analgesics

Summary

Summary: Compounds capable of relieving pain without the loss of CONSCIOUSNESS or without producing ANESTHESIA.

Top Publications

  1. ncbi Survey of chronic pain in Europe: prevalence, impact on daily life, and treatment
    Harald Breivik
    University of Oslo, Faculty of Medicine, Faculty Division Rikshospitalet, Department of Anaesthesiology, Rikshospitalet University Hospital, Norway
    Eur J Pain 10:287-333. 2006
  2. ncbi Animal models of nociception
    D Le Bars
    INSERM U 161, 2, rue d Alesia, 75014 Paris, France
    Pharmacol Rev 53:597-652. 2001
  3. ncbi Treatment of neuropathic pain: an overview of recent guidelines
    Alec B O'Connor
    Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Am J Med 122:S22-32. 2009
  4. pmc Roles of reactive oxygen and nitrogen species in pain
    Daniela Salvemini
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, St Louis, MO 63104, USA
    Free Radic Biol Med 51:951-66. 2011
  5. ncbi Spinal cord mechanisms of pain
    R D'Mello
    Department of Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
    Br J Anaesth 101:8-16. 2008
  6. ncbi Descending control of pain
    Mark J Millan
    Department of Psychopharmacology, Institut de Recherches Servier, 125 Chemin de Ronde, 78290 Croissy Seine, Paris, France
    Prog Neurobiol 66:355-474. 2002
  7. pmc Central and peripheral sites of action for CB₂ receptor mediated analgesic activity in chronic inflammatory and neuropathic pain models in rats
    Gin C Hsieh
    Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA
    Br J Pharmacol 162:428-40. 2011
  8. pmc Management of primary chronic headache in the general population: the Akershus study of chronic headache
    Espen Saxhaug Kristoffersen
    Head and Neck Research Group, Research Centre, Akershus University Hospital, 1478 Lørenskog, Oslo, Norway
    J Headache Pain 13:113-20. 2012
  9. ncbi Chronic daily headache with analgesic overuse: epidemiology and impact on quality of life
    R Colas
    Health Center of Santoña, University Hospital Marqués de Valdecilla UC, Cantabria, Spain
    Neurology 62:1338-42. 2004
  10. ncbi Morphine, gabapentin, or their combination for neuropathic pain
    Ian Gilron
    Department of Anesthesiology, Queen s University, Kingston, Ont, Canada
    N Engl J Med 352:1324-34. 2005

Detail Information

Publications376 found, 100 shown here

  1. ncbi Survey of chronic pain in Europe: prevalence, impact on daily life, and treatment
    Harald Breivik
    University of Oslo, Faculty of Medicine, Faculty Division Rikshospitalet, Department of Anaesthesiology, Rikshospitalet University Hospital, Norway
    Eur J Pain 10:287-333. 2006
    ..g,. massage (30%), physical therapy (21%), acupuncture (13%). Almost half were taking non-prescription analgesics; 'over the counter' (OTC) NSAIDs (55%), paracetamol (43%), weak opioids (13%)...
  2. ncbi Animal models of nociception
    D Le Bars
    INSERM U 161, 2, rue d Alesia, 75014 Paris, France
    Pharmacol Rev 53:597-652. 2001
    ..It is concluded that although the neural basis of the most used tests is poorly understood, their use will be more profitable if pain is considered within, rather than apart from, the body's homeostatic mechanisms...
  3. ncbi Treatment of neuropathic pain: an overview of recent guidelines
    Alec B O'Connor
    Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Am J Med 122:S22-32. 2009
    ..e., gabapentin and pregabalin), and topical lidocaine. Opioid analgesics and tramadol were recommended as second-line treatments that can be considered for first-line use in selected ..
  4. pmc Roles of reactive oxygen and nitrogen species in pain
    Daniela Salvemini
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, St Louis, MO 63104, USA
    Free Radic Biol Med 51:951-66. 2011
    ..research in this area is poised to provide the pharmacological basis for development of novel nonnarcotic analgesics that are based upon the unique ability to selectively eliminate SO and/or PN...
  5. ncbi Spinal cord mechanisms of pain
    R D'Mello
    Department of Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
    Br J Anaesth 101:8-16. 2008
    ..In this review, we consider the ways in which spinal cord activity may be altered in chronic pain states. In addition, we discuss the spinal mechanisms which are targeted by current analgesics used in the management of chronic pain.
  6. ncbi Descending control of pain
    Mark J Millan
    Department of Psychopharmacology, Institut de Recherches Servier, 125 Chemin de Ronde, 78290 Croissy Seine, Paris, France
    Prog Neurobiol 66:355-474. 2002
    ..Knowledge of descending pathways has increased exponentially in recent years, so this is an opportune moment to survey their operation and therapeutic relevance to the improved management of pain...
  7. pmc Central and peripheral sites of action for CB₂ receptor mediated analgesic activity in chronic inflammatory and neuropathic pain models in rats
    Gin C Hsieh
    Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA
    Br J Pharmacol 162:428-40. 2011
    ..The present study was conducted to elucidate the CB₂ receptor expression in 'pain relevant' tissues and the potential sites of action of CB₂ agonism in rats...
  8. pmc Management of primary chronic headache in the general population: the Akershus study of chronic headache
    Espen Saxhaug Kristoffersen
    Head and Neck Research Group, Research Centre, Akershus University Hospital, 1478 Lørenskog, Oslo, Norway
    J Headache Pain 13:113-20. 2012
    ..Thus, avoidance of acute headache medication overuse and increased use of prophylactic medication may improve the management of primary chronic headaches in the future...
  9. ncbi Chronic daily headache with analgesic overuse: epidemiology and impact on quality of life
    R Colas
    Health Center of Santoña, University Hospital Marqués de Valdecilla UC, Cantabria, Spain
    Neurology 62:1338-42. 2004
    ..To analyze the prevalence and demography of chronic daily headache (CDH) with analgesic overuse...
  10. ncbi Morphine, gabapentin, or their combination for neuropathic pain
    Ian Gilron
    Department of Anesthesiology, Queen s University, Kingston, Ont, Canada
    N Engl J Med 352:1324-34. 2005
    ..We compared the efficacy of a combination of gabapentin and morphine with that of each as a single agent in patients with painful diabetic neuropathy or postherpetic neuralgia...
  11. ncbi Plants with central analgesic activity
    R N Almeida
    Laborat6rio de Tecnologia Farmacêutica, Universidade Federal da Paraiba, Joao Pessoa, Brazil
    Phytomedicine 8:310-22. 2001
    ..One hundred and sixty six plants belonging to 79 families are reported...
  12. ncbi Gabapentin for the symptomatic treatment of painful neuropathy in patients with diabetes mellitus: a randomized controlled trial
    M Backonja
    Department of Neurology, University of Wisconsin, Madison 53792, USA
    JAMA 280:1831-6. 1998
    ..Pain is the most disturbing symptom of diabetic peripheral neuropathy. As many as 45% of patients with diabetes mellitus develop peripheral neuropathies...
  13. ncbi Chronic daily headache in Taipei, Taiwan: prevalence, follow-up and outcome predictors
    S R Lu
    Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan
    Cephalalgia 21:980-6. 2001
    ..TM was the most common subtype (55%), followed by CTTH (44%). Thirty-four per cent of the CDH subjects overused analgesics. At the 2-year follow-up, 35% of the CDH subjects still had CDH...
  14. pmc Alterations in endocannabinoid tone following chemotherapy-induced peripheral neuropathy: effects of endocannabinoid deactivation inhibitors targeting fatty-acid amide hydrolase and monoacylglycerol lipase in comparison to reference analgesics following c
    Josee Guindon
    Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN 47405 2204, United States
    Pharmacol Res 67:94-109. 2013
    ..Thus, inhibition of endocannabinoid hydrolysis, via FAAH or MGL inhibitors, represents an efficacious pharmacological approach for suppressing chemotherapy-induced neuropathic pain...
  15. ncbi Pharmacological characterization of standard analgesics on mechanical allodynia in streptozotocin-induced diabetic rats
    Hiroko Yamamoto
    Pharmacology Research Laboratories, Astellas Pharma Inc, Tsukuba, Ibaraki 305 8585, Japan
    Neuropharmacology 57:403-8. 2009
    ..Their efficacies varied depending on the duration of the diabetic condition, suggesting that temporal changes in pharmacodynamic factors could affect the responsiveness of this model to analgesic agents...
