Summary: Substances that can carry oxygen to and carbon dioxide away from the tissues when introduced into the blood stream. They are used to replace hemoglobin in severe hemorrhage and also to perfuse isolated organs. The best known are perfluorocarbon emulsions and various hemoglobin solutions.
Publications259 found, 100 shown here
- Effects of recombinant-hemoglobin solutions rHb2.0 and rHb1.1 on blood pressure, intestinal blood flow, and gut oxygenation in a rat model of hemorrhagic shockNicolaas J H Raat
Department of Physiology, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
J Lab Clin Med 145:21-32. 2005..0, the effect of rHb2.0 on pH, base-excess and microvascular Po2 levels after resuscitation were comparable to those achieved with the use of the albumin solution...
- Bone-forming capacity of mesenchymal stromal cells when cultured in the presence of human platelet lysate as substitute for fetal bovine serumHenk Jan Prins
Department of Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
Tissue Eng Part A 15:3741-51. 2009..These results warrant the use of PL for ex vivo expansion of human MSCs for bone tissue engineering applications...
- First-generation blood substitutes: what have we learned? Biochemical and physiological perspectivesAbdu I Alayash
Center for Biologics Evaluation and Research, Food and Drug Administration, Laboratory of Biochemistry and Vascular Biology, Division of Hematology, National Institutes of Health Campus, Bethesda, MD 20892, USA
Expert Opin Biol Ther 7:665-75. 2007..or recombinant hemoglobin (Hb)-based oxygen carriers (HBOCs) have been developed as oxygen therapeutics or 'blood substitutes' for use in a variety of clinical settings...
- Blood substitutes. Artificial oxygen carriers: perfluorocarbon emulsionsD R Spahn
Institut für Anästhesiologie, Universitatsspital, Zurich, Switzerland
Crit Care 3:R93-7. 1999....
- Fluorinated materials for in vivo oxygen transport (blood substitutes), diagnosis and drug deliveryJ G Riess
MRI Institute, Medical Center, University of California, San Diego 92103 1990, USA
Biomaterials 19:1529-39. 1998..Fluorinated amphiphiles also allowed the obtaining of a variety of stable reverse and multiple emulsions and gels. These systems are being investigated as drug delivery devices...
- Blood substitutes. Haemoglobin therapeutics in clinical practiceJ F Baron
Hopital Broussais, Paris, France
Crit Care 3:R99-102. 1999....
- Tyrosine residues as redox cofactors in human hemoglobin: implications for engineering nontoxic blood substitutesBrandon J Reeder
Department of Biological Sciences, University of Essex, Wivenhoe Park, Colchester, Essex CO4 3SQ, UK
J Biol Chem 283:30780-7. 2008..Ferryl iron has been suggested to be a major cause of the oxidative toxicity of hemoglobin-based blood substitutes. Engineering hemoglobin with enhanced rates of ferryl removal, as we show here, is therefore likely to ..
- In vitro macrophage uptake and in vivo biodistribution of PLA-PEG nanoparticles loaded with hemoglobin as blood substitutes: effect of PEG contentYan Sheng
The State Key Laboratory of Bioreactor Engineering, Engineering Research Center for Biomedical Materials of Ministry of Education, East China University of Science and Technology, Mailbox 112, 130 Meilong Road, Xuhui District, Shanghai, 200237, People s Republic of China
J Mater Sci Mater Med 20:1881-91. 2009..of poly(lactic acid) (PLA)-poly(ethylene glycol) (PEG) hemoglobin (Hb)-loaded nanoparticles (HbP) used as blood substitutes. The HbP were prepared from PLA and PLA-PEG copolymer of varying PEG contents (5, 10, and 20 wt%) by a ..
- Setbacks in blood substitutes research and development: a biochemical perspectiveAbdu I Alayash
Division of Hematology, Laboratory of Biochemistry and Vascular Biology, Center for Biologics Evaluation and Research, Food and Drug Administration PHS, 8800 Rockville Pike, Bethesda, MD 20892, USA
Clin Lab Med 30:381-9. 2010Recent setbacks in using Hb-based technology to develop oxygen carriers or blood substitutes may spur new and fundamentally different approaches for the development of a new generation of hemoglobin-based oxygen carriers (HBOCs)...
- HBOC-201 as an alternative to blood transfusion: efficacy and safety evaluation in a multicenter phase III trial in elective orthopedic surgeryJonathan S Jahr
David Geffen School of Medicine at UCLA, Los Angeles, California, USA
J Trauma 64:1484-97. 2008..The ability of hemoglobin based oxygen carrier-201 (HBOC-201) to safely reduce and/or eliminate perioperative transfusion was studied in orthopedic surgery patients...
- Low-volume fluid resuscitation for presumed hemorrhagic shock: helpful or harmful?S A Stern
Department of Emergency Medicine, University of Michigan, Ann Arbor, Michigan 48109 0303, USA
Curr Opin Crit Care 7:422-30. 2001..Future research should focus on developing resuscitation methods that may actually enhance tissue perfusion during limited resuscitation and therefore offset its potential detrimental effects...
- Resuscitation from hemorrhagic shock with HBOC-201 in the setting of traumatic brain injuryJeffrey D Kerby
Department of Surgery, Section of Trauma Burns and Surgical Critical Care, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
Shock 27:652-6. 2007..These results suggest that resuscitation with HBOC-201 protects autoregulatory mechanisms and may reduce secondary brain injury in traumatic brain injury...
- DCL-Hb for trauma patients with severe hemorrhagic shock: the European "On-Scene" multicenter studyThoralf Kerner
Klinik fur Anasthesiologie und Operative Intensivmedizin, Campus Virchow Klinikum, Charite, Humboldt Universitat, Augustenburger Platz 1, 13353 Berlin, Germany
Intensive Care Med 29:378-85. 2003..Early administration of an oxygen carrier may reduce the occurrence of organ failures and improve survival. It may also reduce the need of blood products...
- Molecular aspects of the high oxygen affinity of non-hypertensive hexa pegylated hemoglobin, [(SP-PEG5K)(6)-Hb]Dongxia Li
Department of Physiology, Albert Einstein College of Medicine, Bronx, NY, USA
Artif Cells Blood Substit Immobil Biotechnol 35:19-29. 2007....
- Model of nitric oxide diffusion in an arteriole: impact of hemoglobin-based blood substitutesMahendra Kavdia
Department of Biomedical Engineering and Center for Computational Medicine and Biology, School of Medicine, The Johns Hopkins University, Baltimore, Maryland 21205, USA
Am J Physiol Heart Circ Physiol 282:H2245-53. 2002..The SM NO concentration was significantly reduced when the extravasation of HBOC molecules was considered. The myoglobin present in the parenchymal cells scavenges NO, which reduces the SM NO concentration...
