vasodilator agents

Summary

Summary: Drugs used to cause dilation of the blood vessels.

Top Publications

  1. ncbi Prognostic impact of coronary vasodilator dysfunction on adverse long-term outcome of coronary heart disease
    V Schachinger
    Department of Internal Medicine IV, Division of Cardiology, J W Goethe University, Frankfurt, Germany
    Circulation 101:1899-906. 2000
  2. ncbi Endothelial dysfunction, oxidative stress, and risk of cardiovascular events in patients with coronary artery disease
    T Heitzer
    Universitatsklinikum Hamburg Eppendorf, Klinik und Poliklinik für Innere Medizin, Abteilung Kardiologie, Hamburg, Germany
    Circulation 104:2673-8. 2001
  3. pmc Considerations when measuring myocardial perfusion reserve by cardiovascular magnetic resonance using regadenoson
    Nicole M Bhave
    Departments of Medicine and Radiology, University of Chicago, Cardiac Imaging Center, Chicago, IL 60637, USA
    J Cardiovasc Magn Reson 14:89. 2012
  4. ncbi Inhaled iloprost for severe pulmonary hypertension
    Horst Olschewski
    Department of Internal Medicine II, University Clinic, Giessen, Germany
    N Engl J Med 347:322-9. 2002
  5. ncbi Sustained improvement with iloprost in a COPD patient with severe pulmonary hypertension
    Matthew J Hegewald
    Division of Pulmonary and Critical Care Medicine Intermountain Medical Center, University of Utah School of Medicine, Salt Lake City, UT 84157 7000, USA
    Chest 135:536-7. 2009
  6. ncbi A randomised, controlled trial of bosentan in severe COPD
    D Stolz
    Clinic of Pulmonary Medicine and Respiratory Cell Research, University Hospital Basel, Petersgraben 4, CH 4031 Basel, Switzerland
    Eur Respir J 32:619-28. 2008
  7. pmc The effect of obesity on regadenoson-induced myocardial hyperemia: a quantitative magnetic resonance imaging study
    Edward V R DiBella
    UCAIR, Department of Radiology, University of Utah, Salt Lake City, UT, USA
    Int J Cardiovasc Imaging 28:1435-44. 2012
  8. ncbi Periadventitial fat releases a vascular relaxing factor
    Matthias Löhn
    HELIOS Klinikum Berlin, Franz Volhard Clinic and Max Delbrück Center for Molecular Medicine, Medical Faculty of the Charite, Humboldt University of Berlin, Germany
    FASEB J 16:1057-63. 2002
  9. ncbi Adenosine versus regadenoson comparative evaluation in myocardial perfusion imaging: results of the ADVANCE phase 3 multicenter international trial
    Ami E Iskandrian
    University of Alabama at Birmingham, Birmingham, AL 35294 0006, USA
    J Nucl Cardiol 14:645-58. 2007
  10. ncbi Regular aerobic exercise prevents and restores age-related declines in endothelium-dependent vasodilation in healthy men
    C A DeSouza
    Human Cardiovascular Research Laboratory, Center for Physical Activity, Disease Prevention, and Aging, Department of Kinesiology and Applied Physiology, University of Colorado, Boulder 80309, USA
    Circulation 102:1351-7. 2000

Detail Information

Publications301 found, 100 shown here

  1. ncbi Prognostic impact of coronary vasodilator dysfunction on adverse long-term outcome of coronary heart disease
    V Schachinger
    Department of Internal Medicine IV, Division of Cardiology, J W Goethe University, Frankfurt, Germany
    Circulation 101:1899-906. 2000
    ..Therefore, we prospectively investigated whether coronary endothelial dysfunction predicts disease progression and cardiovascular event rates...
  2. ncbi Endothelial dysfunction, oxidative stress, and risk of cardiovascular events in patients with coronary artery disease
    T Heitzer
    Universitatsklinikum Hamburg Eppendorf, Klinik und Poliklinik für Innere Medizin, Abteilung Kardiologie, Hamburg, Germany
    Circulation 104:2673-8. 2001
    ..This study was designed to determine whether endothelial dysfunction and vascular oxidative stress have prognostic impact on cardiovascular event rates in patients with coronary artery disease...
  3. pmc Considerations when measuring myocardial perfusion reserve by cardiovascular magnetic resonance using regadenoson
    Nicole M Bhave
    Departments of Medicine and Radiology, University of Chicago, Cardiac Imaging Center, Chicago, IL 60637, USA
    J Cardiovasc Magn Reson 14:89. 2012
    ..We sought to determine the optimal regadenoson CMR protocol for quantifying myocardial perfusion reserve index (MPRi) - more specifically, whether regadenoson stress imaging should be performed before or after rest imaging...
  4. ncbi Inhaled iloprost for severe pulmonary hypertension
    Horst Olschewski
    Department of Internal Medicine II, University Clinic, Giessen, Germany
    N Engl J Med 347:322-9. 2002
    ..Uncontrolled studies suggested that aerosolized iloprost, a stable analogue of prostacyclin, causes selective pulmonary vasodilatation and improves hemodynamics and exercise capacity in patients with pulmonary hypertension...
  5. ncbi Sustained improvement with iloprost in a COPD patient with severe pulmonary hypertension
    Matthew J Hegewald
    Division of Pulmonary and Critical Care Medicine Intermountain Medical Center, University of Utah School of Medicine, Salt Lake City, UT 84157 7000, USA
    Chest 135:536-7. 2009
    ..The improvement was sustained for 2 years. Severe PH in patients with COPD needs to be recognized and novel treatment approaches considered...
  6. ncbi A randomised, controlled trial of bosentan in severe COPD
    D Stolz
    Clinic of Pulmonary Medicine and Respiratory Cell Research, University Hospital Basel, Petersgraben 4, CH 4031 Basel, Switzerland
    Eur Respir J 32:619-28. 2008
    ....
  7. pmc The effect of obesity on regadenoson-induced myocardial hyperemia: a quantitative magnetic resonance imaging study
    Edward V R DiBella
    UCAIR, Department of Radiology, University of Utah, Salt Lake City, UT, USA
    Int J Cardiovasc Imaging 28:1435-44. 2012
    ..Fixed dose regadenoson and weight adjusted adenosine produce similar measures of MPR in patients with a wide range of body sizes. Regadenoson is a potentially useful vasodilator for stress MRI studies...
  8. ncbi Periadventitial fat releases a vascular relaxing factor
    Matthias Löhn
    HELIOS Klinikum Berlin, Franz Volhard Clinic and Max Delbrück Center for Molecular Medicine, Medical Faculty of the Charite, Humboldt University of Berlin, Germany
    FASEB J 16:1057-63. 2002
    ..We suggest that perivascular adventitial adipose tissue releases a transferable adventitium-derived relaxing factor that acts by tyrosine kinase-dependent activation of K+ channels in vascular smooth muscle cells...
  9. ncbi Adenosine versus regadenoson comparative evaluation in myocardial perfusion imaging: results of the ADVANCE phase 3 multicenter international trial
    Ami E Iskandrian
    University of Alabama at Birmingham, Birmingham, AL 35294 0006, USA
    J Nucl Cardiol 14:645-58. 2007
    ..Earlier phase 1 and 2 studies have shown that regadenoson has desirable features as a stress agent for myocardial perfusion imaging...
  10. ncbi Regular aerobic exercise prevents and restores age-related declines in endothelium-dependent vasodilation in healthy men
    C A DeSouza
    Human Cardiovascular Research Laboratory, Center for Physical Activity, Disease Prevention, and Aging, Department of Kinesiology and Applied Physiology, University of Colorado, Boulder 80309, USA
    Circulation 102:1351-7. 2000
    ..We determined the influence of regular aerobic exercise on the age-related decline in endothelium-dependent vasodilation...
