tricyclic antidepressive agents

Summary

Summary: Substances that contain a fused three-ring moiety and are used in the treatment of depression. These drugs block the uptake of norepinephrine and serotonin into axon terminals and may block some subtypes of serotonin, adrenergic, and histamine receptors. However the mechanism of their antidepressant effects is not clear because the therapeutic effects usually take weeks to develop and may reflect compensatory changes in the central nervous system.

Top Publications

  1. ncbi Antidepressant treatment with tianeptine reduces apoptosis in the hippocampal dentate gyrus and temporal cortex
    Paul J Lucassen
    Institute for Neurobiology, Faculty of Science, Swammerdam Institute for Life Sciences, University of Amsterdam, Kruislaan 320, 1098 SM Amsterdam, The Netherlands
    Biol Psychiatry 55:789-96. 2004
  2. ncbi Standards of laboratory practice: antidepressant drug monitoring. National Academy of Clinical Biochemistry
    M W Linder
    Department of Pathology and Laboratory Medicine, University of Louisville, KY 40292, USA
    Clin Chem 44:1073-84. 1998
  3. ncbi Antidepressant-like actions of an AMPA receptor potentiator (LY392098)
    X Li
    Eli Lilly and Co, Lilly Research Laboratories, Indianapolis, IN 46285 0510, USA
    Neuropharmacology 40:1028-33. 2001
  4. ncbi Neurobiology of mood, anxiety, and emotions as revealed by studies of a unique antidepressant: tianeptine
    B S McEwen
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10021, USA
    Mol Psychiatry 10:525-37. 2005
  5. ncbi Noradrenergic antidepressants: does chronic treatment increase or decrease nuclear CREB-P?
    D H Manier
    Department of Psychiatry and Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232 2647, USA
    J Neural Transm 109:91-9. 2002
  6. pmc Stress-induced changes in cerebral metabolites, hippocampal volume, and cell proliferation are prevented by antidepressant treatment with tianeptine
    B Czeh
    Division of Neurobiology, German Primate Center, 37077 Gottingen, Germany
    Proc Natl Acad Sci U S A 98:12796-801. 2001
  7. ncbi Structural plasticity and tianeptine: cellular and molecular targets
    B S McEwen
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10021, USA
    Eur Psychiatry 17:318-30. 2002
  8. ncbi Antidepressants and prolonged stress in rats modulate CAM-L1, laminin, and pCREB, implicated in neuronal plasticity
    D Laifenfeld
    Laboratory of Psychobiology, Department of Psychiatry, Rambam Medical Center and B Rappaport Faculty of Medicine, Technion ITT, POB 9649 Haifa, 31096, Israel
    Neurobiol Dis 20:432-41. 2005
  9. ncbi Repeated restraint stress facilitates fear conditioning independently of causing hippocampal CA3 dendritic atrophy
    C D Conrad
    Department of Psychology, Arizona State University, Tempe 85287 1104, USA
    Behav Neurosci 113:902-13. 1999
  10. ncbi Neurobiological and clinical effects of the antidepressant tianeptine
    Siegfried Kasper
    Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria
    CNS Drugs 22:15-26. 2008

Detail Information

Publications226 found, 100 shown here

  1. ncbi Antidepressant treatment with tianeptine reduces apoptosis in the hippocampal dentate gyrus and temporal cortex
    Paul J Lucassen
    Institute for Neurobiology, Faculty of Science, Swammerdam Institute for Life Sciences, University of Amsterdam, Kruislaan 320, 1098 SM Amsterdam, The Netherlands
    Biol Psychiatry 55:789-96. 2004
    ..Here, we investigated whether the antidepressant tianeptine would affect apoptosis in an animal model of depression, the psychosocially stressed tree shrew...
  2. ncbi Standards of laboratory practice: antidepressant drug monitoring. National Academy of Clinical Biochemistry
    M W Linder
    Department of Pathology and Laboratory Medicine, University of Louisville, KY 40292, USA
    Clin Chem 44:1073-84. 1998
    ..Standardized and rigorous laboratory practices contribute to improved therapeutic management...
  3. ncbi Antidepressant-like actions of an AMPA receptor potentiator (LY392098)
    X Li
    Eli Lilly and Co, Lilly Research Laboratories, Indianapolis, IN 46285 0510, USA
    Neuropharmacology 40:1028-33. 2001
    ..These findings indicate that biarylpropylsulfonamides, exemplified by LY392098, may represent a novel class of antidepressants...
  4. ncbi Neurobiology of mood, anxiety, and emotions as revealed by studies of a unique antidepressant: tianeptine
    B S McEwen
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10021, USA
    Mol Psychiatry 10:525-37. 2005
    ..Together with clinical data on the efficacy of tianeptine as an antidepressant, these actions offer insights into how compounds like tianeptine may be useful in the treatment of neurobiological features of depressive disorders...
  5. ncbi Noradrenergic antidepressants: does chronic treatment increase or decrease nuclear CREB-P?
    D H Manier
    Department of Psychiatry and Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232 2647, USA
    J Neural Transm 109:91-9. 2002
    ....
  6. pmc Stress-induced changes in cerebral metabolites, hippocampal volume, and cell proliferation are prevented by antidepressant treatment with tianeptine
    B Czeh
    Division of Neurobiology, German Primate Center, 37077 Gottingen, Germany
    Proc Natl Acad Sci U S A 98:12796-801. 2001
    ..These findings provide a cellular and neurochemical basis for evaluating antidepressant treatments with regard to possible reversal of structural changes in brain that have been reported in depressive disorders...
  7. ncbi Structural plasticity and tianeptine: cellular and molecular targets
    B S McEwen
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10021, USA
    Eur Psychiatry 17:318-30. 2002
    ..In studying these actions, we hope to better understand the molecular and cellular targets of action of tianeptine in relation to its role in influencing structural plasticity of the hippocampus...
  8. ncbi Antidepressants and prolonged stress in rats modulate CAM-L1, laminin, and pCREB, implicated in neuronal plasticity
    D Laifenfeld
    Laboratory of Psychobiology, Department of Psychiatry, Rambam Medical Center and B Rappaport Faculty of Medicine, Technion ITT, POB 9649 Haifa, 31096, Israel
    Neurobiol Dis 20:432-41. 2005
    ..Our findings suggest that noradrenergic-regulated plasticity genes such as CAM-L1, laminin, and CREB play an important role both in stress and in the treatment of depression...
  9. ncbi Repeated restraint stress facilitates fear conditioning independently of causing hippocampal CA3 dendritic atrophy
    C D Conrad
    Department of Psychology, Arizona State University, Tempe 85287 1104, USA
    Behav Neurosci 113:902-13. 1999
    ..These data argue that different neural substrates underlie spatial recognition memory and fear conditioning...
  10. ncbi Neurobiological and clinical effects of the antidepressant tianeptine
    Siegfried Kasper
    Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria
    CNS Drugs 22:15-26. 2008
    ..The neurobiological properties of tianeptine may provide an explanation not only for its antidepressant activity, but also for its anxiolytic effects in depressed patients and its lack of adverse effects on cognitive function and memory...
  11. ncbi Effects of antidepressants and benzodiazepine treatments on the dendritic structure of CA3 pyramidal neurons after chronic stress
    A M Magarinos
    The Rockefeller University, New York, NY 10021, USA
    Eur J Pharmacol 371:113-22. 1999
    ..These findings suggest that the synaptic availability of 5-HT is involved in the mechanism leading to stress-induced dendritic remodeling and supports the idea that the hippocampal inhibitory GABAergic tone may play a regulatory role...
