opioid analgesics


Summary: Narcotic or opioid substances, synthetic or semisynthetic agents producing profound analgesia, drowsiness, and changes in mood. Mood changes may be pleasurable, therefore creating a potential for the abuse of these agents; the prototype of these is morphine to which all other analgesics are compared.

Top Publications

  1. ncbi Opioid analgesics for pain control: wisconsin physicians' knowledge, beliefs, attitudes, and prescribing practices
    Marla Z Wolfert
    University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin WI 53792, USA
    Pain Med 11:425-34. 2010
  2. ncbi EULAR evidence-based recommendations for the management of fibromyalgia syndrome
    S F Carville
    Academic Rheumatology Unit, King s College London, Weston Education Centre, Cutcombe Road, London SE5 9RJ, UK
    Ann Rheum Dis 67:536-41. 2008
  3. ncbi Effects of the CYP2D6 gene duplication on the pharmacokinetics and pharmacodynamics of tramadol
    Julia Kirchheiner
    Institute of Clinical Pharmacology, Charite University Medicine, Berlin, Germany
    J Clin Psychopharmacol 28:78-83. 2008
  4. pmc Prescribing of opioid analgesics and related mortality before and after the introduction of long-acting oxycodone
    Irfan A Dhalla
    Department of Medicine, University of Toronto, and the Keenan Research Centre of the Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Ontario
    CMAJ 181:891-6. 2009
  5. ncbi Morphine prevents the mitochondrial permeability transition pore opening through NO/cGMP/PKG/Zn2+/GSK-3beta signal pathway in cardiomyocytes
    Jinkun Xi
    Department of Anesthesiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Am J Physiol Heart Circ Physiol 298:H601-7. 2010
  6. ncbi Opioid complications and side effects
    Ramsin Benyamin
    Millennium Pain Center, Bloomington, IL 61701, USA
    Pain Physician 11:S105-20. 2008
  7. ncbi State-dependent opioid control of pain
    Howard Fields
    University of California, 513 Parnassus Avenue, San Francisco, California 94143, USA
    Nat Rev Neurosci 5:565-75. 2004
  8. pmc Opioids for chronic noncancer pain: a meta-analysis of effectiveness and side effects
    Andrea D Furlan
    Comprehensive Pain Program, Toronto Western Hospital, Ont
    CMAJ 174:1589-94. 2006
  9. ncbi Increasing deaths from opioid analgesics in the United States
    Leonard J Paulozzi
    Division of Unintentional Injury Prevention, National Center for Injury Prevention and Control, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Pharmacoepidemiol Drug Saf 15:618-27. 2006
  10. pmc Use of opioid medications for chronic noncancer pain syndromes in primary care
    M Carrington Reid
    Clinical Epidemiology Unit, VA Connecticut Healthcare System, West Haven Conn 06516, USA
    J Gen Intern Med 17:173-9. 2002

Detail Information

Publications280 found, 100 shown here

  1. ncbi Opioid analgesics for pain control: wisconsin physicians' knowledge, beliefs, attitudes, and prescribing practices
    Marla Z Wolfert
    University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin WI 53792, USA
    Pain Med 11:425-34. 2010
    b>Opioid analgesics are the drugs of choice for the treatment of moderate to severe acute and cancer pain...
  2. ncbi EULAR evidence-based recommendations for the management of fibromyalgia syndrome
    S F Carville
    Academic Rheumatology Unit, King s College London, Weston Education Centre, Cutcombe Road, London SE5 9RJ, UK
    Ann Rheum Dis 67:536-41. 2008
    ..To develop evidence-based recommendations for the management of fibromyalgia syndrome...
  3. ncbi Effects of the CYP2D6 gene duplication on the pharmacokinetics and pharmacodynamics of tramadol
    Julia Kirchheiner
    Institute of Clinical Pharmacology, Charite University Medicine, Berlin, Germany
    J Clin Psychopharmacol 28:78-83. 2008
    ..Therefore, tramadol may frequently cause adverse effects in southern European and Northern African populations with a high proportion of UMs...
  4. pmc Prescribing of opioid analgesics and related mortality before and after the introduction of long-acting oxycodone
    Irfan A Dhalla
    Department of Medicine, University of Toronto, and the Keenan Research Centre of the Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Ontario
    CMAJ 181:891-6. 2009
    ..Opioid-related mortality appears to be increasing in Canada. We examined the true extent of the problem and the impact of the introduction of long-acting oxycodone...
  5. ncbi Morphine prevents the mitochondrial permeability transition pore opening through NO/cGMP/PKG/Zn2+/GSK-3beta signal pathway in cardiomyocytes
    Jinkun Xi
    Department of Anesthesiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Am J Physiol Heart Circ Physiol 298:H601-7. 2010
    ..In conclusion, morphine mobilizes intracellular Zn(2+) through the NO/cGMP/PKG signaling pathway and prevents the mPTP opening by inactivating GSK-3beta through Zn(2+)...
  6. ncbi Opioid complications and side effects
    Ramsin Benyamin
    Millennium Pain Center, Bloomington, IL 61701, USA
    Pain Physician 11:S105-20. 2008
    ..Opioids can be considered broad spectrum analgesic agents, affecting a wide number of organ systems and influencing a large number of body functions...
  7. ncbi State-dependent opioid control of pain
    Howard Fields
    University of California, 513 Parnassus Avenue, San Francisco, California 94143, USA
    Nat Rev Neurosci 5:565-75. 2004
  8. pmc Opioids for chronic noncancer pain: a meta-analysis of effectiveness and side effects
    Andrea D Furlan
    Comprehensive Pain Program, Toronto Western Hospital, Ont
    CMAJ 174:1589-94. 2006
    ..Chronic noncancer pain (CNCP) is a major health problem, for which opioids provide one treatment option. However, evidence is needed about side effects, efficacy, and risk of misuse or addiction...
  9. ncbi Increasing deaths from opioid analgesics in the United States
    Leonard J Paulozzi
    Division of Unintentional Injury Prevention, National Center for Injury Prevention and Control, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Pharmacoepidemiol Drug Saf 15:618-27. 2006
    ..During the same time period, the use of opioid analgesics has increased markedly as part of more aggressive pain management...
  10. pmc Use of opioid medications for chronic noncancer pain syndromes in primary care
    M Carrington Reid
    Clinical Epidemiology Unit, VA Connecticut Healthcare System, West Haven Conn 06516, USA
    J Gen Intern Med 17:173-9. 2002
    ..We also sought to determine the proportion of patients who manifested prescription opioid abuse behaviors and the factors associated with these behaviors...
  11. ncbi Local infiltration analgesia: a technique for the control of acute postoperative pain following knee and hip surgery: a case study of 325 patients
    Dennis R Kerr
    Joint Orthopaedic Centre, New South Wales, Australia
    Acta Orthop 79:174-83. 2008
    ..The technique allows virtually immediate mobilization and earlier discharge from hospital...
  12. ncbi Short-term infusion of the mu-opioid agonist remifentanil in humans causes hyperalgesia during withdrawal
    Martin S Angst
    Department of Anesthesia, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA
    Pain 106:49-57. 2003
    ..This study also points to a differential susceptibility of different pain modalities for the expression of hyperalgesia associated with opioid administration...
  13. ncbi Rates of adverse events of long-acting opioids in a state Medicaid program
    Daniel M Hartung
    College of Pharmacy, Oregon State University, Oregon Health and Science University Campus, Portland, OR 97239, USA
    Ann Pharmacother 41:921-8. 2007
    ..Despite widespread use and emerging safety concerns, data on the comparative safety and effectiveness of long-acting opioid (LAO) analgesics are weak...
  14. ncbi Induction of synaptic long-term potentiation after opioid withdrawal
    Ruth Drdla
    Department of Neurophysiology, Center for Brain Research, Medical University of Vienna, Spitalgasse 4, 1090 Vienna, Austria
    Science 325:207-10. 2009
    ..These findings provide a previously unrecognized target to selectively combat pro-nociceptive effects of opioids without compromising opioid analgesia...
