Summary: Drugs used to prevent SEIZURES or reduce their severity.

Top Publications

  1. ncbi Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen
    C J Phiel
    Howard Hughes Medical Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6148, USA
    J Biol Chem 276:36734-41. 2001
  2. ncbi Definition of drug resistant epilepsy: consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies
    Patrick Kwan
    Division of Neurology, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
    Epilepsia 51:1069-77. 2010
  3. pmc Neural KCNQ (Kv7) channels
    David A Brown
    Department of Pharmacology, University College London, London, UK
    Br J Pharmacol 156:1185-95. 2009
  4. ncbi Do women with pre-eclampsia, and their babies, benefit from magnesium sulphate? The Magpie Trial: a randomised placebo-controlled trial
    Douglas Altman
    Lancet 359:1877-90. 2002
  5. ncbi Brain inflammation in epilepsy: experimental and clinical evidence
    Annamaria Vezzani
    Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Epilepsia 46:1724-43. 2005
  6. ncbi NKCC1 transporter facilitates seizures in the developing brain
    Volodymyr I Dzhala
    Department of Neurology, School of Medicine, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, Colorado 80262, USA
    Nat Med 11:1205-13. 2005
  7. ncbi Modern management of epilepsy: a practical approach
    Christian E Elger
    Clinic for Epileptology, University Bonn, Bonn, Germany
    Epilepsy Behav 12:501-39. 2008
  8. ncbi Pentylenetetrazole induced changes in zebrafish behavior, neural activity and c-fos expression
    S C Baraban
    Epilepsy Research Laboratory, Department of Neurological Surgery, University of California, San Francisco, Box 0520, 503 Parnassus Avenue, San Francisco, CA 94143, USA
    Neuroscience 131:759-68. 2005
  9. ncbi Evaluation of transport of common antiepileptic drugs by human multidrug resistance-associated proteins (MRP1, 2 and 5) that are overexpressed in pharmacoresistant epilepsy
    Carlos Luna-Tortós
    Department of Pharmacology, Toxicology and Pharmacy, University of Veterinary Medicine, Bunteweg 17, D 30559 Hannover, Germany
    Neuropharmacology 58:1019-32. 2010
  10. ncbi Critical review of current animal models of seizures and epilepsy used in the discovery and development of new antiepileptic drugs
    Wolfgang Loscher
    Department of Pharmacology, Toxicology and Pharmacy, University of Veterinary Medicine, Hannover, Germany
    Seizure 20:359-68. 2011

Detail Information

Publications338 found, 100 shown here

  1. ncbi Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen
    C J Phiel
    Howard Hughes Medical Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6148, USA
    J Biol Chem 276:36734-41. 2001
    ..Based on these observations, we propose that inhibition of histone deacetylase provides a mechanism for valproic acid-induced birth defects and could also explain the efficacy of valproic acid in the treatment of bipolar disorder...
  2. ncbi Definition of drug resistant epilepsy: consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies
    Patrick Kwan
    Division of Neurology, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
    Epilepsia 51:1069-77. 2010
    ..The rationale behind the definition and the principles governing its proper use are discussed, and examples to illustrate its application in clinical practice are provided...
  3. pmc Neural KCNQ (Kv7) channels
    David A Brown
    Department of Pharmacology, University College London, London, UK
    Br J Pharmacol 156:1185-95. 2009
    ..Flupirtine is in use as a central analgesic; retigabine is under clinical trial as a broad-spectrum anticonvulsant and is an effective analgesic in animal models of chronic inflammatory and neuropathic pain...
  4. ncbi Do women with pre-eclampsia, and their babies, benefit from magnesium sulphate? The Magpie Trial: a randomised placebo-controlled trial
    Douglas Altman
    Lancet 359:1877-90. 2002
    b>Anticonvulsants are used for pre-eclampsia in the belief they prevent eclamptic convulsions, and so improve outcome. Evidence supported magnesium sulphate as the drug to evaluate.
  5. ncbi Brain inflammation in epilepsy: experimental and clinical evidence
    Annamaria Vezzani
    Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Epilepsia 46:1724-43. 2005
    ..The elucidation of this aspect may open new perspectives for the pharmacologic treatment of seizures...
  6. ncbi NKCC1 transporter facilitates seizures in the developing brain
    Volodymyr I Dzhala
    Department of Neurology, School of Medicine, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, Colorado 80262, USA
    Nat Med 11:1205-13. 2005
    ..Our results provide evidence that NKCC1 facilitates seizures in the developing brain and indicate that bumetanide should be useful in the treatment of neonatal seizures...
  7. ncbi Modern management of epilepsy: a practical approach
    Christian E Elger
    Clinic for Epileptology, University Bonn, Bonn, Germany
    Epilepsy Behav 12:501-39. 2008
    ..Potential advances in the management of epilepsy are briefly discussed. This short review summarizes the authors' how-to-do approach to the modern management of people with epilepsy...
  8. ncbi Pentylenetetrazole induced changes in zebrafish behavior, neural activity and c-fos expression
    S C Baraban
    Epilepsy Research Laboratory, Department of Neurological Surgery, University of California, San Francisco, Box 0520, 503 Parnassus Avenue, San Francisco, CA 94143, USA
    Neuroscience 131:759-68. 2005
    ..Therefore, zebrafish larvae represent a powerful new system to study the underlying basis of seizure generation, epilepsy and epileptogenesis...
  9. ncbi Evaluation of transport of common antiepileptic drugs by human multidrug resistance-associated proteins (MRP1, 2 and 5) that are overexpressed in pharmacoresistant epilepsy
    Carlos Luna-Tortós
    Department of Pharmacology, Toxicology and Pharmacy, University of Veterinary Medicine, Bunteweg 17, D 30559 Hannover, Germany
    Neuropharmacology 58:1019-32. 2010
    ..The data indicate that common AEDs are not substrates for human MRP1, MRP2 or MRP5, at least in the in vitro models used in this study...
  10. ncbi Critical review of current animal models of seizures and epilepsy used in the discovery and development of new antiepileptic drugs
    Wolfgang Loscher
    Department of Pharmacology, Toxicology and Pharmacy, University of Veterinary Medicine, Hannover, Germany
    Seizure 20:359-68. 2011
    ..To realize this goal, the molecular mechanisms of the next generation of therapies must necessarily evolve to include targets that contribute to epileptogenesis and pharmacoresistance in relevant epilepsy models...
  11. ncbi Valproate: a reappraisal of its pharmacodynamic properties and mechanisms of action
    W Loscher
    Department of Pharmacology, Toxicology and Pharmacy, School of Veterinary Medicine, Hannover, Germany
    Prog Neurobiol 58:31-59. 1999
    ..By the experimental observations summarized in this review, most clinical effects of valproate can be explained, although much remains to be learned at a number of different levels of valproate's mechanisms of action...
  12. ncbi Gabapentin for the symptomatic treatment of painful neuropathy in patients with diabetes mellitus: a randomized controlled trial
    M Backonja
    Department of Neurology, University of Wisconsin, Madison 53792, USA
    JAMA 280:1831-6. 1998
    ..Pain is the most disturbing symptom of diabetic peripheral neuropathy. As many as 45% of patients with diabetes mellitus develop peripheral neuropathies...
  13. ncbi P-Glycoprotein-mediated efflux of phenobarbital, lamotrigine, and felbamate at the blood-brain barrier: evidence from microdialysis experiments in rats
    Heidrun Potschka
    Department of Pharmacology, Toxicology, and Pharmacy, School of Veterinary Medicine, Bunteweg 17, D 30559, Hannover, Germany
    Neurosci Lett 327:173-6. 2002
  14. pmc Patterns of treatment response in newly diagnosed epilepsy
    M J Brodie
    Western Infirmary, Glasgow
    Neurology 78:1548-54. 2012
    ..To delineate the temporal patterns of outcome and to determine the probability of seizure freedom with successive antiepileptic drug regimens in newly diagnosed epilepsy...
