Genomes and Genes
Summary: Drugs used for their effects on the gastrointestinal system, as to control gastric acidity, regulate gastrointestinal motility and water flow, and improve digestion.
Publications268 found, 100 shown here
- Maintenance infliximab for Crohn's disease: the ACCENT I randomised trialStephen B Hanauer
Department of Gastroenterology and Nutrition, University of Chicago Medical Center, Chicago, IL 60637, USA
Lancet 359:1541-9. 2002..We did a randomised controlled trial to assess the benefit of maintenance infliximab therapy in patients with active Crohn's disease who respond to a single infusion of infliximab...
- Efficacy and tolerability of a new formulation of pancrelipase delayed-release capsules in children aged 7 to 11 years with exocrine pancreatic insufficiency and cystic fibrosis: a multicenter, randomized, double-blind, placebo-controlled, two-period crosGavin R Graff
Penn State Milton S Hershey Medical Center, Penn State Medical School, Department of Pediatrics, Hershey, Pennsylvania 17033 0850, USA
Clin Ther 32:89-103. 2010..The US Food and Drug Administration regulations now require all PERT products to undergo clinical efficacy and safety studies before they can be considered for marketing approval...
- Rikkunshito improves the symptoms in patients with functional dyspepsia, accompanied by an increase in the level of plasma ghrelinMakoto Arai
Department of Medicine, Chiba University, Chiba, Japna
Hepatogastroenterology 59:62-6. 2012..The aim of this study was to investigate the effect of rikkunshito on upper gastrointestinal symptoms and the levels of acylated ghrelin (AG) in patients with FD...
- Review article: the treatment of functional abdominal bloating and distensionM Schmulson
Laboratory of Liver, Pancreas and Motility, Department of Experimental Medicine Faculty of Medicine, Universidad Nacional Autonoma de Mexico UNAM, Mexico
Aliment Pharmacol Ther 33:1071-86. 2011..Abdominal bloating and distension are common symptoms in patients with functional gastrointestinal disorders (FGIDs), however, relatively little is known about their treatment...
- Behçet's ileocolitis: successful treatment with tumor necrosis factor-alpha antibody (infliximab) therapy: report of a caseMichael T Kram
Department of Gastroenterology, Nyack Hospital, New York, USA
Dis Colon Rectum 46:118-21. 2003..To our knowledge this is the second reported case of Behçet's ileocolitis successfully treated with anti-tumor necrosis factor therapy...
- Anti-tumor necrosis factor monoclonal antibody therapy for gastrointestinal BehÃ§et's disease: a case reportP V Hassard
Inflammatory Bowel Disease Center, Division of Gastroenterology, Department of Medicine, Los Angeles, California, USA
Gastroenterology 120:995-9. 2001..This report suggests that infliximab may be an effective new therapy for gastrointestinal BD, and perhaps other manifestations of BD as well...
- A 6-month, open-label clinical trial of pancrelipase delayed-release capsules (Creon) in patients with exocrine pancreatic insufficiency due to chronic pancreatitis or pancreatic surgeryN Gubergrits
Department of Internal Diseases, Donetsk National Medical University, Donetsk, Ukraine
Aliment Pharmacol Ther 33:1152-61. 2011..Pancreatic enzyme replacement therapy (PERT) is necessary to prevent severe maldigestion and unwanted weight loss associated with exocrine pancreatic insufficiency (EPI) due to chronic pancreatitis (CP) or pancreatic surgery (PS)...
- Quality of life in patients with irritable bowel syndromeHubert Monnikes
Department of Medicine, Martin Luther Hospital, Academic Teaching Hospital of Charité Universitätsmedizin Berlin, Germany
J Clin Gastroenterol 45:S98-101. 2011..Evidence also indicates that HRQoL in patients with IBS is affected by sex and psychological conditions. Careful consideration of these factors may help to individualize a therapeutic strategy to optimize long-term outcomes...
- Somatostatin receptor subtypes mediate contractility on human colonic smooth muscle cellsV D Corleto
Department of Digestive and Liver Diseases, 1st and 2nd Schools of Medicine, University La Sapienza, Rome, Italy
Neurogastroenterol Motil 18:217-25. 2006..The contractile effects of SS are mediated through sstr subtype 2 and sstr subtype 1 on circular and longitudinal human colonic SMC, respectively...
- Efficacy and safety of Creon 24,000 in subjects with exocrine pancreatic insufficiency due to cystic fibrosisBruce C Trapnell
Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, and Division of Pulmonary, Sleep, and Critical Care Medicine, University of Cincinnati, 3333 Burnet Avenue, Cincinnati, OH, 45229 3039, USA
J Cyst Fibros 8:370-7. 2009..Pancreatic enzyme replacement therapy is critical for adequate nutrition in cystic fibrosis (CF) patients with exocrine pancreatic insufficiency (EPI)...
- Lactulose improves cognitive functions and health-related quality of life in patients with cirrhosis who have minimal hepatic encephalopathySrinivasa Prasad
Department of Hepatology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
Hepatology 45:549-59. 2007..42]); MANOVA for time and treatment, P=0.002. Improvement in HRQOL was related to the improvement in psychometry. CONCLUSION: Treatment with lactulose improves both cognitive function and HRQOL in patients with cirrhosis who have MHE...
- The association of serotonin transporter genetic polymorphisms and irritable bowel syndrome and its influence on tegaserod treatment in Chinese patientsYuyuan Li
Department of Gastroenterology and Hepatology, First Municipal People s Hospital of Guangzhou, Guangzhou Medical College, 1 Panfu Road, Guangzhou, 510180, P R China
Dig Dis Sci 52:2942-9. 2007....
- Assessment of meal induced gastric accommodation by a satiety drinking test in health and in severe functional dyspepsiaJ Tack
Department of Internal Medicine, Division of Gastroenterology, University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium
Gut 52:1271-7. 2003..Impaired gastric accommodation is a major pathophysiological mechanism in functional dyspepsia. The aim of the present work was to assess a satiety drinking test in the evaluation of accommodation in health and dyspepsia...
- A randomized controlled clinical trial of the serotonin type 3 receptor antagonist alosetron in women with diarrhea-predominant irritable bowel syndromeM Camilleri
Glaxo Wellcome Inc, 5 Moore Dr, Research Triangle Park, NC 27709, USA
Arch Intern Med 161:1733-40. 2001..CONCLUSION: Alosetron hydrochloride, 1 mg twice daily for 12 weeks, is effective in relieving pain and some bowel-related symptoms in diarrhea-predominant female patients with IBS...
- Pathophysiology and treatment of functional dyspepsiaJan Tack
Department of Internal Medicine, Division of Gastroenterology, University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium
J Clin Gastroenterol 39:S211-6. 2005..Thus, efforts to further elucidate underlying pathophysiologic mechanisms and identify the appropriate patient population using some type of pathophysiologic testing will be required...
- The in vitro pharmacological profile of prucalopride, a novel enterokinetic compoundM R Briejer
Department of Gastrointestinal Pharmacology, Janssen Research Foundation, Turnhoutseweg 30, 2340 Beerse, Belgium
Eur J Pharmacol 423:71-83. 2001....
