renal agents

Summary

Summary: Drugs used for their effects on the kidneys' regulation of body fluid composition and volume. The most commonly used are the diuretics. Also included are drugs used for their antidiuretic and uricosuric actions, for their effects on the kidneys' clearance of other drugs, and for diagnosis of renal function.

Top Publications

  1. ncbi Inhibition of endocytosis causes phosphorylation (S256)-independent plasma membrane accumulation of AQP2
    Hua Lu
    Program in Membrane Biology, Renal Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Am J Physiol Renal Physiol 286:F233-43. 2004
  2. ncbi UT-B1 proteins in rat: tissue distribution and regulation by antidiuretic hormone in kidney
    M M Trinh-Trang-Tan
    Institut National de la Santé et de la Recherche Médicale Unité 76, Institut National de la Transfusion Sanguine, 75015 Paris, France
    Am J Physiol Renal Physiol 283:F912-22. 2002
  3. ncbi Hyponatremia associated with desmopressin for the treatment of nocturnal polyuria
    Alan Shindel
    Washington University School of Medicine, St Louis, Missouri, USA
    Urology 60:344. 2002
  4. ncbi Impact of urodynamics in treatment of primary nocturnal enuresis persisting into adulthood
    Selcuk Yucel
    Department of Urology, Akdeniz University School of Medicine, Kampus, Antalya, Turkey
    Urology 64:1020-5; discussion 1025. 2004
  5. ncbi N-ethylmaleimide causes aquaporin-2 trafficking in the renal inner medullary collecting duct by direct activation of protein kinase A
    Stephen Shaw
    School of Biomedical Sciences, Worsley Bldg, Univ of Leeds, Leeds LS2 9NQ, United Kingdom
    Am J Physiol Renal Physiol 288:F832-9. 2005
  6. ncbi Angiotensin II AT1 receptor blockade decreases vasopressin-induced water reabsorption and AQP2 levels in NaCl-restricted rats
    Tae Hwan Kwon
    The Water and Salt Research Ctr, Bldg 233 234, Univ of Aarhus, DK 8000 Aarhus C, Denmark
    Am J Physiol Renal Physiol 288:F673-84. 2005
  7. ncbi Bidirectional regulation of AQP2 trafficking and recycling: involvement of AQP2-S256 phosphorylation
    Lene N Nejsum
    The Water and Salt Research Center, University of Aarhus, DK 8000 Aarhus, Denmark
    Am J Physiol Renal Physiol 288:F930-8. 2005
  8. ncbi Collecting duct-specific knockout of endothelin-1 alters vasopressin regulation of urine osmolality
    Yuqiang Ge
    Division of Nephrology, University of Utah Health Sciences Center, 30 North 1900 East, Salt Lake City, Utah 84132, USA
    Am J Physiol Renal Physiol 288:F912-20. 2005
  9. pmc Coupling of vasopressin-induced intracellular Ca2+ mobilization and apical exocytosis in perfused rat kidney collecting duct
    Kay Pong Yip
    Department of Physiology and Biophysics, College of Medicine, University of South Florida, Tampa, FL 33612, USA
    J Physiol 538:891-9. 2002
  10. ncbi Altered expression of COX-1, COX-2, and mPGES in rats with nephrogenic and central diabetes insipidus
    Primoz Kotnik
    The Water and Salt Research Center, University of Aarhus, DK 8000 Aarhus C, Denmark
    Am J Physiol Renal Physiol 288:F1053-68. 2005

Research Grants

  1. Ginkgo biloba for ECT-induced Memory Deficits
    JOHN MARKOWITZ; Fiscal Year: 2003
  2. P-Glycoprotein and Disposition of Psychostimulants
    JOHN MARKOWITZ; Fiscal Year: 2005
  3. Sgk1 in Na+ transport in fetal lung epithelia
    Christie Thomas; Fiscal Year: 2007
  4. NEUROPEPTIDES AND SALT APPETITE
    FRANCIS FLYNN; Fiscal Year: 2007
  5. Neuroscience Center for Biomedical Research Excellence
    Francis W Flynn; Fiscal Year: 2010
  6. Screening Herbs for Drug Interactions
    JOHN MARKOWITZ; Fiscal Year: 2002
  7. REGULATION AND FUNCTION OF THE ALPHA SUBUNIT OF ENAC
    Christie Thomas; Fiscal Year: 2003

Detail Information

Publications171 found, 100 shown here

  1. ncbi Inhibition of endocytosis causes phosphorylation (S256)-independent plasma membrane accumulation of AQP2
    Hua Lu
    Program in Membrane Biology, Renal Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Am J Physiol Renal Physiol 286:F233-43. 2004
    ....
  2. ncbi UT-B1 proteins in rat: tissue distribution and regulation by antidiuretic hormone in kidney
    M M Trinh-Trang-Tan
    Institut National de la Santé et de la Recherche Médicale Unité 76, Institut National de la Transfusion Sanguine, 75015 Paris, France
    Am J Physiol Renal Physiol 283:F912-22. 2002
    ..This study discloses an uneven distribution of UT-B1 protein within astrocytes and the regulation of renal UT-B1 protein by antidiuretic hormone...
  3. ncbi Hyponatremia associated with desmopressin for the treatment of nocturnal polyuria
    Alan Shindel
    Washington University School of Medicine, St Louis, Missouri, USA
    Urology 60:344. 2002
    ..We report the cases of two elderly women taking DDAVP for nocturnal polyuria who developed severe hyponatremia. One patient died in the hospital...
  4. ncbi Impact of urodynamics in treatment of primary nocturnal enuresis persisting into adulthood
    Selcuk Yucel
    Department of Urology, Akdeniz University School of Medicine, Kampus, Antalya, Turkey
    Urology 64:1020-5; discussion 1025. 2004
    ..At least 2% of adults are enuretic during the night. The diagnostic and treatment approach for PNE is empirically the same in children and adults...