  15. ncbi Antiepileptic drugs--best practice guidelines for therapeutic drug monitoring: a position paper by the subcommission on therapeutic drug monitoring, ILAE Commission on Therapeutic Strategies
    Philip N Patsalos
    Institute of Neurology The National Hospital for Neurology and Neurosurgery, London and The Chalfont Centre for Epilepsy, Chalfont St Peter, United Kingdom
    Epilepsia 49:1239-76. 2008
    ..g., in pregnancy, or when an interacting drug is added or removed); (6) to guide dose adjustments for AEDs with dose-dependent pharmacokinetics, particularly phenytoin...
  16. ncbi Perspectives of zebrafish models of epilepsy: what, how and where next?
    Adam Michael Stewart
    Department of Pharmacology and Neuroscience Program, Tulane University Medical School, 1430 Tulane Ave, New Orleans, LA 70112, USA
    Brain Res Bull 87:135-43. 2012
    ..Here, we discuss recent developments in using zebrafish models to study the seizure-like behavior involved in epilepsy, outlining current challenges and strategies for further translational research in this field...
  17. ncbi Children's access to treatment for epilepsy: experience from the Lao People's Democratic Republic
    Hubert Barennes
    Francophone Institute for Tropical Medicine, Vientiane, Lao PDR
    Arch Dis Child 96:309-13. 2011
    ..Improving understanding of epilepsy and its treatment, will improve the treatment gap for epileptic children in the Lao PDR...
  18. ncbi Early control of seizures improves long-term outcome in children with tuberous sclerosis complex
    Roberta Bombardieri
    Department of Neurosciences, Pediatric Neurology Unit, Tor Vergata University, Via Montpellier 1, Rome 00133, Italy
    Eur J Paediatr Neurol 14:146-9. 2010
    ..Early control of seizures has a crucial role in preventing subsequent epileptic encephalopathy, and in reducing the cognitive/behavioural consequences of seizures, but does not guarantee for a normal mental outcome in children with TSC...
  19. ncbi Clinical aspects and biological bases of drug-resistant epilepsies
    G Regesta
    Department of Neurology, Epilepsy Center, San Martino Hospital, Genova, Italy
    Epilepsy Res 34:109-22. 1999
    ..Such hypotheses need to be confirmed with suitable experimental models of intractable epilepsy that are specifically dedicated, which have until now been lacking...
  20. pmc Ethosuximide, valproic acid, and lamotrigine in childhood absence epilepsy
    Tracy A Glauser
    Comprehensive Epilepsy Center, Division of Neurology, Cincinnati Children s Hospital, 3333 Burnet Ave, MLC 2015, Cincinnati, OH 45229, USA
    N Engl J Med 362:790-9. 2010
    ..Childhood absence epilepsy, the most common pediatric epilepsy syndrome, is usually treated with ethosuximide, valproic acid, or lamotrigine. The most efficacious and tolerable initial empirical treatment has not been defined...
  21. ncbi Animal models of epilepsy for the development of antiepileptogenic and disease-modifying drugs. A comparison of the pharmacology of kindling and post-status epilepticus models of temporal lobe epilepsy
    Wolfgang Loscher
    Department of Pharmacology, Toxicology, and Pharmacy, School of Veterinary Medicine, Bunteweg 17, Hannover, Germany
    Epilepsy Res 50:105-23. 2002
  22. ncbi Comparing the General Practice Research Database and the UK Epilepsy and Pregnancy Register as tools for postmarketing teratogen surveillance: anticonvulsants and the risk of major congenital malformations
    Rachel A Charlton
    Department of Pharmacy and Pharmacology, University of Bath, Bath, UK
    Drug Saf 34:157-71. 2011
  23. pmc Adverse antiepileptic drug effects: toward a clinically and neurobiologically relevant taxonomy
    Piero Perucca
    Department of Neurology, Columbia University, New York, NY, USA
    Neurology 72:1223-9. 2009
    ..This study aimed to define specific patterns of AE occurrence and determine their clinical relevance based on their association with subjective health status...
  24. ncbi ABCB1 polymorphisms influence the response to antiepileptic drugs in Japanese epilepsy patients
    Takayuki Seo
    Kumamoto University, Division of Pharmacology and Therapeutics, Graduate School of Medical and Pharmaceutical Sciences, Oe honmachi 5 1, Kumamoto 862 0973, Japan
    Pharmacogenomics 7:551-61. 2006
    ..Our objective was to investigate the effect of ABCB1 polymorphisms on AED responsiveness and on the pharmacokinetics of carbamazepine (CBZ) in epileptic patients with the indication for CBZ therapy...
  25. ncbi Perampanel, a selective, noncompetitive α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor antagonist, as adjunctive therapy for refractory partial-onset seizures: interim results from phase III, extension study 307
    Gregory L Krauss
    Johns Hopkins University, Baltimore, Maryland, USA
    Epilepsia 54:126-34. 2013
    ..To evaluate safety, tolerability, and seizure outcome data during long-term treatment with once-daily adjunctive perampanel (up to 12 mg/day) in patients with refractory partial-onset seizures...
  26. ncbi [How neuropathic is sciatica? The mixed pain concept]
    R Baron
    Klinik fur Neurologie, Universitatsklinikum Schleswig Holstein, Campus Kiel
    Orthopade 33:568-75. 2004
    ..e., antidepressants such as amitriptyline and anticonvulsants such as gabapentin, carbamazepine, and pregabalin...
  27. ncbi Central nervous system-active medications and risk for falls in older women
    Kristine E Ensrud
    Department of Medicine, Veterans Affairs Medical Center, Minneapolis, Minnesota, USA
    J Am Geriatr Soc 50:1629-37. 2002
    To determine whether current use of central nervous system (CNS)-active medications, including benzodiazepines, antidepressants, anticonvulsants, and narcotics, increases the risk for subsequent falls.
  28. ncbi Association of non-adherence to antiepileptic drugs and seizures, quality of life, and productivity: survey of patients with epilepsy and physicians
    Collin A Hovinga
    University of Tennessee Health Science Center, Memphis, TN 38103, USA
    Epilepsy Behav 13:316-22. 2008
  29. ncbi Modern antiepileptic drug development has failed to deliver: ways out of the current dilemma
    Wolfgang Loscher
    Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine, Hannover, Germany
    Epilepsia 52:657-78. 2011
    ..In this respect, the authors of this critical review will discuss several new ideas that may hopefully lead to more efficacious drug treatment of epilepsy in the future...
  30. ncbi Genome-wide association study identifies HLA-A*3101 allele as a genetic risk factor for carbamazepine-induced cutaneous adverse drug reactions in Japanese population
    Takeshi Ozeki
    Research Group for Pharmacogenomics, RIKEN Center for Genomic Medicine, Yokohama 230 0045, Japan
    Hum Mol Genet 20:1034-41. 2011
    ..Our findings should provide useful information for making a decision of individualized medication of anticonvulsants.
  31. ncbi Potential role of multidrug resistant proteins in refractory epilepsy and antiepileptic drugs interactions
    Alberto Lazarowski
    Facultad de Farmacia y Bioquimica, Instituto de Investigaciones en Fisiopatología y Bioquímica Clínica INFIBIOC, Universidad de Buenos Aires, Buenos Aires, Argentina
    Drug Metabol Drug Interact 26:21-6. 2011
    ..And in this regard, perhaps we can postulate to P-gp as a new clinical therapeutic target in multidrug-refractory epilepsy...