- Non-absorbable disaccharides for hepatic encephalopathy: systematic review of randomised trialsBodil Als-Nielsen
Cochrane Hepato Biliary Group, Copenhagen Trial Unit, Centre for Clinical Intervention Research, Copenhagen University Hospital, Department 7102, H S Rigshospitalet, DK 2100 Copenhagen, Denmark
BMJ 328:1046. 2004..To assess the effects of non-absorbable disaccharides (lactulose and lactitol) in patients with hepatic encephalopathy...
- Prokinetics in acute upper GI bleeding: a meta-analysisAlan N Barkun
Division of Gastroenterology, McGill University Health Center, McGill University, Montreal, Quebec, Canada
Gastrointest Endosc 72:1138-45. 2010..Recent data suggest that administration of prokinetics before gastroscopy may be useful in patients with acute upper GI bleeding (UGIB). Published studies are limited in the number of subjects evaluated, and the conclusions are disparate...
- Multicenter, randomized, placebo-controlled trial of amitriptyline in children with functional gastrointestinal disordersMiguel Saps
Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Children s Memorial Hospital, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60614, USA
Gastroenterology 137:1261-9. 2009..The aim of this study was to evaluate the efficacy of amitriptyline in children with pain-predominant functional gastrointestinal disorders...
- Functional dyspepsia: mechanisms of symptom generation and appropriate management of patientsMichael Camilleri
Clinical Enteric Neuroscience Translational and Epidemiological Research Group, Mayo Clinic College of Medicine, Charlton 8 110, 200 First Street, SW, Rochester, MN 55905, USA
Gastroenterol Clin North Am 36:649-64, xi-x. 2007..To achieve greater therapeutic efficacy, it may be necessary to target the therapeutic approach to a specific pathophysiology, such as impaired gastric emptying...
- Acute pancreatitis, bacterial translocation, and different octreotide regimens: an experimental studyOsman Güler
Department of General Surgery, Ankara Training and Research Hospital, Ankara 06340, Turkey
Surg Today 39:876-83. 2009..To determine the effect of octreotide, octreotide with zinc, levamisole, and misoprostol on the bacterial translocation that develops in rats with acute pancreatitis (AP)...
- Systematic review: incidence of abdominal/pelvic surgery amongst patients using tegaserod in randomized controlled trialsP Schoenfeld
Division of Gastroenterology, University of Michigan School of Medicine and Veterans Affairs Center for Excellence in Health Services Research, Ann Arbor, MI 48105, USA
Aliment Pharmacol Ther 19:263-9. 2004....
- A randomized, double-blind, placebo-controlled study to assess efficacy and safety of 0.5 mg and 1 mg alosetron in women with severe diarrhea-predominant IBSRichard Krause
ClinSearch, Chattanooga, Tennessee, USA
Am J Gastroenterol 102:1709-19. 2007..Multiple dosing regimens were assessed in a randomized, double-blind, placebo-controlled study (S3B30040) to determine efficacy, tolerability, and evaluate constipation rate...
- Pancrelipase delayed-release capsules (CREON) for exocrine pancreatic insufficiency due to chronic pancreatitis or pancreatic surgery: A double-blind randomized trialDavid C Whitcomb
Department of Medicine, University of Pittsburgh, Pennsylvania, USA
Am J Gastroenterol 105:2276-86. 2010..Our objective was to assess the efficacy and safety of a new formulation of pancrelipase (pancreatin) delayed-release 12,000-lipase unit capsules (CREON) in patients with EPI due to CP or PS...
- Alosetron: ischemic colitis and serious complications of constipationHugo Gallo-Torres
Am J Gastroenterol 101:1080-3. 2006....
- The effect of mosapride on esophageal motility and bolus transit in asymptomatic volunteersYu Kyung Cho
Division of Gastroenterology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea
J Clin Gastroenterol 40:286-92. 2006..To evaluate the effect of mosapride, a selective 5-hydroxytryptamine-4 agonist, on esophageal motility and bolus transit in asymptomatic volunteers...
- A randomized placebo-controlled phase IIb trial of a3309, a bile acid transporter inhibitor, for chronic idiopathic constipationWilliam D Chey
Department of Medicine, University of Michigan Health System, Ann Arbor, 48109 5362, USA
Am J Gastroenterol 106:1803-12. 2011..We conducted an 8-week, multicenter, randomized, double-blind, placebo-controlled, parallel group, phase IIb study, which evaluated A3309 in patients with chronic idiopathic constipation (CIC)...
- Review article: cardiac adverse effects of gastrointestinal prokineticsM Tonini
Department of Internal Medicine and Therapeutics, Section of Experimental and Clinical Pharmacology, University of Pavia, Pavia, Italy
Aliment Pharmacol Ther 13:1585-91. 1999..g. ketoconazole, itraconazole, miconazole and fluconazole) and macrolide antibacterials (e.g. erythromycin, clarithrod-mycin and troleandomycin), which can inhibit cisapride metabolism by interfering with the CYP3A4 isoenzyme...
- Comparison of rifaximin and lactulose for the treatment of hepatic encephalopathy: a prospective randomized studyYong Han Paik
Department of Internal Medicine, Division of Gastroenterology, Yonsei University College of Medicine, Yongdong Severance Hospital, 146 92 Dogok dong, Gangnam Gu, Seoul 135 720, Korea
Yonsei Med J 46:399-407. 2005..There was no episode of renal function impairment in either treatment group. Rifaximin proved to be as safe and as effective as lactulose for the treatment of Korean patients with hepatic encephalopathy...
- Celiac disease: from pathogenesis to novel therapiesDetlef Schuppan
Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
Gastroenterology 137:1912-33. 2009..These and other experimental therapies will be discussed critically...
- The effects of oral pancreatic enzymes (Creon 10 capsule) on steatorrhea: a multicenter, placebo-controlled, parallel group trial in subjects with chronic pancreatitisMichael Safdi
Greater Cincinnati Gastroenterology Associates, Cincinnati, OH 45219, USA
Pancreas 33:156-62. 2006..Secondary objectives included evaluation of stool parameters and global improvement of symptoms scales...
- Safety assessment of prucalopride in elderly patients with constipation: a double-blind, placebo-controlled studyM Camilleri
Mayo Clinic, Rochester, MN 55905, USA
Neurogastroenterol Motil 21:1256-e117. 2009..Prucalopride up to 2 mg once daily for 4 weeks was safe and well-tolerated by constipated elderly patients, with no differences vs placebo in ECG or a range of Holter-monitoring parameters...
- Influence of mosapride citrate on gastric motility and autonomic nervous function: evaluation by spectral analyses of heart rate and blood pressure variabilities, and by electrogastrographyJunko Endo
Department of Gastroenterology, Kochi National Hospital, Kochi, Japan
J Gastroenterol 37:888-95. 2002..However, few studies have evaluated the influence of mosapride citrate on autonomic nervous activity and hemodynamics...
