vasoconstrictor agents

Summary

Summary: Drugs used to cause constriction of the blood vessels.

Top Publications

  1. ncbi Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008
    R Phillip Dellinger
    Cooper University Hospital, Camden, NJ, USA
    Crit Care Med 36:296-327. 2008
  2. ncbi Efficacy and safety of terlipressin in cirrhotic patients with variceal bleeding or hepatorenal syndrome
    Aleksander Krag
    Department of Gastroenterology, Hvidovre University Hospital, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Adv Ther 25:1105-40. 2008
  3. ncbi The role of cyclooxygenase (COX)-2 derived prostanoids on vasoconstrictor responses to phenylephrine is increased by exposure to low mercury concentration
    F M Pecanha
    Departamento de Farmacologia, Universidad Autonoma de Madrid, Madrid, Spain
    J Physiol Pharmacol 61:29-36. 2010
  4. ncbi Hepatorenal syndrome: pathophysiology and management
    Hani M Wadei
    Division of Nephrology and Hypertension, Mayo Clinic College of Medicine, Jacksonville, FL 32216, USA
    Clin J Am Soc Nephrol 1:1066-79. 2006
  5. pmc Ischaemic complications of Glypressin in liver disease: a case series
    Fergal Donnellan
    National Liver Transplant Unit, St Vincent s University Hospital, Dublin, Ireland
    Br J Clin Pharmacol 64:550-2. 2007
  6. ncbi Phenylephrine but not ephedrine reduces frontal lobe oxygenation following anesthesia-induced hypotension
    Peter Nissen
    Department of Anesthesia, Rigshospitalet 2041, University of Copenhagen, Blegdamsvej 9, 2100, Copenhagen Ø, Denmark
    Neurocrit Care 12:17-23. 2010
  7. ncbi Terlipressin and albumin in patients with cirrhosis and type I hepatorenal syndrome
    Sergio Neri
    Department of Internal Medicine and Systemic Diseases, Liver Operative Unit, Catania University Polyclinic, Catania 95123, Italy
    Dig Dis Sci 53:830-5. 2008
  8. pmc Effect of phenylephrine and ephedrine bolus treatment on cerebral oxygenation in anaesthetized patients
    L Meng
    Department of Anesthesiology and Perioperative Care, University of California, Irvine Medical Center, 101 The City Drive South, Bldg 53, Rm 227, Orange, CA 92868, USA
    Br J Anaesth 107:209-17. 2011
  9. ncbi Evidence for a vascular factor in migraine
    Mohammad S Asghar
    Danish Headache Center and Department of Neurology, Glostrup Hospital, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Ann Neurol 69:635-45. 2011
  10. pmc Prolonged infusion of angiotensin II in apoE(-/-) mice promotes macrophage recruitment with continued expansion of abdominal aortic aneurysm
    Debra L Rateri
    Saha Cardiovascular Research Center, University of Kentucky, Lexington, Kentucky, USA
    Am J Pathol 179:1542-8. 2011

Detail Information

Publications302 found, 100 shown here

  1. ncbi Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008
    R Phillip Dellinger
    Cooper University Hospital, Camden, NJ, USA
    Crit Care Med 36:296-327. 2008
    ..To provide an update to the original Surviving Sepsis Campaign clinical management guidelines, "Surviving Sepsis Campaign Guidelines for Management of Severe Sepsis and Septic Shock," published in 2004...
  2. ncbi Efficacy and safety of terlipressin in cirrhotic patients with variceal bleeding or hepatorenal syndrome
    Aleksander Krag
    Department of Gastroenterology, Hvidovre University Hospital, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Adv Ther 25:1105-40. 2008
    ..At present, treatment with terlipressin and albumin is considered the most efficient therapy and should therefore be recommended for the treatment of type 1 HRS-1...
  3. ncbi The role of cyclooxygenase (COX)-2 derived prostanoids on vasoconstrictor responses to phenylephrine is increased by exposure to low mercury concentration
    F M Pecanha
    Departamento de Farmacologia, Universidad Autonoma de Madrid, Madrid, Spain
    J Physiol Pharmacol 61:29-36. 2010
    ..The increased activation of the renin-angiotensin system after mercury treatment might be associated to this increased COX-2 activity...
  4. ncbi Hepatorenal syndrome: pathophysiology and management
    Hani M Wadei
    Division of Nephrology and Hypertension, Mayo Clinic College of Medicine, Jacksonville, FL 32216, USA
    Clin J Am Soc Nephrol 1:1066-79. 2006
  5. pmc Ischaemic complications of Glypressin in liver disease: a case series
    Fergal Donnellan
    National Liver Transplant Unit, St Vincent s University Hospital, Dublin, Ireland
    Br J Clin Pharmacol 64:550-2. 2007
    ..To report three cases of extensive skin necrosis in cirrhotic patients treated with the vasoconstrictor agent terlipressin (Glypressin)...
  6. ncbi Phenylephrine but not ephedrine reduces frontal lobe oxygenation following anesthesia-induced hypotension
    Peter Nissen
    Department of Anesthesia, Rigshospitalet 2041, University of Copenhagen, Blegdamsvej 9, 2100, Copenhagen Ø, Denmark
    Neurocrit Care 12:17-23. 2010
    ..Vasopressor agents are used to correct anesthesia-induced hypotension. We describe the effect of phenylephrine and ephedrine on frontal lobe oxygenation (S(c)O(2)) following anesthesia-induced hypotension...
  7. ncbi Terlipressin and albumin in patients with cirrhosis and type I hepatorenal syndrome
    Sergio Neri
    Department of Internal Medicine and Systemic Diseases, Liver Operative Unit, Catania University Polyclinic, Catania 95123, Italy
    Dig Dis Sci 53:830-5. 2008
    ..Liver and renal function, plasma renin activity, and aldosterone plasma levels were monitored...
  8. pmc Effect of phenylephrine and ephedrine bolus treatment on cerebral oxygenation in anaesthetized patients
    L Meng
    Department of Anesthesiology and Perioperative Care, University of California, Irvine Medical Center, 101 The City Drive South, Bldg 53, Rm 227, Orange, CA 92868, USA
    Br J Anaesth 107:209-17. 2011
    ..The physiological variables responsible for Sct(O2) changes induced by phenylephrine and ephedrine bolus treatment in anaesthetized patients need to be defined...
  9. ncbi Evidence for a vascular factor in migraine
    Mohammad S Asghar
    Danish Headache Center and Department of Neurology, Glostrup Hospital, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Ann Neurol 69:635-45. 2011
    ..Because dismissal of vascular mechanisms seemed premature, we examined diameter of extra- and intracranial vessels in migraine without aura patients...
  10. pmc Prolonged infusion of angiotensin II in apoE(-/-) mice promotes macrophage recruitment with continued expansion of abdominal aortic aneurysm
    Debra L Rateri
    Saha Cardiovascular Research Center, University of Kentucky, Lexington, Kentucky, USA
    Am J Pathol 179:1542-8. 2011
    ..Macrophages immunostained for CD206 more than for iNOS, consistent with an M2 phenotype. In conclusion, prolonged AngII infusion promotes AAA expansion, and is associated with enhanced rupture rates and increased macrophage infiltration...
  11. ncbi Role of NAD(P)H oxidase on vascular alterations in angiotensin II-infused mice
    Agostino Virdis
    CIHR Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Quebec, Canada
    J Hypertens 22:535-42. 2004
    ..Angiotensin (Ang) II stimulates vascular reactive oxygen species generation via NAD(P)H oxidase activation. We investigated whether vascular NAD(P)H oxidase influences structure and function of resistance arteries from Ang II-infused mice...
  12. ncbi Pulse pressure, aortic reactivity, and endothelium dysfunction in old hypertensive rats
    P Chamiot-Clerc
    Medical Research Department, CNRS ESA 8078, Marie Lannelongue Hospital, 92350 Le Plessis-Robinson, France
    Hypertension 37:313-21. 2001
    ....