  11. ncbi Prevention and reversal of premature endothelial cell senescence and vasculopathy in obesity-induced diabetes by ebselen
    Sergey V Brodsky
    Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    Circ Res 94:377-84. 2004
    ....
  12. ncbi Prostacyclin therapies for the treatment of pulmonary arterial hypertension
    M Gomberg-Maitland
    Dept of Cardiology, University of Chicago Hospitals, Chicago, IL, USA
    Eur Respir J 31:891-901. 2008
    ..Combination of other targeted therapies with prostanoids appears to be effective and safe. After 25 yrs of continued knowledge, prostanoids remain a mainstay in the treatment of pulmonary arterial hypertension...
  13. ncbi Pulmonary arterial hypertension
    Vallerie V McLaughlin
    University of Michigan Health System, Ann Arbor, MI 48109 0273, USA
    Circulation 114:1417-31. 2006
  14. ncbi Pulmonary hypertension in patients with chronic obstructive pulmonary disease: advances in pathophysiology and management
    Joan Albert Barbera
    Department of Pulmonary Medicine, Hospital Clinic, Universitat de Barcelona, Spain
    Drugs 69:1153-71. 2009
    ..The use of specific PAH therapy in COPD patients with moderate PH is discouraged because of the potential detrimental effect of some of these drugs on gas exchange and there are no data demonstrating their efficacy...
  15. ncbi Enhanced oral bioavailability of puerarin using microemulsion vehicle
    Hongfei Wu
    Department of Pharmaceutics, Anhui University of Traditional Chinese Medicine, Anhui Province Key Laboratory of R and D of Chinese Medicine, Hefei, P R China
    Drug Dev Ind Pharm 35:138-44. 2009
    ..Puerarin microemulsion also showed good stability. These studies showed that microemulsion system of puerarin might be promising vehicles for the peroral delivery of puerarin...
  16. ncbi Ovariectomy increases the formation of prostanoids and modulates their role in acetylcholine-induced relaxation and nitric oxide release in the rat aorta
    Aina Martorell
    Departamento de Fisiologia, Facultad de Medicina, Universidad Autonoma de Madrid, C Arzobispo Morcillo 4, 28029 Madrid, Spain
    Cardiovasc Res 84:300-8. 2009
    ....
  17. ncbi Favorable short-term outcome of transplanted hearts selected from marginal donors by pharmacological stress echocardiography
    Tonino Bombardini
    Institute of Clinical Physiology, National Research Council, Pisa, Italy
    J Am Soc Echocardiogr 24:353-62. 2011
    ..The aim of this study was to establish the feasibility of an approach based on pharmacologic stress echocardiography as a gatekeeper for extended heart donor criteria...
  18. ncbi Addition of inhaled treprostinil to oral therapy for pulmonary arterial hypertension: a randomized controlled clinical trial
    Vallerie V McLaughlin
    University of Michigan Health System, CVC Cardiovascular Medicine, Ann Arbor, Michigan 48109 5853, USA
    J Am Coll Cardiol 55:1915-22. 2010
    ..This study assessed the efficacy and safety of inhaled treprostinil in pulmonary arterial hypertension (PAH) patients receiving therapy with either bosentan or sildenafil...
  19. ncbi Iloprost improves gas exchange and exercise tolerance in patients with pulmonary hypertension and chronic obstructive pulmonary disease
    Tarek A Dernaika
    University of Oklahoma Health Sciences Center, Pulmonary and Critical Care Medicine, Oklahoma City, OK 73104, USA
    Respiration 79:377-82. 2010
    ..Inhaled iloprost has the potential to act preferentially in ventilated regions of the lung, thereby reducing pulmonary hypertension (PH) while alveolar ventilation is still maintained...
  20. ncbi Long-term prophylactic treatment of attacks of vertigo in Menière's disease--comparison of a high with a low dosage of betahistine in an open trial
    Michael Strupp
    Department of Neurology, University of Munich, Munich, Germany
    Acta Otolaryngol 128:520-4. 2008
    ....
  21. pmc The adverse events and hemodynamic effects of adenosine-based cardiac MRI
    Thomas Voigtlander
    Cardiovascular Center Bethanien, Frankfurt Main, Germany
    Korean J Radiol 12:424-30. 2011
    ..We wanted to prospectively assess the adverse events and hemodynamic effects associated with an intravenous adenosine infusion in patients with suspected or known coronary artery disease and who were undergoing cardiac MRI...
  22. pmc CRF2 receptors are highly expressed in the human cardiovascular system and their cognate ligands urocortins 2 and 3 are potent vasodilators
    Katherine E Wiley
    Clinical Pharmacology Unit, School of Clinical Medicine, Centre for Clinical Investigation, University of Cambridge, Box 110, Level 6, Cambridge CB2 2QQ
    Br J Pharmacol 143:508-14. 2004
    ....
  23. ncbi Patients with syndrome X have normal transmural myocardial perfusion and oxygenation: a 3-T cardiovascular magnetic resonance imaging study
    Theodoros D Karamitsos
    Department of Cardiovascular Medicine, Centre for Clinical Magnetic Resonance Research, University of Oxford, Oxford, UK
    Circ Cardiovasc Imaging 5:194-200. 2012
    ....
  24. pmc Trimetazidine, administered at the onset of reperfusion, ameliorates myocardial dysfunction and injury by activation of p38 mitogen-activated protein kinase and Akt signaling
    Mahmood Khan
    Division of Cardiovascular Medicine, Department of Internal Medicine, Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio 43210, USA
    J Pharmacol Exp Ther 333:421-9. 2010
    ..The study emphasizes the importance of administering TMZ before reflow to prevent reperfusion-mediated cardiac injury and dysfunction...
  25. ncbi Impairment of endothelium-dependent ACh-induced relaxation in aorta of diabetic db/db mice--possible dysfunction of receptor and/or receptor-G protein coupling
    Tomohiro Miike
    Research Laboratories, Kyoto Pharmaceutical Industries, Ltd, Kyoto, 604 8444, Japan
    Naunyn Schmiedebergs Arch Pharmacol 377:401-10. 2008
    ..Endothelial dysfunction was not genetic and was considered to be initiated primarily by hyperglycemia, and was improved by anti-diabetic treatment with a PPARgamma agonist...
  26. ncbi Regadenoson, a selective A2A adenosine receptor agonist, causes dose-dependent increases in coronary blood flow velocity in humans
    Hsiao D Lieu
    Portola Pharmaceuticals, South San Francisco, Calif, USA
    J Nucl Cardiol 14:514-20. 2007
    ..This study characterized the dose dependence of regadenoson-induced coronary hyperemia...
  27. ncbi Comparative profile of vasodilation by CVT-3146, a novel A2A receptor agonist, and adenosine in conscious dogs
    Gong Zhao
    CV Therapeutics, Inc, Palo Alto, CA 94304, USA
    J Pharmacol Exp Ther 307:182-9. 2003
    ..Furthermore, CVT-3146 did not cause renal vasoconstriction. These features make CVT-3146 a better candidate for pharmacologic stress testing...
  28. ncbi Assessment of microvascular endothelial function in human skin
    D J Newton
    Peripheral Vascular Diseases Research Unit, University Department of Medicine, Ninewells Hospital and Medical School, Dundee DD1 9SY, Scotland, UK
    Clin Sci (Lond) 101:567-72. 2001
    ....