- The safety profile of anti-tumour necrosis factor therapy in inflammatory bowel disease in clinical practice: analysis of 620 patient-years follow-upC W Lees
Gastrointestinal Unit, Western General Hospital, Edinburgh, UK
Aliment Pharmacol Ther 29:286-97. 2009..Anti-TNF agents are now widely used in Crohn's disease (CD), and in ulcerative colitis (UC)...
- Incidence of ischemic colitis and serious complications of constipation among patients using alosetron: systematic review of clinical trials and post-marketing surveillance dataLin Chang
Center for Neurovisceral Sciences and Women s Health, Department of Medicine, UCLA and VA Greater Los Angeles Healthcare Center, California, USA
Am J Gastroenterol 101:1069-79. 2006..This systematic review calculated the incidence of these adverse events in alosetron-using patients in clinical trials and post-marketing surveillance...
- Helicobacter pylori eradication versus prokinetics in the treatment of functional dyspepsia: a randomized, double-blind studyTiing Leong Ang
Department of Gastroenterology, Changi General Hospital, 2 Simei Street 3, Singapore, 529889, Singapore
J Gastroenterol 41:647-53. 2006..This randomized, double-blind study compared the efficacy of Helicobacter pylori eradication against prokinetics in H. pylori-infected functional dyspepsia patients...
- Lack of association of tegaserod with adverse cardiovascular outcomes in a matched case-control studyJeffrey L Anderson
Cardiovascular Department, Intermountain Medical Center, Murray, Utah 84107, USA
J Cardiovasc Pharmacol Ther 14:170-5. 2009..This large epidemiologic study failed to confirm a reported large event differential for tegaserod that was noted incidentally in a clinical trials database, suggesting that the prior observation may have been due to chance...
- Effects of Baicalin and Octreotide on the serum TNF-alpha level and apoptosis in multiple organs of rats with severe acute pancreatitisHua Tian
Department of General Surgery, Affiliated Xiaoshan First People s Hospital, Hangzhou Normal University, Hangzhou, Zhejiang Province, China
Inflammation 32:191-201. 2009..05 or P < 0.01). Baicalin and Octreotide share a similar therapeutic efficacy in the treatment of SAP via a mechanism that is associated with inhibiting the levels of TNF-alpha in blood and induce apoptosis in multiple organs...
- Octreotide therapy for control of acute gastrointestinal bleeding in childrenY Eroglu
Department of Gastroenterology, Hepatology and Nutrition, Children s Memorial Hospital, Northwestern University Medical School, Chicago, IL 60614, USA
J Pediatr Gastroenterol Nutr 38:41-7. 2004..To evaluate the outcomes of octreotide use in children with gastrointestinal bleeding with or without portal hypertension...
- Effects of Velusetrag (TD-5108) on gastrointestinal transit and bowel function in health and pharmacokinetics in health and constipationM L Manini
Clinical Enteric Neuroscience Translational and Epidemiological Research, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
Neurogastroenterol Motil 22:42-9, e7-8. 2010..Velusetrag significantly accelerated intestinal and colonic transit after single dosing and accelerated gastric emptying after multiple dosing. Further studies of its potential as a gastrointestinal and colonic prokinetic are warranted...
- Infliximab maintenance therapy for fistulizing Crohn's diseaseBruce E Sands
Gastrointestinal Unit, Massachusetts General Hospital, and Harvard Medical School, Boston 02114, USA
N Engl J Med 350:876-85. 2004..It is not known whether infliximab is an effective maintenance therapy for patients with fistulas...
- Cisapride provides symptomatic relief in functional dyspepsia associated with gastric myoelectrical abnormalityJ D Chen
Division of Gastroenterology, University of Texas Medical Branch, Galveston, TX 77555 0764, USA
Aliment Pharmacol Ther 14:1041-7. 2000..We evaluated the effects of cisapride (10 mg t.d.s. and 20 mg b.d.) on gastrointestinal symptoms and gastric myoelectrical activity in patients with functional dyspepsia. Myoelectrical activity was measured by electrogastrography...
- Pediatric patients with dyspepsia have chronic symptoms, anxiety, and lower quality of life as adolescents and adultsSara W Rippel
Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee 37212, USA
Gastroenterology 142:754-61. 2012..Little is known about long-term health outcomes of children with dyspeptic symptoms. We studied the natural history of pediatric patients with dyspeptic symptoms, with and without histologic reflux, compared with healthy controls...
- Meta-analysis: erythromycin before endoscopy for acute upper gastrointestinal bleedingY Bai
Department of Gastroenterology, Changhai Hospital, Second Military Medical University, Shanghai, China
Aliment Pharmacol Ther 34:166-71. 2011..Studies evaluating the effect of erythromycin on patients with acute upper gastrointestinal bleeding (UGIB) had been reported, but the results were inconclusive...
- Erythromycin prior to endoscopy in acute upper gastrointestinal bleeding: a meta-analysisNicholas M Szary
Division of Gastroenterology, University of Missouri School of Medicine, Columbia, MO, USA
Scand J Gastroenterol 46:920-4. 2011..Therefore, a meta-analysis was performed comparing the efficacy of erythromycin infusion prior to endoscopy in acute UGIB...
- Randomised clinical trial: the efficacy and safety of pancreatin enteric-coated minimicrospheres (Creon 40000 MMS) in patients with pancreatic exocrine insufficiency due to chronic pancreatitis--a double-blind, placebo-controlled studyV Thorat
Department of Medical Gastroenterology, Poona Hospital and Research Centre, Pune, India
Aliment Pharmacol Ther 36:426-36. 2012..Pancreatic exocrine insufficiency (PEI) results in maldigestion, leading to abdominal pain, steatorrhoea, malnutrition and weight loss...
- Erythromycin vs metoclopramide for facilitating gastric emptying and tolerance to intragastric nutrition in critically ill patientsRobert MacLaren
Department of Clinical Pharmacy, School of Pharmacy, University of Colorado at Denver and Health Sciences Center, Aurora, CO 80045, USA
JPEN J Parenter Enteral Nutr 32:412-9. 2008..The purpose of this study is to evaluate erythromycin vs metoclopramide for facilitating gastric emptying and tolerance to intragastric enteral nutrition (EN)...
- Hepatic EncephalopathyA T Blei
Department of Medicine, Lakeside VA Medical Center and Northwestern University, Chicago, Illinois 60611, USA
Am J Gastroenterol 96:1968-76. 2001..In patients with significant deficits or complaints, a therapeutic program based on dietary manipulations and/or nonabsorbable disaccharides may be tried. Benzodiazepines should not be used for patients with sleep difficulties...
- Lubiprostone for the treatment of adults with constipation and irritable bowel syndromeRon Schey
Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, 4576 JCP, Iowa City, IA 52242, USA
Dig Dis Sci 56:1619-25. 2011..Thus far, lubiprostone offers a novel approach to our therapeutic armamentarium, however, there is a need for more drugs with different mechanisms of action, in order to treat constipation that is often multifunctional...
- General practitioner prescribing patterns in Babol city, Islamic Republic of IranA A Moghadamnia
Department of Pharmacology, Babol, Islamic Republic of Iran
East Mediterr Health J 8:550-5. 2002..Injections were prescribed in 58.0% of encounters. Female and male doctors had significantly different antibiotic prescribing patterns. Our study confirms the tendency of GPs to overprescribe...