  32. ncbi A novel anti-epileptic agent, perampanel, selectively inhibits AMPA receptor-mediated synaptic transmission in the hippocampus
    Laura Ceolin
    MRC Centre for Synaptic Plasticity, School of Physiology and Pharmacology, University of Bristol, Bristol BS8 1TD, United Kingdom
    Neurochem Int 61:517-22. 2012
    ..The concentrations of perampanel required to reduce AMPA receptor-mediated responses are not dissimilar to those in plasma following anti-convulsant doses and are consistent with AMPA receptor antagonism being its primary mode of action...
  33. pmc Identification of new epilepsy treatments: issues in preclinical methodology
    Aristea S Galanopoulou
    Laboratory of Developmental Epilepsy, Saul R Korey Department of Neurology, Dominick P Purpura Department of Neuroscience, Montefiore Einstein Epilepsy Management Center, Albert Einstein College of Medicine, Bronx, NY, USA
    Epilepsia 53:571-82. 2012
  34. ncbi Comparison of phenobarbital with bromide as a first-choice antiepileptic drug for treatment of epilepsy in dogs
    Dawn Merton Boothe
    Department of Anatomy, Physiology and Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, AL 36849, USA
    J Am Vet Med Assoc 240:1073-83. 2012
    ..To compare efficacy and safety of treatment with phenobarbital or bromide as the first-choice antiepileptic drug (AED) in dogs...
  35. ncbi Levetiracetam has an activity-dependent effect on inhibitory transmission
    Anna L Meehan
    Department of Neurology, University of Minnesota, Minneapolis, MN, USA
    Epilepsia 53:469-76. 2012
    ..Because there are differences in excitatory and inhibitory transmitter release mechanisms, and there are suggestions that neurons differ in their SV2A expression, we were curious whether LEV also reduces inhibitory transmission...
  36. ncbi Effects of long-term antiepileptic drug monotherapy on vascular risk factors and atherosclerosis
    Yao Chung Chuang
    Department of Neurology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan
    Epilepsia 53:120-8. 2012
    ..We compared the long-term effects of monotherapy using different categories of AEDs on markers of vascular risk and the atherosclerotic process...
  37. ncbi Evaluation of adjunctive perampanel in patients with refractory partial-onset seizures: results of randomized global phase III study 305
    Jacqueline A French
    NYU Comprehensive Epilepsy Center, New York, New York 10016, USA
    Epilepsia 54:117-25. 2013
    ..To assess the efficacy and safety of once-daily doses of perampanel 8 and 12 mg when added to 1-3 concomitantly administered, approved antiepileptic drugs (AEDs) in patients with uncontrolled partial-onset seizures...
  38. pmc Adjunctive perampanel for refractory partial-onset seizures: randomized phase III study 304
    Jacqueline A French
    NYU Comprehensive Epilepsy Center, New York, NY, USA
    Neurology 79:589-96. 2012
  39. ncbi Timed pentylenetetrazol infusion test: a comparative analysis with s.c.PTZ and MES models of anticonvulsant screening in mice
    Sanjay N Mandhane
    Sun Pharma Advanced Research Centre, Tandalja, Vadodara 390 020, India
    Seizure 16:636-44. 2007
    ..v.PTZ test as an acute seizure model for screening of antiepileptic drugs. This model can identify molecules with varied mechanism of action and broad clinical utility in the treatment of epilepsy...
  40. ncbi Valproic acid, a mood stabilizer and anticonvulsant, protects rat cerebral cortical neurons from spontaneous cell death: a role of histone deacetylase inhibition
    Mi Ra Jeong
    Molecular Neurobiology Section, National Institute of Mental Health, National Institutes of Health, Bldg 10, Rm 4C 206, 10 Center Dr MSC 1363, Bethesda, MD 20892 1363, USA
    FEBS Lett 542:74-8. 2003
    ..Our results suggest a role of histone deacetylase inhibition in mediating the neuroprotective action of VPA...
  41. ncbi Efficacy and tolerability of the new antiepileptic drugs: comparison of two recent guidelines
    Ettore Beghi
    Epilepsy Center, University of Milano Bicocca, Ospedale San Gerardo, Monza, Italy
    Lancet Neurol 3:618-21. 2004
    ..In addition, 20-30% of patients are refractory to these drugs...
  42. ncbi Zebrafish offer the potential for a primary screen to identify a wide variety of potential anticonvulsants
    Stephane Berghmans
    DanioLabs Ltd, 7330 Cambridge Research Park, Cambridge CB25 9TN, UK
    Epilepsy Res 75:18-28. 2007
    The search for novel anticonvulsants requires appropriate model systems in which to test hypotheses through focused compound screening or genetic manipulation, or conduct black box screening of large numbers of compounds or potential ..
  43. ncbi Dose-dependent risk of malformations with antiepileptic drugs: an analysis of data from the EURAP epilepsy and pregnancy registry
    Torbjorn Tomson
    Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden
    Lancet Neurol 10:609-17. 2011
    ..We aimed to establish the risks of major congenital malformations after monotherapy exposure to four major antiepileptic drugs at different doses...
  44. ncbi Valproic acid phase shifts the rhythmic expression of Period2::Luciferase
    Anne Sofie Johansson
    Swedish Medical Nanoscience Center, Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    J Biol Rhythms 26:541-51. 2011
    ..These different molecular effects may underlie differential chronotherapeutic effects of VPA and lithium...
  45. pmc Antiepileptic drugs and apoptotic neurodegeneration in the developing brain
    Petra Bittigau
    Department of Pediatric Neurology, Children s Hospital, Charite Virchow Clinics, Humboldt University, Augustenburger Platz 1, 13353 Berlin, Germany
    Proc Natl Acad Sci U S A 99:15089-94. 2002
    ..Our findings present one possible mechanism to explain cognitive impairment and reduced brain mass associated with prenatal or postnatal exposure of humans to antiepileptic therapy...
  46. ncbi Antiepileptic treatment before the onset of seizures reduces epilepsy severity and risk of mental retardation in infants with tuberous sclerosis complex
    Sergiusz Jozwiak
    Department of Neurology and Epileptology, The Children s Memorial Health Institute, Warsaw, Poland
    Eur J Paediatr Neurol 15:424-31. 2011
    ..Clinical epileptic seizures are preceded by deterioration of EEG recording thus infants with high risk of epilepsy can be identified...
  47. ncbi Age and comedications influence levetiracetam pharmacokinetics in children
    Maria G Dahlin
    Department of Neuropediatrics, Astrid Lindgren Children s Hospital, Karolinska University Hospital, Stockholm, Sweden
    Pediatr Neurol 43:231-5. 2010
    ..In conclusion, younger age and comedication with an enzyme inducer increased levetiracetam clearance. This finding should be taken into account when treating individual patients...
  48. ncbi Self-reported medication adherence and treatment satisfaction in patients with epilepsy
    Waleed M Sweileh
    Department of Pharmacology and Toxicology, College of Pharmacy, An Najah National University, Nablus, Palestine
    Epilepsy Behav 21:301-5. 2011
    ..The objective of this study was to assess medication adherence and its relationship with treatment satisfaction, number of antiepileptic drugs (AEDs) taken, and epilepsy control in a sample of Palestinian patients...
  49. ncbi Homology modelling of the GABA transporter and analysis of tiagabine binding
    Søren Skovstrup
    Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark
    ChemMedChem 5:986-1000. 2010
    ..Hence, in presence of tiagabine, GAT-1 is constrained in an open-to-out conformation. Our results may be of particular interest for the design of new GAT-1 inhibitors...
  50. pmc The treatment of epilepsy in developing countries: where do we go from here?
    R A Scott
    Institute of Neurology, University College London, England
    Bull World Health Organ 79:344-51. 2001
    ..Much remains to be done but it is hoped that current efforts will lead to better treatment of people with epilepsy in developing countries...