  15. ncbi The development of a comprehensive risk-management program for prescription opioid analgesics: researched abuse, diversion and addiction-related surveillance (RADARS)
    Theodore J Cicero
    Washington University School of Medicine, St Louis, Missouri 63110, USA
    Pain Med 8:157-70. 2007
    ..Thus, its major focus was the detection of abuse of OxyContin and other commonly prescribed opioid analgesics at the three-digit ZIP code level across the country utilizing a number of different detection systems.
  16. ncbi Opioids in chronic non-cancer pain: systematic review of efficacy and safety
    Eija Kalso
    Pain Clinic, Department of Anaesthesia and Intensive Care Medicine, Helsinki University Central Hospital, P O Box 340, FIN 00029 HUS, Finland
    Pain 112:372-80. 2004
    ..The small number of selected patients and the short follow-ups do not allow conclusions concerning problems such as tolerance and addiction...
  17. ncbi Controlled-release oxycodone relieves neuropathic pain: a randomized controlled trial in painful diabetic neuropathy
    C Peter N Watson
    University of Toronto, Toronto, ON, Canada
    Pain 105:71-8. 2003
    ..Painful neuropathy is one of the most common long-term complications of diabetes mellitus and often proves difficult to relieve...
  18. ncbi Differential sensitivity of N- and P/Q-type Ca2+ channel currents to a mu opioid in isolectin B4-positive and -negative dorsal root ganglion neurons
    Zi Zhen Wu
    Department of Anesthesiology, H187, The Pennsylvania State University College of Medicine, 500 University Dr, Hershey, PA 17033 0850, USA
    J Pharmacol Exp Ther 311:939-47. 2004
    ..The differential sensitivity of voltage-gated Ca2+ channels to the mu opioids in subsets of DRG neurons may constitute an important analgesic mechanism of mu opioids...
  19. ncbi Facilitation of neonatal nasotracheal intubation with premedication: a randomized controlled trial
    J Oei
    Department of Newborn Care, Royal Hospital for Women, Randwick, Australia
    J Paediatr Child Health 38:146-50. 2002
    ..The experimental design was a non-blinded randomized controlled pilot trial. The setting was a perinatal centre in a university teaching hospital...
  20. ncbi Side effects of opioids during short-term administration: effect of age, gender, and race
    M Soledad Cepeda
    Department of Anesthesiology, and Clinical Epidemiology Unit Javeriana Univeristy, Bogota, Colombia
    Clin Pharmacol Ther 74:102-12. 2003
    ..Our objective was to evaluate the effect of the type of opioid, age, gender, and race on the incidence of side effects from short-term opioid use...
  21. ncbi Nucleus accumbens opioid, GABaergic, and dopaminergic modulation of palatable food motivation: contrasting effects revealed by a progressive ratio study in the rat
    Min Zhang
    Department of Psychiatry, University of Wisconsin Madison Medical School, 53715, USA
    Behav Neurosci 117:202-11. 2003
  22. ncbi Equianalgesic dose ratios for opioids. a critical review and proposals for long-term dosing
    J Pereira
    Division of Palliative Medicine, University of Calgary, Calgary, Alberta, T2N 2T9 Canada
    J Pain Symptom Manage 22:672-87. 2001
    ..The complexity of the clinical context in which many switches occur must be recognized and also appreciated in the design of future studies...
  23. ncbi A randomized controlled trial of interim methadone maintenance
    Robert P Schwartz
    Friends Research Institute, Inc, Baltimore, MD 21201, USA
    Arch Gen Psychiatry 63:102-9. 2006
    ..Effective alternatives to long waiting lists for entry into methadone hydrochloride maintenance treatment are needed to reduce the complications of continuing heroin dependence and to increase methadone treatment entry...
  24. pmc Reduced hospital stay, morphine consumption, and pain intensity with local infiltration analgesia after unicompartmental knee arthroplasty
    Per Essving
    Department of Orthopedic Surgery, University of Linkoping, Sweden
    Acta Orthop 80:213-9. 2009
    ..The degree of postoperative pain is usually moderate to severe following knee arthroplasty. We investigated the efficacy of local administration of analgesics into the operating area, both intraoperatively and postoperatively...
  25. ncbi Opioids in the management of chronic non-cancer pain: an update of American Society of the Interventional Pain Physicians' (ASIPP) Guidelines
    Andrea M Trescot
    American Society of Interventional Pain Physicians, Paducah, KY 42001, USA
    Pain Physician 11:S5-S62. 2008
    ..Available evidence suggests a continued wide variance in the use of opioids, as documented by different medical specialties, medical boards, advocacy groups, and the Drug Enforcement Administration...
  26. ncbi G protein-independent G1 cell cycle block and apoptosis with morphine in adenocarcinoma cells: involvement of p53 phosphorylation
    Irmgard Tegeder
    Pharmazentrum Frankfurt, Klinische Pharmakologie, Klinikum der Johann Wolfgang Goethe Universitat, 60590 Frankfurt am Main, Germany
    Cancer Res 63:1846-52. 2003
    ..Our results suggest that morphine, alone or in combination with Nx, may reduce the growth of certain tumors, apparently in part through activation of p53...
  27. ncbi Proteinase-activated receptor-2 mediates itch: a novel pathway for pruritus in human skin
    Martin Steinhoff
    Department of Physiology and Experimental Pathophysiology, University of Erlangen, 91054 Erlangen, Germany
    J Neurosci 23:6176-80. 2003
    ..PAR-2 therefore represents a promising therapeutic target for the treatment of cutaneous neurogenic inflammation and pruritus...
  28. ncbi Morphine analgesia suppresses tumor growth and metastasis in a mouse model of cancer pain produced by orthotopic tumor inoculation
    Takashi Sasamura
    Department of Applied Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    Eur J Pharmacol 441:185-91. 2002
    ..The results suggest that relief from cancer pain by morphine inhibits tumor growth and metastasis...
  29. ncbi A multimodal analgesia protocol for total knee arthroplasty. A randomized, controlled study
    Pascal André Vendittoli
    Orthopaedic Surgery Unit, Department of Surgery, Maisonneuve Rosemont Hospital, 5345 Boul L Assomption, Suite 55, Montreal, Quebec H1T 4B3, Canada
    J Bone Joint Surg Am 88:282-9. 2006
    ..This study was performed to evaluate the benefits and safety of a multimodal analgesia protocol that included periarticular injection of large doses of local anesthetics in patients undergoing total knee arthroplasty...
  30. ncbi Pharmacokinetics and efficacy of ropivacaine continuous wound instillation after joint replacement surgery
    M Bianconi
    Department of Anesthesiology and Intensive Care, St Anna Hospital Ferrara, Ferrara, Italy
    Br J Anaesth 91:830-5. 2003
  31. ncbi Role of receptor internalization in opioid tolerance and dependence
    Thomas Koch
    Department of Pharmacology and Toxicology, Otto von Guericke University, 39120 Magdeburg, Germany
    Pharmacol Ther 117:199-206. 2008
    ..Thus, clearer understanding of the role of opioid receptor trafficking in the regulation of opioid tolerance and dependence will help in the treatment of patients suffering from chronic pain or drug dependence...
  32. ncbi Enhancement of spinal N-methyl-D-aspartate receptor function by remifentanil action at delta-opioid receptors as a mechanism for acute opioid-induced hyperalgesia or tolerance
    Min Zhao
    Department of Anesthesia, and Program in Neurosciences and Mental Health, Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada
    Anesthesiology 109:308-17. 2008
  33. ncbi Opioid-induced hyperalgesia: abnormal or normal pain?