  16. ncbi Efficacy of antidepressants as analgesics: a review
    Pinky Dharmshaktu
    Department of Pharmacology, Maulana Azad Medical College, Bahadur Shah Zafar Marg, Delhi, India 110002
    J Clin Pharmacol 52:6-17. 2012
    ..pain disorders are usually not adequately alleviated by nonsteroidal anti-inflammatory drugs or other simple analgesics. Use of antidepressants as adjuvant therapy for the control of persistent pain is currently being practiced in ..
  17. ncbi Mu-conotoxins as leads in the development of new analgesics
    Raymond S Norton
    Walter and Eliza Hall Institute of Medical Research, Victoria, Australia
    Molecules 15:2825-44. 2010
    ..pain perception and mu-conotoxins are able to block these channels, mu-conotoxins show considerable potential as analgesics. Recent studies have advanced our understanding of the three-dimensional structures and structure-function ..
  18. ncbi Review of current guidelines on the care of postherpetic neuralgia
    Charles E Argoff
    Albany Medical College, Albany, NY 12208, USA
    Postgrad Med 123:134-42. 2011
    ....
  19. ncbi Need for analgesics/drugs of abuse: a comparison between headache patients and addicts by the Leeds Dependence Questionnaire (LDQ)
    A Ferrari
    Headache Centre, Division of Toxicology and Clinical Pharmacology, University of Modena and Reggio Emilia, Modena, Italy
    Cephalalgia 26:187-93. 2006
    Our aim was to compare the need for analgesics/drugs of abuse between headache patients--chronic and episodic headache sufferers--and addicts, by the Leeds Dependence Questionnaire (LDQ)...
  20. ncbi Randomised clinical trial: pregabalin attenuates experimental visceral pain through sub-cortical mechanisms in patients with painful chronic pancreatitis
    S S Olesen
    Mech Sense, Department of Gastroenterology, Aalborg Hospital, Aarhus University Hospital, Denmark
    Aliment Pharmacol Ther 34:878-87. 2011
    ..Pregabalin has a broad spectrum of analgesic and antihyperalgesic activity in both basic and clinical studies. However, its mechanisms and sites of action have yet to be determined in humans...
  21. ncbi Acetyl-L-carnitine increases artemin level and prevents neurotrophic factor alterations during neuropathy
    E Vivoli
    Department of Preclinical and Clinical Pharmacology, University of Florence, Viale Pieraccini 6, 50139, Florence, Italy
    Neuroscience 167:1168-74. 2010
    ..These data offer a new point of view on the mechanism of the antihyperalgesic as well as the neuroprotective effect of ALCAR...
  22. ncbi Quality of life impairment, disability and economic burden associated with chronic daily headache, focusing on chronic migraine with or without medication overuse: a systematic review
    Michel Lanteri-Minet
    Département d Evaluation et traitement de la Douleur Médecine palliative, Pôle neurosciences cliniques, CHU de Nice Hôpital Pasteur, 30 Avenue de la Voie Romaine, Nice Cedex 1, France
    Cephalalgia 31:837-50. 2011
    ..To evaluate the evidence for quality of life (QoL) impairment, disability, healthcare resource use and economic burden associated with chronic daily headache (CDH), focusing on chronic migraine (CM) with or without medication overuse...
  23. ncbi Hypernociceptive role of cytokines and chemokines: targets for analgesic drug development?
    Waldiceu A Verri
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto University of Sao Paulo, Av Bandeirantes, 3900, 14049 900, Ribeirao Preto, SP, Brazil
    Pharmacol Ther 112:116-38. 2006
    ....
  24. ncbi Reactive oxygen species (ROS) play an important role in a rat model of neuropathic pain
    Hee Kee Kim
    Department of Neuroscience and Cell Biology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 1069, USA
    Pain 111:116-24. 2004
    ..Thus this study suggests that systemic administration of non-toxic doses of free radical scavengers could be useful for treatment of neuropathic pain...
  25. ncbi Acute pain
    D B Carr
    Department of Anesthesia and Medicine, Tufts University School of Medicine, New England Medical Center, Boston, MA 02111, USA
    Lancet 353:2051-8. 1999
    ..Hence, acute pain and other types of pain (cancer-related or chronic) that are classified as distinct actually have many similarities...
  26. ncbi Epidemiology of chronic daily headache
    J Pascual
    Service of Neurology, University Hospital Marques de Valdecilla, Santander 39008, Spain
    Curr Pain Headache Rep 5:529-36. 2001
    ..to data from specialized clinics, only around a quarter of CDH subjects in the general population overuse analgesics; the prevalence of CDH subjects with analgesic overuse being 1.1% to 1.9% of the general population...
  27. ncbi Medications associated with probable medication overuse headache reported in a tertiary care headache center over a 15-year period
    Chelsea A Meskunas
    Princeton University, Molecular Biology, NJ, USA
    Headache 46:766-72. 2006
    ..To evaluate the substances associated with medication overuse headache (MOH) in a headache center, over the course of the past 15 years...
  28. ncbi Blockade of central cyclooxygenase (COX) pathways enhances the cannabinoid-induced antinociceptive effects on inflammatory temporomandibular joint (TMJ) nociception
    Dong K Ahn
    Department of Oral Physiology and BrainKorea21, School of Dentistry, Kyungpook National University, Daegu, Republic of Korea
    Pain 132:23-32. 2007
    ..Based on our observations, combined administration of cannabinoids with COX inhibitors may hold a therapeutic promise in the treatment of inflammatory TMJ pain...
  29. ncbi Epidemiology of medication overuse headache in the general Swedish population
    Pernilla Jonsson
    University of Gothenburg, Sweden
    Cephalalgia 31:1015-22. 2011
    ..The aim was to estimate the prevalence of medication overuse headache (MOH) in Sweden and to analyze the occurrence of this disorder in different population groups...
  30. ncbi Chronic migraine in the population: burden, diagnosis, and satisfaction with treatment
    Marcelo E Bigal
    Merck Research Laboratories, 1 Merck Drive, Whitehouse Station, NJ 08889, USA
    Neurology 71:559-66. 2008
    ..To evaluate the disability profile and patterns of treatment and health care use for chronic migraine (CM) in the general population, in contrast to episodic migraine...
  31. ncbi Naturally occurring antinociceptive substances from plants
    J B Calixto
    Department of Pharmacology, CCB, Universidade Federal de Santa Catarina, Florianopolis, SC, Brazil
    Phytother Res 14:401-18. 2000
    ..that has occurred in recent years in the development of therapy, there is still a need for effective and potent analgesics, especially for the treatment of chronic pain...
  32. ncbi Intrathecal ziconotide in the treatment of refractory pain in patients with cancer or AIDS: a randomized controlled trial
    Peter S Staats
    Division of Pain Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    JAMA 291:63-70. 2004
    ..Ziconotide (formerly SNX-111) selectively blocks N-type voltage-sensitive calcium channels and may be effective in patients with pain that is refractory to opioid therapy or those with intolerable opioid-related adverse effects...
  33. pmc Sociodemographic differences in medication use, health-care contacts and sickness absence among individuals with medication-overuse headache
    Pernilla Jonsson
    Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    J Headache Pain 13:281-90. 2012
    ..Particular efforts should be directed towards those with low educational levels, and more research on medication use in relation to age is required...
  34. ncbi Depression-like behavior and mechanical allodynia are reduced by bis selenide treatment in mice with chronic constriction injury: a comparison with fluoxetine, amitriptyline, and bupropion
    Cristiano R Jesse
    Laboratorio de Sintese, Reatividade e Avaliação Farmacológica e Toxicológica de Organocalcogênios, Centro de Ciencias Naturais e Exatas, Universidade Federal de Santa Maria, CEP 97105 900, Santa Maria, RS, Brazil
    Psychopharmacology (Berl) 212:513-22. 2010
    ..Pain co-morbidity symptoms are rarely assessed in animal models of neuropathic pain. Neuropathic pain is characterized by hyperexcitability within nociceptive pathways and remains difficult to treat with standard analgesics.
  35. ncbi Pharmacological assessment of the rat formalin test utilizing the clinically used analgesic drugs gabapentin, lamotrigine, morphine, duloxetine, tramadol and ibuprofen: influence of low and high formalin concentrations
    Gordon Munro
    Department of Pharmacology, Neurosearch A S, Ballerup, Denmark
    Eur J Pharmacol 605:95-102. 2009
    ....