  5. ncbi N-ethylmaleimide causes aquaporin-2 trafficking in the renal inner medullary collecting duct by direct activation of protein kinase A
    Stephen Shaw
    School of Biomedical Sciences, Worsley Bldg, Univ of Leeds, Leeds LS2 9NQ, United Kingdom
    Am J Physiol Renal Physiol 288:F832-9. 2005
    ..This effect is not mediated by cAMP but results from direct activation of PKA by NEM...
  6. ncbi Angiotensin II AT1 receptor blockade decreases vasopressin-induced water reabsorption and AQP2 levels in NaCl-restricted rats
    Tae Hwan Kwon
    The Water and Salt Research Ctr, Bldg 233 234, Univ of Aarhus, DK 8000 Aarhus C, Denmark
    Am J Physiol Renal Physiol 288:F673-84. 2005
    ..These results suggest that ANG II AT(1) receptor activation plays a significant role in regulating aquaporin and sodium transporter expression and modulating urine concentration in vivo...
  7. ncbi Bidirectional regulation of AQP2 trafficking and recycling: involvement of AQP2-S256 phosphorylation
    Lene N Nejsum
    The Water and Salt Research Center, University of Aarhus, DK 8000 Aarhus, Denmark
    Am J Physiol Renal Physiol 288:F930-8. 2005
    ....
  8. ncbi Collecting duct-specific knockout of endothelin-1 alters vasopressin regulation of urine osmolality
    Yuqiang Ge
    Division of Nephrology, University of Utah Health Sciences Center, 30 North 1900 East, Salt Lake City, Utah 84132, USA
    Am J Physiol Renal Physiol 288:F912-20. 2005
    ..These data indicate that CD ET-1 KO increases renal sensitivity to the urinary concentrating effects of AVP and suggest that ET-1 functions as a physiological autocrine regulator of AVP action in the CD...
  9. pmc Coupling of vasopressin-induced intracellular Ca2+ mobilization and apical exocytosis in perfused rat kidney collecting duct
    Kay Pong Yip
    Department of Physiology and Biophysics, College of Medicine, University of South Florida, Tampa, FL 33612, USA
    J Physiol 538:891-9. 2002
    ..These results indicate that AVP, via the V2 receptor, triggers a calcium signalling cascade observed as [Ca2+]i oscillations in the IMCD and that intracellular Ca2+ mobilization is required for exocytotic insertion of aquaporin-2...
  10. ncbi Altered expression of COX-1, COX-2, and mPGES in rats with nephrogenic and central diabetes insipidus
    Primoz Kotnik
    The Water and Salt Research Center, University of Aarhus, DK 8000 Aarhus C, Denmark
    Am J Physiol Renal Physiol 288:F1053-68. 2005
    ..These results identify markedly reduced expression of COX-1, COX-2, and mPGES in IM in lithium-induced NDI. Furthermore, there were major changes in the expression of COX-1, COX-2, and mPGES in rats with CDI...
  11. ncbi Desmopressin (DDAVP) for enuresis, diabetes insipidus, and
    Kaye K Gaines
    Bay Pines VA Medical Center, Bay Pines, FL, USA
    Urol Nurs 24:520-3. 2004
  12. ncbi Role of aquaporin-2 gene expression in hyponatremic rats with chronic vasopressin-induced antidiuresis
    T Saito
    Division of Endocrinology and Metabolism, Department of Medicine, Jichi Medical School, Tochigi, Japan
    Kidney Int 60:1266-76. 2001
    ..Either hypervolemia or hypotonicity may diminish the post-receptor signaling of AVP in renal collecting duct cells, under the chronic AVP excess state found in SIADH...
  13. ncbi The evaluation of desmopressin in treatment of adolescent nocturnal enuresis
    Orhan Derman
    Section of Adolescent Medicine, Department of Pediatrics, Hacettepe University School of Medicine, Ankara, Turkey
    Int J Adolesc Med Health 16:377-85. 2004
    ..Desmopressin seems to be effective in the treatment of primary nocturnal enuresis while on therapy but during the long-term follow-up, all cases relapsed...
  14. pmc Vasopressin increases urea permeability in the initial IMCD from diabetic rats
    Vladimir Pech
    Emory Univ School of Medicine, Renal Division, 1639 Pierce Dr, NE, WMB Rm 338, Atlanta, GA 30322, USA
    Am J Physiol Renal Physiol 289:F531-5. 2005
    ..This suggests that the 117-kDa UT-A1 glycoprotein is necessary for vasopressin-stimulated urea transport...
  15. ncbi Vasopressin-V2 receptor stimulation reduces sodium excretion in healthy humans
    Lise Bankir
    INSERM Unité 367, Institut du Fer a Moulin, 17 Rue du Fer a Moulin, 75005 Paris, France
    J Am Soc Nephrol 16:1920-8. 2005
    ..The possibility that an inappropriate stimulation of ENaC by vasopressin might lead to significant sodium retention in chronic situations remains to be determined...
  16. ncbi Bladder capacity and renal concentrating ability in enuresis: pathogenic implications
    T Neveus
    Pediatric Section, Department of Women s and Childrens Health, Uppsala University, Uppsala, Sweden
    J Urol 165:2022-5. 2001
    ..We compared bladder volume and renal concentrating capacity in dry children and 2 distinct groups of children with enuresis to hypothesize about the pathogenesis of various types of enuresis...
  17. ncbi Increased blood pressure, aldosterone activity, and regional differences in renal ENaC protein during vasopressin escape
    Jian Song
    Dept of Medicine, Georgetown University, Box 571412, Washington, DC 20057 1412, USA
    Am J Physiol Renal Physiol 287:F1076-83. 2004
    ..11beta-HSD-2 was increased by dDAVP in the cortex and not significantly affected by water loading. These changes may serve to attenuate Na(+) losses and ameliorate hyponatremia in vasopressin escape...