  29. ncbi Protein kinase C activation increases endothelial nitric oxide release in mesenteric arteries from orchidectomized rats
    Javier Blanco-Rivero
    Departamento de Fisiologia, Facultad de Medicina, Universidad Autonoma de Madrid, C Arzobispo Morcillo 4, 28029 Madrid, Spain
    J Endocrinol 192:189-97. 2007
    ..In addition, PKC seems to modulate eNOS activity only in mesenteric arteries from orchidectomized rats, in which conventional and PKCzeta isoforms are involved in the positive regulation of eNOS...
  30. ncbi Screening of vasorelaxant activity of some medicinal plants used in Oriental medicines
    Ming Hao Yin
    Department of Herbal Resources, Professional Graduate School of Oriental Medicine and Medicinal Resources Research Institute MeRRI, Wonkwang University, Iksan, Jeonbuk 570 749, Republic of Korea
    J Ethnopharmacol 99:113-7. 2005
    ..These results will be useful to further analyze those medicinal plants that contain the vasorelaxant activity in order to identify the active principles...
  31. ncbi Haemodynamic and clinical effects of ularitide in decompensated heart failure
    Veselin Mitrovic
    Kerckhoff Klinik, Bad Nauheim, Germany
    Eur Heart J 27:2823-32. 2006
    ..We assessed the efficacy and safety of ularitide in treating patients with DHF...
  32. ncbi KATP channel activation induces ischemic preconditioning of the endothelium in humans in vivo
    M W Broadhead
    Centre for Clinical Pharmacology, University College London, London, United Kingdom
    Circulation 110:2077-82. 2004
    ..IPC may involve activation of ATP-sensitive potassium channels (K(ATP)). We determined whether modulation of K(ATP) channels occurs in endothelial IPC in humans...
  33. ncbi Wavelet analysis of oscillations in the peripheral blood circulation measured by laser Doppler technique
    A Stefanovska
    Faculty of Electrical Engineering, University of Ljubljana, Slovenia
    IEEE Trans Biomed Eng 46:1230-9. 1999
    ..01 Hz. The study illustrates the potential of laser Doppler flowmetry combined with dynamical systems analysis for studies of both the micro- and macroscopic mechanisms of blood flow regulation in vivo...
  34. ncbi Health care resources and costs for treating peripheral artery disease in a managed care population: results from analysis of administrative claims data
    Jay Margolis
    HealthCore, Inc, Wilmington, DE 19801 1366, USA
    J Manag Care Pharm 11:727-34. 2005
    ....
  35. ncbi Noninvasive assessment of coronary flow velocity and coronary flow velocity reserve in the left anterior descending coronary artery by Doppler echocardiography: comparison with invasive technique
    T Hozumi
    Division of Cardiology, Kobe General Hospital, Japan
    J Am Coll Cardiol 32:1251-9. 1998
    ....
  36. ncbi Brachial flow-mediated vasodilator responses in population-based research: methods, reproducibility and effects of age, gender and baseline diameter
    D M Herrington
    Department of Internal Medicine Cardiology, Wake Forest University School Medicine, Winston Salem, North Carolina 27157 1045, USA
    J Cardiovasc Risk 8:319-28. 2001
    ..Brachial artery ultrasound has been proposed as an inexpensive, accurate way to assess cardiovascular risk in populations. However, analysis and interpretation of these data are not uniform...
  37. ncbi Beneficial effects of intracoronary adenosine as an adjunct to primary angioplasty in acute myocardial infarction
    M Marzilli
    Cardiothoracic Department, University of Pisa Medical School, and CNR Institute of Clinical Physiology, Pisa, Italy
    Circulation 101:2154-9. 2000
    ..In animal models, adenosine limits reperfusion injury, reducing infarct size and improving ventricular function. The aim of this study was to evaluate the safety and feasibility of adenosine adjunct to primary PTCA in AMI...
  38. ncbi Regadenoson: a new myocardial stress agent
    Wael Al Jaroudi
    Department of Medicine, The University of Alabama at Birmingham, USA
    J Am Coll Cardiol 54:1123-30. 2009
    ..This review will summarize the pre-clinical and clinical data on regadenoson, as they specifically relate to its use as a vasodilator stress agent, currently the only approved selective A(2A) agonist...
  39. ncbi Ethosomes - novel vesicular carriers for enhanced delivery: characterization and skin penetration properties
    E Touitou
    Department of Pharmaceutics, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, POB 12065, Jerusalem, Israel
    J Control Release 65:403-18. 2000
    ..Experiments using fluorescent probes and ultracentrifugation showed that the ethosomes had a high entrapment capacity for molecules of various lyophilicities...
  40. ncbi Estimating a minimally important difference in pulmonary arterial hypertension following treatment with sildenafil
    Claire Gilbert
    PGRD, Pfizer Ltd, Sandwich, UK
    Chest 135:137-42. 2009
    ..These analyses were undertaken to help define a minimally important difference (MID) in exercise capacity, measured by the 6-min walk distance (6MWD), and HRQoL, measured by the Short Form-36 (SF-36) questionnaire in patients with PAH...
  41. ncbi High doses of vitamin C reverse Escherichia coli endotoxin-induced hyporeactivity to acetylcholine in the human forearm
    Johannes Pleiner
    Department of Clinical Pharmacology, University of Vienna, Austria
    Circulation 106:1460-4. 2002
    ..Acute inflammation causes endothelial vasodilator dysfunction that may be mediated by oxidative stress...
  42. ncbi Role of NAD(P)H oxidase on vascular alterations in angiotensin II-infused mice
    Agostino Virdis
    CIHR Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Quebec, Canada
    J Hypertens 22:535-42. 2004
    ..Angiotensin (Ang) II stimulates vascular reactive oxygen species generation via NAD(P)H oxidase activation. We investigated whether vascular NAD(P)H oxidase influences structure and function of resistance arteries from Ang II-infused mice...
  43. ncbi Cardiovascular protective effects of nebivolol in Zucker diabetic fatty rats
    Jorge Toblli
    Laboratory of Experimental Medicine, Hospital Aleman, Argentina
    J Hypertens 28:1007-19. 2010
    ..Although effective in reducing blood pressure, therapy with a first-generation [beta]-blocker is currently controversial in metabolic syndrome due to its negative impact on carbohydrate and lipid metabolism...
  44. ncbi Novel short-acting A2A adenosine receptor agonists for coronary vasodilation: inverse relationship between affinity and duration of action of A2A agonists
    Z Gao
    Department of Pharmacological Sciences, CV Therapeutics, Palo Alto, California 94304, USA
    J Pharmacol Exp Ther 298:209-18. 2001
    ..Hence, the low-affinity A2A agonists CVT-3146 and CVT-3033 may prove to be superior to currently available high-affinity agonists as coronary vasodilators during myocardial imaging with radionuclide agents...
  45. ncbi Current concepts in assessment of microvascular endothelial function using laser Doppler imaging and iontophoresis
    Jamie Turner
    University Division of Medicine and Therapeutics, The Institute of Cardiovascular Research, Ninewells Hospital and Medical School, University of Dundee, DD1 9SY Scotland, UK
    Trends Cardiovasc Med 18:109-16. 2008
    ..With its increasing use by other groups, it is anticipated that further published studies will help to provide a better understanding of the development and progression of cardiovascular disease...
  46. ncbi Nebivolol prevents vascular NOS III uncoupling in experimental hyperlipidemia and inhibits NADPH oxidase activity in inflammatory cells
    Hanke Mollnau
    Abteilung fur Kardiologie, Universitats Krankenhaus Eppendorf, University of Hamburg, Hamburg, Germany
    Arterioscler Thromb Vasc Biol 23:615-21. 2003
    ..With the present studies we sought to determine whether beta receptor blockade with nebivolol may improve endothelial function in hyperlipidemia and whether this is attributable to reductions in vascular oxidative stress...