  13. pmc Rosiglitazone reverses endothelial dysfunction but not remodeling of femoral artery in Zucker diabetic fatty rats
    Xiao Lu
    Department of Biomedical Engineering, Indiana University Purdue University, Indianapolis, IN 46202, USA
    Cardiovasc Diabetol 9:19. 2010
    ..The vascular dysfunction in Zucker diabetic fatty (ZDF) rats was evaluated at different ages along with the effect of treatment with rosiglitazone (Rosi) on endothelial function and mechanical remodeling...
  14. ncbi Capacitative Ca(2+) entry in agonist-induced pulmonary vasoconstriction
    S S McDaniel
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California School of Medicine, San Diego, California 92103, USA
    Am J Physiol Lung Cell Mol Physiol 280:L870-80. 2001
    ..These results suggest that CCE, potentially through transient receptor potential-encoded Ca(2+) channels, plays an important role in agonist-mediated PA contraction...
  15. ncbi Cardiovascular management of septic shock
    R Phillip Dellinger
    Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Section of Critical Care Medicine, Cooper Health System, Camden 08103, USA
    Crit Care Med 31:946-55. 2003
  16. pmc Vitamin E inhibits abdominal aortic aneurysm formation in angiotensin II-infused apolipoprotein E-deficient mice
    Dan Gavrila
    Department of Internal Medicine, University of Iowa, Iowa City, IA, USA
    Arterioscler Thromb Vasc Biol 25:1671-7. 2005
    ..We investigated the hypothesis that vitamin E, an antioxidant with documented efficacy in mice, can attenuate AAA formation during angiotensin II (Ang II) infusion in apolipoprotein E-deficient mice...
  17. pmc A randomized, prospective, double-blind, placebo-controlled trial of terlipressin for type 1 hepatorenal syndrome
    Arun J Sanyal
    Division of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, Virginia Commonwealth University, Richmond, Virginia, USA
    Gastroenterology 134:1360-8. 2008
    ..The aim of this study was to evaluate the efficacy and safety of terlipressin, a systemic arterial vasoconstrictor, for cirrhosis type 1 HRS...
  18. ncbi Perivascular tissue of internal thoracic artery releases potent nitric oxide and prostacyclin-independent anticontractile factor
    Marcin Malinowski
    2nd Department of Cardiac Surgery, Medical University of Silesia, Katowice, Poland
    Eur J Cardiothorac Surg 33:225-31. 2008
    ..We also analyzed the influence of pleural adipose tissue on ITA reactivity...
  19. ncbi Impact of vasopressin on hemodynamic and metabolic function in the decompensatory phase of hemorrhagic shock
    Ken B Johnson
    Department of Anesthesiology, University of Utah School of Medicine, Salt Lake City, UT 84132 2304, USA
    J Cardiothorac Vasc Anesth 20:167-72. 2006
    ..To explore how the potent vasoconstrictive features of vasopressin impact the rate of cardiovascular collapse and metabolic derangements associated with prolonged hemorrhagic shock...
  20. ncbi [A case of ischemic skin necrosis after glypressin therapy in liver cirrhosis]
    Ji Eun Oh
    Department of Internal Medicince, Masan Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea
    Korean J Gastroenterol 51:381-4. 2008
    ..Terlipressin may induce a complication of the ischemic event. In spite of rarity, special attention needs to paid on the peripheral ischemic complication of terlipressin...
  21. ncbi The positive inotropic effect of endothelin-1 is mediated by mitochondrial reactive oxygen species
    V C De Giusti
    Centro de Investigaciones Cardiovasculares, Facultad de Ciencias Medicas, Universidad Nacional de La Plata, La Plata, Buenos Aires, Argentina
    Life Sci 83:264-71. 2008
    ..The data show that the effect of a concentration of ET-1 that induces an increase in contractility of about 40% is totally mediated by an intracellular pathway triggered by mitochondrial ROS formation and stimulation of the NHE...
  22. pmc Postoperative inotrope and vasopressor use following CABG: outcome data from the CAPS-care study
    Judson B Williams
    Duke Clinical Research Institute, Durham, North Carolina 27715, USA
    J Card Surg 26:572-8. 2011
    ..Limited clinical data exist to guide practice patterns and evidence-based use of inotropes and vasopressors following coronary artery bypass grafting (CABG)...
  23. ncbi Central N-acetylcysteine effects on baroreflex in juvenile spontaneously hypertensive rats
    Vitor E Valenti
    Departamento de Medicina, Disciplina de Cardiologia, Universidade Federal de Sao Paulo UNIFESP, Brazil
    J Integr Neurosci 10:161-76. 2011
    ..05) in WKY rats. In relation to SHR, NAC decreased HR range 15 and 30 minutes after its administration. In conclusion, acute NAC into the 4th V does not improve baroreflex in juvenile SHR...
  24. ncbi Dilation by CGRP of middle meningeal artery and reversal by sumatriptan in normal volunteers
    M S Asghar
    Danish Headache Center and Department of Neurology, Glostrup Hospital, University of Copenhagen, Copenhagen, Denmark
    Neurology 75:1520-6. 2010
    ....
  25. pmc Lactate clearance vs central venous oxygen saturation as goals of early sepsis therapy: a randomized clinical trial
    Alan E Jones
    Department of Emergency Medicine, 1000 Blythe Blvd, Carolinas Medical Center, Charlotte, NC 28203, USA
    JAMA 303:739-46. 2010
    ..Goal-directed resuscitation for severe sepsis and septic shock has been reported to reduce mortality when applied in the emergency department...
  26. ncbi Vasopressin compared with norepinephrine augments the decline of plasma cytokine levels in septic shock
    James A Russell
    James Hogg Research Centre, St Paul s Hospital, University of British Columbia, Vancouver, British Columbia, Canada
    Am J Respir Crit Care Med 188:356-64. 2013
    ..Changes in plasma cytokine levels may predict mortality, and therapies (vasopressin versus norepinephrine) could change plasma cytokine levels in early septic shock...
  27. pmc Predictors of response to terlipressin plus albumin in hepatorenal syndrome (HRS) type 1: relationship of serum creatinine to hemodynamics
    Thomas D Boyer
    Dept of Medicine, University of Arizona, College of Medicine, Tucson, AZ, United States
    J Hepatol 55:315-21. 2011
    ..However, only about 1/3 of patients respond to treatment, therefore, predictors of response and survival would help identify the patients most likely to benefit from treatment...
  28. ncbi Angiotensin II Ca2+ signaling in rat afferent arterioles: stimulation of cyclic ADP ribose and IP3 pathways
    Susan K Fellner
    Dept of Cell and Molecular Physiology, Univ of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7545, USA
    Am J Physiol Renal Physiol 288:F785-91. 2005
    ....
  29. ncbi Reversal of type 1 hepatorenal syndrome with the administration of midodrine and octreotide
    P Angeli
    Department of Clinical and Experimental Medicine, University of Padua, Padova, Italy
    Hepatology 29:1690-7. 1999
    ..Only one patient recovered renal function and underwent liver transplantation. In conclusion, the long-term administration of midodrine and octreotide seems to be an effective and safe treatment of type 1 HRS in patients with cirrhosis...
  30. ncbi Influence of type II diabetes on arterial tone and endothelial function in murine mesenteric resistance arteries
    G J Lagaud
    Vancouver Vascular Biology Research Centre, Department of Cardiovascular Research, St Paul s Hospital, Vancouver, Canada
    J Vasc Res 38:578-89. 2001
    ..Therefore, heightened activation of PKC(beta) and release of a vasoconstrictor prostanoid could play a role in endothelial dysfunction associated with type II diabetes...
  31. pmc Impairment of coronary endothelial cell ET(B) receptor function after short-term inhalation exposure to whole diesel emissions
    Tom W Cherng
    Physiology Group, Dept of Cell Biology and Physiology, Univ of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
    Am J Physiol Regul Integr Comp Physiol 297:R640-7. 2009
    ....