- Erythromycin dose of 70 mg accelerates gastric emptying as effectively as 200 mg in the critically illMarc A Ritz
Department of Gastrointestinal Medicine, Royal Adelaide Hospital, 5000, Adelaide, SA, Australia
Intensive Care Med 31:949-54. 2005..To compare the effectiveness of 70-mg and 200-mg doses of intravenous erythromycin in improving gastric emptying in critically ill patients...
- Protective effects of baicalin and octreotide on intestinal mucosa of rats with severe acute pancreatitisXiping Zhang
Department of General Surgery, Hangzhou First People s Hospital, Zhejiang Province, China
Turk J Gastroenterol 20:108-15. 2009..To compare the protective effects of baicalin and octreotide on intestinal mucosa of rats with severe acute pancreatitis and to explore the application value of baicalin as a new drug...
- Erythromycin infusion or gastric lavage for upper gastrointestinal bleeding: a multicenter randomized controlled trialDominique Pateron
Emergency Department, Saint Antoine Hospital, Assistance Publique Hopitaux de Paris, Pierre et Marie Curie Paris 6 University, Paris, France
Ann Emerg Med 57:582-9. 2011..We determine whether in acute upper gastrointestinal bleeding the frequency of satisfactory stomach visualization was different after intravenous erythromycin, a nasogastric tube with gastric lavage, or both...
- Meta-analysis: somatostatin or its long-acting analogue, octreotide, for prophylaxis against post-ERCP pancreatitisFumio Omata
St Luke s International Hospital, 9 1 Akashichyo, Chuoku, Tokyo 104 8560, Japan
J Gastroenterol 45:885-95. 2010..Previous meta-analyses and randomized controlled trials have shown conflicting results regarding the preventive efficacy of somatostatin or octreotide for this complication. The aim of this study was to resolve these conflicts...
- Linaclotide is a potent and selective guanylate cyclase C agonist that elicits pharmacological effects locally in the gastrointestinal tractAlexander P Bryant
Ironwood Pharmaceuticals, Inc, 320 Bent Street, Cambridge, MA 02141, USA
Life Sci 86:760-5. 2010....
- 5-HT4 receptor agonists: similar but not the sameJ H De Maeyer
Movetis NV, Turnhout, Belgium
Neurogastroenterol Motil 20:99-112. 2008..Selective 5-HT(4) receptor agonists might thus prove to be innovative drugs with an attractive safety profile for better treatment of patients suffering from hypomotility disorders...
- Erythromycin infusion prior to endoscopy for acute upper gastrointestinal bleeding: a randomized, controlled, double-blind trialNicholas Carbonell
Service d Hepatologie, Hopital Saint Antoine, Paris, France
Am J Gastroenterol 101:1211-5. 2006..We investigated whether the association of erythromycin infusion to gastric lavage could improve stomach cleansing before endoscopy...
- Presynaptic modulation of cholinergic neurotransmission in the human proximal stomachPascal G Leclere
Heymans Institute of Pharmacology, Ghent University, Faculty of Medicine and Health Sciences, De Pintelaan 185, B 9000 Ghent, Belgium
Br J Pharmacol 135:135-42. 2002..No evidence for modulation by NO or VIP was obtained...
- The 5-HT2B antagonist and 5-HT4 agonist activities of tegaserod in the anaesthetized ratJ L McCullough
Department of Pharmacology, Theravance Inc, 901 Gateway Boulevard, South San Francisco, CA 94080, USA
Pharmacol Res 53:353-8. 2006..The clinical relevance of the 5-HT2B receptor antagonism of tegaserod remains to be determined...
- Diminished efficacy of colonic adaptation to lactulose occurs in patients with inflammatory bowel disease in remissionAndrew Szilagyi
Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada
Dig Dis Sci 47:2811-22. 2002..In conclusion, although controls adapt to a 3-week period of lactulose ingestion, IBD patients fail to meet the criteria for adaptation. However, longer studies may be needed to establish whether IBD patients are slower to adapt...
- Effect of clebopride, antidopaminergic gastrointestinal prokinetics, on cardiac repolarizationKi Suk Kim
Department of Pharmacology and National Research Laboratory, Korea Institute of Toxicology, Korea Research Institute of Chemical Technology, Yuseong, Daejeon, Korea
Int J Toxicol 26:25-31. 2007..But, in a supratherapeutic concentration that might possibly be encountered during overdose or impaired metabolism, clebopride may have torsadogenic potency...
- Safety, tolerability and satisfaction with tegaserod therapy in Asia-Pacific patients with irritable bowel syndrome with constipationKwong M Fock
Changi General Hospital, Singapore, Singapore
J Gastroenterol Hepatol 22:1190-8. 2007....
- Safety, tolerability, and efficacy of tegaserod over 13 months in patients with chronic constipationStefan Müller-Lissner
Park Klinik Weissensee, Berlin, Germany
Am J Gastroenterol 101:2558-69; quiz 2671. 2006..To assess the long-term safety and tolerability of tegaserod in patients with chronic constipation (CC)...
- Prucalopride: a new drug for the treatment of chronic constipationJan Tack
Department of Internal Medicine, Division of Gastroenterology, University Hospital Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
Expert Rev Gastroenterol Hepatol 3:337-43. 2009..The Phase III studies mainly recruited patients with insufficient response to laxatives, and showed consistent efficacy and excellent tolerability for prucalopride...
- The effect of octreotide as an adjunct treatment in active nonvariceal upper gastrointestinal bleedingVassiliki N Nikolopoulou
Department of Internal Medicine, Division of Gastroenterology, University Hospital, Patras, Greece
J Clin Gastroenterol 38:243-7. 2004..The aim of this study was to determine the effect ofoctreotide on active or recent gastrointestinal bleeding from benign peptic ulcers...
- The effect of cisapride on oesophageal motility and lower sphincter function in patients with gastro-oesophageal reflux diseaseCaterina Finizia
Departments of Otorhinolaryngology and Surgery, Sahlgrenska University Hospital, 413 45 Goteborg, Sweden
Eur J Gastroenterol Hepatol 14:9-14. 2002..To evaluate the efficiency by which the 5-HT4 agonist cisapride affects important motor functions involved in the control of gastro-oesophageal reflux...
- Infliximab or cyclosporine as rescue therapy in hospitalized patients with steroid-refractory ulcerative colitis: a retrospective observational studyMats Sjöberg
Department of Medicine, Skaraborgs Hospital, Lidköping, Sweden
Inflamm Bowel Dis 18:212-8. 2012..Cyclosporine (CsA) or infliximab (IFX) are used as rescue therapies in steroid-refractory, severe attacks of ulcerative colitis (UC). There are no data comparing the efficacy of these two alternatives...
- Torsades de pointes ventricular tachycardia induced by mosapride and flecainide in the presence of hypokalemiaR Ohki
Department of Cardiology, Jichi Medical School, Minamikawachi, Tochigi 329 0498, Japan
Pacing Clin Electrophysiol 24:119-21. 2001..48 to 0.56 seconds and self-terminating torsades de pointes occurred. We considered that this proarrhythmia was induced by mosapride in combination with antiarrhythmic agents...
