anti asthmatic agents

Summary

Summary: Drugs that are used to treat asthma.

Top Publications

  1. ncbi Worldwide severity and control of asthma in children and adults: the global asthma insights and reality surveys
    Klaus F Rabe
    Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands
    J Allergy Clin Immunol 114:40-7. 2004
  2. pmc Attitudes and actions of asthma patients on regular maintenance therapy: the INSPIRE study
    Martyn R Partridge
    Department of Respiratory Medicine, Faculty of Medicine, Imperial College London, London, UK
    BMC Pulm Med 6:13. 2006
  3. ncbi Measurement properties and interpretation of three shortened versions of the asthma control questionnaire
    Elizabeth F Juniper
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Canada
    Respir Med 99:553-8. 2005
  4. ncbi Identifying 'well-controlled' and 'not well-controlled' asthma using the Asthma Control Questionnaire
    Elizabeth F Juniper
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Canada
    Respir Med 100:616-21. 2006
  5. pmc Shared treatment decision making improves adherence and outcomes in poorly controlled asthma
    Sandra R Wilson
    Palo Alto Medical Foundation Research Institute, CA 94301, USA
    Am J Respir Crit Care Med 181:566-77. 2010
  6. ncbi Compliance, adherence, and concordance: implications for asthma treatment
    Rob Horne
    Behavioural Medicine Research Unit, School of Pharmacy and Biomolecular Sciences, University of Brighton, Room 409, Watts Building, Lewes Rd, Brighton, BN2 4GJ, UK
    Chest 130:65S-72S. 2006
  7. ncbi Evidence of remodeling in peripheral airways of patients with mild to moderate asthma: effect of hydrofluoroalkane-flunisolide
    Celine Bergeron
    Meakins Christie Laboratories, McGill University, Montreal, Quebec, Canada
    J Allergy Clin Immunol 116:983-9. 2005
  8. pmc Dose-response relation of inhaled fluticasone propionate in adolescents and adults with asthma: meta-analysis
    S Holt
    Wellington Asthma Research Group, Wellington School of Medicine, PO Box 7343, Wellington, New Zealand
    BMJ 323:253-6. 2001
  9. ncbi Effect of obesity on clinical presentation and response to treatment in asthma
    Anne E Dixon
    University of Vermont, Burlington, VT 05401, USA
    J Asthma 43:553-8. 2006
  10. ncbi Suppression of cytokine expression by roflumilast and dexamethasone in a model of chronic asthma
    C Herbert
    Department of Pathology, School of Medical Sciences, University of New South Wales, Sydney, Australia
    Clin Exp Allergy 38:847-56. 2008

Research Grants

Detail Information

Publications253 found, 100 shown here

  1. ncbi Worldwide severity and control of asthma in children and adults: the global asthma insights and reality surveys
    Klaus F Rabe
    Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands
    J Allergy Clin Immunol 114:40-7. 2004
    ..In 1995, the Global Initiative for Asthma (GINA) guidelines recommended goals for the management of asthma, which were updated in 2002. However, there are no recent international surveys on the real management of asthma...
  2. pmc Attitudes and actions of asthma patients on regular maintenance therapy: the INSPIRE study
    Martyn R Partridge
    Department of Respiratory Medicine, Faculty of Medicine, Imperial College London, London, UK
    BMC Pulm Med 6:13. 2006
    ....
  3. ncbi Measurement properties and interpretation of three shortened versions of the asthma control questionnaire
    Elizabeth F Juniper
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Canada
    Respir Med 99:553-8. 2005
    ..5. In conclusion, these three shortened versions of the ACQ can be used in large clinical trials without loss of validity or change in interpretation...
  4. ncbi Identifying 'well-controlled' and 'not well-controlled' asthma using the Asthma Control Questionnaire
    Elizabeth F Juniper
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Canada
    Respir Med 100:616-21. 2006
    ....
  5. pmc Shared treatment decision making improves adherence and outcomes in poorly controlled asthma
    Sandra R Wilson
    Palo Alto Medical Foundation Research Institute, CA 94301, USA
    Am J Respir Crit Care Med 181:566-77. 2010
    ..Poor adherence to asthma controller medications results in poor treatment outcomes...
  6. ncbi Compliance, adherence, and concordance: implications for asthma treatment
    Rob Horne
    Behavioural Medicine Research Unit, School of Pharmacy and Biomolecular Sciences, University of Brighton, Room 409, Watts Building, Lewes Rd, Brighton, BN2 4GJ, UK
    Chest 130:65S-72S. 2006
    ..This approach, based on a detailed examination of patients' perspectives on asthma and its treatment, and an open, nonjudgmental manner on the part of the clinician, is consistent with the idea of concordance...
  7. ncbi Evidence of remodeling in peripheral airways of patients with mild to moderate asthma: effect of hydrofluoroalkane-flunisolide
    Celine Bergeron
    Meakins Christie Laboratories, McGill University, Montreal, Quebec, Canada
    J Allergy Clin Immunol 116:983-9. 2005
    ..It is not clear whether inflammation of the peripheral airways is associated with structural changes and whether this remodeling process can be modulated by deposition of inhaled corticosteroids (ICSs)...
  8. pmc Dose-response relation of inhaled fluticasone propionate in adolescents and adults with asthma: meta-analysis
    S Holt
    Wellington Asthma Research Group, Wellington School of Medicine, PO Box 7343, Wellington, New Zealand
    BMJ 323:253-6. 2001
    ..However, these findings were limited by the lack of data on individual patients and by the paucity of dose-response studies that included doses of >500 microg/day...
  9. ncbi Effect of obesity on clinical presentation and response to treatment in asthma
    Anne E Dixon
    University of Vermont, Burlington, VT 05401, USA
    J Asthma 43:553-8. 2006
    ..Obese and non-obese asthmatics have similar lung function abnormalities, but comorbidities and altered responses to medications may significantly affect asthma control in obese people...
  10. ncbi Suppression of cytokine expression by roflumilast and dexamethasone in a model of chronic asthma
    C Herbert
    Department of Pathology, School of Medical Sciences, University of New South Wales, Sydney, Australia
    Clin Exp Allergy 38:847-56. 2008
    ..In a mouse model of mild chronic asthma, both inflammation and remodelling can be suppressed by dexamethasone (a glucocorticoid) and roflumilast (a selective phosphodiesterase-4 inhibitor)...
  11. ncbi Are overweight asthmatics more difficult to control?
    P Saint-Pierre
    Institut Universitaire de Recherche Clinique, Laboratoire de Biostatistique, Montpellier, France
    Allergy 61:79-84. 2006
    ..Because control of asthma clearly drives asthma management, this finding has consequences for defining original new strategies for managing asthma in overweight patients...
  12. ncbi New targets for drug development in asthma
    Ian M Adcock
    Airways Disease Section, National Heart and Lung Institute, Imperial College London, London, UK
    Lancet 372:1073-87. 2008
    ..Although a cure is unlikely to be developed in the near future, a greater understanding of disease mechanisms could bring such a situation nearer to reality...
  13. ncbi Long-term comparison of 3 controller regimens for mild-moderate persistent childhood asthma: the Pediatric Asthma Controller Trial
    Christine A Sorkness
    Clinical Science Center, University of Wisconsin, Madison, WI 53792, USA
    J Allergy Clin Immunol 119:64-72. 2007
    ..More evidence is needed on which to base recommendations for treatment of mild-moderate persistent asthma in school-aged children...