  47. ncbi Noninvasive assessment of endothelial function in the skin microcirculation
    Haythem Debbabi
    Department of Non Invasive Investigations, Cardiovascular Research Centre, PARCC Inserm U970, Lariboisiere Hospital, Paris, France
    Am J Hypertens 23:541-6. 2010
    ..The aim of this study was to determine whether the laser Doppler response of skin microcirculation to acetylcholine, reflects that of conduit artery assessed by brachial artery flow-mediated dilation (FMD)...
  48. ncbi Altered tetrahydrobiopterin metabolism in atherosclerosis: implications for use of oxidized tetrahydrobiopterin analogues and thiol antioxidants
    Jeannette Vasquez-Vivar
    Biophysics Research Institute, Medical College of Wisconsin, Milwaukee, USA
    Arterioscler Thromb Vasc Biol 22:1655-61. 2002
    ..The purpose of this study was to investigate the effects of hyperlipidemia on vascular BH4 levels and the effect of supplementation with sepiapterin in the presence and absence of N-acetylcysteine (NAC)...
  49. ncbi Ultrasonic versus jet nebulization of iloprost in severe pulmonary hypertension
    T Gessler
    Dept of Internal Medicine, Justus-Liebig-University of Giessen, Germany
    Eur Respir J 17:14-9. 2001
    ....
  50. ncbi A new pharmacological treatment for intermittent claudication: results of a randomized, multicenter trial
    H G Beebe
    Jobst Vascular Center, Toledo, Ohio 43606, USA
    Arch Intern Med 159:2041-50. 1999
    ..Effective medication is limited for the relief of intermittent claudication, a common manifestation of arterial occlusive disease. Cilostazol is a potent inhibitor of platelet aggregation with vasodilation effects...
  51. ncbi Delayed inflammation in rat meninges: implications for migraine pathophysiology
    U Reuter
    Stroke and Neurovascular Regulation Laboratory, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Brain 124:2490-502. 2001
    ....
  52. ncbi Allopurinol improves endothelial dysfunction in chronic heart failure
    Colin A J Farquharson
    Department of Clinical Pharmacology and Therapeutics, Ninewells Hospital and Medical School, Dundee, UK
    Circulation 106:221-6. 2002
    ..Xanthine oxidase produces oxidative stress and therefore we examined whether allopurinol improved endothelial dysfunction in chronic heart failure...
  53. ncbi Hypoxic modulation of exogenous nitrite-induced vasodilation in humans
    Abdul R Maher
    Birmingham University, Birmingham, B15 2TT, United Kingdom
    Circulation 117:670-7. 2008
    ..The effect of intra-arterial infusion of nitrite on forearm blood flow and forearm venous volumes was assessed during normoxia and hypoxia...
  54. ncbi Prognostic value of coronary vascular endothelial dysfunction
    Julian P J Halcox
    Cardiology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA
    Circulation 106:653-8. 2002
    ....
  55. ncbi Regadenoson induces comparable left ventricular perfusion defects as adenosine: a quantitative analysis from the ADVANCE MPI 2 trial
    John J Mahmarian
    Methodist DeBakey Heart and Vascular Center, Houston, Texas 77030, USA
    JACC Cardiovasc Imaging 2:959-68. 2009
    ..This study sought to determine whether regadenoson induces left ventricular perfusion defects of similar size and severity as seen with adenosine stress...
  56. ncbi Adenosine as an adjunct to thrombolytic therapy for acute myocardial infarction: results of a multicenter, randomized, placebo-controlled trial: the Acute Myocardial Infarction STudy of ADenosine (AMISTAD) trial
    K W Mahaffey
    Duke Clinical Research Institute, Durham, North Carolina 27715, USA
    J Am Coll Cardiol 34:1711-20. 1999
    ..The Acute Myocardial Infarction STudy of ADenosine (AMISTAD) trial was designed to test the hypothesis that adenosine as an adjunct to thrombolysis would reduce myocardial infarct size...
  57. pmc Endothelial cell dysfunction and the vascular complications associated with type 2 diabetes: assessing the health of the endothelium
    Hong Ding
    School of Medical Sciences, RMIT University, BundooraWest Campus, Bundoora, Vic, Australia
    Vasc Health Risk Manag 1:55-71. 2005
    ..In addition, we consider the question of biomarkers for vascular disease and evaluate their usefulness for the early detection of and their role as contributors to vascular dysfunction...
  58. ncbi Contractile and vasorelaxant effects of hydrogen sulfide and its biosynthesis in the human internal mammary artery
    George D Webb
    Department of Molecular Physiology and Biophysics, University of Vermont, College of Medicine, Health Science Research Facility Building, Burlington, VT 05405, USA
    J Pharmacol Exp Ther 324:876-82. 2008
    ..The possibility that CSE, and the H(2)S it generates, together play a physiological role in regulating the diameter of arteries in humans, as has been demonstrated in rats, should be considered...
  59. ncbi Prophylactic hyperdynamic postoperative fluid therapy after aneurysmal subarachnoid hemorrhage: a clinical, prospective, randomized, controlled study
    A Egge
    Department of Neurosurgery, , Norway
    Neurosurgery 49:593-605; discussion 605-6. 2001
    ..Costs were higher and complications were more frequent for the hyperdynamic therapy group. CONCLUSION: Neither early nor late outcome measures revealed any significant differences between the two subarachnoid hemorrhage treatment models...
  60. pmc Programming of growth, insulin resistance and vascular dysfunction in offspring of late gestation diabetic rats
    Emily M Segar
    Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Clin Sci (Lond) 117:129-38. 2009
    ..Thus the development of diabetes during pregnancy programmes gender-specific insulin resistance and vascular dysfunction in adult offspring...
  61. pmc Second-opinion stress tele-echocardiography for the Adonhers (Aged donor heart rescue by stress echo) project
    Daniele Franchi
    Department of Echocardiography and Medical Informatics, Institute of Clinical Physiology, National Research Council, Via Moruzzi 1, Pisa 56124, Italy
    Cardiovasc Ultrasound 8:20. 2010
    ..This study aimed to verify feasibility of a "second opinion" of digitally transferred images of stress echo results to minimize technical variability in selection of aged donor hearts for heart transplant...
  62. ncbi Validation of magnetic resonance myocardial perfusion imaging with fractional flow reserve for the detection of significant coronary heart disease
    Stuart Watkins
    Golden Jubilee National Hospital, Department of Cardiology, Beardmore St, Clydebank, Glasgow, G81 4HX
    Circulation 120:2207-13. 2009
    ..Pressure wire-derived fractional flow reserve (FFR) values <0.75 correlate closely with objective evidence of reversible ischemia. Accordingly, we have compared MRMPI with FFR...
  63. ncbi Adiponectin is a novel humoral vasodilator
    Gábor Fésüs
    Charite University Medicine Berlin, Germany
    Cardiovasc Res 75:719-27. 2007
    ..We tested the hypothesis that ADRF might be adiponectin and that adiponectin plays a role in the paracrine control of vascular tone by perivascular adipose tissue...
  64. pmc Oxygenation-sensitive CMR for assessing vasodilator-induced changes of myocardial oxygenation
    Matthias Vöhringer
    Stephenson Cardiovascular MR Centre at the Libin Cardiovascular Institute of Alberta, Department of Cardiac Sciences, University of Calgary, Calgary, AB, Canada
    J Cardiovasc Magn Reson 12:20. 2010
    ....
