesonide versus double dose inhaled budesonide in adult patients with asthmaD B Price
Department of General Practice and Primary Care, University of Aberdeen, Foresterhill Health Centre, Westburn Road, Aberdeen AB25 2AY, Scotland, UK
Thorax 58:211-6. 2003..This double blind, randomised, parallel group, non-inferiority, multicentre 16 week study compared the clinical benefits of adding montelukast to budesonide with doubling the budesonide dose in adults with asthma...
- [Asthma epidemiology]Isabella Annesi-Maesano
Epidémiologie des Maladies Allergiques et Respiratoires, INSERM U472 Epidémiologie et Biostatistique, 16, avenue Paul Vaillant Couturier, 94807 Villejuif
Rev Prat 55:1295-8. 2005..Gene-environment interactions already in early life should be explored to understand asthma epidemiological evolution...
- Glycyrrhizin alleviates experimental allergic asthma in miceArjun Ram
Molecular Immunogenetics Laboratory, Institute of Genomics and Integrative Biology, Mall Road, Delhi 110007, India
Int Immunopharmacol 6:1468-77. 2006..We have also showed that it has no effect on serum cortisol levels. Our results demonstrate that GRZ alleviates asthmatic features in mice and it could be useful towards developing a better therapeutic molecule in the future...
- Fluticasone propionate nasal spray is superior to montelukast for allergic rhinitis while neither affects overall asthma controlRobert A Nathan
Asthma and Allergy Associates, P C, 2709 North Tejon St, Colorado Springs, CO 80907, USA
Chest 128:1910-20. 2005..Asthma and allergic rhinitis are both highly prevalent diseases and often coexist in patients...
- Inappropriate use of anti-asthmatic drugs in the Italian paediatric populationAntonio Clavenna
Laboratory for Mother and Child Health, Mario Negri Institute for Pharmacological Research, Milan, Italy
Eur J Clin Pharmacol 59:565-9. 2003..To evaluate anti-asthmatic drug prescriptions in a large Italian paediatric population...
- Population pharmacokinetics and pharmacodynamics of ciclesonideS Rohatagi
Aventis Pharmaceuticals Mail Stop BWM 203F, Route 202 206, P O Box 6800, Bridgewater, NJ 08807 0800, USA
J Clin Pharmacol 43:365-78. 2003..The disposition and effect of CIC-AP can be described using mixed-effect modeling. The estimated EC50 is similar to mean Cmax from an 800-micrograms dose, further suggesting CIC-AP has little effect on cortisol suppression...
- Healthcare and workloss costs associated with patients with persistent asthma in a privately insured populationG Colice
Washington Hospital Center, Washington, DC, USA
J Occup Environ Med 48:794-802. 2006..The objective of this study was to estimate annual healthcare and workloss costs of patients with persistent asthma by severity...
- Allergic rhinitis: evidence for impact on asthmaMike Thomas
Department of General Practice and Primary Care, University of Aberdeen, Foresterhill Health Centre, Westburn Road, Aberdeen AB25 2AY, UK
BMC Pulm Med 6:S4. 2006..This paper reviews the current evidence indicating that comorbid allergic rhinitis may have clinically relevant effects on asthma...
- Asthma control in patients with asthma and allergic rhinitis receiving add-on montelukast therapy for 12 months: a retrospective observational studyLuis Borderias
Pneumology Department, San Jorge Hospital, Huesca, Spain
Curr Med Res Opin 23:721-30. 2007..No studies to date have examined whether montelukast can improve asthma control over a long period of time in patients with seasonal AR and asthma...
- Understanding the pathogenesis of allergic asthma using mouse modelsK P Leong
Department of Rheumatology and Immunology, Tan Tock Seng Hospital, Singapore
Ann Allergy Asthma Immunol 87:96-109; quiz 110,. 2001..The reader will also encounter new treatment strategies that have arisen as this knowledge is applied in practice...
- Response of preschool children with asthma symptoms to fluticasone propionateR J Roorda
Department of Pediatrics, Isala Klinieken, De Weezenlanden Hospital, Zwolle, The Netherlands
J Allergy Clin Immunol 108:540-6. 2001..These findings may help to predict treatment outcome and guide the management of preschool children with recurrent asthma symptoms...
- Low-dose inhaled corticosteroids and the prevention of death from asthmaS Suissa
Division of Clinical Epidemiology, Royal Victoria Hospital, McGill University Health Centre, Montreal, QC, Canada
N Engl J Med 343:332-6. 2000..Although inhaled corticosteroids are effective for the treatment of asthma, it is uncertain whether their use can prevent death from asthma...