    Guy Simonnet
    Laboratoire Homéostasie Allostasie Pathologie, Universite Victor Segalen Bordeaux 2, France
    Neuroreport 14:1-7. 2003
  34. pmc Cellular neuroadaptations to chronic opioids: tolerance, withdrawal and addiction
    M J Christie
    Pain Management Research Institute and Kolling Institute, University of Sydney, Royal North Shore Hospital, St Leonards, NSW, Australia
    Br J Pharmacol 154:384-96. 2008
  35. ncbi Remifentanil versus alfentanil: comparative pharmacokinetics and pharmacodynamics in healthy adult male volunteers
    T D Egan
    Palo Alto Veterans Administration Medical Center, Palo Alto, California, USA
    Anesthesiology 84:821-33. 1996
    ..Remifentanil is an esterase-metabolized opioid with a rapid clearance. The aim of this study was to contrast the pharmacokinetics and pharmacodynamics of remifentanil and alfentanil in healthy, adult male volunteers...
  36. ncbi Nausea and vomiting side effects with opioid analgesics during treatment of chronic pain: mechanisms, implications, and management options
    Frank Porreca
    Department of Pharmacology, University of Arizona, Tuscon, Arizona 85724, USA
    Pain Med 10:654-62. 2009
    ..This review examines the mechanisms that produce these side effects, their impact on treatment outcomes in chronic pain patients, and counteractive strategies...
  37. ncbi Pharmacology of methadone and its isomers
    C E Inturrisi
    Department of Pharmacology, Weill Medical College of Cornell University, New York, NY 10021, USA
    Minerva Anestesiol 71:435-7. 2005
    ..Thus, the same dose of intrathecal d-methadone that attenuates the development of spinal morphine tolerance blocks NMDA-induced hyperalgesia in rats. These results support the..
  38. ncbi A murine model of opioid-induced hyperalgesia
    X Li
    Veterans Affairs Palo Alto Health Care System and Stanford University Department of Anesthesiology, 3801 Miranda Ave, Palo Alto, CA 94304, USA
    Brain Res Mol Brain Res 86:56-62. 2001
    ..Thus we have characterized a murine model of OIH which will be useful in the pursuit of the molecular mechanisms underlying this phenomenon...
  39. ncbi Efficacy of opioids for chronic pain: a review of the evidence
    Jane C Ballantyne
    Division of Pain Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Clin J Pain 24:469-78. 2008
    ..Mechanisms for loss of analgesic efficacy proposed are pharmacologic tolerance, opioid-induced hyperalgesia, subtle and intermittent withdrawal, and a number of psychologic factors including loss of the placebo component...
  40. ncbi Chronic pain and genetic background interact and influence opioid analgesia, tolerance, and physical dependence
    De Yong Liang
    Department of Anesthesia, Stanford University School of Medicine, Stanford, CA, USA
    Pain 121:232-40. 2006
    ..We conclude that chronic inflammatory pain and genetics interact to modulate the analgesic potency of morphine, tolerance, and physical dependence...
  41. pmc Alternative splicing controls G protein-dependent inhibition of N-type calcium channels in nociceptors
    Jesica Raingo
    Department of Neuroscience, Brown University, Sidney E Frank Hall for Life Sciences, 185 Meeting Street, Providence, Rhode Island 02912, USA
    Nat Neurosci 10:285-92. 2007
    ..Our data define the molecular origins of voltage-independent inhibition of N-type channels in the pain pathway...
  42. ncbi Benefit-risk assessment of transdermal fentanyl for the treatment of chronic pain
    Craig A Kornick
    Department of Neurology, Memorial Sloan Kettering Cancer Center, Pain and Palliative Care Service, New York, New York, USA
    Drug Saf 26:951-73. 2003
    ..Patients may resume such activities once the absence of these potential adverse effects is documented...
  43. ncbi Management of opioid side effects in cancer-related and chronic noncancer pain: a systematic review
    Ewan McNicol
    Department of Anesthesia, New England Medical Center and Tufts University School of Medicine, Boston, MA 02111, USA
    J Pain 4:231-56. 2003
    ..Well-designed trials in the specified populations are required to furnish clinicians with secure evidence on managing opioid side effects successfully...
  44. ncbi Significantly higher methadone dose for methadone maintenance treatment (MMT) patients with chronic pain
    Einat Peles
    The Dr Miriam and Sheldon G Adelson Clinic for Drug Abuse, Treatment and Research, Tel Aviv Elias Sourasky Medical Center, 1 Henrietta Szold Street, Tel Aviv 64924, Israel
    Pain 113:340-6. 2005
  45. ncbi Efficacy and safety of opioid agonists in the treatment of neuropathic pain of nonmalignant origin: systematic review and meta-analysis of randomized controlled trials
    Elon Eisenberg
    Pain Relief Unit, Rambam Medical Center, and Haifa Pain Research Group, The Technion Israel Institute of Technology, Haifa, Israel
    JAMA 293:3043-52. 2005
    ..The use of opioids for neuropathic pain remains controversial, in part because studies have been small, have yielded equivocal results, and have not established the long-term risk-benefit ratio of this treatment...
  46. ncbi Synergistic increases in intracellular Ca2+, and the release of MCP-1, RANTES, and IL-6 by astrocytes treated with opiates and HIV-1 Tat
    Nazira El-Hage
    Department of Anatomy and Neurobiology, University of Kentucky College of Medicine, Lexington, Kentucky 40536 0298, USA
    Glia 50:91-106. 2005
  47. ncbi Opioids and opioid receptors in the enteric nervous system: from a problem in opioid analgesia to a possible new prokinetic therapy in humans
    Peter Holzer
    Department of Experimental and Clinical Pharmacology, Medical University of Graz, Universitatsplatz 4, A 8010 Graz, Austria
    Neurosci Lett 361:192-5. 2004
    The gut is a neurological organ, which implies that many neuroactive drugs such as opioid analgesics can seriously disturb gastrointestinal function, because many of the transmitters and transmitter receptors present in the brain are ..
  48. ncbi The changing role of non-opioid analgesic techniques in the management of postoperative pain
    Paul F White
    Department of Anesthesiology and Pain Management, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9068, USA
    Anesth Analg 101:S5-22. 2005
    ..short-stay basis, anesthesiologists and surgeons should prescribe multimodal analgesic regimens that use non-opioid analgesics (e.g...
  49. ncbi Regulating opioid prescribing through prescription monitoring programs: balancing drug diversion and treatment of pain
    Scott M Fishman
    Division of Pain Medicine, Department of Anesthesiology and Pain Medicine, University of California, Davis, Sacramento, California 95817, USA
    Pain Med 5:309-24. 2004
    ..Future trends for PMPs are described, including the potential for widespread use of electronic prescribing, which is gaining favor with the Drug Enforcement Agency...
  50. ncbi Strategies for the treatment of cancer pain in the new millennium
    C Ripamonti
    Rehabilitation and Palliative Care Division, National Cancer Institute of Milan, Italy
    Drugs 61:955-77. 2001
    ..that may minimise the adverse effects which are often associated with the current therapeutic class of opioid analgesics. In addition, current research points to promising results identifying the N-methyl D-aspartate non-opioid ..
  51. ncbi Comparative actions of the opioid analgesics morphine, methadone and codeine in rat models of peripheral and central neuropathic pain
    Helle Kirsten Erichsen
    Department of Pharmacology, Neurosearch A S, 93 Pederstrupvej, DK 2750 Ballerup, Denmark
    Pain 116:347-58. 2005
    ..Our results further support the efficacy of mu-opioid receptor agonists in alleviating signs of neuropathic pain in animal models of peripheral and especially central nerve injury...
  52. pmc Geographic variation in the prescription of schedule II opioid analgesics among outpatients in the United States
    Lesley H Curtis
    Center for Clinical and Genetic Economics, Duke Clinical Research Institute, P O Box 17969, Durham, NC 27715, USA
    Health Serv Res 41:837-55. 2006
    ..To measure geographic variation in opioid use in a large, commercially insured, outpatient population in the United States...
