photosensitizing agents

Summary

Summary: Drugs that are pharmacologically inactive but when exposed to ultraviolet radiation or sunlight are converted to their active metabolite to produce a beneficial reaction affecting the diseased tissue. These compounds can be administered topically or systemically and have been used therapeutically to treat psoriasis and various types of neoplasms.

Top Publications

  1. pmc Photodynamic therapy of cancer: an update
    Patrizia Agostinis
    Department of Molecular Cell Biology, Cell Death Research and Therapy Laboratory, Catholic University of Leuven, Belgium
    CA Cancer J Clin 61:250-81. 2011
  2. ncbi Riboflavin/ultraviolet-a-induced collagen crosslinking for the treatment of keratoconus
    Gregor Wollensak
    Department of Ophthalmology, Technical University of Dresden, Germany
    Am J Ophthalmol 135:620-7. 2003
  3. ncbi Stress-strain measurements of human and porcine corneas after riboflavin-ultraviolet-A-induced cross-linking
    Gregor Wollensak
    Department of Ophthalmology, Technical University of Dresden, Dresden, Germany
    J Cataract Refract Surg 29:1780-5. 2003
  4. ncbi Collagen crosslinking with riboflavin and ultraviolet-A light in keratoconus: long-term results
    Frederik Raiskup-Wolf
    Department of Ophthalmology, C G Carus University Hospital, Dresden, Germany
    J Cataract Refract Surg 34:796-801. 2008
  5. ncbi Safety of UVA-riboflavin cross-linking of the cornea
    Eberhard Spoerl
    Department of Ophthalmology, Universitatsklinikum Dresden, Dresden, Germany
    Cornea 26:385-9. 2007
  6. ncbi Photophysics and photochemistry of photodynamic therapy: fundamental aspects
    K Plaetzer
    Department of Molecular Biology, University of Salzburg, Hellbrunnerstrasse 34, 5020, Salzburg, Austria
    Lasers Med Sci 24:259-68. 2009
  7. pmc Photodynamic therapy: a new antimicrobial approach to infectious disease?
    Michael R Hamblin
    Wellman Laboratories of Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Photochem Photobiol Sci 3:436-50. 2004
  8. ncbi Gold nanorod-photosensitizer complex for near-infrared fluorescence imaging and photodynamic/photothermal therapy in vivo
    Boseung Jang
    Molecular Imaging and Therapy Branch, National Cancer Center, 111 Jungbalsan ro, Ilsandong gu, Goyang, Gyeonggi do 410 769, South Korea
    ACS Nano 5:1086-94. 2011
  9. ncbi Long-term results of riboflavin ultraviolet a corneal collagen cross-linking for keratoconus in Italy: the Siena eye cross study
    Aldo Caporossi
    Department of Ophthalmology and Neurosurgery, Santa Maria delle Scotte Hospital, Siena University, Siena, Italy
    Am J Ophthalmol 149:585-93. 2010
  10. ncbi Equivalence of biomechanical changes induced by rapid and standard corneal cross-linking, using riboflavin and ultraviolet radiation
    Silvia Schumacher
    IROC AG, Institute of Refractive and Ophthalmic Surgery, Stockerstrasse 37, Zurich, Switzerland
    Invest Ophthalmol Vis Sci 52:9048-52. 2011

Research Grants

Detail Information

Publications330 found, 100 shown here

  1. pmc Photodynamic therapy of cancer: an update
    Patrizia Agostinis
    Department of Molecular Cell Biology, Cell Death Research and Therapy Laboratory, Catholic University of Leuven, Belgium
    CA Cancer J Clin 61:250-81. 2011
    ..With a number of recent technological improvements, PDT has the potential to become integrated into the mainstream of cancer treatment...
  2. ncbi Riboflavin/ultraviolet-a-induced collagen crosslinking for the treatment of keratoconus
    Gregor Wollensak
    Department of Ophthalmology, Technical University of Dresden, Germany
    Am J Ophthalmol 135:620-7. 2003
    ..The aim of the present study was to evaluate the clinical usefulness of riboflavin/UVA-induced collagen crosslinking for bringing the progression of keratoconus to a halt...
  3. ncbi Stress-strain measurements of human and porcine corneas after riboflavin-ultraviolet-A-induced cross-linking
    Gregor Wollensak
    Department of Ophthalmology, Technical University of Dresden, Dresden, Germany
    J Cataract Refract Surg 29:1780-5. 2003
    ..To evaluate the biomechanical effect of combined riboflavin-ultraviolet A (UVA) treatment on porcine and human corneas...
  4. ncbi Collagen crosslinking with riboflavin and ultraviolet-A light in keratoconus: long-term results
    Frederik Raiskup-Wolf
    Department of Ophthalmology, C G Carus University Hospital, Dresden, Germany
    J Cataract Refract Surg 34:796-801. 2008
    ..To prove the long-term dampening effect of riboflavin- and ultraviolet-A-induced collagen crosslinking on progressive keratoconus...
  5. ncbi Safety of UVA-riboflavin cross-linking of the cornea
    Eberhard Spoerl
    Department of Ophthalmology, Universitatsklinikum Dresden, Dresden, Germany
    Cornea 26:385-9. 2007
    ..To study potential damage to ocular tissue during corneal collagen cross-linking (X-linking) by means of the riboflavin/UVA (370 nm) approach...
  6. ncbi Photophysics and photochemistry of photodynamic therapy: fundamental aspects
    K Plaetzer
    Department of Molecular Biology, University of Salzburg, Hellbrunnerstrasse 34, 5020, Salzburg, Austria
    Lasers Med Sci 24:259-68. 2009
    ..e. tumor-centered approach with a focus on the actual clinical requirements of the respective tumor type...
  7. pmc Photodynamic therapy: a new antimicrobial approach to infectious disease?
    Michael R Hamblin
    Wellman Laboratories of Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Photochem Photobiol Sci 3:436-50. 2004
    ....
  8. ncbi Gold nanorod-photosensitizer complex for near-infrared fluorescence imaging and photodynamic/photothermal therapy in vivo
    Boseung Jang
    Molecular Imaging and Therapy Branch, National Cancer Center, 111 Jungbalsan ro, Ilsandong gu, Goyang, Gyeonggi do 410 769, South Korea
    ACS Nano 5:1086-94. 2011
    ..This novel multifunctional nanomedicine may be useful for near-infrared fluorescence imaging and PTT/PDT in various cancers...
  9. ncbi Long-term results of riboflavin ultraviolet a corneal collagen cross-linking for keratoconus in Italy: the Siena eye cross study
    Aldo Caporossi
    Department of Ophthalmology and Neurosurgery, Santa Maria delle Scotte Hospital, Siena University, Siena, Italy
    Am J Ophthalmol 149:585-93. 2010
    ..To report the long-term results of 44 keratoconic eyes treated by combined riboflavin ultraviolet A collagen cross-linking in the first Italian open, nonrandomized phase II clinical trial, the Siena Eye Cross Study...
  10. ncbi Equivalence of biomechanical changes induced by rapid and standard corneal cross-linking, using riboflavin and ultraviolet radiation
    Silvia Schumacher
    IROC AG, Institute of Refractive and Ophthalmic Surgery, Stockerstrasse 37, Zurich, Switzerland
    Invest Ophthalmol Vis Sci 52:9048-52. 2011
    ..The authors evaluated whether a rapid treatment protocol (higher intensity and shorter irradiation time) could achieve the same increase in corneal stiffness as the currently used standard protocol...