- Does cisapride influence cardiac rhythm? Results of a United States multicenter, double-blind, placebo-controlled pediatric studyJ Levy
Babies and Children s Hospital of New York, Columbia University College of Physicians and Surgeons, New York 10032 3784, USA
J Pediatr Gastroenterol Nutr 32:458-63. 2001..This study sought to analyze electrocardiograms (ECGs) from a multicenter pediatric study and to identify abnormalities in QTc interval associated with cisapride use...
- Critical flicker frequency for diagnosis and assessment of recovery from minimal hepatic encephalopathy in patients with cirrhosisPraveen Sharma
Department of Gastroenterology, G B Pant Hospital, New Delhi, India
Hepatobiliary Pancreat Dis Int 9:27-32. 2010..Diagnosis of MHE requires cumbersome tests. Lactulose is effective in the treatment of MHE. This study aimed to evaluate the use of critical flicker frequency (CFF) for the diagnosis of MHE in cirrhotic patients after treatment...
- Coprescribing and codispensing of cisapride and contraindicated drugsJ K Jones
Director of Research, The Degge Group, Ltd, 1616 N Fort Myer Dr, No. 1430, Arlington, VA 22209, USA
JAMA 286:1607-9. 2001..The pharmacy may be an important and underutilized intervention point to prevent contraindicated drugs from being used together...
- Use of octreotide to treat prolonged sulfonylurea-induced hypoglycemia in a patient with chronic renal failureC M Nzerue
Department of Medicine, Renal Section, University of Rochester School of Medicine, Rochester, NY 14642, USA
Int J Artif Organs 26:86-9. 2003..Our experience suggests that use of octerotide to treat refractory or prolonged sulfonylurea-included hypoglycemia in renal failure patients is safe and effective; large prospective studies would be needed to validate these findings...
- Long-term efficacy and cost-effectiveness of polyethylene glycol 3350 plus electrolytes in chronic constipation: a retrospective study in a disabled populationI Migeon-Duballet
CHU de Poitiers, Hopital La Miletrie, Poitiers, France
Curr Med Res Opin 22:1227-35. 2006..The study also attempted an economic evaluation of the use of PEG+E in this setting...
- Effects of chenodeoxycholate and a bile acid sequestrant, colesevelam, on intestinal transit and bowel functionSuwebatu T Odunsi-Shiyanbade
Clinical Enteric Neuroscience Translational and Epidemiological Research, Mayo Clinic, Rochester, Minnesota 55905, USA
Clin Gastroenterol Hepatol 8:159-65. 2010..Di-alpha hydroxy bile salt, sodium chenodeoxycholate (CDC), and bile acid binding have unclear effects on colonic transit in health and disease...
- The proximal colonic motor response to rectal mechanical and chemical stimulationP A Bampton
Department of Gastroenterology, The St George Hospital, University of New South Wales, Sydney, Australia 2217
Am J Physiol Gastrointest Liver Physiol 282:G443-9. 2002..Rectal distension inhibits all colonic motor activity...
- Pilot study on the effect of linaclotide in patients with chronic constipationJeffrey M Johnston
Ironwood Pharmaceuticals, Inc, 320 Bent Street, Cambridge, MA, USA
Am J Gastroenterol 104:125-32. 2009..In Phase 1 studies in healthy human volunteers, linaclotide was well-tolerated, increased bowel movement frequency, and loosened stool consistency...
- Effect of tegaserod on gut transit in male and female subjectsL Degen
Department of Research and Clinical Research Center, University Hospital, Basel, Switzerland
Neurogastroenterol Motil 17:821-6. 2005..The results imply that tegaserod is a potent prokinetic agent throughout the GI in both sexes...
- Gastrointestinal prokinetic drugs have different affinity for the human cardiac human ether-Ã -gogo K(+) channelF Potet
, , Nantes, France
J Pharmacol Exp Ther 299:1007-12. 2001..We also conclude that 5-HT4 agonists devoid of side effects on the HERG current such as mosapride can be found as a safe alternative to cisapride...
- Effect of tegaserod in chronic constipation: a randomized, double-blind, controlled trialJohn F Johanson
University of Illinois College of Medicine, Rockford, IL, USA
Clin Gastroenterol Hepatol 2:796-805. 2004..Chronic constipation is a common gastrointestinal disorder. The aim of this study was to evaluate the efficacy, safety, and tolerability of tegaserod, a serotonin subtype 4 receptor partial agonist in patients with chronic constipation...
- Orally administered betaine has an acute and dose-dependent effect on serum betaine and plasma homocysteine concentrations in healthy humansUrsula Schwab
Department of Clinical Nutrition, University of Kuopio, Finland
J Nutr 136:34-8. 2006..In conclusion, a single dose of orally administered betaine had an acute and dose-dependent effect on serum betaine concentration and resulted in lowered plasma tHcy concentrations within 2 h in healthy subjects...
- Hepatosplenic T-cell lymphoma in an adolescent patient after immunomodulator and biologic therapy for Crohn diseaseMeena Thayu
Division of Gastroenterology and Nutrition, The Children s Hospital of Philadelphia, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA
J Pediatr Gastroenterol Nutr 40:220-2. 2005
- Protective effects of baicalin and octreotide on multiple organ injury in severe acute pancreatitisXi Ping Zhang
Department of General Surgery, Hangzhou First People s Hospital, 261 Huansha Road, Hangzhou, Zhejiang Province 310006, China
Dig Dis Sci 53:581-91. 2008..To discuss the application value of Baicalin which is a new drug by comparing the protecting effects of Baicalin and Octreotide on multiple organs (pancreas, liver, kidney, and lung) in Severe acute pancreatitis (SAP)...
- Effect of mosapride on gastrointestinal transit time and diagnostic yield of capsule endoscopyWei Wei
Department of Gastroenterology, Renji Hospital, Shanghai Institute of Digestive Diseases, Shanghai Jiao Tong University School of Medicine, Shanghai, China
J Gastroenterol Hepatol 22:1605-8. 2007..The aim of this study was to determine the effect of oral mosapride on gastrointestinal transit time and the diagnostic yield of CE...
- Double-blind randomized evaluation of clinical and biological tolerance of polyethylene glycol 4000 versus lactulose in constipated childrenChristophe Dupont
Hopital Saint Vincent de Paul, Service de Neonatologie, Paris, France
J Pediatr Gastroenterol Nutr 41:625-33. 2005..To assess the safety of a polyethylene glycol (PEG) 4000 laxative without additional salts in pediatric patients...
- Teduglutide (ALX-0600), a dipeptidyl peptidase IV resistant glucagon-like peptide 2 analogue, improves intestinal function in short bowel syndrome patientsP B Jeppesen
Department of Medicine CA 2121, Section of Gastroenterology, Rigshospitalet, University Hospital of Copenhagen, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
Gut 54:1224-31. 2005..The safety and effect of teduglutide were investigated in SBS patients with and without a colon in continuity...