  51. ncbi Sodium valproate: an old drug with new roles
    Natalia N Nalivaeva
    Institute of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, UK
    Trends Pharmacol Sci 30:509-14. 2009
    ..This article reviews the pharmacology of this remarkable molecule, focusing on its actions as a neuroprotectant and hence with new potential in the treatment of neurodegenerative diseases...
  52. ncbi Adverse effects of antiepileptic drugs: a brief overview of important issues
    Joyce A Cramer
    Yale University School of Medicine, New Haven, CT, USA
    Expert Rev Neurother 10:885-91. 2010
    ..This article describes three categories of prevalent adverse effects (CNS, behavioral and general medical issues) comparing profiles of second- and third-generation AEDs...
  53. ncbi The antinociceptive effects of anticonvulsants in a mouse visceral pain model
    Radica M Stepanovic-Petrovic
    Department of Pharmacology, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia
    Anesth Analg 106:1897-903. 2008
    ..In addition, the influence of these anticonvulsants on motor performance was examined to compare the tolerability of these anticonvulsants when used against ..
  54. pmc A diagnostic and therapeutic scheme for a solitary cysticercus granuloma
    G Singh
    Department of Neurology, Dayanand Medical College, Ludhiana, Punjab, India
    Neurology 75:2236-45. 2010
    ..Solitary cysticercus granuloma (SCG) is one of the most common forms of presentation of neurocysticercosis (NCC). The diagnostic workup and management approach to this condition remain uncertain and controversial...
  55. ncbi Non-alcoholic fatty liver disease (NAFLD), insulin resistance and lipid profile in antiepileptic drug treatment
    G Luef
    Department of Neurology, Epilepsy Unit, Medical University Innsbruck, Innsbruck, Austria
    Epilepsy Res 86:42-7. 2009
  56. pmc The ketogenic diet in a pill: is this possible?
    Jong M Rho
    Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, Arizona 85018, USA
    Epilepsia 49:127-33. 2008
  57. ncbi Is spontaneous high-voltage rhythmic spike discharge in Long Evans rats an absence-like seizure activity?
    Fu Zen Shaw
    Institute of Neuroscience, Tzu Chi University, Hualien 970, Taiwan
    J Neurophysiol 91:63-77. 2004
    ..These results were also collaborated using other genetic absence-seizure rats, such as WAG/Rij and GAERS rats. Possible mechanisms for the generation and termination of paroxysmal HVRS discharges are also discussed...
  58. ncbi Adherence to treatment in patients with epilepsy: associations with seizure control and illness beliefs
    R M Jones
    Mental Health Group, Community Clinical Sciences Division, University of Southampton, Royal South Hants Hospital, Brintons Terrace, Southampton SO14 OYG, United Kingdom
    Seizure 15:504-8. 2006
    ..The associations between adherence and seizure control, perceptions of illness and medication, anxiety and depression were also examined...
  59. ncbi Optimizing parameters for terminating cortical afterdischarges with pulse stimulation
    Gholam K Motamedi
    Department of Neurology, The Johns Hopkins University, Baltimore, Maryland, U S A
    Epilepsia 43:836-46. 2002
    ..We previously reported that brief pulses of electrical stimulation (BPSs) can terminate afterdischarges (ADs) during cortical stimulation. We investigated conditions under which BPS is more likely to suppress ADs...
  60. ncbi Polymorphism of the MDR1/ABCB1 C3435T drug-transporter and resistance to anticonvulsant drugs: a meta-analysis
    Facundo Garcia Bournissen
    Divisions of Clinical Pharmacology and Toxicology, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    Epilepsia 50:898-903. 2009
    ..the multidrug efflux ABCB1 (MDR1) drug-transporter; specifically, that patients with the 3435CC genotype have higher efflux of anticonvulsants out of brain tissue, with correspondingly lower concentrations in the central nervous system.
  61. pmc Magnesium sulfate for the treatment of eclampsia: a brief review
    Anna G Euser
    Department of Neurology, University of Vermont, Burlington, VT 05405, USA
    Stroke 40:1169-75. 2009
    ..This review summarizes current evidence supporting the possible mechanisms of action and several controversies for magnesium sulfate treatment...
  62. pmc Differences in cortical versus subcortical GABAergic signaling: a candidate mechanism of electroclinical uncoupling of neonatal seizures
    Joseph Glykys
    Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02144, USA
    Neuron 63:657-72. 2009
    ..Regional differences in the ontogeny of Cl(-) transport may thus explain why seizure activity in the cortex is not suppressed by anticonvulsants that block the transmission of seizure activity through subcortical networks.
  63. ncbi Transporters in drug-refractory epilepsy: clinical significance
    N Marchi
    Department of Cell Biology, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Clin Pharmacol Ther 87:13-5. 2010
    ..As discussed here, the field is replete with controversies and false starts, in particular as it concerns the existence of genetic predisposition to inadequate pharmacological seizure control...
  64. ncbi Treatment of refractory status epilepticus with pentobarbital, propofol, or midazolam: a systematic review
    Jan Claassen
    Department of Neurology, Division of Critical Care Neurology, and The Comprehensive Epilepsy Center, Neurological Institute, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Epilepsia 43:146-53. 2002
    ..This systematic review compares the efficacy of midazolam (MDL), propofol (PRO), and pentobarbital (PTB) for terminating seizures and improving outcome in RSE patients...
  65. ncbi Epilepsy in the United Kingdom: seizure frequency and severity, anti-epileptic drug utilization and impact on life in 1652 people with epilepsy
    N F Moran
    Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Seizure 13:425-33. 2004
    ..Secondly, to determine if these characteristics differ according to age...
  66. ncbi Pharmacology and mechanism of action of pregabalin: the calcium channel alpha2-delta (alpha2-delta) subunit as a target for antiepileptic drug discovery
    Charles P Taylor
    Department of CNS Biology, Pfizer Global Research and Development, 2800 Plymouth Road, Ann Arbor, MI 48105, USA
    Epilepsy Res 73:137-50. 2007
    ..This review addresses the preclinical pharmacology of pregabalin, and also the biology of the high affinity binding site, and presumed site of action...
  67. ncbi Drug resistance in epilepsy: expression of drug resistance proteins in common causes of refractory epilepsy
    S M Sisodiya
    Epilepsy Research Group, University Department of Clinical Neurology, University College London, London, UK
    Brain 125:22-31. 2002
    ..We propose that overexpressed resistance proteins lower the interstitial concentration of AEDs in the vicinity of the epileptogenic pathology and thereby render the epilepsy caused by these pathologies resistant to treatment with AEDs...
  68. ncbi The treatment gap in epilepsy: the current situation and ways forward
    H Meinardi
    Department of Physiology, Leyden University Medical Centre, P O Box 9604, 2300 RC Leiden, The Netherlands
    Epilepsia 42:136-49. 2001
    ..It is hoped that these may be transferable elsewhere and that, combined with the ILAE/IBE/WHO Global Campaign against Epilepsy and increased support from the worldwide epilepsy community, the treatment gap will begin to be bridged...
  69. pmc Mammalian target of rapamycin (mTOR) inhibition as a potential antiepileptogenic therapy: From tuberous sclerosis to common acquired epilepsies
    Michael Wong
    Department of Neurology and the Hope Center for Neurological Disorders, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Epilepsia 51:27-36. 2010
    ..Therefore, mTOR inhibition may represent a potential antiepileptogenic therapy for diverse types of epilepsy, including both genetic and acquired epilepsies...
  70. pmc Identification of pharmacoresistant epilepsy
    Anne T Berg
    Department of Biology, Northern Illinois University, DeKalb, IL 60115, USA
    Neurol Clin 27:1003-13. 2009
    ..Maximizing seizure control is imperative for reducing the risks and consequences of epilepsy, including the cognitive and psychiatric comorbidities and even sudden death...