  11. ncbi Parasurgical therapy for keratoconus by riboflavin-ultraviolet type A rays induced cross-linking of corneal collagen: preliminary refractive results in an Italian study
    Aldo Caporossi
    Department of Ophthalmological and Neurosurgical Sciences, Siena University, Siena, Italy
    J Cataract Refract Surg 32:837-45. 2006
    ..To assess the effectiveness of riboflavin-ultraviolet type A rays induced cross-linking of corneal collagen in reducing progression of keratoconus and in improving visual acuity in patients with progressive keratoconus...
  12. ncbi Molecular effectors of multiple cell death pathways initiated by photodynamic therapy
    Esther Buytaert
    Department of Molecular and Cell Biology, Faculty of Medicine, Catholic University of Leuven, Campus Gasthuisberg, Herestraat 49, B 3000, Leuven Belgium
    Biochim Biophys Acta 1776:86-107. 2007
    ..This review highlights recent developments aimed at deciphering the molecular interplay between cell death pathways as well as their possible therapeutic exploitation in photosensitized cells...
  13. ncbi Novel development of 5-aminolevurinic acid (ALA) in cancer diagnoses and therapy
    Masahiro Ishizuka
    SBI ALApromo Co, LTD Roppongi 1 6 1, Minato ku, Tokyo 106 6019, Japan
    Int Immunopharmacol 11:358-65. 2011
    ..In this review, the biological significance of heme metabolites, the mechanism of PpIX accumulation in tumor cells, and the therapeutic potential of ALA-induced PDT alone and combined with hyperthermia and immunotherapy are discussed...
  14. ncbi Photodynamic inactivation of multi-resistant bacteria (PIB) - a new approach to treat superficial infections in the 21st century
    Tim Maisch
    Department of Dermatology, University of Regensburg, Germany
    J Dtsch Dermatol Ges 9:360-6. 2011
    ..In this review the physical-chemical and biological basics of photo-dynamic inactivation of bacteria (PIB) will be discussed as well as the possible dermatological indications...
  15. pmc Effect of 5-aminolevulinic acid-based photodynamic therapy via reactive oxygen species in human cholangiocarcinoma cells
    Cy Hyun Kim
    National Research and Development Center for Hepatobiliary Cancer, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea
    Int J Nanomedicine 6:1357-63. 2011
    ..Furthermore, an increased amount of PpIX in HuCC-T1 cells induced increased production of ROS by irradiation, resulting in increased phototoxicity...
  16. ncbi PUVA-induced apoptosis involves mitochondrial dysfunction caused by the opening of the permeability transition pore
    Marcella Canton
    Dipartimento di Chimica Biologica, Universita di Padova, Viale Giuseppe Colombo 3, Italy
    FEBS Lett 522:168-72. 2002
    ..Thus, the involvement of reactive oxygen species in the onset of PUVA-induced apoptosis appears mostly related to psoralen photooxidation...
  17. ncbi Complement factor H and high-temperature requirement A-1 genotypes and treatment response of age-related macular degeneration
    Takashi Tsuchihashi
    Department of Ophthalmology, Saitama Medical University, Iruma, Saitama, Japan
    Ophthalmology 118:93-100. 2011
    ....
  18. ncbi Nanoparticles in photodynamic therapy: an emerging paradigm
    Dev Kumar Chatterjee
    Division of Bioengineering, National University of Singapore, 117574, Singapore
    Adv Drug Deliv Rev 60:1627-37. 2008
    ..Although several challenges remain before they can be adopted for clinical use, these active or second-generation PDT nanoparticles probably offer the best hope for extending the reach of PDT to regions deep in the body...
  19. ncbi The present and future role of photodynamic therapy in cancer treatment
    Stanley B Brown
    Centre for Photobiology and Photodynamic Therapy, School of Biochemistry and Microbiology, University of Leeds, UK
    Lancet Oncol 5:497-508. 2004
    ..Here, we review current use of PDT in oncology and look at its future potential as more selective photosensitising drugs become available...
  20. ncbi Collagen crosslinking with ultraviolet-A and hypoosmolar riboflavin solution in thin corneas
    Farhad Hafezi
    Institute for Refractive and Ophthalmic Surgery, Zurich, Switzerland
    J Cataract Refract Surg 35:621-4. 2009
    ..Preoperative swelling of the cornea safely broadens the spectrum of CXL indications to thin corneas that would otherwise not be eligible for treatment...
  21. ncbi Bio-distribution and subcellular localization of Hypericin and its role in PDT induced apoptosis in cancer cells
    Seyed Mohamed Ali
    Department of Medical Sciences, National Cancer Centre, 11 Hospital Drive, Singapore 169610
    Int J Oncol 21:531-40. 2002
    ..Since many photosensitizing agents in current clinical use have mitochondrial targets, HY may be a valuable addition to current protocols...
  22. ncbi Photodynamic antimicrobial chemotherapy (PACT)
    M Wainwright
    Department of Chemistry, University of Central Lancashire, Preston, UK
    J Antimicrob Chemother 42:13-28. 1998
    ..PACT is proposed as a potential, low-cost approach to the treatment of locally occurring infection...
  23. ncbi A randomized controlled trial of corneal collagen cross-linking in progressive keratoconus: preliminary results
    Christine Wittig-Silva
    Centre for Eye Research Australia, East Melbourne, Australia
    J Refract Surg 24:S720-5. 2008
    ..This prospective, randomized, controlled trial aims to provide evidence in relation to the efficacy and safety of corneal collagen cross-linking (CXL) in the management of progressive keratoconus...
  24. pmc Influence of multidrug efflux systems on methylene blue-mediated photodynamic inactivation of Candida albicans
    Renato A Prates
    Center for Lasers and Applications, IPEN CNEN SP, Sao Paulo, SP 05508 000, Brazil
    J Antimicrob Chemother 66:1525-32. 2011
    ....
  25. ncbi The role of apoptosis in response to photodynamic therapy: what, where, why, and how
    Nancy L Oleinick
    Department of Radiation Oncology and the CWRU UHC Ireland Comprehensive Cancer Center, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA
    Photochem Photobiol Sci 1:1-21. 2002
    ..necrotic pathway and for producing tumor ablation in conjunction with tissue-level mechanisms operating in vivo...
  26. ncbi Intracellular photodynamic therapy with photosensitizer-nanoparticle conjugates: cancer therapy using a 'Trojan horse'
    Martina E Wieder
    School of Chemical Sciences and Pharmacy, University of East Anglia, Norwich, UK NR4 7TJ
    Photochem Photobiol Sci 5:727-34. 2006
    ..Our results suggest that gold nanoparticle conjugates are an excellent vehicle for the delivery of surface bound hydrophobic photosensitizers for efficacious photodynamic therapy of cultured tumour cells...
  27. ncbi Ultraviolet A/riboflavin corneal cross-linking for infectious keratitis associated with corneal melts
    Hans Peter Iseli
    Institute of Refractive and Ophthalmic Surgery, Zurich, Switzerland
    Cornea 27:590-4. 2008
    ..To evaluate the efficacy of ultraviolet-corneal cross-linking (CXL) for treating infectious melting keratitis...