  12. ncbi Preclinical research on stress, memory, and the brain in the development of pharmacotherapy for depression
    David M Diamond
    Neuroscience Program, Department of Psychology, University of South Florida, PCD 4118G, 4202 E Fowler Ave, Tampa, FL 33612, USA
    Eur Neuropsychopharmacol 14:S491-5. 2004
    ..We conclude with a synthesis of the preclinical and clinical literature on stress, memory, and tianeptine with the proposal that tianeptine should enhance HC-PFC memory-related processing in people under stress...
  13. ncbi Neuroprotective properties of tianeptine: interactions with cytokines
    F Plaisant
    INSERM E 9935, Hopital Robert Debre, 48 Bd Serurier, 75019 Paris, France
    Neuropharmacology 44:801-9. 2003
    ..Thus tianeptine has neuroprotective effects against hypoxia in tissue culture and against the deleterious effects of cytokines in cortex and white matter, but not against NMDA receptor-mediated excitotoxicity...
  14. ncbi Clinical and neurobiological effects of tianeptine and paroxetine in major depression
    Thomas Nickel
    Max Planck Institute of Psychiatry, Munich, Germany
    J Clin Psychopharmacol 23:155-68. 2003
    ..The normalization of the HPA system as a common mode of action of different antidepressants seems to be of special interest...
  15. ncbi Chronic administration of tianeptine balances lipopolysaccharide-induced expression of cytokines in the spleen and hypothalamus of rats
    Nathalie Castanon
    INRA INSERM U394 Neurobiologie Intégrative, Institut Francois Magendie, rue Camille Saint Saens, 33077 Bordeaux Cedex, France
    Psychoneuroendocrinology 29:778-90. 2004
    ..These results open new vistas in the pharmacological activity of tianeptine and provide further insights on the possible mechanisms of action involved in its neuroprotective properties...
  16. ncbi Involvement of AMPA receptor phosphorylation in antidepressant actions with special reference to tianeptine
    Per Svenningsson
    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, New York 10021, USA
    Eur J Neurosci 26:3509-17. 2007
    ....
  17. ncbi Pre-training administration of tianeptine, but not propranolol, protects hippocampus-dependent memory from being impaired by predator stress
    Adam M Campbell
    Medical Research, VA Hospital, 13000 Bruce B Downs Blvd, Tampa, FL, USA
    Eur Neuropsychopharmacol 18:87-98. 2008
    ..These findings indicate that treatment with tianeptine, unlike propanolol, provides an effective means with which to block the adverse effects of stress on cognitive functions of the hippocampus...
  18. ncbi Acute stress-mediated increases in extracellular glutamate levels in the rat amygdala: differential effects of antidepressant treatment
    Leah R Reznikov
    Department of Pharmacology, Physiology and Neuroscience, School of Medicine, University of South Carolina, 6439 Garners Ferry Rd, D40 Columbia, SC 29208, USA
    Eur J Neurosci 25:3109-14. 2007
    ....
  19. ncbi Deliberate self-harm and antidepressant drugs. Investigation of a possible link
    S Donovan
    School of Community Health Sciences, Division of Public Health Medicine and Epidemiology, University Hospital, Queen s Medical Centre, Nottingham
    Br J Psychiatry 177:551-6. 2000
    ..It is not clear if the frequency of deliberate self-harm (DSH) is the same in patients taking different pharmacological classes of antidepressant drugs...
  20. ncbi Gender differences in treatment response to sertraline versus imipramine in chronic depression
    S G Kornstein
    Department of Psychiatry, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298 0710, USA
    Am J Psychiatry 157:1445-52. 2000
    ..The authors examined gender differences in treatment response to sertraline, a selective serotonin reuptake inhibitor (SSRI), and to imipramine, a tricyclic antidepressant, in chronic depression...
  21. ncbi Cyclic antidepressants and the risk of sudden cardiac death
    Wayne A Ray
    Department of Preventive Medicine, Division of Pharmacoepidemiology, Vanderbilt University School of Medicine, A 1124 Medical Center North, Nashville, TN 37232, USA
    Clin Pharmacol Ther 75:234-41. 2004
    ..We thus sought to quantify the risk of sudden cardiac death among TCA users, according to dose, as well as among users of selective serotonin reuptake inhibitors (SSRIs)...
  22. ncbi cAMP response element-mediated gene transcription is upregulated by chronic antidepressant treatment
    J Thome
    Division of Molecular Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06508, USA
    J Neurosci 20:4030-6. 2000
    ....
  23. ncbi Suicidality scores during double-blind fluoxetine and desipramine treatment in Mexican Americans
    Anil Sharma
    J Clin Psychopharmacol 27:99-101. 2007
  24. ncbi Antidepressants and suicide mortality
    A Ohberg
    Department of Forensic Medicine, University of Helsinki, Finland
    J Affect Disord 50:225-33. 1998
    ..This paper presents a nationwide analysis of suicide mortality in Finland from 1990 to 1995, when the total use of antidepressants, especially that by selective serotonin reuptake inhibitors (SSRIs) expanded in the country...
  25. pmc Antidepressant treatment and the risk of fatal and non-fatal self harm in first episode depression: nested case-control study
    Carlos Martinez
    General Practice Research Database Division, Medicines and Healthcare products Regulatory Agency, London SW8 5NQ
    BMJ 330:389. 2005
    ....
  26. ncbi Antidepressants and suicide risk in the United States, 1985-1999
    Michael F Grunebaum
    Department of Neuroscience, New York State Psychiatric Institute, New York, NY 10032, USA
    J Clin Psychiatry 65:1456-62. 2004
    ..An association was hypothesized between the increase in the use of non-tricyclic antidepressant medications in the United States and the decline in the suicide rate during the years 1985-1999...
  27. ncbi The efficacy of spinal manipulation, amitriptyline and the combination of both therapies for the prophylaxis of migraine headache
    C F Nelson
    Center for Clinical Studies, Northwestern College of Chiropractic, Bloomington, MN 55431, USA
    J Manipulative Physiol Ther 21:511-9. 1998
    ..Migraine headache affects approximately 11 million adults in the United States. Spinal manipulation is a common alternative therapy for headaches, but its efficacy compared with standard medical therapies is unknown...
  28. ncbi A double-blind randomized controlled trial of topiramate and amitriptyline either alone or in combination for the prevention of migraine
    Kader Keskinbora
    Pain Clinic, Department of Anesthesiology, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul 34303, Turkey
    Clin Neurol Neurosurg 110:979-84. 2008
    ..In the present study, the efficacy and tolerability of amitriptyline and topiramate combination is examined in the prevention of migraine attacks, in comparison to the monotherapy of each drug...
  29. ncbi Differential effects of predator stress and the antidepressant tianeptine on physiological plasticity in the hippocampus and basolateral amygdala
    Rose Marie Vouimba
    Department of Psychology, University of South Florida, 4202 E Fowler Avenue, PCD 4118G, Tampa, FL 33620, USA
    Stress 9:29-40. 2006
    ..The work also provides insight into the actions of tianeptine with the finding that it enhanced electrophysiological measures of plasticity in the hippocampus and amygdala under stress, as well as non-stress, conditions...
  30. ncbi Treatment of chronic headache with antidepressants: a meta-analysis
    G E Tomkins
    Department of Medicine, Dwight David Eisenhower Army Medical Center, Augusta, Georgia, USA
    Am J Med 111:54-63. 2001
    ..CONCLUSION: Antidepressants are effective in preventing chronic headaches. Whether this is independent of depression and whether there are differences in efficacy by class of agent needs further study...
  31. ncbi Tianeptine: a review of its use in depressive disorders
    A J Wagstaff
    Adis International Limited, Mairangi Bay, Auckland, New Zealand
    CNS Drugs 15:231-59. 2001
    ..Hepatoxicity is rare. The dosage should be decreased in elderly patients and those with severe renal failure, but adjustment is not necessary in patients with alcoholism or hepatic impairment, or those undergoing haemodialysis...