- Recombinant hemoglobins as artificial oxygen carriersClara Fronticelli
Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Artif Cells Blood Substit Immobil Biotechnol 35:45-52. 2007....
- Hb(alphaalpha,betabeta): a novel fusion construct for a dimeric, four-domain hemoglobinGianna Panetta
Dipartimento di Scienze Biochimiche A Rossi Fanelli, Universita di Roma Sapienza, Piazzale A Moro 5 00185 Roma, Italy
Biochim Biophys Acta 1784:1462-70. 2008Hemoglobin-based blood substitutes are one of the options available to derive a resuscitating fluid taking into account clinical and physiological demands...
- Use of hemoglobin-based oxygen-carrying solution-201 to improve resuscitation parameters and prevent secondary brain injury in a swine model of traumatic brain injury and hemorrhage: laboratory investigationGuy Rosenthal
Department of Neurosurgery, University of California, San Francisco, CA 94117, USA
J Neurosurg 108:575-87. 2008..We studied the effects of hemoglobin-based oxygen-carrying (HBOC)-201 solution compared with lactated Ringer (LR) solution in a large animal model of brain injury and hemorrhage, in a blinded prospective randomized study...
- Towards a novel haemoglobin-based oxygen carrier: Euro-PEG-Hb, physico-chemical properties, vasoactivity and renal filtrationI Portöro
Institute of Human Physiology and Clinical Experimental Research, Faculty of Medicine, Semmelweis University, Budapest, Hungary
Biochim Biophys Acta 1784:1402-9. 2008....
- Cell-free oxygen carriers: scientific foundations, clinical development, and new directionsRobert M Winslow
Sangart Inc, San Diego, California, USA
Biochim Biophys Acta 1784:1382-6. 2008..Because of its low P50 and increased molecular size, the release of O2 in resistance vessels (arterioles) by Hemospan is restricted, and vasoconstriction is greatly reduced...
- A recombinant polymeric hemoglobin with conformational, functional, and physiological characteristics of an in vivo O2 transporterKevin M Bobofchak
Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, 600 N Wolfe St, Baltimore, MD 21287, USA
Am J Physiol Heart Circ Physiol 285:H549-61. 2003..Polymerization maintains physiologically relevant oxygen and heme affinity, stability toward denaturation and oxidation, and effective oxygen delivery as indicated by reduced cerebral ischemic damage...
- Ligand reactivity and allosteric regulation of hemoglobin-based oxygen carriersLuca Ronda
Department of Biochemistry and Molecular Biology, University of Parma, Parma, Italy
Biochim Biophys Acta 1784:1365-77. 2008....
- Design of recombinant hemoglobins for use in transfusion fluidsClara Fronticelli
Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University School of Medicine, Blalock, Baltimore, MD 21287, USA
Crit Care Clin 25:357-71, Table of Contents. 2009..These polymers of recombinant hemoglobin have the characteristics of molecular size, molecular stability, and oxygen delivery to hypoxic tissue suitable for an HBOC...
- Liposome-encapsulated actin-hemoglobin (LEAcHb) artificial blood substitutesShuliang Li
Department of Chemical and Biomolecular Engineering, University of Notre Dame, 171 Fitzpatrick Hall, Notre Dame, IN 46556, USA
Biomaterials 26:3759-69. 2005..has been applied to develop liposome-encapsulated actin-hemoglobin (LEAcHb) dispersions as potential blood substitutes by introducing an actin matrix into the liposome aqueous core...
- The risks of blood transfusions and the shortage of supply leads to the quest for blood substitutesNicole Soraya Nouwairi
Virginia Commonwealth University, Department of Nurse Anesthesia, Richmond, USA
AANA J 72:359-64. 2004A number of factors have combined to drive the interest in developing blood substitutes. These include the time-dependent decrement in stored blood biochemistry, the general shortage of the blood supply, and public awareness of the risks ..
- PEGylation promotes hemoglobin tetramer dissociationDario Caccia
Dipartimento di Scienze e Tecnologie Biomediche, Dipartimento di Chimica, Biochimica e Biotecnologie per la Medicina, Universita degli Studi di Milano, Milano, Italy
Bioconjug Chem 20:1356-66. 2009..These features are more pronounced for PEG-Hb(oxy) than PEG-Hb(deoxy). The detected heterogeneity might be a source of adverse effects when PEGylated Hbs are used as blood substitutes.
- A review of blood substitutes: examining the history, clinical trial results, and ethics of hemoglobin-based oxygen carriersJiin Yu Chen
Anesthesiology, University of Texas Medical Branch, Galveston, TX, USA
Clinics (Sao Paulo) 64:803-13. 2009..Thus, the available evidence suggests that HemAssist, Polyheme, and Hemopure are associated with a significant level of cardiovascular dysfunction. The next generation of HBOCs remains under development...
- Electrophoretic analysis of PEGylated hemoglobin-based blood substitutesLuca Ronda
Dipartimento di Biochimica e Biologia Molecolare, Universita degli Studi di Parma, Italy
Anal Biochem 408:118-23. 2011Polyethylene glycol (PEG)-conjugated hemoglobins, a novel class of blood substitutes, were investigated by a combination of native and denaturing one- and two-dimensional polyacrylamide gel electrophoresis (PAGE) coupled with the ..
- Modulation of expression and polymerization of hemoglobin Polytaur, a potential blood substituteSerena Faggiano
Department of Biochemistry and Molecular Biology, University of Parma, Parma, Italy
Arch Biochem Biophys 505:42-7. 2011....
- Insights from studies of blood substitutes in traumaErnest E Moore
Department of Surgery, Denver Health Medical Center and University of Colorado Health Sciences Center, Denver, Colorado 80204, USA
Shock 24:197-205. 2005Most authorities believe that the greatest need for blood substitutes is in patients with unanticipated acute blood loss, and trauma is the most likely scenario...
- A prospective trial of diaspirin cross-linked hemoglobin solution in patients after elective repair of abdominal aortic aneurysmEric L Bloomfield
Division of Anesthesiology and Critical Care Medicine, Cleveland Clinic Foundation, Cleveland, OH, USA
Mil Med 169:546-50. 2004..However, its use may lead to decreases in cardiac output because of increases in afterload, which may pose serious problems with left ventricular function...
- Resuscitation from severe hemorrhagic shock after traumatic brain injury using saline, shed blood, or a blood substituteJeffrey B Gibson
Department of Surgery, University of Tennessee Health Science Center, Memphis 38163, USA
Shock 17:234-44. 2002..Further investigations in similar experimental models might provide some plausible explanations why DCLHb unexpectedly increased mortality in patients...