  28. ncbi Crosslinking treatment of progressive keratoconus: new hope
    Gregor Wollensak
    Department of Ophthalmology, Universitatsklinikum CGC, Dresden, Germany
    Curr Opin Ophthalmol 17:356-60. 2006
    ..Biomechanical measurements have shown an impressive increase in corneal rigidity of 328.9% in human corneas after crosslinking...
  29. ncbi Polycationic photosensitizer conjugates: effects of chain length and Gram classification on the photodynamic inactivation of bacteria
    Michael R Hamblin
    Wellman Laboratories of Photomedicine, Massachusetts General Hospital and Department of Dermatology, Harvard Medical School, Boston, MA 02114 2698, USA
    J Antimicrob Chemother 49:941-51. 2002
    ..In this report we explore the relationship between the size of the polylysine chain and its effectiveness for mediating the killing of Gram-negative and Gram-positive bacteria...
  30. ncbi State of the art in the delivery of photosensitizers for photodynamic therapy
    Yvette Niamien Konan
    University of Geneva, School of Pharmacy, CH 1211 Geneva 4, Switzerland
    J Photochem Photobiol B 66:89-106. 2002
    ..Specific targeting can also be achieved by binding of monoclonal antibodies or specific tumour-seeking molecules to PS or by the coating of PS loaded carriers...
  31. pmc Role of cytokines in photodynamic therapy-induced local and systemic inflammation
    S O Gollnick
    PDT Center, Roswell Park Cancer Institute, Elm and Carlton St, Buffalo, NY 14263, USA
    Br J Cancer 88:1772-9. 2003
    ..They also lay the mechanistic groundwork for further ongoing studies that attempt to optimise PDT through the modulation of the critical inflammatory mediators...
  32. ncbi The physics, biophysics and technology of photodynamic therapy
    Brian C Wilson
    Division of Biophysics and Bioimaging, Ontario Cancer Institute and Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada
    Phys Med Biol 53:R61-109. 2008
    ..The final section of the review introduces some new frontiers of research including low dose rate (metronomic) PDT, two-photon PDT, activatable PDT molecular beacons and nanoparticle-based PDT...
  33. ncbi Porphyrin and nonporphyrin photosensitizers in oncology: preclinical and clinical advances in photodynamic therapy
    Aisling E O'Connor
    UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Belfield, Dublin, Ireland
    Photochem Photobiol 85:1053-74. 2009
    ..The aim of this review is to provide an insight into PDT photosensitizers clinically approved for application in oncology, as well as those which show significant potential in ongoing preclinical studies...
  34. ncbi Collagen cross-linking in early keratoconus with riboflavin in a femtosecond laser-created pocket: initial clinical results
    Anastasios John Kanellopoulos
    Laservision gr Institute, Athens, Greece
    J Refract Surg 25:1034-7. 2009
    ..To evaluate the safety and efficacy of a novel femtosecond laser-assisted technique for intrastromal administration of riboflavin and higher fluence ultraviolet a (UVA) light in collagen cross-linking (CXL) for keratoconus...
  35. ncbi Current clinical and preclinical photosensitizers for use in photodynamic therapy
    Michael R Detty
    Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, New York 14260 3000, USA
    J Med Chem 47:3897-915. 2004
  36. ncbi Nanoparticles as vehicles for delivery of photodynamic therapy agents
    Denise Bechet
    Centre de Recherche en Automatique de Nancy, Nancy University, Vandoeuvre les Nancy, France
    Trends Biotechnol 26:612-21. 2008
    ..inorganic oxide-, metallic-, ceramic-, and biodegradable polymer-based nanomaterials as carriers of photosensitizing agents, are highlighted...
  37. ncbi A new strategy to destroy antibiotic resistant microorganisms: antimicrobial photodynamic treatment
    Tim Maisch
    Antimicrobial PDT, Clinic and Polyclinic for Dermatology, Regensburg University Hospital, Germany, Franz Josef Strauss Allee 11, 93053 Regensburg, Germany
    Mini Rev Med Chem 9:974-83. 2009
    ....
  38. ncbi Photodynamic therapy for endodontic disinfection
    Nikolaos S Soukos
    Applied Molecular Photomedicine Laboratory, The Forsyth Institute, Boston, Massachusetts 02115 3799, USA
    J Endod 32:979-84. 2006
    ..We conclude that PDT may be developed as an adjunctive procedure to kill residual bacteria in the root canal system after standard endodontic treatment...
  39. ncbi Evaluation of antibacterial efficacy of photo-activated riboflavin using ultraviolet light (UVA)
    Karim Makdoumi
    Department of Ophthalmology, Orebro University Hospital, Orebro, Sweden
    Graefes Arch Clin Exp Ophthalmol 248:207-12. 2010
    ..To evaluate the antibacterial efficacy of photo-activated riboflavin using Ultraviolet A (UVA) on three bacterial strains commonly detected in keratitis...
  40. ncbi Results of corneal collagen cross-linking in pediatric patients
    Ritu Arora
    Furu Nanak Eye Centre, New Delhi, India
    J Refract Surg 28:759-62. 2012
    ..To evaluate the safety and efficacy of corneal collagen cross-linking (CXL) in the treatment of keratoconus in pediatric patients...
  41. ncbi Photosensitizer encapsulated organically modified silica nanoparticles for direct two-photon photodynamic therapy and in vivo functional imaging
    Jun Qian
    Centre for Optical and Electromagnetic Research, Zhejiang Provincial Key Laboratory for Sensing Technologies, Zhejiang University, Hangzhou, Zhejiang 310058, PR China
    Biomaterials 33:4851-60. 2012
    ..Finally, we showed that the nanoprobes could target the subcutaneously xenografted tumor of a mouse for long time observations. ORMOSIL nanoparticles have great potentials for disease diagnosis and clinical therapies...
  42. pmc Stable synthetic cationic bacteriochlorins as selective antimicrobial photosensitizers
    Liyi Huang
    Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114 2696, USA
    Antimicrob Agents Chemother 54:3834-41. 2010
    ....
  43. pmc Photodynamic inactivation of Acinetobacter baumannii using phenothiazinium dyes: in vitro and in vivo studies
    Xavier Ragàs
    Institut Quimic de Sarria, Universitat Ramon Llull, Barcelona, Spain
    Lasers Surg Med 42:384-90. 2010
    ..However, their application in vivo has not extensively been explored. This study evaluates the bactericidal activity of phenothiazinium dyes against multidrug-resistant Acinetobacter baumannii both in vitro and in vivo...
  44. pmc Strategies to potentiate antimicrobial photoinactivation by overcoming resistant phenotypes
    Domingo Mariano Adolfo Vera
    Department of Chemistry, Facultad de Ciencias Exactas y Naturales, Universidad Nacional de Mar del Plata, Mar del Plata, Argentina
    Photochem Photobiol 88:499-511. 2012
    ..This review discusses the different antimicrobial PDT strategies and highlights the need for highly informative and comprehensive discovery approaches...