  36. ncbi TRPA1 antagonists as potential analgesic drugs
    E L Andrade
    Departamento de Farmacologia, Universidade Federal de Santa Catarina, Florianopolis, Santa Catarina, Brazil
    Pharmacol Ther 133:189-204. 2012
    ..We also discuss recent advances in the search for new analgesic medicines targeting the TRPA1 channel...
  37. ncbi Medication use in patients with migraine and medication-overuse headache: the role of problem-solving and attitudes about pain medication
    Emelien Lauwerier
    Department of Experimental Clinical and Health Psychology, Ghent University, Ghent, Belgium
    Pain 152:1334-9. 2011
    ..Repeated attempts at solving pain may increase the need for analgesic medication, despite obvious costs. This mechanism might contribute to the problem of medication-overuse headache...
  38. ncbi Neurotoxicity of subarachnoid preservative-free S(+)-ketamine in dogs
    Lyvia Maria R S Gomes
    Department of Anesthesiology and Pain, Federal University of Maranhao, Brazil
    Pain Physician 14:83-90. 2011
    ..Subarachnoid S(+)-ketamine is a matter of much debate as the results regarding its toxicity are contradictory...
  39. ncbi Analgesics in patients with hepatic impairment: pharmacology and clinical implications
    Marija Bosilkovska
    Division of Clinical Pharmacology and Toxicology, Geneva University Hospitals, Geneva, Switzerland
    Drugs 72:1645-69. 2012
    ..The pharmacology of analgesics is also altered in liver disease...
  40. ncbi Intrauterine exposure to mild analgesics during pregnancy and the occurrence of cryptorchidism and hypospadia in the offspring: the Generation R Study
    Claudia A Snijder
    The Generation R Study Group, Erasmus University Medical Centre, Dr Molewaterplein 50 60, 3015 GE Rotterdam, The Netherlands
    Hum Reprod 27:1191-201. 2012
    ..We examined the influence of maternal exposure to mild analgesics during pregnancy on the occurrence of cryptorchidism and hypospadia in their offspring.
  41. ncbi Advances in neuropathic pain: diagnosis, mechanisms, and treatment recommendations
    Robert H Dworkin
    Department of Anesthesiology, University of Rochester School of Meedicine and Dentistry, Rochester, NY 14642
    Arch Neurol 60:1524-34. 2003
    ..Randomized controlled clinical trials of gabapentin, the 5% lidocaine patch, opioid analgesics, tramadol hydrochloride, and tricyclic antidepressants provide an evidence-based approach to the treatment of ..
  42. ncbi The adverse event profile of pregabalin: a systematic review and meta-analysis of randomized controlled trials
    Gaetano Zaccara
    U O Neurologia, Azienda Sanitaria di Firenze, Firenze, Italy
    Epilepsia 52:826-36. 2011
    ..We also assessed the association between serious AEs and pregabalin, and investigated whether pregabalin AEs display a dose-response relationship...
  43. pmc The antinociceptive and anti-inflammatory activities of caulerpin, a bisindole alkaloid isolated from seaweeds of the genus Caulerpa
    Everton Tenório de Souza
    LaFI Laboratório de Farmacologia e Imunidade, Instituto de Ciências Biológicas e da Saúde, Universidade Federal de Alagoas, Maceió AL, Brazil
    Mar Drugs 7:689-704. 2009
    ..3%. Pharmacological studies are continuing in order to characterize the mechanism(s) responsible for the antinociceptive and anti-inflammatory actions and also to identify other active principles present in Caulerpa racemosa...
  44. pmc Reporting randomised clinical trials of analgesics after traumatic or orthopaedic surgery is inadequate: a systematic review
    Eva Montané
    Fundacio Institut Catala de Farmacologia, Clinical Pharmacology Service, Hospital Universitari Vall d Hebron, Pg Vall d Hebron, no 119 129, 08035 Barcelona, Universitat Autonoma de Barcelona, Spain
    BMC Clin Pharmacol 10:2. 2010
    Several randomised clinical trials (RCTs) of analgesics in postoperative pain after traumatic or orthopaedic surgery (TOS) have been published, but no studies have assessed the quality of these reports...
  45. ncbi Modulation of TRPV1-dependent contractility of normal and diabetic bladder smooth muscle by analgesic toxins from sea anemone Heteractis crispa
    Igor B Philyppov
    Bogomoletz Institute of Physiology of the National Academy of Sciences of Ukraine, Kyiv, Ukraine
    Life Sci 91:912-20. 2012
    ..Our aim was to investigate the effects of two novel polypeptide inhibitors of TRPV1 from the venom of tropical sea anemone Heteractis crispa, APHC1 and APHC3, on the contractions of DSM from bladders of normal and diabetic rats...
  46. ncbi Do intraoperative analgesics influence oncological outcomes after radical prostatectomy for prostate cancer?
    Patrice Forget
    Department of Anesthesiology, Cliniques Universitaires Saint Luc, Universite Catholique de Louvain, Brussels, Belgium
    Eur J Anaesthesiol 28:830-5. 2011
    The potential impact of intraoperative analgesics on oncological outcome after radical prostatectomy is debated...
  47. pmc A TRPA1 antagonist reverts oxaliplatin-induced neuropathic pain
    Cristina Nativi
    Dipartimento di Chimica, Universita di Firenze, Polo Scientifico e Tecnologico, Sesto Fiorentino, Firenze, Italy
    Sci Rep 3:2005. 2013
    ....
  48. ncbi Monoterpenes with analgesic activity--a systematic review
    Adriana G Guimarães
    Departamento de Fisiologia, Universidade Federal de Sergipe DFS UFS, Sao Cristovao, SE, Brazil
    Phytother Res 27:1-15. 2013
    ..Forty-five papers were found concerning the potential analgesic activity of 27 monoterpenes. The data reviewed here suggest these compounds are possible candidates for the treatment of painful conditions...
  49. pmc Prevalence of medication overuse headache in an interdisciplinary pain clinic
    Corinne Wanner Schmid
    Institute of Anesthesiology, University Hospital of Zurich, Ramistrasse 100, Zurich 8091, Switzerland
    J Headache Pain 14:4. 2013
    ..The aim was the evaluation of the diagnostic criteria of MOH in a mixed population of chronic pain patients to gain information about the prevalence and possible associations with MOH...
  50. ncbi Pregabalin reduces pain in patients with chronic pancreatitis in a randomized, controlled trial
    Søren Schou Olesen
    Mech Sense, Department of Gastroenterology, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark
    Gastroenterology 141:536-43. 2011
    ..We investigated whether agents used to treat patients with neuropathic pain are effective in CP...
  51. pmc Diagnostic testing and treatment of low back pain in United States emergency departments: a national perspective
    Benjamin W Friedman
    Department of Emergency Medicine, Albert Einstein College of Medicine, Bronx, NY 10467, USA
    Spine (Phila Pa 1976) 35:E1406-11. 2010
    ..This study is an analysis of the National Hospital Ambulatory Medical Care Survey (NHAMCS), a large sample representative of all emergency department (ED) visits throughout the United States...
  52. pmc Transcriptional repression of the M channel subunit Kv7.2 in chronic nerve injury
    Kirstin Rose
    Institute of Membrane and Systems Biology, Faculty of Biological Science, University of Leeds, Leeds, UK
    Pain 152:742-54. 2011
    ..Our work suggests a novel mechanism for neuropathic overexcitability and brings focus on M channels and REST as peripheral targets for the treatment of neuropathic pain...
  53. ncbi Metabotropic glutamate receptors and the control of chronic pain
    Santina Chiechio
    Department of Drug Sciences, University of Catania, Italy
    Curr Opin Pharmacol 12:28-34. 2012
    ....
  54. pmc Chronic migraine plus medication overuse headache: two entities or not?
    Andrea Negro
    Department of Medical and Molecular Sciences, Sapienza University, Rome, Italy
    J Headache Pain 12:593-601. 2011
    ..Furthermore, it provided an injection paradigm that can be used as a guide for a correct administration of onabotulinumtoxinA...
  55. ncbi Medication overuse headache: rates and predictors for relapse in a 4-year prospective study
    Z Katsarava
    Department of Neurology, University Hospital Essen, Essen, Germany
    Cephalalgia 25:12-5. 2005
    ..70%, P<or=0.027) and also lower in patients overusing triptans than analgesics (21% vs. 71%, P<or=0.001)...