  71. pmc Neonatal exposure to antiepileptic drugs disrupts striatal synaptic development
    Patrick A Forcelli
    Interdisciplinary Program in Neuroscience, Georgetown University, School of Medicine, Washington, DC, USA
    Ann Neurol 72:363-72. 2012
    ..The functional significance of the preclinical neurotoxicity has been questioned due to the absence of evidence for functional impairment associated with drug-induced developmental apoptosis...
  72. ncbi Long-term valproate and lamotrigine treatment may be a marker for reduced growth and bone mass in children with epilepsy
    C Y Guo
    Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada
    Epilepsia 42:1141-7. 2001
    ..These alterations may be mediated primarily through reduced physical activity rather than through a direct link to the VPA and/or LTG therapy...
  73. pmc The antiepileptic drug valproic acid and other medium-chain fatty acids acutely reduce phosphoinositide levels independently of inositol in Dictyostelium
    Pishan Chang
    Centre for Biomedical Sciences, School of Biological Sciences, Royal Holloway University of London, Egham, TW20 0EX, UK
    Dis Model Mech 5:115-24. 2012
    ..Together, our data show that VPA and a newly identified group of medium-chain fatty acids reduce phosphoinositide levels independently of inositol regulation, and suggest the reinvestigation of these compounds as treatments for epilepsy...
  74. ncbi Two-year remission and subsequent relapse in children with newly diagnosed epilepsy
    A T Berg
    Department of Biological Sciences, Northern Illinois University, DeKalb, Illinois 60115, USA
    Epilepsia 42:1553-62. 2001
    ..The purpose of this study was to examine remission and relapse with respect to the epilepsy syndrome and other factors traditionally considered with respect to seizure outcome...
  75. ncbi Effect of sildenafil on the anticonvulsant action of classical and second-generation antiepileptic drugs in maximal electroshock-induced seizures in mice
    Dorota Nieoczym
    Department of Animal Physiology, Institute of Biology, Maria Curie Skłodowska University, Lublin, Poland
    Epilepsia 51:1552-9. 2010
  76. ncbi Antiepileptic drugs and brain development
    Chrysanthy Ikonomidou
    Department of Neurology and Waisman Center, University of Wisconsin, Madison, USA
    Epilepsy Res 88:11-22. 2010
  77. ncbi A nonsynonymous variation in MRP2/ABCC2 is associated with neurological adverse drug reactions of carbamazepine in patients with epilepsy
    Won Joo Kim
    Departments of Pharmacology, Brain Korea 21 Project for Medical Sciences, Yonsei University College of Medicine, 134 Sinchon dong, Seoul, Korea
    Pharmacogenet Genomics 20:249-56. 2010
    ..Therefore, genetic variations in the MRP2 gene may affect individual drug responses to the antiepileptic agent carbamazepine...
  78. ncbi Cognition and behavior in children with benign epilepsy with centrotemporal spikes (BECTS)
    B Giordani
    Department of Psychiatry Neuropsychology, Department of Neurology, 1500 East Medical Center Drive, Ann Arbor, MI 48109 0840, USA
    Epilepsy Res 70:89-94. 2006
    ..Parental concerns for psychosomatic and learning problems were noted. Monitoring select cognitive and behavioral features in BECTS appears appropriate...
  79. ncbi Prevalence of active epilepsy and health-related quality of life among adults with self-reported epilepsy in California: California Health Interview Survey, 2003
    Rosemarie Kobau
    Centers for Disease Control and Prevention, Division of Adult and Community Health, Epilepsy Program, Atlanta, Georgia 30341, USA
    Epilepsia 48:1904-13. 2007
  80. ncbi Association between anticonvulsant hypersensitivity syndrome and human herpesvirus 6 reactivation and hypogammaglobulinemia
    Yoko Kano
    Department of Dermatology, Kyorin University School of Medicine, Tokyo, Japan
    Arch Dermatol 140:183-8. 2004
    ..The identification of predisposing factors is clearly needed to predict the incidence and outcome of AHS; attention has recently been focused on reactivation of human herpesvirus 6 (HHV-6)...
  81. ncbi Idiosyncratic adverse reactions to antiepileptic drugs
    Gaetano Zaccara
    Neurology Unit, ASL 10, Firenze, Italy
    Epilepsia 48:1223-44. 2007
    ..Serious consequences of idiosyncratic reactions can be minimized by knowledge of risk factors, avoidance of specific AEDs in subpopulations at risk, cautious dose titration, and careful monitoring of clinical response...
  82. ncbi History of epilepsy in Medieval Iranian medicine
    A Gorji
    Institut fur Physiologie, Universitat Munster, Robert Koch Strasse 27a, 48149 Munster, Germany
    Neurosci Biobehav Rev 25:455-61. 2001
    ..Their findings about epilepsy are very accurate and vivid and many of them are accepted even today...
  83. ncbi A randomized trial of classical and medium-chain triglyceride ketogenic diets in the treatment of childhood epilepsy
    Elizabeth G Neal
    UCL Institute of Child Health and Great Ormond Street Hospital for Children NHS Trust, London, United Kingdom
    Epilepsia 50:1109-17. 2009
    ..To conduct the first randomized trial on classical and medium-chain triglyceride (MCT) versions of the ketogenic diet, examining efficacy and tolerability after 3, 6, and 12 months...
  84. ncbi Antidepressants for the acute treatment of bipolar depression: a systematic review and meta-analysis
    Michelle M Sidor
    Department of Psychiatry, University of Texas, Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9070, USA
    J Clin Psychiatry 72:156-67. 2011
    ..The current systematic review and meta-analyses reexamine the efficacy and safety of antidepressant use for the acute treatment of bipolar depression...
  85. ncbi Neuropsychological disorders related to interictal epileptic discharges during sleep in benign epilepsy of childhood with centrotemporal or Rolandic spikes
    M G Baglietto
    Unità Operativa di Neuropsichiatria Infantile, Istituto G Gaslini Largo G Genova, Italy
    Dev Med Child Neurol 43:407-12. 2001
    ..At T1, patients' performance did not differ from the controls (Mann-Whitney U test)...
  86. ncbi Topiramate reduces AMPA-induced Ca(2+) transients and inhibits GluR1 subunit phosphorylation in astrocytes from primary cultures
    Mikael Angehagen
    Institute of Clinical Neuroscience, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    J Neurochem 94:1124-30. 2005
    ..Furthermore, it was shown that TPM binds to AMPA receptors in the dephosphorylated state and thereby exerts an allosteric modulatory effect on the ion channel...
  87. ncbi Valproate and neuroendocrine changes in relation to women treated for epilepsy and bipolar disorder: a review
    M F Reynolds
    Yale University School of Medicine, New Haven, CT 06510, USA
    Curr Med Chem 14:2799-812. 2007
    ..This article reviews the current understanding of VPA's mechanisms of action, effects on the reproductive and metabolic system, and teratogenic qualities, highlighting important future areas of study...
  88. ncbi Trace elements and electrolytes homeostasis and their relation to antioxidant enzyme activity in brain hyperexcitability of epileptic patients
    Sherifa A Hamed
    Department of Neurology, Assiut University Hospital
    J Pharmacol Sci 96:349-59. 2004
    ..Trace elements and antioxidant might have neuroprotective biological targeted benefits when used in epileptic patients...
  89. ncbi Topiramate as add-on treatment for patients with bipolar mania
    K N Chengappa
    Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, PA 15215 2593, USA
    Bipolar Disord 1:42-53. 1999
    ..Topiramate (Topamax), a new antiepileptic agent, is a candidate drug for bipolar disorder. We evaluated topiramate as adjunctive treatment for bipolar patients...
  90. pmc Early alterations of AMPA receptors mediate synaptic potentiation induced by neonatal seizures
    Sanjay N Rakhade
    Department of Neurology, Division of Neuroscience, Children s Hospital, Boston, Massachusetts 02115, USA
    J Neurosci 28:7979-90. 2008
    ..Thus, the potentiation of AMPAR-containing synapses is a reversible, early step in epileptogenesis that offers a novel therapeutic target in the highly seizure-prone developing brain...