  65. ncbi Coronary microvascular dysfunction and prognosis in hypertrophic cardiomyopathy
    Franco Cecchi
    Regional Referral Center for Myocardial Diseases, Azienda Ospedaliera Careggi, Florence, Italy
    N Engl J Med 349:1027-35. 2003
    ..We prospectively evaluated a cohort of patients with hypertrophic cardiomyopathy after they had undergone quantitative assessment of myocardial blood flow by positron-emission tomography (PET)...
  66. ncbi Differences in heart rate response to adenosine and regadenoson in patients with and without diabetes mellitus
    Fadi G Hage
    Department of Medicine, University of Alabama at Birmingham, 35294 0006, USA
    Am Heart J 157:771-6. 2009
    ..We hypothesized that the HR response will be lower in patients with than in those without diabetes mellitus (DM)...
  67. pmc Direct evidence of nitric oxide release from neuronal nitric oxide synthase activation in the left ventricle as a result of cervical vagus nerve stimulation
    Kieran E Brack
    Cardiology Group, Department of Cardiovascular Sciences, University of Leicester, UK
    J Physiol 587:3045-54. 2009
    ..21%). Activation of cardiac parasympathetic efferent nerve fibres by stimulation of the cervical vagus is associated with NO production and release in the ventricle of the rabbit, via the neuronal isoform of nitric oxide synthase...
  68. ncbi Survival in pulmonary hypertension associated with the scleroderma spectrum of diseases: impact of interstitial lung disease
    Stephen C Mathai
    Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Arthritis Rheum 60:569-77. 2009
    ..This study was undertaken to characterize determinants of survival among SSc patients with either type of PH who received PAH-specific therapy...
  69. ncbi Increased basal coronary blood flow as a cause of reduced coronary flow reserve in diabetic patients
    Andrea Picchi
    Department of Cardiology, Misericordia Hospital, Grosseto, Italy
    Am J Physiol Heart Circ Physiol 301:H2279-84. 2011
    ..Basal coronary flow relates to insulin resistance, suggesting a key role of cellular metabolism in the regulation of coronary blood flow...
  70. ncbi Role of perivascular adipose tissue-derived methyl palmitate in vascular tone regulation and pathogenesis of hypertension
    Yuan Chieh Lee
    Department of Ophthalmology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan
    Circulation 124:1160-71. 2011
    ..Its chemical nature remains unknown. We determined whether palmitic acid methyl ester (PAME) was the PVATRF and whether its release and/or vasorelaxing activity decreased in hypertension...
  71. ncbi Central N-acetylcysteine effects on baroreflex in juvenile spontaneously hypertensive rats
    Vitor E Valenti
    Departamento de Medicina, Disciplina de Cardiologia, Universidade Federal de Sao Paulo UNIFESP, Brazil
    J Integr Neurosci 10:161-76. 2011
    ..05) in WKY rats. In relation to SHR, NAC decreased HR range 15 and 30 minutes after its administration. In conclusion, acute NAC into the 4th V does not improve baroreflex in juvenile SHR...
  72. ncbi Characterization and evaluation of self-microemulsifying sustained-release pellet formulation of puerarin for oral delivery
    Yi Zhang
    School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China
    Int J Pharm 427:337-44. 2012
    ..7% compared with the tablet group. The results demonstrated that the puerarin-SMEDDS sustained-release pellets had a sustained-release effect, and could remarkably improve the oral bioavailability of puerarin...
  73. ncbi Vasodilatory effects of ethanol extract of Radix Paeoniae Rubra and its mechanism of action in the rat aorta
    Song Nan Jin
    Institute of Materia Medica, Taishan Medical University, Taian, Shandong 271016, China
    J Ethnopharmacol 142:188-93. 2012
    ..or Paeonia veitchii Lynch. RPR has a wide variety of pharmacological actions such as anti-thrombus, anti-coagulation, and anti-atherosclerotic properties, protecting heart and liver. However, the mechanisms involved are to be defined...
  74. pmc Regadenoson and adenosine are equivalent vasodilators and are superior than dipyridamole- a study of first pass quantitative perfusion cardiovascular magnetic resonance
    Sujethra Vasu
    Cardiovascular and Pulmonary Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Department of Health and Human Services, 10 Center Drive, Building 10, Room B1D416, 20892 1061 Bethesda, MD, USA
    J Cardiovasc Magn Reson 15:85. 2013
    ..The specific aim of this study was to determine the relative potency of these three vasodilators by quantifying stress and rest myocardial perfusion in humans using cardiovascular magnetic resonance (CMR)...
  75. ncbi Role of Rho-kinase signaling and endothelial dysfunction in modulating blood flow distribution in pulmonary hypertension
    Daryl O Schwenke
    Dept of Physiology, Univ of Otago, Dunedin, New Zealand
    J Appl Physiol (1985) 110:901-8. 2011
    ..Indeed, an effective therapeutic strategy for treating PAH should target both the smooth muscle Rho-kinase and endothelial pathways...
  76. ncbi Comparison of the prognostic value of normal regadenoson with normal adenosine myocardial perfusion imaging with propensity score matching
    Fahad M Iqbal
    Tulane University Heart and Vascular Institute, New Orleans, LA 70112, USA
    JACC Cardiovasc Imaging 5:1014-21. 2012
    ..The aim of this study was to test the hypothesis that patients with normal regadenoson myocardial perfusion imaging (MPI) have a low rate of cardiac events, similar to patients with normal adenosine MPI...
  77. ncbi Dilation by CGRP of middle meningeal artery and reversal by sumatriptan in normal volunteers
    M S Asghar
    Danish Headache Center and Department of Neurology, Glostrup Hospital, University of Copenhagen, Copenhagen, Denmark
    Neurology 75:1520-6. 2010
    ....
  78. ncbi Proliferation, migration, and ERK activation in human retinal endothelial cells through A(2B) adenosine receptor stimulation
    M B Grant
    Department of Medicine, University of Florida, Gainesville 32610 0267, USA
    Invest Ophthalmol Vis Sci 42:2068-73. 2001
    ....
  79. ncbi Influence of perivascular adipose tissue on rat aortic smooth muscle responsiveness
    E E Soltis
    Division of Pharmacology and Experimental Therapeutics, College of Pharmacy, University of Kentucky, Lexington 40536 0082
    Clin Exp Hypertens A 13:277-96. 1991
    ..These observations demonstrate that perivascular adipose tissue significantly influences vascular responsiveness in the in vitro setting...
  80. ncbi ERG evaluation of daily, high-dose sildenafil usage
    Christopher I Zoumalan
    Department of Ophthalmology, Stanford University School of Medicine, Boswell Building, Stanford, CA 94305 5308, USA
    Doc Ophthalmol 118:225-31. 2009
    ..The purpose of our study is to investigate possible ERG changes in subjects using large doses of sildenafil on a chronic daily basis...
  81. ncbi Cilostazol increases tissue blood flow in contracting rabbit gastrocnemius muscle
    Miranda Fong
    Otsuka Maryland Medicinal Laboratories, Inc, Rockville, MD, USA
    Circ J 74:181-7. 2010
    ..In the present study the effect of cilostazol on blood flow and interstitial adenosine concentration was compared with that of the PDE3 inhibitor, milrinone, and the adenosine uptake inhibitor, draflazine...
  82. ncbi Outcomes in children with idiopathic pulmonary arterial hypertension
    Delphine Yung
    Department of Pediatrics, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Circulation 110:660-5. 2004
    ..We sought to determine parameters associated with survival and treatment success...
  83. ncbi High-dosage betahistine dihydrochloride between 288 and 480 mg/day in patients with severe Menière's disease: a case series
    Franziska Lezius
    Department of Neurology, Klinikum Grosshadern, Marchioninistrasse 15, 81377 Munich, Germany
    Eur Arch Otorhinolaryngol 268:1237-40. 2011
    ..Moreover, such dosages are well tolerated...