- A randomized, multicenter comparison of polyethylene glycol laxative and tegaserod in treatment of patients with chronic constipationJack A Di Palma
Division of Gastroenterology, University of South Alabama College of Medicine, Mobile, Alabama 36693, USA
Am J Gastroenterol 102:1964-71. 2007..This study was designed to compare the efficacy of each product over a 4-wk treatment period...
- Effect of alosetron on bowel urgency and global symptoms in women with severe, diarrhea-predominant irritable bowel syndrome: analysis of two controlled trialsAnthony J Lembo
Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
Clin Gastroenterol Hepatol 2:675-82. 2004..The aim of this study was to assess the effect of alosetron on bowel urgency and irritable bowel syndrome (IBS) global improvement in diarrhea-predominant IBS (D-IBS)...
- Cisapride versus placebo for 8 weeks on glycemic control and gastric emptying in insulin-dependent diabetes: a double blind cross-over trialG Stacher
Department of Surgery, University of Vienna, Austria
J Clin Endocrinol Metab 84:2357-62. 1999..Blood glucose levels before and during assessment of emptying did not affect emptying, but the glucose rise over fasting levels was greater with faster emptying...
- Pharmacological effects of oxytocin on gastric emptying and intestinal transit of a non-nutritive liquid meal in female ratsChiu Lung Wu
Department of Physiology, School of Medicine, National Yang Ming University, Shih Pai, Taipei 11221, Taiwan, Republic of China
Naunyn Schmiedebergs Arch Pharmacol 367:406-13. 2003..These results suggest that OT inhibits gastric emptying and gastrointestinal transit in female rats via a mechanism involving CCK stimulation and CCK(1) receptor activation...
- Efficacy and tolerability of Creon for Children in infants and toddlers with pancreatic exocrine insufficiency caused by cystic fibrosis: an open-label, single-arm, multicenter studyCarla Colombo
CF Center of Milano, Fondazione IRCCS Ospedale Policlinico, Mangiagalli, Regina Elena, Milano, and University of Milan, Milan, Italy
Pancreas 38:693-9. 2009..To evaluate the efficacy and safety of a pancreatic enzyme preparation specifically developed for infants and small children with cystic fibrosis (CF)...
- Patient satisfaction with alosetron for the treatment of women with diarrhea-predominant irritable bowel syndromeKevin Olden
Mayo Clinic Scottsdale, Scottsdale, Arizona, USA
Am J Gastroenterol 97:3139-46. 2002....
- Role of duodenal lipid and cholecystokinin A receptors in the pathophysiology of functional dyspepsiaC Feinle
Gastroenterology Division, University Hospital Zurich, Switzerland
Gut 48:347-55. 2001....
- Long-term safety of tegaserod in patients with constipation-predominant irritable bowel syndromeG Tougas
Medicine and Gastroenterology, McMaster University Medical Center, Hamilton, Canada
Aliment Pharmacol Ther 16:1701-8. 2002..Tegaserod is a 5-hydroxytryptamine-4 receptor partial agonist. Oral administration causes gastrointestinal effects resulting in increased gastrointestinal motility and attenuation of visceral sensation...
- Chenodeoxycholate in females with irritable bowel syndrome-constipation: a pharmacodynamic and pharmacogenetic analysisArchana S Rao
Clinical Enteric Neuroscience Translational and Epidemiological Research, Division of Biomedical Statistics and Informatics, College of Medicine, Mayo Clinic, Rochester, Minnesota, USA
Gastroenterology 139:1549-58, 1558.e1. 2010..Sodium chenodeoxycholate (CDC) accelerates colonic transit in health. Our aim was to examine pharmacodynamics (colonic transit, bowel function) and pharmacogenetics of CDC in constipation-predominant irritable bowel syndrome (IBS-C)...
- Lubiprostone: a novel treatment for chronic constipationBrian E Lacy
Section of Gastroenterology and Hepatology, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
Clin Interv Aging 3:357-64. 2008..This article will provide a brief overview on chloride channel function in the gastrointestinal tract, describe the structure, function, and pharmacokinetics of lubiprostone, and discuss the safety and efficacy of this new medication...
- Octreotide therapy: a new horizon in treatment of iatrogenic chyloperitoneumC Bhatia
Royal Brompton and Harefield NHS Trust, Paediatric Surgical Unit, Harefield Hospital, Harefield, Middlesex UB9 6JH, UK
Arch Dis Child 85:234-5. 2001..We believe this to be the first report of successful use of octreotide in iatrogenic chyloperitoneum in a child...
- Clinical trial: lubiprostone in patients with constipation-associated irritable bowel syndrome--results of two randomized, placebo-controlled studiesD A Drossman
University of North Carolina Center for Functional Gl and Mobility Disorders, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Aliment Pharmacol Ther 29:329-41. 2009..Effective treatments for irritable bowel syndrome with constipation (IBS-C) are lacking...
- Infliximab for patients with refractory ulcerative colitisW Y Chey
Rochester Institute for Digestive Disease and Sciences, New York 14607, USA
Inflamm Bowel Dis 7:S30-3. 2001..001). In conclusion, infliximab improved clinical, endoscopic, and histologic outcomes in patients with severely active UC refractory to conventional therapy, allowing corticosteroid sparing and reducing the need for colectomy...
- Effects of a motilin receptor agonist (ABT-229) on upper gastrointestinal symptoms in type 1 diabetes mellitus: a randomised, double blind, placebo controlled trialN J Talley
Department of Medicine, University of Sydney, Nepean Hospital, Penrith NSW, Australia
Gut 49:395-401. 2001..CONCLUSIONS: The motilin agonist ABT-229 was not efficacious in the relief of postprandial symptoms in diabetes mellitus in the presence or absence of delayed gastric emptying...
- Evaluation of the efficacy and safety of rifaximin in the treatment of hepatic encephalopathy: a double-blind, randomized, dose-finding multi-centre studyR Williams
Liver Research Unit, King s College Hospital, London, UK
Eur J Gastroenterol Hepatol 12:203-8. 2000..To determine the efficacy, tolerability and safety of oral rifaximin given at three dose levels in patients with cirrhosis and mild to moderate hepatic encephalopathy (HE)...
- Lubiprostone, a locally acting chloride channel activator, in adult patients with chronic constipation: a double-blind, placebo-controlled, dose-ranging study to evaluate efficacy and safetyJ F Johanson
Rockford Gastroenterology Associates, Rockford, IL, USA
Aliment Pharmacol Ther 25:1351-61. 2007..Lubiprostone, a locally acting type-2 chloride channel activator, induces intestinal fluid secretion...
- ESTABLISHMENT AND EXPANSION OF A SPF RHESUS COLONY: AIDS, GENOMERudolf P Bohm; Fiscal Year: 2011..of morbidity and mortality in the TNPRC SPF breeding colonies, we plan to screen animals for selected gastrointestinal agents to further clarify their roles in disease and develop prevention and possible treatment strategies...
- AMIA 2002 Spring Congress: A Drug By Any Other NameDaniel Sands; Fiscal Year: 2002..abstract_text> ..