- Budesonide/formoterol for maintenance and relief in uncontrolled asthma vs. high-dose salmeterol/fluticasoneJean Bousquet
Hopital Arnaud de Villeneuve, 371 Avenue Doyen Gaston Giraud, FR 34000 Montpellier, France
Respir Med 101:2437-46. 2007....
- Pharmacokinetics and anti-asthmatic potential of non-parenterally administered recombinant human interleukin-1 receptor antagonist in animal modelsTing Li
State Key Laboratory of Natural and Biomimetic Drugs and School of Pharmaceutical Sciences, Peking University, Beijing, China
J Pharmacol Sci 102:321-30. 2006....
- Addition of salmeterol to low-dose fluticasone versus higher-dose fluticasone: an analysis of asthma exacerbationsJ Matz
Atlantic Asthma and Allergy Center, Inc, Baltimore, MD, USA
J Allergy Clin Immunol 107:783-9. 2001..The ability to detect deteriorating asthma and the severity of exacerbation was similar between groups...
- Anti-asthmatic drugs and dosage forms in children: a cross-sectional studyEric Schirm
Department of Social Pharmacy and Pharmacoepidemiology, Groningen University Institute for Drug Exploration GUIDE, Groningen, The Netherlands
Pharm World Sci 24:162-5. 2002..To describe the choice of drugs as well as the dosage forms of anti-asthmatic drugs in children with regard to different age groups...
- Effect of inhaled ciclesonide on airway responsiveness to inhaled AMP, the composition of induced sputum and exhaled nitric oxide in patients with mild asthmaF Kanniess
Pulmonary Research Institute, Hospital Grosshansdorf, Grosshansdorf, D 22927, Germany
Pulm Pharmacol Ther 14:141-7. 2001..These data suggest that ciclesonide is equi-effective to budesonide with regard to its potency to reduce the airway responsiveness to inhaled AMP as well as airway inflammation in patients with mild asthma...
- Treatment of chronic rhinosinusitis and its effects on asthmaS Ragab
Tanta University Hospitals, Tanta, Egypt
Eur Respir J 28:68-74. 2006..Treatment of chronic rhinosinusitis, medical or surgical, benefits concomitant asthma; that associated with nasal polyposis benefits more from medical therapy...
- Systemic adverse effects of inhaled corticosteroid therapy: A systematic review and meta-analysisB J Lipworth
Department of Clinical Pharmacology and Therapeutics and Respiratory Medicine, Ninewells Hospital and Medical School, University of Dundee, Scotland
Arch Intern Med 159:941-55. 1999..To appraise the data on systemic adverse effects of inhaled corticosteroids...
- Circadian rhythm of serum cortisol after repeated inhalation of the new topical steroid ciclesonideAnita Weinbrenner
Department of Clinical Pharmacology, Ernst Moritz Arndt University, Greifswald 17487, Germany
J Clin Endocrinol Metab 87:2160-3. 2002....
- Self-reported adherence in patients with asthmaBrian D De Smet
Department of Pharmacy Services, University of Michigan Hospitals and Health Centers, Ann Arbor, 48109, USA
Ann Pharmacother 40:414-20. 2006..The Behavioral Model of Health Services Utilization, organized as predisposing, enabling, and need variables, may be useful in identifying variables related to adherent medication-taking behavior...
- Use of anti-asthmatic medications as a proxy for prevalence of asthma in children and adolescents in Norway: a nationwide prescription database analysisKari Furu
Department of Pharmacoepidemiology, Division of Epidemiology, Norwegian Institute of Public Health, PO Box 4404, Nydalen, 0403 Oslo, Norway
Eur J Clin Pharmacol 63:693-8. 2007..The aim of this study was to assess the prevalence of dispensed anti-asthmatic medications as a proxy of asthma among children and adolescents aged 0-19 years in Norway...
- Bronchial thermoplasty for asthmaGerard Cox
M B, Firestone Institute for Respiratory Health T2123, St Joseph s Healthcare, 50 Charlton Avenue, East Hamilton, ON L8N 4A6, Canada
Am J Respir Crit Care Med 173:965-9. 2006..Bronchial thermoplasty (BT) reduces the potential for smooth muscle-mediated bronchoconstriction by reducing the mass of smooth muscle in the walls of conducting airways...