  84. pmc Hydrogen sulfide dilates cerebral arterioles by activating smooth muscle cell plasma membrane KATP channels
    Guo Hua Liang
    Dept of Physiology, Univ of Tennessee Health Science Ctr, Memphis, TN 38163, USA
    Am J Physiol Heart Circ Physiol 300:H2088-95. 2011
    ..These data indicate that smooth muscle cell K(ATP) currents control newborn cerebral arteriole contractility and that H(2)S dilates cerebral arterioles by activating smooth muscle cell K(ATP) channels containing SUR2 subunits...
  85. ncbi Effect of high-dose intracoronary adenosine administration during primary percutaneous coronary intervention in acute myocardial infarction: a randomized controlled trial
    Marieke L Fokkema
    Thoraxcenter, Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Circ Cardiovasc Interv 2:323-9. 2009
    ..The effect of intracoronary adenosine during primary percutaneous coronary intervention has not been investigated in a large randomized trial...
  86. ncbi Akt/eNOS pathway activation in endothelium-dependent relaxation is preserved in aortas from female, but not from male, type 2 diabetic mice
    Kumiko Taguchi
    Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Shinagawa ku, Tokyo 142 8501, Japan
    Pharmacol Res 65:56-65. 2012
    ....
  87. pmc Effects of sildenafil and tadalafil on intraocular pressure in sheep: implications for aqueous humor dynamics
    Rosana Gerometta
    Departamento de Oftalmologia, Facultad de Medicina, Universidad Nacional del Nordeste, Corrientes, Argentina
    Invest Ophthalmol Vis Sci 51:3139-44. 2010
    ....
  88. pmc Incremental value of adenosine-induced stress myocardial perfusion imaging with dual-source CT at cardiac CT angiography
    Jose A Rocha-Filho
    Department of Radiology, Massachusetts General Hospital, Boston, Mass, USA
    Radiology 254:410-9. 2010
    ....
  89. ncbi Effect of carvedilol on coronary flow reserve in patients with hypertensive left-ventricular hypertrophy
    Huang Xiaozhen
    The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Shandong University Qilu Hospital, Jinan, Shandong, PR China
    Blood Press 19:40-7. 2010
    ..Whether carvedilol can improve CFR of patients with hypertensive LVH is unknown. We aimed to investigate the effects of carvedilol on CFR in patients with hypertensive LVH...
  90. ncbi Prostacyclin treatment in severe traumatic brain injury: a microdialysis and outcome study
    Magnus Olivecrona
    Department of Neurosurgery, Umea University Hospital, Umea, Sweden
    J Neurotrauma 26:1251-62. 2009
    ..This study is a prospective consecutive double-blinded randomized study on the effect of PGI(2) versus placebo in severe traumatic brain injury (sTBI). All patients with sTBI were eligible...
  91. ncbi Differential effects of diabetes on the expression of the gp91phox homologues nox1 and nox4
    Maria C Wendt
    The University Clinics Eppendorf, Division of Cardiology, Hamburg, Germany
    Free Radic Biol Med 39:381-91. 2005
    ..We conclude that in addition to phagocytic NADPH oxidase, also nonphagocytic, vascular NADPH oxidase subunit nox1, uncoupled NOSIII, and plasma xanthine oxidase contribute to endothelial dysfunction in the setting of diabetes mellitus...
  92. ncbi Prognostic implications of dipyridamole cardiac MR imaging: a prospective multicenter registry
    Vicente Bodi
    Department of Cardiology, Hospital Clinico Universitario, INCLIVA, Universidad de Valencia, Blasco Ibanez 17, Valencia 46010, Spain
    Radiology 262:91-100. 2012
    ..To evaluate dipyridamole cardiac magnetic resonance (MR) imaging in the prediction of major events (MEs) in patients with ischemic chest pain in a large multicenter registry...
  93. pmc Diagnostic accuracy of adenosine stress cardiovascular magnetic resonance following acute ST-segment elevation myocardial infarction post primary angioplasty
    Dennis T L Wong
    Cardiovascular Research Centre, Royal Adelaide Hospital and Department of Medicine, University of Adelaide, Adelaide, Australia
    J Cardiovasc Magn Reson 13:62. 2011
    ....
  94. pmc Protection of protease-activated receptor 2 mediated vasodilatation against angiotensin II-induced vascular dysfunction in mice
    Elizabeth Chia
    Memorial University, St, John s, Newfoundland and Labrador, Canada
    BMC Pharmacol 11:10. 2011
    ..We also investigated arterial vasodilatation in angiotensin II-treated PAR2 deficient (PAR2-/-) mice...
  95. ncbi Beta-blockers and coronary flow reserve: the importance of a vasodilatory action
    Maurizio Galderisi
    Cardioangiology Unit with CCU, Department of Clinical and Experimental Medicine, Federico II University Hospital, Naples, Italy
    Drugs 68:579-90. 2008
    ....
  96. ncbi Concordant improvements in coronary flow reserve and ST-segment resolution during percutaneous coronary intervention for acute myocardial infarction: a benefit of postconditioning
    Warren K Laskey
    Division of Cardiology, Department of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131, USA
    Catheter Cardiovasc Interv 72:212-20. 2008
    ..To assess the effect of ischemic postconditioning on indices of coronary microvascular function during percutaneous coronary intervention (PCI) for acute ST segment elevation myocardial infarction (STEMI)...
  97. pmc Feasibility and safety of high-dose adenosine perfusion cardiovascular magnetic resonance
    Theodoros D Karamitsos
    Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, UK
    J Cardiovasc Magn Reson 12:66. 2010
    ..The aim of the present study was to assess the tolerance and safety of a high-dose adenosine protocol in patients with inadequate haemodynamic response to the standard adenosine protocol when undergoing CMR perfusion imaging...
  98. ncbi Vasoconstrictive effect of hydrogen sulfide involves downregulation of cAMP in vascular smooth muscle cells
    Jia Jia Lim
    Dept of Pharmacology, Yong Loo Lin School of Medicine, National Univ of Singapore, Singapore, 117597
    Am J Physiol Cell Physiol 295:C1261-70. 2008
    ..Taken together, we demonstrated for the first time that the vasoconstrictive effect of H(2)S involves the adenyly cyclase/cAMP pathway...
  99. pmc Metoprolol compared to carvedilol deteriorates insulin-stimulated endothelial function in patients with type 2 diabetes - a randomized study
    Britt Kveiborg
    Department of Medicine, Naestved Hospital, Naestved, Denmark
    Cardiovasc Diabetol 9:21. 2010
    ..The aim of this study was to examine the effect of metoprolol versus carvedilol on endothelial function and insulin-stimulated endothelial function in patients with type 2 diabetes...
  100. ncbi A potential mechanism for the impairment of nitric oxide formation caused by prolonged oral exposure to arsenate in rabbits
    Jingbo Pi
    Graduate School Doctoral Program in Medical Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki 305 8575, Japan
    Free Radic Biol Med 35:102-13. 2003
    ..produced from endothelial NOS, such that enhanced free radicals are produced at the expense of NO...
  101. ncbi Inhaled nitric oxide. A selective pulmonary vasodilator reversing hypoxic pulmonary vasoconstriction
    C Frostell
    Department of Anesthesia, Harvard Medical School, Massachusetts General Hospital, Boston
    Circulation 83:2038-47. 1991
    ..Conclusions. Low dose inhaled NO (5-80 ppm) is a selective pulmonary vasodilator reversing both hypoxia- and thromboxane-induced pulmonary hypertension in the awake lamb [corrected]...