  91. pmc Neuropathic pain: a practical guide for the clinician
    Ian Gilron
    Department of Anesthesiology, Queen s University and Kingston General Hospital, Kingston, Ont
    CMAJ 175:265-75. 2006
    ..In coming years, several advances are expected in the basic and clinical sciences of neuropathic pain, which will provide new and improved therapies for patients who continue to experience this disabling condition...
  92. ncbi Long-term seizure outcome of surgery versus no surgery for drug-resistant partial epilepsy: a review of controlled studies
    Dieter Schmidt
    Epilepsy Research Group Berlin, Germany
    Epilepsia 50:1301-9. 2009
  93. ncbi Prolonged valproic acid treatment does not reduce the size of latent HIV reservoir
    Nathalie Sagot-Lerolle
    INSERM, U802, Bicetre, France
    AIDS 22:1125-9. 2008
    ..To investigate the impact of prolonged valproic acid treatment on the HIV reservoir in patients on highly active antiretroviral therapy...
  94. ncbi Abnormal fear conditioning and amygdala processing in an animal model of autism
    Kamila Markram
    Brain Mind Institute, Swiss Federal Institute of Technology EPFL, Lausanne, Switzerland
    Neuropsychopharmacology 33:901-12. 2008
    ..We hypothesize an 'aversive world' syndrome that could, even if not a primary cause of the disorder itself, underlie some core symptoms in autism, such as impairments in social interactions and resistance to rehabilitation...
  95. ncbi Limbic seizures induce P-glycoprotein in rodent brain: functional implications for pharmacoresistance
    Massimo Rizzi
    Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri, 20157 Milano, Italy
    J Neurosci 22:5833-9. 2002
    ..P-gp alterations significantly affect antiepileptic drugs concentrations in the brain, suggesting that seizure-induced mdr mRNA expression contributes to MDR in epilepsy...
  96. ncbi The impact of pregnancy and childbirth on the metabolism of lamotrigine
    P B Pennell
    Departments of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Neurology 62:292-5. 2004
    ..LTG clearance progressively increased until 32 weeks' gestational age, reaching a peak of >330% of baseline, and then began to decline...
  97. ncbi Current status and future directions in the pharmacotherapy of epilepsy
    Wolfgang Loscher
    Dept of Pharmacology, Toxicology and Pharmacy, School of Veterinary Medicine, Buenteweg 17, D 30551 Hannover, Germany
    Trends Pharmacol Sci 23:113-8. 2002
    ..In this article, I assess the current status of antiepileptic therapies and highlight innovative approaches for future treatments...
  98. ncbi Refractory epilepsy: clinical overview
    Jacqueline A French
    Department of Neurology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Epilepsia 48:3-7. 2007
  99. ncbi Anticonvulsant medications extend worm life-span
    Kimberley Evason
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO 63110, USA
    Science 307:258-62. 2005
    ..These compounds, two of which are approved for human use, are anticonvulsants that modulate neural activity. These compounds also regulated neuromuscular activity in nematodes...
  100. ncbi Prevalence and cost of nonadherence with antiepileptic drugs in an adult managed care population
    Keith L Davis
    Health Economics, RTI Health Solutions, Research Triangle Park, North Carolina 27709, USA
    Epilepsia 49:446-54. 2008
    ..This study assessed the extent of refill nonadherence with antiepileptic drugs (AEDs) and the potential association between AED nonadherence and health care costs in an adult-managed care population...
  101. ncbi Common risk allele in aromatic antiepileptic-drug induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Han Chinese
    Shuen Iu Hung
    Institute of Biomedical Sciences, Academia Sinica, 128, Academia Road, Section 2, Nankang, Taipei 11529, Taiwan
    Pharmacogenomics 11:349-56. 2010
    ..Here, we extend the study of HLA susceptibility to three different antiepileptic drugs, phenytoin (PHT), lamotrigine (LTG) and oxcarbazepine (OXC), which have structure similarity to CBZ...

Research Grants72

  1. Design and Synthesis of Anxioselective Anxiolytics
    James M Cook; Fiscal Year: 2010
    ..Despite the clinical effectiveness of these drugs, there is a need for selective anxiolytics and anticonvulsants which are devoid of the sedative-hypnotic, muscle-relaxant, ataxic and amnestic effects...
  2. Acu/Moxa for Peripheral Neuropathy in Pts with HIV
    JOYCE ANASTASI; Fiscal Year: 2007 manage the pain associated with DSP, such as nonnarcotic and narcotic analgesics, antidepressants and anticonvulsants, are largely ineffective...
  3. The Medial Entorhinal Cortex and Temporal Lobe Epilepsy
    KAREN WILCOX; Fiscal Year: 2007
    ..These experiments will set the stage for the development of future therapeutic interventions for the treatment of pharmacoresistant epilepsy. [unreadable] [unreadable]..
  4. Attenuating the retinal and CNS adverse effects of vigabatrin with NKCC1 inhibito
    Frances E Jensen; Fiscal Year: 2010
    ..of patients with epilepsy suffer refractory seizures, and do not reach seizure suppression with conventional anticonvulsants. Infantile spasms is a subgroup of epilepsy and has an incidence of approximately 1 per 2000 live births, ..
  5. Optimization of KCa2 Channel Activators as Neuroscience Tools and Potential Drugs
    Heike Wulff; Fiscal Year: 2012
    ..the NIH Anticonvulsant Screening Program (ASP) that the compound and several of its derivatives are effective anticonvulsants. Unfortunately, SKA-31 also activates KCa3...
  6. TBI epileptogenesis: pathologic hippocampal L-glut synaptic plasticity
    John T Slevin; Fiscal Year: 2011
  7. In vivo mechanisms of methamphetamine-induced neuronal necrosis
    Denson G Fujikawa; Fiscal Year: 2013
    ..Our finding that METH-induced subclinical RESDs in mice are associated with widespread neuronal damage could have important translational applicability. ..
  8. Heat Waves, Medication Use, and Adverse Health Outcomes Among Older Adults
    SOKO SETOGUCHI-IWATA; Fiscal Year: 2013
  9. Calcium Signaling in a Model of Temporal Lobe Epilepsy
    Karen S Wilcox; Fiscal Year: 2013
    ..Finally it is anticipated that the proposed experiments will lead to the identification of novel molecular targets for innovative therapeutic approaches for the treatment, prevention, and/or cure of this devastating seizure disorder. ..
  10. Physiological mechanisms responsible for cognitive impairments in Dravet Syndrome
    Pierre Pascal Lenck-Santini; Fiscal Year: 2013
    ..It would suggest that additional treatment strategies focusing on cognitive function, other than traditional antiepileptic drugs may be necessary to recover normal cognitive function in affected children. ..
  11. Neuroactive Steroids and Seizure Control during Pregnancy in Women with Epilepsy
    PAGE BUCKHANNAN PENNELL; Fiscal Year: 2010
    ..These findings could lead to the development of novel treatment strategies for women with epilepsy during pregnancy, such as use of supplemental progesterone, to improve mother and child health outcomes. ..
  12. Identifying neurons and circuits critical for epileptogenesis
    Istvan Mody; Fiscal Year: 2013
    ..The new discoveries will facilitate the translation of our basic findings into clinical practice. ..
  13. Therapeutic effects of ketogenic diet in a mouse model of severe myoclinic epilep
    Franck K Kalume; Fiscal Year: 2013
    ..Furthermore, this study will give new insights that may help in the design of future pharmacological- or non-pharmacological therapies for SMEI and other epilepsy syndrome refractory to current antiepileptic drugs. ..