  32. ncbi Enhancement of antidepressant potency by a potentiator of AMPA receptors
    Xia Li
    Neuroscience Discovery Research, Eli Lilly and Co, Lilly Research Laboratories, Corporate Center, Indianapolis, Indiana, USA
    Cell Mol Neurobiol 23:419-30. 2003
    ....
  33. ncbi Tianeptine and its enantiomers: effects on spatial memory in rats with medial septum lesions
    R G Morris
    Centre for Neuroscience, University of Edinburgh, Crichton Street, Edinburgh EH8 9LE, UK
    Neuropharmacology 41:272-81. 2001
    ..These results are discussed in relation to different effects that tianeptine may have on learning including its ability to block stress-induced dendritic re-modelling of the hippocampus...
  34. ncbi Synaptic plasticity and tianeptine: structural regulation
    E Fuchs
    Division of Neurobiology, German Primate Center, Kellnerweg 4, 37077 Gottingen, Germany
    Eur Psychiatry 17:311-7. 2002
    ....
  35. ncbi Switching to tianeptine in patients with antidepressant-induced sexual dysfunction
    Murad Atmaca
    Firat University, School of Medicine, Department of Psychiatry, Elazig, Turkey
    Hum Psychopharmacol 18:277-80. 2003
    ..7% of the patients were responders. The results suggest that switching to tianeptine appears to be useful for alleviating sexual dysfunction caused by other antidepressants...
  36. ncbi Antidepressants and public health in Iceland. Time series analysis of national data
    Tomas Helgason
    Faculty of Medicine, University of Iceland, Reykjavik, Iceland
    Br J Psychiatry 184:157-62. 2004
    ..Major depressive disorder is the second leading cause of disability-adjusted life-years in developed regions of the world and antidepressants are the third-ranking therapy class worldwide...
  37. ncbi Modulation of tianeptine on ion currents induced by inhibitory neurotransmitters in acutely dissociated dorsal raphe neurons of Sprague-Dawley rats
    Youn Jung Kim
    Department of Physiology, College of Medicine, Kyung Hee University, 1 Hoigi dong, Dongdaemoon gu, 130 701, Seoul, South Korea
    Eur Neuropsychopharmacol 12:417-25. 2002
    ..This action may increase the excitability of serotonergic neurons of the dorsal raphe...
  38. ncbi Chronic treatment with the antidepressant tianeptine attenuates lipopolysaccharide-induced Fos expression in the rat paraventricular nucleus and HPA axis activation
    Nathalie Castanon
    INRA INSERM U394, Neurobiologie Integrative, Institut Francois Magendie, rue Camille Saint Saens, 33077 Bordeaux Cedex, France
    Psychoneuroendocrinology 28:19-34. 2003
    ..These results open new vistas on the pharmacological activity of tianeptine and provide further insights on the action mechanisms of antidepressants in clinics...
  39. ncbi Chronic treatment with the atypical antidepressant tianeptine attenuates sickness behavior induced by peripheral but not central lipopolysaccharide and interleukin-1beta in the rat
    N Castanon
    INRA INSERM U394, Neurobiologie Integrative, Institut Francois Magendie, Bordeau, France
    Psychopharmacology (Berl) 154:50-60. 2001
    ..In this last case, however, the effect of antidepressants has been only studied on the effect of peripherally administered cytokines...
  40. ncbi Molecular mechanisms of neuroplasticity and pharmacological implications: the example of tianeptine
    Bruce S McEwen
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology Rockefeller University, New York, NY 10021, USA
    Eur Neuropsychopharmacol 14:S497-502. 2004
    ..Chronic treatment with the antidepressant tianeptine may prevent these effects in hippocampus and amygdala...
  41. ncbi Tianeptine and fluoxetine in major depression: a 6-week randomised double-blind study
    Vladimir Novotny
    Department of Psychiatry, Comenius University, Bratislava, Slovakia
    Hum Psychopharmacol 17:299-303. 2002
    ..In conclusion, both tianeptine and fluoxetine are effective and well-tolerated treatments for major depression...
  42. ncbi Efficacy and safety of tianeptine in major depression: evidence from a 3-month controlled clinical trial versus paroxetine
    Lionel Waintraub
    Service de Psychiatrie du Pr J D Guelfi, Centre Hospitalier Paul Brousse, Villejuif, France
    CNS Drugs 16:65-75. 2002
    ..Zopiclone use was assessed to provide an indirect evaluation of the possible hypnotic activity of both treatments...
  43. ncbi [A meta-analysis of randomized controlled trials of tianeptine versus SSRI in the short-term treatment of depression]
    J P Olie
    Département universitaire de psychiatrie, Hopital Sainte Anne, 7, rue Cabanis, 75014 Paris
    Encephale 29:322-8. 2003
    ..07 depending on the methodology) was found in favor of tianeptine. All in all, this study confirmed that tianeptine is at least as effective as SSRI, with a trend for a better acceptability profile in the treatment of depressed patients...
  44. ncbi The antidepressant tianeptine persistently modulates glutamate receptor currents of the hippocampal CA3 commissural associational synapse in chronically stressed rats
    Maarten H P Kole
    Division of Neurobiology, German Primate Center, Gottingen, Germany mhpkoledpz gwdg de
    Eur J Neurosci 16:807-16. 2002
    ..This novel signal transduction mechanism for tianeptine may provide a mechanistic resolution for its neuroprotective properties and, moreover, a pharmacological trajectory for its memory enhancing and/or antidepressant activity...
  45. ncbi Effects of tianeptine and mianserin on car driving skills
    F Ridout
    HPRU Medical Research Centre, University of Surrey, Egerton Road, Guildford GU2 5XP, UK
    Psychopharmacology (Berl) 154:356-61. 2001
    ..Previous studies suggest that tianeptine has a non-sedative side-effect profile, but its effects on everyday activities including car driving have not been fully explored...
  46. ncbi Class-selective drug detection: fluorescently-labeled calmodulin as the biorecognition element for phenothiazines and tricyclic antidepressants
    Phillip M Douglass
    Department of Chemistry, University of Kentucky, Lexington, Kentucky 40506 0055, USA
    Bioconjug Chem 13:1186-92. 2002
    ..This work represents a proof-of-concept assay for rapid, homogeneous detection of drugs employing binding proteins as the biorecognition element...
  47. ncbi Doxepin plasma concentrations: is there really a therapeutic range?
    S Leucht
    Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar der Technischen Universitat Munchen, Gernany
    J Clin Psychopharmacol 21:432-9. 2001
    ..Meanwhile, a preliminary working range of 50 to 250 ng/mL is proposed on the basis of critical reassessment of published data...
  48. ncbi Antidepressant treatment of chronic tension-type headache: a comparison between fluoxetine and desipramine
    Z Walker
    Department of Psychiatry and Behavioural Sciences, University College London (UK) Medical School, England
    Headache 38:523-8. 1998
    ....
  49. ncbi A meta-analysis of randomized controlled trials of tianeptine versus SSRI in the short-term treatment of depression
    S Kasper
    Department of General Psychiatry, University of Vienna, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    Eur Psychiatry 17:331-40. 2002
    ..07 depending on the methodology) was found in favor of tianeptine. All in all, this study confirmed that tianeptine is at least as effective as SSRI, with a trend for a better acceptability profile in the treatment of depressed patients...
  50. ncbi Metabotropic glutamate receptors and neuroadaptation to antidepressants: imipramine-induced down-regulation of beta-adrenergic receptors in mice treated with metabotropic glutamate 2/3 receptor ligands
    F Matrisciano
    Department of Human Physiology and Pharmacology, University of Rome La Sapienza, Rome, Italy
    J Neurochem 93:1345-52. 2005
    ....