Research Grants62

  1. Anti-Fibrotic Therapy for Scleroderma/SSc
    Latha Paka; Fiscal Year: 2010
    ..The objective of this application is to evaluate a lead small- molecule drug candidate in two preclinical models of scleroderma/SSc to advance to SBIR Phase-II project with the ultimate objective of bringing our drug to clinical trials. ..
  2. Markers of Renal Damage in Renovascular Hypertension
    Juan C Romero; Fiscal Year: 2011
    ..Elucidation of all these issues will have enormous clinical repercussion in the diagnosis, follow up, and treatment of renovascular hypertension. ..
  3. Microvascular Dysfunction in Hyperhomocysteinemia
    Shawn E Bearden; Fiscal Year: 2012
    ....
  4. BIOENGINEERING DESIGN OF ARTIFICIAL BLOOD
    Marcos Intaglietta; Fiscal Year: 2011
    ..abstract_text> ..
  5. ROCK inhibitor suppression of GVHD with retention of GVL response
    Sujatha Iyengar; Fiscal Year: 2012
    ..Using ROCK inhibitors for GVHD is novel, and success would accelerate our long term goal of using ROCK inhibitors with BMT, to treat leukemias and other tumors. ..
  6. L-arginine supplement for the prevention of calcineurin inhibitor nephrotoxicity
    W Ray Kim; Fiscal Year: 2011
    ..Once established, there is no effective treatment. This research investigates whether L- arginine can reverse the effects of calcineurin inhibitors on the kidneys and thus prevent renal insufficiency in liver transplant recipients. ..
  7. Anti-Fibrotic Therapy for Scleroderma/SSc
    Latha Paka; Fiscal Year: 2013
    ..We will also evaluate the safety/toxicology profile of ANG3070, in order to assemble a complete IND-enabling preclinical data package to submit to FDA for advancing to human studies. ..
  8. NITRIC OXIDE INTERACTION WITH INSECT NITROPHORINS
    FRANCES ANN WALKER; Fiscal Year: 2012
    ....
  9. Longitudinal Impact of Antihypertensive Polypharmacy on Geriatric Syndromes
    Joseph T Hanlon; Fiscal Year: 2012
    ..e., blood pressure control), and morbidity and mortality (i.e., hospitalization and death due to cardiovascular and cerebrovascular disease). Such studies are consistent with NIA's priority comparative effectiveness research area. ..
  10. Prevention of Diabetic Neuropathy with ACE Inhibitors
    MARK ANTHONY YOREK; Fiscal Year: 2012
    ..If successful, these studies could provide a rationale for designing clinical studies to further test the efficacy of angiotensin converting enzyme and/or vasopeptidase inhibitor treatment in human diabetic neuropathy. ..
  11. Mechanisms of Intracellular NAMPT-regulated GSNOR in Vessel Wall
    ADAM CARL STRAUB; Fiscal Year: 2012
    ....
  12. Mechanisms of Intracellular NAMPT-regulated GSNOR in Vessel Wall
    ADAM CARL STRAUB; Fiscal Year: 2013
    ..abstract_text> ..
  13. Fast calcium responses along arteriolar endothelium in vivo
    Pooneh Bagher; Fiscal Year: 2010
    ..My overall goal is to apply the findings of my research to understanding and treating cardiovascular disease. ..
  14. Circulating biomarkers of IPAH.
    Allen D Everett; Fiscal Year: 2012
    ..Therefore biomarkers could fill this void providing the means to decrease therapeutic morbidity, appropriately escalate therapy and serve as measures to benchmark new therapies. ..
  15. Circulatory system and integrated muscle tissue for drug and tissue toxicity
    George A Truskey; Fiscal Year: 2013
    ..We will examine the response of blood vessels and muscle to an inflammatory stimulus. Metabolic profiling will be performed to simulate different physiological conditions and response to drugs and toxins. ..
  16. Role of Thromboxane in the Exercise Pressor Reflex in Peripheral Artery Disease
    ANNA KATHERINE LEAL; Fiscal Year: 2013
    ..These studies may lead to novel treatments that could potentially increase walking tolerance in individuals suffering from peripheral artery disease and reduce the risks and pain associated with physical activity. ..
  17. Vasodilation via selective pharmacological targeting of BK channel beta1 subunits
    Alex M Dopico; Fiscal Year: 2013
    ..abstract_text> ..
  18. Acute Collateral Enhancement in Focal Stroke
    Al C Ngai; Fiscal Year: 2010
    ..focus on adenosine and adenosine kinase inhibitors, which are clinically-relevant, site and event -specific vasodilator agents that may enhance collateral flow and improve outcome after ischemia...
  19. Vascular control by K+ channel trafficking
    Jonathan H Jaggar; Fiscal Year: 2013
    ..This proposal will provide significant novel information concerning cerebral artery contractility regulation by physiological and pathological mechanisms that control BKCa channel surface expression. ..
  20. Cell-targeted drug delivery for the treatment of pulmonary arterial hypertension
    Masahiko Oka; Fiscal Year: 2012
    ..abstract_text> ..
  21. Adenosine and Epoxyeicosatrienoic Acids
    MAIREAD CARROLL; Fiscal Year: 2010
    ..Selective A2AR agonists may provide a therapeutic approach to controlling blood pressure. ..
  22. Contribution of caveolin to diabetic vascular dysfunction
    Kathryn G Lamping; Fiscal Year: 2013
    ..We will compare the effects of inhibition (siRNA) or overexpression of caveolin-1 using viral transfection on vascular responses to specific serotonin receptor agonists or direct activation of rhoA in non-diabetic and diabetic mice. ..
  23. Longitudinal Impact of Antihypertensive Polypharmacy on Geriatric Syndromes
    Joseph T Hanlon; Fiscal Year: 2010
    ..Studies of the effects of polypharmacy on health, disease, and disability in older persons are a priority research area for the NIA Geriatrics and Clinical Gerontology Program. ..
  24. Quantifiable biomarkers of vasodilator therapeutic response in children with IPAH
    Allen D Everett; Fiscal Year: 2010
    ....
  25. Rapid, noninvasive diagnosis and monitoring of shock
    DONALD SANDERSON PROUGH; Fiscal Year: 2010
    ..The proposed optoacoustic system will replace invasive, intermittent diagnostic testing of central venous blood oxygenation hemoglobin with noninvasive, rapid, and continuous monitoring. ..
  26. Phospholipid-Arachidonate-Eicosanoid Signaling in Schizophrenia
    Jeffrey K Yao; Fiscal Year: 2013
    ..Messamore) to recruit CSz and FDR patients in Portland site at no additional costs. ..
  27. Endothelial BKCa Channels and Hypoxic Pulmonary Endothelial Dysfunction
    Gaurav Choudhary; Fiscal Year: 2013
    ..Aim 3: We will determine the effect of endothelial BKCa activation on endothelial vasodilatory function, EC proliferation and vascular remodeling in response to hypoxia. ..
  28. CHRONIC CORONARY OCCLUSION, EXERCISE TRAINING AND NO
    Cristine L Heaps; Fiscal Year: 2010
    ....
  29. Recombinant annexin A2 plus tPA for combination stroke therapy
    Xiaoying Wang; Fiscal Year: 2013
    ..We believe our proposal should be directly relevant for PA-07-233, "Multidisciplinary Translational Research in Critical Care" (R01). ..
  30. The Microcirculation in OSA
    Rami N Khayat; Fiscal Year: 2012
    ..The result will be immediately applicable to planning needed randomized controlled trials evaluating the effects of treatment of sleep apnea on cardiovascular disease. ..
  31. Endothelial Mechanism of Vascular Cognitive Impariment (VCI)
    Nabil J Alkayed; Fiscal Year: 2013
    ....