  53. ncbi College on Problems of Drug Dependence taskforce on prescription opioid non-medical use and abuse: position statement
    James Zacny
    Department of Anesthesia and Critical Care, University of Chicago, Box MC4028, 5841 S Maryland Avenue, Chicago, IL 60637, USA
    Drug Alcohol Depend 69:215-32. 2003
  54. ncbi Oral transmucosal fentanyl citrate for the treatment of breakthrough pain in cancer patients: an overview of its pharmacological and clinical characteristics
    Kyriaki Mystakidou
    Department of Radiology, University of Athens, Athens, Greece
    Am J Hosp Palliat Care 22:228-32. 2005
    ..In particular, it is going to discuss the synthesis, clinical pharmacology, pharmacokinetic and pharmacodynamic properties, toxicity, and clinical efficacy of this novel agent...
  55. ncbi Prevalence and characteristics of chronic pain among chemically dependent patients in methadone maintenance and residential treatment facilities
    Andrew Rosenblum
    Institute for Treatment and Services Research, National Development and Research Institutes, New York, NY 10010, USA
    JAMA 289:2370-8. 2003
    ..Little is known about the prevalence and characteristics of chronic pain among patients with different types of chemical dependency...
  56. ncbi Transdermal fentanyl. A review of its pharmacological properties and therapeutic efficacy in pain control
    W Jeal
    Adis International Limited, Auckland, New Zealand
    Drugs 53:109-38. 1997
    ..The advantages offered by fentanyl TTS over traditional methods of chronic pain control include its ease of administration, less constipation and the 3-..
  57. pmc Dosage patterns in methadone treatment: results from a national survey, 1988-2005
    Harold A Pollack
    Center for Health Administration Studies, University of Chicago, 969 East 60th St, Chicago, IL 60637, USA
    Health Serv Res 43:2143-63. 2008
    ..To examine the extent to which U.S. methadone maintenance facilities meet established standards for minimum dosages, 1988-2005...
  58. ncbi Comparison of peri- and intraarticular analgesia with femoral nerve block after total knee arthroplasty: a randomized clinical trial
    Karen Toftdahl
    Department of Anesthesiology, Aarhus University Hospital, Denmark
    Acta Orthop 78:172-9. 2007
    ..Postoperative pain after total knee arthroplasty (TKA) can be difficult to manage and may delay recovery. Recent studies have suggested that periarticular infiltration with local anesthetics may improve outcome...
  59. ncbi Opioid analgesics and rates of fatal drug poisoning in the United States
    Leonard J Paulozzi
    Division of Unintentional Injury Prevention, National Center for Injury Prevention and Control, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Am J Prev Med 31:506-11. 2006
    To determine whether the variability in rate of sale of prescription opioid analgesics is related to the variability in rates of drug poisoning mortality among states in the United States in 2002.
  60. pmc EULAR evidence based recommendations for the management of hip osteoarthritis: report of a task force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT)
    W Zhang
    Academic Rheumatology, University of Nottingham, UK
    Ann Rheum Dis 64:669-81. 2005
    ..To develop evidence based recommendations for the management of hip osteoarthritis (OA)...
  61. ncbi Regulation of human affective responses by anterior cingulate and limbic mu-opioid neurotransmission
    Jon Kar Zubieta
    Department of Psychiatry and Mental Health Research Institute, University of Michigan, 205 Zina Pitcher Place, Ann Arbor, MI 48109 0720, USA
    Arch Gen Psychiatry 60:1145-53. 2003
    ..The mu-opioid neurotransmitter system is distributed in, and thought to regulate the function of, brain regions centrally implicated in affective processing...
  62. ncbi A qualitative and quantitative systematic review of preemptive analgesia for postoperative pain relief: the role of timing of analgesia
    Steen Møiniche
    Department of Anesthesiology, Herlev University Hospital, Herlev, Denmark
    Anesthesiology 96:725-41. 2002
  63. ncbi Transdermal fentanyl: an updated review of its pharmacological properties and therapeutic efficacy in chronic cancer pain control
    R B Muijsers
    Adis International Limited, Auckland, New Zealand
    Drugs 61:2289-307. 2001
    ..Adverse reactions related to skin and appendages (i.e. rash and application site reactions - erythema, papules, itching and oedema) were reported in 153 patients with cancer at a frequency between 1 and 3%...
  64. ncbi Opioid tolerance and hyperalgesia
    Grace Chang
    Massachusetts General Hospital Pain Center, Division of Pain Medicine, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Med Clin North Am 91:199-211. 2007
    ..This article will review updated information from both clinical and preclinical studies regarding opioid-induced hyperalgesia, tolerance, and dependence. The implications of these issues in clinical opioid therapy also will be discussed...
  65. ncbi Placebo and opioid analgesia-- imaging a shared neuronal network
    Predrag Petrovic
    Cognitive Neurophysiology Research Group, Department of Clinical Neuroscience, Karolinska Institute, Stockholm 171 76, Sweden, Pain Clinic, Department of Anaesthesia and Intensive Care Medicine, Helsinki University Hospital, Finland
    Science 295:1737-40. 2002
    ..These findings indicate a related neural mechanism in placebo and opioid analgesia...
  66. ncbi Opioid therapy for chronic noncancer back pain. A randomized prospective study
    R N Jamison
    Department of Anesthesia, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Spine (Phila Pa 1976) 23:2591-600. 1998
    ..Opioid therapy for chronic back pain was used without significant risk of abuse. However, tapered-off opioid treatment is palliative and without long-term benefit...
  67. ncbi Sex-specific responses to opiates: animal and human studies
    Albert Dahan
    Department of Anesthesiology, Leiden University Medical Center, P5 Q, 2300 RC Leiden, The Netherlands
    Anesth Analg 107:83-95. 2008
  68. ncbi Stereoselective metabolism of methadone N-demethylation by cytochrome P4502B6 and 2C19
    John G Gerber
    Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Chirality 16:36-44. 2004
  69. ncbi Efficacy of duloxetine, a potent and balanced serotonergic and noradrenergic reuptake inhibitor, in inflammatory and acute pain models in rodents
    Carrie K Jones
    Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN 46285, USA
    J Pharmacol Exp Ther 312:726-32. 2005
    ..Our data indicate that duloxetine may be efficacious in the treatment of persistent and/or inflammatory pain states at doses that have modest or no effect on acute nociception or motor performance...
  70. ncbi Preventive effects of perioperative parecoxib on post-discectomy pain
    G Riest
    Klinik für Anästhesiologie und Intensivmedizin, Universitaetsklinikum Essen, Germany
    Br J Anaesth 100:256-62. 2008
    ..Cyclooxygenase inhibitor treatment is viewed increasingly critical because of safety considerations, and there are several open questions on their optimal use...
  71. ncbi Receptor endocytosis counteracts the development of opioid tolerance
    Thomas Koch
    Department of Pharmacology and Toxicology, Otto von Guericke University, 39120 Magdeburg, Leipziger Strasse 44, Germany
    Mol Pharmacol 67:280-7. 2005
    ..Our findings suggest that opioids with high endocytotic efficacies might cause reduced opioid tolerance but can facilitate compensatory mechanisms, resulting in an enhanced opioid dependence...
  72. ncbi Oral transmucosal fentanyl citrate: randomized, double-blinded, placebo-controlled trial for treatment of breakthrough pain in cancer patients
    J T Farrar
    University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    J Natl Cancer Inst 90:611-6. 1998
    ..We conducted a multicenter, randomized, double-blinded, placebo-controlled trial of OTFC for cancer-related breakthrough pain...
  73. ncbi Explaining the escalation of drug use in substance dependence: models and appropriate animal laboratory tests
    Gerald Zernig
    Experimental Psychiatry Unit, Department of Psychiatry, Medical University Innsbruck, Innsbruck, Austria
    Pharmacology 80:65-119. 2007
    ..The review concludes by making suggestions on how to improve the current behavioral experimental approaches...
  74. ncbi Reduced hospital stay and narcotic consumption, and improved mobilization with local and intraarticular infiltration after hip arthroplasty: a randomized clinical trial of an intraarticular technique versus epidural infusion in 80 patients
    Karen V Andersen
    Department of Orthopedic Surgery, Aarhus University Hospital, Aarhus, Denmark
    Acta Orthop 78:180-6. 2007
    ..We compared wound infiltration combined with intraarticular injection of local anesthetics for pain relief after total hip arthroplasty (THA) with the well-established practice of epidural infusion...