  14. Neurosteroid-BZ combinations: Strategy for reducing abuse and sedation
    James K Rowlett; Fiscal Year: 2013 applicant): Benzodiazepines (BZs) are prescribed widely as anxiolytics, hypnotics, muscle relaxants, and anticonvulsants. Although BZs are among the safest psychoactive drugs in modern medicine, their utility is often limited by ..
  15. Process for Removal of Microcontaminants from Municipal Water
    JAMES H WHITE; Fiscal Year: 2010
    ..Concern exists over the long-term health effects that will result from ingesting antibiotics, anticonvulsants, mood stabilizers, sex hormones and other drugs...
  16. Structure of the GABA-A Receptor Binding Sites
    CYNTHIA M CZAJKOWSKI; Fiscal Year: 2012
    ..and psychiatric disorders and a number of therapeutic drugs, including muscle relaxants, sedative-hypnotics, anticonvulsants, anxiolytics, intravenous and volatile anesthetics, anti-emetics, drugs for nicotine addiction and drugs to ..
  17. Efficacy of GluR5 Antogonists Against Soman-Induced Seizures and Neuropathology
    MARIA F BRAGA; Fiscal Year: 2013
    ..Including a section of the particularly vulnerable population, and will result in the development of new compounds that will reduce mortality and morbidity during and after an emergency event involving nerve agents. ..
    Jianxin Bao; Fiscal Year: 2010
    ..In the R21 phase of this application, we will develop a combination therapy with anticonvulsants and synthetic glucocorticoids in one mouse NIHL condition, which has dramatic changes for both temporary and ..
  19. Novel Thioderivatives as Neuroprotective Anticonvulsants
    DOUGLAS ERIC BRENNEMAN; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Novel Thioderivatives as Neuroprotective Anticonvulsants Abstract: The aim is to discover novel lead compounds that provide a disease- modifying therapeutic for the treatment of epilepsy...
  20. Functional Imaging of Tremor Circuits and Mechanisms of Treatment Response.
    Fatta B Nahab; Fiscal Year: 2013
    ..Treatment of ET focuses on pharmacological agents of various mechanisms (e.g. b-blockers, anticonvulsants, benzodiazepines) and rarely deep brain stimulation of the Vim thalamus...
  21. Developing GalR 1/2 Agonists to Treat Nerve Gas Induced Seizure
    Tamas Bartfai; Fiscal Year: 2010
    ..In this proposal, we aim at the development of potent novel anticonvulsants for the treatment of OP-NG induced seizures...
  22. The NKCC1 inhibitor bumetanide as a novel therapy in TSC
    Frances E Jensen; Fiscal Year: 2013 support an early Phase I/II trial of bumetanide as an add-on therapy with conventional GABA agonist anticonvulsants like phenobarbital or other newer agents like vigabatrin for seizure control in TSC patients...
  23. Development of predictive in vitro model of drug absorption across the human BBB
    Damir Janigro; Fiscal Year: 2010
    ..If our hypothesis is correct we may acquire new tools to treat epilepsy in children and adults. ..
  24. Metabolic Mechanisms of Functional Neuroprotection in Epileptic Brain
    Do Young Kim; Fiscal Year: 2013
    ..This proposal will explore a potential molecular mechanism through which ketone bodies might exert such effects. ..
  25. A Neurosteroid-based Novel Treatment for OP-Intoxication
    Doodipala Samba Reddy; Fiscal Year: 2012
    ..Neurosteroids are the most powerful anticonvulsants against seizures induced by cholinergic agents...
  26. Neurosteroid Treatment for OP Intoxication
    Doodipala Samba Reddy; Fiscal Year: 2013
    ..Neurosteroids are the most powerful anticonvulsants against seizures induced by cholinergic agents...
    Jianxin Bao; Fiscal Year: 2013
    ..In the R21 phase of this application, we will develop a combination therapy with anticonvulsants and synthetic glucocorticoids in one mouse NIHL condition, which has dramatic changes for both temporary and ..
  28. Treatment of Status Epilepticus: A Translational Proposal
    Claude G Wasterlain; Fiscal Year: 2013
    ..use or are close to approval, and were able to stop severe experimental SE with low subanesthetic doses of anticonvulsants. Therapeutic success with this receptor-based approach to drug selection would confirm the importance of ..
  29. Mechanisms by which T-type calcium channels increase seizure susceptibility
    Edward Perez Reyes; Fiscal Year: 2010
    ..The studies will likely have a clinical impact: showing that T-channel antagonists reverse the effects of Cav3.2 variants on dendritic development, thereby providing the rationale for their early use to cure epilepsy. ..
  30. Molecular Physiology of y-Aminobutyric Acid Transporters
    Sepehr Eskandari; Fiscal Year: 2012
    ..The proposed research examines the mechanism of function of GABA transporters and will pave the way for the development of novel isoform-specific antiepileptic drugs. ..
  31. Structural biology of neurotransmitter ion channels
    James E Gouaux; Fiscal Year: 2013
    ..important, these ion channels are the targets of many therapeutic agents, from sedatives and anesthetics to anticonvulsants, and they are implicated or associated with a broad range of devastating diseases including Alzheimer's ..
  32. Neural Grafts and Injury-Induced Hippocampal Dysfunction
    Ashok K Shetty; Fiscal Year: 2010
    ..Collectively, the proposed experiments have immense value for the development of apt treatment strategy that prevents both chronic epilepsy and learning and memory impairments after hippocampal injury in adults. ..
  33. Epilepsy and dendritic excitability
    Nicholas P Poolos; Fiscal Year: 2013
    ..The outcome of this study may identify specific biochemical pathways that could be targeted for development of novel antiepileptic drugs, improving the likelihood that currently poorly-controlled patients may one day be seizure-free. ..
  34. Bone and Hormonal Health in Premenopausal Women with Epilepsy
    Alison M Pack; Fiscal Year: 2010
    ..By defining and understanding the risk that epilepsy and antiepileptic drugs have on bone health, we will significantly impact those persons with epilepsy treated with antiepileptic drugs. ..
  35. Citalopram Treatment for Agitation in Alzheimer Dementia
    Constantine G Lyketsos; Fiscal Year: 2012
    ..Several pharmacologic options have been explored, but findings for anticonvulsants, antipsychotics, and cholinesterase inhibitors are disappointing or associated with questionable risk: ..
  36. The Effects of Antiepileptic Drugs on Serologic Indices of Vascular Risk
    Scott Mintzer; Fiscal Year: 2012
  37. Perisomatic Inhibitory Network Dysfunction in Neurological Disease
    Vijayalakshmi Santhakumar; Fiscal Year: 2013
    ..It is anticipated that the study will identify fundamental mechanisms underlying dynamical instability of dentate network activity in acquired epilepsy. ..
  38. Development of a galanin-based therapy for the treatment of refractory epilepsy
    H Steve White; Fiscal Year: 2013
    ..The goal of this proposal is to apply our proprietary technology to develop a novel galanin-based therapy for treating this debilitating disorder. ..
  39. The role of brainstem in the generation of infantile spasms
    Aristea S Galanopoulou; Fiscal Year: 2010
    ..We anticipate that the outcome of this study will provide new insights into the pathophysiology of the disease opening new avenues for effective treatments. ..
  40. Anticonvulsant effects of novel concentric ring electrode electrical stimulation
    WALTER GRANT BESIO; Fiscal Year: 2010
    ..A non-invasive therapeutic strategy for bedside and/or out-of-hospital intervention can significantly improve morbidity and mortality, as well as reduce risk and cost of treatment. ..
  41. Insecticide Action at the Local Anesthetic Receptor
    David M Soderlund; Fiscal Year: 2011
    ..g., local anesthetics, antiarrhythmics, anticonvulsants, neuroprotectants and analgesics) that bind to the "local anesthetic receptor" site of sodium channels...