  51. ncbi Toxicokinetics of nortriptyline and amitriptyline: two case reports
    E J F Franssen
    Department of Pharmacy, University Hospital, Vrije Universiteit, Amsterdam, The Netherlands
    Ther Drug Monit 25:248-51. 2003
    ..It also shows that a patient with a severe TCA overdose can still survive if he or she receives appropriate and quick supportive care, even if the prognostic markers QRS time, coma grade, and serum TCA levels predict poor outcome...
  52. ncbi Modafinil enhances the increase of extracellular serotonin levels induced by the antidepressant drugs fluoxetine and imipramine: a dual probe microdialysis study in awake rat
    Luca Ferraro
    Department of Clinical and Experimental Medicine, Section of Pharmacology, University of Ferrara, Italy
    Synapse 55:230-41. 2005
    ..These findings suggest a therapeutic potential of low doses of modafinil in the treatment of depression when combined with low doses of classical antidepressants, especially by increasing 5-HT transmission in cortical regions...
  53. ncbi Cortical alpha-adrenoceptor downregulation by tricyclic antidepressants in the rat brain
    M N Subhash
    Department of Neurochemistry, National Institute of Mental Health and Neurosciences, Post Box no 2900, Bangalore 560029, India
    Neurochem Int 43:603-9. 2003
    ..The region-specific downregulation of alpha1- and alpha2-adrenoceptors density, which occur after prolonged AD treatment, may underline the therapeutic mechanism of action...
  54. ncbi [Pharmacologic therapy of depression during pregnancy]
    Cesario Bellantuono
    Unità di Psicofarmacologia Clinica, Sezione di Psichiatria e Psicologia Clinica, Dipartimento di Medicina e Sanita Pubblica, Universita, Verona
    Recenti Prog Med 97:94-107. 2006
    ..Inconclusive findings emerge, so far, from the few longitudinal studies focusing on the long-term neurodevelopment outcome in children...
  55. ncbi Geriatric depression treatment in nonresponders to selective serotonin reuptake inhibitors
    Ellen M Whyte
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Clin Psychiatry 65:1634-41. 2004
    ....
  56. ncbi Antidepressant-like effects in various mice strains in the tail suspension test
    Nadège Ripoll
    Faculte de Medecine, EA 3256 Neurobiologie de l Anxiété et de la Dépression, BP 53508, 1 rue Gaston Veil, F44035 Nantes, Cedex 01, France
    Behav Brain Res 143:193-200. 2003
    ..Our results suggest that response to an antidepressant treatment is under control of genetic factors and that the strain of mouse is an important parameter to consider...
  57. ncbi [Evidence for psychopharmacological treatment of depression in children and adolescents?]
    Per Hove Thomsen
    Arhus Universitetshospital, Børne og Ungdomspsykiatrisk Hospital, Risskov
    Ugeskr Laeger 169:1289-94. 2007
    ..Emphasis is put on treatment with selective serotonin reuptake inhibitors as these are the best-documented agents in the treatment of depression in children and adolescents...
  58. ncbi Lithium addition in antidepressant-resistant depression: effects on platelet 5-HT, plasma 5-HT and plasma 5-HIAA concentration
    Tom K Birkenhager
    Department of Psychiatry, Erasmus Medical Centre, Rotterdam, The Netherlands
    Prog Neuropsychopharmacol Biol Psychiatry 31:1084-8. 2007
    ..The increments in 5-HIAA concentration during lithium addition are indicative of an increased 5-HT turnover...
  59. ncbi An intensive treatment program of interpersonal psychotherapy plus pharmacotherapy for depressed inpatients: acute and long-term results
    Elisabeth Schramm
    University Medical Center Freiburg, Department of Psychiatry, Hauptstrasse 5, 79104 Freiburg, Germany
    Am J Psychiatry 164:768-77. 2007
    ..The purpose of this article was to determine the relative efficacy of a psychotherapy program when combined with pharmacotherapy versus medication and clinical management in more severely depressed patients...
  60. ncbi [Review of antidepressants from the TCAs to the third generation drugs]
    János Almási
    Organon Hungary Kft, Orvosi Osztály, Budapest
    Neuropsychopharmacol Hung 6:185-94. 2004
    ..The main aim of this review is to give an objective approach to the psychiatrists in order to choose the best and optimal pharmaco-therapeutical method in their daily practice...
  61. ncbi Sequential changes in BDNF mRNA expression and synaptic levels of AMPA receptor subunits in rat hippocampus after chronic antidepressant treatment
    Rebeca Martinez-Turrillas
    Department of Pharmacology, School of Medicine, University of Navarra, Apartado 177, 31080 Pamplona, Spain
    Neuropharmacology 49:1178-88. 2005
    ..The results suggest that paroxetine, but not desipramine, enhances synaptic plasticity in the hippocampus by increasing BDNF mRNA expression, which determines a later AMPAR subunit trafficking to synaptic membranes...
  62. ncbi [1+1 or 2x1? Another form of dual antidepressive mechanism of action]
    Laszlo Lakatos
    Pszichiátriai magánrendelés, Szekesfehervar, Budapest
    Neuropsychopharmacol Hung 7:118-24. 2005
    ..The good clinical efficacy data of escitalopram may be explained by its unique dual serotonergic effect on serotonin transporter protein...
  63. ncbi Bi-phasic change in BDNF gene expression following antidepressant drug treatment
    A L Coppell
    University Department of Clinical Pharmacology, University of Oxford, Radcliffe Infirmary, Oxford OX2 6HE, UK
    Neuropharmacology 44:903-10. 2003
    ..Thus, in this study drugs interacting with the central 5-HT system altered BDNF expression but the effect was bi-phasic over the 24 h post drug period...
  64. ncbi Serotonin transporter residual availability during long-term antidepressant therapy does not differentiate responder and nonresponder unipolar patients
    Jonathan Cavanagh
    Division of Community Based Sciences, Institute of Neurological Sciences, Southern General Hospital, Glasgow, United Kingdom
    Biol Psychiatry 59:301-8. 2006
    ..Dopamine transporter (DAT) availability was also assessed in the same patients to examine the relationship between the two transporter systems...
  65. ncbi [Paroxetine versus clomipramine in female adolescents suffering from anorexia nervosa and depressive episode--a retrospective study on tolerability, reasons for discontinuing the antidepressive treatment and different outcome measurements]
    Markus Strobel
    Klinik und Poliklinik für Kinder und Jugendpsychiatrie und Psychotherapie der Julius Maximilian Universität Würzburg
    Z Kinder Jugendpsychiatr Psychother 32:279-89. 2004
    ....
  66. ncbi Safety of antidepressants in the elderly
    Barbara R Sommer
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305 5723, USA
    Expert Opin Drug Saf 2:367-83. 2003
    ..Drug interactions, side effects and particular challenges to the older patient will be described. The authors will then advise a general strategy for prescribing antidepressants...
  67. ncbi Are selective serotonin re-uptake inhibitors associated with an increased risk of self-harm by antidepressant overdose?
    D N Bateman
    Scottish Poisons Information Bureau NPIS Edinburgh, Royal Infirmary of Edinburgh, 51 Little France Crescent, EH10 4SA Edinburgh, Scotland
    Eur J Clin Pharmacol 60:221-4. 2004
    ..To investigate likelihood of self-harm by overdose with antidepressant drugs of different types by examining hospital admission data and poisons inquiries and relating them to prescribing...
  68. ncbi Use of antidepressant medications: are there differences in psychiatric visits among patient treatments in the Veterans Administration?