  45. ncbi Temoporfin (Foscan®, 5,10,15,20-tetra(m-hydroxyphenyl)chlorin)--a second-generation photosensitizer
    Mathias O Senge
    Medicinal Chemistry, Institute of Molecular Medicine, Trinity Centre for Health Sciences, Trinity College Dublin, St James s Hospital, Dublin 8, Ireland
    Photochem Photobiol 87:1240-96. 2011
    ..The literature has been covered up to early 2011...
  46. pmc Photodynamic therapy for infections: clinical applications
    Gitika B Kharkwal
    Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts, USA
    Lasers Surg Med 43:755-67. 2011
    ..This resurgence of interest has been partly motivated by the alarming increase in drug resistance amongst bacteria and other pathogens. This review will focus on the clinical applications of antimicrobial PDT...
  47. ncbi A NIR heptamethine dye with intrinsic cancer targeting, imaging and photosensitizing properties
    Xu Tan
    Institute of Combined Injury, State Key Laboratory of Trauma, Burns and Combined Injury, Chongqing Engineering Research Center for Nanomedicine, College of Preventive Medicine, Third Military Medical University, 30 Gaotanyan Road, Chongqing 400038, China
    Biomaterials 33:2230-9. 2012
    ..This dye may hold promise as a candidate multifunctional theranostic agent for future tumor targeted imaging and photodynamic therapy...
  48. ncbi Colorectal cancer cell detection by 5-aminolaevulinic acid-loaded chitosan nano-particles
    Shu Jyuan Yang
    Institute of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, No 1, Sec 1, Jen Ai Road, Taipei 100, Taiwan
    Cancer Lett 273:210-20. 2009
    ..This result implies that CNA could exclude the influence of normal flora inside the gut and serves as an adequate tool for fluorescent endoscopic detection of colorectal cancer cells in vivo...
  49. ncbi Fractional CO(2) laser-assisted drug delivery
    Merete Haedersdal
    Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Lasers Surg Med 42:113-22. 2010
    ..The purpose of this study was to evaluate drug delivery by CO(2) laser AFR using methyl 5-aminolevulinate (MAL), a porphyrin precursor, as a test drug...
  50. ncbi Modulation of central corneal thickness by various riboflavin eyedrop compositions in porcine corneas
    Jan M Vetter
    Department of Ophthalmology, University Medical Center, Johannes Gutenberg University Mainz, Mainz, Germany
    J Cataract Refract Surg 38:525-32. 2012
    ..To evaluate the modulatory effect of various riboflavin 0.1% and 0.2% compositions on the central corneal thickness (CCT) in fresh porcine corneas...
  51. ncbi Targeted photodynamic therapy for prostate cancer: inducing apoptosis via activation of the caspase-8/-3 cascade pathway
    Tiancheng Liu
    Department of Chemistry, Washington State University, Pullman, WA 99164 4630, USA
    Int J Oncol 36:777-84. 2010
    ..1. The demonstrated selective targeting and efficacy of this agent suggests that targeted PDT could serve as an alternative treatment option for prostate cancer...
  52. ncbi Histological examination of false positive tissue resection using 5-aminolevulinic acid-induced fluorescence guidance
    Satoshi Utsuki
    Department of Neurosurgery, Kitasato University School of Medicine, Kanagawa, Japan
    Neurol Med Chir (Tokyo) 47:210-3; discussion 213-4. 2007
    ..In contrast, all weak positive areas of recurrent malignant gliomas must be resected. Weak positive areas of the peritumoral edema surrounding metastatic brain tumors should be removed carefully as false positive results are common...
  53. pmc All you need is light: antimicrobial photoinactivation as an evolving and emerging discovery strategy against infectious disease
    Tyler G St Denis
    Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA, USA
    Virulence 2:509-20. 2011
    ....
  54. ncbi Complication and failure rates after corneal crosslinking
    Tobias Koller
    From Institut für Refraktive und Ophthalmo Chirurgie, Zurich, Switzerland
    J Cataract Refract Surg 35:1358-62. 2009
    ..To evaluate the complication rate of corneal crosslinking (CXL) for primary keratectasia and to develop recommendations for avoiding complications...
  55. ncbi Limitation of collagen cross-linking with hypoosmolar riboflavin solution: failure in an extremely thin cornea
    Farhad Hafezi
    Geneva University Hospitals, Geneva, Switzerland
    Cornea 30:917-9. 2011
    ..We report a case of failure of corneal collagen cross-linking (CXL) for progressive keratoconus after preoperative stromal swelling with hypoosmolar riboflavin solution in an extremely thin cornea...
  56. ncbi Collagen cross-linking (CCL) with sequential topography-guided PRK: a temporizing alternative for keratoconus to penetrating keratoplasty
    A John Kanellopoulos
    Laservision gr Institute, Athens, Greece
    Cornea 26:891-5. 2007
    ..To assess the effectiveness of ultraviolet A (UVA) irradiation-induced collagen cross-linking (CCL) on keratoconus (KC) progression...
  57. ncbi Dirty hands: photodynamic killing of human pathogens like EHEC, MRSA and Candida within seconds
    Anja Eichner
    Department of Dermatology, Regensburg University Hospital, 93053 Regensburg, Germany
    Photochem Photobiol Sci 12:135-47. 2013
    ..Being fast and effective, antimicrobial photodynamic applications might become acceptable as a tool for hand hygiene procedures and also in other skin areas...
  58. ncbi Combination of 10% EDTA, Photosan, and a blue light hand-held photopolymerizer to inactivate leading oral bacteria in dentistry in vitro
    T Maisch
    Department of Dermatology, University Medical Center Regensburg, Regensburg, Germany
    J Appl Microbiol 107:1569-78. 2009
    ....
  59. ncbi Corneal cross-linking with hypo-osmolar riboflavin solution in thin keratoconic corneas
    Frederik Raiskup
    Department of Ophthalmology, Carl Gustav Carus University Hospital, Dresden, Germany
    Am J Ophthalmol 152:28-32.e1. 2011
    ..To evaluate the 1-year results of keratoconic eyes with thin corneas that were treated by a hypo-osmolar riboflavin solution and ultraviolet A collagen cross-linking (CXL)...
  60. ncbi Antimicrobial photodynamic therapy on drug-resistant Pseudomonas aeruginosa-induced infection. An in vivo study
    Maria C E Hashimoto
    Center for Lasers and Applications, Institute of Energetic and Nuclear Researches, IPEN CNEN SP, Sao Paulo, SP, Brazil
    Photochem Photobiol 88:590-5. 2012
    ..Mice survival was increased on 24 h. Thus, this result suggests that aPDT may also be a novel prophylactic treatment in the care of burned patients...
  61. ncbi Triple-functional core-shell structured upconversion luminescent nanoparticles covalently grafted with photosensitizer for luminescent, magnetic resonance imaging and photodynamic therapy in vitro
    Xiao Fei Qiao
    Beijing National Laboratory for Molecular Sciences, State Key Laboratory of Rare Earth Materials Chemistry and Applications, PKU HKU Joint Laboratory in Rare Earth Materials and Bioinorganic Chemistry, Peking University, Beijing 100871, China
    Nanoscale 4:4611-23. 2012
    ..Compared with the clinical commercial contrast agent Gd-DTPA, the as-fabricated nanomaterial showed a comparable longitudinal relaxivities value (r(1)) and similar imaging effect...