  75. ncbi Sex differences in opioid analgesia: "from mouse to man"
    Rebecca M Craft
    Clin J Pain 19:175-86. 2003
    ..Additionally, methodological issues in research into opioid sex differences are discussed...
  76. ncbi Regulation of opioid receptor trafficking and morphine tolerance by receptor oligomerization
    Li He
    Ernest Gallo Clinic and Research Center, University of California San Francisco, Emeryville, CA 94608, USA
    Cell 108:271-82. 2002
    ..These results demonstrate that endocytosis of the MOR can reduce the development of tolerance, and hence suggest an approach for the development of opiate analogs with enhanced efficacy for the treatment of chronic pain...
  77. ncbi Profound, non-opioid analgesia produced by the high-efficacy 5-HT(1A) agonist F 13640 in the formalin model of tonic nociceptive pain
    L Bardin
    Centre de Recherche Pierre Fabre, 17 avenue Jean Moulin, F 81106 Castres Cedex, France
    Pharmacology 67:182-94. 2003
  78. ncbi Management of common opioid-induced adverse effects
    John M Swegle
    Mercy Family Medicine Residency Program, Mason City, Iowa 50401 2859, USA
    Am Fam Physician 74:1347-54. 2006
    b>Opioid analgesics are useful agents for treating pain of various etiologies; however, adverse effects are potential limitations to their use...
  79. ncbi Torsade de pointes associated with very-high-dose methadone
    Mori J Krantz
    Denver Health Medical Center, and the University of Colorado Health Sciences Center, Bannock Street, Mailcode 0960, Denver, CO 80204 4507, USA
    Ann Intern Med 137:501-4. 2002
    ..A methadone derivative, levacetylmethadol, was withdrawn from the European market after being associated with torsade de pointes. To date, no association between methadone and this arrhythmia has been described...
  80. pmc Differential activation and trafficking of micro-opioid receptors in brain slices
    Seksiri Arttamangkul
    Vollum Institute, L474, Department of Behavioral Neuroscience, Oregon Health Sciences University, 3181 W Sam Jackson Park Dr, Portland, OR 97239, USA
    Mol Pharmacol 74:972-9. 2008
  81. ncbi Genetic variation in morphine analgesic tolerance: a survey of 11 inbred mouse strains
    Benjamin Kest
    Department of Psychology and Center for Developmental Neuroscience, The College of Staten Island, City University of New York, Staten Island, NY 10314, USA
    Pharmacol Biochem Behav 73:821-8. 2002
    ..The present work demonstrates that the presence and magnitude of morphine analgesic tolerance is genotype-dependent and identifies strains with widely divergent liabilities that should facilitate identification of trait-relevant genes...
  82. ncbi Opioid analgesics in primary care: challenges and new advances in the management of noncancer pain
    Raymond Sinatra
    Yale University School of Medicine, New Haven, CT 06510, USA
    J Am Board Fam Med 19:165-77. 2006
    ..The article identifies for primary care physicians the current challenges and issues surrounding the use of opioid analgesics for noncancer pain and examines how new technology and expanding knowledge have been applied to existing ..
  83. ncbi Vasorelaxant effect of opioid analgesics on the isolated human radial artery
    S Gursoy
    Department of Anesthesiology, Cumhuriyet University School of Medicine, Sivas, Turkey
    Eur J Anaesthesiol 23:496-500. 2006
    Arterial grafts are prone to vasospasm. Opioid analgesics are commonly used in the perioperative course of cardiac surgical procedures...
  84. ncbi Methadone and buprenorphine for the management of opioid dependence: a systematic review and economic evaluation
    M Connock
    Department of Public Health and Epidemiology, University of Birmingham, UK
    Health Technol Assess 11:1-171, iii-iv. 2007
    ..To assess the clinical effectiveness and cost-effectiveness of buprenorphine maintenance therapy (BMT) and methadone maintenance therapy (MMT) for the management of opioid-dependent individuals...
  85. ncbi Monoamine oxidase inhibitors, opioid analgesics and serotonin toxicity
    P K Gillman
    Pioneer Valley Private Hospital, Mackay, Queensland, Australia
    Br J Anaesth 95:434-41. 2005
    ..There are a number of lesser-known drugs that are MAOIs, such as linezolid and moclobemide; and some opioid analgesics have serotonergic activity...
  86. ncbi Long-term use of controlled-release oxycodone for noncancer pain: results of a 3-year registry study
    Russell K Portenoy
    Department of Pain Medicine and Palliative Care, Beth Israel Medical Center, New York, NY 10003, USA
    Clin J Pain 23:287-99. 2007
    ..To evaluate the outcomes associated with the use of controlled-release (CR) oxycodone for up to 3 years in the treatment of noncancer pain...
  87. ncbi Comparative efficacy and safety of long-acting oral opioids for chronic non-cancer pain: a systematic review
    Roger Chou
    Department of Medicine, Oregon Health and Science University, and Oregon Evidence Based Practice Center, Portland, Oregon, USA
    J Pain Symptom Manage 26:1026-48. 2003
    ..A subgroup of three studies on long-acting versus short-acting oxycodone was more homogeneous and provided fair evidence that these formulations are equally effective for pain control...
  88. ncbi P-glycoprotein ATPase activating effect of opioid analgesics and their P-glycoprotein-dependent antinociception in mice
    Wakako Hamabe
    Department of Pharmacology, Wakayama Medical University, 811 1 Kimiidera, Wakayama City, Wakayama 641 8509, Japan
    Pharmacol Biochem Behav 85:629-36. 2006
    It is well known that opioid analgesics exert central antinociceptive actions...
  89. ncbi Physician-related barriers to cancer pain management with opioid analgesics: a systematic review
    Ramune Jacobsen
    Department of Pharmacology and Pharmacotherapy, Faculty of Pharmaceutical Sciences, University of Copenhagen, Denmark
    J Opioid Manag 3:207-14. 2007
    The purpose of this review is to summarize the results of studies on physician-related barriers to cancer pain management with opioid analgesics.
  90. pmc Morphine and alternative opioids in cancer pain: the EAPC recommendations
    G W Hanks
    Palliative Medicine, University of Bristol, Bristol Haematology and Oncology Centre, UK
    Br J Cancer 84:587-93. 2001
    ..The revised recommendations presented here give guidance on the use of morphine and the alternative strong opioid analgesics which have been introduced in many parts of the world in recent years...
  91. ncbi Opioids in chronic non-cancer pain, indications and controversies
    Harald Breivik
    Department of Anaesthesiology, Rikshospitalet University Hospital, N 0027 Oslo, Norway
    Eur J Pain 9:127-30. 2005
    The use of opioid analgesics for long term management of chronic non-cancer pain is now an accepted, although still a controversial medical practice...
  92. ncbi Efficacy and safety of scheduled dosing of opioid analgesics: a quality improvement study
    Judith A Paice
    Department of Medicine, Division of Hematology Oncology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Pain 6:639-43. 2005
    ..a quality improvement study was conducted to determine the efficacy and safety of scheduled dosing of opioid analgesics, using a 2-group parallel design...
  93. ncbi The burden of the nonmedical use of prescription opioid analgesics
    Aaron M Gilson
    WHO Collaborating Center for Policy and Communications in Cancer Care, University of Wisconsin School of Medicine and Public Health, Madison, 53711 1068, USA
    Pain Med 10:S89-100. 2009
    ..Such resources, along with an accurate understanding of the problem, extend greater hope that the public health challenge of nonmedical prescription opioid use can be effectively mitigated...
  94. pmc Integrins regulate opioid receptor signaling in trigeminal ganglion neurons
    K A Berg
    Department of Pharmacology, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    Neuroscience 144:889-97. 2007
    ..g. Galphai vs. Galphas). Collectively, these data provide the first evidence that specific integrins regulate opioid receptor signaling in sensory neurons...