  56. ncbi Antinociceptive activity of discretamine isolated from Duguetia moricandiana
    J R G S Almeida
    Núcleo de Estudos e Pesquisas de Plantas Medicinais, Universidade Federal do Vale do São Francisco, 56 304 205, Petrolina, Pernambuco, Brazil
    Nat Prod Res 25:1908-15. 2011
    ..The effect of discretamine on hot plate response provides a confirmation of its central effect. These results indicate antinociceptive properties of this alkaloid...
  57. ncbi Nortriptyline and gabapentin, alone and in combination for neuropathic pain: a double-blind, randomised controlled crossover trial
    Ian Gilron
    Department of Anesthesiology, Queen s University, Kingston, ON, Canada
    Lancet 374:1252-61. 2009
    ..Drugs for neuropathic pain have incomplete efficacy and dose-limiting side-effects when given as monotherapy. We assessed the efficacy and tolerability of combined nortriptyline and gabapentin compared with each drug given alone...
  58. pmc Pregabalin suppresses spinal neuronal hyperexcitability and visceral hypersensitivity in the absence of peripheral pathophysiology
    Kirsty Bannister
    Department of Neuroscience, Pharmacology and Physiology, University College London, London, UK
    Anesthesiology 115:144-52. 2011
    ....
  59. ncbi Prostaglandin E2 and pain--an update
    Atsufumi Kawabata
    Division of Pharmacology and Pathophysiology, School of Pharmacy, Kinki University, Higashi Osaka 577 8502, Japan
    Biol Pharm Bull 34:1170-3. 2011
    ..synthase-1 and subtype-selective antagonists of PGE(2) receptors, particularly EP(1) and EP(4), may be useful as analgesics with minimized side-effects...
  60. ncbi Risk factors in medication-overuse headache: a 1-year follow-up study (care II protocol)
    G Sances
    Headache Unit and University Centre for Adaptive Disorders and Headache, University of Pavia, Pavia, Italy
    Cephalalgia 30:329-36. 2010
    ..000), and return to overused drug(s) (P = 0.000). The 1-year relapse rate was 22%. The existence of sub-groups of MOH patients with such risk factors could influence treatment strategies...
  61. pmc Headache and migraine in primary care: consultation, prescription, and referral rates in a large population
    R Latinovic
    Division of Health and Social Care Research, King s College London, 5 Lambeth Walk, London SE11 6SP, UK
    J Neurol Neurosurg Psychiatry 77:385-7. 2006
    ..Headache is the most common new neurological symptom seen by general practitioners and neurologists. This study describes headache consultation, prescription, and referral rates in a large sample of UK general practices...
  62. pmc Effect of a second-generation alpha2delta ligand (pregabalin) on visceral sensation in hypersensitive patients with irritable bowel syndrome
    L A Houghton
    Neurogastroenterology Unit, Academic Division of Medicine and Surgery, University of Manchester, Wythenshawe Hospital, Southmoor Road, Wythenshawe, Manchester M23 9LT, UK
    Gut 56:1218-25. 2007
    ..Pre-clinical studies suggest that the alpha(2)delta ligand pregabalin reduces both visceral allodynia and hyperalgesia, but is inactive on basal sensitivity...
  63. ncbi What predicts the change from episodic to chronic migraine?
    Marcelo E Bigal
    Merck Research Laboratories, Merck, Inc, Whitehouse Station, New Jersey, USA
    Curr Opin Neurol 22:269-76. 2009
    ..Because migraine worsens in a sizeable subgroup of sufferers, but not in most, identifying factors that predict the change from episodic into chronic migraine is of extreme interest and should be seen as a priority in headache research...
  64. pmc R-flurbiprofen reduces neuropathic pain in rodents by restoring endogenous cannabinoids
    Philipp Bishay
    Pharmazentrum frankfurt ZAFES, Clinical Pharmacology, Goethe University, Frankfurt, Germany
    PLoS ONE 5:e10628. 2010
    ..R-flurbiprofen, one of the enantiomers of flurbiprofen racemate, is inactive with respect to cyclooxygenase inhibition, but shows analgesic properties without relevant toxicity. Its mode of action is still unclear...
  65. ncbi Patterns of medication use by chronic and episodic headache sufferers in the general population: results from the frequent headache epidemiology study
    A I Scher
    Department of Preventive Medicine and Biometrics, Uniformed Services University, Bethesda, MD 20814, USA
    Cephalalgia 30:321-8. 2010
    ..4-0.9)]. After adjusting for demographic factors, primary headache type and number of medications taken, CDH sufferers are more likely to use opioid-combination analgesics, and less likely to use aspirin or ibuprofen, than EH sufferers.
  66. ncbi CB2 cannabinoid receptor-mediated peripheral antinociception
    T P Malan
    Department of Anesthesiology and Pharmacology, University of Arizona, Tucson, AZ 85724, USA
    Pain 93:239-45. 2001
    ..Peripheral antinociception without CNS effects is consistent with the peripheral distribution of CB(2) receptors. CB(2) receptor agonists may have promise clinically for the treatment of pain without CNS cannabinoid side effects...
  67. ncbi An analysis of factors that contribute to the magnitude of placebo analgesia in an experimental paradigm
    D D Price
    Departments of Oral and Maxillofacial Surgery and Neuroscience, University of Florida, P O Box 100416, Gainesville, FL 32610 0416, USA
    Pain 83:147-56. 1999
    ..Taken together, these results suggest that magnitudes of placebo effect are dependent on multiple factors, including conditioning, expectancy, and whether analgesia is assessed concurrently or retrospectively...
  68. ncbi Efficacy and safety of combination therapy with 5% lidocaine medicated plaster and pregabalin in post-herpetic neuralgia and diabetic polyneuropathy
    Ralf Baron
    Division of Neurological Pain Research and Therapy, Department of Neurology, Universitatsklinikum Schleswig Holstein, Campus Kiel, Kiel, Germany
    Curr Med Res Opin 25:1677-87. 2009
    ....
  69. ncbi Analgesic usage for low back pain: impact on health care costs and service use
    Molly T Vogt
    University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Spine (Phila Pa 1976) 30:1075-81. 2005
    ..Cross-sectional analysis of analgesic use by patients with low back pain (LBP)...
  70. pmc A narrative review on the management of medication overuse headache: the steep road from experience to evidence
    Paolo Rossi
    IRCCS Neurological Institute C Mondino Foundation, University Centre for Headache and Adaptive Disorders UCADH, Pavia Section, Pavia, Italy
    J Headache Pain 10:407-17. 2009
    ....
  71. ncbi Therapeutic potential of vanilloid receptor TRPV1 agonists and antagonists as analgesics: Recent advances and setbacks
    Gilbert Y Wong
    Clinical Research, Anesiva, South San Francisco, CA 94080, USA
    Brain Res Rev 60:267-77. 2009
    ..Hence, both agonists and antagonists of TRPV1 are being evaluated as potential analgesics in clinical trials...
  72. ncbi Fibromyalgia: Moderate and substantial pain intensity reduction predicts improvement in other outcomes and substantial quality of life gain
    R Andrew Moore
    Pain Research and Nuffield Department of Anaesthetics, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Pain 149:360-4. 2010
    ..Pain intensity reduction is a simple and effective predictor of which patients should continue treatment, and which should discontinue and try an alternative therapy...
  73. pmc Peripheral mechanisms of pain and analgesia
    Christoph Stein
    Department of Anesthesiology and Critical Care Medicine, Charite Campus Benjamin Franklin, Freie Universitat Berlin, Germany
    Brain Res Rev 60:90-113. 2009
    ..function and do not cross the blood-brain-barrier, centrally mediated untoward side effects of conventional analgesics (e.g. opioids, anticonvulsants) may be avoided...
  74. ncbi Recommendations for the management of herpes zoster
    Robert H Dworkin
    Department of Anesthesiology, University of Rochester School of Medicine and Dentistry, Rochester, NY, 14642, USA
    Clin Infect Dis 44:S1-26. 2007
    ..Specific recommendations for the use of these medications are provided. In addition, suggestions are made for treatments that, when used in combination with antiviral therapy, may further reduce pain and other complications of HZ...
  75. ncbi How "bad" does the pain have to be? A qualitative study examining adherence to pain medication in older adults with osteoarthritis
    Joanna E M Sale
    Sunnybrook and Women s College Health Sciences Centre, 76 Grenville Street, Rm 812B, Toronto, Ontario, Canada M5S 1B2
    Arthritis Rheum 55:272-8. 2006
    ..To explore the experience of adherence to pain medication in older adults with osteoarthritis (OA)...