  18. ncbi cDNA array identification of genes regulated in rat renal medulla in response to vasopressin infusion
    Heddwen L Brooks
    Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Am J Physiol Renal Physiol 284:F218-28. 2003
    ..These studies have identified several transcripts whose abundances are regulated in the inner medulla in response to infusion of dDAVP and that could play roles in the regulation of salt and water excretion...
  19. ncbi An overview of the management of nocturnal enuresis in children
    June Rogers
    Knowsley Primary Care Trust, Manchester
    Br J Nurs 12:898-903. 2003
    ..A child-focused approach will help ensure that whatever treatment is chosen, either the alarm or desmopressin will lead towards the best treatment outcome...
  20. ncbi Proteomic analysis of long-term vasopressin action in the inner medullary collecting duct of the Brattleboro rat
    Bas W M van Balkom
    Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1603, USA
    Am J Physiol Renal Physiol 286:F216-24. 2004
    ....
  21. ncbi Acute regulation of the epithelial sodium channel gene by vasopressin and hyperosmolality
    Kenji Machida
    Department of Nephrology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Hypertens Res 26:629-34. 2003
    ..Determining the physiological significance of the acute effect of vasopressin in MAL will require further investigations...
  22. ncbi Effects of desmopressin on prolonging survival in stable hypothermia in rats
    Tze fun Lee
    Department of Biological Sciences, Biological Science Building, University of Alberta, Edmonton, Alberta T6G 2E9, Canada
    Can J Physiol Pharmacol 81:910-4. 2003
    ..These improvements may have contributed to the observed longer survival time in hypothermia...
  23. ncbi South African guidelines for the management of nocturnal enuresis
    J C van Dyk
    S Afr Med J 93:338-40. 2003
  24. ncbi Role of vasopressin in diabetes mellitus-induced changes in medullary transport proteins involved in urine concentration in Brattleboro rats
    Dongun Kim
    Emory Univ School of Medicine, Renal Division, WMRB Rm 338, 1639 Pierce Drive NE, Atlanta, GA 30322, USA
    Am J Physiol Renal Physiol 286:F760-6. 2004
    ....
  25. ncbi [Stage I-III pulmonary sarcoidosis complicated by nephrogenic (vasopressin-resistant) form of diabetes insipidus]
    K I Volkova
    Klin Med (Mosk) 81:59-64. 2003
    ..Adiurecrine treatment is unefficient. It is recommended to use chlorpropamide which raises sensitivity of the tubules to ADH...
  26. ncbi Perioperative management of diabetes insipidus in children [corrected]
    Lisa Wise-Faberowski
    Children s Hospital Boston and Harvard Medical School, Boston, Massachusetts, USA
    J Neurosurg Anesthesiol 16:14-9. 2004
    ..6 +/- 9.2 mEq/L versus 8.36 +/- 6.43 mEq/L in those children managed by the protocol. Hyponatremia occurred less frequently in the children managed with this protocol compared with historical controls...
  27. ncbi Intermittent oral desmopressin therapy for monosymptomatic primary nocturnal enuresis
    Cem Akbal
    Department of Urology, Hacettepe University Faculty of Medicine, Ankara, Turkey
    J Urol 171:2603-6. 2004
    ..In a prospective study we evaluate the efficacy of intermittent desmopressin (DDAVP) every other day for patients with nocturnal enuresis relapse who need additional therapy...
  28. ncbi [Diabetes insipidus: etiology, diagnosis, and therapy]
    Ferenc Laczi
    Szegedi Tudomanyegyetem, Általános Orvostudományi Kar, Szent Györgyi Albert Orvos és Gyógyszerésztudományi Centrum, Endokrinológiai Onálló Osztály és Kutató Laboratórium
    Orv Hetil 143:2579-85. 2002
    ..Nephrogenic diabetes insipidus can be influenced by non-steroidal antiinflammatory agents or diuretics. Their combined administration is even more effective, however, still does not exceed a 50-percent mitigation in diuresis...
  29. ncbi [Development of formulations of desmopressin intranasal drops]
    Rima Gerbutaviciene
    Kauno medicinos universiteto Vaistu technologijos ir farmacinio darbo organizavimo katedra, Kaunas
    Medicina (Kaunas) 38:545-9. 2002
    ..According to our quality control data, desmopressin intranasal drops are stable for two years and remain sterile during storage and administration of the drug...
  30. ncbi Axial heterogeneity in basolateral AQP2 localization in rat kidney: effect of vasopressin
    Birgitte Mønster Christensen
    The Water and Salt Research Center, Institute of AnatomyUniversity of DK 8000 Aarhus, Denmark
    Am J Physiol Renal Physiol 284:F701-17. 2003
    ..Moreover, acute V(2)-receptor antagonist treatment did not cause retrieval of AQP2 from the BLM. In contrast, long-term dDAVP treatment caused a major increase in AQP2 expression in the BLM in CCD...
  31. ncbi Tackling bedwetting--using the three-systems approach
    Penny Dobson
    Nurs Times 98:58-9. 2002
  32. ncbi [Vasopressin-dependent water permeability of the basolateral membrane of the kidney outer medullary collecting duct in postnatal ontogenesis in rats]
    G S Baturina
    Institute of Cytology and Genetics, Russian Acad Sci, Siberian Branch, 10 Pr Lavrentyeva, Novosibirsk 630090, Russia
    Ross Fiziol Zh Im I M Sechenova 89:605-12. 2003
    ..The mechanism of this decrease remains to be established...
  33. ncbi Perioperative management of diabetes insipidus in children
    Lisa Wise-Faberowski
    Children s Hospital Boston and Harvard Medical School, Boston, Massachusetts, USA
    J Neurosurg Anesthesiol 16:220-5. 2004
    ..6 +/- 9.2 mEq/L versus 8.36 +/- 6.43 mEq/L in those children managed by the protocol. Hyponatremia occurred less frequently in the children managed with this protocol compared with historical controls...