- NOVEL MAGAININ DRUGS FOR PSEUDOMEMBRANOUS COLITISW Maloy; Fiscal Year: 1992..This project may yield important gastrointestinal drugs with improved potency against C. difficile and excellent market potential. It will also advance the fields of peptide antibiotics and host defense therapy...
- Cannabinoid Mechanisms in Human Gastrointestinal Motor and Sensory FunctionsMICHAEL L CAMILLERI; Fiscal Year: 2010..These actions may be relevant to develop new treatments for IBS. The studies will also provide further understanding of the potential of medications like medical marijuana on stomach function that may be relevant to appetite control. ..
- ALPHA-2 ADRENERGIC CONTROL OF COLONIC FUNCTION IN IBSMichael Camilleri; Fiscal Year: 2007..abstract_text> ..
- ALPHA 2 ADRENERGIC CONTROL IN IRRITABLE BOWEL SYNDROMEMichael Camilleri; Fiscal Year: 2008..Significance: This project will characterize pharmacogenetic mechanisms determining the response to clonidine through studies of candidate genes that control alpha2-adrenoreceptor function and norepinephrine transport in IBS. ..
- OSCCAR: A Novel, Population-based Prospective Inception Cohort of Inflammatory BoBRUCE SANDS; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- IMURAN Dose Ranging Study in Crohn's DiseaseBRUCE SANDS; Fiscal Year: 2005..Abstract Not Provided ..
- IMMUNOMODULATION IN INFLAMMATORY BOWEL DISEASEBRUCE SANDS; Fiscal Year: 2004..The principal investigator seeks to become an independent clinical investigator by completing the didactic and scientific portions of this proposal. ..
- Mechanisms and Therapeutics in Cancer Anorexia/CachexiaAminah Jatoi; Fiscal Year: 2004..This K23 grant application will serve as a springboard to allow her to delve into the pathophysiology of this syndrome and to develop into an independent clinical investigator. ..
- Creatine: Is It a Body Builder for Cancer Patients?Aminah Jatoi; Fiscal Year: 2004..obtain longitudinal toxicity and quality of life data on this same cohort of 50 patients and will make direct comparisons between treatment arms on toxicity incidence and severity and on maximal quality of life scores ..
- Colonic Bacterial Synthesis of Butyric AcidCRAIG KIEN; Fiscal Year: 2004....
- DIFFERENTIAL METABOLISM OF DIETARY FATTY ACIDSCRAIG KIEN; Fiscal Year: 2003..In specific aim 4, the PI will measure the thermic effect of feeding during both the solid food and formula diet periods. The PI hypothesizes that the high OA feeding will be associated with a higher thermic effect of feeding. ..
- Mechanisms for differential effects of dietary fatty acids on metabolismCRAIG LAWRENCE KIEN; Fiscal Year: 2010..important new information regarding how mitochondrial malfunction, modified by dietary FA, plays a central role in the development of obesity, the metabolic syndrome, type 2 diabetes, and both heritable and age-related metabolic diseases ..
- Neuropeptide Y for Cancer-Associated AnorexiaAminah Jatoi; Fiscal Year: 2003..These two pilot studies will allow us to lay the groundwork for such larger trials. Our ultimate goal is to help cancer patients who suffer from anorexia. ..
- Pulmonary Alveolar Proteinosis Research ConferenceBruce Trapnell; Fiscal Year: 2005..This conference will provide a forum where thought leaders focused on the molecular and cellular basis or clinical management of PAP will present cutting edge research, integrate concepts, and chart innovative research directions. ..
- Regulation of Alveolar Macrophage PhagocytosisBruce Trapnell; Fiscal Year: 2006..1, and Hck/SFKs in AMs. Results of this research are expected to help establish the feasibility of the therapeutic use of GM-CSF in the treatment of lung infections by a wide variety of microbial pathogens. ..
- NF-kB in the intestinal radiation responseLaurence Egan; Fiscal Year: 2005..These results will provide mechanistic insight into an important medically relevant problem, amd will point the way towards novel therapies to prevent radiation injury to the intestines. ..
- Fourth Annual International Pulmonary Alveolar Proteinosis Research ConferenceBruce Trapnell; Fiscal Year: 2006..unreadable] [unreadable] [unreadable] [unreadable]..
- IKK Beta In Intestinal InflammationLaurence Egan; Fiscal Year: 2005..abstract_text> ..
- Conference--Pulmonary Alveolar Proteinosis ResearchBruce Trapnell; Fiscal Year: 2004..Recent progress in PAP research represents a paradigm of the intersection of basic science, clinical medicine and translational research, which has taken this disease from obscurity to clarity in a decade. ..
- AAT Deficiency & Liver Diseases Caused by ProteinsBruce Trapnell; Fiscal Year: 2006..unreadable] [unreadable]..
- GM-CSF & Alveolar Macrophage Antiviral Lung DefenseBruce Trapnell; Fiscal Year: 2004..abstract_text> ..
- BIOLOGY OF HUMAN INTRAEPITHELIAL LYMPHOCYTESEllen Ebert; Fiscal Year: 2002..These studies will determine the mechanism of IEL chemotaxis toward secreted products of ECs, why IL-15 is more potent than IL-2 in inducing LAK activity by IELs, and how IL-10 and IL-12 augment this activity. ..
- PGP Regulation of Antipsychotic Exposure and EffectsC Devane; Fiscal Year: 2008..The results of this research will provide support for translational studies in humans to refine treatment guidelines for the use of this class of medications in severely mentally ill patients. ..
- GROWTH AND DEATH SIGNALS IN THE PROSTATEMaria Abreu; Fiscal Year: 2002..After this three year period of training, I will return to gastrointestinal research with the support of my co-sponsor and begin to develop intestinal models to study normal and pathologic states of apoptosis. ..
- Impact of Medicaid Prescription Copayments in Patients with SchizophreniaJalpa Doshi; Fiscal Year: 2009..The findings of our study will help inform policymakers about the intended and unintended consequences of prescription copayments in Medicaid patients with schizophrenia. ..
- Music Therapy for Cancer Patients at the End of LifeKristine Nelson; Fiscal Year: 2004....
- Dietary Treatment of Crohn's DiseaseEce Mutlu; Fiscal Year: 2007..Significance. This study could provide information to suggest diet as a safe therapy for IBD and lay the groundwork for more definitive, randomized, controlled trials. ..
- INDUCTION OF APOPTOSIS BY HIV-1 INFECTED MONOCYTIC CELLSLloyd Mayer; Fiscal Year: 2007..abstract_text> ..
- MEDIATORS AND MODULATION OF NOCICEPTIONGerald Gebhart; Fiscal Year: 2008..Better appreciation of these differences will enhance our understanding of the contributions these cells make to nociceptive processing, including their role in mechanisms of hyperalgesia. ..
- Prenatal Exposure to Polyfluoroalkyl Compounds in the EMA StudyLisa A Croen; Fiscal Year: 2010..In the long-term, a better understanding of the underlying biology may suggest appropriate strategies for early intervention and contribute to the eventual prevention of this often devastating and usually life-long disability. ..