- The clinical trials of diaspirin cross-linked hemoglobin (DCLHb) in severe traumatic hemorrhagic shock: the tale of two continentsEdward P Sloan
Intensive Care Med 29:347-9. 2003
- The use of bovine hemoglobin glutamer-250 (Hemopure) in surgical patients: results of a multicenter, randomized, single-blinded trialJuraj Sprung
Department of Anesthesiology and Vascular Surgery, The Cleveland Clinic Foundation, Cleveland, Ohio, USA
Anesth Analg 94:799-808, table of contents. 2002..The administration of HBOC-201 was associated with a delayed (third postoperative day) dose-dependent increase in the plasma methemoglobin concentration. We conclude that the intraoperative use of HBOC-201 was generally well tolerated...
- Diaspirin-crosslinked hemoglobin reduces blood transfusion in noncardiac surgery: a multicenter, randomized, controlled, double-blinded trialArmin Schubert
Department of General Anesthesiology, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
Anesth Analg 97:323-32, table of contents. 2003..Whereas the side-effect profile of modified hemoglobin solutions needs to be improved, our data show that hemoglobin solutions can be effective at reducing exposure to allogeneic blood for elective surgery...
- Recommendations on the use of recombinant activated factor VII as an adjunctive treatment for massive bleeding--a European perspectiveJean Louis Vincent
Department of Intensive Care, Erasme Hospital, Free University of Brussels, B 1070 Brussels, Belgium
Crit Care 10:R120. 2006..Our aim was to develop consensus guidelines for use of recombinant activated factor VII (rFVIIa) in massive hemorrhage...
- Current status of oxygen carriers ('blood substitutes'): 2006R M Winslow
Sangart, Inc, San Diego, USA
Vox Sang 91:102-10. 2006..Such products may seem counterintuitive by traditional standards, but it is hoped that they will be less toxic, more beneficial to patients, and more economical to produce...
- The life-sustaining capacity of human polymerized hemoglobin when red cells might be unavailableSteven A Gould
Northfield Laboratories Inc, Evanston, IL, USA
J Am Coll Surg 195:445-52; discussion 452-5. 2002..PolyHeme should be particularly useful when red cells may be temporarily unavailable. This article assesses survival at life-threatening RBC hemoglobin concentration ([Hb]) in massively bleeding patients who do not receive red cells...
- Salvage of focal cerebral ischemic damage by transfusion of high O2-affinity recombinant hemoglobin polymers in mouseMasaaki Nemoto
Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
J Appl Physiol 100:1688-91. 2006..The assumption that the P50 of blood substitutes should be similar to that of blood might not be warranted when used during ischemic conditions.
- Choice of fluid influences outcome in prolonged hypotensive resuscitation after hemorrhage in awake ratsMichael T Handrigan
Division of Military Casualty Research, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, USA
Shock 23:337-43. 2005..4x EBV), survival was no better than C and it resulted in the most significant acidosis. These results support the decision to use Hextend for Hypo, a strategy currently being applied on the battlefield...
- Present status of modified hemoglobin as blood substitutes and oral therapy for end stage renal failure using artificial cells containing genetically engineered cellsT M Chang
Faculty of Medicine, McGill University, Montreal, Quebec, Canada
Ann N Y Acad Sci 944:362-72. 2001Artificial cell or bioencapsulation has been developed for use in bioartificial organs, drug delivery, blood substitutes, and other areas...
- Prehospital HBOC-201 after traumatic brain injury and hemorrhagic shock in swineMayur B Patel
Division of Trauma, DeWitt Daughtry Family Department of Surgery, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
J Trauma 61:46-56. 2006..This study evaluates neurotoxicity, vasoactivity, cardiac toxicity, and inflammatory activity of HBOC-201 (Biopure, Cambridge, Mass.) resuscitation in a TBI model...
- Cell-free hemoglobin-based blood substitutes and risk of myocardial infarction and death: a meta-analysisCharles Natanson
Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, Maryland 20892, USA
JAMA 299:2304-12. 2008Hemoglobin-based blood substitutes (HBBSs) are infusible oxygen-carrying liquids that have long shelf lives, have no need for refrigeration or cross-matching, and are ideal for treating hemorrhagic shock in remote settings...
- Resuscitation with the hemoglobin-based oxygen carrier, HBOC-201, in a swine model of severe uncontrolled hemorrhage and traumatic brain injurySusan Stern
Department of Emergency Medicine, University of Michigan, Ann Arbor, Michigan 48109 0303, USA
Shock 31:64-79. 2009....
- Biochemical aspects of the reaction of hemoglobin and NO: implications for Hb-based blood substitutesR P Patel
Center for Free Radical Biology and Department of Pathology, Molecular and Cellular Division, University of Alabama at Birmingham, Birmingham, AL 35294 0019, USA
Free Radic Biol Med 28:1518-25. 2000..This can occur during hemolysis or administration of Hb-based blood substitutes. Scavenging of NO is a significant problem that limits the use of Hb-based blood substitutes in the clinic, ..
- Blood conservation strategies to reduce the need for red blood cell transfusion in critically ill patientsAlan T Tinmouth
University of Ottawa Centre for Transfusion Research, Ottawa Health Research Institute, Ottawa, Ont
CMAJ 178:49-57. 2008..Further research is needed to determine the potential roles for other blood conservation strategies...
- Controlled safety study of a hemoglobin-based oxygen carrier, DCLHb, in acute ischemic strokeR Saxena
Department of Neurology, University Hospital Dijkzigt, Rotterdam, The Netherlands
Stroke 30:993-6. 1999..In animal stroke models its use led to a significant reduction in the extent of brain injury. The primary objective of this study was to evaluate the safety of DCLHb in patients with acute ischemic stroke...
- Hemoglobin-based oxygen carrying compound-201 as salvage therapy for severe neuro- and polytrauma (Injury Severity Score = 27-41)Michael Dudkiewicz
DeWitt Daughtry Family Department of Surgery, Division of Trauma, University of Miami Miller School of Medicine, Miami, FL, USA
Crit Care Med 36:2838-48. 2008..We tested the hypothesis that HBOC-201 would improve cerebrovascular resuscitation in a unique polytrauma model...
- Diaspirin cross-linked hemoglobin (DCLHb) in the treatment of severe traumatic hemorrhagic shock: a randomized controlled efficacy trialE P Sloan
Department of Emergency Medicine, University of Illinois at Chicago, 60612, USA
JAMA 282:1857-64. 1999..Severe, uncompensated, traumatic hemorrhagic shock causes significant morbidity and mortality, but resuscitation with an oxygen-carrying fluid might improve patient outcomes...