  34. ncbi Chronic dDAVP infusion in rats decreases the expression of P2Y2 receptor in inner medulla and P2Y2 receptor-mediated PGE2 release by IMCD
    Rujia Sun
    Nephrology Research 151M VA Salt Lake City Health Care System, 500 Foothill Dr, Salt Lake City, UT 84148, USA
    Am J Physiol Renal Physiol 289:F768-76. 2005
    ..In conclusion, chronic dDAVP infusion decreases the expression and activity of P2Y2-R in IM. This may be due to a direct effect of dDAVP or dDAVP-induced increase in medullary tonicity...
  35. ncbi Hyponatraemic seizures resulting from inadequate post-operative fluid intake following a single dose of desmopressin
    Zoltan Molnar
    First Department of Pediatrics, Semmelweis University, Budapest, Bókay János u 53, H 1083 Budapest, Hungary
    Nephrol Dial Transplant 20:2265-7. 2005
  36. ncbi Escape from vasopressin-induced antidiuresis: role of vasopressin resistance of the collecting duct
    C A Ecelbarger
    Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892-1603, USA
    Am J Physiol 274:F1161-6. 1998
    ....
  37. ncbi Vasopressin receptor subtype 2 activation increases cell proliferation in the renal medulla of AQP1 null mice
    Qi Cai
    Dept of Physiology, College of Medicine, 1501 N Campbell Ave, Univ of Arizona, Tucson, AZ 85724 5051, USA
    Am J Physiol Renal Physiol 293:F1858-64. 2007
    ..V(2)R activation, via dDAVP, increased AQP2 and AQP3 protein abundance in the cortical collecting ducts of AQP1 null mice. However, V(2)R activation did not increase AQP2 protein abundance in the IMCD of AQP1 null mice...
  38. ncbi Role of prostaglandins in collecting duct-derived endothelin-1 regulation of blood pressure and water excretion
    Yuqiang Ge
    Division of Nephrology, Univ of Utah Health Sciences Center, 900 East 30 North, Salt Lake City, UT 84132, USA
    Am J Physiol Renal Physiol 293:F1805-10. 2007
    ..Furthermore, the increased PGE(2) in CD ET-1 KO mice partly compensates for loss of ET-1 with respect to maintaining urinary water excretion, but not in blood pressure control...
  39. ncbi Effects of urinary ouabain-like factors and vanadium diascorbate on calcium mobilization in porcine inner medullary collecting duct cells: comparison with the effects of ouabain and vasopressin
    H J Kramer
    The Renal Section, Medical Policlinic, University of Bonn, Germany
    Am J Hypertens 11:1208-13. 1998
    ..The physiologic or pathologic roles of these and additional OLF in body fluid and blood pressure regulation and in hypertension have yet to be evaluated...
  40. ncbi Nitric oxide inhibits superoxide-stimulated urea permeability in the rat inner medullary collecting duct
    Joseph Zimpelmann
    Division of Nephrology, The Ottawa Hospital and University of Ottawa, 1967 Riverside Drive, Ottawa, Ontario, Canada K1H 7W9
    Am J Physiol Renal Physiol 285:F1160-7. 2003
    ..In the inner medulla, superoxide generation by local oxidases may stimulate urea transport, and the role of endogenous NO may be to dampen this effect by decreasing superoxide levels...
  41. ncbi Vasopressin regulates apical targeting of aquaporin-2 but not of UT1 urea transporter in renal collecting duct
    T Inoue
    Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda 20892, Maryland, USA
    Am J Physiol 276:F559-66. 1999
    ..Thus vasopressin-mediated regulation of AQP2, but not of VRUT, depends on regulated vesicular trafficking to the plasma membrane...
  42. ncbi [Functional features of actinin and tropomyosin distribution in rat kidney]
    I I Khegai
    Institute of Cytology and Genetics, SD RAS, 630090 Novosibirsk, Lavrentiev av, 10, Russia
    Ross Fiziol Zh Im I M Sechenova 89:1156-60. 2003
    ..This ratio rises up to 46.12 +/- 2.14 versus 13.83 +/- 0.66 (in relative units) for rats being under dehydration that maximally activated vasopressin secretion in normal WAG rats...
  43. ncbi Brain vasopressin and sodium appetite
    Francis W Flynn
    Department of Zoology, University of Wyoming, Laramie, Wyoming 82071, USA
    Am J Physiol Regul Integr Comp Physiol 282:R1236-44. 2002
    ..These findings suggest that the effect of exogenous VP on salt intake is secondary to motor disruptions and that endogenous brain VP neurotransmission acting at V(1) receptors plays a role in the arousal of salt appetite...
  44. ncbi Helping children with nocturnal enuresis: the wait-and-see approach may not be in anyone's best interest
    Amanda K Berry
    Children s Hospital of Philadelphia, USA
    Am J Nurs 106:56-63; quiz 64. 2006
    ..This article offers an overview of the causes and effects of the condition; discusses treatment options, including alarm therapy and medication; and describes ways that nurses can provide education and support...
  45. ncbi Vasopressin-stimulated chloride transport in transimmortalized mouse cell lines derived from the distal convoluted tubule and cortical and inner medullary collecting ducts
    J P Van Huyen
    , , , , Paris, France
    Nephrol Dial Transplant 16:238-45. 2001
    ..I(sc) experiments also suggest the presence of a minor component of electrogenic Cl(-) secretion, possibly mediated by CFTR...
  46. pmc Coordination modes of multidentate ligands in fac-[Re(CO)(3)(polyaminocarboxylate)] analogues of (99m)Tc radiopharmaceuticals. dependence on aqueous solution reaction conditions
    Malgorzata Lipowska
    Department of Radiology, Emory University, Atlanta, Georgia 30322, USA
    Inorg Chem 49:3141-51. 2010
    We study Re analogues of (99m)Tc renal agents to interpret previous results at the (99m)Tc tracer level...