  95. ncbi Variability in emergency physician decision making about prescribing opioid analgesics
    Joshua H Tamayo-Sarver
    Case Western Reserve University School of Medicine, Cleveland, OH, USA
    Ann Emerg Med 43:483-93. 2004
    ..The purpose of this study is to determine what factors influence emergency physicians' decisions to prescribe an opioid analgesic for 3 common, painful conditions...
  96. ncbi Quantifying morbidity associated with the abuse and misuse of opioid analgesics: a comparison of two approaches
    Meredith Y Smith
    Purdue Pharma L P, One Stamford Forum, Stamford, Connecticut 06901 3431, USA
    Clin Toxicol (Phila) 45:23-30. 2007
    Due to the rising nonmedical use of opioid analgesics, methods are needed to quantify the associated health-related consequences.
  97. ncbi Opioids block long-term potentiation of inhibitory synapses
    Fereshteh S Nugent
    Brown University, Department of Molecular Pharmacology, Physiology and Biotechnology, Providence, Rhode Island 02912, USA
    Nature 446:1086-90. 2007
    ..These neuroadaptations to opioid drugs might contribute to early stages of addiction, and may potentially be exploited therapeutically using drugs targeting GABA(A) receptors...
  98. ncbi Mu opioid receptor-effector coupling and trafficking in dorsal root ganglia neurons
    W M Walwyn
    Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California at Los Angeles, NPI Box 77, 760 Westwood Plaza, Los Angeles, CA 90024 1759, USA
    Neuroscience 142:493-503. 2006
    ..Such ligand-independent desensitization could be a result of the observed higher rate of synthesis and degradation of this chimeric receptor...
  99. ncbi Trends in consumption of opioid analgesics in Slovak Republic during 1998-2002
    R Hudec
    Department of Pharmacology, School of Medicine, Comenius University, Sasinkova 4, 81372 Bratislava, Slovakia
    Eur J Clin Pharmacol 60:445-8. 2004
    ..To describe the patterns of consumption in an opioid analgesic group in Slovakia between 1998 and 2002, to determine prescription habits, and to compare the results with those from selected countries...
  100. ncbi [Use of opioid analgesics in diagnosis and decision-making in patients with acute nontraumatic abdominal pain. A systematic review of the literature]
    Carlos Manterola
    Departamento de Cirugia, Facultad de Medicina, Universidad de La Frontera, Temuco, Chile
    Cir Esp 81:91-5. 2007
    ..The aim of the present study was to determine whether the use of opioid analgesics in patients with acute nontraumatic abdominal pain increases the risk of diagnostic error.
  101. ncbi Lack of analgesic effect of parecoxib following laparoscopic cholecystectomy
    P A E Puolakka
    Department of Anaesthesiology, University Hospital, Tampere, Finland
    Acta Anaesthesiol Scand 50:1027-32. 2006
    ..We studied the effect of a single dose of parecoxib of either 40 or 80 mg in laparoscopic cholecystectomy, and its effect on opioid-induced side-effects...

Research Grants75

  1. Morphine versus Methadone as First Line Strong Opioid for Cancer Pain
    Eduardo Bruera; Fiscal Year: 2009
    ..The great majority of these patients will require opioid analgesics for appropriate pain control...
  2. Hyperalgesia in Methadone Patients: Can it be Treated?
    Margaret Compton; Fiscal Year: 2007
    ..tolerance, in addition to the contextual prohibitions associated with providing known opioid addicts with opioid analgesics, makes them a population uniquely vulnerable to the under treatment of pain...
  3. Opioid and Cannabinoid Pharmacokinetic Interactions
    Donald Abrams; Fiscal Year: 2007
    ..a study to investigate the effects of smoked cannabis on the pharmacokinetics and metabolism of widely used opioid analgesics. The trial will be conducted among experienced marijuana users prescribed opiates for cancer-related pain...
  4. Pain, Opioids, and Sleep in Cancer Patients
    Kathy Parker; Fiscal Year: 2006
    ..Furthermore, sleep disturbances may lead to increased subjective sensations of pain. Opioid analgesics are known to have intrinsic properties that negatively affect sleep quality...
  5. Virtual Relaxation Environment for Chronic Back Pain
    Libby Tannenbaum; Fiscal Year: 2004
    ..Pharmacological agents such as opioid analgesics have proven effective, however, the risk of physical and psychological dependence is a problem, particularly ..
  6. Improving pain and function in hip fracture
    R Sean Morrison; Fiscal Year: 2013
    ..Physicians are reluctant to prescribe opioid analgesics to geriatric patients for fear of precipitating side effects (e.g...
  7. 18F-beta-Endorphin Imaging: Translational Study of an Opioid Peptide Radiotracer
    BRIAN contact REED; Fiscal Year: 2010
    ..agonist at 5-opioid receptors (MOP-r), the target of addictive opioids such as heroin and prescription opioid analgesics such as oxycodone and morphine...
  8. Impact CYP2D6 Phenotype on Response to Methamphetamine in Humans
    Alison Oliveto; Fiscal Year: 2013
    ..typically demonstrating a greater risk for and severity of dependence on drugs such as nicotine and certain opioid analgesics than poor metabolizers (PMs)...
  9. Central Mechanisms of Orofacial Pain
    Jianren Mao; Fiscal Year: 2012
    ..of treating orofacial pain with non-steroidal anti-inflammatory drugs, tricyclic antidepressants, and opioid analgesics is often limited by these drugs'side effects and, in some cases, unwanted long-term consequences...
  10. Immune and Gilia Regulation of Pain &Analgesic Actions
    Linda Watkins; Fiscal Year: 2012
    ..Pain facilitation via neuron-to-glia signaling;NIDA R01 (Watkins PI;3/05-12/09;DA017670);(d) Opioid analgesics: modulation...
  11. Opioid selection and the risk of serious infections in older adults
    Carlos G Grijalva; Fiscal Year: 2013
    ..A number of opioid analgesics are currently available, but not all have the same immunosuppressive properties...
  12. Design, Synthesis and Evaluation of Novel Isoform-Selective Sodium Channel Inhibi
    JOHN VINCENT MULCAHY; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Side effects associated with opioid analgesics, such as nausea, drowsiness, respiratory depression, and potential for addiction, are motivating the design and development of new therapies for acute, ..
  13. Strategies for Prescribing Analgesics Comparative Effectiveness (SPACE) Trial
    ERIN ELIZABETH KREBS; Fiscal Year: 2013
    ..Although evidence supports the ability of opioid analgesics to produce short-term reductions in pain intensity, long-term trials evaluating opioid effectiveness are not ..
  14. Blood-to-CNS Drug Uptake in Pain
    THOMAS PAUL DAVIS; Fiscal Year: 2013
    ..Our hypothesis is that changes in transport of commonly prescribed opioid analgesics and novel therapeutic opioid peptides will occur due to alterations in the functional expression of putative ..
  15. Effectiveness of Mandatory Prescription Drug Monitoring
    Guohua Li; Fiscal Year: 2012
    ..that the majority of unintentional overdose morbidity and mortality are attributable to nonmedical use of opioid analgesics and benzodiazepines obtained from diversion and 'doctor shopping...
  16. Naloxone prescription for Opioid Safety Evaluation (NOSE)
    Phillip O Coffin; Fiscal Year: 2013
    ..S. This dramatic shift has been attributed to opioid analgesic overdose;deaths from opioid analgesics have exceeded the combined overdose deaths from heroin and cocaine since 2003...
  17. Medications and the Risk of Sudden Cardiac Death
    Wayne A Ray; Fiscal Year: 2013
    ..for chronic pain, the risk of sudden cardiac death in methadone users is greater than that for comparable opioid analgesics. 3...
  18. Analgesics targeting truncated 6transmembrane exon 11 variants of MOR-1 (6TM-E11)
    Susruta Majumdar; Fiscal Year: 2013
    ..I propose to use it as a lead compound to design a library of opioid analgesics. In spite of its favorable pharmacology, its selectivity for the new target over the traditional ones is ..