  32. pmc Novel insights into the mechanisms mediating the local antihypertrophic effects of cardiac atrial natriuretic peptide: role of cGMP-dependent protein kinase and RGS2
    Michael Klaiber
    Institute of Physiology, University of Wurzburg, Physiologisches Institut der Universität Würzburg, Germany
    Basic Res Cardiol 105:583-95. 2010
    ..Furthermore, they strengthen published observations in neonatal cardiomyocytes showing that TRPC3/TRPC6 channels are essential for Ang II, but not for beta-adrenergic Ca(2+) (i)-stimulation in adult myocytes...
  33. ncbi Terlipressin and albumin vs albumin in patients with cirrhosis and hepatorenal syndrome: a randomized study
    Marta Martín-Llahí
    Liver Unit, Hospital Clinic, University of Barcelona School of Medicine, Institut d Investigacions Biomédiques August Pi Sunyer IDIBAPS, Centro de Investigacion Biomedica en Red de Enfermedades Hepaticas y Digestivas CIBERehd, Barcelona, Spain
    Gastroenterology 134:1352-9. 2008
    ..Hepatorenal syndrome is common in patients with advanced cirrhosis and constitutes a major problem in liver transplantation. There is no effective medical treatment for hepatorenal syndrome...
  34. pmc Thromboxane A2-induced contraction of rat caudal arterial smooth muscle involves activation of Ca2+ entry and Ca2+ sensitization: Rho-associated kinase-mediated phosphorylation of MYPT1 at Thr-855, but not Thr-697
    David P Wilson
    Smooth Muscle Research Group and Department of Biochemistry and Molecular Biology, University of Calgary Faculty of Medicine, 3330 Hospital Drive N W, Calgary, Alberta, Canada T2N 4N1
    Biochem J 389:763-74. 2005
    ....
  35. ncbi A systematic review of cardiovascular effects of epinephrine on hypertensive dental patients
    James D Bader
    School of Dentistry, Sheps Center for Health Services Research, University of North Carolina, Chapel Hill, NC 27599, USA jim_baderunc edu
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 93:647-53. 2002
    ....
  36. ncbi The effects of vasopressin on acute kidney injury in septic shock
    Anthony C Gordon
    Intensive Care Unit, Charing Cross Hospital, Imperial College NHS Trust, Fulham Palace Road, London W6 8RF, UK
    Intensive Care Med 36:83-91. 2010
    ..To compare the effects of vasopressin versus norepinephrine infusion on the outcome of kidney injury in septic shock...
  37. ncbi Systematic review of randomized trials on vasoconstrictor drugs for hepatorenal syndrome
    Lise L Gluud
    Department of Internal Medicine, Copenhagen University Hospital Gentofte, Hellerup, Denmark
    Hepatology 51:576-84. 2010
    ..81; 95% CI, 0.68-0.97). The effect was seen in subgroup analyses of type 1 but not type 2 HRS. The remaining trials were small and found no beneficial or harmful effects of the treatments assessed...
  38. ncbi Deficiency of M2 muscarinic acetylcholine receptors increases susceptibility of ventricular function to chronic adrenergic stress
    Carly LaCroix
    Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, SD 57069, USA
    Am J Physiol Heart Circ Physiol 294:H810-20. 2008
    ..The overall results from this study suggest that M(2)-AChR-mediated PSNS function may provide cardiac protection. Lack of this protective mechanism will increase the susceptibility of the heart to cardiac stresses...
  39. pmc Impaired vasoconstriction and nitric oxide-mediated relaxation in pulmonary arteries of hypoxia- and monocrotaline-induced pulmonary hypertensive rats
    Virak Mam
    Division of Vascular Surgery, Harvard Medical School, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Pharmacol Exp Ther 332:455-62. 2010
    ....
  40. ncbi Cerebrovascular ETB, 5-HT1B, and AT1 receptor upregulation correlates with reduction in regional CBF after subarachnoid hemorrhage
    Saema Ansar
    Department of Clinical Sciences, Division of Experimental Vascular Research, Lund University, 221 84 Lund, Sweden
    Am J Physiol Heart Circ Physiol 293:H3750-8. 2007
    ..These changes occur in parallel with a successive decrease in CBF. Thus there is a temporal correlation between the changes in receptor expression and CBF reduction, suggesting a linkage...
  41. ncbi Effect of terlipressin (Glypressin) on hepatorenal syndrome in cirrhotic patients: results of a multicentre pilot study
    Chantal Halimi
    Service d Hepato Gastroenterologie, Centre Hospitalier de Senlis, Paris, France
    Eur J Gastroenterol Hepatol 14:153-8. 2002
    ..Promising results have been shown with this drug. The purpose of this multicentre retrospective study was to evaluate the effects of terlipressin on renal function and survival of patients with HRS...
  42. ncbi Effects of norepinephrine on static and dynamic preload indicators in experimental hemorrhagic shock
    Semir Nouira
    Medical Intensive Care Unit, Fattouma Bourguiba University Hospital, Monastir 5000, Tunisia
    Crit Care Med 33:2339-43. 2005
    ....
  43. ncbi Influence of vasopressor agent in septic shock mortality. Results from the Portuguese Community-Acquired Sepsis Study (SACiUCI study)
    Pedro R Póvoa
    Medical Intensive Care Unit, São Francisco Xavier Hospital, Lisbon, Portugal
    Crit Care Med 37:410-6. 2009
    ..Guidelines for the adrenergic support of septic shock are controversial. In patients with community-acquired septic shock, we assessed the impact of the choice of vasopressor support on mortality...
  44. ncbi Enhanced contraction to 5-hydroxytryptamine is not due to "unmasking" of 5-hydroxytryptamine(1b) receptors in the mesenteric artery of the deoxycorticosterone acetate-salt rat
    A K Banes
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824, USA
    Hypertension 38:891-5. 2001
    ..These data support the conclusions that 5-HT(1B) receptors mediate contraction in mesenteric arteries from hypertensive rats and that this enhanced response to 5-HT is not due to membrane depolarization alone...
  45. ncbi Kisspeptins are novel potent vasoconstrictors in humans, with a discrete localization of their receptor, G protein-coupled receptor 54, to atherosclerosis-prone vessels
    Emma J Mead
    Clinical Pharmacology Unit, University of Cambridge, Centre for Clinical Investigation, Addenbrooke s Hospital, Cambridge, CB2 2QQ, UK
    Endocrinology 148:140-7. 2007
    ....
  46. pmc Continuous terlipressin versus vasopressin infusion in septic shock (TERLIVAP): a randomized, controlled pilot study
    Andrea Morelli
    Department of Anesthesiology and Intensive Care, University of Rome, La Sapienza, Viale del Policlinico 155, Rome 00161, Italy
    Crit Care 13:R130. 2009
    ....
  47. ncbi Hydrogen peroxide acts as both vasodilator and vasoconstrictor in the control of perfused mouse mesenteric resistance arteries
    Pamela A Lucchesi
    University of Alabama at Birmingham, Department of Physiology and Biophysics, Birmingham, Alabama, USA
    J Hypertens 23:571-9. 2005
    ..Hydrogen peroxide (H2O2) plays a key role in the control of resistance artery (RA) tone and is hypothesized as an endothelial-derived hyperpolarizing factor...
  48. ncbi Regulation of angiotensin II-stimulated osteopontin expression in cardiac microvascular endothelial cells: role of p42/44 mitogen-activated protein kinase and reactive oxygen species
    Z Xie
    Myocardial Biology Unit, Boston Medical Center, Boston Veterans Affairs Medical Center, 650 Albany Street, Boston, MA 02118, USA
    J Cell Physiol 188:132-8. 2001
    ..These results suggest that p42/44 MAPK is a critical component of the ROS-sensitive signaling pathways activated by ANG II in CMEC and plays a key role in the regulation of osteopontin gene expression. Published 2001 Wiley-Liss, Inc...