- Costs of asthma treatment in EstoniaR A Kiivet
University of Tartu, Department of Public Health, Ravila 19, EE 50411, Tartu, Estonia
Eur J Public Health 11:89-92. 2001..The total estimated direct costs of asthma diagnosis and treatment during 1997, as extrapolated from the study population, were 2.1 million EUR, and accounted for 1.4% of direct health care costs in Estonia...
- Association of low-level ozone and fine particles with respiratory symptoms in children with asthmaJanneane F Gent
Center for Perinatal, Pediatric, and Environmental Epidemiology, Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Conn 06510, USA
JAMA 290:1859-67. 2003..Exposure to ozone and particulate matter of 2.5 microm or less (PM2.5) in air at levels above current US Environmental Protection Agency (EPA) standards is a risk factor for respiratory symptoms in children with asthma...
- [Cost-of-illness of asthma in Denmark in the year 2000]Robert Mossing
Afdeling for Epidemiologi, Arbejdsmiljøinstituttet, Lersø Parkallé 105, DK 2100 København
Ugeskr Laeger 165:2646-9. 2003..The total number of asthmatic patients in Denmark in the year 2000 was about 300,000 out of a total population of 5.3 million. The aim of this study was to evaluate cost-of-illness for all asthma patients in Denmark for the year 2000...
- Cost, morbidity, and control of asthma in Hungary: The Hunair StudyIren Herjavecz
National Koranyi Institute of TBC and Pulmonology, Budapest, Hungary
J Asthma 40:673-81. 2003..To assess asthma-related morbidity, symptom control, and societal cost of asthmatic patients in Hungary. Secondary objective was to assess the relationship between asthma symptom control and costs incurred...
- Clinical equivalence of salmeterol/fluticasone propionate in combination (50/100 microg twice daily) when administered via a chlorofluorocarbon-free metered dose inhaler or dry powder inhaler to patients with mild-to-moderate asthmaE D Bateman
UCT Lung Institute, Groote Schuur, Cape Town, South Africa
Respir Med 95:136-46. 2001..Patients switching to SALM/FP from other MDI-based asthma treatments may now do so without a change of delivery device...
- Comparison of the systemic effects of fluticasone propionate and budesonide given by dry powder inhaler in healthy and asthmatic subjectsT W Harrison
Division of Respiratory Medicine, Nottingham City Hospital, Nottingham NG5 1PB, UK
Thorax 56:186-91. 2001....
- Azithromycin reduces bronchial hyperresponsiveness and neutrophilic airway inflammation in asthmatic children: a preliminary reportGiorgio L Piacentini
Department of Pediatrics, University of Verona, Verona, Italy
Allergy Asthma Proc 28:194-8. 2007..2 +/- 4.2% at baseline and 3.3 +/- 3.6% at the end of the study. A short course of azithromycin is associated with amelioration of BHR and reduction in airway neutrophil infiltration in some children with asthma...
- Short-acting beta 2-agonist and oral corticosteroid use in asthma patients prescribed either concurrent beclomethasone and long-acting beta 2-agonist or salmeterol/fluticasone propionate combinationR Angus
Aintree Chest Centre, Liverpool L9 7AL, UK
Int J Clin Pract 59:156-62. 2005..In clinical practice, adding LABA to IC therapy by using a combination inhaler produces significantly better asthma control than administering the drugs in separate inhalers...
- Increased risk of asthma attacks and emergency visits among asthma patients with allergic rhinitis: a subgroup analysis of the investigation of montelukast as a partner agent for complementary therapy [corrected]J Bousquet
Service des Maladies Respiratoires, Hopital Arnaud de Villeneuve, Montpellier, Cedex 5, France
Clin Exp Allergy 35:723-7. 2005..We assessed asthma-related medical resource use and attacks in asthmatic patients who did and did not have concomitant AR and were adding montelukast or salmeterol to baseline treatment with inhaled fluticasone...
- Childhood asthmaN M Clark
University of Michigan School of Public Health Department of Health, Behavior and Health Education, Ann Arbor 48109 2029, USA
Environ Health Perspect 107:421-9. 1999....
- Has asthma medication use in children become more frequent, more appropriate, or both?D C Goodman
Center for the Evaluative Clinical Sciences, Department of Community and Family Medicine, University of Washington, Seattle, USA
Pediatrics 104:187-94. 1999..This study measures trends and recent patterns in the pediatric use of medications approved for reversible obstructive airway disease (asthma medications)...