  62. ncbi Combined transepithelial phototherapeutic keratectomy and corneal collagen cross-linking for progressive keratoconus
    George D Kymionis
    Institute of Vision and Optics IVO, Faculty of Medicine, University of Crete, Heraklion, Crete, Greece
    Ophthalmology 119:1777-84. 2012
    ....
  63. ncbi Hypericin in cancer treatment: more light on the way
    Patrizia Agostinis
    Division of Biochemistry, Faculty of Medicine, KULeuven, Leuven, Belgium
    Int J Biochem Cell Biol 34:221-41. 2002
    ..This review focuses on the more recent advances in the use of hypericin as a photodynamic agent and discusses the current knowledge on the signaling pathways underlying its photocytotoxic action...
  64. ncbi Precise detection of lymph node metastases in mouse rectal cancer by using 5-aminolevulinic acid
    Yasutoshi Murayama
    Department of Pathology and Cell Regulation, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Int J Cancer 125:2256-63. 2009
    ..c) 2009 uicc...
  65. pmc 5-aminolevulinic acid-incorporated poly(vinyl alcohol) nanofiber-coated metal stent for application in photodynamic therapy
    Jin Ju Yoo
    National Research and Development Center for Hepatobiliary Diseases, Pusan National University Yangsan Hospital, Gyeongnam 626 770, Korea
    Int J Nanomedicine 7:1997-2005. 2012
    ..For this purpose, 5-aminolevulinic acid (ALA) was incorporated into poly(vinyl alcohol) (PVA) nanofiber, and coated onto metal stents. Their efficacy was assessed in PDT towards HuCC-T1 CC cells...
  66. ncbi New two-photon activated photodynamic therapy sensitizers induce xenograft tumor regressions after near-IR laser treatment through the body of the host mouse
    Jean R Starkey
    Department of Microbiology, Montana State University, Bozeman, MT 59717, USA
    Clin Cancer Res 14:6564-73. 2008
    ..These experiments also evaluated effects of high-energy femtosecond pulsed laser irradiation on normal tissues and characterized the response of xenograft tumors to our PDT protocols...
  67. pmc Synthesis and properties of benzo[a]phenoxazinium chalcogen analogues as novel broad-spectrum antimicrobial photosensitizers
    James W Foley
    Rowland Institute at Harvard, Harvard University, Cambridge, Massachusetts 02142, USA
    J Med Chem 49:5291-9. 2006
    ..These data, taken with the findings of uptake and retention studies, suggest that the superior activity of selenium derivative 3 can be attributed to its much higher triplet quantum yield...
  68. pmc Photodynamic therapy with Pc 4 induces apoptosis of Candida albicans
    Minh Lam
    Department of Dermatology, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, OH, USA
    Photochem Photobiol 87:904-9. 2011
    ..These data indicate that Pc 4-PDT can induce apoptosis in C. albicans. Therefore, a better understanding of the process will be helpful, as PDT may become a useful treatment option for candidiasis...
  69. ncbi 5-aminolevulinic acid-conjugated gold nanoparticles for photodynamic therapy of cancer
    Maung Kyaw Khaing Oo
    Department of Chemical Engineering and Materials Science, Stevens Institute of Technology, Castle Point on Hudson, Hoboken, NJ 07030, USA
    Nanomedicine (Lond) 3:777-86. 2008
    ..Effective delivery of photosensitizer to target tumor cells that causes minimal damage to healthy cells is an important requirement in photodynamic therapy of cancer...
  70. ncbi Targeted photodynamic therapy via receptor mediated delivery systems
    Wesley M Sharman
    Department of Nuclear Medicine and Radiobiology, Faculty of Medicine, Universite de Sherbrooke, Quebec, Canada
    Adv Drug Deliv Rev 56:53-76. 2004
    ..This review discusses various PS bioconjugates that utilize these factors and summarizes the results obtained to date...
  71. ncbi Targeted photodynamic therapy of breast cancer cells using antibody-phthalocyanine-gold nanoparticle conjugates
    Tanya Stuchinskaya
    School of Chemistry, University of East Anglia, Norwich, Norfolk, UK
    Photochem Photobiol Sci 10:822-31. 2011
    ..Cellular experiments demonstrated that the nanoparticle conjugates selectively target breast cancer cells that overexpress the HER2 epidermal growth factor cell surface receptor, and that they are effective photodynamic therapy agents...
  72. ncbi Long-term results of salvage photodynamic therapy for patients with local failure after chemoradiotherapy for esophageal squamous cell carcinoma
    T Yano
    Division of Digestive Endoscopy and Gastrointestinal Oncology, National Cancer Center Hospital East, Kashiwa, Japan
    Endoscopy 43:657-63. 2011
    ..The aim of this study was to clarify the long-term results of salvage photodynamic therapy (PDT) for local failure...
  73. pmc Photodynamic therapy with a cationic functionalized fullerene rescues mice from fatal wound infections
    Zongshun Lu
    Wellman Center for Photomedicine, Massachusetts General Hospital, 40 Blossom Street, Boston, MA 02114, USA
    Nanomedicine (Lond) 5:1525-33. 2010
    ..We asked whether this high degree of in vitro activity would translate into an in vivo therapeutic effect in two potentially lethal mouse models of infected wounds...
  74. ncbi Photodynamic therapy: a review of the literature and image documentation
    Maria Cláudia Almeida Issa
    Universidade Federal Fluminense, Niteroi, RJ, Brasil
    An Bras Dermatol 85:501-11. 2010
    ..The most extensively studied photosensitizing agents for PDT are 5-aminolevulinic acid for the treatment of actinic keratosis and methyl-aminolevulinate, ..
  75. pmc Analysis of the bacterial heat shock response to photodynamic therapy-mediated oxidative stress
    Tyler G St Denis
    John Jay High School, Cross River, NY, USA
    Photochem Photobiol 87:707-13. 2011
    ..Induction of HSPs may be a mechanism whereby bacteria could become resistant to PDT and warrants the need for further study in the application of dual PDT-HSP-inhibition therapies...
  76. pmc Photodynamic therapy: novel third-generation photosensitizers one step closer?
    L B Josefsen
    Department of Chemistry, University of Hull, Kingston upon Hull, UK
    Br J Pharmacol 154:1-3. 2008
    ..The lack of tumour specificity may have a significant impact on the potential BAM-SiPc has in clinical PDT...
  77. ncbi Photodynamic therapy with BF-200 ALA for the treatment of actinic keratosis: results of a prospective, randomized, double-blind, placebo-controlled phase III study
    R M Szeimies
    Department of Dermatology, Regensburg University Hospital, Regensburg, Germany
    Br J Dermatol 163:386-94. 2010
    ..Different strategies are applied to overcome the chemical instability of ALA in solution and to improve skin penetration. A new stable nanoemulsion-based ALA formulation, BF-200 ALA, is currently in clinical development for PDT of AK...
  78. ncbi Oncologic photodynamic therapy photosensitizers: a clinical review
    Ron R Allison
    21st Century Oncology, Greenville, NC 27834 3764, USA
    Photodiagnosis Photodyn Ther 7:61-75. 2010
    ..Based on a clinical orientation the qualities of successful photosensitizers will be examined, how current drugs fare and potential future options explored...
  79. ncbi Strategies for enhanced photodynamic therapy effects
    Sarika Verma
    Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Photochem Photobiol 83:996-1005. 2007
    ....