  49. ncbi 17beta-estradiol decreases vascular tone in cerebral arteries by shifting COX-dependent vasoconstriction to vasodilation
    Jose A Ospina
    Department of Pharmacology, College of Medicine, University of California, Irvine, CA 92697 4625, USA
    Am J Physiol Heart Circ Physiol 285:H241-50. 2003
    ..These effects of estrogen may contribute to the heightened thromboresistance and enhanced cerebral blood flow documented in pre-versus postmenopausal women...
  50. pmc Diagnosis, prevention and treatment of hepatorenal syndrome in cirrhosis
    Francesco Salerno
    Department of Internal Medicine, Policlinico IRCCS San Donato, University of Milan, Via Morandi, 30, 20097 San Donato MI, Italy
    Gut 56:1310-8. 2007
  51. ncbi Characterization of small arteries isolated from the human placental chorionic plate
    M Wareing
    Maternal and Fetal Health Research Centre, University of Manchester, Academic Unit of Obstetrics and Gynaecology and Reproductive Health Care, St Mary s Hospital, Whitworth Park, Manchester, M13 0JH, UK
    Placenta 23:400-9. 2002
    ..Relaxations were only achieved with endothelial-independent agonists (sodium nitroprusside and papaverine)...
  52. ncbi Prophylactic ephedrine prevents hypotension during spinal anesthesia for Cesarean delivery but does not improve neonatal outcome: a quantitative systematic review
    Anna Lee
    Department of Anaesthesia, Intensive Care, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong, China
    Can J Anaesth 49:588-99. 2002
    ..The objective of this systematic review was to assess the effectiveness and safety of ephedrine compared with control when given prophylactically to prevent hypotension during spinal anesthesia for Cesarean delivery...
  53. ncbi An open label, pilot, randomized controlled trial of noradrenaline versus terlipressin in the treatment of type 1 hepatorenal syndrome and predictors of response
    Praveen Sharma
    Department of Gastroenterology, G B Pant Hospital, New Delhi, India
    Am J Gastroenterol 103:1689-97. 2008
    ..PATIENTS AND Forty consecutive patients with HRS-1 were randomized to receive noradrenaline 0.5-3.0 mg/h and..
  54. pmc [(125)I]-(Pyr(1))Apelin-13 is a novel radioligand for localizing the APJ orphan receptor in human and rat tissues with evidence for a vasoconstrictor role in man
    S D Katugampola
    Clinical Pharmacology Unit, University of Cambridge, Level 6, Centre for Clinical Investigation, Box 110, Addenbrooke s Hospital, Cambridge, CB2 2QQ
    Br J Pharmacol 132:1255-60. 2001
    ..The maximum response elicited by the peptide was 22.6+/-6% of 100 mM KCl. 6. We provide the first evidence of APJ receptor expression, relative densities and functional properties of (Pyr(1))Apelin-13 in human cardiovascular tissue...
  55. pmc Effects of changes in arterial pressure on organ perfusion during septic shock
    Aurélie Thooft
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Route de Lennik 808, 1070 Brussels, Belgium
    Crit Care 15:R222. 2011
    ..The aim of this study was to assess the effects of increasing MAP using norepinephrine (NE) on hemodynamic and metabolic variables and on microvascular reactivity in patients with septic shock...
  56. ncbi Vasopressin vs. terlipressin in the treatment of cardiovascular failure in sepsis
    Matthias Lange
    Department of Anesthesiology and Intensive Care, University of Munster, Albert Schweitzer Strasse 33, 48149 Munster, Germany
    Intensive Care Med 34:821-32. 2008
    ..We briefly describe the pathophysiology and pharmacology of septic shock relevant to the treatment with vasopressin analogues. In addition, differences in pharmacokinetics and pharmacodynamics between AVP and TP are discussed...
  57. ncbi Effect of chronic hypoxia on voltage-independent calcium influx activated by 5-HT in rat intrapulmonary arteries
    Lise Rodat
    Universite Bordeaux 2, Laboratoire de Physiologie Cellulaire Respiratoire, 146 rue Leo Saignat, F33076 Bordeaux, France
    Pflugers Arch 454:41-51. 2007
    ....
  58. ncbi The anesthetic efficacy of 4 percent articaine 1:200,000 epinephrine: two controlled clinical trials
    Paul A Moore
    Department of Anesthesiology, Oral Health Science Institute, School of Dental Medicine, University of Pittsburgh, 552 Salk Hall, Pittsburgh, PA 15261, USA
    J Am Dent Assoc 137:1572-81. 2006
    ....
  59. ncbi Continuous terlipressin infusion as rescue treatment in a case series of children with refractory septic shock
    Antonio Rodríguez-Núñez
    Hospital Clinico Universitario de Santiago de Compostela, Spain
    Ann Pharmacother 44:1545-53. 2010
    ..Despite intensive therapy, refractory pediatric septic shock has a high rate of morbidity and mortality. Additional treatments are needed to improve outcomes in such cases...
  60. ncbi Terlipressin causing a hyponatraemic seizure
    Elaine Dunwoodie
    Scand J Gastroenterol 42:665. 2007
  61. ncbi Regulator of G protein signalling 2 ameliorates angiotensin II-induced hypertension in mice
    Hantz C Hercule
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Exp Physiol 92:1014-22. 2007
    ..Our findings suggest that RGS2 deletion promotes Ang II-dependent hypertension primarily through an increase of myogenic tone and vasoreactivity, probably by sensitization of AT(1) receptors...
  62. ncbi Rescue therapy with terlipressin by continuous infusion in a child with catecholamine-resistant septic shock
    Gonzalo Zeballos
    Pediatric Critical Care Unit, Gregorio Marañón University Hospital, Dr Castelo, 49, 28007 Madrid, Spain
    Resuscitation 68:151-3. 2006
    ..This case shows the potential value of terlipressin infusion to restore normal mean arterial pressure in children with vasodilatory shock and hypotension refractory to catecholamines...
  63. ncbi Sildenafil in severe peripheral ischemia induced by terlipressin. A case report
    David D Bañuelos Ramírez
    Specialty Consult Rheumatology, Unidad Médica Alta Especialidad, Hospital de Especialidades, Centro Medico Nacional, Instituto Mexicano del Seguro Social, Puebla, Pue, Mexico
    Reumatol Clin 7:59-60. 2011
    ..The vasodilator action of sildenafil is useful in cases of ischemia induced by some drugs. The objective this report is to warm about the utility of sildenafil in some potentially severe cases, like the one above...
  64. ncbi Terlipressin-induced hyponatremic seizure
    Jong Jin Hyun
    Department of Internal Medicine, Institute of Digestive Disease and Nutrition, Korea University College of Medicine, Seoul, South Korea
    Scand J Gastroenterol 45:501-4. 2010
    ..Therefore, it is necessary to carefully monitor patients' electrolyte levels during the course of terlipressin therapy...
  65. ncbi Terlipressin: a promising vasoactive agent in hemodynamic support of septic shock
    Andrea Morelli
    Department of Anesthesiology and Intensive Care, University of Rome La Sapienza, Rome 00161, Italy
    Expert Opin Pharmacother 10:2569-75. 2009
    ..Owing to its high and relatively selective affinity to vascular V1 receptors, terlipressin is also increasingly used as an adjunct vasopressor agent in the management of vasodilatory hyperdynamic septic shock...
  66. ncbi Hemodynamic effects of ephedrine, phenylephrine, and the coadministration of phenylephrine with oxytocin during spinal anesthesia for elective cesarean delivery
    Robert A Dyer
    Department of Anesthesia, University of Cape Town and New Groote Schuur Hospital, Anzio Road, Observatory, Cape Town, South Africa
    Anesthesiology 111:753-65. 2009
    ..The hypothesis was that phenylephrine, but not ephedrine, decreases CO when administered in response to hypotension during spinal anesthesia...