  19. Role of the Supraspinal Opioidergic Circuit in Prefrontal TMS-Induced Analgesia
    JOSEPH JEFFREY TAYLOR; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Opioid analgesics that are prescribed for pain management pose a significant health risk in terms of abuse potential and dose-dependent side effects...
  20. Transcranial Direct Current Stimulation in the Management of Post-operative Pain
    Jeffrey J Borckardt; Fiscal Year: 2013
    ..Additionally, systemic opioid analgesics have associated side-effects that can lead to post-operative complications including but not limited to ..
  21. Unique Opioid Analgesics With No Addiction Liability or Dysphoria
    John A Lawson; Fiscal Year: 2011
    ..However, the problems associated with morphine and other standard opioid analgesics are well characterized...
  22. Mu opioid agonists with reduced side effects for the treatment of pain
    Chad E Groer; Fiscal Year: 2011
    ..The proposed research is designed to develop a novel class of opioid analgesics that produce less tolerance and may potentially reduce opiate-associated side effects...
  23. Predictors of Opioid Analgesic Responses and Common Endogenous Opioid Mechanisms
    John W Burns; Fiscal Year: 2013
    ..Use of opioid analgesics for management of nonmalignant chronic pain has increased dramatically, yet is fraught with controversy due ..
  24. Persistent Pain and Opioid Mechanisms in the Rostroventral Medial Medulla
    MARLENE CANO; Fiscal Year: 2011
    ..to adaptive changes in the RVM that change the balance of these pathways and that increase the potency of opioid analgesics. Investigation of the mechanisms by which 5 opioid receptor (MOPr) agonists suppress acute nociception and ..
  25. Central Nervous System Delivery of Opioid Peptides
    JOHN HOEKMAN; Fiscal Year: 2012
    ..Administration of traditional mu-opioid analgesics presents numerous problems, including gastrointestinal side effects, drug-drug interactions with other CNS ..
    Peter W Schiller; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): There is an urgent clinical need for the development of opioid analgesics with novel biological activity profiles that lack the limiting side effects of currently available opiates...
  27. Cannabinergic Ligands and Drugs
    Alexandros Makriyannis; Fiscal Year: 2012
    ..The long-term goals of this application are to develop: (a) novel therapeutic medications for the treatment of cannabis, nicotine and stimulant abuse and (b) novel non-opioid analgesics devoid of undesirable side effects.
  28. Pathophysiology of postoperative delirium in older patients
    Jacqueline M Leung; Fiscal Year: 2013
    ..delirium is strongly related to the severity of pain, and probably to the central nervous system effects of opioid analgesics, the usual therapy for postoperative pain...
  29. Pain, Opioids And Pro-Inflammatory Immune Responses
    MARGARET ANN COMPTON; Fiscal Year: 2010
    ..and opioid administration co-occur, as is the common clinical case of a patient with acute pain and taking opioid analgesics. An additive model would predict that pro-inflammatory processes are increased in the presence of both, yet ..
  30. International Conference on Nausea and Vomiting 2013
    Bill J Yates; Fiscal Year: 2013
    ..to gastroparesis, pregnancy, cyclic vomiting syndrome, motion sickness, and drug responses (chemotherapy, opioid analgesics) using genetic, electrophysiological, neuroimaging, and electronic patient reporting approaches...
  31. Delta-Opioid Receptor Trafficking and Pain Inhibition
    Zhizhong Z Pan; Fiscal Year: 2012
    ..Currently, opioid analgesics, mainly mu-opioid receptor (MOR) agonists such as morphine and fentanyl, are still the most effective pain ..
  32. Neurobiology and Treatment of Pain
    SIDNEY S NEGUS; Fiscal Year: 2013
    ..Pain is a significant public health problem, and opioid analgesics constitute a principal class of drugs used to treat pain...
  33. Prescribed Opioid Safety in Children
    Wayne A Ray; Fiscal Year: 2013
    ..suggest this epidemic now possibly affects children: the proportion of children 2-17 years old prescribed opioid analgesics increased from 5% in 1996 to 11% in 2007, with a comparable trend in medical care possibly consistent with ..
  34. Optimizing Pain Treatment while Reducing Abuse Liability in Opioid Dependence
    David Andrew Tompkins; Fiscal Year: 2013
    ..analgesic properties and abuse liability measurements in persons with opioid dependence after exposure to opioid analgesics. This application is for a K23 Mentored Patient-Oriented Research Career Development Award for Dr...
  35. Adolescent Oxycodone Self Administration and Vulnerability to Opiate Abuse
    Yong Zhang; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Abuse of prescription opioid analgesics (such as oxycodone) has become a major health concern in the United States and occurs mostly in adolescents and young adults...
  36. Caregiving Skills in Effective Medication Management for Hospice Patients
    DENYS LAU; Fiscal Year: 2011
    ..aims to better understand the skills necessary for effective management of medication regimens, including opioid analgesics, among informal caregivers of hospice patients living at home...
  37. Ligands that target opioid-chemokine and opioid-mGlu5 heteromers
    Philip S Portoghese; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Opioid analgesics remain the drug of choice for management of acute and chronic pain...
  38. Synthesis of Alpha2/Alpha3 GABA Agonists to Treat Neuropathic Pain
    James M Cook; Fiscal Year: 2013
    ..An eventual goal is to replace the addictive opioid analgesics with these safer, non addictive ligands for treatment of all types of neuropathic and inflammatory pain, in ..
  39. Novel Glycosylated Delta Opioid Receptor Agonists for Chronic Inflammatory Pain
    Mark S Kleven; Fiscal Year: 2012
    ..broad-spectrum analgesic efficacy with greatly reduced side effects compared to the currently used MOR opioid analgesics. The glycosylation of DOR selective peptides also represents a BBI platform technology that improves ..
  40. Opioid Use, Physical Function, Falls, and Fracture in Older Men
    ERIN ELIZABETH KREBS; Fiscal Year: 2013
    ..applicant): Older adults are disproportionately affected by musculoskeletal pain conditions and receive more opioid analgesics than younger persons, but benefits and harms of opioid therapy for persistent musculoskeletal pain in older ..
  41. Phosphoproteomics of Opioid Tolerance
    GEORGE LATIMER WILCOX; Fiscal Year: 2010
    ..The Public Health Relevance: Tolerance to opioid analgesics remains a key factor limiting access of chronic pain sufferers to adequate relief...
  42. Synthesis and Evaluation of Functionally Biased Opioid Analgesics
    Laura M Bohn; Fiscal Year: 2013
    ..The information garnered from this proposal will prove useful in the future development of clinical pain relievers with limited side effects. ..
  43. Pharmacological Studies of NOP Receptors
    Mei Chuan Ko; Fiscal Year: 2013
    ..Behavioral effects of NOP receptor agonists will be systematically compared with those of mu opioid analgesics across different, well-established functional/behavioral assays in monkeys...
  44. Mindfulness-Oriented Recovery Enhancement For Chronic Pain Patients Receiving Opi
    ERIC LEE GARLAND; Fiscal Year: 2012
    ..As many as 18% of patients become addicted to prescribed opioid analgesics, and nearly one quarter of chronic pain patients display signs of opioid misuse which may herald the ..
    THOMAS PAUL DAVIS; Fiscal Year: 2013
    ..The treatment of pain (both acute/post-surgical and chronic) often involves opioid analgesics. We have shown that peripheral inflammatory pain (PIP) promotes BBB dysfunction characterized by changes in ..
  46. Mechanisms of Opioid-Induced Hyperalgesia in Pain Patients: Examination via fMRI
    Jarred W Younger; Fiscal Year: 2012
    b>Opioid analgesics are some of the most commonly prescribed medications in the United States, and are being Increasingly used for chronic pain management...
  47. Synthesis and pharmacology of novel opiates and their modulatory systems
    Gavril W Pasternak; Fiscal Year: 2012
    ..Sigma1 agonists potently reverse the analgesic activity of a variety of classes of opioid analgesics while sigma1 antagonists potentiate opioid analgesia...