- Effectiveness of pharmacotherapy in asthmatic preschool childrenJ C de Jongste
Department of Pediatrics, Division Pediatric Respiratory Medicine, Erasmus University and University Hospital Sophia Children s Hospital, Rotterdam, The Netherlands
Allergy 57:42-7. 2002..Also, we need methods to separate the different phenotypes within the group of recurrently wheezing preschool children to optimize targeting of asthma treatment to those who have ongoing airway inflammation...
- A single inhaler for asthma?Peter J Barnes
Am J Respir Crit Care Med 171:95-6. 2005
- Asthma treatment preference study: a conjoint analysis of preferred drug treatmentsGunnar Johansson
Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden
Chest 125:916-23. 2004..Assessment of patient preferences for attributes of asthma treatments...
- A Danish population-based cohort study of newly diagnosed asthmatic children's care pathway - adherence to guidelinesGrete Moth
Danish Paediatric Asthma Centre, Aarhus University Hospital, Skejby, Denmark
BMC Health Serv Res 8:130. 2008..The aim of the study was to analyse associations between care providers and adherence to guidelines concerning frequency of contacts with the health service due to asthma...
- Improved refill persistence with fluticasone propionate and salmeterol in a single inhaler compared with other controller therapiesStuart W Stoloff
University of Nevada School of Medicine, Reno, Nev, USA
J Allergy Clin Immunol 113:245-51. 2004..Improved adherence to inhaled corticosteroids (ICSs) has also been associated with decreased asthma-associated morbidity and mortality...
- Design and baseline characteristics of the epidemiology and natural history of asthma: Outcomes and Treatment Regimens (TENOR) study: a large cohort of patients with severe or difficult-to-treat asthmaChantal M Dolan
Genentech Inc, South San Francisco, California 94080, USA
Ann Allergy Asthma Immunol 92:32-9. 2004..The goal of The Epidemiology and Natural History of Asthma: Outcomes and Treatment Regimens (TENOR) study is to better understand the natural history of asthma in these patients...
- Twelve-month safety and efficacy of inhaled fluticasone propionate in children aged 1 to 3 years with recurrent wheezingHans Bisgaard
Department of Pediatrics, Copenhagen University Hospital, Copenhagen, Denmark
Pediatrics 113:e87-94. 2004..Our aim was to compare the 12-month safety and efficacy of fluticasone propionate (FP) and sodium cromoglycate (SCG) in children aged 1 to 3 years with mild to moderate recurrent wheeze...
- Development of the satisfaction with inhaled asthma treatment questionnaireJ L Campbell
Peninsula Medical School, Exeter, UK
Eur Respir J 22:127-34. 2003..The Satisfaction with Asthma Treatment Questionnaire is potentially a useful instrument for gaining insight into patient satisfaction with inhaled treatment for asthma...
- Inhaled corticosteroids reduce bone mineral density in early postmenopausal but not premenopausal asthmatic womenK Fujita
University of Shiga Prefecture, Hikone, Japan
J Bone Miner Res 16:782-7. 2001..Ovarian hormones may be protective against the adverse effect of inhaled BDP on bone metabolism in the premenopausal patients...
- Does your child have asthma? Filled prescriptions and household report of child asthmaJutta M Joesch
Battelle Centers for Public Health Research and Evaluation, Seattle, Washington 98109 3598, USA
J Pediatr Health Care 20:374-83. 2006..Confidence is examined in the report of asthma for children, obtained in a survey from the adult household member most knowledgeable about household health care (MKA)...
- The role of long-acting beta-agonists in the management of asthma: analysis, meta-analysis, and more analysisJeffrey Glassroth
Ann Intern Med 144:936-7. 2006
- The economic impact of children dispensed asthma medications without an asthma diagnosisDavid A Stempel
Infomed Northwest Bellevue and University of Washington, Bellevue, Washington 98004, USA
J Pediatr 148:819-23. 2006..To compare the resource utilization and healthcare costs of children with a diagnosis of asthma, children dispensed asthma medications but without a diagnosis of asthma, and control children...
- Impact of montelukast on symptoms in mild-to-moderate persistent asthma and exercise-induced asthma: results of the ASTHMA survey. Adding Singulair Treatment to Handle symptoms in Mild to moderate AsthmaticsHugues Malonne
Department of Physiology and Pharmacology, Free University of Brussels, Boulevard du Triomphe, 1050 Brussels, Belgium
Curr Med Res Opin 18:512-9. 2002....