  14. ncbi Zafirlukast improves asthma control in patients receiving high-dose inhaled corticosteroids
    J C Virchow
    Department of Pneumology, University Medical Clinic Freiburg, Germany and AstraZeneca Pharmaceuticals, Macclesfield, United Kingdom
    Am J Respir Crit Care Med 162:578-85. 2000
    ....
  15. ncbi The effect of treatment with omalizumab, an anti-IgE antibody, on asthma exacerbations and emergency medical visits in patients with severe persistent asthma
    J Bousquet
    Hopital Arnaud de Villeneuve, Montpellier, France
    Allergy 60:302-8. 2005
    ..Such patients are at high risk of serious exacerbations and asthma-related mortality...
  16. ncbi Effects of mast cell membrane stabilizing agents in a rat lung ischemia-reperfusion model
    K M Vural
    Department of Cardiothoracic Surgery, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    Ann Thorac Surg 69:228-32. 2000
    ....
  17. ncbi Identification of asthmatic children using prescription data and diagnosis
    Grete Moth
    Danish Paediatric Asthma Centre, Aarhus University Hospital Skejby Sygehus, Aarhus N, Denmark
    Eur J Clin Pharmacol 63:605-11. 2007
    ..The aim of the study was to develop and validate a method for identifying asthmatic children between 6 and 14 years of age based on prescription data on anti-asthmatic drugs and diagnostic data...
  18. ncbi A meta-analysis of the dose-response relationship of inhaled corticosteroids in adolescents and adults with mild to moderate persistent asthma
    Jean Bousquet
    Service des Maladies Respiratoires, Hopital Arnaud de Villeneuve, Centre Hospitalier Universitaire Montpellier, France
    Clin Ther 24:1-20. 2002
    ..Although inhaled corticosteroids (ICS) are commonly used in the treatment of persistent asthma, the relationship between dose and clinical response remains unclear...
  19. ncbi Particulate levels are associated with early asthma worsening in children with persistent disease
    Nathan Rabinovitch
    Division of Allergy and Immunology, Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    Am J Respir Crit Care Med 173:1098-105. 2006
    ..Ambient particulate concentrations have been associated with variable physiologic effects in children with persistent asthma taking controller medications...
  20. pmc Self-management of asthma in general practice, asthma control and quality of life: a randomised controlled trial
    B P A Thoonen
    Department of General Practice Family Medicine, University Medical Centre Nijmegen, The Netherlands
    Thorax 58:30-6. 2003
    ..A study was undertaken to determine the effectiveness of asthma self-management in general practice...
  21. ncbi Adherence to asthma controller medication regimens
    D A Stempel
    Department of Pediatrics, Infomed Northwest and University of Washington, Bellevue, WA 98004, USA
    Respir Med 99:1263-7. 2005
    ....
  22. ncbi The gap between evidence-based medicine and daily practice in the management of paediatric asthma. A pharmacy-based population study from The Netherlands
    Tjalling W de Vries
    Department of Paediatrics, Medical Centre Leeuwarden, P O Box 888, 8901 BR, Leeuwarden, The Netherlands
    Eur J Clin Pharmacol 62:51-5. 2006
    ..We evaluated the adherence to national guidelines for the treatment of asthma in childhood...
  23. pmc Effect of montelukast added to inhaled budesonide on control of mild to moderate asthma
    M J Vaquerizo
    Merck Sharp and Dohme, c Josefa Valcarcel 38, 28027 Madrid, Spain
    Thorax 58:204-10. 2003
    ..A 16 week multicentre, randomised, double blind, controlled study was undertaken to study the efficacy of adding oral montelukast, a leukotriene receptor antagonist, to a constant dose of inhaled budesonide...
  24. ncbi Inhaled corticosteroids: past lessons and future issues
    David B Allen
    Division of Endocrinology, University of Wisconsin Children s Hospital, Madison 53792 4108, USA
    J Allergy Clin Immunol 112:S1-40. 2003
    ....
  25. ncbi A new perspective on concepts of asthma severity and control
    D R Taylor
    Dunedin School of Medicine, University of Otago, PO Box 913, Dunedin, New Zealand
    Eur Respir J 32:545-54. 2008
    ..These markers can also act as surrogate measures for future risk...
  26. ncbi Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial
    Ruth H Green
    Institute for Lung Health, Department of Respiratory Medicine and Thoracic Surgery, Glenfield Hospital, LE3 9PQ, Leicester, UK
    Lancet 360:1715-21. 2002
    ..We aimed to assess whether a management strategy that minimises eosinophilic inflammation reduces asthma exacerbations compared with a standard management strategy...
  27. ncbi The use of anti-asthmatic medications among pediatric patients in Taiwan
    Chi Yu Chen
    Graduate Institute of Pharmaceutical Sciences, Kaohsiung Medical University, 100 Shih Chuan 1st Road, Kaohsiung 80708, Taiwan
    Pharmacoepidemiol Drug Saf 12:129-33. 2003
    ..To describe the use of anti-asthma drugs in Taiwanese pediatric patients...
  28. ncbi Effect of montelukast on lung function in asthma patients with allergic rhinitis: analysis from the COMPACT trial
    D B Price
    Department of General Practice and Primary Care, University of Aberdeen, Foresterhill Health Centre, Aberdeen UK
    Allergy 61:737-42. 2006
    ..This analysis was designed to examine whether asthmatic patients with comorbid AR respond differently than patients without comorbid AR in terms of asthma control (lung function)...
  29. ncbi Transient receptor potential and other ion channels as pharmaceutical targets in airway smooth muscle cells
    Hwei L Ong
    Department of Medical Biochemistry, School of Medicine, Flinders University, Adelaide, South Australia, Australia
    Respirology 9:448-57. 2004
    ....
  30. ncbi Systemic effects of inhaled fluticasone propionate and budesonide in adult patients with asthma
    E Derom
    Department of Respiratory Diseases, University Hospital of Ghent, Ghent, Belgium
    Am J Respir Crit Care Med 160:157-61. 1999
    ..We conclude that high doses of BUD and FP (in particular the latter), inhaled via their respective dry powder inhalers for 1 wk, result in a measurable systemic activity in patients with asthma...
  31. ncbi Second-line controller therapy for persistent asthma uncontrolled on inhaled corticosteroids: the step 3 dilemma
    Brian J Lipworth
    Department of Clinical Pharmacology and Therapeutics, Asthma and Allergy Research Group, Ninewells University Hospital and Medical School, University of Dundee, Dundee, Scotland, UK
    Drugs 62:2315-32. 2002
    ..For the patient whose lung function is less impaired, with evidence of ongoing BHR where bronchoprotection is needed (e.g. exercise, allergen, cold air), or when there is concomitant allergic rhinitis, then an LTA would be more suitable...