  47. ncbi 99Tcm-cystine, a renal function and imaging agent: a comparative study in dog with 131I-hippurate and 99Tcm-glucoheptonate to evaluate its functional and imaging characteristics
    M Misra
    Department of Nuclear Medicine, Indian Institute of Chemical Biology, Calcutta
    Nucl Med Commun 15:878-85. 1994
    ..Therefore, considering both renal function and imaging properties of 99Tcm-cystine it appears that this radiopharmaceutical offers some definite advantages over the currently available renal agents and commands further study.
  48. ncbi Measurement of the extravascular concentration of renal agents following intravenous bolus injection
    A M Peters
    Department of Diagnostic Radiology, Hammersmith Hospital, London, UK
    Nucl Med Commun 15:66-72. 1994
    The extravascular concentration (Ce) of some renal agents, in relation to the simultaneous plasma concentration (Ci), was calculated as a function of time after intravenous injection...
  49. ncbi Evaluation of 99Tcm-bicisate as a renal imaging agent
    K Ozker
    Division of Nuclear Medicine, Medical College of Wisconsin, Milwaukee 53226, USA
    Nucl Med Commun 18:771-5. 1997
    ..Therefore, we conclude that 99Tcm-ECD is less favourable when compared to existing renal agents due to its high extrarenal uptake and renal kinetics.
  50. ncbi Pediatric uroradiology--1997
    S K Fernbach
    Children s Memorial Hospital, Chicago, IL 60614, USA
    World J Urol 16:46-51. 1998
    ..in the neonate and infants, introduction of newer modalities (Doppler ultrasound), and new nuclear renal agents (Tc-MAG3) have enhanced our ability to detect anomalies and abnormalities...
  51. ncbi Successful conversion from thiazide to tolvaptan in a patient with stage d heart failure and chronic kidney disease before heart transplantation
    Teruhiko Imamura
    Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Int Heart J 54:48-50. 2013
    ..In patients with stage D heart failure, it may be useful to administer tolvaptan with a concomitant reduction in the dose of diuretics in order to preserve renal function and avoid hyponatremia before HTx...
  52. ncbi Ultrasound bladder measurements in patients with primary nocturnal enuresis: a urodynamic and treatment outcome correlation
    C K Yeung
    Department of Surgery, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
    J Urol 171:2589-94. 2004
    ..We evaluate the use of a special ultrasound (US) protocol for the assessment of bladder dysfunction compared with urodynamic findings, and for prediction of treatment outcome in children with primary nocturnal enuresis (PNE)...
  53. ncbi [Responses of the rat kidney to the water load test and vasopressin administered during normal feeding and fasting]
    Jie Gao
    Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Acad Sci, 44 M Thorez Av, St Petersburg, 194223, Russia
    Ross Fiziol Zh Im I M Sechenova 90:202-11. 2004
    ..A problem is discussed of the concept of norm under usual conditions and at certain clinically accepted restrictions, for instance, on empty stomach...
  54. ncbi Altered renal expression of aquaporin water channels and sodium transporters in rats with two-kidney, one-clip hypertension
    Seong Kwon Ma
    Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea
    Kidney Blood Press Res 32:411-20. 2009
    ..To determine whether the renal regulation of aquaporin (AQP) water channels and sodium transporters are altered in 2-kidney, 1-clip (2K1C) hypertension...
  55. ncbi Fluorescent indicators give biased estimates of intracellular free calcium change in aggregating platelets: implication for studies with human von Willebrand factor
    J C Kermode
    Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson 39216, USA
    Blood Cells Mol Dis 22:238-53. 1996
    ..These observations may explain some of the inconsistencies among previous investigations of vWF-induced calcium signaling. Moreover, similar problems may arise in studies with other adhesive proteins...
  56. ncbi Effects of centrally administered arginine vasopressin and atrial natriuretic peptide on the development of brain edema in hyponatremic rats
    Z Vajda
    The Water and Salt Research Center, Institute of Anatomy, University of Aarhus, Denmark
    Neurosurgery 49:697-704; discussion 704-5. 2001
    ..The results emphasize the direct effects of these hormones on the cellular volume regulatory mechanisms in the brain during the development of cerebral edema...
  57. ncbi The next generation of diabetic nephropathy therapies: an update
    Mark E Williams
    Joslin Diabetes Center, Boston, MA 02215, USA
    Adv Chronic Kidney Dis 12:212-22. 2005
    ..To determine whether clinical outcomes (mortality, renal, and cardiovascular events) are improved beyond the current standard of care, phase III trials are planned...
  58. ncbi DNA damage caused by benzo(a)pyrene in MCF-7 cells is increased by verapamil, probenecid and PSC833
    P Myllynen
    Department of Pharmacology and Toxicology, University of Oulu, Oulu, Finland
    Toxicol Lett 169:3-12. 2007
    ....
  59. ncbi Oxytocin microinjected into dorsal motor nucleus of the vagus excites gallbladder motility via NMDA receptor-NO-cGMP pathway
    Chuan Yong Liu
    Institute of Physiology Medical School of Shandong University Jinan 250012 P R China
    Brain Res 1032:116-22. 2005
    ..Hence, we deduced that the microinjection of OT into the DMV enhanced the gallbladder motility through binding specific OT receptors and activating the NMDA receptor-NO-cGMP pathway...
  60. ncbi Long-term durability of the response to desmopressin in female and male nocturia patients
    Kristian Vinter Juul
    Ferring International Pharmascience Center, Copenhagen S, Denmark
    Neurourol Urodyn 32:363-70. 2013
    ..To explore the durability of efficacy and gender differences during chronic administration of desmopressin in nocturia...
  61. ncbi Nitric oxide in the renal medulla protects from vasopressin-induced hypertension
    M Szentivanyi
    Clinical Research Department 2nd Institute of Physiology, Semmelweis University of Medicine, Budapest, Hungary
    Hypertension 35:740-5. 2000
    ....