  76. ncbi The anti-allodynic effects of amitriptyline, gabapentin, and lidocaine in a rat model of neuropathic pain
    S Abdi
    Department of Anesthesiology and Critical Care, The Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    Anesth Analg 87:1360-6. 1998
    ..Finally, the site of action of LDC seems to be primarily in the periphery, and that of GBP is exclusively central, whereas that of AMI seems to have both peripheral and central components...
  77. pmc HC-030031, a TRPA1 selective antagonist, attenuates inflammatory- and neuropathy-induced mechanical hypersensitivity
    Samer R Eid
    Department of Pain Research, Neuroscience Drug Discovery, Merck Research Laboratories, West Point, Philadelphia, USA
    Mol Pain 4:48. 2008
    ..The current study was designed to further explore the therapeutic potential of pharmacological TRPA1 antagonism to treat inflammatory and neuropathic pain...
  78. ncbi [How neuropathic is sciatica? The mixed pain concept]
    R Baron
    Klinik fur Neurologie, Universitatsklinikum Schleswig Holstein, Campus Kiel
    Orthopade 33:568-75. 2004
    ..Therefore, the combination of these analgesic compounds with NSAID could be useful in patients with sciatic pain who do not respond to NSAID...
  79. pmc Effect of resiniferatoxin on the noxious heat threshold temperature in the rat: a novel heat allodynia model sensitive to analgesics
    Róbert Almási
    Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, Neuropharmacology Research Group of the Hungarian Academy of Sciences, University of Pecs, Szigeti u 12, H 7624 Pecs, Hungary
    Br J Pharmacol 139:49-58. 2003
    ..6+/-0.5 vs 45.2+/-0.4 degrees C). 6. In conclusion, the RTX-induced drop of heat threshold measured by the ITHP is a novel heat allodynia model exhibiting a high sensitivity to analgesics.
  80. ncbi Antinociceptive effects of interleukin-4, -10, and -13 on the writhing response in mice and zymosan-induced knee joint incapacitation in rats
    Mariana L Vale
    Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceara, Fortaleza, Ceara, Brazil
    J Pharmacol Exp Ther 304:102-8. 2003
    ..This analgesic effect could be related to a peripheral mechanism, probably via the inhibition of the release of the pro-inflammatory cytokines TNF-alpha and IL-1beta by resident peritoneal macrophages...
  81. pmc Role of voltage-gated calcium channels in ascending pain pathways
    Gerald W Zamponi
    Department of Physiology and Biophysics, Hotchkiss Brain Institute, University of Calgary, 3330 Hospital Drive NW, Calgary, Canada T2N 4N1
    Brain Res Rev 60:84-9. 2009
    ..Here, we provide a brief overview of recent advances in this area, as presented at the Spring Pain Research conference (Grand Cayman, 2008)...
  82. ncbi Symptoms modifying effect of avocado/soybean unsaponifiables (ASU) in knee osteoarthritis. A double blind, prospective, placebo-controlled study
    T Appelboom
    Department of Rheumatology, Erasmus University Hospital of Brussels, Belgium
    Scand J Rheumatol 30:242-7. 2001
    ..The primary endpoint was NSAIDs and analgesics intake between D30 and D90. RESULTS: All efficacy parameters were significantly improved (p<0...
  83. ncbi A systematic review of intravenous ketamine for postoperative analgesia
    Kevin Laskowski
    Department of Anesthesiology, Perioperative Medicine and Pain Management, College of Medicine, University of Saskatchewan, Royal University Hospital, 103 Hospital Drive, Saskatoon, SK S7N 0W8, Canada
    Can J Anaesth 58:911-23. 2011
    ....
  84. ncbi Gabapentin for neuropathic cancer pain: a randomized controlled trial from the Gabapentin Cancer Pain Study Group
    Augusto Caraceni
    Rehabilitation and Palliative Care Unit, National Cancer Institute of Milan, Via Venezian 1, 20133 Milan, Italy
    J Clin Oncol 22:2909-17. 2004
    ..To determine the analgesic effect of the addition of gabapentin to opioids in the management of neuropathic cancer pain...
  85. ncbi Herbal therapy is associated with the risk of CKD in adults not using analgesics in Taiwan
    Jinn Yuh Guh
    Department of Internal Medicine, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    Am J Kidney Dis 49:626-33. 2007
    ..Several cases of Chinese herb nephropathy were reported in Taiwan. Therefore, we studied the association between herbal therapy and chronic kidney disease (CKD) in Taiwan...
  86. ncbi (-)-Linalool produces antinociception in two experimental models of pain
    Alessandra T Peana
    Dipartimento di Scienze del Farmaco, Universita degli Studi di Sassari, Via Muroni 23 A, 07100 Sassari, Italy
    Eur J Pharmacol 460:37-41. 2003
    ..Finally, the activation of opioidergic and cholinergic systems appears to play a crucial role in (-)-linalool-induced antinociception...
  87. ncbi Chronic daily headache in Chinese elderly: prevalence, risk factors, and biannual follow-up
    S J Wang
    Neurological Institute, Veterans General Hospital Taipei, and Department of Neurology, Taiwan
    Neurology 54:314-9. 2000
    ..To investigate the prevalence, risk factors, and prognosis of chronic daily headache (CDH) in a population of elderly Chinese subjects...
  88. ncbi The efficacy and safety of pregabalin in the treatment of neuropathic pain associated with chronic lumbosacral radiculopathy
    Ralf Baron
    Division of Neurological Pain Research and Therapy, Department of Neurology, Christian Albrechts University, Kiel, Germany
    Pain 150:420-7. 2010
    ..Considering the results of all phases of the study, it is difficult to draw definitive conclusions from it, suggesting a need for further work to understand the clinical potential of pregabalin treatment for lumbosacral radiculopathy...
  89. ncbi Antinociceptive action of amlodipine blocking N-type Ca2+ channels at the primary afferent neurons in mice
    M Murakami
    Department of Molecular Pharmacology, Tohoku University School of Medicine, Sendai, Japan
    Eur J Pharmacol 419:175-81. 2001
    ..Furthermore, it is suggested that some N-type Ca2+ channel blockers might have therapeutic potential as analgesics when applied directly into the subarachnoidal space.
  90. ncbi Bioassay-guided evaluation of antioxidant and antinociceptive activities of carvacrol
    Adriana G Guimarães
    Department of Physiology, Federal University of Sergipe DFS UFS, Sao Cristovao, SE, Brazil
    Basic Clin Pharmacol Toxicol 107:949-57. 2010
    ..Together, these results indicate that the properties of CARV should be more thoroughly examined in order to achieve newer tools for management and/or treatment of painful conditions, including those related to pro-oxidant states...
  91. ncbi Antinociceptive and hypothermic evaluation of the leaf essential oil and isolated terpenoids from Eugenia uniflora L. (Brazilian Pitanga)
    Ana Carolina L Amorim
    Instituto de Quimica, Universidade Federal do Rio de Janeiro, Centro de Tecnologia, Bloco A, Sala 626 A, Cidade Universitaria, Ilha do Fundao, 21945 970 Rio de Janeiro, RJ, Brazil
    Phytomedicine 16:923-8. 2009
    ..These findings provided additional pharmacological information and may contribute for the use of Brazilian cherry tree as a phytomedicine...
  92. ncbi Voltage gated calcium channels as targets for analgesics
    Emmanuel Bourinet
    Departement de Physiologie, Institut de Génomique Fonctionnelle CNRS UMR5203, INSERM U661, Universités Montpellier I and II, 141 rue de la Cardonille, 34094 Montpellier Cedex 5, France
    Curr Top Med Chem 5:539-46. 2005
    ..Therefore, the discovery of new analgesics is needed, especially to treat the proportion of painful patients poorly improved by available analgesics...
  93. pmc Placebo conditioning and placebo analgesia modulate a common brain network during pain anticipation and perception
    Alison Watson
    Human Pain Research Group, University of Manchester Rheumatic Diseases Centre, Hope Hospital, Salford M6 8HD, UK
    Pain 145:24-30. 2009
    ..Our results suggest that the main effect of placebo arises from the reduction of anticipation of pain during placebo conditioning that is subsequently maintained during placebo analgesia...
  94. ncbi Curcumin attenuates thermal hyperalgesia in a diabetic mouse model of neuropathic pain
    Sameer Sharma
    Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160014, India
    Eur J Pharmacol 536:256-61. 2006
    ..These results indicate an antinociceptive activity of curcumin possibly through its inhibitory action on NO and TNF-alpha release and point towards its potential to attenuate diabetic neuropathic pain...