  32. ncbi Inhaler devices in infants and children: challenges and solutions
    Mark L Everard
    Department of Respiratory Medicine, Sheffield Children s Hospital, Sheffield, United Kingdom
    J Aerosol Med 17:186-95. 2004
  33. ncbi Pretreatment of cromolyn sodium prior to reperfusion attenuates early reperfusion injury after the small intestine ischemia in rats
    Zi Qing Hei
    Department of Anesthesiology, The Third Affiliated Hospital, Sun Yat Sen University, Guangzhou 510630, Guangdong Province, China
    World J Gastroenterol 13:5139-46. 2007
    ..To investigate the effects of Cromolyn Sodium (CS) pretreated prior to reperfusion on the activity of intestinal mucosal mast cells (IMMC) and mucous membrane of the small intestine in ischemia-reperfusion (IR) injury of rats...
  34. ncbi Therapeutic ratio of inhaled corticosteroids in adult asthma. A dose-range comparison between fluticasone propionate and budesonide, measuring their effect on bronchial hyperresponsiveness and adrenal cortex function
    L P Nielsen
    Department of Respiratory Diseases, Aarhus University Hospital, Aarhus, Denmark
    Am J Respir Crit Care Med 162:2053-7. 2000
    ..Therapeutic ratio over a wide dose range, determined by impact on bronchial responsiveness and endogenous corticosteroid production, seems to favor FP...
  35. ncbi Can guideline-defined asthma control be achieved? The Gaining Optimal Asthma ControL study
    Eric D Bateman
    UCT Lung Institute, P O Box 34560, Groote Schuur 7937, Cape Town, South Africa
    Am J Respir Crit Care Med 170:836-44. 2004
    ..07-0.27 per patient per year) and improvement in health status were significantly better with salmeterol/fluticasone. This study confirms that the goal of guideline-derived asthma control was achieved in a majority of the patients...
  36. ncbi Addition of montelukast or salmeterol to fluticasone for protection against asthma attacks: a randomized, double-blind, multicenter study
    Jonathan Ilowite
    Winthrop University Hospital, Pulmonary and Critical Care Division, Mineola, New York 11501, USA
    Ann Allergy Asthma Immunol 92:641-8. 2004
    ..For patients whose asthma is uncontrolled with low-dose inhaled corticosteroids, addition of alternative therapy instead of increasing the steroid dose is recommended by current treatment guidelines...
  37. pmc Anti-leukotrienes as add-on therapy to inhaled glucocorticoids in patients with asthma: systematic review of current evidence
    Francine M Ducharme
    Department of Paediatrics, McGill University Health Centre, Montreal, QC H3H 1P3, Canada
    BMJ 324:1545. 2002
    ..To examine the evidence for the efficacy and glucocorticoid sparing effect of oral anti-leukotrienes taken daily as add-on therapy to inhaled glucocorticoids in patients with asthma...
  38. ncbi Severe asthma: an overview
    Wendy C Moore
    Center for Human Genomics, and Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Allergy Clin Immunol 117:487-94; quiz 495. 2006
    ..Treatment algorithms based on markers of airway inflammation may decrease measures of health care utilization in severe asthma...
  39. ncbi Improvement of aspirin-intolerant asthma by montelukast, a leukotriene antagonist: a randomized, double-blind, placebo-controlled trial
    Sven Erik Dahlen
    Experimental Asthma and Allergy Research, The National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Am J Respir Crit Care Med 165:9-14. 2002
    ..Addition of a leukotriene receptor antagonist such as montelukast improves asthma in aspirin-intolerant patients over and above what can be achieved by glucocorticosteroids...
  40. ncbi Significant variability in response to inhaled corticosteroids for persistent asthma
    Stanley J Szefler
    National Jewish Medical and Research Center, Department of Pediatrics, Denver, CO 80206, USA
    J Allergy Clin Immunol 109:410-8. 2002
    ..A clinical model is needed to compare inhaled corticosteroids (ICSs) with respect to efficacy...
  41. ncbi Inadequate use of asthma medication in the United States: results of the asthma in America national population survey
    Robert J Adams
    Department of Medicine, University of Adelaide, The Queen Elizabeth Hospital Campus, Woodville, Australia
    J Allergy Clin Immunol 110:58-64. 2002
    ..Studies of the use of anti-inflammatory asthma therapy have been limited to selected populations or have been unable to assess the appropriateness of therapy for individuals...
  42. ncbi Allergic rhinitis: a potential cause of increased asthma medication use, costs, and morbidity
    Michael T Halpern
    Exponent Inc, Alexandria, Virginia, USA
    J Asthma 41:117-26. 2004
    ..Physicians should assess asthma patients for symptoms of allergic rhinitis to improve asthma treatment...
  43. pmc Montelukast and fluticasone compared with salmeterol and fluticasone in protecting against asthma exacerbation in adults: one year, double blind, randomised, comparative trial
    Leif Bjermer
    Department of Respiratory Medicine and Allergology, University Hospital, SE 221 85 Lund, Sweden
    BMJ 327:891. 2003
    ..Design and setting A 52 week, two period, double blind, multicentre trial during which patients whose symptoms remained uncontrolled by inhaled corticosteroids were randomised to add montelukast or salmeterol...
  44. ncbi [Cost and management of asthma exacerbations in Spanish hospitals (COAX study in hospital services)]
    L Borderias Clau
    Servicio de Neumologia, Hospital San Jorge, Huesca, Spain
    Arch Bronconeumol 41:313-21. 2005
    ..The study formed part of a broader study (COAX II), with the same objectives in each of the 8 participating European countries...
  45. ncbi Exhaled NO and assessment of anti-inflammatory effects of inhaled steroid: dose-response relationship
    S L Jones
    Dept of Medical and Surgical Sciences, Dunedin School of Medicine, University of Otago, New Zealand
    Eur Respir J 20:601-8. 2002
    ..The relationship found in this study was linear over the dose range 0-500 microg x day(-1) soon after commencing therapy and continued over time...
  46. ncbi Do regular check ups and preventive drug use reduce asthma severity in school children?
    Lyle J Palmer
    Schools of Medicine, Pharmacology and Population Health, University of Western Australia
    Aust Fam Physician 33:573-6. 2004
    ..To investigate whether regular check ups and preventive drug use reduce asthma symptoms in school children...
  47. pmc Randomised controlled trial of montelukast plus inhaled budesonide versus double dose inhaled budesonide in adult patients with asthma
    D B Price
    Department of General Practice and Primary Care, University of Aberdeen, Foresterhill Health Centre, Westburn Road, Aberdeen AB25 2AY, Scotland, UK
    Thorax 58:211-6. 2003
    ..This double blind, randomised, parallel group, non-inferiority, multicentre 16 week study compared the clinical benefits of adding montelukast to budesonide with doubling the budesonide dose in adults with asthma...
  48. ncbi [Asthma epidemiology]
    Isabella Annesi-Maesano
    Epidémiologie des Maladies Allergiques et Respiratoires, INSERM U472 Epidémiologie et Biostatistique, 16, avenue Paul Vaillant Couturier, 94807 Villejuif
    Rev Prat 55:1295-8. 2005
    ..Gene-environment interactions already in early life should be explored to understand asthma epidemiological evolution...
  49. ncbi Glycyrrhizin alleviates experimental allergic asthma in mice
    Arjun Ram
    Molecular Immunogenetics Laboratory, Institute of Genomics and Integrative Biology, Mall Road, Delhi 110007, India
    Int Immunopharmacol 6:1468-77. 2006
    ..We have also showed that it has no effect on serum cortisol levels. Our results demonstrate that GRZ alleviates asthmatic features in mice and it could be useful towards developing a better therapeutic molecule in the future...