  67. ncbi Terlipressin versus adrenaline in an infant animal model of asphyxial cardiac arrest
    Jesús López-Herce
    Pediatric Intensive Care Service, Hospital General Universitario Gregorio Maranon, Dr Castelo 47, 28009, Madrid, Spain
    Intensive Care Med 36:1248-55. 2010
    ..The objective of this study was to compare the efficacy of terlipressin versus adrenaline in an experimental infant animal model of asphyxial cardiac arrest (ACA)...
  68. ncbi Pediatric cardiac arrest refractory to advanced life support: is there a role for terlipressin?
    Javier Gil-Antón
    Pediatric Intensive Care Unit, Hospital de Cruces, Barakaldo, Bizkaia, Spain
    Pediatr Crit Care Med 11:139-41. 2010
    ....
  69. ncbi Terlipressin in hepatorenal syndrome: Evidence for present indications
    Harshal Rajekar
    Department of General Surgery, Post Graduate Institute of Medical Education and Research, Chandigarh, India
    J Gastroenterol Hepatol 26:109-14. 2011
    ..Thus, the use of Terlipressin has been shown to be safe, with minimal side effects that usually disappear after dose reduction, and results in an improved outcome in patients with HRS...
  70. ncbi Noradrenalin vs terlipressin in patients with hepatorenal syndrome: a prospective, randomized, unblinded, pilot study
    C Alessandria
    Division of Gastroenterology and Hepatology, San Giovanni Battista Hospital, Torino, Italy
    J Hepatol 47:499-505. 2007
    ..Terlipressin is the one with the soundest evidence. Noradrenalin has been suggested as an effective alternative. The current study was aimed at assessing the efficacy and safety of noradrenalin vs terlipressin in patients with HRS...
  71. ncbi [A case of peripheral ischemic complication after terlipressin therapy]
    Jong Sup Lee
    Department of Internal Medicine, Institute of Digestive Diseases and Nutrition, Korea University College of Medicine, Seoul, Korea
    Korean J Gastroenterol 47:454-7. 2006
    ..Ischemic complication of terlipressin is rare and there has been no case report in Korea. Although it is rare, we must pay attention to the peripheral ischemic complication of terlipressin...
  72. ncbi Two observations raising questions about risk factors of cutaneous necrosis induced by terlipressin (Glypressin)
    Hala Megarbane
    Department of Dermatology and Allergology, Hopital Tenon, Universite Pierre et Marie Curie Paris VI, Paris, France
    Dermatology 218:334-7. 2009
    ..Ischemic complications are rare but may be life threatening...
  73. pmc Alterations in phenylephrine-induced contractions and the vascular expression of Na+,K+-ATPase in ouabain-induced hypertension
    Luciana V Rossoni
    Department of Pharmacology and Therapeutics, Facultad de Medicina, Universidad Autonoma de Madrid, Spain
    Br J Pharmacol 135:771-81. 2002
    ..These results suggest that chronic administration of ouabain induces hypertension and regional vascular alterations, the latter possibly as a consequence of the hypertension...
  74. ncbi Rho-kinase-mediated regulation of receptor-agonist-stimulated smooth muscle contraction
    Ming Ho Tsai
    Institute of Basic Medical Sciences, National Cheng Kung University College of Medicine, Tainan, Taiwan
    Pflugers Arch 453:223-32. 2006
    ..Furthermore, Rho kinase regulates actin polymerization activated by alpha(1)-adrenoceptors but is less significant in thromboxane receptor stimulation...
  75. ncbi Atorvastatin prevents angiotensin II-induced vascular remodeling and oxidative stress
    Ana M Briones
    Departmento de Farmacologia, Universidad Autonoma de Madrid, Spain
    Hypertension 54:142-9. 2009
    ..These effects might be mediated by their antioxidant properties...
  76. ncbi Clinical implications of provocation tests for coronary artery spasm: safety, arrhythmic complications, and prognostic impact: multicentre registry study of the Japanese Coronary Spasm Association
    Yusuke Takagi
    Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Aoba ku, Sendai, Japan
    Eur Heart J 34:258-67. 2013
    ..We aimed to elucidate the safety and the clinical implications of the spasm provocation tests in the nationwide multicentre registry study by the Japanese Coronary Spasm Association...
  77. ncbi Naloxone and epinephrine are equally effective for cardiopulmonary resuscitation in a rat asphyxia model
    M H Chen
    Institute of Cardiovascular Diseases, First Affiliated Hospital of Guangxi Medical University, Nanning, China
    Acta Anaesthesiol Scand 50:1125-30. 2006
    ..The aim of the study was to compare the effects of naloxone and epinephrine on the outcomes of CPR following asphyxial cardiac arrest in rats...
  78. ncbi Increased blood pressure in the offspring of diabetic mothers
    Rogerio B Wichi
    Nephrology Department, Federal University of Sao Paulo, Brazil
    Am J Physiol Regul Integr Comp Physiol 288:R1129-33. 2005
    ..min-1 mg protein-1, OD vs. OC). Results suggest that diabetes during pregnancy affects cardiovascular function in offspring, seen as hypertension, baroreflex dysfunction, and activation of tissue renin-angiotensin system...
  79. ncbi Differential vasoconstrictions induced by angiotensin II: role of AT1 and AT2 receptors in isolated C57BL/6J mouse blood vessels
    Yingbi Zhou
    Department of Physiology and Cell Biology, Ohio State Univ College of Medicine and Public Health, Columbus, OH 43210, USA
    Am J Physiol Heart Circ Physiol 285:H2797-803. 2003
    ..These results demonstrate that major mouse vessels exhibit differential contractions to ANG II, possibly because of varied AT1 receptor levels...
  80. ncbi Location of focal vasospasm provoked by ergonovine maleate within coronary arteries in patients with vasospastic angina pectoris
    Tomomi Koizumi
    Center for Research in Cardiovascular Interventions, Division of Cardiovascular Medicine, Stanford University, Stanford, California, USA
    Am J Cardiol 97:1322-5. 2006
    ..01), corresponding to the historical high-risk zones for acute coronary occlusion. More plaque burden also existed in the proximal third of the coronary arteries in patients with focal vasospasm...
  81. ncbi Influence of enantiomers of 1-naphthylalanine in position 2 of VAVP and dVAVP on their pharmacological properties
    Izabela Derdowska
    Department of Chemistry, University of Gdansk, Sobieskiego 18, 80 952 Gdansk, Poland
    Eur J Med Chem 40:63-8. 2005
    ..Our results open new possibilities for the design of very potent and selective oxytocin antagonists in vitro...
  82. ncbi Effects of levobupivacaine and ropivacaine on rat sciatic nerve blood flow
    H Bouaziz
    Department of Anaesthesia and Intensive Care Medicine, Nancy University Hospitals, Nancy, France
    Br J Anaesth 95:696-700. 2005
    ..The aim of this study was to test the effects of levobupivacaine and ropivacaine in a rat sciatic nerve model with respect to local blood flow and histopathological changes...
  83. ncbi Induced hypertension improves cerebral blood flow in acute ischemic stroke
    Julio A Chalela
    Stroke Diagnostics and Therapeutics Section, NINDS NIH, 10 Center Dr, Room B1D733, MSC 1063, Bethesda, MD 20892, USA
    Neurology 64:1979. 2005
  84. ncbi Vitamin E supplementation reverses renal altered vascular reactivity in chronic bile duct-ligated rats
    A Alcaraz
    Departamento de Fisiologia, Facultad de Medicina, Universidad de Murcia, Murcia, Spain
    Am J Physiol Regul Integr Comp Physiol 292:R1486-93. 2007
    ..In conclusion, BDL rats showed a blunted vascular reactivity to phenylephrine and ACh, more pronounced in the kidney and reversed by vitamin E pretreatment, suggesting a role for oxidative stress in those abnormalities...