  95. pmc A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat
    Michael F Jarvis
    Neuroscience Research, Abbott Laboratories, Abbott Park, IL 60064, USA
    Proc Natl Acad Sci U S A 104:8520-5. 2007
    ..These data demonstrate that acute and selective pharmacological blockade of Na(v)1.8 sodium channels in vivo produces significant antinociception in animal models of neuropathic and inflammatory pain...
  96. ncbi Effect of systemic and intrathecal gabapentin on allodynia in a new rat model of postherpetic neuralgia
    Shao Rui Chen
    Department of Anesthesiology, Pennsylvania State University College of Medicine, The Milton S Hershey Medical Center, Hershey, PA 17033, USA
    Brain Res 1042:108-13. 2005
    ..These data provide complementary new information that gabapentin administered systemically and spinally can effectively relieve tactile allodynia in this animal model of postherpetic neuralgia...
  97. pmc Neuropathic pain: a practical guide for the clinician
    Ian Gilron
    Department of Anesthesiology, Queen s University and Kingston General Hospital, Kingston, Ont
    CMAJ 175:265-75. 2006
    ..nerve disorders, is especially problematic because of its severity, chronicity and resistance to simple analgesics. The condition affects 2%-3% of the population, is costly to the health care system and is personally ..
  98. ncbi Intrathecal minocycline attenuates peripheral inflammation-induced hyperalgesia by inhibiting p38 MAPK in spinal microglia
    Xiao Ying Hua
    Department of Anaesthesiology, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0818, USA
    Eur J Neurosci 22:2431-40. 2005
    ....
  99. ncbi Impact of postherpetic neuralgia and painful diabetic peripheral neuropathy on health care costs
    Robert H Dworkin
    Departments of Anesthesiology and Neurology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    J Pain 11:360-8. 2010
    ..Total excess health care costs associated with painful DPN were substantially greater than those associated with PHN, which might reflect the great medical comorbidity associated with DPN...
  100. ncbi Sensory neuron voltage-gated sodium channels as analgesic drug targets
    Aliakmal Momin
    Molecular Nociception, Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, United Kingdom
    Curr Opin Neurobiol 18:383-8. 2008
    ..These observations provide a rationale for the development of new analgesics without the side effect profile of broad spectrum sodium channel blockers.
  101. ncbi Gender differences in placebo analgesia: event-related potentials and emotional modulation
    Per M Aslaksen
    Department of Psychology, University of Tromsø, 9037 Tromsø, Norway
    Psychosom Med 73:193-9. 2011
    ..Several experimental and clinical studies have shown that males report lower pain compared with females. There are, however, few reports of gender differences in placebo analgesia...

Research Grants79

  1. SUPPORT CONTRACT FOR THE NTP INTERAGENCY CENTER/VALIDATION OF ALT METHODS
    David Allen; Fiscal Year: 2011
    ..These included: [unreadable] The routine use of topical anesthetics, systemic analgesics, and humane endpoints to avoid and minimize pain and distress during in vivo ocular irritation testing...
  2. SUPPORT CONTRACT FOR THE NTP INTERAGENCY CENTER/VALIDATION OF ALT METHODS
    David Allen; Fiscal Year: 2012
    ..These included: [unreadable] The routine use of topical anesthetics, systemic analgesics, and humane endpoints to avoid and minimize pain and distress during in vivo ocular irritation testing...
  3. SUPPORT CONTRACT FOR THE NTP INTERAGENCY CENTER/VALIDATION OF ALT METHODS
    David Allen; Fiscal Year: 2009
    ..In addition, a comprehensive review of the use of topical anesthetics and systemic analgesics for reducing pain and distress will be conducted to determine their applicability in ocular testing...
  4. Abdominal Symptom Phenotypes: Pathways to New Biomarkers
    Robert Shulman; Fiscal Year: 2010
    ..Therapies are typically prescribed to relieve particular symptoms (drugs such as antispasmodics, analgesics or antidepressants for pain, laxatives, antidiarrheals) or change lifestyle features (e.g...
  5. Improving pain and function in hip fracture
    R Sean Morrison; Fiscal Year: 2013
    ..Physicians are reluctant to prescribe opioid analgesics to geriatric patients for fear of precipitating side effects (e.g...
  6. 18F-beta-Endorphin Imaging: Translational Study of an Opioid Peptide Radiotracer
    BRIAN contact REED; Fiscal Year: 2010
    ..agonist at 5-opioid receptors (MOP-r), the target of addictive opioids such as heroin and prescription opioid analgesics such as oxycodone and morphine...
  7. Epigenetic Modifications of BDNF and trkB Genes Underlie Pain Plasticity
    John David Sweatt; Fiscal Year: 2013
    ..such as cancer and HIV, who suffer from treatment-related pain that cannot be controlled with conventional analgesics. Treatment-related pain affects approximately 50% of these patients, depending on drug and dosing regimen, which ..
  8. Exploiting toxins to probe sensory signaling
    David Julius; Fiscal Year: 2012
    ..Notable examples include the use of natural analgesics, such as morphine (from the opium poppy) and salicylate (from willow bark) to discover opioid receptors and ..
  9. Neuron-specific block of T-type calcium channels
    Edward Perez-Reyes; Fiscal Year: 2012
    ..Therefore, the development of novel analgesics without abuse potential and side effects would have significant impact on the treatment of pain...
  10. PTHrP Modulation of TRPV1 in Pain Associated with Breast Cancer Bone Metastasis
    AARON DAVID MICKLE; Fiscal Year: 2013
    ..microenvironment and the adjacent sensory nerve fibers is necessary for the development of highly efficacious analgesics for chronic bone cancer pain...
  11. P450 Epoxygenase Mechanisms of Opioid Analgesia
    LINDSAY HOUGH; Fiscal Year: 2013
    ..This proposal will uncover new biochemical mechanisms for pain relief, and test a new group of chemicals for pain-relieving properties. This research could lead to the development of new, non-addicting pain relievers. ..
  12. Control of Nociception in the Spinal Cord
    Sukhbir S Mokha; Fiscal Year: 2013
    ..KOR agonists will be effective analgesics during the reproductive years in women whereas ORL1 agonists will be more effective in postmenopausal women...
  13. Impact CYP2D6 Phenotype on Response to Methamphetamine in Humans
    Alison Oliveto; Fiscal Year: 2013
    ..demonstrating a greater risk for and severity of dependence on drugs such as nicotine and certain opioid analgesics than poor metabolizers (PMs)...
  14. Development of Estrogen Receptor B Selective Receptor Agonists to Treat Neuropath
    ETHAN SAMUEL BURSTEIN; Fiscal Year: 2012
    ....
  15. Lipid kinase regulation of pain signaling and sensitization
    Mark J Zylka; Fiscal Year: 2013
    PROJECT SUMMARY New approaches for treating chronic pain are needed, particularly since existing analgesics have serious side effects and are not always effective at treating inflammatory pain and neuropathic pain-the two most common ..
  16. Central Mechanisms of Orofacial Pain
    Jianren Mao; Fiscal Year: 2012
    ..of treating orofacial pain with non-steroidal anti-inflammatory drugs, tricyclic antidepressants, and opioid analgesics is often limited by these drugs'side effects and, in some cases, unwanted long-term consequences...
  17. Lipidomic and Transcriptome Signatures in Aspirin-Exacerbated Respiratory Disease
    Joshua A Boyce; Fiscal Year: 2010
    ..in every ten adults with asthma develops life-threatening attacks of asthma when they ingest aspirin or similar analgesics. These individuals suffer from debilitating sinus disease and severe asthma...
  18. Characteristics and mechanisms of pain in sickle cell disease
    DONALD SIMONE; Fiscal Year: 2013
    ..If our hypotheses prove to be true, our results will provide an understanding that will facilitate treating pain in SCD and in developing novel and more effective analgesics.
  19. Role of peroxynitrite in morphine hyperalgesia and tolerance
    Daniela Salvemini; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Opiates like morphine sulfate are the most effective analgesics for treating acute and chronic severe pain, but their use is limited by development of tolerance and hypersensitivity to innocuous and ..
  20. Immune and Gilia Regulation of Pain &Analgesic Actions
    Linda Watkins; Fiscal Year: 2012
    ..Pain facilitation via neuron-to-glia signaling;NIDA R01 (Watkins PI;3/05-12/09;DA017670);(d) Opioid analgesics: modulation...