  80. pmc Miconazole induces fungistasis and increases killing of Candida albicans subjected to photodynamic therapy
    Sara B Snell
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY, USA
    Photochem Photobiol 88:596-603. 2012
    ..The data suggest that miconazole could be used to increase the efficacy of PDT against C. albicans, and its mechanism of action is likely to be multifactorial...
  81. ncbi Respiratory deficiency enhances the sensitivity of the pathogenic fungus Candida to photodynamic treatment
    Yeissa Chabrier-Roselló
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY, USA
    Photochem Photobiol 84:1141-8. 2008
    ....
  82. ncbi The effect of photodynamic treatment combined with antibiotic action or host defence mechanisms on Staphylococcus aureus biofilms
    Antonella Di Poto
    University of Pavia, Department of Biochemistry, Viale Taramelli 3 b, Pavia 27100, Italy
    Biomaterials 30:3158-66. 2009
    ..The results suggest that PDT combined with vancomycin and the host defences may be a useful approach for the inactivation of staphylococcal biofilms adhering to medical implant surfaces...
  83. ncbi Phenothiazinium-based photobactericidal materials
    Mark Wainwright
    Liverpool School of Pharmacy and Chemistry, John Moores University, James Parsons Building, Byrom Street, Liverpool L3 3AF, UK
    J Photochem Photobiol B 84:227-30. 2006
    ..Such materials may be of use in surface disinfection/infection control in the healthcare milieu...
  84. ncbi Photodynamic therapy for unresectable cholangiocarcinoma
    Yutaka Tomizawa
    Department of Medicine, University of Pittsburgh Medical Center, 5230 Center Avenue, Pittsburgh, PA 15232, USA
    Dig Dis Sci 57:274-83. 2012
    ..PDT has also been reported to have a favorable outcome as adjuvant and neoadjuvant therapy for CC. Although accumulated data and local expertise are limited, PDT can be regarded as a standard palliative therapy for unresectable CC...
  85. ncbi Antibacterial photodynamic therapy using water-soluble formulations of hypericin or mTHPC is effective in inactivation of Staphylococcus aureus
    Victoria Engelhardt
    Department of Molecular Biology, University of Salzburg, Hellbrunnerstrasse 34, 5020, Salzburg, Austria
    Photochem Photobiol Sci 9:365-9. 2010
    ..We suggest both substances as promising candidates for treatment of staphylococcal infections in wounds with APDT...
  86. pmc Increasing damage to tumor blood vessels during motexafin lutetium-PDT through use of low fluence rate
    Theresa M Busch
    Department of Radiation Oncology, School of Medicine, University of Pennsylvania Philadelphia, Pennsylvania 19104, USA
    Radiat Res 174:331-40. 2010
    ..Further study of low fluence rate as a means to improve responses to PDT under conditions designed to predominantly damage vasculature is warranted...
  87. ncbi Effect of surfactant on 5-aminolevulinic acid uptake and PpIX generation in human cholangiocarcinoma cell
    Chung Wook Chung
    Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea
    Eur J Pharm Biopharm 80:453-8. 2012
    ..Cotreatment with the surfactant resulted in an increased intracellular ALA level, PpIX formation, and phototoxicity...
  88. ncbi Photodynamic therapy with BF-200 ALA for the treatment of actinic keratosis: results of a multicentre, randomized, observer-blind phase III study in comparison with a registered methyl-5-aminolaevulinate cream and placebo
    T Dirschka
    Private Dermatological Practice Centre, Wuppertal, Germany
    Br J Dermatol 166:137-46. 2012
    ..BF-200 ALA (Biofrontera Bioscience GmbH, Leverkusen, Germany) is a gel formulation of ALA with nanoemulsion for the treatment of AK which overcomes previous problems of ALA instability and improves skin penetration...
  89. ncbi Evaluation of the role of the pharmacological inhibition of Staphylococcus aureus multidrug resistance pumps and the variable levels of the uptake of the sensitizer in the strain-dependent response of Staphylococcus aureus to PPArg(2)-based photodynamic i
    Mariusz Grinholc
    Laboratory of Molecular Diagnostics, Intercollegiate Faculty of Biotechnology, Department of Biotechnology, University of Gdansk and Medical University of Gdansk, Gdansk, Poland
    Photochem Photobiol 86:1118-26. 2010
    ..However, neither the variable levels of the uptaken PS nor the pharmacological inhibition of NorA efflux pump explained such a phenomenon...
  90. ncbi Intravitreal injection of bevacizumab combined with verteporfin photodynamic therapy for choroidal neovascularization in age-related macular degeneration
    Bradley T Smith
    Barnes Retina Institute, St Louis, Missouri, USA
    Retina 28:675-81. 2008
    ..To report the outcome for eyes treated with intravitreal injection of bevacizumab combined with verteporfin photodynamic therapy (PDT) for choroidal neovascularization (CNV) in age-related macular degeneration (AMD)...
  91. ncbi The role of porphyrin chemistry in tumor imaging and photodynamic therapy
    Manivannan Ethirajan
    PDT Center, Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Chem Soc Rev 40:340-62. 2011
    ..The clinical status of certain selected PDT agents is also summarized (205 references)...
  92. pmc The antibacterial effect of photodynamic therapy in dental plaque-derived biofilms
    C R Fontana
    Applied Molecular Photomedicine Laboratory, The Forsyth Institute, Boston, MA 02115, USA
    J Periodontal Res 44:751-9. 2009
    ....
  93. ncbi Spatially resolved cellular responses to singlet oxygen
    Robert W Redmond
    Wellman Center for Photomedicine, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA
    Photochem Photobiol 82:1178-86. 2006
    ..These examples indicate that, indeed, spatially resolved responses to 'O2 occur in cells...
  94. ncbi Enhanced photodynamic activity of meso-tetra(4-hydroxyphenyl)porphyrin by incorporation into sub-200 nm nanoparticles
    Yvette Niamien Konan
    School of Pharmacy, University of Geneva, 30 quai E Ansermet, CH 1211 4, Geneva, Switzerland
    Eur J Pharm Sci 18:241-9. 2003
    ..The most important photocytotoxicity was observed with 50:50 PLGA nanoparticles allowing low drug doses and short drug administration-irradiation intervals for local photodynamic therapy...
  95. ncbi Photothermal sensitisation as a novel therapeutic approach for tumours: studies at the cellular and animal level
    Monica Camerin
    Department of Biology, University of Padova, Via Ugo Bassi 58 B, 35121 Padova, Italy
    Eur J Cancer 41:1203-12. 2005
    ....
  96. ncbi ALA and Photofrin fluorescence-guided resection and repetitive PDT in glioblastoma multiforme: a single centre Phase III randomised controlled trial
    M Sam Eljamel
    The Scottish Photodynamic Therapy Centre, Dundee DD1 9SY, UK
    Lasers Med Sci 23:361-7. 2008
    ..A multicentre randomized controlled trial is warranted to confirm these results...
  97. ncbi Characterization of the cell death modes and the associated changes in cellular energy supply in response to AlPcS4-PDT
    Kristjan Plaetzer
    Institute of Physics and Biophysics, University of Salzburg, Hellbrunnerstrasse 34, 5020 Salzburg, Austria
    Photochem Photobiol Sci 1:172-7. 2002
    ..Further, it is speculated that cells undergoing apoptosis in response to PDT might maintain a high ATP level long enough to complete the apoptotic program...