  85. ncbi Analogues of neurohypophyseal hormones, oxytocin and arginine vasopressin, conformationally restricted in the N-terminal part of the molecule
    Wioleta Kowalczyk
    Faculty of Chemistry, University of Gdansk, Sobieskiego 18, 80 952 Gdansk, Poland
    J Med Chem 49:2016-21. 2006
    ..The results of these assays showed that the reduction of conformational freedom of the N-terminal part of the molecule had a significant impact on pharmacological activities...
  86. ncbi The pharmacokinetics and cardiovascular effects of high-dose articaine with 1:100,000 and 1:200,000 epinephrine
    Elliot V Hersh
    Oral and Maxillofacial Surgery and Pharmacology, School of Dental Medicine, University of Pennsylvania, 240 South 40th St, Philadelphia, PA 19104 6003, USA
    J Am Dent Assoc 137:1562-71. 2006
    ..9 milliliters of 4 percent articaine hydrochloride (HCl) plus 1:100,000 epinephrine (A100) with those of 11.9 mL of 4 percent articaine HCl plus 1:200,000 epinephrine (A200)...
  87. ncbi The effect of mode of delivery on placental chorionic plate vascular reactivity
    Tracey A Mills
    Division of Human Development, The University of Manchester, Manchester, UK
    Hypertens Pregnancy 26:201-10. 2007
    ..To determine whether delivery mode influences placental chorionic plate arterial and venous vascular reactivity...
  88. ncbi Reversal of hepatorenal syndrome in cirrhotic patients with terlipressin plus albumin. First experience in Mexico
    Linda E Muñoz
    Liver Unit, Universidad Autonoma de Nuevo Leon, Monterrey, Nuevo Leon, Mexico
    Ann Hepatol 8:207-11. 2009
    ..Type 1 hepatorenal syndrome (HRS) is a functional renal failure that complicates end-stage cirrhosis. The vasopressin analogue terlipressin has been associated with improved renal function in patients with type 1 HRS...
  89. ncbi Hemodynamic and metabolic effects of low-dose vasopressin infusions in vasodilatory septic shock
    I Tsuneyoshi
    Division of Intensive Care Medicine, Kagoshima University Hospital, Kagoshima, Japan
    Crit Care Med 29:487-93. 2001
    ..To investigate the physiologic effects of exogenous vasopressin as a potential alternative to traditional high-dose catecholamine therapy for septic patients with vascular hyporeactivity to catecholamines...
  90. ncbi Vasoactive drugs in the intensive care unit
    Cheryl L Holmes
    Department of Medicine, University of British Columbia, Kelowna General Hospital, Kelowna, British Columbia, Canada
    Curr Opin Crit Care 11:413-7. 2005
    ..In this review, studies published during the past year that increase our understanding of the use of vasoactive drugs in the intensive care unit are discussed...
  91. ncbi Comparison of dopamine and norepinephrine in the treatment of shock
    Daniel De Backer
    Department of Intensive Care, Erasme University Hospital, Brussels, Belgium
    N Engl J Med 362:779-89. 2010
    ..Both dopamine and norepinephrine are recommended as first-line vasopressor agents in the treatment of shock. There is a continuing controversy about whether one agent is superior to the other...
  92. pmc Activation of prostaglandin E2 EP1 receptor increases arteriolar tone and blood pressure in mice with type 2 diabetes
    Ibolya Rutkai
    Division of Clinical Physiology, Institute of Cardiology, University of Debrecen, Debrecen, Hungary
    Cardiovasc Res 83:148-54. 2009
    ..We tested the hypothesis that activation of type 1 prostaglandin E(2) (PGE(2)) receptor (EP1) increases skeletal muscle arteriolar tone and blood pressure in mice with type 2 diabetes...
  93. ncbi Continuous low-dose infusion of terlipressin as a rescue therapy in meningococcal septic shock
    Fabrice Michel
    Departement d Anesthesie Reanimation, Unité de réanimation pédiatrique et néonatale, Centre Hospitalo Universitaire Nord, 13915 Marseille Cedex 20, France
    Am J Emerg Med 25:863.e1-2. 2007
  94. ncbi Vasoactive drugs for vasodilatory shock in ICU
    Cheryl L Holmes
    Department of Medicine, Kelowna General Hospital, University of British Columbia, Kelowna, British Columbia, Canada
    Curr Opin Crit Care 15:398-402. 2009
    ..In this review, studies published during the past year that increase our understanding of the use of vasoactive drugs in the ICU are discussed...
  95. ncbi Contribution of the 5-HT(1B) receptor to hypoxia-induced pulmonary hypertension: converging evidence using 5-HT(1B)-receptor knockout mice and the 5-HT(1B/1D)-receptor antagonist GR127935
    A Keegan
    Department of Neuroscience and Biomedical Systems, Institute of Biomedical and Life Sciences, University of Glasgow, Scotland
    Circ Res 89:1231-9. 2001
    ..In conclusion, the 5-HT(1B) receptor plays a role in the development of CHPHT. One possible mechanism may be via enhanced 5-HT(1) receptor-mediated contraction of the pulmonary arterial circulation...
  96. ncbi Angiotensin II-induced vascular dysfunction is mediated by the AT1A receptor in mice
    Michael J Ryan
    Department of Internal Medicine, Cardiovascular Center, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City 52242, USA
    Hypertension 43:1074-9. 2004
    ..These data demonstrate that the AT1A receptor is required for Ang II-induced changes in carotid artery function...
  97. pmc The effect of vasopressin on choroidal blood flow, intraocular pressure, and orbital venous pressure in rabbits
    Barbara Bogner
    Department of Ophthalmology and Optometry, SALK Paracelsus Medical University, Salzburg, Austria
    Invest Ophthalmol Vis Sci 52:7134-40. 2011
    ..To investigate the effects of arginine-vasopressin (AVP) on intraocular pressure (IOP), orbital venous pressure (OVP), and choroidal blood flow (ChorBF) regulation in anesthetized rabbits...
  98. ncbi Anti-arrhythmic and vasopressor medications for the treatment of ventricular fibrillation in severe hypothermia: a systematic review of the literature
    Charles R Wira
    Department of Surgery, Section of Emergency Medicine, Yale School of Medicine, New Haven, CT 06510, USA
    Resuscitation 78:21-9. 2008
    ..To determine the rate of return of spontaneous circulation (ROSC) in animal models performing resuscitation from induced ventricular fibrillation (VF) in severe hypothermia (<30 degrees C)...
  99. pmc Growth-dependent changes in the contribution of carbon monoxide to arteriolar function
    Julie Balch Samora
    Department of Physiology and Pharmacology, and Center for Interdisciplinary Research in Cardiovascular Sciences, West Virginia University School of Medicine, Morgantown, W VA, USA
    J Vasc Res 47:23-34. 2010
    ..Endothelium-dependent dilation of skeletal muscle arterioles is mediated by unknown factors in very young rats. We assessed the possible contribution of carbon monoxide (CO) to this dilation and to dilation in older animals...
  100. ncbi Arginine vasopressin vs. terlipressin in the treatment of shock states
    Mervyn Singer
    Bloomsbury Institute of Intensive Care Medicine, University College London, Cruciform Building, Gower Street, London WC1E 6BT, United Kingdom
    Best Pract Res Clin Anaesthesiol 22:359-68. 2008
    ..This review analyses the published literature and makes comparisons, where possible, between vasopressin and terlipressin...
  101. ncbi "Terlipressin in the treatment of septic shock: the earlier the better"?
    Andrea Morelli
    Department of Anaesthesiology and Intensive Care, University of Rome, La Sapienza, Rome, Italy
    Best Pract Res Clin Anaesthesiol 22:317-21. 2008
    ..Randomised, clinical multicenter trials are now needed to investigate whether or not early institution of low-dose continuous terlipressin infusion improves overall outcome of patients suffering from vasodilatory shock states...