  21. Novel Analgesics from Australian Funnel-Web Spider Venom
    MICHAEL NATHAN NITABACH; Fiscal Year: 2010
    ..This secondary screen is essential for excluding from future in vivo studies of candidate analgesics those atracotoxins that are inactive against ion channels in their native state in the nociceptor plasma ..
  22. Monoacylglycerol Lipase Inhibitors for Treating Opioid Use Disorders
    Aron H Lichtman; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Opioid addiction from the chronic use of prescription analgesics and illicit agents represents a major unmet public health crisis...
  23. Opioid selection and the risk of serious infections in older adults
    Carlos G Grijalva; Fiscal Year: 2013
    ..A number of opioid analgesics are currently available, but not all have the same immunosuppressive properties...
  24. Endocannabinoid signaling in a model of cancer pain
    Virginia S Seybold; Fiscal Year: 2013
    ..Derivatives of Cannabis sativa (cannabinoids) are potent analgesics, and endogenous cannabinoids share this property...
  25. Tetrahydrobioperin acts as a pain signaling molecule
    Yessenia M Ibarra; Fiscal Year: 2012
    ..Identifying the actions of BH4 in the cell bodies of sensory neurons could lead to potential molecular targets for analgesics to relieve symptoms of chronic pain while eliminating side effects.
  26. PERIPHERAL NOCICEPTORS IN PERSISTENT PAIN
    PATRICK WILLIAM MANTYH; Fiscal Year: 2012
    ..Currently, there is a limited repertoire of analgesics to control skeletal pain (primarily opiates and NSAIDs) and both have significant, unwanted CNS and/or bone ..
  27. Local anesthetic receptor in peripheral Na+ channels
    GING K WANG; Fiscal Year: 2013
    ..Recent evidence suggests that pain therapeutics such as duloxetine may act as analgesics to silence persistent late Na+ currents via a duloxetine/local anesthetic shared receptor...
  28. Mu-Opioid Effects on the Central Mechanisms that Control Breathing
    Edward J Zuperku; Fiscal Year: 2013
    ..and synthetic 5-opioid receptor (5OR) analogs such as fentanyl and remifentanil (remi) are highly effective analgesics used to treat severe acute and chronic pain...
  29. Potent Analgesic Conopeptides for Treatment of Chronic Spinal Cord Injury Pain
    Jacqueline Sagen; Fiscal Year: 2012
    ..Our laboratory has been evaluating traditional and non-traditional analgesics alone and in combinations for their ability to reduce neuropathic pain symptoms in a spinal clip compression ..
  30. Blood-to-CNS Drug Uptake in Pain
    THOMAS PAUL DAVIS; Fiscal Year: 2013
    ..Our hypothesis is that changes in transport of commonly prescribed opioid analgesics and novel therapeutic opioid peptides will occur due to alterations in the functional expression of putative ..
  31. Design, Synthesis and Evaluation of Novel Isoform-Selective Sodium Channel Inhibi
    JOHN VINCENT MULCAHY; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Side effects associated with opioid analgesics, such as nausea, drowsiness, respiratory depression, and potential for addiction, are motivating the design and development of new therapies for acute, ..
  32. Strategies for Prescribing Analgesics Comparative Effectiveness (SPACE) Trial
    ERIN ELIZABETH KREBS; Fiscal Year: 2013
    ..Although evidence supports the ability of opioid analgesics to produce short-term reductions in pain intensity, long-term trials evaluating opioid effectiveness are not ..
  33. Effectiveness of Mandatory Prescription Drug Monitoring
    Guohua Li; Fiscal Year: 2012
    ..that the majority of unintentional overdose morbidity and mortality are attributable to nonmedical use of opioid analgesics and benzodiazepines obtained from diversion and 'doctor shopping...
  34. Aspirin, PPAR and EAE
    Kalipada Pahan; Fiscal Year: 2013
    ..Our preliminary results show that it is possible with aspirin, acetylsalicylic acid, one f the most widely-used analgesics throughout the world...
  35. Analgesic technique on pain and biomarkers during sickle pain crisis
    Gailen D Marshall; Fiscal Year: 2011
    ..and to test the hypothesis that serum biomarkers can be used to predict need for admission, increased need for analgesics, and possibly disease complication rates in SCD...
  36. Tetrahydrobiopterin and pain
    Clifford J Woolf; Fiscal Year: 2012
    ..to explore the molecular mechanisms responsible for pain and identify novel targets for the development of new analgesics. Relevance: Persistent pain is an enormous problem due both to the suffering experienced by patients and the ..
  37. Crystallization and structure determination of the mu-opioid receptor
    Roger K Sunahara; Fiscal Year: 2012
    ..While effective attenuators of pain, analgesics that work on [unreadable]OR have various adverse and sometimes fatal side-effects including nausea, respiratory ..
  38. Developing Small MIF Inhibitors for Rheumatoid Arthritis
    Christian Grant; Fiscal Year: 2013
    ..Current therapeutic strategies include steroids and analgesics for the pain, while preventative strategies include disease modifying anti-rheumatic drugs (DMARDs)...
  39. Naloxone prescription for Opioid Safety Evaluation (NOSE)
    Phillip O Coffin; Fiscal Year: 2013
    ..S. This dramatic shift has been attributed to opioid analgesic overdose;deaths from opioid analgesics have exceeded the combined overdose deaths from heroin and cocaine since 2003...
  40. Targeting Leukemia Stem Cells with Dietary Selenium
    KUMBLE SANDEEP PRABHU; Fiscal Year: 2013
    ..serum Se levels in leukemia patients as well as higher incidences of adult leukemia in individuals consuming non-aspirin analgesics, our long- term goal is to understand if Se supplementation of leukemia patients would be beneficial.
  41. Chemokines, TRP Channels and Cancer Pain
    Durga Prasanna Mohapatra; Fiscal Year: 2013
    ..suffering from prostate cancer bone metastasis, so as to improve the quality of their life, currently available analgesics often do not provide adequate pain relief, due to lack of specificity and unwanted side-effects...
  42. Medications and the Risk of Sudden Cardiac Death
    Wayne A Ray; Fiscal Year: 2013
    ..for chronic pain, the risk of sudden cardiac death in methadone users is greater than that for comparable opioid analgesics. 3...
  43. Intra-pulmonary aerosol delivery for intubated pediatric patients
    AMIR A NAQWI; Fiscal Year: 2013
    ..delivery of agents such as, antibiotics (for treatment of pneumonia and sepsis), as well as glucose, steroids, analgesics, and sedatives...
  44. Prostaglandin E2 Signaling in Growth and Pains of Endometriosis
    Joe A Arosh; Fiscal Year: 2012
    ..Inhibition of PGE2 biosynthesis using NSAIDs and COX-2 inhibitors has emerged as the main class analgesics. However, clinical use of NSAIDs produces unwanted side effects such as gastric erosion, ulceration, and ..
  45. Analgesics targeting truncated 6transmembrane exon 11 variants of MOR-1 (6TM-E11)
    Susruta Majumdar; Fiscal Year: 2013
    ..I propose to use it as a lead compound to design a library of opioid analgesics. In spite of its favorable pharmacology, its selectivity for the new target over the traditional ones is only ..
  46. Role of the Supraspinal Opioidergic Circuit in Prefrontal TMS-Induced Analgesia
    JOSEPH JEFFREY TAYLOR; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Opioid analgesics that are prescribed for pain management pose a significant health risk in terms of abuse potential and dose-dependent side effects...
  47. Acetaminophen Pharmacogenetics
    Michael H Court; Fiscal Year: 2010
    ....
  48. Transcranial Direct Current Stimulation in the Management of Post-operative Pain
    Jeffrey J Borckardt; Fiscal Year: 2013
    ..Additionally, systemic opioid analgesics have associated side-effects that can lead to post-operative complications including but not limited to mental-..
  49. Clinical Development of 4-Cl-KYN to Treat Pain
    RALPH SNODGRASS; Fiscal Year: 2010
    ..models, and have fewer side effects than classic NMDA receptor antagonists, making them a safer alternative as analgesics. 7-Cl-KYNA prevents excitotoxic and ischemic neuronal damage but like most GlyB antagonists does not cross the ..
  50. Mu opioid agonists with reduced side effects for the treatment of pain
    Chad E Groer; Fiscal Year: 2011
    ..The proposed research is designed to develop a novel class of opioid analgesics that produce less tolerance and may potentially reduce opiate-associated side effects...