- Randomized trial of diaspirin cross-linked hemoglobin solution as an alternative to blood transfusion after cardiac surgery. The DCLHb Cardiac Surgery Trial Collaborative GroupM L Lamy
Department of Anesthesia and Intensive Care Medicine of the University of Liège, Centre Hospitalier Universitaire, Belgium
Anesthesiology 92:646-56. 2000..New oxygen-carrying compounds such as diaspirin cross-linked hemoglobin (DCLHb) could enable more patients to avoid allogeneic blood transfusion...
- Perflubron emulsion delays blood transfusions in orthopedic surgery. European Perflubron Emulsion Study GroupD R Spahn
Department of Anesthesiology, University Hospital Zurich, Switzerland
Anesthesiology 91:1195-208. 1999..The aim of the present study is to compare the effectiveness of perflubron emulsion with the effectiveness of autologous blood or colloid infusion for reversal of physiologic transfusion triggers...
- An open letter to institutional review boards considering Northfield Laboratories' PolyHeme trialKen Kipnis
University of Hawaii, Manoa, USA
Am J Bioeth 6:18-21. 2006..Blood-the standard treatment for hemorrhagic shock-is not available in ambulances but is available in hospitals. The authors argue that the in-hospital stage of the study fails to meet ethical and regulatory standards...
- A human recombinant haemoglobin designed for use as a blood substituteD Looker
Somatogen Inc, Boulder, Colorado 80301
Nature 356:258-60. 1992..Fusion of the two alpha-globin subunits increases the half-life of this haemoglobin molecule in vivo by preventing its dissociation into alpha beta dimers and therefore also eliminates renal toxicity...
- Determination of size distribution and encapsulation efficiency of liposome-encapsulated hemoglobin blood substitutes using asymmetric flow field-flow fractionation coupled with multi-angle static light scatteringDian R Arifin
Department of Chemical and Biomolecular Engineering, Center for Molecularly Engineered Materials, University of Notre Dame, Notre Dame, Indiana 46556, USA
Biotechnol Prog 19:1798-811. 2003..25 mmHg and 2.49. These oxygen-binding properties indicate that LEHbs possess strong potential as artificial blood substitutes. In addition, the metHb levels in PB-LEHb dispersions are significantly low even in the absence of ..
- Hemoglobin-based blood substitutes: oxygen carriers, pressor agents, or oxidants?A I Alayash
Laboratory of Plasma Derivatives, Center for Biologics Evaluation and Research, Food and Drug Administration, NIH Campus, Bethesda, MD 20892, USA
Nat Biotechnol 17:545-9. 1999Hemoglobin-based blood substitutes are being developed as oxygen-carrying agents for the prevention of ischemic tissue damage and hypovolemic (low blood volume) shock...
- Hemoglobin-based blood substitutes and the hazards of blood radicalsA I Alayash
Laboratory of Plasma Derivatives, Center for Biologics Evaluation and Research, Food and Drug Administration, National Institutes of Health Campus, Bethesda, Maryland 20892, USA
Free Radic Res 33:341-8. 2000..This article reviews our current understanding of heme-mediated toxicities and some of the emerging protective strategies used to overcome hemoglobin side reactions...
- The future of clinical trials evaluating blood substitutesDean A Fergusson
JAMA 299:2324-6. 2008
- No scavenging and the hypertensive effect of hemoglobin-based blood substitutesJohn S Olson
Department of Biochemistry and Cell Biology, W M Keck Center for Computational Biology, Rice University, Houston, TX 77005, USA
Free Radic Biol Med 36:685-97. 2004..vasoconstrictive, and the resultant hypertension is a significant side effect of most hemoglobin-based blood substitutes. The major cause of this blood pressure effect seems to be the high rate of NO dioxygenation by cell-free ..
- Human polymerized hemoglobin for the treatment of hemorrhagic shock when blood is unavailable: the USA multicenter trialErnest E Moore
Department of Surgery, Denver Health Medical Center, University of Colorado, Denver, CO, USA
J Am Coll Surg 208:1-13. 2009..This multicenter phase III trial was the first US study to assess survival of patients resuscitated with a hemoglobin-based oxygen carrier starting at the scene of injury...
- Cardiovascular and coronary physiology of acute isovolemic hemodilution: a review of nonoxygen-carrying and oxygen-carrying solutionsD R Spahn
Institut für Anästhesiologie, Universitatsspital Zurich, Switzerland
Anesth Analg 78:1000-21. 1994..However, with enhanced purification, chemical modification or microencapsulation of the hemoglobin molecule, vasoconstriction can be limited...
- Physiological properties of blood substitutesD R Spahn
, , , , Switzerland
News Physiol Sci 16:38-41. 2001b>Blood substitutes (modified hemoglobin solutions, perfluorocarbon emulsions) serve as artificial oxygen carriers and are alternatives to blood transfusions...
- Blood substitutes: where do we stand today?B T Kjellstrom
Experimental Traumatology Unit, Swedish Defence Research Agency and Department of Surgery, Karolinska Institute at Soder Hospital, Stockholm, Sweden
J Intern Med 253:495-7. 2003
- Blood substitutes as pharmacotherapies in clinical practiceJonathan S Jahr
Department of Anesthesiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
Curr Opin Anaesthesiol 20:325-30. 2007To discuss the development and current status of blood substitutes, including hemoglobin-based oxygen carriers (HBOCs) and perfluorocarbons...
- Hb-based oxygen carriers: are we there yet?Thomas J Reid
Department of Blood Research, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, USA
Transfusion 43:280-7. 2003
- Blood substitutes: the future is nowErnest E Moore
Department of Surgery, Denver Health Medical Center and University of Colorado Health Sciences Center, Denver, CO 80204, USA
J Am Coll Surg 196:1-17. 2003
- Blood substitutes and experimental models of traumaKenneth G Proctor
Daughtry Family Department of Surgery, University of Miami School of Medicine, Florida 33106, USA
J Trauma 54:S106-9. 2003
- Blood substitutes based on nanobiotechnologyThomas Ming Swi Chang
Department of Physiology, Faculty of Medicine, McGill University, 3655 Drummond Street, Montreal, Quebec, H3G 1Y6, Canada
Trends Biotechnol 24:372-7. 2006..by concerns of potential infective agents in donated blood, commercial enterprises have attempted to develop blood substitutes since the 1900s. After several years of development, a few of the many leads are showing promise...