Research Grants64

  1. SIGNALING THROUGH RHO GTP/GDP EXCHANGE FACTORS
    Philip B Wedegaertner; Fiscal Year: 2013
    ..The research in this application will provide new knowledge about the functions of RhoGEFs and thus better define how the RhoGEFs can be therapeutically inhibited in disease without affecting their critical normal functions. ..
  2. Endothelial Lipoxygenase Metabolites and Vascular Tone
    WILLIAM BRYSON CAMPBELL; Fiscal Year: 2013
    ..These studies will identify two new mechanisms of action for the endothelium-derived relaxing factor 11,12,15-THETA and provide a new therapeutic approach to enhancing endothelial function. ..
  3. Mitogen-activated Protein Kinases and NF-kB Activation in Vascular Smooth Muscle
    Bingbing Jiang; Fiscal Year: 2010
    ....
  4. Ouabain, Na+ Pumps, and Ca2+ Signaling in Human Arteries
    Laura K Antos; Fiscal Year: 2010
    ..I anticipate that the results will provide the first direct evidence that the underlying key molecular mechanisms in salt-dependent hypertension in rodents function similarly in humans. ..
  5. Oxidant Stress Mechanisms in Preeclampsia
    Scott W Walsh; Fiscal Year: 2013
    ....
  6. Biological Mechanisms of Arterial Stiffening With Age and Estrogen Deficiency
    KERRIE MOREAU; Fiscal Year: 2010
    ..The results should provide new insight into the integrative biological mechanisms by which sex hormone deficiency modulates the age-related reduction in large artery compliance in women as they transition through the menopause. ..
  7. Role of Serotonin in Smypathetic Function
    Karie E Scrogin; Fiscal Year: 2012
    ..will produce less reperfusion injury during resuscitation from hypovolemic shock than clinically used vasoconstrictor agents which tend to constrict arterial vascular beds...
  8. Mechanisms of Intracellular NAMPT-regulated GSNOR in Vessel Wall
    ADAM CARL STRAUB; Fiscal Year: 2013
    ..abstract_text> ..
  9. Mechanisms of Intracellular NAMPT-regulated GSNOR in Vessel Wall
    ADAM CARL STRAUB; Fiscal Year: 2012
    ....
  10. HIV-induced 5-Lipoxygenase: Role in HIV-related Pulmonary Arterial Hypertension
    KRISTI MICHELLE PORTER; Fiscal Year: 2010
    ..These academic faculty members play a critical role in inspiring our youth to become the next generation of teachers, scientists, and doctors. ..
  11. Circulatory system and integrated muscle tissue for drug and tissue toxicity
    George A Truskey; Fiscal Year: 2013
    ..We will examine the response of blood vessels and muscle to an inflammatory stimulus. Metabolic profiling will be performed to simulate different physiological conditions and response to drugs and toxins. ..
  12. TRP Channel-Dependent Regulation of Arterial Tone
    Scott Earley; Fiscal Year: 2013
    ..abstract_text> ..
  13. Renal Vascular Reactivity in Hypertension
    William J Arendshorst; Fiscal Year: 2013
    ..We predict that Ca2+ signaling and vascular responsiveness to vasoconstrictor agents (Ang II, ET-1, TxA2) are attenuated in CD38-deficient vs. WT mice during control and AIH conditions...
  14. Ca2+ Regulation in Chronic Hypoxic Pulmonary Hypertention
    JAMES SK SHAM; Fiscal Year: 2013
    ..The information generated by the proposed experiments may help to develop new treatments for pulmonary hypertension. ..
  15. Vascular control by K+ channel trafficking
    Jonathan H Jaggar; Fiscal Year: 2013
    ..This proposal will provide significant novel information concerning cerebral artery contractility regulation by physiological and pathological mechanisms that control BKCa channel surface expression. ..
  16. Contribution of caveolin to diabetic vascular dysfunction
    Kathryn G Lamping; Fiscal Year: 2013
    ..We will compare the effects of inhibition (siRNA) or overexpression of caveolin-1 using viral transfection on vascular responses to specific serotonin receptor agonists or direct activation of rhoA in non-diabetic and diabetic mice. ..
  17. Mechanisms and Meanings of Impaired Microvascular Responses in Human Sepsis
    Kevin C Doerschug; Fiscal Year: 2013
    ..abstract_text> ..
  18. Vasoregulation by the Cav1.2 channel C-terminus
    Kirk W Evanson; Fiscal Year: 2013
    ..This research will reveal novel mechanisms of vascular contractility regulation by the CaV1.2 channel C-terminus. ..
  19. RGS Protein Function and Regulation
    Kendall J Blumer; Fiscal Year: 2013
    ..Accordingly, this project advances understanding of blood pressure control mechanisms and their dysregulation in hypertension, which may contribute to the identification of new hypertension therapies. ..
  20. Does strial microischemia enhance cochlear aminoglycoside ototoxicity
    Hongzhe Li; Fiscal Year: 2013
    ..The proposed research will determine several risk factors on strial microischemia, and establish a reliable ototoxic mouse model. ..
  21. INHALATIONAL ANESTHETICS AND CORONARY VASOMOTION
    JOHN SILL; Fiscal Year: 1992
    ..An understanding of the relationship anesthetic drugs have to coronary vasomotion is likely to help in the anesthetic management of patients with coronary artery disease undergoing both cardiac and non-cardiac surgery...
  22. CYP 450-mediated CBF Dysregulation and Neurotoxicity in Pediatric Cardiac Arrest
    Mioara D Manole; Fiscal Year: 2013
    ....
  23. CIRRHOSIS AND ITS COMPLICATIONS
    Guadalupe Garcia Tsao; Fiscal Year: 2009
    ..Renewal of the award will allow Dr. Garcia-Tsao to maintain both POR and her mentoring endeavors to their fullest extent so she can continue to make significant contributions in the field of chronic liver disease and its complications. ..
  24. NADPH oxidases-derived ROS downregulate TRPC6 in mesangial cells in diabetes
    Rong Ma; Fiscal Year: 2013
    ..The proposed studies will tackle this important issue by investigating if ROS repress TRPC6 gene transcription through the NF-[unreadable]B mechanism. Thus, this project is of interest to both ROS and TRPC6 fields. ..
  25. Effects of Vasoactive Drugs on Perfusion in Septic Shock
    Patrick Murray; Fiscal Year: 2005
    ..focusing on prevention and management of septic acute renal failure, as a surrogate endpoint to optimize systemic perfusion in hyperdynamic states. ..
  26. ROLE OF SEROTONIN IN PREGNANCY-RELATED HYPERTENSION
    Carl Weiner; Fiscal Year: 1992
    ..receptor status? Question 9: Does the combination of serotonin with the other study agents stimulate prostacyclin release above that which would be expected by simply summing the prostacyclin released in response to the individual agents?..
  27. PO2 MODULATION OF NO AND ET1 IN PULMONARY HYPERTENSION
    Karen Fagan; Fiscal Year: 2002
    ..Improved understanding of these endogenous vasoregulatory substances, their interactions with one another, and the effect of modest hypoxia in vivo are the major goals of this proposal and may lead to new therapeutic options. ..
  28. New roles of Src tyrosine kinases in vascular tone
    LIGIA TORO DE STEFANI; Fiscal Year: 2007
    ..The elucidation of primary steps involved in 5-HT and TXA2 smooth muscle stimulation should help in the design of new therapeutic ways to control cardiovascular disease. [unreadable] [unreadable]..
  29. CALCIUM REGULATION IN ARTERIAL MYOCYTES
    William Goldman; Fiscal Year: 1993
    ..Moreover, these findings may be useful in elucidating pathophysiological processes such as those associated with hypertension...
  30. Clinical Impact of Bradykinin Receptor Polymorphisms
    James Gainer; Fiscal Year: 2005
    ..abstract_text> ..