- NATURAL AND INDUCED IMMUNITY AGAINST HELICOBACTER PYLORIPierre Michetti; Fiscal Year: 2001..felis infection and during mucosal immunization in both mice and humans. These studies may also contribute to the development of effective vaccination strategies against other enteric pathogens. ..
- VIP-induced gene expression in colonic smooth muscle cellsSushil K Sarna; Fiscal Year: 2010..abstract_text> ..
- Gastric Tube Placement in Young ChildrenMarsha Ellett; Fiscal Year: 2008..Results from this study will increase the safety of using gastric tubes in young children. ..
- Surveillance for Hepatocellular Carcinoma among HCV-infected VeteransHashem El Serag; Fiscal Year: 2009..Evaluating the extent and patterns of HCC surveillance is crucial in understanding diffusion (and obstacles) of this practice and in designing interventions to improve the implementation of HCC surveillance. ..
- Prenatal and Neonatal Biologic Markers for AutismLisa Croen; Fiscal Year: 2006..abstract_text> ..
- Gastrointestinal Biopsychosocial Research CenterWilliam Whitehead; Fiscal Year: 2008..The proposed Center is university wide and includes investigators from psychology, psychiatry, surgery (gynecology division), neuroradiology, dentistry, and the school of public health. [unreadable] [unreadable]..
- New Approach to Detect CP and Brain Injury by Term AgeRONALD ARIAGNO; Fiscal Year: 2003..It is essential to discover a new approach to identify brain injury early, before it will be possible to effectively investigate interventions that can improve neurological outcome of these high risk very premature infants. ..
- MUCOSAL T-CELLS IN EARLY&LATE PEDIATRIC CROHN'S DISEASESubra Kugathasan; Fiscal Year: 2005..abstract_text> ..
- Cognitive Modulation of Human Neuroendocrine Stress AxisJames Abelson; Fiscal Year: 2005..Existing animal data will be used to identify factors within the cognitive intervention which likely account for its potency and dismantling studies will be done to examine the separable effects of these factors. ..
- SEROTONIN'S ROLE IN PSYCHOBIOLOGY OF ANOREXIA NERVOSAEvelyn Attia; Fiscal Year: 2005..The long-term goal of this award is for the candidate to become an expert and independent researcher in the psychobiology of eating disorders, with special application to anorexia nervosa. ..
- REDUCING SERVICE USE IN OLDER PRIMARY CARE PATIENTSJoshua Klapow; Fiscal Year: 2003..2. Obtain training experiences that will facilitate the integration of research findings into the development and evaluation of geriatric primary care delivery systems. ..
- ANIMAL MODELS OF COLD AIR-INDUCED AIRWAY DISEASEMichael Davis; Fiscal Year: 2004..The investigators will use these same measurements to determine the changes in pulmonary mechanics and airway inflammation in dogs that perform repeated exercise in frigid environments. ..
- 14th Internatinal Symposium on Inherited DiseasesDavid Whitcomb; Fiscal Year: 2004..The format, venue, and content are designed to maximize participation, education, translation and implementation of the key elements of the many new findings in the genetics of the pancreas. ..
- Advancing the Treatment of Fecal & Urinary IncontinenceWilliam Whitehead; Fiscal Year: 2003..The conference is scheduled to take place November 3-5, 2002, in Milwaukee, and half of the invitees have accepted invitations to speak. ..
- Oral Tolerance: Mechanisms and ApplicationsLloyd Mayer; Fiscal Year: 2003....
- The Role of Food Viscosity in Calorie Intake RegulationTerry Davidson; Fiscal Year: 2005....
- SIMPLE VERTEBRATE AND INVERTEBRATE SYSTEMSMichael Gershon; Fiscal Year: 2005..Almost all trainees have continued to be productive in biomedical science and some have acquired leadership positions. ..
- Pharmacogenetics of MethadoneC Devane; Fiscal Year: 2003..This study will form the basis for subsequent studies which should provide a more rational basis for dosing of methadone in pregnant addicts. ..
- EVALUATION OF CHD IN MEN AND WOMEN PRIOR TO FIRST AMIBarbara Yawn; Fiscal Year: 2002..In addition, we will provide specific information on current gender-related practice patterns. This information can be used to inform future practice recommendations. ..
- Protection from Fas-mediated apoptosis in the gutMaria Abreu; Fiscal Year: 2002..The support from this R03 will permit me to successfully compete for an R01 and make the transition to an independent investigator. ..
- Development of the enteric nervous system: Cells & genesMichael Gershon; Fiscal Year: 2006..The invited speakers include all of the leading researchers in the field, including Professor Nicole Le Douarin. We also anticipate that many post-graduate students and post-doctoral fellows will also attend. [unreadable] [unreadable]..
- Gene Expression in Barrett's EsophagusHashem El Serag; Fiscal Year: 2006..We present preliminary data on microarray and RT-PCRanalyses on 5 patients with BE that suggest an overactive Wnt pathway: we have also assembled the essential components of a successful study using microarrays. ..
- The CNS and cirrhosis:psychobiological approachesCharmaine Stewart; Fiscal Year: 2006..Additionally, the proposed studies will be guided by a team of mentors and sponsors and supplemented by a didactic curriculum, all to lay the foundation for eventual independent clinical investigator status. ..
- MOLECULAR GENETICS OF HEREDITARY PANCREATITISDavid Whitcomb; Fiscal Year: 2008..The HP and familial pancreatitis studies are especially important because of the statistical power of family studies and the ability to detect modifier genes in a uniform background of susceptibility factors. ..
- Identification of Serum Markers of Liver Fibrogenesis/ Fibrolysis by ProteomicsDetlef Schuppan; Fiscal Year: 2008..Adaptation to the human proteome and prospective validation shall allow noninvasive monitoring of fibrosis progression and regression in patients with liver diseases. [unreadable] [unreadable] [unreadable]..
- Sphingosine Kinase Inhibitors as Anti-IBD AgentsLYNN MAINES; Fiscal Year: 2007..Upon the completion of these experiments, we will be ready to begin clinical testing of the single best drug candidate. [unreadable] [unreadable] [unreadable]..
- NAPS2 Continuation - Genome-Wide Association Study of PancreatitisDavid C Whitcomb; Fiscal Year: 2010..Knowledge of the genetic basis of pancreatitis will lead to new treatments, and help remove the stigma that chronic pancreatitis is only a disease of drunkards. ..
- Mouse Models for Celiac DiseaseDetlef Schuppan; Fiscal Year: 2007..g. by immunomodulatory cytokines or by cytokine antagonists. It is anticipated that the results will improve our understanding and management of cd and related autoimmune diseases. ..
- Regulation of spinal NK1R expression by chronic stressSylvie Bradesi; Fiscal Year: 2006..This proposal is expected to provide new insights into the mechanisms by which stress affects the processing of visceral nociception. ..
- Drug-Induced sudden death & ventricular arrhythmiaSean Hennessy; Fiscal Year: 2008..Finally, this project will create a valuable and lasting pharmacoepidemiologic data resource that can be brought to bear in future drug safety studies. [unreadable] [unreadable]..