  48. Impact of pain on sensitivity to opioid reward
    Zhizhong Z Pan; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: Repeated use of opioid analgesics for control of chronic pain has the potential to cause compulsive behaviors of opioid misuse and addiction ..
  49. Agonist-Directed MOR Desensitization in Opioid Analgesic Tolerance
    Laura M Bohn; Fiscal Year: 2010
    ..The Public Health Relevance: Our studies are designed to explore the feasibility of designing new opioid analgesics that we predict will produce less analgesic tolerance and limited side effects such as constipation and ..
  50. High throughput in vivo screening: translational generation of novel analgesics
    Richard A Houghten; Fiscal Year: 2013
    ..Marketed opioid analgesics are both potent and effective, but are strongly addictive with potentially life- threatening side effects...
  51. Evaluation of a community-based initiative to prevent opioid overdose
    Christopher L Ringwalt; Fiscal Year: 2013
    ..poisoning are rising rapidly as a consequence of both the medical and non-medical use of prescribed opioid analgesics. Project Lazarus, which was created to respond to North Carolina's epidemic of abuse of opioid ..
  52. Synaptic mechanisms for interactions of chronic pain and opioid addiction
    Zhizhong Z Pan; Fiscal Year: 2013
    ..weighing on physicians'decisions on prescribing opioids of long-term, thus limiting the optimal use of opioid analgesics for maximum pain control...
  53. Human Brain Functional and Structural Interactions Between Chronic Pain and Opioi
    Hans C Breiter; Fiscal Year: 2011
    ..no history of chronic pain, (ii) individuals with chronic pain who have developed addictive behaviors toward opioid analgesics, (iii) individuals with chronic pain who have treatment based exposure to analgesics but no addiction ..
  54. Trajectories of Nonmedical Prescription Drug Misuse
    Sean Esteban McCabe; Fiscal Year: 2013
    ..e., opioid analgesics, stimulants, tranquilizers) has significantly increased over the past two decades in the United States and ..
  55. The effects of acetaminophen on the rewarding properties of hydrocodone in rats
    Arbi Nazarian; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The illicit abuse of prescription opioid analgesics has been on the rise in recent years. This illicit use has been associated to the rewarding/reinforcing properties of opioid agonists...
  56. Development and Validation of a Computerized Opioid Overdose Intervention
    Kelly E Dunn; Fiscal Year: 2013
    ..Fatal OD from opioid analgesics specifically has increased over 400% between 1999 and 2008, and nonfatal overdose occurs at a rate 3-7 ..
  57. Intervention to Promote Opioid Treatment Agreements in Primary Care
    Joanna L Starrels; Fiscal Year: 2013
    ..treatment agreements (OTAs) to define treatment and monitoring plans for patients prescribed long-term opioid analgesics for chronic pain...
  58. Transforming Clinical Pain Control by Targeting a Novel Non-Neuronal Receptor
    Hang Yin; Fiscal Year: 2010
    ..may eventually find application in the development of novel therapeutics to enhance the clinical efficacy of opioid analgesics and to treat opioid addiction and abuse, as well as other clinically relevant indications...
  59. Bivalent ligands as molecular probes for CB1/OX1 receptor heterodimers
    Yanan Zhang; Fiscal Year: 2010
    ..systemic administration, but did not produce the tolerance or dependence seen with traditional monovalent opioid analgesics. This provides an excellent example of the utility of our proposed approach...
  60. Psychoactive Medications: Associations with Delirium Persistance vs Resolution
    Edward Marcantonio; Fiscal Year: 2009
    ..classes of psychoactive medications: 1) sedative-hypnotics, 2) antipsychotics, 3) anticholinergics, and 4) opioid analgesics, with delirium persistence over a one-month time period...
  61. N-of-1 Trials Using mHealth in Chronic Pain
    Richard L Kravitz; Fiscal Year: 2013
    ..In usual practice, clinicians resort to opioid analgesics, often reluctantly, when other drugs are seemingly ineffective or contraindicated...
    Jon Levine; Fiscal Year: 2006
    ..Despite considerable research on gender differences in pain sensitivity, sex differences in pain modulation by opioid analgesics in humans have only recently been examined...
  63. Opioid-induced Hyperalgesia in Prescription Opioid Abusers: Effects of Pregabalin
    Margaret A Compton; Fiscal Year: 2013
    ..1 million prescription opioid abusers in this country suffer pain on an ongoing basis, yet treatment with opioid analgesics is complicated not only by concerns about drug-seeking and addiction, but also by the neurophysiologic ..
  64. Development of a Novel Class for Opioid Drugs
    NIKOLAY DOKHOLYAN; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The mu-opioid receptor (MOR) is the primary target for opioid analgesics. While opioids are the most frequently used and effective analgesics for the treatment of moderate to severe clinical pain, ..
    Gavril W Pasternak; Fiscal Year: 2013
    ..We recently generated a series of opioid analgesics with unique pharmacological profiles and found that they act through a novel receptor target involving a ..
  66. Clinical and Genetic Characteristics of Opioid Addiction in Chronic Pain
    Martin D Cheatle; Fiscal Year: 2013
    ..regarding the mu opioid receptor (MOR) gene (OPRM1) as critical to the rewarding and analgesic properties of opioid analgesics. It is the specific aim of this project to perform genome-wide analysis in approximately 2,000 patients with ..
  67. Acupuncture to Prevent Postoperative Paralytic lleus
    JOSEPH CHIANG; Fiscal Year: 2004
    ..compare post-surgical quality of life status between treatment and control groups in terms of pain, use of opioid analgesics, nausea, vomiting, insomnia, abdominal distention/fullness, activity, and sense of well-being; and 2) ..
  68. Safety and Efficacy of Patient Controlled Analgesia in the Emergency Department
    Polly Bijur; Fiscal Year: 2009
    ..Inadequate ED pain management has been well documented. Opioid analgesics constitute the standard treatment of acute pain, however there are numerous obstacles to optimal use of ..
  69. Herb-Opioid Interactions
    Danny Shen; Fiscal Year: 2003
    ..Johns wort as a "mood enhancer" and natural antidepressant, cancer pain patients receiving opioid analgesics may well turn to this herbal preparation for relief of depressive symptoms...
  70. Peripheral Nerve Blocks with Multimodal Analgesics
    Brian Williams; Fiscal Year: 2009
    ..Such a block would further advance opioid-sparing analgesia, and aim to reduce patient dependence on opioid analgesics as the primary mechanism of analgesia in the first week(s) after orthopedic surgery...
  71. Race in Physician Decision to Prescribe Opioid Analgesia
    JOSHUA SARVER; Fiscal Year: 2002
    ..Phase 1 of this study will determine clinical factors that influence physicians? decisions to prescribe opioid analgesics for the 3 conditions (regardless of patients? race/ethnicity) using individual physician interviews and a ..
  72. Novel Glycosylated Delta Opioid Receptor Agonists for Chronic Inflammatory Pain
    KIMBERLEY GANNON; Fiscal Year: 2009
    ..PUBLIC HEALTH RELEVANCE: Although opioid analgesics such as morphine remain the standard of care for moderate to severe, acute and chronic pain, they are ..
  73. Development of Opioid Receptor Models for Rational Design of Bifunctional Ligands
    JUDITH HOBRATH; Fiscal Year: 2009
    ..The use of these mu agonist opioid analgesics is severely restricted by a number of serious side effects such as development of tolerance and dependence ..
  74. 38th Annual International Narcotics Research Conference
    Jean Bidlack; Fiscal Year: 2007
    ..There will also be sessions dedicated to the biosynthesis and functional efficacy of new opioid analgesics as well as opioid receptor signaling and regulation by scaffolding/signaling complexes...
  75. Eptifibatide as Treatment for Acute Pain Episodes in Sickle Cell Disease
    Kenneth Ataga; Fiscal Year: 2009
    ..of the pathophysiology of SCD, the treatment of acute pain episodes remains inadequate, consisting mainly of opioid analgesics. The UNC Sickle Cell Program offers a large and closely followed patient population in whom we will be able ..