- Reasons for and costs of hospitalization for pediatric asthma: a prospective 1-year follow-up in a population-based settingK Korhonen
Department of Paediatrics, Kuopio University Hospital, Kuopio, Finland
Pediatr Allergy Immunol 12:331-8. 2001..The cost of regular medication for asthma was, on average, $272 per admitted child on maintenance. The annual total cost as a result of asthma rose eight-fold if a child on regular medication was admitted for asthma...
- Clinical symptoms and 'off-label' prescribing in children with asthmaColin McCowan
Tayside Centre for General Practice, University of Dundee, Dundee, UK
Br J Gen Pract 57:220-2. 2007..Off-label prescribing for children with asthma in UK primary care is associated with worse levels of self-reported asthma control...
- Budesonide/formoterol maintenance plus reliever therapy: a new strategy in pediatric asthmaHans Bisgaard
Danish Pediatric Asthma Center, Department of Pediatrics, Copenhagen University Hospital, Gentofte, DK 2900 Copenhagen, Denmark
Chest 130:1733-43. 2006....
- Effects of montelukast on surrogate inflammatory markers in corticosteroid-treated patients with asthmaGraeme P Currie
Asthma and Allergy Research Group, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, UK
Am J Respir Crit Care Med 167:1232-8. 2003..Further studies are required to evaluate whether these effects of montelukast translate into clinical benefits...
- Underuse of controller medications among Medicaid-insured children with asthmaJonathan A Finkelstein
Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, 133 Brookline Ave, 6th Floor, Boston, MA 02215, USA
Arch Pediatr Adolesc Med 156:562-7. 2002..Although studies suggest low rates of controller use, little is known about predictors of underuse among low-income children in whom asthma morbidity is greatest...
- High-dose inhaled corticosteroid use in childhood asthma: an observational study of GP prescribingMike Thomas
Department of General Practice and Primary Care, University of Aberdeen, Foresterhill Health Centre, Westburn Road, Aberdeen AB25 2AY
Br J Gen Pract 56:788-90. 2006..Add-on therapy was lacking for almost half of these individuals. Some children were receiving treatment not in accord with current licences and evidence-based recommendations and, as such, may be at risk of adverse outcomes...
- Salmeterol powder provides significantly better benefit than montelukast in asthmatic patients receiving concomitant inhaled corticosteroid therapyJ E Fish
Jefferson Medical College, Philadelphia, PA 19107 5083, USA
Chest 120:423-30. 2001..Comparison of inhaled salmeterol powder vs oral montelukast treatment in patients with persistent asthma who remained symptomatic while receiving inhaled corticosteroids...
- CANNABINOIDS AND CYTOCHROME P-450 GENE EXPRESSIONDALE DEUTSCH; Fiscal Year: 1992..The 3rd set of experiments are designed to relate the changes found at the level of a specific cytochrome P-450 genes to the activity of the corresponding enzymes employing isozyme specific substrates...
- Chemistry of Lithium EnolatesDavid B Collum; Fiscal Year: 2013..The project originated from collaboration with Sanofi-Aventis to develop anti-asthmatics. The proposed funding period includes a collaboration with Amgen as part of their program to synthesize treatments for colorectal cancer. ..
- A CELL LINE FOR ANTIASTHMA DRUG DISCOVERYWeihua Yuan; Fiscal Year: 2004....
- NEBULIZER INTERVENTION IN MINORITY CHILDREN WITH ASTHMAArlene Butz; Fiscal Year: 2004..Study findings will improve clinical care to this vulnerable population of children and will be if significant use to health care providers, researchers, insurers and policy makers. ..
- A+ Asthma Rural PartnershipArlene Butz; Fiscal Year: 2004..The findings of this study will be important to clinicians, researchers, and health policy makers. ..
- HOME NURSE INTERVENTION FOR IUDE INFANTS--3 YR FOLLOW UPArlene Butz; Fiscal Year: 2002..Data will be of significant use to researchers, health care providers, insurers and policy makers. ..
- Childhood Asthma Research and Education Network: Denver SiteStanley Szefler; Fiscal Year: 2008..End of abstract.) [unreadable] [unreadable]..
- Improving Asthma Communication in Minority FamiliesArlene Butz; Fiscal Year: 2007..abstract_text> ..