  50. ncbi Fluticasone propionate nasal spray is superior to montelukast for allergic rhinitis while neither affects overall asthma control
    Robert A Nathan
    Asthma and Allergy Associates, P C, 2709 North Tejon St, Colorado Springs, CO 80907, USA
    Chest 128:1910-20. 2005
    ..Asthma and allergic rhinitis are both highly prevalent diseases and often coexist in patients...
  51. ncbi Inappropriate use of anti-asthmatic drugs in the Italian paediatric population
    Antonio Clavenna
    Laboratory for Mother and Child Health, Mario Negri Institute for Pharmacological Research, Milan, Italy
    Eur J Clin Pharmacol 59:565-9. 2003
    ..To evaluate anti-asthmatic drug prescriptions in a large Italian paediatric population...
  52. ncbi Population pharmacokinetics and pharmacodynamics of ciclesonide
    S Rohatagi
    Aventis Pharmaceuticals Mail Stop BWM 203F, Route 202 206, P O Box 6800, Bridgewater, NJ 08807 0800, USA
    J Clin Pharmacol 43:365-78. 2003
    ..The disposition and effect of CIC-AP can be described using mixed-effect modeling. The estimated EC50 is similar to mean Cmax from an 800-micrograms dose, further suggesting CIC-AP has little effect on cortisol suppression...
  53. ncbi Healthcare and workloss costs associated with patients with persistent asthma in a privately insured population
    G Colice
    Washington Hospital Center, Washington, DC, USA
    J Occup Environ Med 48:794-802. 2006
    ..The objective of this study was to estimate annual healthcare and workloss costs of patients with persistent asthma by severity...
  54. pmc Allergic rhinitis: evidence for impact on asthma
    Mike Thomas
    Department of General Practice and Primary Care, University of Aberdeen, Foresterhill Health Centre, Westburn Road, Aberdeen AB25 2AY, UK
    BMC Pulm Med 6:S4. 2006
    ..This paper reviews the current evidence indicating that comorbid allergic rhinitis may have clinically relevant effects on asthma...
  55. ncbi Asthma control in patients with asthma and allergic rhinitis receiving add-on montelukast therapy for 12 months: a retrospective observational study
    Luis Borderias
    Pneumology Department, San Jorge Hospital, Huesca, Spain
    Curr Med Res Opin 23:721-30. 2007
    ..No studies to date have examined whether montelukast can improve asthma control over a long period of time in patients with seasonal AR and asthma...
  56. ncbi Understanding the pathogenesis of allergic asthma using mouse models
    K P Leong
    Department of Rheumatology and Immunology, Tan Tock Seng Hospital, Singapore
    Ann Allergy Asthma Immunol 87:96-109; quiz 110,. 2001
    ..The reader will also encounter new treatment strategies that have arisen as this knowledge is applied in practice...
  57. ncbi Response of preschool children with asthma symptoms to fluticasone propionate
    R J Roorda
    Department of Pediatrics, Isala Klinieken, De Weezenlanden Hospital, Zwolle, The Netherlands
    J Allergy Clin Immunol 108:540-6. 2001
    ..These findings may help to predict treatment outcome and guide the management of preschool children with recurrent asthma symptoms...
  58. ncbi Low-dose inhaled corticosteroids and the prevention of death from asthma
    S Suissa
    Division of Clinical Epidemiology, Royal Victoria Hospital, McGill University Health Centre, Montreal, QC, Canada
    N Engl J Med 343:332-6. 2000
    ..Although inhaled corticosteroids are effective for the treatment of asthma, it is uncertain whether their use can prevent death from asthma...
  59. ncbi Budesonide/formoterol for maintenance and relief in uncontrolled asthma vs. high-dose salmeterol/fluticasone
    Jean Bousquet
    Hopital Arnaud de Villeneuve, 371 Avenue Doyen Gaston Giraud, FR 34000 Montpellier, France
    Respir Med 101:2437-46. 2007
    ....
  60. ncbi Pharmacokinetics and anti-asthmatic potential of non-parenterally administered recombinant human interleukin-1 receptor antagonist in animal models
    Ting Li
    State Key Laboratory of Natural and Biomimetic Drugs and School of Pharmaceutical Sciences, Peking University, Beijing, China
    J Pharmacol Sci 102:321-30. 2006
    ....
  61. ncbi Addition of salmeterol to low-dose fluticasone versus higher-dose fluticasone: an analysis of asthma exacerbations
    J Matz
    Atlantic Asthma and Allergy Center, Inc, Baltimore, MD, USA
    J Allergy Clin Immunol 107:783-9. 2001
    ..The ability to detect deteriorating asthma and the severity of exacerbation was similar between groups...
  62. ncbi Anti-asthmatic drugs and dosage forms in children: a cross-sectional study
    Eric Schirm
    Department of Social Pharmacy and Pharmacoepidemiology, Groningen University Institute for Drug Exploration GUIDE, Groningen, The Netherlands
    Pharm World Sci 24:162-5. 2002
    ..To describe the choice of drugs as well as the dosage forms of anti-asthmatic drugs in children with regard to different age groups...
  63. ncbi Effect of inhaled ciclesonide on airway responsiveness to inhaled AMP, the composition of induced sputum and exhaled nitric oxide in patients with mild asthma
    F Kanniess
    Pulmonary Research Institute, Hospital Grosshansdorf, Grosshansdorf, D 22927, Germany
    Pulm Pharmacol Ther 14:141-7. 2001
    ..These data suggest that ciclesonide is equi-effective to budesonide with regard to its potency to reduce the airway responsiveness to inhaled AMP as well as airway inflammation in patients with mild asthma...
  64. ncbi Treatment of chronic rhinosinusitis and its effects on asthma
    S Ragab
    Tanta University Hospitals, Tanta, Egypt
    Eur Respir J 28:68-74. 2006
    ..Treatment of chronic rhinosinusitis, medical or surgical, benefits concomitant asthma; that associated with nasal polyposis benefits more from medical therapy...
  65. ncbi Systemic adverse effects of inhaled corticosteroid therapy: A systematic review and meta-analysis
    B J Lipworth
    Department of Clinical Pharmacology and Therapeutics and Respiratory Medicine, Ninewells Hospital and Medical School, University of Dundee, Scotland
    Arch Intern Med 159:941-55. 1999
    ..To appraise the data on systemic adverse effects of inhaled corticosteroids...
  66. ncbi Circadian rhythm of serum cortisol after repeated inhalation of the new topical steroid ciclesonide
    Anita Weinbrenner
    Department of Clinical Pharmacology, Ernst Moritz Arndt University, Greifswald 17487, Germany
    J Clin Endocrinol Metab 87:2160-3. 2002
    ....
  67. ncbi Self-reported adherence in patients with asthma
    Brian D De Smet
    Department of Pharmacy Services, University of Michigan Hospitals and Health Centers, Ann Arbor, 48109, USA
    Ann Pharmacother 40:414-20. 2006
    ..The Behavioral Model of Health Services Utilization, organized as predisposing, enabling, and need variables, may be useful in identifying variables related to adherent medication-taking behavior...