  42. A Dose-Escalation, Safety and Feasibility Study of Enteral Levetiracetam for Seizure Control in Pediatric Cerebral Malaria
    Gretchen Lano Birbeck; Fiscal Year: 2013
    ..Since enteral LVT is relatively affordable for short-term use and could be feasibly delivered in resource limited settings, this therapy could potentially be scaled up for broad use throughout malaria endemic African countries. ..
  43. GABA transporter type 1 (GAT1) function in epilepsy
    ..Identification of changes in nonvesicular release in GAT1 knockout neurons and determination of AED effects on nonvesicular release in Specific Aims 1-2 will provide a basis for interpretation of in vivo data. ..
  44. Short and long-term impact of neonatal seizures on hippocampal granule cell integ
    Steve C Danzer; Fiscal Year: 2010
    ..These studies will help to determine whether and how neonatal seizures harm young brains, and will guide the development of mitigating strategies and treatments. ..
  45. Glutamine Synthetase and the Mechanism of Seizures in Mesial Temporal Lobe Epilep
    Tore Eid; Fiscal Year: 2013
    ..The hypothesis is that restoration of glutamine synthetase in the hippocampus leads to cessation of seizures even in the presence of extensive brain pathology. ..
  46. Sodium channels and neuronal excitability in chronic limbic epilepsy.
    Manoj K Patel; Fiscal Year: 2013
    ..These findings support our central hypothesis that changes in Na channel expression and physiology contribute to the development of epilepsy. ..
  47. A US-Mexico Collaborative Effort to Improve Epilepsy Control and Diagnosis
    WALTER GRANT BESIO; Fiscal Year: 2013
    ..This grant will help build sustainable research capacity in Mexico in epilepsy and neurological disorders in general. ..
  48. Pilot Trial of Bumetanide for Neonatal Seizures
    JANET SUSAN SOUL; Fiscal Year: 2013
    ..Data from this pilot study will be used to guide design of a planned Phase III multicenter trial to test the efficacy of BTN to control refractory neonatal seizures. ..
    Wayne N Frankel; Fiscal Year: 2013
    ..e. without side-effects, potentially leading to more effective therapies in the future. They will also serve as candidates for genetically complex human epilepsy as well. ..
  50. Moderate-throughput screening for anti-epileptogenic drugs.
    Kevin J Staley; Fiscal Year: 2012
    ..In vivo testing will be used to confirm the effects of the most promising agents found in the first stage of screening. ..
  51. Neurophysiologically Based Responsive Pharmacotherapy for Epilepsy
    Gregory A Worrell; Fiscal Year: 2013
    ..Thus the Resume and Summary of Discussion is the final word on what the reviewers actually considered critical at the meeting. ..
  52. Analysis of the Role of SV2A Phosphorylation in Epilepsy
    Roger Janz; Fiscal Year: 2013
    ..This experiment will test the hypothesis that epilepsy in human tissue leads to changes in the phosphorylation of SV2A and if levetiracetam treatment affects these changes. ..
  53. Ischemic Injury and Neuroprotection in the Immature Brain
    Anne M Comi; Fiscal Year: 2010
    ..after ischemia, and to gain facility in carrying out rigorous mouse trials of neuroprotection with anticonvulsants. Stroke in the term neonate or infant is an important cause of neurologic morbidity. Dr...
  54. Astrocyte Dysfunction in Epilepsy
    Maiken Nedergaard; Fiscal Year: 2010
    ..By more specifically targeting the glial cause of neuronal excitability, we might be able to achieve more specific, less variable and less toxic treatment options for patients with epilepsy. ..
  55. Extended NeuroAmides: Novel Antiepileptic Drug Candidates
    Harold Kohn; Fiscal Year: 2012
    ..The proposed investigation provides a critical path for ENA development and selection allowing for IND- enabling studies in the STTR phase II study. ..
  56. Anticonvulsants, ischemic seizures and regeneration in the immature brain
    Anne M Comi; Fiscal Year: 2013
    ..Neonatal strokes present with seizures, and anticonvulsants (usually phenobarbital) are administered for months afterward...
  57. Supporting Treatment Adherence Regimens in Pediatric Epilepsy: The STAR Trial
    Avani C Modi; Fiscal Year: 2013
    ..In addition, this study's innovative methodological enrichment design should be generalizable to other pediatric conditions and lead to the development of cost effective, clinic-based adherence promotion interventions. ..
  58. Interdisciplinary Study of Two Novel Anticonvulants in Alcoholism
    DOMENIC ANTHONY CIRAULO; Fiscal Year: 2013
    ..This investigation will examine the effects of representative anticonvulsants from three chemical classes: a sugar sulfamate, topiramate;a heterocyclic sulfonamide, zonisamide;and a ..
  59. EEG-fMRI in Patients with JME
    Jerzy P Szaflarski; Fiscal Year: 2010
    ..Szaflarski is to develop skills necessary to become an independent clinical investigator in the area of neuroimaging in epilepsy, with independent research funding by the time the training is completed. ..
  60. Innate and Adaptive Immunity in Childhood Epilepsy
    Sookyong Koh; Fiscal Year: 2013
    ..The results should also determine the potential beneficial impact of anti-inflammatory drugs for early anti- epileptic therapy. ..
  61. Improving Patient Safety by Reducing Medication Errors
    BRIAN STROM; Fiscal Year: 2005
    ..The elderly are particularly at risk for such complications. The highest risk drugs include anticoagulants, anticonvulsants, antimicrobials, and digoxin...
  62. Maternal Outcomes and Neurodevelopmental Effects of Antiepileptic Drugs (MONEAD)
    PAGE BUCKHANNAN PENNELL; Fiscal Year: 2013
    ..In addition, genetic samples will be collected, which will provide a valuable resource for future pharmacogenetics studies to further delineate individual variability across patients. ..
  63. Adaptive control of epileptic seizures using a genetically encoded sensor
    Galit Pelled; Fiscal Year: 2013
    ..abstract_text> ..
    Steve White; Fiscal Year: 1991
    ..These studies are designed to test the hypothesis that anticonvulsants in addition to their effects on neurons and synapses also stimulate astrocytic regulatory processes, and in ..
    Manoj K Patel; Fiscal Year: 2010
    ..These drugs could be effective in patients that are "pharmaco-resistant" to currently available drugs. ..
    Steven Peterson; Fiscal Year: 1991 determine if localized substantia nigra infusions of glycine potentiate systemically administered anticonvulsants in the same 3 models of epilepsy...
    DIWAKAR DESHMUKH; Fiscal Year: 1993
    The mode of action of anesthetics and anticonvulsants is not yet clarified although the most useful of anticonvulsant drugs, phenobarbital, has been in use for 75 years...
    James Cook; Fiscal Year: 1992
    ..Bz) employed to treat anxiety are a group of compounds with wide therapeutic applications as anxiolytics, anticonvulsants, hypnotics and muscle relaxants 6,7...
  69. Pharmacoresistance in rats with kainate-induced epilepsy
    F Dudek; Fiscal Year: 2005
    ..abstract_text> ..
  70. Astrocytes and temporal lobe epilepsy
    KAREN WILCOX; Fiscal Year: 2009
    ..It is anticipated that this work will reveal new potential therapeutic targets for the treatment of epilepsy. ..
  71. Third International Workshop on Seizure Prediction - Freiburg, Germany, 2007
    Hitten Zaveri; Fiscal Year: 2007
    ..Investigators whose participation will be supported will be invited speakers and junior and senior investigators including women and racial and ethnic minorities. [unreadable] [unreadable] [unreadable]..
    PANKAJA KADABA; Fiscal Year: 1993
    ..The triazolines and the amino alkylpyridine metabolite analogues, a group of novel anticonvulsants appear to be effective in the kindling and in the maximal electroshock seizure models of epilepsy, the best ..