  51. Risk Factors for Hearing Loss
    Gary C Curhan; Fiscal Year: 2013
    ..In addition to noise, factors potentially associated with risk of hearing loss include analgesics, vitamins, alcohol, menopausal status and postmenopausal hormone use...
  52. Unique Opioid Analgesics With No Addiction Liability or Dysphoria
    John A Lawson; Fiscal Year: 2011
    ..It is a second-generation analog of a seminal but off-patent compound, PPL-101, discovered in 1979. Both analgesics show low addiction liability and dysphoria in animals...
  53. Development of NMUR2 Antagonists as Novel Analgesics
    NEIL CUTSHALL; Fiscal Year: 2013
    ..These findings make NMUR2 an attractive drug target and suggest that NMUR2 antagonists may be useful analgesics with potentially limited side effects...
  54. NEUROPEPTIDERGIC INHIBITION OF SPINAL PAIN TRANSMISSION
    Bradley K Taylor; Fiscal Year: 2013
    ..Such studies are critical not only to determine whether NPY is a natural long-lasting analgesic that reduces the duration of pain, but also to harness its therapeutic potential towards the development of new analgesic drugs. ..
  55. Predictors of Opioid Analgesic Responses and Common Endogenous Opioid Mechanisms
    John W Burns; Fiscal Year: 2013
    ..Use of opioid analgesics for management of nonmalignant chronic pain has increased dramatically, yet is fraught with controversy due to ..
  56. Interactions Between the Brain Reward and Pain Systems.
    Conan Kornetsky; Fiscal Year: 2010
    ..It is possible that such findings will contribute to the development of better analgesics that are less addicting.
  57. Persistent Pain and Opioid Mechanisms in the Rostroventral Medial Medulla
    MARLENE CANO; Fiscal Year: 2011
    ..to adaptive changes in the RVM that change the balance of these pathways and that increase the potency of opioid analgesics. Investigation of the mechanisms by which 5 opioid receptor (MOPr) agonists suppress acute nociception and ..
  58. Analgesics Targeting TRPA1 for Treatment of Chronic Pain
    JEFF MARK HERZ; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Title: Analgesics Targeting TRPA1 for Treatment of Chronic Pain Abstract An effective treatment for chronic pain that is devoid of both addictive potential and abuse liability is a major unmet need in ..
  59. Epigenetic Mechanisms of Neuropathic Pain
    Hui Lin Pan; Fiscal Year: 2013
    ..Neuropathic pain remains a major clinical problem and therapeutic challenge because existing analgesics are often ineffective and can cause serious side effects...
  60. Mixed NOP/mu compounds and the involvement of their receptors in analgesia.
    LAWRENCE R TOLL; Fiscal Year: 2013
    ..of the mechanism by which NOP-active compounds mediate an antinociceptive or anti-allodynic response, and progress selective NOP agonists, and mixed NOP/mu agonists toward clinical use as analgesics with reduced addiction liability.
  61. Central Nervous System Delivery of Opioid Peptides
    JOHN HOEKMAN; Fiscal Year: 2012
    ..Administration of traditional mu-opioid analgesics presents numerous problems, including gastrointestinal side effects, drug-drug interactions with other CNS ..
  62. DEVELOPMENT OF RECEPTOR-SPECIFIC OPIOID PEPTIDE ANALOGS
    Peter W Schiller; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): There is an urgent clinical need for the development of opioid analgesics with novel biological activity profiles that lack the limiting side effects of currently available opiates...
  63. Psychoactive Medications: Associations with Delirium Persistance vs Resolution
    Edward Marcantonio; Fiscal Year: 2009
    ..of psychoactive medications: 1) sedative-hypnotics, 2) antipsychotics, 3) anticholinergics, and 4) opioid analgesics, with delirium persistence over a one-month time period...
  64. GENDER AND SEX HORMONES AND OPIOID ANALGESIA
    Jon Levine; Fiscal Year: 2006
    ..considerable research on gender differences in pain sensitivity, sex differences in pain modulation by opioid analgesics in humans have only recently been examined...
  65. ETHNIC DISPARITY IN THE USE OF JOINT ARTHROPLASTY
    DENNIS ANG; Fiscal Year: 2007
    ..Therapeutic agents that have been investigated include analgesics, non-steroidal anti-inflammatory drugs (NSAIDs), intra-articular hyaluronate preparations, and "novel" drugs...
  66. Acu/Moxa for Peripheral Neuropathy in Pts with HIV
    JOYCE ANASTASI; Fiscal Year: 2007
    ..Treatments prescribed to manage the pain associated with DSP, such as nonnarcotic and narcotic analgesics, antidepressants and anticonvulsants, are largely ineffective...
  67. Safety and Efficacy of Patient Controlled Analgesia in the Emergency Department
    Polly Bijur; Fiscal Year: 2009
    ..Inadequate ED pain management has been well documented. Opioid analgesics constitute the standard treatment of acute pain, however there are numerous obstacles to optimal use of opioids ..
  68. Peripheral Nerve Blocks with Multimodal Analgesics
    Brian Williams; Fiscal Year: 2009
    ..Such a block would further advance opioid-sparing analgesia, and aim to reduce patient dependence on opioid analgesics as the primary mechanism of analgesia in the first week(s) after orthopedic surgery...
  69. Herb-Opioid Interactions
    Danny Shen; Fiscal Year: 2003
    ..Johns wort as a "mood enhancer" and natural antidepressant, cancer pain patients receiving opioid analgesics may well turn to this herbal preparation for relief of depressive symptoms...
  70. Methods for the Development of Arrestin2 Inhibitors.
    Spiro Pavlopoulos; Fiscal Year: 2010
    ..for many of the most notorious prescription pharmaceuticals that lead to addiction such as several of the opiod analgesics (e.g. Vicodin, Oxycontin) in addition to illicit drugs (e.g. cannabis)...
  71. Novel drug combinations for the management of pain
    KENNETH NARDUCY; Fiscal Year: 2007
    ..However, combinations of analgesics with different mechanisms of action could enhance analgesic efficacy (synergy) while reducing the dose-dependent ..
  72. Morphine in Mammals
    MEINHART ZENK; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Morphine, one of the strongest analgesics known, is produced by and commercially isolated from the opium poppy plant...
  73. Race in Physician Decision to Prescribe Opioid Analgesia
    JOSHUA SARVER; Fiscal Year: 2002
    ..provided by applicant) Several studies have shown that racial and ethnic minorities are less likely to receive analgesics. This study presents a theoretical framework for understanding these differences...
  74. Bivalent ligands as molecular probes for CB1/OX1 receptor heterodimers
    Yanan Zhang; Fiscal Year: 2010
    ..the work with u-opioid (MOP) agonist/d-opioid (DOP) antagonist bivalent ligands were shown to be potent analgesics after systemic administration, but did not produce the tolerance or dependence seen with traditional monovalent ..
  75. Non-Peptide Somatostatin Agonist Analgesics
    Susan Carlton; Fiscal Year: 2007
    ..develop non-peptide SSTR agonists known as NISAs (Non-peptide Imidazolidinedione Somatostatin Agonists) as novel analgesics. Phase I studies were completed using the potent and highly SSTR2 selective NISA, SCR007...
  76. Regulated Osteochondrogenesis of Human Mesenchymal Stem Cells Using Gene Delivery
    Antonios Mikos; Fiscal Year: 2009
    ..Although there are numerous analgesics, therapeutic strategies and surgical procedures developed to address this health concern, most of the therapies ..
  77. Development of Opioid Receptor Models for Rational Design of Bifunctional Ligands
    JUDITH HOBRATH; Fiscal Year: 2009
    ..The use of these mu agonist opioid analgesics is severely restricted by a number of serious side effects such as development of tolerance and dependence and ..
  78. Hyperalgesia in Methadone Patients: Can it be Treated?
    Margaret Compton; Fiscal Year: 2007
    ..tolerance, in addition to the contextual prohibitions associated with providing known opioid addicts with opioid analgesics, makes them a population uniquely vulnerable to the under treatment of pain...
  79. Analgesic Use and Kidney Cancer
    Eunyoung Cho; Fiscal Year: 2009
    ..S. and worldwide. Nevertheless, the etiology of this malignancy is largely unexplored. Analgesics are a diverse group of drugs used to relieve pain, including acetaminophen and non-steroidal anti- inflammatory ..