  68. ncbi Use of anti-asthmatic medications as a proxy for prevalence of asthma in children and adolescents in Norway: a nationwide prescription database analysis
    Kari Furu
    Department of Pharmacoepidemiology, Division of Epidemiology, Norwegian Institute of Public Health, PO Box 4404, Nydalen, 0403 Oslo, Norway
    Eur J Clin Pharmacol 63:693-8. 2007
    ..The aim of this study was to assess the prevalence of dispensed anti-asthmatic medications as a proxy of asthma among children and adolescents aged 0-19 years in Norway...
  69. ncbi Bronchial thermoplasty for asthma
    Gerard Cox
    M B, Firestone Institute for Respiratory Health T2123, St Joseph s Healthcare, 50 Charlton Avenue, East Hamilton, ON L8N 4A6, Canada
    Am J Respir Crit Care Med 173:965-9. 2006
    ..Bronchial thermoplasty (BT) reduces the potential for smooth muscle-mediated bronchoconstriction by reducing the mass of smooth muscle in the walls of conducting airways...
  70. ncbi Costs of asthma treatment in Estonia
    R A Kiivet
    University of Tartu, Department of Public Health, Ravila 19, EE 50411, Tartu, Estonia
    Eur J Public Health 11:89-92. 2001
    ..The total estimated direct costs of asthma diagnosis and treatment during 1997, as extrapolated from the study population, were 2.1 million EUR, and accounted for 1.4% of direct health care costs in Estonia...
  71. ncbi Association of low-level ozone and fine particles with respiratory symptoms in children with asthma
    Janneane F Gent
    Center for Perinatal, Pediatric, and Environmental Epidemiology, Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Conn 06510, USA
    JAMA 290:1859-67. 2003
    ..Exposure to ozone and particulate matter of 2.5 microm or less (PM2.5) in air at levels above current US Environmental Protection Agency (EPA) standards is a risk factor for respiratory symptoms in children with asthma...
  72. ncbi [Cost-of-illness of asthma in Denmark in the year 2000]
    Robert Mossing
    Afdeling for Epidemiologi, Arbejdsmiljøinstituttet, Lersø Parkallé 105, DK 2100 København
    Ugeskr Laeger 165:2646-9. 2003
    ..The total number of asthmatic patients in Denmark in the year 2000 was about 300,000 out of a total population of 5.3 million. The aim of this study was to evaluate cost-of-illness for all asthma patients in Denmark for the year 2000...
  73. ncbi Cost, morbidity, and control of asthma in Hungary: The Hunair Study
    Iren Herjavecz
    National Koranyi Institute of TBC and Pulmonology, Budapest, Hungary
    J Asthma 40:673-81. 2003
    ..To assess asthma-related morbidity, symptom control, and societal cost of asthmatic patients in Hungary. Secondary objective was to assess the relationship between asthma symptom control and costs incurred...
  74. ncbi Clinical equivalence of salmeterol/fluticasone propionate in combination (50/100 microg twice daily) when administered via a chlorofluorocarbon-free metered dose inhaler or dry powder inhaler to patients with mild-to-moderate asthma
    E D Bateman
    UCT Lung Institute, Groote Schuur, Cape Town, South Africa
    Respir Med 95:136-46. 2001
    ..Patients switching to SALM/FP from other MDI-based asthma treatments may now do so without a change of delivery device...
  75. pmc Comparison of the systemic effects of fluticasone propionate and budesonide given by dry powder inhaler in healthy and asthmatic subjects
    T W Harrison
    Division of Respiratory Medicine, Nottingham City Hospital, Nottingham NG5 1PB, UK
    Thorax 56:186-91. 2001
    ....
  76. ncbi Azithromycin reduces bronchial hyperresponsiveness and neutrophilic airway inflammation in asthmatic children: a preliminary report
    Giorgio L Piacentini
    Department of Pediatrics, University of Verona, Verona, Italy
    Allergy Asthma Proc 28:194-8. 2007
    ..2 +/- 4.2% at baseline and 3.3 +/- 3.6% at the end of the study. A short course of azithromycin is associated with amelioration of BHR and reduction in airway neutrophil infiltration in some children with asthma...
  77. ncbi Short-acting beta 2-agonist and oral corticosteroid use in asthma patients prescribed either concurrent beclomethasone and long-acting beta 2-agonist or salmeterol/fluticasone propionate combination
    R Angus
    Aintree Chest Centre, Liverpool L9 7AL, UK
    Int J Clin Pract 59:156-62. 2005
    ..In clinical practice, adding LABA to IC therapy by using a combination inhaler produces significantly better asthma control than administering the drugs in separate inhalers...
  78. ncbi Increased risk of asthma attacks and emergency visits among asthma patients with allergic rhinitis: a subgroup analysis of the investigation of montelukast as a partner agent for complementary therapy [corrected]
    J Bousquet
    Service des Maladies Respiratoires, Hopital Arnaud de Villeneuve, Montpellier, Cedex 5, France
    Clin Exp Allergy 35:723-7. 2005
    ..We assessed asthma-related medical resource use and attacks in asthmatic patients who did and did not have concomitant AR and were adding montelukast or salmeterol to baseline treatment with inhaled fluticasone...
  79. pmc Childhood asthma
    N M Clark
    University of Michigan School of Public Health Department of Health, Behavior and Health Education, Ann Arbor 48109 2029, USA
    Environ Health Perspect 107:421-9. 1999
    ....
  80. ncbi Has asthma medication use in children become more frequent, more appropriate, or both?
    D C Goodman
    Center for the Evaluative Clinical Sciences, Department of Community and Family Medicine, University of Washington, Seattle, USA
    Pediatrics 104:187-94. 1999
    ..This study measures trends and recent patterns in the pediatric use of medications approved for reversible obstructive airway disease (asthma medications)...
  81. ncbi Effectiveness of pharmacotherapy in asthmatic preschool children
    J C de Jongste
    Department of Pediatrics, Division Pediatric Respiratory Medicine, Erasmus University and University Hospital Sophia Children s Hospital, Rotterdam, The Netherlands
    Allergy 57:42-7. 2002
    ..Also, we need methods to separate the different phenotypes within the group of recurrently wheezing preschool children to optimize targeting of asthma treatment to those who have ongoing airway inflammation...
  82. ncbi A single inhaler for asthma?
    Peter J Barnes
    Am J Respir Crit Care Med 171:95-6. 2005
  83. ncbi Asthma treatment preference study: a conjoint analysis of preferred drug treatments
    Gunnar Johansson
    Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden
    Chest 125:916-23. 2004
    ..Assessment of patient preferences for attributes of asthma treatments...
  84. pmc A Danish population-based cohort study of newly diagnosed asthmatic children's care pathway - adherence to guidelines
    Grete Moth
    Danish Paediatric Asthma Centre, Aarhus University Hospital, Skejby, Denmark
    BMC Health Serv Res 8:130. 2008
    ..The aim of the study was to analyse associations between care providers and adherence to guidelines concerning frequency of contacts with the health service due to asthma...
  85. ncbi Improved refill persistence with fluticasone propionate and salmeterol in a single inhaler compared with other controller therapies
    Stuart W Stoloff
    University of Nevada School of Medicine, Reno, Nev, USA
    J Allergy Clin Immunol 113:245-51. 2004
    ..Improved adherence to inhaled corticosteroids (ICSs) has also been associated with decreased asthma-associated morbidity and mortality...