  98. pmc Photodynamic therapy for localized infections--state of the art
    Tianhong Dai
    Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114 2696, USA
    Photodiagnosis Photodyn Ther 6:170-88. 2009
    ..PDT is being clinically studied for other dermatological infections such as leishmaniasis and mycobacteria. Antimicrobial PDT will become more important in the future as antibiotic resistance is only expected to continue to increase...
  99. ncbi Methylene blue photoinactivation of RNA viruses
    Robert A Floyd
    Oklahoma Medical Research Foundation, Auburn University, Auburn, AL 36849, USA
    Antiviral Res 61:141-51. 2004
    ..MB photoinactivation of viruses show significant promise because the technology not only offers significant potency but the history of safe MB use in human therapy makes it attractive also...
  100. pmc Bactericidal activity of photocatalytic TiO(2) reaction: toward an understanding of its killing mechanism
    P C Maness
    The National Renewable Energy Laboratory, Golden, Colorado 80401 3393, USA
    Appl Environ Microbiol 65:4094-8. 1999
    ..coli cell membrane. Subsequently, essential functions that rely on intact cell membrane architecture, such as respiratory activity, were lost, and cell death was inevitable...
  101. ncbi The outcome of 5-ALA-mediated photodynamic treatment in melanoma cells is influenced by vitamin C and heme oxygenase-1
    Stefanie Grimm
    Institute of Nutrition, Friedrich Schiller University of Jena, Dornburger Strasse 24, Jena, Germany
    Biofactors 37:17-24. 2011
    ..However, further studies are necessary to investigate more antioxidants and other substances, which might affect the outcome of photodynamic treatment in cancer therapy...

Research Grants59

  1. Photodynamic therapy of oral candidiasis
    CONSTANTINE HAIDARIS; Fiscal Year: 2005
    ..Specific aim 1: To assess the efficacy of selected photosensitizing agents in PDT of a Candida albicans biofilm. la...
  2. EFFECT OF LASER RADIATION ON PERIODONTOPATHIC BACTERIA
    CLAY HENRY; Fiscal Year: 1990
    ..Also examined will be the influence during laser exposure of exogenous photosensitizing agents, molecular oxygen concentration, and bacterial species other than black-pigmented Bacteroides...
  3. PHTHALOCYANINE PDT--IN VIVO RESPONSES AND MECHANISMS
    Craig Elmets; Fiscal Year: 2004
    ..causes tumor destruction is essential if PDT protocols are to be optimized and if newer more effective photosensitizing agents are to be developed...
  4. SYMPOSIUM ON PHOTODYNAMIC THERAPY
    David Kessel; Fiscal Year: 1990
    ..The topic will be the use of photosensitizing agents for tumor eradication...
  5. Photothermal Sensitization of Biological Systems
    Michael Rodgers; Fiscal Year: 2003
    ..depositing heat spikes in biological material using near-IR high-peak-power lasers and strongly absorbing photosensitizing agents. In the first Specific Aim the investigators will seek to establish a predictive understanding of how the ..
  6. Conference on Photodynamic Therapy
    David Kessel; Fiscal Year: 2002
    ..The most recent PDT meeting, sponsored by the International Photodynamic Assn, has more than 600 participants. ..
  7. Promotion of PDT Induced phototoxicity by bile acids
    David Kessel; Fiscal Year: 2003
    ..In the former cell line, we also demonstrated that UDCA could promote the apoptotic response to photosensitizing agents that catalyze selective photodamage to the anti-apoptotic protein Bcl-2, but do not affect the pro-..
  8. Spectral-Encoding for Video-Rate Hemodynamic Tomography
    Brian Pogue; Fiscal Year: 2007
    ..abstract_text> ..
  9. Vacsular Remodeling and Effects of Angiogenic Inhibition in Diabetic Retinopathy
    Peter Kaiser; Fiscal Year: 2006
    ..The CAM continues to serve as a convenient testbed for ongoing development of fractal methods and for examination of effects of human regulators on angiogenesis and vascular remodeling. ..
  10. VIRUS PHOTOINACTIVATION--DIMETHYLMETHYLENE BLUE IN RBC
    Stephen Wagner; Fiscal Year: 2004
    ..abstract_text> ..
  11. Macrophage Targeted Photodynamic Therapy
    MICHAEL HAMBLIN; Fiscal Year: 2004
    ....
  12. Multifunctional low-density lipoprotein nanoplatforms
    Gang Zheng; Fiscal Year: 2008
    ..abstract_text> ..
  13. IMMUNOLOGICAL CONSEQUENCES OF TRANSFUSION
    Loren Fast; Fiscal Year: 2002
    ..abstract_text> ..
  14. Light dosimetry for esophageal photodynamic therapy
    Linda Jones; Fiscal Year: 2007
    ..As esophageal photodynamic therapy is improved, it is likely to be used more often as an alternative to esophagectomy. [unreadable] [unreadable] [unreadable]..
  15. Enhancing Photodynamic Therapy with COX-2 Inhibition
    Charles Gomer; Fiscal Year: 2007
    ..If our preliminary findings are confirmed by studies outlined in this proposal, adjunctive COX-2 inhibitor treatment could provide a safe and effective method for improving clinical PDT. [unreadable] [unreadable]..
  16. Multimodality in vivo Molecular Imaging for Prostate PDT
    Baowei Fei; Fiscal Year: 2007
    ..The proposed imaging strategy has great potential to enhance public health by improving diagnosis and therapy of cancer. ..
  17. The Role of Urokinase Receptor in Prostate Cancer Progression
    Inder Sehgal; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  18. HYALURONAN AND EPIDERMAL DIFFERENTIATION
    Edward Maytin; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  19. Radiopharmaceuticals for Tumor Imaging and Photodynamic Therapy
    Ravindra Pandey; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  20. Toll-Like Receptor-Complex in Intestinal Epith. Cells
    Maria Abreu; Fiscal Year: 2007
    ..The results of our studies have important implications for understanding host-microbial interactions and the inter-relationship between the innate and adaptive immune systems in the gut. ..
  21. Breast Tissue ablation by Conductive Heating
    Gal Shafirstein; Fiscal Year: 2007
    ..It can also be applied, through further research, to other types of cancers (e.g. lung, kidney, head and neck) that involve surgical resection of solid tumors. [unreadable] [unreadable] [unreadable]..
  22. Enhancing Photodynamic Therapy for Treating Kaposi's Sarcoma
    Charles Gomer; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  23. OXIDATIVE STRESS AND CATARACT FORMATION
    Shambhu D Varma; Fiscal Year: 2010
    ..Along with monitoring inhibition of lens opacification, mechanism of action of EP will be ascertained at the levels of morphology, histology, tissue metabolism and apoptotic changes. ..
  24. ENHANCEMENT OF PDT USING BIOLOGICAL RESPONSE MODIFIERS
    David A Bellnier; Fiscal Year: 2010
    ....
  25. Photodestruction of Ovarian Cancer: ErbB3 Targeted Aptamer Nanoparticle Conjugate
    Tayyaba Hasan; Fiscal Year: 2009
    ..abstract_text> ..