  32. Vascular responses as therapeutic targets after SCI
    Scott R Whittemore; Fiscal Year: 2013
    ..Collectively, the experiments outlined in these 3 Aims delineate a strategy to optimally inhibit ER stress in ECs to maximize functional recovery after SCI and determine whether this approach is clinically relevant. ..
  33. Does strial microischemia enhance cochlear aminoglycoside ototoxicity
    Hongzhe Li; Fiscal Year: 2013
    ..The proposed research will determine several risk factors on strial microischemia, and establish a reliable ototoxic mouse model. ..
  34. Mitochondrial Haplotype Influences LV Dysfunction in Heart Failure
    LOUIS JOSEPH DELL'ITALIA; Fiscal Year: 2013
    ..g., c57n:c3hmt or c3hn:c57mt). ..
  35. PERINATAL PULMONARY CIRCULATION--VASOACTIVE MEDIATORS
    Michael Heymann; Fiscal Year: 1999
    ....
  36. MECHANISM OF CORONARY ENDOTHELIUM MEDIATED VASODILATION
    Pin Lan Li; Fiscal Year: 2000
    ..These studies will demonstrate a new signaling pathway for the action of endothelium-derived vasodilators and contribute to our understanding of cellular and molecular mechanism gating K+ channels and regulating coronary vascular tone. ..
  37. K Channel Plasticity and Regulation of Vasomotor Tone
    STEPHEN T O apos ROURKE; Fiscal Year: 2010
    ..g. aging), and developing novel drugs that may be particularly effective in nitrate tolerant patients. ..
  38. Direct Peritoneal Resuscitation from Hypovolemic Shock
    Richard Garrison; Fiscal Year: 2007
    ..abstract_text> ..
  39. PO2 MODULATION OF NO AND ET1 IN PULMONARY HYPERTENSION
    Karen Fagan; Fiscal Year: 2002
    ..Improved understanding of these endogenous vasoregulatory substances, their interactions with one another, and the effect of modest hypoxia in vivo are the major goals of this proposal and may lead to new therapeutic options. ..
  40. MELATONIN AND CEREBRAL BLOOD FLOW AUTOREGULATION
    Mohan Viswanathan; Fiscal Year: 2000
    ..abstract_text> ..
  41. Nitric Oxide and Compensatory Coronary Vasodilation
    David Stepp; Fiscal Year: 2004
    ..This mechanism may contribute to the ability of the coronary circulation to maintain cardiac perfusion and avoid ischemia during the early stages of coronary artery disease when NO-dependent dilation is compromised. ..
  42. Gender and Orthostatic Tolerance
    William Cooke; Fiscal Year: 2001
    ..As an additional specific aim, the research is designed in large part to allow undergraduate students to receive an invaluable introduction to research. ..
  43. Adenosine and Nitric Oxide Deficiency
    Italo Biaggioni; Fiscal Year: 2004
    ....
  44. VASODILATOR-ASSISTED HYPERTHERMIA OF DEEP SEATED TUMORS
    GILBERT NUSSBAUM; Fiscal Year: 1991
    ..Biopsy specimens will be taken prior to experimentation and autopsies will be performed to evaluate perfusion rates and hyperthermia-injury. Experiments will be conducted on 100 dogs over a five year period...
  45. SPLANCHNIC HEMODYNAMICS IN PORTAL HYPERTENSION
    JAMES SITZMANN; Fiscal Year: 1992
    ..The results of these studies will provide information about the pathophysiology of portal hypertension and indicate the hormonal/pharmacologic/anatomic manipulations which would favorably alter the sequelae of portal hypertension...
  46. CYCLIC GMP REGULATION OF SMOOTH MUSCLE CONTRACTILITY
    Robert Rapoport; Fiscal Year: 1990
    ....
  47. MICROVASCULAR ABNORMALITIES IN SEPSIS
    Steven Hollenberg; Fiscal Year: 2002
    ....
  48. DETERMINANTS OF VASODILATOR RESPONSE IN HEART FAILURE
    Milton Packer; Fiscal Year: 1992
    ....
  49. RIGHT VENTRICULAR DYSFUNCTION AND TREATMENT
    Marc Semigran; Fiscal Year: 2003
    ..3. Assess the effects of acute and chronic pulmonary vasodilator and the subsequent decrease in wall stress on the activity of proteins which regulate myocyte apoptosis. ..
  50. COX-2 Mediated Inflammation of Cerebral Blood Vessels
    JOHNNY BRIAN; Fiscal Year: 2002
    ..These studies will introduce an important new concept in the cerebral circulation - that acute dilators such as bradykinin and arachidonic acid can cause changes in gene expression that underlie delayed vascular effects. ..
  51. DETERMINANTS OF PULMONARY ARTERY BLOOD VELOCITY PROFILE
    Carol Lucas; Fiscal Year: 1991
    ..Finally, results obtained in the animal models will be compared to available clinical data, thus testing the belief that better understanding of the determinants of the velocity profile will lead to improved patient diagnosis and care...
  52. VASCULAR MUSCLE CALCIUM CURRENTS IN HYPERTENSION
    NANCY RUSCH; Fiscal Year: 1992
    ....
  53. Aging and Endothelial Function of Muscle Arterioles
    JUDY DELP; Fiscal Year: 2002
    ..Furthermore, these studies will determine whether exercise training can counter the aging-associated loss of endothelium-dependent vasodilatory responses in skeletal muscle resistance arterioles. ..
  54. Vascular Function after Exposure of Humans to Hypoxia
    James Weiss; Fiscal Year: 2009
    ..We anticipate that these studies will significantly enhance our understanding of how intermittent hypoxia and obstructive sleep apnea influence vascular tone and function. ..
  55. CALCITONIN GENE-RELATED PEPTIDE IN HYPERTENSION
    Gianfranco Alpini; Fiscal Year: 2006
    ..abstract_text> ..
  56. REGULATION OF VASCULAR ENDOTHELIN PRODUCTION
    A Whorton; Fiscal Year: 1993
    ....
  57. EFFECTS OF EPOXYEICOSATRIENOIC ACIDS ON KATP CHANNEL
    Hon Chi Lee; Fiscal Year: 2003
    ..It is believed from preliminary data that 11,12 EET caused a decrease in the ATP binding rate. This will be further explored through analysis of these actions on single KATP channels. ..
  58. A2a ADENOSINE RECEPTOR IN REMOTE LV DYSFUNCTION POST-MI
    BRENT FRENCH; Fiscal Year: 2004
    ..We hypothesize that the central importance of cytokine gene activation in remote LV dysfunction can be elucidated by comparing mRNA expression profiles from sham-operated, infarcted and ATL146e-treated hearts. ..
  59. OXYGEN TENSION AND ENDOTHELIUM-DEPENDENT VASODILATION
    Roger Johns; Fiscal Year: 1992
    ....
  60. PHARMACOLOGY OF ISCHEMIC MYOCARDIUM
    David Warltier; Fiscal Year: 1991
    ..These studies should lend important insight as to mechanisms by which certain pharmacological agents relieve myocardial ischemia in patients with coronary artery disease...
  61. ESTROGEN AND CEREBRAL VASODILATION
    Dale Pelligrino; Fiscal Year: 2000
    ..These results should provide important information about the cerebrovascular influences of estrogen. ..
  62. STRUCTURE/FUNCTION STUDIES OF ANTIHEMOSTATIC LIPOCALINS
    WILLIAM MONTFORT; Fiscal Year: 2003
    ..The specific aims of the study are to analyze the mechanisms and structural determinants of activity of nitrophorin 2 and SAPLs 1-3 using functional assays, X-ray crystallography, and site-directed mutagenesis. ..