  86. ncbi Design and baseline characteristics of the epidemiology and natural history of asthma: Outcomes and Treatment Regimens (TENOR) study: a large cohort of patients with severe or difficult-to-treat asthma
    Chantal M Dolan
    Genentech Inc, South San Francisco, California 94080, USA
    Ann Allergy Asthma Immunol 92:32-9. 2004
    ..The goal of The Epidemiology and Natural History of Asthma: Outcomes and Treatment Regimens (TENOR) study is to better understand the natural history of asthma in these patients...
  87. ncbi Twelve-month safety and efficacy of inhaled fluticasone propionate in children aged 1 to 3 years with recurrent wheezing
    Hans Bisgaard
    Department of Pediatrics, Copenhagen University Hospital, Copenhagen, Denmark
    Pediatrics 113:e87-94. 2004
    ..Our aim was to compare the 12-month safety and efficacy of fluticasone propionate (FP) and sodium cromoglycate (SCG) in children aged 1 to 3 years with mild to moderate recurrent wheeze...
  88. ncbi Development of the satisfaction with inhaled asthma treatment questionnaire
    J L Campbell
    Peninsula Medical School, Exeter, UK
    Eur Respir J 22:127-34. 2003
    ..The Satisfaction with Asthma Treatment Questionnaire is potentially a useful instrument for gaining insight into patient satisfaction with inhaled treatment for asthma...
  89. ncbi Inhaled corticosteroids reduce bone mineral density in early postmenopausal but not premenopausal asthmatic women
    K Fujita
    University of Shiga Prefecture, Hikone, Japan
    J Bone Miner Res 16:782-7. 2001
    ..Ovarian hormones may be protective against the adverse effect of inhaled BDP on bone metabolism in the premenopausal patients...
  90. ncbi Does your child have asthma? Filled prescriptions and household report of child asthma
    Jutta M Joesch
    Battelle Centers for Public Health Research and Evaluation, Seattle, Washington 98109 3598, USA
    J Pediatr Health Care 20:374-83. 2006
    ..Confidence is examined in the report of asthma for children, obtained in a survey from the adult household member most knowledgeable about household health care (MKA)...
  91. ncbi The role of long-acting beta-agonists in the management of asthma: analysis, meta-analysis, and more analysis
    Jeffrey Glassroth
    Ann Intern Med 144:936-7. 2006
  92. ncbi The economic impact of children dispensed asthma medications without an asthma diagnosis
    David A Stempel
    Infomed Northwest Bellevue and University of Washington, Bellevue, Washington 98004, USA
    J Pediatr 148:819-23. 2006
    ..To compare the resource utilization and healthcare costs of children with a diagnosis of asthma, children dispensed asthma medications but without a diagnosis of asthma, and control children...
  93. ncbi Impact of montelukast on symptoms in mild-to-moderate persistent asthma and exercise-induced asthma: results of the ASTHMA survey. Adding Singulair Treatment to Handle symptoms in Mild to moderate Asthmatics
    Hugues Malonne
    Department of Physiology and Pharmacology, Free University of Brussels, Boulevard du Triomphe, 1050 Brussels, Belgium
    Curr Med Res Opin 18:512-9. 2002
    ....
  94. ncbi Reasons for and costs of hospitalization for pediatric asthma: a prospective 1-year follow-up in a population-based setting
    K Korhonen
    Department of Paediatrics, Kuopio University Hospital, Kuopio, Finland
    Pediatr Allergy Immunol 12:331-8. 2001
    ..The cost of regular medication for asthma was, on average, $272 per admitted child on maintenance. The annual total cost as a result of asthma rose eight-fold if a child on regular medication was admitted for asthma...
  95. pmc Clinical symptoms and 'off-label' prescribing in children with asthma
    Colin McCowan
    Tayside Centre for General Practice, University of Dundee, Dundee, UK
    Br J Gen Pract 57:220-2. 2007
    ..Off-label prescribing for children with asthma in UK primary care is associated with worse levels of self-reported asthma control...
  96. ncbi Budesonide/formoterol maintenance plus reliever therapy: a new strategy in pediatric asthma
    Hans Bisgaard
    Danish Pediatric Asthma Center, Department of Pediatrics, Copenhagen University Hospital, Gentofte, DK 2900 Copenhagen, Denmark
    Chest 130:1733-43. 2006
    ....
  97. ncbi Effects of montelukast on surrogate inflammatory markers in corticosteroid-treated patients with asthma
    Graeme P Currie
    Asthma and Allergy Research Group, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, UK
    Am J Respir Crit Care Med 167:1232-8. 2003
    ..Further studies are required to evaluate whether these effects of montelukast translate into clinical benefits...
  98. ncbi Underuse of controller medications among Medicaid-insured children with asthma
    Jonathan A Finkelstein
    Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, 133 Brookline Ave, 6th Floor, Boston, MA 02215, USA
    Arch Pediatr Adolesc Med 156:562-7. 2002
    ..Although studies suggest low rates of controller use, little is known about predictors of underuse among low-income children in whom asthma morbidity is greatest...
  99. pmc High-dose inhaled corticosteroid use in childhood asthma: an observational study of GP prescribing
    Mike Thomas
    Department of General Practice and Primary Care, University of Aberdeen, Foresterhill Health Centre, Westburn Road, Aberdeen AB25 2AY
    Br J Gen Pract 56:788-90. 2006
    ..Add-on therapy was lacking for almost half of these individuals. Some children were receiving treatment not in accord with current licences and evidence-based recommendations and, as such, may be at risk of adverse outcomes...
  100. ncbi Salmeterol powder provides significantly better benefit than montelukast in asthmatic patients receiving concomitant inhaled corticosteroid therapy
    J E Fish
    Jefferson Medical College, Philadelphia, PA 19107 5083, USA
    Chest 120:423-30. 2001
    ..Comparison of inhaled salmeterol powder vs oral montelukast treatment in patients with persistent asthma who remained symptomatic while receiving inhaled corticosteroids...

Research Grants73

  1. CANNABINOIDS AND CYTOCHROME P-450 GENE EXPRESSION
    DALE DEUTSCH; Fiscal Year: 1992
    ..The 3rd set of experiments are designed to relate the changes found at the level of a specific cytochrome P-450 genes to the activity of the corresponding enzymes employing isozyme specific substrates...
  2. Chemistry of Lithium Enolates
    David B Collum; Fiscal Year: 2013
    ..The project originated from collaboration with Sanofi-Aventis to develop anti-asthmatics. The proposed funding period includes a collaboration with Amgen as part of their program to synthesize treatments for colorectal cancer. ..
  3. A CELL LINE FOR ANTIASTHMA DRUG DISCOVERY
    Weihua Yuan; Fiscal Year: 2004
    ....
  4. NEBULIZER INTERVENTION IN MINORITY CHILDREN WITH ASTHMA
    Arlene Butz; Fiscal Year: 2004
    ..Study findings will improve clinical care to this vulnerable population of children and will be if significant use to health care providers, researchers, insurers and policy makers. ..
  5. A+ Asthma Rural Partnership
    Arlene Butz; Fiscal Year: 2004
    ..The findings of this study will be important to clinicians, researchers, and health policy makers. ..
  6. HOME NURSE INTERVENTION FOR IUDE INFANTS--3 YR FOLLOW UP
    Arlene Butz; Fiscal Year: 2002
    ..Data will be of significant use to researchers, health care providers, insurers and policy makers. ..