- Adherence & Treatment Outcome in Adolescents in CAMPCSBruce Bender; Fiscal Year: 2003..abstract_text> ..
- ASSESSMENT MODE AND VALIDITY OF SELF-REPORTS IN CHILDRENBruce Bender; Fiscal Year: 2004..Results from this investigation are expected to have immediate and direct implication for clinical research in asthma and with other chronic conditions. ..
- Improving Follow-up After an Emergency Visit for AsthmaJoseph Zorc; Fiscal Year: 2007..The expected goal of the project will be to develop an intervention that can subsequently be tested in a newly developed, federally-funded research network of pediatric EDs. ..
- Severe Asthma From Respiratory InfectionsWilliam W Busse; Fiscal Year: 2010..These studies will provide new insights into the mechanisms of asthma, particularly severe disease, and possibilities of new approaches to treatment. ..
- Pediatric Severe Asthma: Role of Oxidant Stress and Alveolar Macrophage FunctionAnne Fitzpatrick; Fiscal Year: 2009..This proposal will lay the foundation for further studies, and the mechanisms identified may ultimately be targeted in future interventional trials. ..
- MECHANISMS OF RHINOVIRUS INDUCED ASTHMAWilliam Busse; Fiscal Year: 2002..The proposed studies will provide new evidence as the mechanisms by which RV-infected epithelial cells cause granulocytic bronchial inflammation and asthma exacerbations. ..
- INFLAMMATION & CORTICOSTEROID RESPONSES IN SEVERE ASTHMAKIAN CHUNG; Fiscal Year: 2005..The molecular mechanisms underlying loss of CR will be examined. These studies should lead to more effective therapies for chronic severe asthma. ..
- School-Based Approaches to Help Pre-Teens Manage AsthmaNoreen Clark; Fiscal Year: 2007..Asthma rates for this age group continue to rise and the problems associated with the disease are especially difficult in poor communities. This study will assess innovative interventions for low-income minority preteens with asthma. ..
- PHARMACOGENETICS OF ASTHMA MONOTHERAPYJohn Lima; Fiscal Year: 2005..The results of this pharmacogenetic study may facilitate the optimal selection of monotherapy in asthma. ..
- LEUKOTRIENE POLYMORPHISMS & MONTELUKAST RESPONSEJohn Lima; Fiscal Year: 2003..This information may lead to individualization of asthma medications based on the genetic make-up of the patient. ..
- EFFECT OF HEART DISEASE EDUCATION ON OLDER WOMENNoreen Clark; Fiscal Year: 2001....
- EFFECT OF SELF-REGULATORY EDUCATION ON WOMEN WITH ASTHMANoreen Clark; Fiscal Year: 2004..abstract_text> ..
- ADHESION MOLECULES IN SMOOTH MUSCLE ACTIVATION & GROWTHAILI LAZAAR; Fiscal Year: 2003..Understanding the mechanisms by which CAMs transduce signals that could induce myocyte activation may provide insight in new therapeutic measures to prevent airway inflammation and bronchial hyperreactivity. ..
- Innovative Investigations and Therapies for AsthmaRichard Martin; Fiscal Year: 2007..The ability to predict who will and will not respond to corticosteroids and additive therapy will greatly improve our ability to treat asthma effectively. ..
- Trial of Asthma Patient Education in the Emergency RoomCarol Mancuso; Fiscal Year: 2009..Other long-term objectives are to use the program as a basis for similar programs for children, adolescents and their caregivers in the ED, primary care, and school settings. ..
- ASTHMA CLINICAL RESEARCH NETWORKROBERT LEMANSKE; Fiscal Year: 2002....
- Project ASPIRE: Improving Pediatric Asthma Management for Urban FamiliesMarianne Celano; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Asthma Management Support Training in PediatricsPaula Lozano; Fiscal Year: 2007..In addition, this novel project will advance the field by providing tools for training pediatricians in collaborative management. [unreadable] [unreadable] [unreadable]..
- Treatment of Severe Persistent AsthmaROBERT LEMANSKE; Fiscal Year: 2007..abstract_text> ..
- INHALED STEROID ADHERENCE IN MODERATE & SEVERE ASTHMAAndrea Apter; Fiscal Year: 2004..Upon the foundation of my prior clinical experience and education, this training program is designed to equip me with the additional skills and research experience necessary to become a fully independent investigator. ..
- ASTHMA CLINICAL RESEARCH NETWORK (ACRN)Stephen Peters; Fiscal Year: 2007....