    Alaa Hamed
    Health Outcomes Technologies, Health Services Department, Boston University School of Public Health, Boston, Massachusetts 02118, USA
    Med Care 42:551-9. 2004
    ..Treatment guidelines affect evaluation. Second-line medications are usually prescribed to patients with higher utilization...
  69. ncbi Sustained effects of phenelzine and tranylcypromine on orthostatic challenge in antidepressant-refractory depression
    Joke H M Tulen
    J Clin Psychopharmacol 26:542-4. 2006
  70. ncbi Combining norepinephrine and serotonin reuptake inhibition mechanisms for treatment of depression: a double-blind, randomized study
    J Craig Nelson
    Department of Psychiatry, University of California San Francisco, 401 Parnassus Avenue, Box 0984 5, San Francisco, CA 94143, USA
    Biol Psychiatry 55:296-300. 2004
    ..The current study was undertaken as a proof of the concept that combining norepinephrine and serotonin reuptake inhibition would be more effective and act more rapidly than either drug alone...
  71. ncbi A 15-year follow-up study of patients with panic disorder
    Sven Andersch
    Department of Psychiatry, Institute of Clinical Neuroscience, Goteborg University, Gothenburg, Sweden
    Eur Psychiatry 18:401-8. 2003
    ..Panic disorder (PD) is generally regarded as a chronic condition with considerable variation in severity of symptoms...
  72. ncbi [Suspected depression]
    C Steinmann
    MMW Fortschr Med 148:58-9. 2006
  73. ncbi Optimization of solid-phase microextraction procedures for the determination of tricyclic antidepressants and anticonvulsants in plasma samples by liquid chromatography
    Marcelo Delmar Cantu
    Instituto de Quimica de Sao Carlos, Universidade de Sao Paulo, Trabalhador São Carlense Avenue, 400 CEP 13566 590 São Carlos, SP, Brazil
    Anal Bioanal Chem 386:256-63. 2006
    ..The off-line SPME/LC methodologies developed allow anticonvulsants and antidepressants analyses from therapeutic to toxic levels for therapeutic drug monitoring...
  74. ncbi Nitric oxide involvement in depression during interferon-alpha therapy
    Eiji Suzuki
    Department of Psychiatry, Kitasato University School of Medicine, 2 1 1 Asamizodai, Sagamihara, Kanagawa, 228 8520, Japan
    Int J Neuropsychopharmacol 6:415-9. 2003
    ..This, however, was not the case with the latter group or those who had no psychiatric symptoms. These results suggest nitric oxide involvement in at least some forms of IFN-alpha-induced depression...
  75. ncbi Calcineurin (protein phosphatase 2B) is involved in the mechanisms of action of antidepressants
    C Crozatier
    INSERM U 513, 8 rue de General Sarrail, 94000 Creteil, France
    Neuroscience 144:1470-6. 2007
    ..These results suggest that calcineurin-dependent dephosphorylation plays an important role in the mechanisms of action of antidepressants, providing a new starting point for developing improved therapeutic treatments for depression...
  76. ncbi Excess fatality from desipramine and dosage recommendations
    Yona Amitai
    Department of Mother, Child and Adolescent Health, Ministry of Health, Jerusalem, Israel
    Ther Drug Monit 26:468-73. 2004
    ..Such adjustments have been done for nortriptyline, but not for desipramine. The authors suggest that the high CFR of desipramine might be reduced by lowering its dose, therapeutic plasma level, and maximal pill content...
  77. ncbi Efficacy of the MCHR1 antagonist N-[3-(1-{[4-(3,4-difluorophenoxy)phenyl]methyl}(4-piperidyl))-4-methylphenyl]-2-methylpropanamide (SNAP 94847) in mouse models of anxiety and depression following acute and chronic administration is independent of hippocam
    D J David
    Center for Neurobiology and Behavior, Columbia University, New York, New York, USA
    J Pharmacol Exp Ther 321:237-48. 2007
    ....
  78. ncbi Are gender differences important for the clinical effects of antidepressants?
    Malene Grubbe Hildebrandt
    Department of Psycchiatry, Center for Depression Research, Odense University Hospital, Sdr Boulevard 29, DK 5000 Odense C, The Netherlands
    Am J Psychiatry 160:1643-50. 2003
    ..Gender differences in antidepressant treatment response, side effects, dropout rates, and plasma concentrations were examined in patients with major and predominantly melancholic depression...
  79. ncbi Effect of antidepressant drugs on 6-OHDA-treated mice in the FST
    F Chenu
    Neurobiologie de l anxiété et de la dépression, EA 3256, Faculte de Medecine, 1 rue Gaston Veil, 44035 Nantes Cedex, France
    Eur Neuropsychopharmacol 17:187-93. 2007
    ..It could then be suggested that antidepressant-like effect of selective serotonin reuptake inhibitors (paroxetine and citalopram) in the mice FST requires the activation of dopaminergic pathways to occur...
  80. ncbi Antidepressant-induced hepatotoxicity
    M Isabel Lucena
    Instituto de Farmacoepidemiología de la Universidad de Valladolid, Spain
    Expert Opin Drug Saf 2:249-62. 2003
    ..The potential for severe hepatotoxicity associated with nefazodone is stressed. Guidelines for therapy and prevention of antidepressant-induced hepatotoxicity are also discussed...
  81. ncbi [The use of antidepressants to treat depression in children and adolescents]
    H Desombre
    Unité de psychopathologie de l enfant et de l adolescent, Departement de Pediatrie, Hopital Edouard Herriot, place d Arsonval 69437 Lyon, Cedex 03, France
    Arch Pediatr 13:711-3. 2006
  82. ncbi Effect of combined administration of 5-HT1A or 5-HT1B/1D receptor antagonists and antidepressants in the forced swimming test
    Ewa Tatarczyńska
    Department of New Drug Research, Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, Cracow PL 31 343, Poland
    Eur J Pharmacol 487:133-42. 2004
    ..No interaction was observed between 5-HT(1A) or 5-HT(1B/1D) receptor antagonists and citalopram...
  83. ncbi Antidepressant medications: a review of the evidence for drug-induced sexual dysfunction
    S A Montgomery
    Department of Pharmacology, Imperial College School of Medicine, P O Box 8751, London W13 8WH, UK
    J Affect Disord 69:119-40. 2002
    ..However, there is little detailed information on the prevalence of drug-induced sexual dysfunction or the differences, if any, between available drugs. This article is a critical review of the literature in the area...
  84. ncbi [Applications and safety of modern antidepressants in patients with liver diseases]
    Wit Dubarek
    Z Wojewódzkiego Szpitala Neuropsychiatrycznego w Lublińcu
    Wiad Lek 60:28-33. 2007
    ..In the study we subjected to analysis literature referred to safety of SSRI's, venlafaxine, milnacipran, mirtazapine, nefazodone and trazodone in patients with the diagnosis of depression and concomitant hepatopathy...
  85. ncbi The guinea pig forced swim test as a new behavioral despair model to characterize potential antidepressants
    Karsten M Wicke
    Neuroscience Discovery Research, Abbott, 67008, Ludwigshafen, Germany
    Psychopharmacology (Berl) 195:95-102. 2007
    ..Behavioral despair is a model of high predictivity for antidepressant activity in murids. For some drug targets, guinea pigs exhibit a higher homology to their human counterparts compared to murids...
  86. ncbi Effects of antidepressant drugs on the activity of cytochrome P-450 measured by caffeine oxidation in rat liver microsomes
    W A Danie
    Department of Pharmacokinetics and Drug Metabolism, Institute of Pharmacology, Polish Academy of Sciences,
    Pol J Pharmacol 53:351-7. 2001
    ..In summary, CYP1A2 was distinctly inhibited by imipramine and amitriptyline, CYP3A by imipramine and fluoxetine, while other CYP isoenzymes (CYP2B and/or 2E1) by imipramine and fluoxetine...