  7. Childhood Asthma Research and Education Network: Denver Site
    Stanley Szefler; Fiscal Year: 2008
    ..End of abstract.) [unreadable] [unreadable]..
  8. Improving Asthma Communication in Minority Families
    Arlene Butz; Fiscal Year: 2007
    ..abstract_text> ..
  9. Adherence & Treatment Outcome in Adolescents in CAMPCS
    Bruce Bender; Fiscal Year: 2003
    ..abstract_text> ..
  10. ASSESSMENT MODE AND VALIDITY OF SELF-REPORTS IN CHILDREN
    Bruce Bender; Fiscal Year: 2004
    ..Results from this investigation are expected to have immediate and direct implication for clinical research in asthma and with other chronic conditions. ..
  11. Improving Follow-up After an Emergency Visit for Asthma
    Joseph Zorc; Fiscal Year: 2007
    ..The expected goal of the project will be to develop an intervention that can subsequently be tested in a newly developed, federally-funded research network of pediatric EDs. ..
  12. Severe Asthma From Respiratory Infections
    William W Busse; Fiscal Year: 2010
    ..These studies will provide new insights into the mechanisms of asthma, particularly severe disease, and possibilities of new approaches to treatment. ..
  13. Pediatric Severe Asthma: Role of Oxidant Stress and Alveolar Macrophage Function
    Anne Fitzpatrick; Fiscal Year: 2009
    ..This proposal will lay the foundation for further studies, and the mechanisms identified may ultimately be targeted in future interventional trials. ..
  14. MECHANISMS OF RHINOVIRUS INDUCED ASTHMA
    William Busse; Fiscal Year: 2002
    ..The proposed studies will provide new evidence as the mechanisms by which RV-infected epithelial cells cause granulocytic bronchial inflammation and asthma exacerbations. ..
  15. INFLAMMATION & CORTICOSTEROID RESPONSES IN SEVERE ASTHMA
    KIAN CHUNG; Fiscal Year: 2005
    ..The molecular mechanisms underlying loss of CR will be examined. These studies should lead to more effective therapies for chronic severe asthma. ..
  16. School-Based Approaches to Help Pre-Teens Manage Asthma
    Noreen Clark; Fiscal Year: 2007
    ..Asthma rates for this age group continue to rise and the problems associated with the disease are especially difficult in poor communities. This study will assess innovative interventions for low-income minority preteens with asthma. ..
  17. PHARMACOGENETICS OF ASTHMA MONOTHERAPY
    John Lima; Fiscal Year: 2005
    ..The results of this pharmacogenetic study may facilitate the optimal selection of monotherapy in asthma. ..
  18. LEUKOTRIENE POLYMORPHISMS & MONTELUKAST RESPONSE
    John Lima; Fiscal Year: 2003
    ..This information may lead to individualization of asthma medications based on the genetic make-up of the patient. ..
  19. EFFECT OF HEART DISEASE EDUCATION ON OLDER WOMEN
    Noreen Clark; Fiscal Year: 2001
    ....
  20. EFFECT OF SELF-REGULATORY EDUCATION ON WOMEN WITH ASTHMA
    Noreen Clark; Fiscal Year: 2004
    ..abstract_text> ..
  21. ADHESION MOLECULES IN SMOOTH MUSCLE ACTIVATION & GROWTH
    AILI LAZAAR; Fiscal Year: 2003
    ..Understanding the mechanisms by which CAMs transduce signals that could induce myocyte activation may provide insight in new therapeutic measures to prevent airway inflammation and bronchial hyperreactivity. ..
  22. Innovative Investigations and Therapies for Asthma
    Richard Martin; Fiscal Year: 2007
    ..The ability to predict who will and will not respond to corticosteroids and additive therapy will greatly improve our ability to treat asthma effectively. ..
  23. Trial of Asthma Patient Education in the Emergency Room
    Carol Mancuso; Fiscal Year: 2009
    ..Other long-term objectives are to use the program as a basis for similar programs for children, adolescents and their caregivers in the ED, primary care, and school settings. ..
  24. ASTHMA CLINICAL RESEARCH NETWORK
    ROBERT LEMANSKE; Fiscal Year: 2002
    ....
  25. Project ASPIRE: Improving Pediatric Asthma Management for Urban Families
    Marianne Celano; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  26. Asthma Management Support Training in Pediatrics
    Paula Lozano; Fiscal Year: 2007
    ..In addition, this novel project will advance the field by providing tools for training pediatricians in collaborative management. [unreadable] [unreadable] [unreadable]..
  27. Treatment of Severe Persistent Asthma
    ROBERT LEMANSKE; Fiscal Year: 2007
    ..abstract_text> ..
  28. INHALED STEROID ADHERENCE IN MODERATE & SEVERE ASTHMA
    Andrea Apter; Fiscal Year: 2004
    ..Upon the foundation of my prior clinical experience and education, this training program is designed to equip me with the additional skills and research experience necessary to become a fully independent investigator. ..
  29. ASTHMA CLINICAL RESEARCH NETWORK (ACRN)
    Stephen Peters; Fiscal Year: 2007
    ....
  30. Oxidative Stress and Anti-Inflammatory Lipids in Airway Disease
    Bruce D Levy; Fiscal Year: 2010
    ..In this proposal, we seek to develop a better understanding of the natural biological processes invoked during airway infection and inflammation that dysregulate the natural homeostatic mechanisms. (End of Abstract) ..
  31. Mechanism of Endotoxin's Effect On Allergy Risk
    Keoki Williams; Fiscal Year: 2008
    ..It is the hoped that understanding the mechanism of endotoxin's effect will establish new targets for the prevention of allergies. ..
  32. Response to Beta2-Agonists in Acute Severe Asthma
    Nicola Hanania; Fiscal Year: 2008
    ..abstract_text> ..
  33. USING INFORMATION TECHNOLOGY TO IMPROVE ASTHMA ADHERENCE
    Keoki Williams; Fiscal Year: 2008
    ..abstract_text> ..
  34. The Effect of Mycoplasma on Chronic Asthma
    Richard Martin; Fiscal Year: 2008
    ..pneumoniae and asthma will be obtained through this PPG and will ultimately give new knowledge to the understanding of asthma pathophysiology and potential future novel therapies. ..
  35. CYTOKINE DYSREGULATION, VIRUSES, AND CHILDHOOD ASTHMA
    ROBERT LEMANSKE; Fiscal Year: 2001
    ..The results of these studies will provide information that will be a major step forward in our understanding of the relative influence that genetic and environmental risk factors on the development of childhood asthma. ..
  36. CARE Network - Madison Clinical Center
    ROBERT LEMANSKE; Fiscal Year: 2008
    ..abstract_text> ..
  37. ASTHMA CLINICAL RESEARCH NETWORK (ACRN)
    Richard Martin; Fiscal Year: 2002
    ....
  38. Severe Asthma and the Glucocorticoid Receptor Complex
    Gregory Hawkins; Fiscal Year: 2006
    ..This will also lay the ground work for future functional studies using coding sequence variants identified in the GR complex proteins. [unreadable] [unreadable] [unreadable]..
  39. CARE Network-UCSD Clinical Center
    Robert Zeiger; Fiscal Year: 2008
    ..abstract_text> ..