- Blood substitutes and oxygen therapeutics: an overview and current statusJonathan S Jahr
Department of Anesthesiology, University of California at Los Angeles, Los Angeles, CA 90095 1778, USA
Am J Ther 9:437-43. 2002This review article discusses the development and implementation of a number of blood substitutes, including hemoglobin-based oxygen carriers (HBOCs) and perfluorocarbons...
- Modified hemoglobin-based blood substitutes: crosslinked, recombinant and encapsulated hemoglobinT M Chang
Artificial Cells and Organs Research Centre, Faculty of Medicine, McGill University, Montreal, Quebec, Canada
Vox Sang 74:233-41. 1998..A third generation hemoglobin-based blood substitute is based on microencapsulated hemoglobin, artificial red blood cells, that more closely resemble a complete red blood cell...
- A hemoglobin based oxygen carrier, bovine polymerized hemoglobin (HBOC-201) versus Hetastarch (HEX) in an uncontrolled liver injury hemorrhagic shock swine model with delayed evacuationJennifer Gurney
Walter Reed Army Medical Center J G, Washington, DC, USA
J Trauma 57:726-38. 2004..As HBOC-201 improves outcome in animals with hemorrhagic shock (HS), we compared HBOC-201 and HEX (used by U.S. military special operations forces) in a swine model of delayed evacuation and uncontrolled HS...
- Artificial oxygen carriers as red blood cell substitutes: a selected review and current statusHae won Kim
Department of Surgery, Brown University Medical School, The Miriam Hospital, Providence, RI 02906, USA
Artif Organs 28:813-28. 2004..This article provides a short review of the basic principles, approaches, and current status of RCS development. Results of preclinical and clinical studies including recent Phase II/III clinical studies are discussed...
- Overcoming blood shortages: red blood cell and platelet substitutes and membrane modificationsRichard J Davey
New York Blood Center, 310 East 67th Street, New York, NY 10021, USA
Curr Hematol Rep 3:92-6. 2004..However, these new products will be a useful alternative for selected clinical applications and will lessen our dependence on our marginally adequate blood supply...
- Is hemoglobin in hemoglobin vesicles infused for isovolemic hemodilution necessary to improve oxygenation in critically ischemic hamster skin?Jan A Plock
Department of Orthopedic, Plastic and Hand Surgery, Inselspital Univ Hospital, CH 3010 Berne, Switzerland
Am J Physiol Heart Circ Physiol 289:H2624-31. 2005..01). We conclude that the encapsulation of Hb was essential to attenuate hypoxia and subsequent cell death in the critically ischemic tissue. However, the effect was partly attributed to the rheological changes exerted by the vesicles...
- A hemoglobin-based oxygen carrier, bovine polymerized hemoglobin (HBOC-201) versus hetastarch (HEX) in a moderate severity hemorrhagic shock swine model with delayed evacuationNora Philbin
Naval Medical Research Center, Combat Casualty Care, 2N77 503 Robert Grant Avenue, Silver Spring, MD 20910, USA
Resuscitation 66:367-78. 2005..To evaluate the efficacy of HBOC-201 for resuscitation of hemorrhagic shock in a swine model incorporating soft tissue injury and delayed evacuation...
- Chemically modified porcine hemoglobins and their biological propertiesCai Jin
College of Material and Chemical Engineering, Zhejiang University, Hangzhou 310027, China
Protein Pept Lett 11:353-60. 2004..Somewhat beneficial effects were shown in the treatment of hemorrhagic shock where modified hemoglobin solutions were used as resuscitation fluids in the hemorrhagic shock Sprague-Dawley (SD) rats model...
- [Current aspects in red blood cell substitutes]Yanfeng Wang
The Key Laboratory of Bioactive Materials, Nankai University, Ministry of Education, Tianjin 300071, China
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 21:490-4. 2004..When they are available for use it is likely that development will accelerate and even better products will substantially alleviate the world-wide shortage of blood for transfusion...
- The next generation in shock resuscitationFrederick A Moore
Department of Surgery, University of Texas Houston Medical School, Houston, TX 77030, USA
Lancet 363:1988-96. 2004....
- Quantification of cerebral hemoglobin as a function of oxygenation using near-infrared time-resolved spectroscopy in a piglet model of hypoxiaSonoko Ijichi
Kagawa University, Department of Pediatrics, Faculty of Medicine, Mikicho 1750 1, Kitagun, Kagawa 761 0793, Japan
J Biomed Opt 10:024026. 2005..Therefore, abs of the head with BET by FC is more useful for estimation of the absolute values of oxyHb and deoxyHb of the piglet head...
- New generation of hemoglobin-based oxygen carriers evaluated for oxygenation of critically ischemic hamster flap tissueClaudio Contaldo
Department of Orthopedic, Plastic, and Hand Surgery, Inselspital University Hospital, Berne, Switzerland
Crit Care Med 33:806-12. 2005....
- Update on alternative oxygen carriersJ R Hess
University of Maryland School of Medicine, Baltimore 21201, USA
Vox Sang 87:132-5. 2004
- A bloodless revolution. A growing interest in artificial blood substitutes has resulted in new products that could soon improve transfusion medicineAndrea Rinaldi
EMBO Rep 6:705-8. 2005
- Prehospital hemoglobin-based oxygen carrier resuscitation attenuates postinjury acute lung injuryTomohiko Masuno
Department of Surgery, Denver Health Medical Center, CO 80204, USA
Surgery 138:335-41. 2005..The purpose of this in vivo study is to simulate an existing multicenter prehospital trial of HBOC versus crystalloid to determine the effects in a controlled 2-event construct of postinjury multiple organ failure...
- Acellular haemoglobin attenuates hypoxia-inducible factor-1alpha (HIF-1alpha) and its target genes in haemodiluted ratsDominador J Manalo
LBVB Laboratory of Biochemistry and Vascular Biology, Division of Hematology, CBER Center for Biologics Evaluation and Research, FDA Food and Drug Administration, NIH National Institutes of Health, Bethesda, MD 20892, USA
Biochem J 414:461-9. 2008Hb (haemoglobin)-based blood substitutes represent a class of therapeutics designed to correct oxygen deficit under conditions of anaemia and traumatic blood loss...
- Bovine polymerized hemoglobin versus Hextend resuscitation in a swine model of severe controlled hemorrhagic shock with delay to definitive careJennifer Rice
Naval Medical Research Center, Silver Spring, MD 20910, USA
Shock 26:302-10. 2006..01). In this swine model of controlled hemorrhage with low-volume resuscitation and delayed definitive care, HBOC-201 pigs had improved hemodynamics, transcutaneous tissue oxygen tension, and transfusion avoidance compared with HEX...