  62. ncbi Long-term aldosterone treatment induces decreased apical but increased basolateral expression of AQP2 in CCD of rat kidney
    Sophie de Seigneux
    The Water and Salt Research Center, University of Aarhus, DK 8000 Aarhus C, Denmark
    Am J Physiol Renal Physiol 293:F87-99. 2007
    ..The increased basolateral expression of AQP2 induced by aldosterone may play a significant role in water metabolism in conditions with increased sodium reabsorption in the CCD...
  63. ncbi Efficacy of desmopressin in patients with multiple sclerosis suffering from bladder dysfunction: a meta-analysis
    R Bosma
    Department of Health Sciences, Faculty of Medical Sciences, University Medical Center Groningen, Groningen, The Netherlands
    Acta Neurol Scand 112:1-5. 2005
    ..The current review evaluates the safety and efficacy of desmopressin in patients with multiple sclerosis (MS) who suffer from both daytime and nocturnal voiding frequency and from incontinence...
  64. ncbi Protection of chronic renal failure by a polysaccharide from Cordyceps sinensis
    Ying Wang
    School of Life Science and Technology, China Pharmaceutical University, Nanjing, Jiangsu, People s Republic of China
    Fitoterapia 81:397-402. 2010
    ..The changes in blood urea nitrogen and serum creatinine revealed that CPS-2 could significantly relieve renal failure caused by fulgerizing kidney...
  65. ncbi [Infundibulitis, an unusual case of central diabetes insipidus]
    David Gachoud
    Service de Médecine II Hôpital régional, 2900 Porrentruy
    Rev Med Suisse Romande 122:549-51. 2002
    ..Nodular thickening of the pituitary stalk was noted on the MRI and the biopsy permitted a histological diagnosis of infundibulitis...
  66. ncbi Chronic kidney disease: pharmacological considerations for the dentist
    William Brockmann
    University of Missouri Kansas City, 64108, USA
    J Am Dent Assoc 141:1330-9. 2010
    ..Understanding the medical management of renal insufficiency and the pharmacokinetics of common dental drugs will aid clinicians in safely treating these patients...
  67. ncbi Therapy concept in enuretic children
    A Etele-Hainz
    Department of Urology, University of Vienna Medical School, Vienna, Austria
    Eur Urol 33:49-52. 1998
    ....
  68. ncbi Practice parameter for the assessment and treatment of children and adolescents with enuresis
    Gregory Fritz
    J Am Acad Child Adolesc Psychiatry 43:1540-50. 2004
    ..The psychosocial consequences of the symptom must be recognized and addressed with sensitivity during the evaluation and treatment of enuresis...
  69. ncbi Cardiovascular and renal effects of conivaptan hydrochloride (YM087), a vasopressin V1A and V2 receptor antagonist, in dogs with pacing-induced congestive heart failure
    T Yatsu
    Cardiovascular Diseases Research, Pharmacology Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical, Tsukuba, Ibaraki, Japan
    Eur J Pharmacol 376:239-46. 1999
    ..These results indicate that conivaptan produced hemodynamic improvement and marked aquaresis in dogs with congestive heart failure. Therefore, conivaptan may find clinical use in treating patients with congestive heart failure...
  70. ncbi Synthesis and biological evaluation of the four isomers of technetium-99m labeled ethylenecysteamine cysteine ((99m)Tc-ECC), the mono-acid derivative of (99m)tc-L,L-ethylenedicysteine
    H P Vanbilloen
    Laboratory of Radiopharmaceutical Chemistry, K U Leuven, Belgium
    Nucl Med Biol 27:207-14. 2000
    ..However, it is also evident that the configuration at the chiral carbon atom and the orientation of the oxotechnetium core determine in a significant way the biological characteristics...
  71. ncbi The relationship between desmopressin treatment and voiding pattern in children
    G M Hvistendahl
    International Enuresis Research Center, Institute of Experimental Clinical Research, Skejby Hospital, Aarhus, Denmark
    BJU Int 89:917-22. 2002
    ..To collect data on voiding patterns at baseline (no treatment) and during short-term desmopressin treatment, with special reference to the functional and the mean bladder capacity...
  72. ncbi Active lucifer yellow secretion in renal proximal tubule: evidence for organic anion transport system crossover
    R Masereeuw
    Department of Pharmacology, Faculty of Medical Sciences, University of Nijmegen, Nijmegen, The Netherlands
    J Pharmacol Exp Ther 289:1104-11. 1999
    ....
  73. ncbi Treatment of primary monosymptomatic nocturnal enuresis with desmopressin: predictive factors
    S Kruse
    The Urotherapeutic Unit, The Queen Silvia Children s Hospital, Department of Nursing, Goteborg University, Sweden
    BJU Int 88:572-6. 2001
    ..To investigate predictive factors for the outcome of treatment of primary monosymptomatic nocturnal enuresis (PMNE) with desmopressin...
  74. ncbi Cardiovascular and renal developments: patent highlights January to June 2006
    Hermann A M Mucke
    HM Pharma Consultancy, Wien, Austria
    Curr Opin Investig Drugs 7:792-8. 2006
    ..This summary highlights the most interesting developments seen in cardiovascular and renal patents (other than those claiming formulations or combinations of known drugs) published during the first half of 2006...
  75. ncbi Development of Fanconi syndrome during infancy in a patient with cystinosis
    Elena Levtchenko
    Acta Paediatr 95:379-80. 2006
  76. ncbi Long-term outcome of the difficult nephrotic syndrome in children
    Abdullah A Al Salloum
    Pediatric Department, College of Medicine, King Saud University and King Khalid University Hospital, Riyadh, Saudi Arabia
    Saudi J Kidney Dis Transpl 23:965-72. 2012
    ..We suggest longer initial treatment at onset for this group of patients. The low incidence of infection in this group needs to be addressed in future studies...