  31. VASOACTIVE AGENTS IN SPLANCHNIC VISCERA OF PRIMATES
    Kenneth Swan; Fiscal Year: 1980
    Previous attention has been directed to the use of vasoconstrictor agents to control hemorrhagic lesions within the gastrointestinal tract of man. Vasopressin has emerged as the pre-eminent drug of choice...
  32. Genetic Risk Factors for Portopulmonary Hypertension
    Steven Kawut; Fiscal Year: 2005
    ..In addition, this pilot study could suggest targeted preventative or therapeutic modalities, leading to clinical trials for an "orphan" disease routinely excluded from other research programs and trials of therapy. ..
  33. MICROVASCULAR ABNORMALITIES IN SEPSIS
    Steven Hollenberg; Fiscal Year: 2002
    ....
  34. NITRIC OXIDE AND SUPEROXIDE INTERACTIONS IN THE PLACENTA
    Leslie Myatt; Fiscal Year: 2002
    ..5. Expression of mRNA and protein for SOD isoforms, xanthine oxidase and the cytochrome b558 subunit of NADPH oxidase in normal and pathologic placental tissues using RT-PCR and immunohistochemistry. ..
  35. MODERATE ALCOHOL USE--CARDIOVASCULAR RISKS AND BENEFITS
    Thomas Giles; Fiscal Year: 2001
    ..The exacerbation or prevention of EIH will be related to drug effects on the cell-signaling pathway. This research can define the cell-signaling pathway in EIH and provide new and novel approaches to treating EIH. ..
  36. Identifying acute tubular necrosis in cirrhosis patients with renal dysfunction
    Chirag R Parikh; Fiscal Year: 2010
    ..Urinary biomarkers, such as IL-18 and NGAL, which are valuable for identifying acute tubular necrosis in other clinical settings, will be tested in patients with renal failure and cirrhosis in this prospective cohort study. ..
  37. EXPERIMENTAL PATHOLOGY OF THE OPTIC NERVE
    Douglas Anderson; Fiscal Year: 1991
    ....
  38. REGULATION OF PLACENTAL VASCULAR REACTIVITY IN PIH
    Leslie Myatt; Fiscal Year: 1991
    ....
  39. EFFECT OF SEX STEROIDS ON RENAL FUNCTION
    Carmen Hinojosa Laborde; Fiscal Year: 1993
    ..It is hypothesized that male Dahl S rats will respond to volume expansion with an attenuated decrease in renal nerve activity and an attenuated sodium and water excretion as compared to female Dahl S rats...
  40. REGULATION OF VASCULAR ENDOTHELIN PRODUCTION
    A Whorton; Fiscal Year: 1993
    ....
  41. Vascular Function after Exposure of Humans to Hypoxia
    James Weiss; Fiscal Year: 2009
    ..We anticipate that these studies will significantly enhance our understanding of how intermittent hypoxia and obstructive sleep apnea influence vascular tone and function. ..
  42. Regulation of Renal Oxygenation and Blood Pressure
    Pin Lan Li; Fiscal Year: 2006
    ..abstract_text> ..
  43. ALCOHOL AND BLOOD VESSELS; ROLE OF ENDOTHELIAL CELLS
    EDWARD KNYCH; Fiscal Year: 1990
    ..Definition of these mechanisms may lead to new insights concerning the pathological effects of alcohol and their correction...
  44. Tyrosine Kinases in Renal Vasoconstrictor Signaling
    Pamela K Carmines; Fiscal Year: 2010
    ..PHS 398 (Rev. 05/01) Page 2 Principal Investigator/Program Director (Last, first, middle): Carmines, Pamela, K ..
  45. Pathogenesis of Endotoxemia-Induced Acute Renal Failure
    Robert Schrier; Fiscal Year: 2005
    ..The ultimate goal therefore is to understand and prevent the ARF, morbidity and mortality associated with sepsis. ..
  46. Nitric Oxide and Endothelin in Endotoxemic Renal Failure
    Brian Poole; Fiscal Year: 2003
    ..Understanding the early vasoactive events which cause ARF during endotoxemia would be a major medical advance, thereby allowing the development of pathogenetic-based interventions. ..
  47. MICROCIRCULATORY DILATOR MECHANISMS
    Gabor Kaley; Fiscal Year: 1990
    ..will address the existence of this mechanism in the microcirculation, will define which vasodilator and vasoconstrictor agents stimulate its generation and will assess the possible involvement of this factor in autoregulatory ..
  48. MOLECULAR MECHANISMS OF VASOCONSTRICTOR ACTION
    Bradford Berk; Fiscal Year: 1990
    ..The specific aims are consistent with the long-range goals of the applicant which are focused on relating the cell biology of VSMC response to mitogens with the clinical features of atherosclerotic coronary artery disease...
  49. Mechanisms of uterine vascular adaptation in pregnancy
    Natalia Gokina; Fiscal Year: 2006
    ..abstract_text> ..
  50. Viral Infection and Primary Pulmonary Hypertension
    Blossom Damania; Fiscal Year: 2009
    ..Our hypothesis is that KSHV infection of endothelial cells predisposes the endothelial cells to aberrant signaling and proliferation, and this dysfunction is enhanced with HIV co infection. ..
  51. SCOR IN PATHOBIOLOGY OF LUNG DEVELOPMENT
    Merton Bernfield; Fiscal Year: 2001
    ..Our integrated search approach to the critical problem of CLD of infancy will facilitate development of new methods for its prevention and therapy. ..
  52. REGULATION OF PULMONARY VASCULAR TONE
    JOHN MICHAEL; Fiscal Year: 1993
    ..The proposed research will lead to a better understanding of the mechanisms by which vasoconstrictors and vasodilators act alone and in concert to control pulmonary vascular tone...
  53. HYPOXIC REGULATION OF VASOCOSTRICTION
    Peter Kilbridge; Fiscal Year: 1993
    ....
  54. PATHOPHYSIOLOGY OF THE AGING KIDNEY
    Sharon Anderson; Fiscal Year: 2001
    ..The use of a combined physiological, biochemical, immunohistochemical, and molecular biologic approach should gain insight into this clinically important but understudied problem. ..
  55. Endothelial Specific Caveolin-1 Overexpression
    PHILIP BAUER; Fiscal Year: 2003
    ....
  56. RENAL MICROVASCULAR FUNCTION IN AGED RATS
    EDWARD INSCHO; Fiscal Year: 2000
    ..abstract_text> ..
  57. Pulmonary Arterial Hypertension: Avian Model of Complex Vascular Lesion Developme
    ROBERT WIDEMAN; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  58. Microbiology/Immunology of Periodontal Disease in T1DM
    Paul Moore; Fiscal Year: 2002
    ..An integrated multidisciplinary effort provides significant data collection capabilities essential for understanding the complex multifactorial etiology of periodontal disease in Type 1 diabetes. ..
  59. ORAL HEALTH OF OLDER TYPE 1 DIABETIC PATIENTS
    Paul Moore; Fiscal Year: 2003
    ..This overall plan will permit us to understand the etiology of these complications and to define specific subpopulations and risk factors appropriate for future prospective oral health prevention and intervention trials. ..
  60. POTASSIUM CHANNELS AND CEREBRAL HEMODYNAMICS AFTER BRAIN
    William Armstead; Fiscal Year: 2005
    ..These studies may lead to therapies for brain injured children. ..
  61. Vascular cell-to-cell communication during remodeling
    Robin Looft Wilson; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  62. Cannabinoid Receptors and Cerebrovascular Function
    Cecilia Hillard; Fiscal Year: 2006
    ..Increased understanding of the mediators that are released by activated microglia and their targets may provide new therapeutic approaches to CNS diseases with an inflammatory component. ..
  63. Brain Endocannabinoids and Chronic Stress
    Cecilia Hillard; Fiscal Year: 2005
    ..The successful completion of these studies will enhance our understanding of the processes involved in the adaptation of the brain to chronic stress. ..
  64. Arterial 5-HT Transporter Function
    Stephanie Watts; Fiscal Year: 2009
    ..abstract_text> ..