  87. ncbi Antidepressants in the treatment of migraine headache
    Nestor C Punay
    The University of Oklahoma Health Sciences Center, Department of Neurology, 711 S L Young Boulevard, Oklahoma City, OK 73104, USA
    Curr Pain Headache Rep 7:51-4. 2003
    ..In patients who are depressed with severe migraine, a tricyclic antidepressant may treat both conditions; however, the addition of a newer atypical antidepressant may be needed...
  88. ncbi Increased sensitivity to antidepressants of D3 dopamine receptor-deficient mice in the forced swim test (FST)
    Gian Marco Leggio
    Department of Experimental and Clinical Pharmacology, University of Catania Medical School, 95125 Catania, Italy
    Eur Neuropsychopharmacol 18:271-7. 2008
    ....
  89. ncbi Behavioral and pharmacological validation of the gerbil forced-swim test: effects of neurokinin-1 receptor antagonists
    Tanya L Wallace-Boone
    Neuroscience Drug Discovery, Bristol Myers Squibb Pharmaceutical Research Institute, Wallingford, CT, USA
    Neuropsychopharmacology 33:1919-28. 2008
    ..Overall, these results suggest that the gerbil is an ideal species for use in the FST, and that this paradigm may have predictive validity for identifying novel antidepressant compounds...
  90. ncbi Antidepressants and suicidality: the basis of controversies
    Darko Marcinko
    Department of Psychiatry, University Hospital Zagreb, Kispaticeva 12, 10000 Zagreb, Croatia
    Psychiatr Danub 19:238-40. 2007
    ..In this review, the possible risk-benefit ratio has been estimated according to the use of selective serotonin reuptake inhibitors (SSRIs) antidepressants due to relevant psychobiological, clinical and epidemiologic data...
  91. ncbi Comparison of noradrenergic and serotonergic antidepressants in reducing immobility time in the tail suspension test
    J Fujishiro
    Department of Psychiatry, Yokohama City University School of Medicine, Yokohama, Japan
    Jpn J Pharmacol 85:327-30. 2001
    ..These results suggest that a prolonged tail suspension test results in functional changes in the noradrenergic and serotonergic systems and alters the sensitivity to antidepressants...
  92. ncbi Salmon calcitonin potentiates the analgesia induced by antidepressants
    M J Ormazabal
    Dpto Farmacologia, Fac Medicina, Universidad Complutense de Madrid, Avda Complutense s n, Ciudad Universitaria, 28040 Madrid, Spain
    Pharmacol Biochem Behav 68:125-33. 2001
    ....
  93. ncbi [Toxicity in overdoses with new antidepressive agents. A survey of records shows different severity symptoms for different agents]
    Mark Personne
    Giftinformationscentralen, Stockholm
    Lakartidningen 105:125-7. 2008
  94. ncbi Mouse strain differences in the unpredictable chronic mild stress: a four-antidepressant survey
    Ipek Yalcin
    Universite Francois Rabelais de Tours, France
    Behav Brain Res 193:140-3. 2008
    ..In conclusion, these results emphasize that BALB/c mice are more sensitive than Swiss mice for studying the effects of the UCMS model as well as for testing antidepressant-like properties...
  95. ncbi Psychological interventions for major depression in primary care: a meta-analytic review of randomized controlled trials
    Biancamaria Bortolotti
    Institute of Psychiatry, Bologna University, Viale C Pepoli, 5IT 40123 Bologna, Italy
    Gen Hosp Psychiatry 30:293-302. 2008
    ..The present meta-analysis was aimed at assessing currently available evidence on the topic...
  96. ncbi BNIP-3: a novel candidate for an intrinsic depression-related factor found in NG108-15 cells treated with Hochu-ekki-to, a traditional oriental medicine, or typical antidepressants
    Michihisa Tohda
    Division of Medicinal Pharmacology, Institute of Natural Medicine, University of Toyama, Sugitani, Toyama, Japan
    Neurosci Res 62:1-8. 2008
    ..These results suggest that BNIP-3 is a candidate for an intrinsic factor related to antidepressive effects and that Wakan-yaku theory may be useful for the identification of other intrinsic functional molecules...
  97. ncbi Beyond the iron mask: towards better recognition and treatment of depression associated with Parkinson's disease
    David J Burn
    Neurology, Regional Neurosciences Centre, Newcastle General Hospital, and University of Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom
    Mov Disord 17:445-54. 2002
    ..Several studies have suggested that depression in the PD patient is associated with a more rapid deterioration in cognitive and motor functions, perhaps as a surrogate marker for more extensive brainstem cell loss...
  98. ncbi An overview of the clinical efficacy of mirtazapine
    O Benkert
    Johannes Gutenberg University Mainz, Mainz, Germany
    Hum Psychopharmacol 17:S23-6. 2002
    ..The negative predictive value approached maximum values as early as week 2 with mirtazapine and week 3 with paroxetine. This suggests that the predictability of the response to treatment is better with mirtazapine than with paroxetine...
  99. ncbi Treating generalized anxiety disorder
    Jack M Gorman
    Department of Psychiatry, Mt Sinai School of Medicine, New York, NY 10029, USA
    J Clin Psychiatry 64:24-9. 2003
    ..Antidepressants like paroxetine and venlafaxine are not only effective antidepressants but also effective anxiolytics, thus implying their special ability to treat GAD and concurrent depression, even over the long-term...
  100. ncbi Antidepressant use and off-label prescribing in children and adolescents in Dutch general practice (2001-2005)
    Anita C Volkers
    NIVEL, Utrecht, The Netherlands
    Pharmacoepidemiol Drug Saf 16:1054-62. 2007
    ..To study the use of antidepressants in children and adolescents in Dutch general practice in 2001 and 2005 and to determine off-label prescribing...
  101. ncbi Nortriptyline for treatment-resistant depression
    Andrew A Nierenberg
    Depression Clinical and Research Program, Massachusetts General Hospital, Harvard Medical School, Boston, 02114, USA
    J Clin Psychiatry 64:35-9. 2003
    ..This study assesses the efficacy of nortriptyline for patients with treatment-resistant major depression...

Research Grants72

  1. PHARMACOGENETICS AND RESPONSE TO THERAPY IN OLDER ADULTS
    SUSAN HECKBERT; Fiscal Year: 2000
    ..This project will incorporate advances in molecular biology in the study of response to drug therapy for common conditions, with the goal of improving clinical care of the elderly. ..
  2. ANTIDEPRESSANT THERAPY FOR METHADONE-TREATED ADDICTS
    George Woody; Fiscal Year: 1980
    ..Plasma samples are also taken at specified intervals and an attempt will be made to correlate blood levels of the antidepressants with clinical response...
  3. S-Adenosyl Methionine(SAMe)Augmentation of SSRIs in MDD
    George Papakostas; Fiscal Year: 2008
    ..It is hoped that this project award will provide the critical fund of basic knowledge and practical experience necessary to aid the candidate in becoming an independent investigator in this area. ..
  4. ANTIDEPRESSANT TREATMENT OF MELANCHOLIA IN LATE LIFE
    Steven Roose; Fiscal Year: 2001
    ..Finally, The applicants expect HRQOL to show continued improvement during the continuation phase in euthymic patients and an advantage for the SSRI in HRQOL improvement due to a superior side effect profile. ..
  5. Comparative Effectiveness Study for Bipolar Disorder
    Andrew A Nierenberg; Fiscal Year: 2010
    ..The two treatments will be the second generation antipsychotic mood stabilizer quetiapine and the classic mood stabilizer lithium. In addition to quetiapine or lithium, participants can be treated with other medications as needed. ..