  77. ncbi Additive antiproteinuric effect of pentoxifylline in patients with type 2 diabetes under angiotensin II receptor blockade: a short-term, randomized, controlled trial
    Juan F Navarro
    Servicio de Nefrologia, Hospital Nuestra Señora de Candelaria, Santa Cruz de Tenerife, Tenerife 38010, Spain
    J Am Soc Nephrol 16:2119-26. 2005
    ..In conclusion, administration of PTF to patients who have type 2 diabetes and are under long-term treatment with an ARB produces a significant additive antiproteinuric effect associated with a reduction of urinary TNF-alpha excretion...
  78. pmc Local renal delivery of a natriuretic peptide a renal-enhancing strategy for B-type natriuretic peptide in overt experimental heart failure
    Horng H Chen
    Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Am Coll Cardiol 53:1302-8. 2009
    ..The purpose of this study was to test the hypothesis that local renal delivery of B-type natriuretic peptide (BNP) will overcome renal resistance to BNP without systemic hypotension...
  79. ncbi Enhanced response to AVP in the interlobular artery from the spontaneously hypertensive rat
    Frank H Hansen
    Renal Research Group, Institute of Medicine, University of Bergen, Bergen, Norway
    Am J Physiol Renal Physiol 288:F1023-31. 2005
    ..The present findings indicate that the exaggerated Ca2+ and contractile response to AVP in SHR is mainly mediated through ILA vasoconstriction...
  80. ncbi Modern approach in treatment of diabetes insipidus
    Elvedina Kapic
    Institute for Pharmacology, Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Sarajevo, Cekalusa 90, 71 000 Sarajevo, Bosnia and Herzegovina
    Bosn J Basic Med Sci 5:38-42. 2005
    ..Antidiuretic effect of desmopressin is the result of agonistic effect on V2 receptors in the renal tubules. The efficacy and safety of desmopressin in mentioned indications was confirmed in clinical studies...
  81. ncbi Use of desmopressin and concomitant use of potentially interacting drugs in elderly patients in Sweden
    Rickard Ljung
    Centre for Epidemiology, The National Board of Health and Welfare, SE 106 30, Stockholm, Sweden
    Eur J Clin Pharmacol 64:439-44. 2008
    ....
  82. ncbi Unexplained polyuria and non-obstructive hydronephrosis in a urological department
    Asher Korzets
    Department of Nephrology, Hillel Yaffe Hospital, Hadera, Israel corrected
    Nephrol Dial Transplant 19:2410-2. 2004
  83. ncbi Increased urinary calcium excretion in enuretic children treated with desmopressin
    Dominik Muller
    Department of Pediatric Nephrology, Charite Children s Hospital, Berlin, Germany
    J Urol 171:2618-20. 2004
    ..However, recent findings have also implicated that desmopressin regulates other molecules, such as sodium and potassium. We investigate if desmopressin influences renal Ca2+ handling...
  84. ncbi Pharmacokinetics of TJ-8117 (Onpi-to), a drug for renal failure (I): Plasma concentration, distribution and excretion of [3H]-(-)epicatechin 3-O-gallate in rats and dogs
    Yukiho Takizawa
    Department of Drug Metabolism and Disposition, Research Division, Tsumura and Co, Inashiki Gun, Ibaraki, Japan
    Eur J Drug Metab Pharmacokinet 29:91-101. 2004
    ..7%, 84.1% and 0.9% of the dose was excreted in urine, feces and expired air, respectively. Data from bile-duct cannulated rats indicated that at least 18.4% of the dose was absorbed...
  85. ncbi Population pharmacokinetics of oseltamivir when coadministered with probenecid
    Craig R Rayner
    F Hoffmann La Roche Ltd, Pharmaceuticals Division, Bldg 015 1 006, CH 4070 Basel, Switzerland
    J Clin Pharmacol 48:935-47. 2008
    ..These factors, set alongside increased capacity for oseltamivir production, should be carefully considered before an oseltamivir-probenecid combination is used...
  86. ncbi Electromotive drug-administration: a pilot study for minimal-invasive treatment of therapy-resistant idiopathic detrusor overactivity
    Peter Bach
    Department of Urology, Klinikum Niederberg Velbert, Academic Hospital, University of Duisburg Essen, Velbert, Germany
    Neurourol Urodyn 28:209-13. 2009
    ..We examined the therapeutic effect of EMDA in patients suffering from therapy-resistant idiopathic detrusor overactivity (IDO) with respect to urodynamics, micturition charts and quality of life (Kings Health Questionnaire)...
  87. ncbi CREB trans-activates the murine H(+)-K(+)-ATPase alpha(2)-subunit gene
    Xiangyang Xu
    Department of Internal Medicine, University of Texas Medical School at Houston, 6431 Fannin Ave, MSB 1 150, Houston, TX 77030, USA
    Am J Physiol Cell Physiol 287:C903-11. 2004
    ..Thus CREB-1, binding to one or more CRE-like elements in the -86/-60 region, trans-activates the HKalpha(2) gene and may represent an important link between rapid and delayed effects of cAMP on HKalpha(2) activity...
  88. ncbi Simple behavioural interventions for nocturnal enuresis in children
    Patrina H Y Caldwell
    Discipline of Paediatrics and Child Health, The Children s Hospital at Westmead Clinical School, University of Sydney, Westmead, Australia
    Cochrane Database Syst Rev 7:CD003637. 2013
    ..Other treatments such as medications, complementary and miscellaneous interventions such as acupuncture, complex behavioural interventions and enuresis alarm therapy are considered elsewhere...
  89. ncbi Vasopressin and oxytocin decrease excitatory amino acid release in adult rat supraoptic nucleus
    M C Currás-Collazo
    Department of Cell Biology and Neuroscience, University of California, Riverside, California, USA
    J Neuroendocrinol 15:182-90. 2003
    ....