  26. Training Program in Molecular and Cellular Toxicology
    John Reiners; Fiscal Year: 2008
    ..It is envisioned that students with such training will be better equipped to pursue postdoctoral research at major research laboratories throughout the United States. ..
  27. Nonobiosensors for Probing Chemical Exposure and Metabolism Pathways of Individua
    Tuan Vo Dinh; Fiscal Year: 2009
    ....
  28. Photodynamic Therapy for Endodontic Disinfection
    NIKOLAOS SOUKOS; Fiscal Year: 2009
    ..Photodynamic therapy may be an adjunctive procedure to kill residual root canal bacteria after their sensitization with a photoactive drug and their subsequent exposure to light. ..
  29. Ultra-High-Throughput Screening (uHTS) Based on Surface*
    Tuan Vo Dinh; Fiscal Year: 2009
    ....
  30. ADVANCED MULTISPECTRAL IMAGING FOR MEDICAL DIAGNOSTICS
    Tuan Vo Dinh; Fiscal Year: 2005
    ..microelectroptics and molecular genetics and mouse studies. In addition, project personnel include a veterinarian at the University of Tennessee, and medical researchers with expertise in clinical studies at the TCSC. ..
  31. Assessment of Muscle Vascular Disease with Diffuse Light
    Guoqiang Yu; Fiscal Year: 2007
    ..The proposed, noninvasive, portable, and inexpensive optical technology may fill in this gap by providing multiple hemodynamic information and by enabling continuous measurements at the bed-side and in ambulatory care. ..
  32. Development/Bifunctional MR Agents/Diagnosis and Therapy
    Ravindra Pandey; Fiscal Year: 2007
    ..abstract_text> ..
  33. EXPERIMENTAL PHOTOIMMUNOTHERAPY OF OVARIAN CANCER
    Tayyaba Hasan; Fiscal Year: 2006
    ..It is expected that these studies will provide a measure of the efficacy of Lp. PIT in comparison with standard PDT and C225 immunotherapy and form the basis of clinical protocols in the future. ..
  34. Linkage Studies of Quantitative Ocular Traits
    Barbara Klein; Fiscal Year: 2006
    ..Subsequent follow-up with fine mapping of areas of interest in the genome is planned. ..
  35. Family Clustering of Incidence & Progression of Cataract
    Barbara Klein; Fiscal Year: 2003
    ..We currently have no funds to support the proposed analyses. We believe this project offers the possibility of examining important hypotheses in a large group of families in a population-based framework. ..
  36. Novel Approaches to the Assessment of Oral Mucosal Immu*
    Theresa Whiteside; Fiscal Year: 2003
    ..A better understanding of oral immunity in normal and HIV-infected mucosa is important for the development of new antiviral therapies, including oral antiviral vaccines. ..
  37. PHOTOSENSTIZATION MECHANISMS IN HYPOXIC MEDIA
    ROBERT REDMOND; Fiscal Year: 2003
    ..The ability of a PIRG to modulate between oxygen-dependent and independent photosensitization mechanisms in direct response to oxygen levels will be investigated. ..
  38. MicroCT for Imaging Small Animals
    Paul Acton; Fiscal Year: 2003
    ..In conclusion, a microCT system would provide essential structural data to complement functional SPECT data in small animals, and will greatly strengthen the quantitative aspects of this emerging molecular imaging technique. ..
  39. C/EDB BETA AND CHOP IN EPIDERMAL DIFFERENTIATION
    Edward Maytin; Fiscal Year: 2002
    ....
  40. NOVEL APPROACHES TO IMPROVE AND EXTEND PLATELET STORAGE
    Sherrill Slichter; Fiscal Year: 2001
    ....
  41. IRRADIANCE AND PHOTOBLEACHING METRICS IN ALA PDT
    Allan Oseroff; Fiscal Year: 2002
    ..3. Determine the irradiance-dependent formation of photoproducts or other endogenous photosensitizers, the changes in hemoglobin oxygenation, and the alterations in tissue optical properties. ..
  42. OXYGEN AND LIGHT DEPENDENCY OF PHOTODYNAMIC THERAPY
    Barbara Henderson; Fiscal Year: 2004
    ..Similarly, PDT destroyed tumor cells may provide tumor antigen to differentiating dendritic cells generated by preceding delivery of GM-CSF. ..
  43. Molecular Characterization of p53R2 in Head and Neck Ca
    Stuart Wong; Fiscal Year: 2004
    ..We will identify and characterize the frequency of p53R2 gene SNPs in HNSCC patients and test the hypothesis that p53R2 gene SNPs predict adverse normal tissue radiation effects in HNSCC patients treated with radiation. ..
  44. Molecular Patterning via Photocatalytic Nanolithography
    Jane Bearinger; Fiscal Year: 2005
    ..Document repeatable surface patterning of cells using photocatalysis and biocompatible surface chemistries 5. Demonstrate nanometer scale surface patterning with proteins and DNA ..
  45. DNA-Based Vaccines for Oral Carcnoma
    Theresa Whiteside; Fiscal Year: 2005
    ....
  46. Two-Photon Fluorescence Probe Development for in Vivo Spatial and Temporal Angiog
    KEVIN BELFIELD; Fiscal Year: 2008
    ..Such a breakthrough will afford a better understanding of disease processes and the mechanism of action of drugs and other species in vivo. [unreadable] [unreadable] [unreadable]..
  47. Computer Directed Photodynamic Therapy of Prostate Ca
    Jerzy Jankun; Fiscal Year: 2005
    ....
  48. 2004 Biophysical Discussion: Membrane Microdomains
    Kenneth Jacobson; Fiscal Year: 2004
    ..The format of the Biophysical Discussions is unique in its stress on discussion and prior preparation by the participants. ..
  49. ANTIESTROGEN-RECEPTOR INTERACTION WITH DNA
    Russell Hilf; Fiscal Year: 2005
    ..Overall, the plan is to determine how the ERa and ERb subtypes interact with natural EREs, various ligands, and with each other to regulate gene expression." ..
  50. Photosensitization of Oral Bacteria
    NIKOLAOS SOUKOS; Fiscal Year: 2004
    ..In the same biofilm models the photodynamic effects of the PS will be established and PW-enhanced photosensitization of periodontopathogens by the PS will be evaluated. ..
  51. Simultaneous dual isotope SPECT
    Paul Acton; Fiscal Year: 2001
    ....
  52. PROGRESSION OF NUCLEAR DENSITY OVER A 10-YEAR INTERVAL
    Barbara Klein; Fiscal Year: 2002
    ....
  53. Mobilization of Candida albicans Biofilms
    Peter Suci; Fiscal Year: 2007
    ..albicans biofilm communities, it will provide the basis for development of methods for screening for adjuvant agents that will inhibit dissemination of these fungal infections. [unreadable] [unreadable] [unreadable]..
  54. OCULAR MELANOMA
    Barbara Hawkins; Fiscal Year: 2003
    ..Standardized clinical and data collection procedures will be employed, and standardized forms will be used in all centers. Central training and certification of all study staff will be required. ..
  55. Fourth NEI Symposium on the Epidemiology of Eye Diseases and Vision Disorders
    Barbara Hawkins; Fiscal Year: 2007
    ..Guest editors from the Planning Committee will be responsible for peer review and other scientific editorial tasks for manuscripts submitted for publication in the special issue of the journal. ..