- Oxygen therapeutics: oxygen delivery without bloodJoanna L Stollings
Hospital Pharmacy Services, Mayo Clinic, Rochester, Minnesota 55902, USA
Pharmacotherapy 26:1453-64. 2006....
- Effects of isovolemic resuscitation with hemoglobin-based oxygen carrier Hemoglobin glutamer-200 (bovine) on systemic and mesenteric perfusion and oxygenation in a canine model of hemorrhagic shock: a comparison with 6% hetastarch solution and shed bloodB Driessen
Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, PA 19348, USA
Vet Anaesth Analg 33:368-80. 2006..To study Hemoglobin glutamer-200 bovine (Hb-200), 6% hetastarch (HES) and shed whole blood (WB) resuscitation in canine hemorrhagic shock...
- Haemoglobin, oxygen carriers and perioperative organ perfusionRoman Kocian
Institute of Anaesthesiology, University Hospital, Raemistrasse 100, 8091 Zurich, Switzerland
Best Pract Res Clin Anaesthesiol 22:63-80. 2008..Research into some of these compounds has been discontinued, while others have advanced into clinical phase III trials, but none has achieved market approval for Europe, US or Canada so far...
- Low-volume resuscitation cocktail extends survival after severe hemorrhagic shockPenny S Reynolds
Departments of Emergency Medicine, Virginia Commonwealth University Reanimation Engineering Shock Center, Virginia Commonwealth University Medical Center, Richmond, Virginia 23298 0401, USA
Shock 28:45-52. 2007..Experimental evaluation of any resuscitation therapy should account for the degree of preexisting physiological compromise before therapy is initiated...
- Cerebral oxygen delivery by liposome-encapsulated hemoglobin: a positron-emission tomographic evaluation in a rat model of hemorrhagic shockVibhudutta Awasthi
Department of Radiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
J Appl Physiol (1985) 103:28-38. 2007..suggest that 15O-PET technology can be successfully employed to evaluate potential oxygen carriers and blood substitutes and that LEH resuscitation in hemorrhage enhances oxygen delivery to the cerebral tissue and improves oxygen ..
- Alternatives to allogeneic blood transfusionsAndreas Pape
Clinic of Anoesthesiology, Intensive Care Medicine and Pain Management, J W Goethe University Hospital Frankfurt am Main, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
Best Pract Res Clin Anaesthesiol 21:221-39. 2007..Nevertheless, to date no artificial oxygen carrier is available for routine clinical use, and further studies are needed to show the safety and efficacy of these substances...
- Resuscitation with recombinant hemoglobin rHb2.0 in a rodent model of hemorrhagic shockJoerg Hermann
Institute for Surgical Research, Ludwig Maximilians University, Munich, Germany
Anesthesiology 107:273-80. 2007..This study compares resuscitation with a nonhemoglobin colloid and two recombinant hemoglobin solutions with wild-type and reduced nitric oxide-scavenging capacity...
- Effects of Diaspirin Crosslinked Hemoglobin (DCLHb) on microcirculation and local tissue pO2 of striated skin muscle following resuscitation from hemorrhagic shockSven Hungerer
Department for Surgery, Trauma Clinic Murnau, Murnau, Germany
Artif Cells Blood Substit Immobil Biotechnol 34:455-71. 2006..DCLHb effectively increases local tissue pO2 after resuscitation from hemorrhagic shock; however, not as effectively as 10 g% AUB...
- Coagulation patterns following haemoglobin-based oxygen carrier resuscitation in severe uncontrolled haemorrhagic shock in swineF Arnaud
Trauma and Resuscitative Medicine Department, Naval Medical Research Center, Silver Spring, Maryland 20910 7500, USA
Transfus Med 16:290-302. 2006..In this severe uncontrolled HS model, successful resuscitation with HBOC produced haemodilutional coagulopathy less than or similar to that produced by resuscitation with HEX...
- Oxygen transport during hemodilution with a perfluorocarbon-based oxygen carrier: effect of altitude and hyperoxiaTatiana Gardeazábal
Blood Substitutes Laboratory, Fundación Cardio Infantil, Carrera 1 Este No 19 40, Office ML817, University of Los Andes, PO Box 4976, Bogota, Colombia
J Appl Physiol (1985) 105:588-94. 2008..Therefore, the efficacy of PFCOCs at 2,600 m above sea level is reduced, and altitude must be taken into account when PFCOCs are used...
- Balance between vasoconstriction and enhanced oxygen deliveryPedro Cabrales
La Jolla Bioengineering Institute, Department of Bioengineering, University of California, San Diego, La Jolla, California 92037, USA
Transfusion 48:2087-95. 2008..Responses to facilitated O(2) transport, after exchange transfusion with PBH, were studied in the hamster window chamber model during acute extreme anemia to determine how PBH affects microvascular perfusion and tissue oxygenation...
- Enhanced central organ oxygenation after application of bovine cell-free hemoglobin HBOC-201Marc Freitag
Department of Anaesthesiology, University Hospital Hamburg Eppendorf, Martinistrasse 52, D 20246 Hamburg, Germany
Can J Anaesth 52:904-14. 2005....
- Prolonged low-volume resuscitation with HBOC-201 in a large-animal survival model of controlled hemorrhageColleen M Fitzpatrick
Department of Surgery, Wilford Hall Medical Center, Lackland Air Force Base, Texas, USA
J Trauma 59:273-81; discussion 281-3. 2005..This study compared a hemoglobin-based oxygen carrier (HBOC-201; Hemopure) to Hextend when used to treat hemorrhagic shock in situations of delayed definitive care military operations...
- Artificial O2 carriers: status in 2005Donat R Spahn
Department of Anesthesiology, University Hospital Lausanne, CH 1011 Lausanne, Switzerland
Curr Pharm Des 11:4099-114. 2005..The most advanced products are in clinical phase III trials but no product has achieved market approval yet in the US, Europe or Canada...
- Innate immune responses in Swine resuscitated from severe traumatic hemorrhagic shock with hemoglobin-based oxygen carrier-201C Hall
Naval Medical Research Center, Combat Casualty Care Directorate, Silver Spring, Maryland 20910, USA
Artif Cells Blood Substit Immobil Biotechnol 35:259-74. 2007..There was a trend to higher plasma IL-10 in HBOC-201 and groups vs. Hextend. We conclude that in swine with severe controlled HS and soft tissue injury, immune responses are similar with resuscitation with HBOC-201 and Hextend...
- Fluid resuscitation with hemoglobin vesicles in a rabbit model of acute hemorrhagic shockKatsuyuki Terajima
Department of Anesthesiology, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8603, Japan
Shock 25:184-9. 2006..HbV solution offers the advantages of systemic oxygenation without impairing microcirculation in the treatment of hemorrhagic shock...