- Oxidative Stress and Anti-Inflammatory Lipids in Airway DiseaseBruce D Levy; Fiscal Year: 2010..In this proposal, we seek to develop a better understanding of the natural biological processes invoked during airway infection and inflammation that dysregulate the natural homeostatic mechanisms. (End of Abstract) ..
- Mechanism of Endotoxin's Effect On Allergy RiskKeoki Williams; Fiscal Year: 2008..It is the hoped that understanding the mechanism of endotoxin's effect will establish new targets for the prevention of allergies. ..
- Response to Beta2-Agonists in Acute Severe AsthmaNicola Hanania; Fiscal Year: 2008..abstract_text> ..
- USING INFORMATION TECHNOLOGY TO IMPROVE ASTHMA ADHERENCEKeoki Williams; Fiscal Year: 2008..abstract_text> ..
- The Effect of Mycoplasma on Chronic AsthmaRichard Martin; Fiscal Year: 2008..pneumoniae and asthma will be obtained through this PPG and will ultimately give new knowledge to the understanding of asthma pathophysiology and potential future novel therapies. ..
- CYTOKINE DYSREGULATION, VIRUSES, AND CHILDHOOD ASTHMAROBERT LEMANSKE; Fiscal Year: 2001..The results of these studies will provide information that will be a major step forward in our understanding of the relative influence that genetic and environmental risk factors on the development of childhood asthma. ..
- CARE Network - Madison Clinical CenterROBERT LEMANSKE; Fiscal Year: 2008..abstract_text> ..
- ASTHMA CLINICAL RESEARCH NETWORK (ACRN)Richard Martin; Fiscal Year: 2002....
- Severe Asthma and the Glucocorticoid Receptor ComplexGregory Hawkins; Fiscal Year: 2006..This will also lay the ground work for future functional studies using coding sequence variants identified in the GR complex proteins. [unreadable] [unreadable] [unreadable]..
- CARE Network-UCSD Clinical CenterRobert Zeiger; Fiscal Year: 2008..abstract_text> ..
- RANDOMIZED TRIAL--COMPUTERIZED ASTHMA MANAGEMENT SYSTEMPaula Lozano; Fiscal Year: 2003..abstract_text> ..
- ASTHMA CHRONOBIOLOGY: CENTRAL AND LUNG INTERACTIONSRichard Martin; Fiscal Year: 2003....
- Effect of Chinese herbal medicine on food allergyXiu Min Li; Fiscal Year: 2010....
- MEKK2 Regulation of Mast Cell/T Cell Cytokine ProductionErwin Gelfand; Fiscal Year: 2003..The studies will also define MEKK2 and ERK5 as targets for drug discovery for the control of allergic inflammation. ..
- CONTROL OF IGE MEDIATED PULMONARY INFLAMMATION IN HUMANSStephen Peters; Fiscal Year: 2001....
- Lipid Mediators in the Resolution of Asthma ExacerbationsBruce Levy; Fiscal Year: 2008..This proposal's specific aims are directed towards uncovering basic mechanisms in the pathobiology of resolution from asthma exacerbation. ..
- Effects of Chinese Herbal Medicines on Allergic AsthmaXiu Min Li; Fiscal Year: 2003..Accomplishing these goals should provide an experimental basis for applying Chinese herbal medicines to the treatment of allergic asthma, and for understanding immunoregulatory mechanisms underlying their effects. ..
- Platelet-Derived Growth Factor, Remodeling and AsthmaMonica Kraft; Fiscal Year: 2010..This proposal will also determine whether PDGF inhibition could provide important adjuvant therapy for the treatment of severe asthmatics by limiting structural changes that result from activity of this pathway. ..
- THE CLINICAL EFFECTIVENESS OF PHARMACY ADHERENCE INFORMATION FOR DIABETES CONTROLKeoki Williams; Fiscal Year: 2010..Analyses will control for cluster randomization effects. The introduction of sustainable medication adherence monitoring in clinical practice holds great potential to improve health outcomes among patients with diabetes. ..
- COMMUNITY PARTNERSHIP TO REDUCE ASTHMA DISPARITIESElizabeth McQuaid; Fiscal Year: 2009..A Sustainability Advisory board will provide guidance regarding project implementation in the community beyond the life of the grant. ..
- Individualized Interventions to Improve Asthma AdherenceAndrea Apter; Fiscal Year: 2009..We will estimate the incremental cost-effectiveness of PS. ..