  40. RANDOMIZED TRIAL--COMPUTERIZED ASTHMA MANAGEMENT SYSTEM
    Paula Lozano; Fiscal Year: 2003
    ..abstract_text> ..
  41. ASTHMA CHRONOBIOLOGY: CENTRAL AND LUNG INTERACTIONS
    Richard Martin; Fiscal Year: 2003
    ....
  42. Effect of Chinese herbal medicine on food allergy
    Xiu Min Li; Fiscal Year: 2010
    ....
  43. MEKK2 Regulation of Mast Cell/T Cell Cytokine Production
    Erwin Gelfand; Fiscal Year: 2003
    ..The studies will also define MEKK2 and ERK5 as targets for drug discovery for the control of allergic inflammation. ..
  44. CONTROL OF IGE MEDIATED PULMONARY INFLAMMATION IN HUMANS
    Stephen Peters; Fiscal Year: 2001
    ....
  45. Lipid Mediators in the Resolution of Asthma Exacerbations
    Bruce Levy; Fiscal Year: 2008
    ..This proposal's specific aims are directed towards uncovering basic mechanisms in the pathobiology of resolution from asthma exacerbation. ..
  46. Effects of Chinese Herbal Medicines on Allergic Asthma
    Xiu Min Li; Fiscal Year: 2003
    ..Accomplishing these goals should provide an experimental basis for applying Chinese herbal medicines to the treatment of allergic asthma, and for understanding immunoregulatory mechanisms underlying their effects. ..
  47. Platelet-Derived Growth Factor, Remodeling and Asthma
    Monica Kraft; Fiscal Year: 2010
    ..This proposal will also determine whether PDGF inhibition could provide important adjuvant therapy for the treatment of severe asthmatics by limiting structural changes that result from activity of this pathway. ..
  48. THE CLINICAL EFFECTIVENESS OF PHARMACY ADHERENCE INFORMATION FOR DIABETES CONTROL
    Keoki Williams; Fiscal Year: 2010
    ..Analyses will control for cluster randomization effects. The introduction of sustainable medication adherence monitoring in clinical practice holds great potential to improve health outcomes among patients with diabetes. ..
  49. COMMUNITY PARTNERSHIP TO REDUCE ASTHMA DISPARITIES
    Elizabeth McQuaid; Fiscal Year: 2009
    ..A Sustainability Advisory board will provide guidance regarding project implementation in the community beyond the life of the grant. ..
  50. Individualized Interventions to Improve Asthma Adherence
    Andrea Apter; Fiscal Year: 2009
    ..We will estimate the incremental cost-effectiveness of PS. ..
  51. Neglect, Adherence and Depression in Asthmatic Children
    Marianne Celano; Fiscal Year: 2005
    ..abstract_text> ..
  52. Naturally occurring T regulatory cells control airway hyperresponsiveness
    Erwin Gelfand; Fiscal Year: 2008
    ..abstract_text> ..
  53. TESTING INTERVENTIONS IN PEDIATRIC ASTHMA
    Elizabeth McQuaid; Fiscal Year: 2002
    ..Exploratory analyses will investigate mediators of behavior change. Results will be used to design a larger, randomized controlled trial comparing behavioral feedback to asthma education. ..
  54. NOVEL LUNG DERIVED CHALONES--BIOSYNTHESIS AND BIOACTIONS
    Bruce Levy; Fiscal Year: 2002
    ..End of Abstract) ..
  55. The Placebo Effect in Asthma
    Robert Wise; Fiscal Year: 2005
    ..Understanding the placebo response can lead to improvements in research and treatment of asthma. ..
  56. Obstruction in Asthma--Role of Airway Closure
    Andrew Jackson; Fiscal Year: 2003
    ..If we can demonstrate that asthma includes a major component of airway closure, this may very well identify a new direction for future research, which may lead to entirely new treatment approaches. ..
  57. INNATE IMMUNITY IN HEART, LUNG, AND BLOOD DISEASE
    Fernando Martinez; Fiscal Year: 2003
    ..abstract_text> ..
  58. Paraxanthine and Reproductive Effects of Caffeine
    Michael Bracken; Fiscal Year: 2004
    ..abstract_text> ..
  59. Blood lead levels and development of asthma
    Christine Joseph; Fiscal Year: 2002
    ....
  60. DIET AND CHRONIC OBSTRUCTIVE PULMONARY DISEASE
    Carlos Camargo; Fiscal Year: 2002
    ..The proposed study is cost-effective, as it makes use of an existing cohort, and it will provide information that could have direct clinical application to reduce risk of COPD. ..
  61. Center for the Spatiotemporal Modeling of Cell Signaling
    JANET OLIVER; Fiscal Year: 2007
    ..The Center will place high demands on its biomedical, mathematical, statistical and computational scientists and will provide exceptional opportunities for young researchers to build exciting and productive careers. ..
  62. Prospective Study of Dietary Factors, BMI, and Risk of Asthma in Children
    Carlos Camargo; Fiscal Year: 2008
    ..The proposed study is cost-effective, as it makes use of an existing cohort, and it will provide information that could have direct clinical application to reduce risk of asthma. [unreadable] [unreadable] [unreadable] [unreadable]..
  63. Prospective Study of Diet, Physical Activity, BMI and Risk of Pulmonary Embolism
    Carlos Camargo; Fiscal Year: 2008
    ..We believe that quantifying these modifiable risk factors will lead to public health interventions that decrease the incidence of pulmonary embolism in the elderly population. [unreadable] [unreadable] [unreadable]..
  64. SCLERODERMA LUNG STUDY
    Robert Wise; Fiscal Year: 2003
    ..abstract_text> ..
  65. Surfactant-Protein Innate Immunity in an Asthma Model
    Angela Haczku; Fiscal Year: 2008
    ..The potential opportunity to interfere with allergic sensitization by SP-D treatment bears high clinical significance. [unreadable] [unreadable]..
  66. Evaluating the Effectiveness of Lung Cancer Treatment in the Elderly
    Juan Wisnivesky; Fiscal Year: 2009
    ..The findings from this project will provide information that can directly impact the care of elderly patients with NSCLC and inform the design of future trials of lung cancer treatment strategies. ..
  67. Novel Treatment for Septicemia Targets A1 ARs
    CONSTANCE WILSON; Fiscal Year: 2004
    ..Endacea estimates that there were 1.2 million cases of Gram-negative septicemia in 2000 worldwide with a potential market size of $3.8 billion worldwide. ..
  68. A Novel Treatment in a Bioterrorism Model of Pneumonic Plague Targets A1 ARs
    CONSTANCE WILSON; Fiscal Year: 2007
    ..pestis, rapid therapeutic modulation of pneumonic plague-associated ALI by novel treatments such as L-97-1 could be essential to national biodefense. [unreadable] [unreadable] [unreadable]..
  69. Myocardial Salvage With a Novel Reperfusion Therapy
    CONSTANCE WILSON; Fiscal Year: 2005
    ..abstract_text> ..
  70. Regulation of Inflammation in Asthma by Fas Ligand
    Angela Haczku; Fiscal Year: 2009
    ..Finally, in order to help support the hypothesis that pro-apoptotic FasL activity characterized in human airway cells is truly physiologic, we will perform challenge studies in mice under FasL neutralizing conditions. ..