- Hemoglobin-based oxygen carriers in trauma care: scientific rationale for the US multicenter prehosptial trialErnest E Moore
Department of Surgery, Denver Health Medical Center, and Department of Surgery, University of Colorado Health Sciences Center, Denver, CO 80204, USA
World J Surg 30:1247-57. 2006The greatest need for blood substitutes worldwide is in patients with unanticipated acute blood loss, and trauma is the most likely scenario...
- BIOENGINEERING DESIGN OF ARTIFICIAL BLOODMarcos Intaglietta; Fiscal Year: 2011..hemoglobin) overcomes the most significant hurdle to the development of modified hemoglobin-based blood substitutes, namely vasoconstriction...
- Biomimetic Approach to the Fabrication of Red Blood Cell MimicsJoseph M DeSimone; Fiscal Year: 2010..and manufacture a blood substitute and at this time there are no currently approved products for use as blood substitutes in North America or Europe...
- Mechanisms of Hemoglobin Adaptation to Hypoxia in High-altitude RodentsJay F Storz; Fiscal Year: 2012..may be possible to replicate the mechanism with novel drug-based therapy, gene therapy, and hemoglobin-based blood substitutes. This highly interdisciplinary study will integrate the tools and theory of molecular population genetics, ..
- Development of PEG Hemoglobin blood substitute to treat hemorrhagic shockAbe Abuchowski; Fiscal Year: 2009..to overcome many of these issues, efforts have been made to develop hemoglobin based oxygen carrier (HBOCs) blood substitutes which have advantages such as decreased chance of disease transmission, lack of a need for typing, and most ..
- Retrievable Blood Oxygen Carrier SystemAgnes E Ostafin; Fiscal Year: 2012Responding to ever increasing need for blood substitutes, scientists have developed two types of artificial oxygen carriers (AOC), polymeric hemoglobin and perfluorocarbon based AOC...
- Predicting Brain Recovery after Acute Hemorrhage and ResuscitationJohn J A Marota; Fiscal Year: 2010..hemorrhage, as well as elucidate the impact and optimal timing of resuscitation with blood or artificial blood substitutes. These data would strongly support the application of this technology to assess and manage patients ..
- Design of Heme Protein-Based Blood SubstitutesJohn S Olson; Fiscal Year: 2010..We have used the mechanisms governing these properties to design second-generation extracellular rHb-based blood substitutes with more efficient O2 transport and little or no hypertensive side effect in pre-clinical animal studies...
- Molecular and Biological Activities of Alpha Hemoglobin Stabilizing ProteinMitchell J Weiss; Fiscal Year: 2012..the role of AHSP in HbA synthesis may provide tools to optimize the manufacture of recombinant Hb-based blood substitutes. Finally, defining functional interactions between iron and AHSP could provide insights into the ..
- IRON AND OXYGEN CHEMISTRIES IN SIPUNCULAN BLOODDONALD KURTZ; Fiscal Year: 1992..applications which may arise from this work include new molecules for regulating redox chemistry of 02-carrying proteins and iron transport in human erythrocytes, and the use of hemerythrin as an oxygen carrier in blood substitutes.
- COMMUNICATION PATHWAYS IN CENTRAL CAVITY MODIFIED HBSJoel Friedman; Fiscal Year: 2000Many of the synthetic strategies to create hemoglobin based acellular blood substitutes, employ modifications that perturb the central cavity and extend the hydrodynamic volume...
- HEMOGLOBIN--A WORKBENCH TO STUDY PROTEIN ALLOSTERYArthur Arnone; Fiscal Year: 2004..This research would result in new insights into hemoglobin's molecular mechanism that may provide for better understanding and treatment of hemoglobinopathies and for the design of improved blood substitutes.
- CONTROL OF 02 TRANSPORT IN HEART AND SKELETAL MUSCLESTHOMAS GAYESKI; Fiscal Year: 1992..will provide insight into the clinical risks and benefits of administering or withholding blood or blood substitutes. Transport reserves must accommodate spatial and temporal heterogeneities of red cell flux...
- NOVEL CLASS OF FLUOROCARBONS AS BLOOD SUBSTITUTESGordhan Patel; Fiscal Year: 1990A novel class of fluorochemical are proposed as blood substitutes. The proposed compositions will be synthesized, purified, and characterized...
- PHYSICAL BASIS FOR DIAGNOSTIC 19F MR IMAGINGPeter Joseph; Fiscal Year: 1990..blood perfusion and oxygen tension in the brain using magnetic resonance imaging (MRI) of fluorinated blood substitutes (FBS), and to compare the results with those obtained using several techniques which have been proposed ..
- New Paradigms in the Design of Blood SubstitutesJoel Friedman; Fiscal Year: 2006..Manjula, AECOM) in amounts needed for Projects 2(NMR), 3(optical spectroscopy and ligand reactivity), 4(EPR) and 5(physiology). ..
- NOVEL ORGANIC REAGENTS FOR BIOMEDICAL APPLICATIONSRAMACHANDRA HOSMANE; Fiscal Year: 2002..organic reagents (PORs) for chemically modifying cell-free human hemoglobins for use as oxygen-carrying blood substitutes in emergency transfusions...
- CONSTRUCTION OF CAGE AND RACK WASHING FACILITYJOSEPH HARDER; Fiscal Year: 1992..and cancer chemoprevention, cancer chemotherapy, immunology and immunotoxicology, artificial blood substitutes, and AIDS therapeutics...
- MULTINUCLEAR MRI OF TUMORS IN ANIMALSPeter Joseph; Fiscal Year: 1991..The proton images will be used for their anatomical detail. The fluorine images will be of fluorinated blood substitutes and will dilineate vascular anatomy and measure the vascular oxygen tension...
- MOLECULAR CONTROLS OF HEMOGLOBIN FUNCTIONCelia Bonaventura; Fiscal Year: 2000Our working hypothesis is that successful Hb-based blood substitutes may be generate by cross linking and sulfhydryl modification, with fine-tuning achieved by site-directed mutagenesis that is guided by knowledge of the molecular ..
- Engineering H-NOX Domains for Therapeutic Oxygen DeliveryEMILY WEINERT; Fiscal Year: 2009..There is currently a need for blood substitutes because of shortages in the blood supply and potential infection spread through donated blood, especially in ..
- MOLECULAR FINGERPRINTING OF CROSS LINKED HEMOGLOBINSChien Ho; Fiscal Year: 2000..features of cross-linked hemoglobins (Hbs) that provide suitable properties as Hb-based oxygen carriers or blood substitutes. This information will help design "ideal" cross-linked Hbs with desired oxygen affinity, cooperativity, and ..