  6. Pharmacotherapy for Minor Depression
    Andrew Nierenberg; Fiscal Year: 2004
    ..The results of this study will have profound public health implications by improving our understanding of the efficacy of SJW and standard antidepressants for the treatment of MinorD. ..
  7. Controlled Study of SAMe vs.Escitalopram in Major Depressive Disorder
    Maurizio Fava; Fiscal Year: 2008
    ..Secondary aims are to assess the acute effects of SAMe or escitalopram vs. placebo on remission rates, quality of life, and psychosocial functioning. ..
  8. Development of Sensory/Pain-Selective Local Anesthetics
    Peter Gerner; Fiscal Year: 2006
    ..abstract_text> ..
  9. BUPROPION AS AN ADJUNCT TO THE NICOTINE PATCH PLUS CBT
    Maurizio Fava; Fiscal Year: 2003
    ....
  10. Pharmacotherapy for opioid and cocaine dependence
    Bruce Rounsaville; Fiscal Year: 2005
    ..4. To examine depression as a predictor of response. 5. To examine three month follow-up status after completing the treatment trial for continuation in treatment, abstinence from illicit drugs, and depressive symptoms. ..
  11. Combining Antidepressants to Hasten Remission from Depression
    Jonathan W Stewart; Fiscal Year: 2010
    ....
  12. FLUOXETINE AND BEHAVIOR THERAPY IN SOCIAL PHOBIA
    Jonathan Davidson; Fiscal Year: 2001
    ..Effective treatments can be a long way towards reducing the societal burden associated with the disorder. ..
  13. Can Longitudinal Population-Based Data Help to Personalize Depression Treatment?
    Gregory E Simon; Fiscal Year: 2010
    ..We propose a set of targeted methodologic studies to prepare for a multi-site research consortium focused on predicting response to specific depression treatments. ..
  14. NEUROIMAGING OF INHIBITION & STIMULANT RESPONSE IN ADHD
    Steven Pliszka; Fiscal Year: 2004
    ..5) We will control for effects of gender and age, in particular girls with ADHD may not show the same neurobiological mechanisms as boys. ..
  15. ECT IN CLOZAPINE REFRACTORY SCHIZOPHRENIA
    Georgios Petrides; Fiscal Year: 2003
    ..The results of the study will guide clinicians faced with the problem of how to treat patients who have not been helped by standard antipsychotic medications and do not show an adequate response to clozapine. ..
  16. Epidemiology and Care of Comorbid Obesity and Depression
    Gregory Simon; Fiscal Year: 2006
    ..weight loss, nutrient intake, physical activity, depressive symptoms, functional impairment and disability in the two groups of women with comorbid obesity and depression randomly assigned to the two different intervention programs ..
  17. PSYCHOBIOLOGY OF EATING BEHAVIOR IN EATING DISORDERS
    B Walsh; Fiscal Year: 2008
    ..Additional experiments will examine whether excitatory controls of eating, as reflected by sham feeding (i.e., consumption of non-caloric food) and by cue reactivity, are increased in patients with BN and BED. ..
  18. Short-Term vs Long-Term Treatment for GAD
    Karl Rickels; Fiscal Year: 2008
    ..12 months). The proposed study will provide much needed data, lacking from the literature, about the value of long term medication treatment of patients with a DSM-IV GAD diagnosis. ..
  19. Modeling Adherence to Psychotherapy for Depression
    Gregory Simon; Fiscal Year: 2009
    ..The proposed research is one component of an ongoing comprehensive program to understand and increase consumer demand for effective depression treatment. ..
  20. FLUOXETINE AFTER WEIGHT RESTORATION IN ANOREXIA NERVOSA
    B Walsh; Fiscal Year: 2004
    ..Outcome will be assessed on the basis of maintenance of weight and reduction in psychopathological symptoms characteristic of AN. ..
  21. The Development of An Eating Laboratory for Overweight Adolescents
    B Walsh; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  22. Region & Developmental Stage Specific Deletion of MeCP2 in Mouse Brain
    Lisa Monteggia; Fiscal Year: 2008
    ..The proposed studies should increase our understanding of the role of MeCP2 in mediating certain RTT associated behaviors as well as identify neural circuits that mediate these abnormalities. [unreadable] [unreadable] [unreadable]..
  23. KAVA KAVA IN GENERALIZED ANXIETY: A DOUBLE-BLIND TRIAL
    Jonathan Davidson; Fiscal Year: 2001
    ..It will also contribute towards providing an answer to what is rapidly becoming a major public health question, namely what can we reasonably expect herbal treatments to offer? ..
  24. D-Cycloserine Enhancement of Exposure in Social Phobia
    Mark H Pollack; Fiscal Year: 2010
    ..This study addresses an important public health issue by assessing an intervention that may lead to a more efficient and effective application of empirically based psychosocial interventions for the treatment of SAD. ..
  25. Enhancing CBT Adherence in Refractory Obsessive Compulsive Disorder with MI
    Helen Simpson; Fiscal Year: 2008
    ..During Years 2 and 3, we will conduct an open trial of this EX/RP+MI intervention in 24 EX/RP-resistant OCD outpatients who had a poor response to prior EX/RP treatment. [unreadable] [unreadable]..
  26. Pilot Trial of Peer Support for Bipolar Disorder
    Gregory Simon; Fiscal Year: 2006
    ..abstract_text> ..
  27. COMPARING THREE ELECTRODE PLACEMENTS TO OPTIMIZE ECT
    Georgios Petrides; Fiscal Year: 2005
    ..The results of this study will promote more effective and safer treatment of the most severely ill depressed patients. ..
  28. Improving Outcomes in Pharmacotherapy of Social Phobia
    Mark Pollack; Fiscal Year: 2009
    ..It thus directly addresses a critical public health issue that adversely affects a substantial proportion of the population. ..
  29. POPULATION-BASED MANAGEMENT OF DEPRESSION
    Gregory Simon; Fiscal Year: 2003
    ..e. 12-18 mos) Incremental cost and cost-effectiveness of each intervention program compared to care as usual. ..
  30. Imaging the Serotonin System in Obsessive-Compulsive Disorder
    Helen Simpson; Fiscal Year: 2009
    ..Data from this study will advance our understanding of the brain mechanisms of OCD and help build a neurobiological foundation for the development of better treatments for this disabling condition. ..
  31. IMPROVING THE OUTCOME OF PATIENTS WITH OCD
    Helen Simpson; Fiscal Year: 2004
    ..The long-term goal of this work is to improve the outcome of patients with OCD. ..
  32. MR SPECTROSCOPIC IMAGING DURING METHADONE MAINTENANCE
    Mark Pollack; Fiscal Year: 2002
    ....
  33. Pharmacotherapy for Minor Depression
    Robert Howland; Fiscal Year: 2004
    ..The results of this study will have profound public health implications by improving our understanding of the efficacy of SJW and standard antidepressants for the treatment of MinorD. ..
  34. MAINTENANCE FLUOXETINE IN POSTTRAUMATIC STRESS DISORDER
    Jonathan Davidson; Fiscal Year: 2001
    ..Health services and cost implications of such findings remain considerable, given the morbidity associated with PTSD. ..
  35. DRUG AND NON-DRUG TREATMENT OF SEVERE MIGRAINES
    Kenneth Holroyd; Fiscal Year: 2004
    ....
  36. Impact of Trauma of Terroist Attack on Bipolar Patients
    Mark Pollack; Fiscal Year: 2003
    ..abstract_text> ..
  37. Translational Research on Eating Disorders
    B Walsh; Fiscal Year: 2006
    ....