- Neglect, Adherence and Depression in Asthmatic ChildrenMarianne Celano; Fiscal Year: 2005..abstract_text> ..
- Naturally occurring T regulatory cells control airway hyperresponsivenessErwin Gelfand; Fiscal Year: 2008..abstract_text> ..
- TESTING INTERVENTIONS IN PEDIATRIC ASTHMAElizabeth McQuaid; Fiscal Year: 2002..Exploratory analyses will investigate mediators of behavior change. Results will be used to design a larger, randomized controlled trial comparing behavioral feedback to asthma education. ..
- NOVEL LUNG DERIVED CHALONES--BIOSYNTHESIS AND BIOACTIONSBruce Levy; Fiscal Year: 2002..End of Abstract) ..
- The Placebo Effect in AsthmaRobert Wise; Fiscal Year: 2005..Understanding the placebo response can lead to improvements in research and treatment of asthma. ..
- Obstruction in Asthma--Role of Airway ClosureAndrew Jackson; Fiscal Year: 2003..If we can demonstrate that asthma includes a major component of airway closure, this may very well identify a new direction for future research, which may lead to entirely new treatment approaches. ..
- INNATE IMMUNITY IN HEART, LUNG, AND BLOOD DISEASEFernando Martinez; Fiscal Year: 2003..abstract_text> ..
- Paraxanthine and Reproductive Effects of CaffeineMichael Bracken; Fiscal Year: 2004..abstract_text> ..
- Blood lead levels and development of asthmaChristine Joseph; Fiscal Year: 2002....
- DIET AND CHRONIC OBSTRUCTIVE PULMONARY DISEASECarlos Camargo; Fiscal Year: 2002..The proposed study is cost-effective, as it makes use of an existing cohort, and it will provide information that could have direct clinical application to reduce risk of COPD. ..
- Center for the Spatiotemporal Modeling of Cell SignalingJANET OLIVER; Fiscal Year: 2007..The Center will place high demands on its biomedical, mathematical, statistical and computational scientists and will provide exceptional opportunities for young researchers to build exciting and productive careers. ..
- Prospective Study of Dietary Factors, BMI, and Risk of Asthma in ChildrenCarlos Camargo; Fiscal Year: 2008..The proposed study is cost-effective, as it makes use of an existing cohort, and it will provide information that could have direct clinical application to reduce risk of asthma. [unreadable] [unreadable] [unreadable] [unreadable]..
- Prospective Study of Diet, Physical Activity, BMI and Risk of Pulmonary EmbolismCarlos Camargo; Fiscal Year: 2008..We believe that quantifying these modifiable risk factors will lead to public health interventions that decrease the incidence of pulmonary embolism in the elderly population. [unreadable] [unreadable] [unreadable]..
- SCLERODERMA LUNG STUDYRobert Wise; Fiscal Year: 2003..abstract_text> ..
- Surfactant-Protein Innate Immunity in an Asthma ModelAngela Haczku; Fiscal Year: 2008..The potential opportunity to interfere with allergic sensitization by SP-D treatment bears high clinical significance. [unreadable] [unreadable]..
- Evaluating the Effectiveness of Lung Cancer Treatment in the ElderlyJuan Wisnivesky; Fiscal Year: 2009..The findings from this project will provide information that can directly impact the care of elderly patients with NSCLC and inform the design of future trials of lung cancer treatment strategies. ..
- Novel Treatment for Septicemia Targets A1 ARsCONSTANCE WILSON; Fiscal Year: 2004..Endacea estimates that there were 1.2 million cases of Gram-negative septicemia in 2000 worldwide with a potential market size of $3.8 billion worldwide. ..
- A Novel Treatment in a Bioterrorism Model of Pneumonic Plague Targets A1 ARsCONSTANCE WILSON; Fiscal Year: 2007..pestis, rapid therapeutic modulation of pneumonic plague-associated ALI by novel treatments such as L-97-1 could be essential to national biodefense. [unreadable] [unreadable] [unreadable]..
- Myocardial Salvage With a Novel Reperfusion TherapyCONSTANCE WILSON; Fiscal Year: 2005..abstract_text> ..
- Regulation of Inflammation in Asthma by Fas LigandAngela Haczku; Fiscal Year: 2009..Finally, in order to help support the hypothesis that pro-apoptotic FasL activity characterized in human airway cells is truly physiologic, we will perform challenge studies in mice under FasL neutralizing conditions. ..