- HEMOGLOBIN UTILIZATION AND VIRULENCE OF MENINGOCOCCIIgor Stojiljkovic; Fiscal Year: 2002..meningitidis. Finally, understanding Hb-iron acquisition systems may assist scientists in design of a new family of Hb-based blood substitutes that do not increase the risk of infection by Hb-utilizing bacteria.
- RENOVATION OF BIOCHEMISTRY FACILITYScott Bass; Fiscal Year: 2002..Research in this space will focus on the development of antineoplastic and antiviral drugs, mechanisms of carcinogenesis and oxygen carrying blood substitutes for emergency transfusions.
- OXYGEN INDEPENDENT INTERFERENCE FREE GLUCOSE SENSORSJoseph Wang; Fiscal Year: 2000..The use of perfluorochemicals, often employed as blood substitutes due to their remarkable oxygen solubility, as a major component of the biocomposite electrode, should ..
- The function and regulation of alpha hemoglobin stabilizing protein (AHSP) in hemMitchell Weiss; Fiscal Year: 2007..Second, our studies may provide valuable details as to how AHSP can be exploited as a molecular chaperone to improve the manufacture of recombinant Hb-based artificial blood substitutes.
- LACTATE SENSORS FOR BIOENGINEERING & CARDIAC MONITORINGDale Baker; Fiscal Year: 2001..The fully characterized sensor will then be used in studies of myocardial ischemia and in the evaluation of blood substitutes.
- MULTINUCLEAR IN VIVO MRI/MRS--DEVELOPMENT & APPLICATIONRobert Mattrey; Fiscal Year: 1990..19F imaging of perfluorocarbon blood substitutes is important, since 19F relaxation rates are strongly influenced by 02 tension...
- CHELATING AGENTS AS BLOOD SUBSTITUTESJack Baldwin; Fiscal Year: 1980..The development of new oxygen carriers, based on chelates, is in progress. These are to be tested in vivo as oxygen transport equivalents. Modified forms of human hemoglobin are also being synthesized and tested for the same purposes. ..
- Oxygen Carriers for Hypovolemic Circulatory CollapseRobert Winslow; Fiscal Year: 2007..As such, the molecules we have produced are not "blood substitutes" per se, but a new class of therapeutic agent, effective in small volume, that "target" O2 to capillaries ..
- Bioengineering Methods to Study Blood SubstitutesAnthony Cheung; Fiscal Year: 2004..abstract_text> ..
- PORPHYRIN IONS AND RADICALS IN METABOLIC PROCESSESDavid Dolphin; Fiscal Year: 1991..Water soluble hemes, capable or reversibly binding dioxygen will be studied as possible blood substitutes.
- Instrument to Measure Oxygen Affinity of HemoglobinKim Vandegriff; Fiscal Year: 2004..abstract_text> ..
- PET Evaluation of Hemorrhagic Shock and ResuscitationVibhudutta Awasthi; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- NITRIC OXIDE 'NO' AND THE KIDNEYChris Baylis; Fiscal Year: 2003..Finally, she will evaluate the validity of the use of plasma and urinary NOX and will use Electron Spin Resonance (ESR) spectroscopy as an alternative method of determining NO production in vivo. ..
- COLLOIDAL IRON-OXIDE NANOBEACONS FOR THERANOSTIC USE IN ATHEROSCLEROSISGregory M Lanza; Fiscal Year: 2010..Demonstrate image-guided drug delivery of antiangiogenic therapy potential with ligand-targeted non-gadolinium nanoplatform in vivo. ..
- Mechanically Stable Blood SubstitutesAndre Francis Palmer; Fiscal Year: 2010..be engineered to create mechanically stable and shape changing vesicular dispersions for use as artificial blood substitutes. We postulate that control of liposome structure and mechanics can be engineered by varying liposome size ..
- EFFECTS OF AGE ON SIGNALING IN HUMAN OSTEOBLASTOGENESISJulie Glowacki; Fiscal Year: 2010....
- MOLECULAR ICE CONTROL FOR ENGINEERED TISSUESMichael Taylor; Fiscal Year: 2003..The potential markets are enormous. Cryopreservation methods, which result in retained viability and function, will be licensed to the tissue engineering industry. ..
- TRANSFUSION TRIGGER EXTENSION BY PLASMA EXPANDERSMarcos Intaglietta; Fiscal Year: 2009..Strategies for optimal follow up of plasma resuscitation and exchange with blood transfusion will be investigated. ..
- MECHANOSENSITIVE MODULATION OF AIRWAY CONTRACTIONChi Ming Hai; Fiscal Year: 2008..Understanding the basic science of this cellular mechanism may lead to new methods for the treatment of airway diseases such as asthma. ..
- FUNCTIONAL ASPECTS OF OXYGEN DELIVERYMarcos Intaglietta; Fiscal Year: 2004..Our research aims at advancing our understanding of tissue oxygenation and provides a new conceptual framework with which to analyze the ischemic process. ..
- RESEARCH TRAINING IN TRANSFUSION MEDICINEJeffrey McCullough; Fiscal Year: 2003..abstract_text> ..
- The Glycocalyx and Endothelial Barrier RegulationRANDAL DULL; Fiscal Year: 2005..This K08 will provide the foundation for a research career dedicated to understanding the molecular mechanisms of endothelial barrier regulation. ..
- TISSUE ENGINEERING OF GROWING JOINTSJulie Glowacki; Fiscal Year: 2002..In vivo fate of engineered joints will be assessed in our model of murine joint transplantation and will be further verified in the pig. ..
- Pancreas Transporter Development and ValidationMichael Taylor; Fiscal Year: 2006..This research program is supported by collaboration with three major clinical centers interested in validation of this perfusion technology for their future use. [unreadable] [unreadable]..
- Indiana and the Legacy of State and Local Eugenics 1907-2007William Schneider; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Ischemia Reperfusion Injury in the Diabetic HeartPaul McDonagh; Fiscal Year: 2007..The results will improve our understanding of the role of chronic and acute inflammation in I/R injury in the diabetic heart and suggest new, thoughtful approaches to treat this growing problem. [unreadable] [unreadable]..
- IMCD phosphodiesterase in pregnancy; role in ECFVEChris Baylis; Fiscal Year: 2008..unreadable] [unreadable]..
- Effect of Aging & Vitamin D Status on OsteoblastogenesisJulie Glowacki; Fiscal Year: 2008..abstract_text> ..
- Activation of clotting & cell adhesion: gas embolismDavid M Eckmann; Fiscal Year: 2010..This work is the basis for neuroprotection in gas embolism-induced stroke, a persistent, growing health threat without treatment. ..