  38. NALTREXONE AND CBT FOR PATIENTS WITH ALCOHOLISM AND PTSD
    Edna Foa; Fiscal Year: 2008
    ..Therefore the findings from this study will be highly credible and should impact significantly on treatment recommendations for this impaired population. ..
  39. D-Cycloserine Enhancement of Exposure in Social Phobia
    Stefan G Hofmann; Fiscal Year: 2010
    ..This study addresses an important public health issue by assessing an intervention that may lead to a more efficient and effective application of empirically based psychosocial interventions for the treatment of SAD. ..
  40. GABA Medications for Tobacco Addiction
    Mehmet Sofuoglu; Fiscal Year: 2009
    ..The findings of this study will provide valuable information to develop new pharmacotherapies for smoking cessation. ..
  41. BIOBEHAVIORAL MECHANISMS OF DRUG REWARD AND ADDICTION
    WILLIAM CARLEZON; Fiscal Year: 2009
    ..Understanding mechanistic links between cocaine-induced adaptations in gene expression and adaptations in behavior may facilitate the development of novel treatments for cocaine addiction and craving. ..
  42. OCD Collaborative Genetics Association Study
    James T McCracken; Fiscal Year: 2010
    ..The results of these analyses will guide future molecular strategies to identify genes involved in the pathogenesis of OCD. The clinical and genotype data from the sample will be publicly available for OCD genetics research. ..
  43. Core symptoms and profiles in premenstrual syndrome
    Ellen Freeman; Fiscal Year: 2008
    ..Further information will contribute to improved health care for women in their reproductive years. [unreadable] [unreadable] [unreadable] [unreadable]..
  44. Identification and Therapy of Postpartum Depression
    Katherine L Wisner; Fiscal Year: 2010
    ..We have developed a multi-disciplinary team with expertise in clinical research with depressed and minority women and health services to address these needs. ..
  45. Neurobehavioral Changes in Pediatric Affective Disorder
    Neal Ryan; Fiscal Year: 2006
    ....
  46. Basic mechanisms of antidepressant augmentation
    Michael Newman; Fiscal Year: 2003
    ..These experiments will permit a comprehensive assessment of the role of serotonergic mechanisms in AD augmentation by T3 and an empirical basis for its use in the treatment of depression. ..
  47. Comorbid Disorders in Treatment of Opiate Dependence
    GERARDO GONZALEZ HADDAD; Fiscal Year: 2005
    ..This K23 research career award will enable me to start an academic career focusing on research in cocaine and opiate dependence and to develop a bridge between clinical trials and services research. ..
  48. SERTRALINE FOR ALCOHOL DEPENDENCE AND DEPRESSION
    Helen Pettinati; Fiscal Year: 2003
    ..Overall, this project will determine if combining pharmacotherapies results in a better response in comorbidly depressed alcoholics than either medication alone or placebo. ..
  49. Vascular depression and magnetic stimulation therapy
    Robert Robinson; Fiscal Year: 2005
    ..e. more atrophy lower response rate) and cognitive function. ..
  50. DAYTIME SLEEPINESS--PREVALENCE, CONSEQUENCES, AND RISKS
    Thomas Roth; Fiscal Year: 2003
    ..The important contribution of the present proposal is that it will be the first population-based study to use laboratory assessments, its consequences and risks to measure sleepiness. ..
  51. Mixed-Effects ZIP Models--Mental Health Service Research
    Robert Gibbons; Fiscal Year: 2004
    ..abstract_text> ..
  52. Improve Primary Care Management of Adolescent Depression
    Laura Richardson; Fiscal Year: 2008
    ....
  53. APOE QUALITY OF LIFE AND MEDICAL COSTS IN LATE LIFE
    Dan Blazer; Fiscal Year: 2002
    ..Cox proportional hazard, discrete time survival, and hierarchical linear modeling will be used according to the metric and distribution of the dependent variable. ..
  54. Pramipexole in Treatment-Resistant Depression
    Roy Perlis; Fiscal Year: 2007
    ..The proposed investigation and training program will provide critical skills, experience and data to aid the candidate in writing an R01 and becoming an independent investigator. ..
  55. Gradual vs Abrupt Cessation Treatment for Smoking
    John Hughes; Fiscal Year: 2007
    ..This study will be the first large, systematic test of gradual vs. abrupt cessation. ..
  56. HYPOGLYCEMIA AND AUTONOMIC NERVOUS SYSTEM FUNCTION
    Roy Freeman; Fiscal Year: 2007
    ..Thus, the broad long term objectives of the proposal are to fully understand the mechanisms and consequences of hypoglycemia associated autonomic failure with the ultimate goal of finding an efficacious treatment. ..
  57. FLUOXETINE & COGNITIVE BEHAVIOR THERAPY IN SOCIAL PHOBIA
    Edna Foa; Fiscal Year: 2001
    ....
  58. Central betal adrenergic receptors and behavior
    Han Ting Zhang; Fiscal Year: 2004
    ..This will lead to the better understanding of pathophysiology and pharmacotherapy of depression. ..
  59. PATIENT AND PUBLIC EDUCATION IN CANCER PAIN MANAGEMENT
    Betty Ferrell; Fiscal Year: 2002
    ..This course will impact 120 healthcare settings to improve pain management and quality of life in cancer patients and to establish model pain education programs for national dissemination. ..
  60. Reducing Barriers to Pain and Fatigue Management
    Betty Ferrell; Fiscal Year: 2009
    ....
  61. Vulvar vestibulitis trial: Desipramine-Lidocaine
    David Foster; Fiscal Year: 2006
    ..equally effective or is one superior to the other? Is there any benefit from combined local and systemic treatments? And finally, do genetic characteristics and tissue cytokine concentrations influence treatment response? ..
  62. Antidepressant Effect on Hippocampal Synaptogenesis
    Tibor Hajszan; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  63. End of Life Nursing Education through Graduate Programs
    Betty Ferrell; Fiscal Year: 2006
    ..This proposal includes extensive evaluation planned to monitor individual and institutional dissemination. ..
  64. ACTION - A CHF Trial Investigating Outcomes of Exercise
    CHRISTOPHER O CONNOR; Fiscal Year: 2008
    ..The trial will take place over 5 years with an initial 6 months for planning, training, and implementation; 3 years of enrollment; 1 year of follow-up; and 6 months for close out, analysis, and presentation. ..
  65. BRAIN PATHOPHYSIOLOGY IN ANXIETY DISORDERS
    GREGORY SULLIVAN; Fiscal Year: 2008
    ..Through such work, he seeks to contribute to the understanding of the pathophysiology of PD in order to suggest improved therapeutics for this devastating and underrecognized brain disorder. ..
  66. Oncology Nursing Education in End of Life Care
    Betty Ferrell; Fiscal Year: 2007
    ..This proposal includes extensive evaluation planned to monitor individual and institutional dissemination. [unreadable] [unreadable] [unreadable]..
  67. Emotion in Dementia
    Howard Rosen; Fiscal Year: 2004
    ....
  68. The Michigan Clinical Research Collaboratory
    Daniel Clauw; Fiscal Year: 2004
    ..Disseminate findings, tools, and strategies from this project to other re-engineered networks and Research Centers, and ultimately interface with a National Electronics Clinical Trials and Research (NECTAR) network...
  69. CHRONIC LOW BACK PAIN AS A MODEL OF FIBROMYALGIA
    Daniel Clauw; Fiscal Year: 2002
    ..abstract_text> ..
  70. Tryptophan Metabolism, Genes, and Major Depression
    David Steffens; Fiscal Year: 2007
    ..Results from this study will help inform future treatment studies using genetics and metabolomic technology. [unreadable] [unreadable] [unreadable]..