  90. ncbi Central diabetes insipidus following carbon monoxide poisoning
    M Y Chang
    Poison Center and Divison of Nephrology, Chang Gung Memorial Hospital, Chang Gung University and Medical College, Taipei, Taiwan
    Am J Nephrol 21:145-9. 2001
    ..These cases illustrate the possibility of central diabetes insipidus and hypernatremia after carbon monoxide poisoning and the importance of immediate antidiuretic hormone treatment and careful fluid therapy...
  91. ncbi Sleep of children with enuresis: a polysomnographic study
    T Neveus
    Department of Pediatrics, Uppsala, Sweden
    Pediatrics 103:1193-7. 1999
    ..To evaluate relationships between bladder voiding and sleep in children with enuresis...
  92. ncbi Agmatine inhibits arginine vasopressin-stimulated urea transport in the rat inner medullary collecting duct
    Alexander J Rouch
    Oklahoma State University Center for Health Sciences, Tulsa, Oklahoma 74107, USA USA
    Kidney Int 62:2101-8. 2002
    ..Dexmedetomidine, a selective alpha2 agonist, does not inhibit AVP-stimulated Pu. This study was conducted to determine if agmatine affects Pu in the rat IMCD and to investigate the possibility of an imidazoline-mediated mechanism...
  93. ncbi Effect of food intake on the pharmacokinetics and antidiuretic activity of oral desmopressin (DDAVP) in hydrated normal subjects
    S Rittig
    Research Laboratory of Nephrology and Hypertension, Aarhus University Hospital, Denmark
    Clin Endocrinol (Oxf) 48:235-41. 1998
    ..The effect of food ingestion on the gastrointestinal absorption and antidiuretic action of oral desmopressin. An oral preparation of desmopressin, a synthetic analogue of vasopressin, has recently become available for clinical use...
  94. pmc Influence of hypernatraemia and urea excretion on the ability to excrete a maximally hypertonic urine in the rat
    Surinder Cheema-Dhadli
    Renal Division, St Michael s Hospital, University of Toronto, Canada M5B 1A6
    J Physiol 541:929-36. 2002
    ..Thus hypernatraemia was the most important factor associated with a higher urine tonicity...
  95. ncbi Managing daytime and night-time enuresis in children
    June Rogers
    Knowsley Primary Care Trust
    Nurs Stand 16:45-52; quiz 54-6. 2002
    ..Children with daytime or night-time enuresis should be assessed to discover the causes, and an appropriate treatment programme should be implemented...
  96. ncbi Stenotic glomerulotubular necks in radiation nephropathy
    E P Cohen
    Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Pathol 190:484-8. 2000
    ....
  97. ncbi Pharmacokinetics and antidiuretic effect of a new vasopressin analogue (F992) in overhydrated male volunteers
    T Callréus
    Department of Clinical Pharmacology, Lund University Hospital, Sweden
    Eur J Clin Pharmacol 55:293-8. 1999
    ....
  98. ncbi Experience with the long-term use of desmopressin for nocturnal enuresis in children and adolescents
    P E V van Kerrebroeck
    Department of Urology, Academic Hospital Maastricht, Maastricht, The Netherlands
    BJU Int 89:420-5. 2002
  99. ncbi ENaC-CFTR interactions: the role of electrical coupling of ion fluxes explored in an epithelial cell model
    Jean Daniel Horisberger
    Institut de Pharmacologie et de Toxicologie, Bugnon 27, 1005 Lausanne, Switzerland
    Pflugers Arch 445:522-8. 2003
    ..Our results show that when ENaC and CFTR are expressed in the same apical membrane, the electrical coupling of these two ion channels can explain at least part of the effect of CFTR activation on the Na(+) current flowing through ENaC...
  100. ncbi Prophylactic efficacy of desmopressin acetate for diabetes insipidus after hypophysectomy in the dog
    Yasushi Hara
    Division of Veterinary Surgery, Nippon Veterinary and Animal Science University, Tokyo, Japan
    J Vet Med Sci 65:17-22. 2003
    ....
  101. ncbi An integrative physiological approach to polyuria and hyponatraemia: a 'double-take' on the diagnosis and therapy in a patient with schizophrenia
    Y Edoute
    Department of Internal Medicine C, Rambam Medical Center, Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    QJM 96:531-40. 2003
    ..Applying this simple approach, a more comprehensive and accurate differential diagnosis, and a plan for therapy to avoid serious complications was compiled...

Research Grants8

  1. Ginkgo biloba for ECT-induced Memory Deficits
    JOHN MARKOWITZ; Fiscal Year: 2003
    ..will utilize larger groups and additional cognitive tests will be incorporated to provide more definitive conclusions regarding efficacy, optimal dose and duration, persistence of effects, and safety and tolerability ..
  2. P-Glycoprotein and Disposition of Psychostimulants
    JOHN MARKOWITZ; Fiscal Year: 2005
    ....
  3. Sgk1 in Na+ transport in fetal lung epithelia
    Christie Thomas; Fiscal Year: 2007
    ..abstract_text> ..
  4. NEUROPEPTIDES AND SALT APPETITE
    FRANCIS FLYNN; Fiscal Year: 2007
    ..Successful completion of the proposed work will expand the knowledge base on brain mechanisms controlling bodily fluid homeostasis. ..
  5. Neuroscience Center for Biomedical Research Excellence
    Francis W Flynn; Fiscal Year: 2010
    ....
  6. Screening Herbs for Drug Interactions
    JOHN MARKOWITZ; Fiscal Year: 2002
    ..Further, the proposed studies will complement existing and future NCCAM studies of agents such as St. John's wort and Gingko biloba. ..
  7. REGULATION AND FUNCTION OF THE ALPHA SUBUNIT OF ENAC
    Christie Thomas; Fiscal Year: 2003
    ..The long-term objectives are to understand the regulation and function of ENaC in transepithelial Na+ transport. ..